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Flood Fatalities In Eastern Kentucky And The Public Health Legacy Of Mountaintop Removal Coal Mining, W. Jay Christian, Beverly May, Jeffery E. Levy May 2023

Flood Fatalities In Eastern Kentucky And The Public Health Legacy Of Mountaintop Removal Coal Mining, W. Jay Christian, Beverly May, Jeffery E. Levy

UK CARES Faculty Publications

Heavy rains at night caused severe flooding in eastern Kentucky on 28 July 2022, resulting in 39 deaths. Using publicly available information, we assembled a database of these fatalities, including demographic characteristics and location of death. We perturbed fatality locations and plotted them on a topographical map highlighting mountaintop removal mining with valley fill sites, where mountaintops were excavated to mine thin seams of coal. This map reveals many flood fatalities occurred along rivers or streams near such sites. Previous research suggests that surface mining has contributed to the majority of land cover change in this region, and this has …


The Relationship Between Upper Body Muscular Power And Objectively Measured Physical Function In Healthy Older Adults, Jordan Stroope May 2023

The Relationship Between Upper Body Muscular Power And Objectively Measured Physical Function In Healthy Older Adults, Jordan Stroope

Graduate Theses and Dissertations

The population of older adults is growing rapidly worldwide. There are significant challenges associated with an aging population, many of which are related to declining physical function. Muscular power has previously been postulated as an important physical characteristic for preserving physical function, however, much of the research has measured lower body muscular power against functional outcomes. The importance of upper body muscular power (UBMP) for physical function outcomes is less clear, thus, this study sought to examine that relationship. Forty-two older adults between the ages of 50 – 70 (avg = 60.5 years  5.7) were recruited for the current …


Exploring Inmate Health In Prisons: Health Issues, Interventions, And Suggestions To Improve Care, Jenna Healy Apr 2023

Exploring Inmate Health In Prisons: Health Issues, Interventions, And Suggestions To Improve Care, Jenna Healy

Honors Program Theses and Projects

The United States has the highest number of prisoners per capita at 639 people per 100,0008. There has been a fivefold increase in the number of inmates in the United States prison systems since 197044, and this may be a major contributor to the corrections healthcare system having trouble keeping up with this growth compared to the general population of the United States. According to the World Health Organization, the United States has documented higher mortality rates than many other developed countries. Rates of conditions such as cardiovascular disease have decreased everywhere, but much less in the United States. In …


From Big Farm To Big Pharma: A Differential Equations Model Of Antibiotic-Resistant Salmonella In Industrial Poultry Populations, Rilyn Mckallip Apr 2023

From Big Farm To Big Pharma: A Differential Equations Model Of Antibiotic-Resistant Salmonella In Industrial Poultry Populations, Rilyn Mckallip

Honors Theses

Antibiotics are used in poultry production as prophylaxis, curative treatment, and growth promotion. The first use is as prophylaxis, or prevention of common bacterial diseases. The crowded conditions in concentrated animal feeding operations necessitate management of infectious disease to ensure overall animal health and the profitability of such operations. In these farms, between 20,000 and 125,000 birds are raised in shed-like enclosures [3], with an average of less than one square foot of space per chicken [34]. Antibiotics are currently used in chicken farms to manage and prevent common bacterial diseases such as respiratory and digestive tract infections, as well …


Results Of The 2022 Immunization Status Survey Of 24-Month-Old Children In Tennessee, Tennessee. Department Of Health. Mar 2023

Results Of The 2022 Immunization Status Survey Of 24-Month-Old Children In Tennessee, Tennessee. Department Of Health.

Immunization Rates

No abstract provided.


Ancient Pathogens Provide A Window Into Health And Well-Being, Cecil M. Lewis Jr., Mercy Y. Akinyi, Sharon Dewitte, Anne C. Stone Jan 2023

Ancient Pathogens Provide A Window Into Health And Well-Being, Cecil M. Lewis Jr., Mercy Y. Akinyi, Sharon Dewitte, Anne C. Stone

Faculty Publications

This perspective draws on the record of ancient pathogen genomes and microbiomes illuminating patterns of infectious disease over the course of the Holocene in order to address the following question. How did major changes in living circumstances involving the transition to and intensification of farming alter pathogens and their distributions? Answers to this question via ancient DNA research provide a rapidly expanding picture of pathogen evolution and in concert with archaeological and historical data, give a temporal and behavioral context for heath in the past that is relevant for challenges facing the world today, including the rise of novel pathogens.


The Nih-Moderna Vaccine: Public Science, Private Profit, And Lessons For The Future, Christopher J. Morten Jan 2023

The Nih-Moderna Vaccine: Public Science, Private Profit, And Lessons For The Future, Christopher J. Morten

Faculty Scholarship

This commentary highlights the scientific history of the NIH-Moderna COVID-19 vaccine and corroborates Sarpatwari’s theme of private capture of value created by the public. The commentary also identifies missteps by the Trump and Biden Administrations and offers policy recommendations: better contracts with and incentives for pharmaceutical manufacturers and a not-for-profit “public option” for pharmaceutical development.


Summary Of Aboriginal And Torres Strait Islander Health Status - Selected Topics 2022, Australian Indigenous Healthinfonet Jan 2023

Summary Of Aboriginal And Torres Strait Islander Health Status - Selected Topics 2022, Australian Indigenous Healthinfonet

Research outputs 2022 to 2026

The Summary of Aboriginal and Torres Strait Islander health status - selected topics 2022 (Summary) is a useful resource for those working or studying in the Aboriginal and Torres Strait Islander health sector. It provides general information regarding the health status of Aboriginal and Torres Strait Islander people covering the following topics:

  • the Aboriginal and Torres Strait Islander population
  • determinants of health
  • information pertaining to births and pregnancy, deaths and hospitalisation
  • burden of disease
  • chronic conditions including cardiovascular disease, cancer, diabetes, kidney and respiratory health
  • social and emotional wellbeing (including mental health)
  • selected sexually transmissible infections
  • environmental health
  • tobacco and …


Overview Of Aboriginal And Torres Strait Islander Health Status 2022, Australian Indigenous Healthinfonet Jan 2023

Overview Of Aboriginal And Torres Strait Islander Health Status 2022, Australian Indigenous Healthinfonet

Research outputs 2022 to 2026

The main purpose of the Overview of Aboriginal and Torres Strait Islander health status (Overview) is to provide a comprehensive summary of the most recent indicators of the health and current health status of Australia’s Aboriginal and Torres Strait Islander people. The Overview has been prepared by HealthInfoNet staff as part of our contribution to supporting those who work in the Aboriginal and Torres Strait Islander health sector. The Overview is a key indicator of the HealthInfoNet’s commitment to authentic and engaged knowledge development and exchange. The initial sections of this Overview provide information about the context of Aboriginal and …


Natural Selection Of Immune And Metabolic Genes Associated With Health In Two Lowland Bolivian Populations, Amanda J. Lea, Angela Garcia, Jesusa Arevalo, Julien F. Ayroles, Kenneth Buetow, Steve W. Cole, Daniel Eid Rodriguez, Maguin Gutierrez, Heather M. Highland, Paul L. Hooper, Anne Justice, Thomas Kraft, Kari E. North, Jonathan Stieglitz, Hillard Kaplan, Benjamin C. Trumble, Michael Gurven Dec 2022

Natural Selection Of Immune And Metabolic Genes Associated With Health In Two Lowland Bolivian Populations, Amanda J. Lea, Angela Garcia, Jesusa Arevalo, Julien F. Ayroles, Kenneth Buetow, Steve W. Cole, Daniel Eid Rodriguez, Maguin Gutierrez, Heather M. Highland, Paul L. Hooper, Anne Justice, Thomas Kraft, Kari E. North, Jonathan Stieglitz, Hillard Kaplan, Benjamin C. Trumble, Michael Gurven

ESI Publications

A growing body of work has addressed human adaptations to diverse environments using genomic data, but few studies have connected putatively selected alleles to phenotypes, much less among underrepresented populations such as Amerindians. Studies of natural selection and genotype–phenotype relationships in underrepresented populations hold potential to uncover previously undescribed loci underlying evolutionarily and biomedically relevant traits. Here, we worked with the Tsimane and the Moseten, two Amerindian populations inhabiting the Bolivian lowlands. We focused most intensively on the Tsimane, because long-term anthropological work with this group has shown that they have a high burden of both macro and microparasites, as …


Engagement Journalism In Action: Supporting New Yorkers With Long Covid, Sarah Luft Dec 2022

Engagement Journalism In Action: Supporting New Yorkers With Long Covid, Sarah Luft

Capstones

What do asthma and long COVID have in common? 1 in 13 U.S. adults are living with them. This report is a recap of my efforts to address the information needs of New Yorkers with long COVID as a student in CUNY's Craig Newmark Graduate School of Journalism engagement program. For my final project, I partnered with THE CITY, a nonprofit news outlet serving New Yorkers, to expand the MISSING THEM project. The report details the what, why, and how of my engagement reporting process, including a community engagement framework, a service journalism series, and lessons to carry forward. You …


Sacred Sex Or Purely Prostitution? Women’S Health During The Covid-19 Pandemic In Roro Kembang Sore Tomb, Tulungagung, East Java, Indonesia, Diah Ariani Arimbi, Gesang Manggala Nugraha Putra, Nurul Fitri Hapsari Dec 2022

Sacred Sex Or Purely Prostitution? Women’S Health During The Covid-19 Pandemic In Roro Kembang Sore Tomb, Tulungagung, East Java, Indonesia, Diah Ariani Arimbi, Gesang Manggala Nugraha Putra, Nurul Fitri Hapsari

Journal of International Women's Studies

The practice of seeking pesugihan (a Javanese term for fortune or wealth, usually achieved by visiting a sacred burial ground of a historic prominent figure or mythical beings) through free-sex rituals is one of the factors that has increased the prevalence of HIV and AIDS, especially in the Tulungagung region of East Java, Indonesia. Often under the guise of tradition, this practice is maintained without proper supervision from governing agencies. To assess this problem, this study focuses on mapping the origin and distribution of free-sex myths in the pesugihan ritual, especially at the burial site of Nyi Roro Kembang Sore, …


Investigating The Relationships Between Concentrated Disadvantage, Place Connectivity, And Covid-19 Fatality In The United States Over Time, Fengrui Jing, Zhenlong Liu, Shan Qiao, Jiajia Zhang Ph.D., Bankole Olatosi Ph.D., Xiaoming Li Ph.D. Dec 2022

Investigating The Relationships Between Concentrated Disadvantage, Place Connectivity, And Covid-19 Fatality In The United States Over Time, Fengrui Jing, Zhenlong Liu, Shan Qiao, Jiajia Zhang Ph.D., Bankole Olatosi Ph.D., Xiaoming Li Ph.D.

Faculty Publications

Background Concentrated disadvantaged areas have been disproportionately affected by COVID-19 outbreak in the United States (US). Meanwhile, highly connected areas may contribute to higher human movement, leading to higher COVID-19 cases and deaths. This study examined the associations between concentrated disadvantage, place connectivity, and COVID-19 fatality in the US over time. Methods Concentrated disadvantage was assessed based on the spatial concentration of residents with low socioeconomic status. Place connectivity was defined as the normalized number of shared Twitter users between the county and all other counties in the contiguous US in a year (Y = 2019). COVID-19 fatality was measured …


Jail Health And Early Release Practices, Brandon L. Garrett, Deniz Ariturk, Jessica Carda-Auten, David L. Rosen Dec 2022

Jail Health And Early Release Practices, Brandon L. Garrett, Deniz Ariturk, Jessica Carda-Auten, David L. Rosen

William & Mary Bill of Rights Journal

Local jails in the United States incarcerate millions of people each year. The COVID-19 pandemic made jail health a pressing public health concern nationally, where releasing individuals from jails occurred across the country in order to prevent pandemic spread. But releases also faced substantial resistance and exposed long-standing challenges in delivering adequate healthcare in jail settings. People in jail have substantially higher levels of medical need than individuals in the general population, with large numbers having serious mental illnesses and substance use disorders. Further, overcrowded conditions and poor healthcare standards and delivery make jails harmful to those already-vulnerable people. What …


Probiotic Incorporation Into Yogurt And Various Novel Yogurt-Based Products, Douglas W. Olson, Kayanush J. Aryana Dec 2022

Probiotic Incorporation Into Yogurt And Various Novel Yogurt-Based Products, Douglas W. Olson, Kayanush J. Aryana

Faculty Publications

Probiotics are commonly added to yogurt to provide many health benefits for the consumer. A description is provided for some commonly used probiotics in yogurt. A GRAS (generally recognized as safe) list of probiotic bacteria that can be added to yogurt or similar types of products is provided. Additionally, prebiotics, synbiotics (combination of prebiotics and probiotics), postbiotics, paraprobiotics, and psychobiotics can be added to yogurt. Probiotic yogurt can come in various forms in addition to spoonable yogurt, and yogurt can be used as an ingredient in other food products. Many useful functional ingredients can be applied to probiotic yogurt. The …


Poly Under Pandemic: A Pilot Survey Examining Cal Poly Slo’S Student Body During The Covid-19 Pandemic, Brett Vollrath Oct 2022

Poly Under Pandemic: A Pilot Survey Examining Cal Poly Slo’S Student Body During The Covid-19 Pandemic, Brett Vollrath

Journalism

The following is a survey of Cal Poly SLO students and alumni who had attended the university while major pandemic restrictions were in place. The paper is based around a pilot survey and data set.

The introduction provides background on the problem and how this survey was prepared.

The literature review details research conducted during the pandemic, which was used to guide the survey's focus questions.

The survey section details the questions asked of respondents. Respondents were first asked demographic questions to establish reference points. They were then asked questions on different aspects of student life, such as mental health, …


The Intersections Of Sex And Inequality In A Mixed Status Industrial London Sample, Anna Green Aug 2022

The Intersections Of Sex And Inequality In A Mixed Status Industrial London Sample, Anna Green

Boise State University Theses and Dissertations

Saint Pancras Burial Ground and its inhumated priests, paupers, aristocrats, and migrants provide a unique perspective into the interactions between sex and inequality in 18th and 19th century industrial London. Frequencies of caries, dental calculus, periodontal disease, linear enamel hypoplasia, periapical lesions, tuberculosis, treponematosis, rickets, and trauma among 224 females from St. Pancras were compared to 27 low-status females from Crossbones Burial Ground and 74 primarily high-status females from Chelsea Old Church Cemetery. Based on the information known about those buried at St. Pancras, it was hypothesized that the frequencies of health indicators in St. Pancras should fall between the …


Initiating Entrepreneurship To Improve Health Amongst People In Lio Village During The Covid-19 Pandemic: A Qualitative Study, Stella K. Triastari, Angelina Patricia Chandra, Andito M. Wibisono, Dewi Friska Jul 2022

Initiating Entrepreneurship To Improve Health Amongst People In Lio Village During The Covid-19 Pandemic: A Qualitative Study, Stella K. Triastari, Angelina Patricia Chandra, Andito M. Wibisono, Dewi Friska

ASEAN Journal of Community Engagement

Community development in Lio Village performed by Faculty of Medicine Universitas Indonesia students aimed to improve the health status of villagers. Because economy correlates with health, an economic intervention may increase the health status of the people. Based on this, an entrepreneurship program was initiated as a part of a community development program. This study is qualitative study that was conducted between July 2020 and February 2021. The intervention consisted of asynchronous webinar sessions, workshops, and business competition. Data were gathered from post-test questionnaires through a Google form. The winners were chosen according to the business ideas and given …


Social Life Of Females With Persistent Covid-19 Symptoms: A Qualitative Study, Atefeh Aghaei, Ran Zhang, Slone Taylor, Cheuk-Chi Tam, Chih-Hsiang Yang, Xiaoming Li Ph.D., Shan Qiao Ph.D. Jul 2022

Social Life Of Females With Persistent Covid-19 Symptoms: A Qualitative Study, Atefeh Aghaei, Ran Zhang, Slone Taylor, Cheuk-Chi Tam, Chih-Hsiang Yang, Xiaoming Li Ph.D., Shan Qiao Ph.D.

Faculty Publications

Persistent COVID-19 symptoms (long COVID) may bring challenges to long haulers' social lives. Females may endure more profound impacts given their special social roles and existing structural inequality. This study explores the effects of long COVID on the social life of female long haulers. We conducted semi-structured interviews via Zoom between April and June 2021 with 15 female long haulers in the United States, purposely recruited from Facebook and Slack groups and organization websites related to long COVID. Interviews were audio-recorded and transcribed verbatim with consent. The interview data were managed using MAXQDA and examined by thematic analysis. Long COVID …


Cooperative Extension In Urban America: Place-Based Approaches For Improving Health, Dawn Burton, Latoya O'Neal, Erin Yelland, Suzanne Stluka, Rodger Rennekamp Jun 2022

Cooperative Extension In Urban America: Place-Based Approaches For Improving Health, Dawn Burton, Latoya O'Neal, Erin Yelland, Suzanne Stluka, Rodger Rennekamp

Journal of Human Sciences and Extension

While the bulk of Cooperative Extension’s (Extension) historical work has been with rural populations, its future work should also address the needs of those living in urban areas. The opportunity to live a long and healthy life is paramount among those needs. Cooperative Extension’ National Framework for Health Equity and Well-Being (Framework) provides a roadmap by which Cooperative Extension can help ensure that all people have that opportunity. The central premise of the Framework is that future work of Extension must include but extend beyond the promotion of healthy behaviors to place-based approaches for improving conditions in which people live, …


Host Gut Resistome In Gulf War Chronic Multisymptom Illness Correlates With Persistent Inflammation, Dipro Bose, Somdatta Chatterjee, Ethan Older, Ratanesh Seth, Patricia Janulewicz, Punnag Saha, Ayan Mondal, Jeffrey M. Carlson, Alan W. Decho, Kimberly Sullivan, Nancy Kilmas, Stephen Lasley, Jie Li, Saurabh Chatterjee Jun 2022

Host Gut Resistome In Gulf War Chronic Multisymptom Illness Correlates With Persistent Inflammation, Dipro Bose, Somdatta Chatterjee, Ethan Older, Ratanesh Seth, Patricia Janulewicz, Punnag Saha, Ayan Mondal, Jeffrey M. Carlson, Alan W. Decho, Kimberly Sullivan, Nancy Kilmas, Stephen Lasley, Jie Li, Saurabh Chatterjee

Faculty Publications

Chronic multisymptom illness (CMI) affects a subsection of elderly and war Veterans and is associated with systemic inflammation. Here, using a mouse model of CMI and a group of Gulf War (GW) Veterans’ with CMI we show the presence of an altered host resistome. Results show that antibiotic resistance genes (ARGs) are significantly altered in the CMI group in both mice and GW Veterans when compared to control. Fecal samples from GW Veterans with persistent CMI show a significant increase of resistance to a wide class of antibiotics and exhibited an array of mobile genetic elements (MGEs) distinct from normal …


The Cost Of Living In Larger Primate Groups Includes Higher Fly Densities, Jan F. Gogarten, Mueena Jahan, Sébastien Calvignac-Spencer, Colin A. Chapman, Tony L. Goldberg, Fabian H. Leendertz, Jessica M. Rothman Jun 2022

The Cost Of Living In Larger Primate Groups Includes Higher Fly Densities, Jan F. Gogarten, Mueena Jahan, Sébastien Calvignac-Spencer, Colin A. Chapman, Tony L. Goldberg, Fabian H. Leendertz, Jessica M. Rothman

Publications and Research

Flies are implicated in carrying and mechanically transmitting many primate pathogens. We investigated how fly associations vary across six monkey species (Cercopithecus ascanius, Cercopithecus mitis, Colobus guereza, Lophocebus albigena, Papio anubis, and Piliocolobus tephrosceles) and whether monkey group size impacts fly densities. Fly densities were generally higher inside groups than outside them, and considering data from these primate species together revealed that larger groups harbored more flies. Within species, this pattern was strongest for colobine monkeys, and we speculate this might be due to their smaller home ranges, suggesting that movement patterns may influence fly–primate associations. Fly associations increase with …


Law School News: Dr. Fauci Calls On Rwu Graduates To Preserve 'Truth Justice, Diversity And Equality' 05/20/2022, Jill Rodrigues, Roger Williams University School Of Law May 2022

Law School News: Dr. Fauci Calls On Rwu Graduates To Preserve 'Truth Justice, Diversity And Equality' 05/20/2022, Jill Rodrigues, Roger Williams University School Of Law

Life of the Law School (1993- )

No abstract provided.


The Fate Of The Advancing American Kidney Health Initiative In A Biden Administration, Seth Shepherd May 2022

The Fate Of The Advancing American Kidney Health Initiative In A Biden Administration, Seth Shepherd

Journal of the National Association of Administrative Law Judiciary

This article analyzes the Biden Administration’s healthcare priorities, contrasts them with those of the Trump Administration, discusses how Presidential administrations determine whether to continue policies, and examines the proper procedures for continuing previous administration policies. This article will then examine whether the Initiative will have a place in the Biden Administration’s healthcare policy. Part II considers Biden’s overall approach to healthcare. Part III discusses what the Trump Administration’s healthcare policy accomplished. Part IV dissects the Initiative and begins a discussion regarding its effectiveness. Part V explores an administration’s decision-making process regarding retention or rejection of a previous administration’s policies and …


Ageism, Eldercare, And Healthcare: An Examination Of Growing Old In Costa Rica, Akshaya Vijayasankar May 2022

Ageism, Eldercare, And Healthcare: An Examination Of Growing Old In Costa Rica, Akshaya Vijayasankar

Honors Theses

The world’s aging population and the Covid-19 pandemic have revealed the high level of ageism against older adults around the globe, which has resulted in an overall decreased quality of life for elders. Societies are now faced with the challenge of creating a suitable and equitable model of care to support their aging population. Despite the recent publication of the World Health Organization's Global Report on Ageism, there is still a large gap in the literature regarding ageism. This paper addresses the issues of institutional ageism in the eldercare and healthcare sector. I argue that Costa Rica serves as a …


Effects Of Water Quality On Oyster Health On Georgia Coast, Laurel Henderson May 2022

Effects Of Water Quality On Oyster Health On Georgia Coast, Laurel Henderson

Honors College Theses

ABSTRACT

Oysters are an economically and ecologically important shellfish species found along most coastlines. Along the Georgia coastline, oysters form extensive reefs, and are economically important as a food source. In addition, oysters perform a vital role in maintaining water quality due to their high filtration capacity in coastal waters. Oyster reefs form solid, 3-D substrate that prevent coastline erosion and provide structure for numerous other coastal species to grow, including many commercially and recreationally important species. Water quality factors, such as temperature and salinity, can influence oyster density, condition, and growth, and ultimately affect the services the reefs provide …


Pandemic And Substance Use: A Cross-Sectional Analysis, Vanessa E. Ermilio May 2022

Pandemic And Substance Use: A Cross-Sectional Analysis, Vanessa E. Ermilio

Electronic Theses, Projects, and Dissertations

Background: The COVID-19 Pandemic called individuals to stay at home which may have impacted individuals to become not only physically, but socially isolated as well. With social isolation, comes an increase in mental health complications which may lead to an increase in substance use. The purpose of this study was to evaluate the potential association between COVID-19 social isolation and substance use among college students.

Method: The present study’s data was collected from a public, four-year university located in Southern California. The survey was disseminated through instructors at the university and students were incentivized with extra course credit to participate. …


Housing To Health: A Literature Review Analyzing Housing Pathways And Policy Initiatives, Evan P. Lesser May 2022

Housing To Health: A Literature Review Analyzing Housing Pathways And Policy Initiatives, Evan P. Lesser

Capstone Experience: Master of Public Health

Housing is a vital aspect of an individual’s ability to enjoy a healthy lifestyle. It is so integral that the United Nations has stated that housing is a human right and extends beyond just basic shelter where housing should provide a certain level of structural integrity of the infrastructure, security, affordability, and access to surrounding resources. Existing research studying the relationship between housing and health outcomes suggest those with poor housing exhibit higher levels of chronic conditions such as asthma, heart disease, and diabetes, and higher chances of accidents within the home. The goal of this literature review, which has …


Effects Of Feeding Probiotics To Pre-Weaned Dairy Calves, Sara Tomis Apr 2022

Effects Of Feeding Probiotics To Pre-Weaned Dairy Calves, Sara Tomis

Honors Scholar Theses

Pre-ruminant calves are particularly susceptible to pathological and environmental stressors that may have negative effects on their health and growth. Supplementing probiotics to this vulnerable population may have positive implications for the dairy industry, as probiotics may encourage improved growth rates and enhanced health in dairy neonates. However, there is variation in existing literature with regard to effectiveness. This study seeks to explore the impact of dietary probiotic supplement on health and growth parameters in pre-weaned dairy calves. Holstein and Jersey calves (n=30) were assigned to 1 of 2 treatment groups, receiving either 0 or 5 grams of probiotic containing …


Antibody Dependent Enhancement Of Infectious Bronchitis Virus In Poultry, Zachary Hamilton, Barry Simpson, Donald L. Reynolds Apr 2022

Antibody Dependent Enhancement Of Infectious Bronchitis Virus In Poultry, Zachary Hamilton, Barry Simpson, Donald L. Reynolds

UCARE: Research Products

Avian infectious bronchitis (IB) is a coronavirus infection of chickens that causes respiratory disease and reproductive problems in chickens. Currently, there are vaccines that are effective against IB. However, new variants and strains of avian infectious bronchitis virus (IBV) routinely emerge. A vaccine that is not the same strain as the virus is not completely effective in protecting against other variants because the vaccine will not allow the host antibodies to completely neutralize the strain. This is a problem because it makes IB difficult to control and diagnose.

Antibody-dependent enhancement (ADE) is a phenomenon whereby non-neutralizing antibodies, or low levels …