Digital Commons Network^™

Guggulsterone Activates Adipocyte Beiging Through Direct Effects On 3t3-L1 Adipocytes And Indirect Effects Mediated Through Raw264.7 Macrophages., Colette N Miller, Janaiya S Samuels, Yusra Azhar, Ashish Parmar, Rangaiah Shashidharamurthy, Srujana Rayalam

PCOM Scholarly Works

Background: Plant-derived phytochemicals have been of emerging interest as anti-obesity compounds due to their apparent effects on promoting reduced lipid accumulation in adipocytes. Despite such promising evidence, little is known about the potential mechanisms behind their anti-obesity effects. The aim of this study is to establish potential anti-obesity effects of the phytochemical guggulsterone (GS). Methods: Mature 3T3-L1 adipocytes were treated with GS, derived from the guggul plant native in northern India, to investigate its effects on mitochondrial biogenesis and adipocyte "beiging." Further, to explore the relationship between macrophages and adipocytes, 3T3-L1s were treated with conditioned media from GS-treated RAW264.7 macrophages. …

Disruption Of The Hippocampal And Hypothalamic Blood-Brain Barrier In A Diet-Induced Obese Model Of Type Ii Diabetes: Prevention And Treatment By The Mitochondrial Carbonic Anhydrase Inhibitor, Topiramate, Therese S. Salameh, William G. Mortell, Aric F. Logsdon, D. Allan Butterfield, William A. Banks

Chemistry Faculty Publications

Background: Type II diabetes is a vascular risk factor for cognitive impairment and increased risk of dementia. Disruption of the blood–retinal barrier (BRB) and blood–brain barrier (BBB) are hallmarks of subsequent retinal edema and central nervous system dysfunction. However, the mechanisms by which diet or metabolic syndrome induces dysfunction are not understood. A proposed mechanism is an increase in reactive oxygen species (ROS) and oxidative stress. Inhibition of mitochondrial carbonic anhydrase (mCA) decreases ROS and oxidative stress. In this study, topiramate, a mCA inhibitor, was examined for its ability to protect the BRB and BBB in diet-induced obese type II …

Correlation Of Body Mass Index Percentile And Craniofacial Morphology: A Retrospective, Cross-Sectional Study, Adam G. Danze

Student Theses, Dissertations and Capstones

Introduction: Obesity rates are rising exponentially in many countries around the world, particularly in the United States. This epidemic is affecting people of all ages, and little to no progress has been made it slow it down. Lack of physical activity and increased consumption of energy rich foods and caloric intake have been recognized as contributing factors for the concerning increase in the prevalence of obesity in child and adult populations. The high prevalence of obesity is believed to be a complex interplay of genetic, environmental, socioeconomic, cultural, and psychological factors. Childhood obesity is occurring at progressively younger ages, leading …

Endogenous Antioxidant Overexpression As An Adjuvant To Diet Or Exercise Intervention As Therapy To Counteract Obesity And Beneficially Shift The Gut Microbiome, Deborah Lynn Amos

Theses, Dissertations and Capstones

Oxidative stress plays a key role in metabolic syndrome which includes obesity and cardiometabolic diseases. It is implicated that oxygen-derived free radicals generated during the mitochondrial electron transport chain alter the function of specific biological components, thus activating obesogenic pathways such as glucose and lipid signaling. Research on this topic is of vital importance as obesity is a high-risk factor in the development and progression of severe, debilitating, life-threatening maladies such as cardiometabolic diseases, chronic inflammatory pathologies, and cancer. Furthermore, there is no universal effective therapy to combat the rising rates of obesity with over 1.9 billion (39%) adults classified …

Bariatric Surgery Outcomes In Appalachia Influenced By Surgery Type, Diabetes, And Depression, Makenzie L. Barr, Lawrence E. Tabone, Stephanie J. Cox, Cassie Brode, Nova Szoka, I. Mark Olfert, Laura Davisson, Melissa D. Olfert

Faculty & Staff Scholarship

Background

Most effective treatment for morbid obesity and its comorbidities is bariatric surgery. However, research is limited on weight loss and associated outcomes among patients in Appalachia. The objective of this study was to examine demographic and comorbidity influence on surgical outcomes of this population including age, sex, race, state of residence, education, marital status, body mass index (BMI kg/m2), excess body weight (EBW), percent excess weight loss (%EWL), blood pressure, diagnosed depression, diagnosed type 2 diabetes (T2D), Beck Depression Inventory-II (BDI-II), and laboratory values (i.e., hemoglobin A1c).

Methods

A retrospective electronic medical record (EMR) data extraction was performed on …

Cooking Frequency Associated With Dietary Quality In Icook-4h Youth Participants At Baseline, Amber D. Ford, Sarah E. Colby, Marissa Mcelrone, Lisa Franzen-Castle, Melissa D. Olfert

Faculty & Staff Scholarship

Background: Increased intakes of ready-made and fast foods paralleled with decreased homemade food consumption have been associated with increased rates of obesity. Researchers have shown associations between cooking self-efficacy (SE) and cooking frequency (CF) with dietary quality and weight status. Some cooking interventions have shown positive associations with dietary outcomes, such as increased fruit and vegetable intake and decreased fast food consumption. There is still much unknown about SE and CF, especially among youth. Objective: Determine baseline SE and CF and the associations with dietary quality and body mass index (BMI) of youth enrolled in iCook 4H. Methods: Youth (n=228, …

Cholinergic Control Of Inflammation, Metabolic Dysfunction, And Cognitive Impairment In Obesity-Associated Disorders: Mechanisms And Novel Therapeutic Opportunities, E. H. Chang, S. S. Chavan, V. A. Pavlovh

Journal Articles

No abstract provided.

Are Health Problems In Adulthood Linked To Our Experiences In The Womb? An Epigenetic Approach, Simone Tendler

The Science Journal of the Lander College of Arts and Sciences

The origins of adult disease have been a prime topic for research, as deciphering causes can lead to strategies for preventions and cures. There has been recent intrigue focused on the environment in the womb. Records from England and Wales in 1911 show that those who suffered from cardiovascular disease were geographically correlated with regions high in infant mortality in the past, seventy years before the study. When looking into the cause of the neonatal death rates, low birth weight, poor maternal health, and high maternal death rates during childbirth were clearly associated. Barker inferred that there is much happening …

Naktide Targeted To Adipocytes Ameliorates Western Diet Induced Obesity, Rebecca D. Pratt

Theses, Dissertations and Capstones

Obesity has become a worldwide epidemic and is a major risk factor for metabolic syndrome. It is believed that cellular oxidant stress plays a key role in both the development and maintenance of obesity as well as its associated comorbidities such as diabetes, cardiovascular disease, and nonalcoholic steatohepatitis (NASH). We have previously reported that systemic administration of pNaKtide, which targets the Na/K-ATPase oxidant amplification loop was able to decrease oxidative stress and adiposity in mice fed a high fat and fructose supplemented western diet (WD). As adipocytes are believed to play an active role in the development of obesity and …

Experiences Of Providers In Caring For The Obese Hispanic Population, Emma Gladson

Regis University Student Publications (comprehensive collection)

The national obesity rate continues to rise along with numerous correlating health disparities in Colorado. According to Andolf and Fisichella (2018), obesity currently affects 78.6 million people in the United States. Obesity is without a doubt a major health concern. Obesity in children and adolescents is a growing concern in the United States, where one fifth of the entire population from age two to nineteen in 2011-2014 was obese (Obesity, Diet and Mortality Trends, 2016). The objective of this project was to examine experiences of healthcare providers caring for the obese Hispanic population. Determining the experiences in providing care for …

Study Protocol Of A Pragmatic Randomized Controlled Trial Incorporated Into The Group Lifestyle Balance™ Program: The Nutrigenomics, Overweight/Obesity And Weight Management Trial (The Now Trial), Justine Horne, Jason A. Gilliland, Colleen O’Connor,, Jamie A. Seabrook, Peter Hannaberg, Janet Madill

Human Environments Analysis Lab (HEAL)

Background

The nutrigenomics, overweight/obesity and weight management trial (NOW Trial) is a pragmatic randomized controlled trial of community-dwelling adults recruited from the Group Lifestyle Balance™ (GLB™) Program. The GLB™ Program (formerly referred to as the Diabetes Prevention Program) is an evidence-based, intensive weight management program, which was offered to overweight/obese patients (BMI ≥ 25.0 kg/m2) in a rural Ontario community.

Methods

Patients enrolled in the GLB™ Program were invited to participate in this study. GLB™ groups were randomized 1:1 to receive either the standard GLB™ program + population-based lifestyle advice for weight management, or a modified GLB™ program + personalized, …

Nutrition Education For The Underserved Youth Within The Greater Twin Cities Area Through The Insports Foundation, Paige D. Deters, Allison Kaper, Maura Romanshek

All Electronic Theses and Dissertations

It has been examined that poor access to nutritious foods and limited opportunities for physical activity is prevalent among children from underserved families. These deficiencies contribute to increasing childhood obesity rates and emphasize the need for early interventions. Establishing nutritional literacy and understanding the importance of an active lifestyle in early childhood can lead to long-term health benefits and reduction in chronic disease later in life (HHS & USDA, 2015; Tsai et al., 2011; Wang et al., 2011). The InSports Foundation serves as a comprehensive non-profit organization that addresses many of these issues by providing children from underserved families with …

Exploring Sensemaking Of The Healthy Hunger-Free Kids Act Of 2010, Taylor Mary Barczyk

Wayne State University Dissertations

The Healthy Hunger-Free Kids Act of 2010 was reauthorized to create school environments that provide nutrient-dense meals to students who are living in poverty. The free and reduced-price lunch program helps 19% of students who are living in poverty in America (Kids Count Data Center, 2017). These students arrive at school hungry and often times are more concerned about their hunger than the content they need to learn. In order to assist them in learning, the school lunch program has been established. With the policy reauthorization of Public Law 111-296, students have been able to receive nourishment in the school …

The Effect Of Nursing Interventions And Health Promotion On Childhood Obesity: A Literature Review, Grace N. Mageloff

Honors Undergraduate Theses

Childhood obesity is a growing epidemic in the United States that has short-term and long-term health consequences for the children affected. Nurses are patient advocates and are responsible for speaking up for the patient; in the pediatric population, a nurse must act as an advocate on behalf of the child. The purpose of this literature review is to look at different barriers to nursing interventions in regard to childhood obesity. A literature review was done by using different databases, with 11 articles having similar themes and interventions used. The main themes from the literature review were parental willingness and involvement …

Leptin Level Variance In Adults With And Without Cancer, Vilisa Chatman-Terry

Walden Dissertations and Doctoral Studies

Abstract

In 2018, health statistics revealed that, despite the many preventive measures established,

cancer was the second leading cause of death in the United States and the leading cause

of death in 22 states, exceeded only by heart disease. With obesity/leptin levels reaching

pandemic levels worldwide, and cancer having a well-known association with obesity,

both chronic diseases represent a large proportion of public health challenges. Guided by

the social ecological model, the purpose of this cross-sectional, quantitative study was to

examine if a significant difference exists in leptin levels among adults with different

types of obesity-associated and common cancers and …

Differences In Running Mechanics And Tibial Plateau Dimensions Between Overweight/Obese And Healthy Weight Children, Claire Sylvestre

Electronic Theses and Dissertations

INTRODUCTION: Overweight and obese (OW/OB) children display increased knee joint loading during running, which may lead to excessive frontal plane motion and moments at the knee joints. The relationship between tibial plateau dimensions and knee vertical loading may explain the loading related injuries OW/OB children experience.
PURPOSE: Compare knee mechanics during running and tibial plateau dimensions between healthy weight (HW) and OW/OB children.
METHODS: Ten HW children and ten OW/OB children aged 9-12 participated in the study. Kinematic and kinetic data were captured as participants ran across a force platform at 3.5m/s. Tibial plateau area and density were collected by …

Relationship Of Weight-Related Eating Behaviors And Weight-Loss Of Participants In A Proprietary Weight-Loss Program, Megan Tschakert

Electronic Theses and Dissertations

The aim of this study is to evaluate weight-related eating behaviors of participants with clinically significant weight loss (CSWL) in a proprietary weight loss program. A crosssectional sample of participants (n=1,454) enrolled in a proprietary weight-loss program that includes meal replacements and health coaching were queried for weight-related eating behaviors (using Weight Related Eating Questionnaire) of routine restraint (RR), compensatory restraint (CR), susceptibility to external cues (SEC), and emotional eating (EE) in relation to CSWL (defined as having achieved a weight loss greater than 10% of starting weight). Participants were dichotomized into those with CSWL (n=973) and with no CSWL …

Prevalence Of Chronic Disease, Associated Factors, And Health Related Quality Of Life Among Wesleyan Clergy, Angi May Mook

All-Inclusive List of Electronic Theses and Dissertations

Clergy believe they have been called to be healthy and role models of good health. However, epidemiological evidence supports that clergy are currently exhibiting higher rates of chronic diseases and associated factors such as obesity, diabetes, and hypertension compared to the general population. Prior studies of clergys health are limited because the few available studies are denomination specific, limiting generalizability to the other denominations who have differing theology and beliefs. The Wesleyan denomination has not been formally studied. The gap in literature, therefore, creates a need for baseline information specific to the Wesleyan clergy. This cross-sectional study assessed the prevalence …

Adapting An Elementary School Nutrition Context Assessment For High School Settings And Students, Deborah H. John, Beret Halverson, Tia H. Ho

Urban Studies and Planning Faculty Publications and Presentations

The school nutrition context is comprised of supportive environmental features, programs, policies, and social relationships that shape students’ healthy dietary choices and patterns. When engaging students as change agents, advocates, and partners in making healthy nutrition choices easier, environmental assessment tools developed for adults may be too complex or inappropriately tailored for youth. Adolescents need practical, user-tailored tools that reliably measure the food and beverage environments they encounter in school to inform youth-led changes to the school nutrition context. To meet this need, an evidence-based school environmental assessment was adapted for use in high schools by students as evaluators. Cooperative …

Natural Environment Associations With Mental Health And Obesity Status, Adam Edwin London

Walden Dissertations and Doctoral Studies

Mental health and obesity were ranked among the health priorities of the 2014 and 2017 Community Health Needs Assessments in Kent County, Michigan. Exposure to nature is correlated to improved health outcomes across a variety of morbidities including poor mental health and obesity. This cross-sectional study set within the frameworks of attention restoration theory, environmental health, and pathways to health benefits from nature assessed county survey data including self-reported nature exposures/interactions separated into 3 domain areas: access to nature, attitudes about nature, and physical activity in nature or in nature-based activities. Binary logistic regression analyses of the 653 respondents found …

Physical Activity And Dietary Interventions For Adolescent African Americans In Mississippi, Tanga Deson Hart Robinson

Walden Dissertations and Doctoral Studies

African American (AA) adolescents have higher rates of obesity than many other ethnic groups, which increases their risk for obesity-related diseases. Culturally sensitive obesity preventive interventions have been unsuccessful, resulting in a steady increase of obesity among AA adolescents. AA adolescents in the southern region of the United States are at a higher risk for obesity and physical inactivity; knowledge and understanding of causative factors remains limited. To identify the impact of programs, a systematic review of the literature focused on structured physical activity and/or dietary education interventions in Mississippi. The ecological framework was used to guide this study. The …

Effects Of Maternal Obesity On Preterm Birth And Birthweight, La Tosha Headley

Walden Dissertations and Doctoral Studies

Obesity is one of the major risk factors for neonate low birthweight among reproductive women. The purpose of this quantitative study was to examine the association between 3 categories of obese status (moderate, severe, and very severe) and low neonate birthweight and preterm birth among women ages 18 to 39 years at all socioeconomic levels. Secondary data were obtained from 141,859 women ages 18-39 years living in the United States who had participated in the 2012-2015 Pregnancy Risk Assessment Monitoring System. Social-ecological theory was used to guide the study, and binary logistic regression was used for the analyses adjusting for …

The Influence Of Food Choices, Eating Habits, And Body Image Of African American Mothers On Childhood Obesity, Debrua Perniece Coleman

Walden Dissertations and Doctoral Studies

The food decisions, dietary patterns, physical activity, and weight-related convictions of African American mothers are affected by their self-perceptions and views of body weight. The gap in the literature regarding the impact of these perceptions on children's food choices, eating habits, and body image is significant. Using the health belief model as the theoretical foundation and a cross-sectional survey as the research design, this study assessed the potential relationship between mothers' and children's eating habits and whether mothers' perceptions of their children's body image were reliable indicators of childhood obesity. Eighty-six mothers provided demographic information and completed the Child Feeding …

Nurses' Perceptions Of Patient Encounters During Bariatric Weight Loss Surgery Education, Traci Edwynne Cullins-Clark

Walden Dissertations and Doctoral Studies

Many researchers have suggested positive patient-health provider relationships can positively impact patient outcomes. A few focused explicitly on bariatric weight loss surgery (BWLS) professional-patient interactions. This study is significant because BWLS is a recommended tool to combat obesity. The purpose of this study was to analyze the perceptions of BWLS education nurses regarding their patient encounters. This mixed methods research study used an online survey combining quantitative Likert scale questions and open-ended qualitative questions, with social cognitive theory as the theoretical foundation. These explored viewpoints relate to their patient relations expressed by a health professional. Health professional beliefs incorporated into …

Cultivating Cultural Competence To Address Childhood Obesity In Ethnic Minority Youth, Tia Knight-Forbes

Walden Dissertations and Doctoral Studies

Obesity is an increasingly prevalent health issue, especially among children who live in high poverty, low income, and low education areas that lack needed resources and health care to promote quality of life. African American youth have a higher rate of obesity than other populations. The purpose of this project was to address an identified gap in practice by improving health care professionals' ability to provide culturally competent care to African American youth. An educational intervention framed by the Purnell model for cultural competence was developed to address the question, Will cultural competency staff education improve knowledge to prevent and …

Weight Management Toolkit For Patients On Methadone, Bolaji Olugboja

Walden Dissertations and Doctoral Studies

Methadone is a mu-opioid agonist used in the treatment of patients with an opioid use disorder in an outpatient addiction treatment clinic. A recognized knowledge gap exists among nurses managing overweight and obese patients in an outpatient methadone treatment center in the northeastern United States. The goal of this project was to develop a weight management toolkit to assist nurses in the identification, evaluation, and management of overweight and obese patients receiving methadone treatment at the center. The evidence-based weight management toolkit incorporated practice guidelines from the American Heart Association, American Association of Clinical Endocrinologists, America College of Cardiology, and …

Sugar-Sweetened Beverages: A Survey To Assess Adults Knowledge, Attitudes, And Consumption Patterns Of Sugar-Sweetened Beverages, Jeff Schafer

All Graduate Theses, Dissertations, and Other Capstone Projects

Sugar-sweetened beverages (SSBs) have a direct impact on the general health of the country when looking at the rising obesity levels (CDC, 2017a). The USDA’s dietary guidelines suggest that the daily intake of added sugar should be limited to 6 teaspoons for women and 9 teaspoons for men (Hughes, 2017). However, the average American consumes 20 teaspoons of sugar daily (Hughes, 2017). These extra calories are converted into fat and stored in the body. Data collected throughout the years indicates a rise in the number of Americans living with a weight above healthy recommendations, which is termed, obese. Obesity is …

Right Size Me : Policy Responses To The Obesity Eidemic And Behavioral Change, Wenhui Feng

Legacy Theses & Dissertations (2009 - 2024)

Obesity is a critical health and social concern. Almost 40% of American adults are obese, creating more than $300 billion dollars in annual medical costs. While obesity is a public concern that has been on the policy agenda for some time, obesity policies have proven difficult to formulate, adopt and implement in practice. In this dissertation, I explore three obesity-related policies – adoption of obesity prevention policies by local health department, calorie labeling on restaurant menus and food assistance benefits – and find the importance of ideological and political considerations for obesity policies at different stages in the policy process …

Assessment Of Asymmetric Dimethyl Arginine, Cardiac Troponin I, Thyroxine, Cholesterol, And Triglyceride Levels In Obese Dogs And Dogs With Normal Body Condition, Hüseyi̇n Ci̇han, Merve Tural

Turkish Journal of Veterinary & Animal Sciences

The aim of this study was to assess serum asymmetric dimethyl arginine (ADMA), cardiac troponin I (cTnI), thyroxine (T4), cholesterol and triglyceride (TG) levels in dogs with normal body condition and obese dogs. A total of 40 dogs (n = 40) were included in the study and dogs were divided into two groups; 20 dogs with normal body condition and 20 obese dogs. The dogs were grouped according to the five-point body-condition scoring (BCS) system. Serum ADMA, cTnI, T4, cholesterol, and TG levels were measured in addition to routine biochemical parameters. Serum ADMA, cTnI, TG, and cholesterol levels were statistically …

Eat Smart, Play Hard The Oyate Way: Impact Of A Culturally Tailored Nutrition And Physical Activity Curriculum On Elementary Youth, Abbey Hillestad

Electronic Theses and Dissertations

Objective: To assess changes in nutrition and physical activity (PA) knowledge and behavior in elementary-age participants from school districts with high American Indian enrollment after completion of a culturally tailored education curriculum.
Design: Pre-post intervention study assessing knowledge and behavior using quantitative methods. Participants: A total of 248 participants (Kindergarten through 5th grade, n=248) throughout 13 elementary classrooms in tribal communities participated in Eat Smart. Play Hard.: The Oyate Way. Intervention(s): Baseline and post intervention data from a culturally tailored nutrition and PA knowledge and behavior curriculum.
Main Outcome Measure(s): Dependent variables were nutrition and PA knowledge, and nutrition and …