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Role Of Resistant Starch In Improving Gut Health, Adiposity, And Insulin Resistance, Michael J. Keenan, June Zhou, Maren Hegsted, Christine Pelkman, Holiday A. Durham, Diana B. Coulon, Roy J. Martin

Faculty Publications

© 2015 American Society for Nutrition. The realization that low-glycemic index diets were formulated using resistant starch led to more than a decade of research on the health effects of resistant starch. Determination of the metabolizable energy of the resistant starch product allowed for the performance of isocaloric studies. Fermentation of resistant starch in rodent studies results in what appears to be a healthier gut, demonstrated by increased amounts of short-chain fatty acids, an apparent positive change in the microbiota, and increased gene expression for gene products involved in normal healthy proliferation and apoptosis of potential cancer cells. Additionally, consumption …

Role Of Resistant Starch In Improving Gut Health, Adiposity, And Insulin Resistance, Michael J. Keenan, June Zhou, Maren Hegsted, Christine Pelkman, Holiday A. Durham, Diana B. Coulon, Roy J. Martin

Faculty Publications

© 2015 American Society for Nutrition. The realization that low-glycemic index diets were formulated using resistant starch led to more than a decade of research on the health effects of resistant starch. Determination of the metabolizable energy of the resistant starch product allowed for the performance of isocaloric studies. Fermentation of resistant starch in rodent studies results in what appears to be a healthier gut, demonstrated by increased amounts of short-chain fatty acids, an apparent positive change in the microbiota, and increased gene expression for gene products involved in normal healthy proliferation and apoptosis of potential cancer cells. Additionally, consumption …

Prowashonupana Barley Dietary Fibre Reduces Body Fat And Increases Insulin Sensitivity In Caenorhabditis Elegans Model, Chenfei Gao, Michael L. King, Zachary L. Fitzpatrick, Wenqian Wei, Jason F. King, Mingming Wang, Frank L. Greenway, John W. Finley, Jeffrey H. Burton, William D. Johnson, Michael J. Keenan, Frederick M. Enright, Roy J. Martin, Jolene Zheng

Faculty Publications

© 2015 Elsevier Ltd. Prowashonupana barley (PWB) is high in β-glucan with moderate content of resistant starch. PWB reduced intestinal fat deposition (IFD) in wild type Caenorhabditis elegans (C. elegans, N2), and in sir-2.1 or daf-16 null mutants, and sustained a surrogate marker of lifespan, pharyngeal pumping rate (PPR), in N2, sir-2.1, daf-16, or daf-16/daf-2 mutants. Hyperglycaemia (2% glucose) reversed or reduced the PWB effect on IFD in N2 or daf-16/daf-2 mutants with a sustained PPR. mRNA expression of cpt-1, cpt-2, ckr-1, and gcy-8 were dose-dependently reduced in N2 or daf-16 mutants, elevated in daf-16/daf-2 mutants with reduction in cpt-1, …

Comparing Anthropometric Methods To Quantify Relations Between Adiposity And Headache, Vanessa Lee Moynahan

Electronic Theses and Dissertations

Obesity is associated with increased risk for chronic migraine and migraine progression, but associations with episodic migraine (em) and episodic tension-type headache (tth) are unclear. Most studies have relied on bmi as an indicator of adiposity. More accurate anthropometric measures that distinguish adipose tissue from other body tissue are critical to examine adiposity-headache associations, including validated measures of abdominal adiposity and established measurement formulas such as body adiposity index (bai) and body composition equations developed by Peterson et al. (2003) and Garcia et al. (2005). The present study explored adiposity-headache associations by employing established anthropometric measures of adiposity and comparing …

Isothiocyanate-Rich Moringa Oleifera Extract Reduces Weight Gain, Insulin Resistance, And Hepatic Gluconeogenesis In Mice, Patricio Rojas-Silva, Tugba Boyunegmez Tumer, Peter Kuhn, Allison J. Richard, Shawna Wicks, Jacqueline M. Stephens, Zhong Wang, Randy Mynatt, William Cefalu, Ilya Raskin

Faculty Publications

© 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. Scope: Moringa oleifera (moringa) is tropical plant traditionally used as an antidiabetic food. It produces structurally unique and chemically stable moringa isothiocyanates (MICs) that were evaluated for their therapeutic use in vivo. Methods and results: C57BL/6L mice fed very high fat diet (VHFD) supplemented with 5% moringa concentrate (MC, delivering 66 mg/kg/d of MICs) accumulated fat mass, had improved glucose tolerance and insulin signaling, and did not develop fatty liver disease compared to VHFD-fed mice. MC-fed group also had reduced plasma insulin, leptin, resistin, cholesterol, IL-1β, TNFα, and lower hepatic glucose-6-phosphatase …

Weight Management Counseling And Obesity Severity In Children With Special Health Care Needs, Adeola Sonaike

Walden Dissertations and Doctoral Studies

Epidemiologic surveillance indicates an increased susceptibility to obesity among children with special health care needs (SHCN) in comparison to children without. The present study investigated this disparity in weight severity between both groups, with a focus on the provision of obesity management counseling by physicians. This study consisted of a retrospective medical record review that acknowledged the effect of patient-provider interactions on health behaviors and risk perceptions. An independent sample t test compared the incidence of clinician-initiated obesity management counseling received by children with SHCN to that which was received by children without SHCN. This t test revealed a statistically …

The Increasing Weight Of Regulation: Countries Combat The Global Obesity Epidemic, Allyn L. Taylor, Emily Whelan Parento, Laura A. Schmidt

Indiana Law Journal

Obesity is a global epidemic, exacting an enormous human and economic toll. In the absence of a comprehensive global governance strategy, states have increasingly employed a wide array of legal strategies targeting the drivers of obesity. This Article identifies recent global trends in obesity-related legislation and makes the normative case for an updated global governance strategy.

National governments have responded to the epidemic both by strengthening traditional interventions and by developing novel legislative strategies. This response consists of nine important trends: (1) strengthened and tailored tax measures; (2) broadened use of counter-advertising and health campaigns; (3) expanded food labeling; (4) …

Notch Signaling Regulates Adipogenesis And Energy Metabolism, Pengpeng Bi

Open Access Dissertations

Evolutionarily unprepared for high caloric diets and sedentary lifestyles, humans are now unprecedentedly susceptible to obesity and its associated metabolic disorders. Obesity is resulted from malfunction of the overloaded white adipocytes, which are the primary default storage sites of energy surplus. Another two types of adipocytes can also be found in human: beige and brown adipocytes. In opposite to white adipocytes, beige and brown adipocytes ameliorate obesity by burning lipids for thermogenesis. Thus, an increase in beige/brown adipocyte content in adipose tissue, termed browning would raise energy expenditure and reduce adiposity.

Prevalence Of Hypertension And Its Association With Obesity Among Schoolchildren Aged 6-15 Living In Sakarya Province In Turkey, Fati̇h Muhammed Önsüz, Fi̇gen Demi̇r

Turkish Journal of Medical Sciences

Background/aim: Childhood hypertension and its association with obesity are becoming important issues worldwide. The prevalence of hypertension and obesity are growing in both developed and developing countries. This paper aimed to determine the prevalence of hypertension among school-aged children in Sakarya (western part of Turkey) and to determine whether or not obesity is associated with hypertension. Materials and methods: Twelve schools were randomly selected from an area in the center of the Sakarya. A total of 2166 students participated in the study. The students were visited at school, and their weights, heights, and blood pressures were measured. The World Health …

Mental Health In Diabetes Prevention And Intevention Programs In American Indian/Alaska Native Communities, Wynette Whitegoat, Jeremy Vu, Kellie Thompson, Jennifer Gallagher

Buder Center for American Indian Studies Research

American Indian and Alaska Natives youth and adults experience higher rates of type 2 diabetes and mental health problems than the general United States population. Few studies have explored the relationship other than detail the two issues independently. The present review aims to identify programs that seek to prevent/treat type 2 diabetes and mental health disorders in the American Indian and Alaska Native population. Available programs were reviewed for AI/AN adults and youth who suffer with both. As part of the review process, databases were searched for peer reviewed published studies. It was found that very few programs effectively incorporate …

Regulation Of Ghrelin: A Possible Treatment Option For Obesity And Diabetes, Sarah Picciotto

The Science Journal of the Lander College of Arts and Sciences

Obesity is a mounting problem in America today. One major concern about obesity is that it is a risk factor for type 2 diabetes, a disease that impairs insulin sensitivity and secretion. This interferes with blood glucose levels and can cause hyperglycemia, which is when there is too much circulating glucose in the blood. Ghrelin, an amino acid peptide responsible for appetite stimulation and energy balance, plays a direct role in insulin secretion and glucose metabolism. In many experiments, elevated ghrelin levels are associated with decreased insulin secretion from pancreatic islet cells. Although ghrelin concentration is decreased in obese individuals …

Concordance Of Self-Report And Measured Height And Weight Of College Students, Virginia Quick, Carol Byrd-Bredbenner, Suzanne Shoff, Adrienne A. White, Barbara Lohse, Tanya Horacek, Kendra Kattelmann, Beatrice Phillips, Sharon L Hoerr, Geoffrey Greene

Health and Nutritional Sciences Faculty Publications

OBJECTIVE: This study examined associations between college students' self-report and measured height and weight.

METHODS: Participants (N = 1,686) were 77% white, 62% female, aged 18-24 years (mean ± SD, 19.1 ± 1.1 years), and enrolled at 8 US universities. Body mass index (BMI) was calculated for self-report (via online survey); trained researchers measured height and weight and categorized them as normal (18.5 to < 25), overweight (25 to < 30), obese (30 to < 35), and morbidly obese (≥ 35).

RESULTS: Concordance of self-report vs objectively measured BMI groups using chi-square revealed that 93% were accurate, 4% were underestimated, and 2.7% were overestimated. Pearson correlations and adjusted linear regression revealed significant associations between self-report and measured …

Evaluation Of The Move Program On Weight Loss Among Veterans, William Justin Allen

DNP Projects

The most current estimations from the CDC classify more than one third of the American population as obese (2011). This epidemic continues to contribute to a number of chronic diseases across the country including diabetes and heart disease, both associated with high morbidity and mortality (NHLBI, 1998). Billions of dollars are spent annually on obesity and obesity related conditions.

Perhaps this is what led the U.S. Department of Health and Human Services (HHS) to select Nutrition, Physical Activity, and Obesity as a Leading Health Indicator in Healthy People 2020. The updated NHLBI guidelines, based on clinical evidence, offer a blueprint …

Regulation Of Pancreatic Β-Cell Function By The Renin-Angiotensin System In Type 2 Diabetes, Robin C. Shoemaker

Theses and Dissertations--Pharmacology and Nutritional Sciences

Diet-induced obesity promotes type 2 diabetes (T2D). Drugs that inhibit the renin-angiotensin system (RAS) have been demonstrated in clinical trials to decrease the onset of T2D. Previously, we demonstrated that mice made obese from chronic consumption of a high-fat (HF) diet have marked elevations in systemic concentrations of angiotensin II (AngII). Pancreatic islets have been reported to possess components of the renin-angiotensin system (RAS), including angiotensin type 1a receptors (AT1aR), the primary receptor for AngII, and angiotensin converting-enzyme 2 (ACE2), which negatively regulates the RAS by catabolizing AngII to angiotensin-(1-7) (Ang-(1-7)). These two opposing proteins have been implicated in the …

Weight Management Of Women Of Childbearing Age, Marcia Hagen

Walden Dissertations and Doctoral Studies

Black River Memorial Hospital identified obesity as a priority health concern in its rural service area; this concern was in line with the county's needs assessment. It was identified that women of childbearing age affect the lifestyle and health choices of their families and that they are at higher risk for the additional health risks associated with obesity affecting pregnancy and birth. Despite the identification of these risk factors, the factors that affect healthy weight management have not been well understood. Using the life course theory, a qualitative inquiry in the form of a structured interview was developed with local …

An Investigation Into The Effect Of Artificial Sweeteners On The Fertility, Longevity, And Body Fat Content Of Caenorhabditis Elegans, Sofia N. Allison

Theses & ETDs

Global rates of obesity have skyrocketed over the last fifty years to epidemic proportions. Consumption of artificial sweeteners has risen concurrently with the rise in obesity. The efficacy of artificial sweeteners for weight loss is unclear and their widespread usage has recently been called into question. We investigated the effects of three popular artificial sweeteners (aspartame, saccharin, and sucralose) on the fertility, longevity, and body fat content of the nematode Caenorhabditis elegans. Relative to the control, nematodes treated with aspartame or saccharin exhibited depressed fertility and increased body fat, with no effect on pharyngeal pumping rate, a surrogate marker for …

Patchy Progress On Obesity Prevention: Emerging Exemplars, Entrenched Barriers, And New Thinking, Christina A. Roberto, Boyd Swinburn, Corinna Hawkes, Terry T-K Huang, Sergio Costa, Marice Ashe, Lindsey Zwicker, John H. Cawley, Kelly D. Brownell

Publications and Research

Although there have been positive pockets of change, no country has yet turned around its obesity epidemic. Preventing an increase in obesity prevalence will require urgent actions from government as well as a broader spectrum of stakeholders than previously emphasized. In this paper, we review a number of regulatory and non-regulatory actions taken around the world to address obesity and discuss some of the reasons for the patchy progress. In addition, we preview the papers in this Lancet series, which each identify priority actions on key obesity issues and challenge some of the entrenched dichotomies that present obesity and its …

Are New Sodium Targets In The National School Lunch Program Feasible And Are They Necessary?, Yaneve Shemesh

PCOM Biomedical Studies Student Scholarship

In many societies, high salt intake is a continuing issue in adults, and is of growing concern in children due to the prevalence of processed foods. In response, the USDA has set three targets for sodium in meals offered in the National School Lunch Program (NSLP), and the National School Breakfast Program (NSBP). This 8-year goal is meant to decrease overall sodium levels in both meal programs. However, many associated with school nutrition ask if there is significant evidence to show what effect sodium plays on children’s health, and thus determine if these targets are necessary or achievable. In addressing …

A Spatial Analysis Of Obesity And Its Associations With The Built And Natural Environment, Physical Inactivity, And Socioeconomic And Demographic Conditions In The United States Of America, Mustafa Erdem

LSU Doctoral Dissertations

Obesity has strong genetic determinants but the genetic composition of the population does not change rapidly. Thus in this study, the major changes in non-genetic factors such as the development of obesogenic environments and shifting socioeconomic status and lifestyle of individuals are hypothesized to increase the risk of obesity. As the prevalence of obesity continue to increase worldwide with substantial attention in the US, a clearer understanding of how spatial associations between obesity and confounding factors are interrelated is crucial to better tackle the issue of obesity. This study employs the ‘global’ and ‘local’ Exploratory Spatial Data Analysis (ESDA) methods …

Exploring Daily Dietary Behaviour Through Examination Of The Food Choice Process, Ivy Dam

Theses and Dissertations (Comprehensive)

As obesity rates continue to rise, the negative health impacts associated with unhealthy food choice behaviour remain an issue of concern. Observing the connection between food consumption and weight gain alone is likely not sufficient to understanding people’s construction of food choices. More detailed examination of a novel concept, the overall food choice process (FCP), including food thoughts, plans, purchases, and preparation, leading up to food intake/consumption may contribute to an improved understanding of food choice behaviour.

This thesis explored the wider FCP that gives rise to observed food consumption by testing passive video recording technologies, …

Fermentable Non-Digestible Dietary Fiber And Bioactive Compounds Affect Aging And Fat Deposition In Caenorhabditis Elegans, Chenfei Gao

LSU Doctoral Dissertations

Overweight and obesity have been imposing $147 billion a year to the health care system in the United States. Limited medications are available in the market with side effects. Surgical treatments are second-line obesity treatments. Short chain fatty acids (SCFAs) produced from the fermentable resistant starch improves the secretion of satiety hormones peptide YY (PYY) and glucagon-like peptide 1 (GLP-1) from L-endocrine cells of cecum and colon. We hypothesized that consumption of fermentable non-digestible dietary fiber and bioactive compounds will increase insulin sensitivity, reduce body fat, and improve healthspan in Caenorhabditis elegans (C. elegans), and hyperglycemia (2% glucose) that may …

Dietary Strategies To Influence Appetite: Effects Of Oat Beta-Glucan And Thylakoids From Spinach On Satiety And Reward-Induced Eating Behavior, Candida Joan Rebello

LSU Doctoral Dissertations

The objective of these studies was to examine the effects of oat-based cereals and a spinach extract, on eating behavior. The cereals compared included instant oatmeal (IO), old fashioned oatmeal (SO), and a ready to eat cereal (RTEC), each containing the soluble fiber beta-glucan. The spinach extract containing thylakoids, the internal photosynthetic membrane of plants, was compared with a placebo. The first study, a randomized crossover trial compared the effect of IO and SO on subjective ratings of satiety, with the RTEC. Subjects consumed isocaloric 150kcal servings of the cereals in random order. Visual analogue scale ratings evaluating satiety were …

An Examination Of Factors That Contribute To Binge Eating Among Bariatric Patients, Erin Neuman-Boone

Electronic Theses and Dissertations

Binge eating is the most common eating disorder among individuals presenting for bariatric surgery. The majority of patients with pre-surgical binge eating experience a short-term reduction in binge eating symptoms following surgery. However, binge eating symptoms can re-emerge. This quantitative study examined variables related to and predictive of binge eating within the bariatric patient population. Specifically, the purpose of this study was to determine whether daily hassles, uplifts, depression, pre-surgical binge eating, time since surgery, and weight regain were predictors of binge eating within the bariatric patient population. One hundred and twenty-six participants completed either an electronic or paper version …

Diabetes Among Hispanic Immigrants: The Impact Of Age At Migration, Nancy Hahn

Walden Dissertations and Doctoral Studies

Diabetes is a disease that affects the Hispanic population in disproportionate numbers. With larger numbers of immigrants coming to the United States who are of Hispanic origin, the individual risk and health burden of this disease will have a major impact on the quality of life and the health care system. Research into the influence of the timing of changes in lifestyle suggested an association between specific levels of socioecological exposures and certain health conditions. This study examined that possibility. The use of the National Health Interview Survey, 2005-2011, provided adequate data for examining whether age at migration was associated …

Preliminary Nutritional Profile Analysis Of Box Tops 4 Education Food Products, Hannah Griffith

Williams Honors College, Honors Research Projects

The marketing of unhealthy food to children is often cited as a cause of the obesity epidemic.¹ However, most studies that examine this issue evaluated the marketing of food through print or television advertising. This project investigates the marketing of food products to children through incentive based programs, specifically General Mill’s Box Tops 4 Education. This study undertakes a preliminary systematic analysis of Box Tops food items to determine their healthfulness. A subset of all Box Tops food products was selected for review and a basic quantitative content analysis of priority nutrients was performed. Priority nutrients were identified …

Potential Role Of Protein Kinase Cbeta In High Fat Diet-Induced Adipose Dysfunction By Regulating Autophagy Levels, Neil Mehta

Williams Honors College, Honors Research Projects

Obesity is the most common nutritional disorder in the United States and worldwide. Public health efforts and other anti-obesity measures clearly have not controlled the obesity epidemic. There is a great need to understand the pathogenic mechanisms underlying fat accumulation. Research of the past decade supports a prominent role for diet-induced adipose tissue dysfunction in the development and/or progression of obesity and associated insulin resistance. Potential mechanisms for the development of adipose tissue dysfunction include ectopic (visceral) fat accumulation, genetic factors, and alterations in autophagy and inflammatory processes. However, the molecular mechanisms linking dietary fat intake with alterations in adipose …

Vegetable Plate Waste, Lindsey A. Maiani

Williams Honors College, Honors Research Projects

The purpose of this research project was to perform a plate waste and nutrition study comparing Country Pure Foods’ Vegetable Fruit Blend Juices and traditional vegetables. The study was in May of 2014 at Voris and McElbright Community Learning Centers and conducted by students at the University of Akron. When we performed the project we would be looking at students choices in juice versus vegetables and selecting or not selecting. This led us to understand whether the juice or the vegetable was providing more nutrition.

Role Of Diet On Non-Alcoholic Fatty Liver Disease: An Updated Narrative Review, Dimitrios Papandreou, Eleni Andreou

All Works

© 2015 Baishideng Publishing Group Inc. The purpose of this article review is to update what is known about the role of diet on non-alcoholic fatty liver disease (NAFLD). NAFLD is the most common cause of chronic liver disease in the developed world and is considered to be a spectrum, ranging from fatty infiltration of the liver alone (steatosis), which may lead to fatty infiltration with inflammation known as non alcoholic steatohepatitis While the majority of individuals with risk factors like obesity and insulin resistance have steatosis, only few people may develop steatohepatitis. Current treatment relies on weight loss and …

Health-Related Beliefs Among Low-Income African American Women And Their Perceptions About Obesity, Cenora Kimberly Akhidenor

Walden Dissertations and Doctoral Studies

The aim of this study was to explore the health-related beliefs and perceptions of low-income African American women regarding obesity. Phenomenology served as the conceptual framework for this study. African American women, especially those in low-income brackets, have been shown to weigh more than women of other racial/ethnic groups. The consequences of these high rates are increased risks of developing chronic health disorders, such as type II diabetes and cardiovascular disease. The study sample consisted of 7 low-income obese African American women, ranging in age from 20 to 62, who resided in the Pacific Northwest. Recruitment for participation occurred via …

Obesity Surveillance In Childhood, Jessica Garcia

Walden Dissertations and Doctoral Studies

Current practice behaviors for obesity management have remained refractory. Research has shown that lack of time and poor training/skills by primary care providers has led to poor or absent obesity counseling in practice. The purpose of this intervention was to facilitate obesity counseling in a pediatric office by using an evidence-based model called the 5As model of behavioral change. Lewin's change theory was the framework for this project to help clinicians transition their practice to include the 5As model in practice. The project consisted of a 30-minute power point presentation that included 2 case samples demonstrating how the 5As would …