Digital Commons Network^™

Defining Current Gaps In Quality Measures For Cancer Immunotherapy: Consensus Report From The Society For Immunotherapy Of Cancer (Sitc) 2019 Quality Summit, Sara Pai, David Blaisdell, Rachel Brodie, Robert G. Carlson, Heidi Finnes, Michele Galioto, Roxanne E. Jensen, Tom Valuck, Antonia R. Sepulveda, Howard L. Kaufman

Population and Public Health Sciences Faculty Publications

Background Quality measures are important because they can help improve and standardize the delivery of cancer care among healthcare providers and across tumor types. In an environment characterized by a rapidly shifting immunotherapeutic landscape and lack of associated long-term outcome data, defining quality measures for cancer immunotherapy is a high priority yet fraught with many challenges. Methods Thus, the Society for Immunotherapy of Cancer convened a multistakeholder expert panel to, first, identify the current gaps in measures of quality cancer care delivery as it relates to immunotherapy and to, second, advance priority concepts surrounding quality measures that could be developed …

Online Availability Of Fish Antibiotics And Documented Intent For Self-Medication, Weiwei Zhang, Austin Williams, Nicole Griffith, Jessica Gaskins, P Brandon Bookstaver

Faculty Publications

Self-medication and antibiotic utilization without healthcare oversight may lead to delayed appropriate treatment, transmission of communicable infections, untoward adverse events, and contribute to antimicrobial resistance. Previous data suggest people obtain over-the-counter (OTC) animal antibiotics for their personal use. This study examined the availability of OTC fish antibiotics online and the documented intent for self-medication. The authors conducted a web-based cross-sectional study using Google search engine to identify vendor websites selling fish antibiotics in the United States. Vendor websites were included if product information, consumer reviews, and comments were publicly available. Nine fish antibiotics were chosen due to their possibility of …

Healthcare Practitioners’ Views Of Social Media As An Educational Resource, Adam G. Pizzuti, Karan H. Patel, Erin K. Mccreary, Emily Heil, Christopher M. Bland, Eric Chinaeke, Bryan L. Love, P Brandon Bookstaver

Faculty Publications

Social media is increasingly utilized as a resource in healthcare. We sought to identify perceptions of using social media as an educational tool among healthcare practitioners. An electronic survey was distributed to healthcare administrators, nurses, nurse practitioners, pharmacists, physicians, and physician assistants f hospital systems and affiliated health science schools in Georgia, Maryland, South Carolina, and Wisconsin. Survey questions evaluated respondents' use and views of social media for educational purposes and workplace accessibility using a Likert scale (1 = strongly disagree, 5 = strongly agree). Nurses (75%), pharmacists (11%), and administrators (7%) were the most frequent respondents. Facebook® (27%), Pinterest® …

Mapping Language Function With Task-Based Vs. Resting-State Functional Mri, Ki Yun Park, John J. Lee, Donna Dierker, Laura M. Marple, Carl D. Hacker, Jarod L. Roland, Daniel S. Marcus, Mikhail Milchenko, Michelle M. Miller-Thomas, Tammie L. Benzinger, Joshua S. Shimony, Abraham Z. Snyder, Eric C. Leuthardt

Open Access Publications

BACKGROUND: Use of functional MRI (fMRI) in pre-surgical planning is a non-invasive method for pre-operative functional mapping for patients with brain tumors, especially tumors located near eloquent cortex. Currently, this practice predominantly involves task-based fMRI (T-fMRI). Resting state fMRI (RS-fMRI) offers an alternative with several methodological advantages. Here, we compare group-level analyses of RS-fMRI vs. T-fMRI as methods for language localization.

PURPOSE: To contrast RS-fMRI vs. T-fMRI as techniques for localization of language function.

METHODS: We analyzed data obtained in 35 patients who had both T-fMRI and RS-fMRI scans during the course of pre-surgical evaluation. The RS-fMRI data were analyzed …

Motile Onchocerca Volvulus Microfilariae In The Anterior Chamber Of The Eye, Michael E Gyasi, Augustine R Hong, Gary J Weil

Open Access Publications

No abstract provided.

The Impact Of A Wireless Audio System On Communication In Robotic-Assisted Laparoscopic Surgery: A Prospective Controlled Trial, Ziv Tsafrir, Kirsten Janosek-Albright, Joelle Aoun, Mireya Diaz-Insua, Abd-El-Rahman Abd-El-Barr, Lauren Schiff, Shobhana Talukdar, Mani Menon, Adnan R. Munkarah, Evan Theoharis, David Eisenstein

Obstetrics, Gynecology and Women's Health Services Articles

BACKGROUND: Robotic surgery presents a challenge to effective teamwork and communication in the operating theatre (OR). Our objective was to evaluate the effect of using a wireless audio headset device on communication, efficiency and patient outcome in robotic surgery.

METHODS AND FINDINGS: A prospective controlled trial of team members participating in gynecologic and urologic robotic procedures between January and March 2015. In the first phase, all surgeries were performed without headsets (control), followed by the intervention phase where all team members used the wireless headsets. Noise levels were measured during both phases. After each case, all team members evaluated the …

Integrating A Multidisciplinary Pain Team And Chiropractic Care In A Community Health Center: An Observational Study Of Managing Chronic Spinal Pain, Christopher Prater, Melissa Tepe, Patrick Battaglia

Open Access Publications

BACKGROUND: Chronic spinal pain is one of the most common diseases in the United States. Underserved patients are most affected, and disproportionately may use opioid medications as they lack access to other therapies. It is therefore important to develop systems to treat spinal pain within the primary medical home.

METHODS: We designed a prospective observational pilot study at a community health center to measure the effectiveness of two interventions among an underserved population: a multidisciplinary pain team and chiropractic care. Study outcomes were pain and functional disability measured by the Pain Disability Questionnaire (PDQ), and reduction of opioid dose at …

Dopamine D3 Receptor: A Neglected Participant In Parkinson Disease Pathogenesis And Treatment?, Pengfei Yang, Joel S Perlmutter, Tammie L S Benzinger, John C Morris, Jinbin Xu

Open Access Publications

Parkinson disease (PD) is a neurodegenerative disorder characterized by motor and non-motor symptoms which relentlessly and progressively lead to substantial disability and economic burden. Pathologically, these symptoms follow the loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc) associated with abnormal α-synuclein (α-Syn) deposition as cytoplasmic inclusions called Lewy bodies in pigmented brainstem nuclei, and in dystrophic neurons in striatal and cortical regions (Lewy neurites). Pharmacotherapy for PD focuses on improving quality of life and primarily targets dopaminergic pathways. Dopamine acts through two families of receptors, dopamine D1-like and dopamine D2-like; dopamine D3 receptors (D3R) belong to dopamine …

Jesus And The Mosaic Law: Agapic Love As The Foundation And Objective Of Law, Robert F. Cochran ,Jr.

Touro Law Review

No abstract provided.

Identification And Evaluation Of Epidemic Prediction And Forecasting Reporting Guidelines: A Systematic Review And A Call For Action, Simon Pollett, Michael Johansson, Matthew Biggerstaff, Lindsay C. Morton, Sara L. Bazaco, David Brett-Major, Anna M. Stewart-Ibarra, Julie A. Pavlin, Suzanne Mate, Rachel Sippy, Laurie J. Hartman, Nicholas G. Reich, Irina Maljkovic Berry, Jean-Paul Chretien, Benjamin M. Althouse, Diane Myer, Cecile Viboud, Caitlin Rivers

Journal Articles: Epidemiology

INTRODUCTION: High quality epidemic forecasting and prediction are critical to support response to local, regional and global infectious disease threats. Other fields of biomedical research use consensus reporting guidelines to ensure standardization and quality of research practice among researchers, and to provide a framework for end-users to interpret the validity of study results. The purpose of this study was to determine whether guidelines exist specifically for epidemic forecast and prediction publications.

METHODS: We undertook a formal systematic review to identify and evaluate any published infectious disease epidemic forecasting and prediction reporting guidelines. This review leveraged a team of 18 investigators …

Echo Care: Providing Multidisciplinary Specialty Expertise To Support The Care Of Complex Patients, Miriam Komaromy, Judy Bartlett, Andrea Zurawski, Sarah R. Gonzales-Van Horn, Summers G. Kalishman, Venice Ceballos, Xi Sun, Martin Jurado, Sanjeev Arora

Project ECHO Bibliography

BACKGROUND: Programs for high-need, high-cost (HNHC) patients can improve care and reduce costs. However, it may be challenging to implement these programs in rural and underserved areas, in part due to limited access to specialty consultation.

AIM: Evaluate the feasibility of using the Extension for Community Health Outcomes (ECHO) model to provide specialist input to outpatient intensivist teams (OITs) dedicated to caring for HNHC patients.

SETTING: Weekly group videoconferencing sessions that connect multidisciplinary specialists with OITs.

PARTICIPANTS: Six OITs across New Mexico, typically consisting of a nurse practitioner or physician assistant, a registered nurse, a counselor or social worker, and …

The Relationship Between Chronic Health Conditions And Cognitive Deficits In Children, Adolescents, And Young Adults With Down Syndrome: A Systematic Review, Kellen C Gandy, Heidi A Castillo, Lara Ouellette, Jonathan Castillo, Philip J Lupo, Lisa M Jacola, Karen R Rabin, Kimberly P Raghubar, Maria M Gramatges

Library Staff Publications

BACKGROUND: Individuals with Down syndrome are predisposed to a number of chronic health conditions, but the relationship between these conditions and cognitive ability is not clear. The primary objective of this systematic review is to assess this relationship by evaluating studies that measure cognitive performance in the context of Down syndrome-associated chronic health conditions.

METHODS: A systematic review was conducted in accordance with the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) guidelines. Studies included in this review (1) included children, adolescent, and young adult participants with Down syndrome and one or more co-occurring health conditions; (2) were quantitative; …

Mitigating A Covid-19 Outbreak Among Major League Baseball Players - United States, 2020, Meghan T. Murray, Margaret A. Riggs, David M. Engelthaler, Caroline Johnson, Sharon Watkins, Allison Longenberger, David Brett-Major, John Lowe, M. Jana Broadhurst, Chandresh N. Ladva, Julie M. Villanueva, Adam Macneil, Shoukat Qari, Hannah L. Kirking, Michael Cherry, Ali S. Khan

Journal Articles: Epidemiology

Mass gatherings have been implicated in higher rates of transmission of SARS-CoV-2, the virus that causes coronavirus disease 2019 (COVID-19), and many sporting events have been restricted or canceled to limit disease spread (1). Based on current CDC COVID-19 mitigation recommendations related to events and gatherings (2), Major League Baseball (MLB) developed new health and safety protocols before the July 24 start of the 2020 season. In addition, MLB made the decision that games would be played without spectators. Before a three-game series between teams A and B, the Philadelphia Department of Public Health was notified of a team A …

The Covid-19 Response In Nebraska: How Students Answered The Call, Sabrine Chengane, Anlan Cheney, Sierra Garth, Sharon J. Medcalf

Journal Articles: Epidemiology

The Student Response Team at the University of Nebraska Medical Center answered the statewide call to assist local health departments during the coronavirus disease 2019 (COVID-19) pandemic. As a voluntary student-led effort, the SRT assisted health departments to conduct contact tracing, monitor social media, and educate the public. Their experience demonstrates how students can increase the public health surge capacity of local health departments while gaining applied experience during public health emergencies. This call-to-action commentary proposes that SRTs should be formed, trained, and deployed through academic institutions across the nation and the globe, during and beyond the current pandemic.

Glioma-Derived Exosomes Drive The Differentiation Of Neural Stem Cells To Astrocytes, Krishna D. Sharma, Danielle Schaal, Rajshekhar A. Kore, Rabab N. Hamzah, Sahitya Chetan Pandanaboina, Abdallah Hayar, Robert J. Griffin, Malathi Srivatsan, Nathan S. Reyna, Jennifer Yanhua Xie

Arkansas Biosciences Institute

Exosomes appear to be effective inter-cellular communicators delivering several types of molecules, such as proteins and RNAs, suggesting that they could influence neural stem cell (NSC) differentiation. Our RNA sequencing studies demonstrated that the RNAs related to cell proliferation and astrocyte differentiation were upregulated in human mesenchymal stem cells (hMSC) when co-cultured with exosomes obtained from the culture medium of human glioma cells (U87). Metallothionein 3 and elastin genes, which are related to cell proliferation, increased 10 and 7.2 fold, respectively. Expression of genes for astrocyte differentiation, such as tumor growth factor alpha, induced protein 3 of the NOTCH1 family, …

Humans Of St. Norbert: Danielle Geerling, Danielle Geerling

Humans of St. Norbert

Based on the phenomenon "Humans of New York," Humans of St. Norbert mirrors the photoblog, featuring photos and interviews of people on campus.

Humans Of St. Norbert: Will Starke ’21, Will Starke

Humans of St. Norbert

Based on the phenomenon "Humans of New York," Humans of St. Norbert mirrors the photoblog, featuring photos and interviews of people on campus.

Humans Of St. Norbert: Reid Riggle, Reid Riggle

Humans of St. Norbert

Based on the phenomenon "Humans of New York," Humans of St. Norbert mirrors the photoblog, featuring photos and interviews of people on campus.

Humans Of St. Norbert: Randi Groff ’21, Randi Groff

Humans of St. Norbert

Based on the phenomenon "Humans of New York," Humans of St. Norbert mirrors the photoblog, featuring photos and interviews of people on campus.

Humans Of St. Norbert: Tyler Clark Mba ’20, Tyler Clark Mba

Humans of St. Norbert

Based on the phenomenon "Humans of New York," Humans of St. Norbert mirrors the photoblog, featuring photos and interviews of people on campus.

Humans Of St. Norbert: Ralph Hombsch ’24, Ralph Hombsch

Humans of St. Norbert

Based on the phenomenon "Humans of New York," Humans of St. Norbert mirrors the photoblog, featuring photos and interviews of people on campus.

Humans Of St. Norbert: Philip Klickman, Philip Klickman

Humans of St. Norbert

Based on the phenomenon "Humans of New York," Humans of St. Norbert mirrors the photoblog, featuring photos and interviews of people on campus.

Humans Of St. Norbert: Nick Meisner, Nick Meisner

Humans of St. Norbert

Based on the phenomenon "Humans of New York," Humans of St. Norbert mirrors the photoblog, featuring photos and interviews of people on campus.

Humans Of St. Norbert: Neale Tracy ’21, Neale Tracy

Humans of St. Norbert

Based on the phenomenon "Humans of New York," Humans of St. Norbert mirrors the photoblog, featuring photos and interviews of people on campus.

Humans Of St. Norbert: Molly Kubica ’23, Molly Kubica

Humans of St. Norbert

Based on the phenomenon "Humans of New York," Humans of St. Norbert mirrors the photoblog, featuring photos and interviews of people on campus.

Humans Of St. Norbert: Marquise Weatherall ’22, Marquise Weatherall

Humans of St. Norbert

Based on the phenomenon "Humans of New York," Humans of St. Norbert mirrors the photoblog, featuring photos and interviews of people on campus.

Humans Of St. Norbert: Madeline Pamperin ’20, Madeline Pamperin

Humans of St. Norbert

Based on the phenomenon "Humans of New York," Humans of St. Norbert mirrors the photoblog, featuring photos and interviews of people on campus.

Humans Of St. Norbert: Madison Earing ’22, Madison Earing

Humans of St. Norbert

Based on the phenomenon "Humans of New York," Humans of St. Norbert mirrors the photoblog, featuring photos and interviews of people on campus.

Humans Of St. Norbert: Lisa Gray, Lisa Gray

Humans of St. Norbert

Based on the phenomenon "Humans of New York," Humans of St. Norbert mirrors the photoblog, featuring photos and interviews of people on campus.

Humans Of St. Norbert: Kodee Zarnke ’21, Kodee Zarnke

Humans of St. Norbert

Based on the phenomenon "Humans of New York," Humans of St. Norbert mirrors the photoblog, featuring photos and interviews of people on campus.