Digital Commons Network^™

Genetic Architecture Of Human Obesity Traits In The Rhesus Macaque, Michael J. Raboin, John Letaw, Asia D. Mitchell, David Toffey, Jessica Mckelvey, Charles T. Roberts Jr, Joanne E. Curran, Amanda Vinson

School of Medicine Publications

Objective: Whereas the metabolic consequences of obesity have been studied extensively in the rhesus macaque, corollary genetic studies of obesity are nonexistent. This study assessed genetic contributions to spontaneous adiposity in this species.

Methods: Phenotypic variation by age class and sex for BMI, waist to height ratio, waist to thigh ratio, and waist circumference was assessed in 583 macaques. Total and sex-specific heritability for all traits was estimated, including waist to thigh ratio adjusted for BMI, as well as genotypic and phenotypic correlations. In addition, functional genetic variation at BDNF, FTO, LEP, LEPR, MC4R, PCSK1, POMC, and SIM1 was assessed …

Investigation Of The Role For Methyl-Cpg Binding Protein 2 Variant Mbd2_V2 In Cancer Stem Cells And Obesity-Associated Cancers, Emily A. Teslow

Wayne State University Dissertations

Obesity is a risk factor for both TNBC and PCa, and pro-inflammatory features associated with obesity, including upregulated production of ROS, promote CSCs. Previously published work from the Bollig-Fischer laboratory established that TNBC CSCs could be inhibited by neutralizing ROS in culture with H2O2 targeted antioxidants. In this report, antioxidant treatment resulted in the downregulation of mRNA splicing variant MBD2_v2. MBD2_v2 was highly expressed in CSCs versus bulk TNBC cells and supported self-renewal in vitro. As obesity is coupled with increased ROS, we hypothesized that obesity could drive CSCs via MBD2_v2 expression. The work presented in this thesis addressed this …

Prevalence Of Chronic Disease, Associated Factors, And Health Related Quality Of Life Among Wesleyan Clergy, Angi May Mook

All-Inclusive List of Electronic Theses and Dissertations

Clergy believe they have been called to be healthy and role models of good health. However, epidemiological evidence supports that clergy are currently exhibiting higher rates of chronic diseases and associated factors such as obesity, diabetes, and hypertension compared to the general population. Prior studies of clergys health are limited because the few available studies are denomination specific, limiting generalizability to the other denominations who have differing theology and beliefs. The Wesleyan denomination has not been formally studied. The gap in literature, therefore, creates a need for baseline information specific to the Wesleyan clergy. This cross-sectional study assessed the prevalence …

The Body Mass Index Of San Francisco Cold Water Swimmers - Comparisons To U.S. National And Local Populations, And Pool Swimmers, Brendan T. Crow, Ellicott C. Matthay, Stephen P. Schatz, Mark D. Debeliso, Thomas J. Nuckton

International Journal of Exercise Science

International Journal of Exercise Science 10(8): 1250-1262, 2017. To determine if cold-water swimmers have substantial differences in BMI, which might have a protective effect against heat loss during swims in cold water without wetsuits, and to determine if obesity is more or less prevalent in cold-water swimmers, we compared the body mass index (BMI) values of 103 recreational open-water swimmers (mean age 54.3 ±10.8 years) to data from various population groups. Swimmers swam consistently throughout the winter months, in the San Francisco Bay (water temperature range: 9.6° C [49.3 ° F] to 12.6° C [54.7 ° F]), without wetsuits. After …

Trace Elements And Human Obesity: An Overview, Shamshad Karatela, Neil I. Ward

Manipal Journal of Nursing and Health Sciences

The human body requires certain amount of trace elements to function properly (especially those that are classified as essential to health). Most elements are co-factors in the molecular mechanisms within the body but when in excess can also cause toxicity. Concentrations of some elements in excess (above optimum) or deficient amount can progress to some types of metabolic abnormalities which could lead to obesity. Obesity is a multifactorial condition with multiple pathways including environmental, dietary, and genetic. All these factors, including elemental abnormalities can disrupt the molecular mechanisms. Whilst there is evidence that obesity causes several elemental deficiencies, there is …

The Importance Of Having Two X Chromosomes, Jenny Link, Arthur P. Arnold, Karen Reue, Mansoureh Eghbali, Eric Vilain, Xuqi Chen, Negar Ghahramani, Yuichiro Itoh, Jingyuan Li, Tuck Ngun, Shayna M. Williams-Burris

Biology

Historically, it was thought that the number of X chromosomes plays little role in causing sex differences in traits. Recently, selected mouse models have been used increasingly to compare mice with the same type of gonad but with one versus two copies of the X chromosome. Study of these models demonstrates that mice with one X chromosome can be strikingly different from those with two X chromosomes, when the differences are not attributable to confounding group differences in gonadal hormones. The number of X chromosomes affects adiposity and metabolic disease, cardiovascular ischaemia/reperfusion injury and behaviour. The effects of X chromosome …

Urolithin A, C And D, But Not Iso-Urolithin A And Urolithin B, Attenuate Triglyceride Accumulation In Human Cultures Of Adipocytes And Hepatocytes, Inhae Kang, Yongeun Kim, Francisco A. Tomás-Barberán, Juan Carlos Espín, Soonkyu Chung

Department of Nutrition and Health Sciences: Faculty Publications

Scope: Urolithins (Uro) are ellagic acid (EA)-derived metabolites produced by gut microbes. There is a growing interest in the biological activities of Uro. Our aim was to evaluate the impacts of Uro on regulating triglyceride (TG) accumulation using cultures of primary human adipocytes and hepatoma Huh7 cells.

Methods and Results: UroA, B, C, D, and iso-UroA, were used to determine the effect of Uro on adipogenesis and lipogenesis. Individual Uro (30 M) were added to human adipogenic stem cells (hASCs) during differentiation. UroA, C and D, but not iso-UroA and UroB, significantly inhibited new fat cell formation by decreasing TG …

Healthy Weight Maintenance: Narrative Analysis Of Weight Cycling In The Formerly Obese, Cheri Renee Lewis

Walden Dissertations and Doctoral Studies

Medical and economic costs for obesity are estimated at $147 billion per year, yet less than 1/3 of overweight individuals successfully maintain weight loss. The literature is replete with descriptions of the problem and research on treatments, yet demonstrations of effective loss and maintenance are lacking. Missing is an understanding of the experiences of individuals who successfully maintained healthy weight loss, which could provide insights regarding effective psycho-social interventions. The purpose of this qualitative narrative study was to explore key events and experiences in the lives of former weight cyclers. The primary phenomena of interest included weight cycling and sustained …

Maternal Obesity And Incidence Of Depression, Caroline A. Habjan

Renée Crown University Honors Thesis Projects - All

Obesity is a national epidemic in the United States, which both directly and indirectly affects the social productivity of individuals, the American macro economy and individuals’ personal health and well being. Depression often interferes with an individual’s ability to work, sleep, study, eat, and enjoy life. A maternal state of both obesity and depression may cause serious adverse medical conditions in the mother’s child. Taking steps to treat depression and obesity are critical in the construct of modern medicine. This project yields results that have the potential to make treatment options better tailored, more efficient, effective and economically-sound for the …

The Healthy, Hunger-Free Kids Act And High School Obesity, Derek Grills

Walden Dissertations and Doctoral Studies

United States high school student obesity rates have doubled in the past 30 years to 13%, threatening the health of millions of adolescents. To mitigate the epidemic, Congress passed the Healthy, Hunger-Free Kids Act (HHFKA) in 2010, which mandated significant changes to school nutrition and physical education. From a public policy perspective, the HHFKA changed school nutrition and exercise policy to affect obesity rates by changing intake and energy expenditure at school, though no study using national-level data examined this relationship. As such, the purpose of the study was to examine whether HHFKA policy compliance had a statistically significant effect …

Phosphoinositide 3-Kinase (Pi3k) P11alpha Catalytic Subunit In Adipose Tissue Regulates Systemic Metabolism, Victoria Leigh Boughton

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

Adipose tissue is a highly insulin responsive organ that contributes to metabolic regulation. Insulin resistance in the adipose tissue affects systemic lipid and glucose homeostasis. Phosphoinositide 3-kinase (PI3K) mediates downstream insulin signaling in adipose tissue, but its physiological role in vivo remains unclear. Using Cre recombinase driven by the aP2 promoter, we created mice that lack the class 1A PI3K catalytic subunit p110alpha or p110beta specifically in the white and brown adipose tissue. The loss of p11alpha, not p110beta, resulted in increased adiposity, glucose intolerance and liver steatosis. Mice lacking p110alpha in adipose tissue exhibited a decrease in energy expenditure …

Primary Prevention Of Childhood Obesity, Registered Nurses' Association Of Ontario

General Submissions: Community and Population-based Materials

The purpose of this Guideline is to provide nurses across all practice settings with evidence-based practice, education, system, organization and policy recommendations for the primary prevention of obesity in infants, preschool, and elementary-school-aged children.

Sarcopenia, Obesity, And Natural Killer Cell Immune Senescence In Aging: Altered Cytokine Levels As A Common Mechanism, Charles T. Lutz, Lebris S. Quinn

Pathology and Laboratory Medicine Faculty Publications

Human aging is characterized by both physical and physiological frailty. A key feature of frailty, sarcopenia is the age-associated decline in skeletal muscle mass, strength, and endurance that characterize even the healthy elderly. Increases in adiposity, particularly in visceral adipose tissue, are almost universal in aging individuals and can contribute to sarcopenia and insulin resistance by increasing levels of inflammatory cytokines known collectively as adipokines. Aging also is associated with declines in adaptive and innate immunity, known as immune senescence, which are risk factors for cancer and all-cause mortality. The cytokine interleukin-15 (IL-15) is highly expressed in skeletal muscle tissue …

An Examination Of Family Nutrition Programs Implemented By Mississippi State University Extension Service In Jackson Public Schools, Gabrielle La'dale Bryant

Theses and Dissertations

The Supplemental Nutrition Assistance Program-Education (SNAP-Ed) includes programs and educational curricula that promote healthy behaviors for people receiving nutrition assistance benefits, or eligible for benefits. This study investigated whether information given to children through SNAP-Ed nutrition education programs implemented in schools was taken home to educate parents. After programs were delivered to students by Mississippi State University Extension Service Nutrition Educators, parents (N=302, response rate=43.1%) of elementary students in eight public schools in Jackson, Mississippi, reported changes they made in their households. These changes included eating more fruits and vegetables or trying different fruits and vegetables, and being more physically …

Time Course Of Vascular Function Changes Following An Acute Maximal Exercise Bout In Obese And Normal Weight Males, R. Lee Franco

Theses and Dissertations

One of the earliest sub-clinical stages associated with atherosclerosis is endothelial dysfunction (ED), which has been shown to predict future cardiovascular events. Chronic exercise is thought to improve endothelium-dependent vasodilation; however, few studies have evaluated the effects of acute exercise on vascular function (VF). Moreover, studies evaluating ED following an exercise training program lack a standardized time frame in which to measure VF. Although most studies require subjects to abstain from exercise for 24 hours prior to any VF measure, no study to date has assessed VF longer than 24 hours after the cessation of exercise. Additionally, no studies have …

Correlation Between Serum Leptin Levels, Body Mass Index And Obesity In Omanis, Masoud Y. Al Maskari, Adel A. Alnaqdy

Sultan Qaboos University Medical Journal

Objective: To ascertain the relationship between serum leptin levels and related variables (weight, Body Mass Index (BMI) and fat percentage) in a group of Omani obese and non-obese healthy subjects. Methods: Leptin levels were assessed in serum samples from 35 obese Omanis and 20 non-obese healthy subjects. Results: There was a significant difference (p< 0.001) in serum leptin between the obese group (34.78 + 13.96 ng/ml) and the control non-obese subjects (10.6 ± 4.2 ng/ml). Leptin levels were higher in females compared to males. There was a significantly positive correlation between leptin levels in obese subjects with weight (p=0.002), body fat percentage (p=0.0001) and BMI (p=0.001). Conclusions: We concluded that serum leptin levels are higher in the Omani obese group and correlate positively with body fatness and obesity.

Oxpat/Pat-1 Is A Ppar-Induced Lipid Droplet Protein That Promotes Fatty Acid Utilization, Nathan E. Wolins, Benjamin K. Quaynor, James R. Skinner, Anatoly Tzekov, Michelle A. Croce, Matthew C. Gropler, Vijayalakshmi Varma, Aiwei Yao-Borengasser, Neda Rasouli, Philip A. Kern, Brian N. Finck, Perry E. Bickel

Clinical and Translational Science Faculty Publications

Lipid droplet proteins of the PAT (perilipin, adipophilin, and TIP47) family regulate cellular neutral lipid stores. We have studied a new member of this family, PAT-1, and found that it is expressed in highly oxidative tissues. We refer to this protein as "OXPAT." Physiologic lipid loading of mouse liver by fasting enriches OXPAT in the lipid droplet tissue fraction. OXPAT resides on lipid droplets with the PAT protein adipophilin in primary cardiomyocytes. Ectopic expression of OXPAT promotes fatty acid-induced triacylglycerol accumulation, long-chain fatty acid oxidation, and mRNAs associated with oxidative metabolism. Consistent with these observations, OXPAT is induced in mouse …

Civil Rights And The "Twinkie" Tax: The 900-Pound Gorilla In The War On Obesity, Sayward Byrd

Louisiana Law Review

No abstract provided.

The Role Of Uncoupling Protein 3 In Human Physiology, W. Timothy Garvey

MUSC Faculty Journal Articles

Obesity is simply understood as an imbalance between energy intake and expenditure in favor of weight accretion. However, the human biological interface between food consumption and energy dissipation results in broad individual differences in eating behavior, physical activity, and efficiency of fuel storage and metabolism. In particular, the basal metabolic rate, which accounts for the greatest portion of overall energy expenditure, can vary almost twofold among individuals. Classically, three major biochemical systems are believed to contribute to basal thermogenesis: futile cycles, Na+/K+ATPase activity, and mitochondrial proton leak. The latter is the most important quantitative contributor and can explain up to …