Digital Commons Network^™

The Role Of Dental Hygienists In Conducting Rapid Hiv Testing, Anthony J. Santella, Susan H. Davide, Marilyn Cortell, Winnie Furnari, Janet Tuthill

Publications and Research

Expanding rapid HIV testing in the dental setting may increase the number of individuals who are aware of their HIV status and can begin medical care and social support services if seropositive and appropriate.

Absence Of Antiretroviral Therapy And Other Risk Factors For Morbidity And Mortality In Malaysian Compulsory Drug Detention And Rehabilitation Centers, J.J. Fu, A.R. Bazazi, F.L. Altice, M.N. Mohamed, A. Kamarulzaman

Research Publications (2011 to 2015)

Background: Throughout Asia, people who use drugs are confined in facilities referred to as compulsory drug detention and rehabilitation centers. The limited transparency and accessibility of these centers has posed a significant challenge to evaluating detainees and detention conditions directly. Despite HIV being highly prevalent in this type of confined setting,direct evaluation of detainees with HIV and their access to medical care has yet to be reported in the literature. Methods: We evaluated the health status of 100 adult male detainees with HIV and their access to medical care in the two largest Malaysian compulsory drug detention and rehabilitation centers …

Characterization Of The Infectivity Of Non-Replicating Human Immunodeficiency Virus (Hiv)-Derived Viral Vectors., Vanessa E. Rodriguez, Manuel Llano, Luis Valdes

COURI Symposium Abstracts, Summer 2012

The ability of HIV-derived viral vectors to integrate genes of interest into the host genome causing permanent phenotypic modifications makes them excellent tools in gene therapy. However, integration also causes insertional mutagenesis and controlling integration site selection will increase the biosafety of these molecular tools. HIV DNA integration site selection is influenced by LEDGF/p75, a chromatin-bound cellular protein that interacts with the viral enzyme integrase through the integrase binding domain (IBD). Integrase catalyzes viral DNA integration and non-covalently associates with the HIV genome forming the pre-integration complex (PIC). Therefore, interaction of chromatin-bound LEDGF/p75 with the PIC-associated integrase tethers the HIV …

The School-Based Family: Coaches And Teachers As Parental Figures For Orphans And Vulnerable Children In Ugandan Schools, Angela Warren

Theses and Dissertations

The purpose of this study was to qualitatively examine the possible formation of surrogate families within Ugandan schools to provide a context for positive development experiences, especially for orphans who lack positive development opportunities provided by parents. The sample for this study consisted of 66 Ugandan Secondary School students from eight schools in the Mukono district of Uganda. This study found a potentially widespread family formation pattern between students and their teachers/coaches. More than 75% of students self-identified their teacher and/or coach as family. The results provide insight concerning why orphans and vulnerable children are forming surrogate families with staff …

The Emerging Hiv Epidemic On The Mexico-U.S. Border: An International Case Study Characterizing The Role Of Epidemiology In Surveillance And Response, Steffaine Strathdee, Carlos Magis-Rodriguez, Richard Jimenez

Walden Faculty and Staff Publications

Purpose

Human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome surveillance data are critical for monitoring epidemic trends, but they can mask dynamic subepidemics, especially in vulnerable populations that underuse HIV testing. In this case study, we describe community-based epidemiologic data among injection drug users (IDUs) and female sex workers (FSWs) in two northern Mexico-U.S. border states that identified an emerging HIV epidemic and generated a policy response.

Methods

We draw from quantitative and qualitative cross-sectional and prospective epidemiologic studies and behavioral intervention studies among IDUs and FSWs in Tijuana, Baja California, and Ciudad Juarez, Chihuahua.

Results

The recognition that the HIV epidemic …

Co-Infected Diseases And State Health Policy: Botswana And South Africa's Response To Hiv And Tuberculosis, Margaret H. Schmidt

Lawrence University Honors Projects

The emergence of human immunodeficiency virus (HIV) has led to the growth of co-infection with other illnesses including tuberculosis. Many states are now attempting to address the problems presented with co-infected patients from a variety pathogens. In particular sub-Saharan Africa has suffered exponentially more from HIV and TB co-infection than other parts of the world. Thus, why have Botswana and South Africa not created national health policies to treat these diseases together? The following describes the process of how World Health Organization recommendations are translated into state policy. In turn, while donorship and international policy alterations create strong punctuations, the …

Prioritizing Cd4 Count Monitoring In Response To Art In Resource-Constrained Settings: A Retrospective Application Of Prediction-Based Classification, Livio Azzoni, Andrea S. Foulkes, Yan Liu, Margaret Johnson, Collette Smith, Adeeba Kamarulzaman, Julio Montaner, Karam Mounzer, Michael Saag, Pedro Cahn, Carina Cesar, Alejandro Krolewiecki, Ian Sanne, Luis J. Montaner

Research Publications (2011 to 2015)

Background: Global programs of anti-HIV treatment depend on sustained laboratory capacity to assess treatment initiation thresholds and treatment response over time. Currently, there is no valid alternative to CD4 count testing for monitoring immunologic responses to treatment, but laboratory cost and capacity limit access to CD4 testing in resource-constrained settings. Thus, methods to prioritize patients for CD4 count testing could improve treatment monitoring by optimizing resource allocation. Methods and Findings: Using a prospective cohort of HIV-infected patients (n = 1,956) monitored upon antiretroviral therapy initiation in seven clinical sites with distinct geographical and socio-economic settings, we retrospectively apply a novel …

Role Of Poly [Adp-Ribose] Polymerase 1 In Retroviral Infection, Vanessa E. Rodriguez ^, Manuel Llano *

COURI Symposium Abstracts, Spring 2012

No abstract provided.

Hiv And Aids Education: The Tanzanian Case, Katherine Ellison

Social Sciences

This project takes a look at the cultural, religious, and socio-economic roles that affect the spread of education regarding HIV/AIDS in Tanzania. A personal experience in Zanzibar, Tanzania was the incentive to spark interest in teaching. HIV/AIDS is a powerful epidemic that has taken the lives away from millions. This article takes a deeper look at the transmission, stigmas, and pathways for change.

Strategy For Identifying Dendritic Cell-Processed Cd4+ T Cell Epitopes From The Hiv Gag P24 Protein, Leonia Bozzacco, Haiqiang Yu, Jörn Dengjel

Publications

Mass Spectrometry (MS) is becoming a preferred method to identify class I and class II peptides presented on major histocompability complexes (MHC) on antigen presenting cells (APC). We describe a combined computational and MS approach to identify exogenous MHC II peptides presented on mouse spleen dendritic cells (DCs). This approach enables rapid, effective screening of a large number of possible peptides by a computer-assisted strategy that utilizes the extraordinary human ability for pattern recognition. To test the efficacy of the approach, a mixture of epitope peptide mimics (mimetopes) from HIV gag p24 sequence were added exogenously to Fms-like tyrosine kinase …

Patient- And Population-Level Health Consequences Of Discontinuing Antiretroviral Therapy In Settings With Inadequate Hiv Treatment Availability, April D. Kimmel, Stephen C. Resch, Xavier Anglaret, Norman Daniels, Sue J. Goldie, Christine Daniel, Angela Y. Wong, Kenneth A. Freedberg, Milton C. Weinstein

Health Policy Publications

Background

In resource-limited settings, HIV budgets are flattening or decreasing. A policy of discontinuing antiretroviral therapy (ART) after HIV treatment failure was modeled to highlight trade-offs among competing policy goals of optimizing individual and population health outcomes.

Methods

In settings with two available ART regimens, we assessed two strategies: (1) continue ART after second-line failure (Status Quo) and (2) discontinue ART after second-line failure (Alternative). A computer model simulated outcomes for a single cohort of newly detected, HIV-infected individuals. Projections were fed into a population-level model allowing multiple cohorts to compete for ART with constraints on treatment capacity. In the …

Comparison Of Predicted Susceptibility Between Genotype And Virtual Phenotype Hiv Drug Resistance Interpretation Systems Among Treatment-Naive Hiv-Infected Patients In Asia: Taser-M Cohort Analysis, A. Jiamsakul, R. Kantor, P.C. Li, S. Sirivichayakul, T. Sirisanthana, P. Kantipong, C.K. Lee, A. Kamarulzaman, W. Ratanasuwan, R. Ditangco, T. Singtoroj, S. Sungkanuparph

Research Publications (2011 to 2015)

Background: Accurate interpretation of HIV drug resistance (HIVDR) testing is challenging, yet important for patient care. We compared genotyping interpretation, based on the Stanford University HIV Drug Resistance Database (Stanford HIVdb), and virtual phenotyping, based on the Janssen Diagnostics BVBA’s vircoTYPE™ HIV-1, and investigated their level of agreement in antiretroviral (ARV) naive patients in Asia, where non-B subtypes predominate. Methods: Sequences from 1301 ARV-naive patients enrolled in the TREAT Asia Studies to Evaluate Resistance – Monitoring Study (TASER-M) were analysed by both interpreting systems. Interpretations from both Stanford HIVdb and vircoTYPE™ HIV-1 were initially grouped into 2 levels: susceptible and …

High Diversity Of Cryptosporidium Subgenotypes Identified In Malaysian Hiv/Aids Individuals Targeting Gp60 Gene, Asma Iqbal, Yvonne Ai Lian Lim, Johari Surin, Benedict Lim Heng Sim

Research Publications (2011 to 2015)

Background: Currently, there is a lack of vital information in the genetic makeup of Cryptosporidium especially in developing countries. The present study aimed at determining the genotypes and subgenotypes of Cryptosporidium in hospitalized Malaysian human immunodeficiency virus (HIV) positive patients. Methodology/Principal Findings: In this study, 346 faecal samples collected from Malaysian HIV positive patients were genetically analysed via PCR targeting the 60 kDa glycoprotein (gp60) gene. Eighteen (5.2% of 346) isolates were determined as Cryptosporidium positive with 72.2% (of 18) identified as Cryptosporidium parvum whilst 27.7% as Cryptosporidium hominis. Further gp60 analysis revealed C. parvum belonging to subgenotypes IIaA13G1R1 (2 …

Study Guide For United In Anger: A History Of Act Up, Matt Brim

Open Educational Resources

The United in Anger Study Guide facilitates classroom and activist engagement with Jim Hubbard’s 2012 documentary, United in Anger: A History of ACT UP. The Study Guide contains discussion sections, projects and exercises, and resources for further research about the activism of the New York chapter of ACT UP (AIDS Coalition to Unleash Power). The Study Guide is a free, interactive, multimedia resource for understanding the legacy of ACT UP, the film’s role in preserving that legacy, and its meaning for viewers' lives.

Prognostic Implications Of Oral Health Status In Hiv-Positive Women In St. Petersburg, Russia, Anna Vinogradova

Legacy Theses & Dissertations (2009 - 2024)

Objective: To assess state of oral health in HIV-positive women in St. Petersburg, Russia and to study the association of oral health with pregnancy status and other factors in this sample.

Good Intentions, Bad Consequences: How Congress’S Efforts To Eradicate Hiv/Aids Stifle The Speech Of Humanitarian Organizations, Garima Malhotra

Catholic University Law Review

No abstract provided.

Epidemiology Of Contemporary Seroincident Hiv Infection In The Navy And Marine Corps, David Brett-Major, Shilpa Hakre, Neal A. Naito, Adam Armstrong, Eric A. Bower, Nelson L. Michael, Paul T. Scott

Journal Articles: Epidemiology

Human Immunodeficiency Virus (HIV) infection continues at a steady rate among U.S. Sailors and Marines. This study provides the first service-specific description of HIV infection demographics. All Sailors and Marines identified as HIV infected between January 2005 and August 2010 were included. The project compared personnel and epidemiologic data, and tested reposed sera in the Department of Defense Serum Repository. This group comprised 410 Sailors and 86 Marines, predominantly men. HIV infected Marines were more likely to be foreign born than their Navy counterparts, 42% versus 10%, p < 0.001. Approximately half of the patients had deployed including to the wars in Iraq or Afghanistan. Nearly half of each group was infected by the age of 25. Similar to the U.S. epidemic, Black race was over-represented. Unlike national rates, Hispanic Sailors and Marines were not over-represented. Demographics were distinct for those of specific occupational specialties. Certain ship classes carried lower incidences. Clustering of HIV infection risk occurred around deployment. The Navy and Marine Corps have different patterns of HIV infection, which may merit distinct approaches to prevention. The Navy may have unique targets for prevention efforts to include pipeline training and first assignment as well as particular occupational environments.

With Child, Without Rights?: Restoring A Pregnant Woman's Right To Refuse Medical Treatment Through The Hiv Lens, Michael Ulrich

Faculty Scholarship

In Doe v. Division of Youth & Family Services , a hospital employee sought state intervention when an HIV-positive woman refused to comply with treatment recommendations during her pregnancy to drastically reduce the chances of mother-to-child-transmission (MTCT), eventually triggering a lawsuit against the hospital. With an increase in the number of HIV-positive women becoming pregnant and the court avoiding constitutional analysis of the woman’s right to refuse medical treatment, there is a clear void where legal analysis is surely needed. This Article fills this void for the inevitable case where an HIV-positive pregnant woman’s right to refuse medical treatment is …

The Effect Of Combined Moderate-Intensity Training On Immune Functioning, Metabolic Variables, And Quality Of Life In Hiv-Infected Individuals Receiving Highly Active Antiretroviral Therapy, Eduard Tiozzo

Open Access Dissertations

Highly-active antiretroviral therapy (HAART) has improved the prognosis of HIV-infected individuals. Unfortunately it has also been associated with impaired functional capacity and development of metabolic perturbations which increases health risk. This study tested the hypothesis that a combined cardiorespiratory and resistance exercise training (CARET) intervention may result in significant health benefits in HIV-infected individuals receiving HAART. Thirty-seven HIV-infected men and women, predominantly of lower socioeconomic status (SES), were recruited and randomly assigned to: 1) a group of moderate-intensity CARET for three months or 2) a control group receiving no exercise intervention for three months. At baseline and following the intervention, …

Functional Recovery Of Untreated Human Immunodeficiency Virus-Associated Guillain-Barré Syndrome: A Case Report, Adam L. Schreiber, John W. Norbury Iii, Eduardo A. De Sousa

Department of Rehabilitation Medicine Faculty Papers

HIV-associated Guillain-Barré Syndrome is a well-documented phenomenon, typically occurring at seroconversion. GBS may result in functional impairment treated with a combination of medications, plasmapheresis, and rehabilitation. The quantified functional recovery of HIV-associated GBS with or without HIV treatment is not well-described. Utilizing serial FIM scoring, we describe a patient’s recovery from HIV-associated GBS after treatment with IVIg and acute inpatient rehabilitation without HIV treatment.

Hiv And Concurrent Sexual Partnerships: Modelling The Role Of Coital Dilution, Larry Sawers, Alan G. Isaac, Eileen Stillwaggon

Economics Faculty Publications

Background: The concurrency hypothesis asserts that high prevalence of overlapping sexual partnerships explains extraordinarily high HIV levels in sub-Saharan Africa. Earlier simulation models show that the network effect of concurrency can increase HIV incidence, but those models do not account for the coital dilution effect (nonprimary partnerships have lower coital frequency than primary partnerships).

Methods: We modify the model of Eaton et al (AIDS and Behavior, September 2010) to incorporate coital dilution by assigning lower coital frequencies to non-primary partnerships. We parameterize coital dilution based on the empirical work of Morris et al (PLoS ONE, December …

The Implications Of Male Circumcision On Hiv Transmission, Aliciamarie Hurlburt

Pell Scholars and Senior Theses

Human immunodeficiency virus (HIV) is one of the world’s biggest health threats. In 2010, 33.3 million adults and children were predicted to be living with HIV/AIDS. Although prevention methods such as abstinence, condoms, and fewer sexual partners will help to lower the number of people infected by HIV, they are not enough. Male circumcision may provide an extra prevention method to acquiring HIV. A correlation between male circumcision and HIV transmission was first discovered in areas in western and northern Africa where the male circumcision prevalence rates tend to be high and HIV prevalence tends to be low. The foreskin …

Roles Of Autophagy In Hiv-1 Infection, Christina Archer Dinkins

Biomedical Sciences ETDs

Human immunodeficiency virus type 1 (HIV-1) chronically infects approximately 30 million people worldwide. HIV-1 has become one of the most difficult viral infections to treat due to its high mutability and emerging drug resistance. Critical to our development of more effective therapeutic treatments, we must better understand the HIV life cycle in order to reveal better targets for drug development. Thus, the purpose of this work was to investigate the role of autophagy, a cellular homeostatic mechanism capable of eliminating intracellular pathogens, in HIV-1 infection of two relevant hosts, the human and the Old World non-permissive primate, the rhesus macaque. …

A Methodology For Building Culture And Gender Norms Into Intervention: An Example From Mumbai, India, Kristin M. Kostick,, Stephen L. Schensul, Pertti Pelto

UCHC Articles - Research

This paper responds to the call for culturally relevant intervention research by introducing a methodology for identifying community norms and resources in order to more effectively implement sustainable interventions strategies. Results of an analysis of community norms, specifically attitudes toward gender equity, are presented from an HIV/STI research and intervention project in a low income community in Mumbai, India (2008–2012). Community gender norms were explored because of their relevance to sexual risk in settings characterized by high levels of gender inequity. This paper recommends approaches that interventionists and social scientists can take to incorporate cultural insights into formative assessments and …

C-C Chemokine Receptor 5 And Hiv: Therapeutic Potentials Of The Δ32 Base Pair Deletion, Amanda R. Antczak

Honors Projects

The human immunodeficiency virus, a retrovirus discovered in 1981, has reached pandemic status worldwide. Without an existing cure or vaccine, a majority of the world’s population remains at risk for infection and more than 35 million people to date have died from AIDS. Resistance to the virus, however, has been discovered in about 10% of the world’s population in the form of an allelic base pair deletion, located on C-C chemokine receptor 5. Those homozygous for the base pair deletion are resistant to HIV, while heterozygotes have displayed delayed onset of HIV infection. The CCR5 mutation and observed resistance to …

Unmasking Immune Reconstitution Inflammatory Syndrome (Iris) : A Report Of Five Cases And Review Of The Literature, Abdullah Balkhair, Sudheer Ahamed, Dilip

Sultan Qaboos University Medical Journal

Immune reconstitution inflammatory syndromes (IRIS) in patients with acquired immune deficiency syndrome (AIDS) are characterised by atypical manifestations of opportunistic pathogens. These occur in patients experiencing improvement in CD4 cell counts following receipt of highly active anti-retroviral therapy (HAART). Although well established as a syndrome, IRIS still presents challenges in diagnosis and management. We report five cases of IRIS with diverse clinical presentations and due to different infectious aetiologies. A review of the published literature on this syndrome is also included.

Uganda And The Current Hiv Treatment Crisis - A Perspective, Ellen J. Plumb Md

Population Health Matters (Formerly Health Policy Newsletter)

No abstract provided.

Comparative Gender Analysis Of The Efficacy And Safety Of Atazanavir/Ritonavir And Lopinavir/Ritonavir At 96 Weeks In The Castle Study., Kathleen E Squires, Margaret Johnson, Rong Yang, Jonathan Uy, Louise Sheppard, Judith Absalon, Donnie Mcgrath

Department of Medicine Faculty Papers

OBJECTIVES: To examine whether the overall results of the CASTLE study pertain to both genders, we analysed the efficacy and safety of atazanavir/ritonavir and lopinavir/ritonavir in 277 female and 606 male patients in the open-label, multinational trial over 96 weeks. The trial is registered with ClinicalTrials.gov, number NCT00272779.

METHODS: Treatment-naive patients aged ≥ 18 years with HIV-1 RNA ≥ 5000 copies/mL were randomized to receive either atazanavir/ritonavir 300/100 mg once daily or lopinavir/ritonavir 400/100 mg twice daily, with fixed-dose tenofovir/emtricitabine 300/200 mg once daily.

RESULTS: At week 96, confirmed virological response rates (HIV RNA <50 copies>/mL; intent-to-treat analysis) were higher in …

The Social Determinants Of Hiv/Aids In Cambodia: Is It Too Early To Call Micro Medical Efforts A Success?, Matthew Aaron Sherwood

Electronic Theses and Dissertations

Cambodia, a least developed country (LDC) with a recent history of civil war and genocide, has been widely considered to be a success story when it comes to the fight against HIV/AIDS. Within a few years of the first HIV positive blood test in the kingdom in 1991, it quickly became the country with the highest prevalence in the region, with estimates of as many as 4% of the population being infected at one point.

In recent years, Cambodia's HIV/AIDS infection rates have plummeted to below 1%, with most of the credit being given to the implementation of micro-medical measures, …

Immunization With Hiv Gag Targeted To Dendritic Cells Followed By Recombinant New York Vaccinia Virus Induces Robust T-Cell Immunity In Nonhuman Primates, Barbara J. Flynn, Kathrin Kastenmüller, Ulrike Wille-Reece

Publications

Protein vaccines, if rendered immunogenic, would facilitate vaccine development against HIV and other pathogens. We compared in nonhuman primates (NHPs) immune responses to HIV Gag p24 within 3G9 antibody to DEC205 ("DEC-HIV Gag p24"), an uptake receptor on dendritic cells, to nontargeted protein, with or without poly ICLC, a synthetic double stranded RNA, as adjuvant. Priming s.c. with 60 ?g of both HIV Gag p24 vaccines elicited potent CD4⁺ T cells secreting IL-2, IFN-γ, and TNF-α, which also proliferated. The responses increased with each of three immunizations and recognized multiple Gag peptides. DEC-HIV Gag p24 showed better cross-priming for …