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The Role Of Speech-Language Pathologists In Swallowing Treatment Of Individuals With Hiv/Aids, Sarah Lynn Warner

Online Theses and Dissertations

The role of speech-language pathologists (SLPs) in the assessment and treatment of dysphagia in individuals living with HIV/AIDS is relatively absent from the literature. Dysphagia is described as difficulty swallowing that can be caused by oral indicators, structural dysfunction, and neurological disease (Bladon & Ross, 2007; Bobba et al., 2007; Nkuize et al., 2010). Dysphagia is a prevalent symptom secondary to the HIV/AIDS virus, yet dysphagia in the HIV/AIDS population often goes untreated (Bladon & Ross, 2007). One way to improve assessment and treatment of dysphagia is to ensure medical professionals are knowledgeable of the communication and swallowing disorders that …

Exploring Unprotected Anal Intercourse Among Newly Diagnosed Hiv Positive Men Who Have Sex With Men In China: An Ethnographic Study, Haochu Li, Eleanor Holroyd, Joseph Lau

School of Nursing & Midwifery, East Africa

Background: Unprotected anal intercourse (UAI) is a major pathway towards secondary HIV transmission among men who have sex with men (MSM). We explored the socio-cultural environment and individual beliefs and experiences conducive to UAI in the context of Southern China.

Methods: We employed an ethnographic approach utilizing a socio-ecological framework to conduct repeated in-depth interviews with thirty one newly diagnosed HIV positive MSM as well as participant observations in Shenzhen based healthcare settings, MSM venues and NGO offices.

Results: Some men (6/31) reported continuing to practice UAI after an initial diagnosis of being HIV positive. For MSM who had existing …

Enhancement Of The Placental Transmission Of Lopinavir Using A Transporter Targeted Prodrug Strategy, Meng Wang

Theses and Dissertations

Lopinavir (LPV) is a potent protease inhibitor specific for HIV-1. However, LPV has poor placental penetration due to substrate activity for efflux transporter by P-glycoprotein (P-gp). Since fatty acid transporters are highly expressed in the placenta during pregnancy, we designed fatty acid ester prodrug of lopinavir as substrates of fatty acid transporter in order to improve their uptake into placenta. Seven dicarboxylic acid esters of lopinavir have been made in our lab. The structures were characterized by ¹H-NMR, ¹³C-NMR, LC-MS/MS, HRMS, IR and melting points. After making the prodrugs, an LC-MS/MS method with high specificity and sensitivity, as …

Social Network Correlates Of Hcv And Hiv Transmission Risk Behaviors Among Injecting Drug Users, Victor Emanuel Reyes-Ortiz

Walden Dissertations and Doctoral Studies

Drug injection is an increasingly important risk factor in the transmission of blood-borne pathogens, including the hepatitis C virus (HCV) and human immunodeficiency virus (HIV). The purpose of the study was to examine the influence of social network factors on HCV and HIV. The study was grounded in social network theory and sought to determine whether social network characteristics affect high-risk sexual and drug injection behavior as well as self-reported HIV and HCV status. The study design was a quantitative cross-sectional survey. A total of 181 participants in a needle exchange program completed a survey in Spanish assessing individual drug …

The Impact Of A Community-Based Hiv And Sexual Reproductive Health Program On Sexual And Healthcare-Seeking Behaviors Of Female Entertainment Workers In Cambodia, Siyan Yi, Sovannary Tuot, Pheak Chhoun, Carinne M. Brody, Khimuy Tith, Sopheap Oum

Background: In Cambodia, despite great successes in the fight against HIV, challenges remain to eliminating new HIV infections and addressing sexual reproductive health (SRH) issues in key populations including female entertainment workers (FEWs). To address these issues, the Sustainable Action against HIV and AIDS in Communities (SAHACOM) project has been implemented since late 2009 using a community-based approach to integrate HIV and SRH services. This study evaluates the impact of the SAHACOM on sexual and healthcare-seeking behaviors among FEWs in Cambodia.

Methods: A midterm and endpoint comparison design was utilized. Midterm data were collected in early 2012, and …

Interventions To Promote Adherence To Antiretroviral Therapy In Africa: A Network Meta-Analysis, Edward J. Mills, Richard Lester, Kristian Thorlund, Maria Lorenzi, Katherine Muldoon, Steve Kanters, Sebastian Linnemayr, Robert Gross, Yvette Calderon, K Rivet Amico, Harsha Thirumurthy, Cynthia Pearson, Robert H. Remien, Lawrence Mbuagbaw, Lehana Thabane, Michael Chung, Ira B. Wilson, Albert Liu, Olalekan A. Uthman, Jane Simoni, David Bangsberg, Sanni Yaya, Till Bärnighausen, Nathan Ford, Jean B. Nachega

Internal Medicine, East Africa

Background: Adherence to antiretroviral therapy (ART) is necessary for the improvement of the health of patients and for public health. We sought to determine the comparative effectiveness of different interventions for improving ART adherence in HIV-infected people living in Africa.

Methods: We searched for randomised trials of interventions to promote antiretroviral adherence within adults in Africa. We searched AMED, CINAHL, Embase, Medline (via PubMed), and ClinicalTrials.gov from inception to Oct 31, 2014, with the terms “HIV”, “ART”, “adherence”, and “Africa”. We created a network of the interventions by pooling the published and individual patients' data for comparable treatments and comparing …

Intimate Partner Violence After Disclosure Of Hiv Test Results Among Pregnant Women In Harare, Zimbabwe, Simukai Shamu, Christina Zarowsky, Tamara Shefer, Marleen Temmerman, Naeemah Abrahams

Obstetrics and Gynaecology, East Africa

Background: HIV status disclosure is a central strategy in HIV prevention and treatment but in high prevalence settings women test disproportionately and most often during pregnancy. This study reports intimate partner violence (IPV) following disclosure of HIV test results by pregnant women.

Methods: In this cross sectional study we interviewed 1951 postnatal women who tested positive and negative for HIV about IPV experiences following HIV test disclosure, using an adapted WHO questionnaire. Multivariate regression models assessed factors associated with IPV after disclosure and controlled for factors such as previous IPV and other known behavioural factors associated with IPV.

Results: Over …

Hiv-1 Transgenic Rats Display Alterations In Immunophenotype And Cellular Responses Associated With Aging, Susan J. Abbondanzo

Seton Hall University Dissertations and Theses (ETDs)

Advances in anti-retroviral therapy over the last two decades have allowed life expectancy in patients infected with the human immunodeficiency virus to approach that of the general population. The process of aging in mammalian species, including rats, results in changes with immune response, immunological phenotypes, and ultimately, increased susceptibility to many infectious diseases. In order to investigate the immunological pathologies associated with chronic HIV-1 disease, particularly in aged individuals, the HIV-1 transgenic (HIV-1Tg) rat model was utilized. Age matched animals were challenged using lipopolysaccharide (LPS) to determine immunological modification of HIV-1Tg animals throughout the aging process. LPS is known to …

Lack Of Awareness Of Human Immunodeficiency Virus (Hiv) Infection: Problems And Solutions With Self-Reported Hiv Serostatus Of Men Who Have Sex With Men, Travis H. Sanchez, Colleen F. Kelley, Eli Rosenberg, Nicole Luisi, Brandon O'Hara, Rodriques Lambert, Raphael Coleman, Paula M. Frew, Laura F. Salazar, Sijia Tao, William Clarke, Carlos Del Rio, Patrick S. Sullivan

Environmental & Global Health Faculty Research

Background. Lack of human immunodeficiency virus (HIV) infection awareness may be a driver of racial disparities in HIV infection among men who have sex with men (MSM). Lack of awareness is typically measured by comparing HIV test result to self-reported HIV status. This measure may be subject to reporting bias and alternatives are needed.Methods. The InvolveMENt study examined HIV disparities between black and white MSM from Atlanta. Among HIV-positive participants who did not report knowing they were positive, we examined other measures of awareness: … See full text for complete abstract.

Mathematical Analysis Of The Transmission Dynamics Of Hiv/Aids: Role Of Female Sex Workers, Navjot Kaur, Mini Ghosh, S. S. Bhatia

Applied Mathematics & Information Sciences

The transmission of ’Human Immunodeficiency Virus (HIV)’ that causes the ‘Acquired Immunodeficiency Syndrome (AIDS)’ is strongly associated with un-protected sex and at the present understanding this epidemic can reach higher prevalence threshold level when there are extensive sexual contacts between the sex workers and general population. In the present work, we investigate a nonlinear model for studing the transmission dynamics of HIV/AIDS epidemic with emphasis on the role of female sex workers. Here, we consider only the heterosexual transmissions of HIV/AIDS and formulate the mathematical model by dividing the total adult population under consideration into three different classes: male, female …

Newsroom, Georgia Southern University

Newsroom (2006-2023)

• HIV Conference to Bring New Strategies to Rural Health Care

Women’S Hiv Prevention Study (Whips): A Proposal To Pilot Test An Hiv Intervention For Older African American Women Living With Hiv, Charsey Cherry

Theses and Dissertations

Despite improvements in treatments over the past 30 years, HIV /AIDS continues to be a major public health threat, particularly among sub-populations such as African American women. Midlife and older adults (those aged 40 years and over) are fast becoming a growing concern for HIV/AIDS infections, particularly older African American women. There has been limited research targeting midlife and older African American women living with HIV that aimed to reduce their transmission of HIV and promote them becoming prevention advocates. In response to this gap in the literature, a culturally tailored intervention guided by the IMB Model of behavior change …

“Work What You Got”: Political Participation And Hiv-Positive Black Women’S Work To Restore Themselves And Their Communities, Monica L. Melton

Journal of Interdisciplinary Feminist Thought

Black women’s rates of HIV/AIDS infection have skyrocketed in comparison to other racial and ethnic groups over the past thirty years. Despite these rates, HIV-positive Black women’s perspectives are rarely sought regarding best practices to eradicate and interrupt HIV/AIDS among African American women, even though historically Black women have often proved phenomenal agents of social change. HIV-positive Black women’s activism has been understudied and input from the community in crisis has rarely been deemed as valuable to public health officials in HIV/AIDS prevention and interventions. Through the narratives of thirty HIV-positive Floridian Black women, I present HIV-positive Black women’s political …

The Impact Of Alcohol On Hiv Prevention And Treatment For South Africans In Primary Healthcare, Michelle Schneider, Matthew Chersich, Marleen Temmerman, Olivier Degomme, Charles D. Parry

Obstetrics and Gynaecology, East Africa

Background: Antiretroviral treatment (ART) has substantially reduced morbidity and mortality for HIV patients. In South Africa, with the largest ART programme globally, attention is needed not only on the further expansion of ART coverage, but also on factors which undermine its effectiveness, such as alcohol use.

Objective: Given the decentralised approach of nurse-initiated and -sustained ART in the South African primary health sector, it is important to document key aspects of alcohol use to be conveyed to HIV-positive individuals and those at risk for HIV.

Method: This study comprised a narrative review of relevant literature.

Results: Alcohol acts through both …

Hiv-Positive Parents, Hiv-Positive Children, And Hiv-Negative Children’S Perspectives On Disclosure Of A Parent’S And Child’S Illness In Kenya, Grace Gachanja, Gary J. Burkholder Jr, Aimee Ferraro

Walden Faculty and Staff Publications

HIV disclosure from parent to child is complex and challenging to HIV-positive parents and healthcare professionals. The purpose of the study was to understand the lived experiences of HIV-positive parents and their children during the disclosure process in Kenya. Sixteen HIV-positive parents, seven HIV-positive children, and five HIV-negative children completed semistructured, in-depth interviews. Data were analyzed using the Van Kaam method; NVivo 8 software was used to assist data analysis. We present data on the process of disclosure based on how participants recommended full disclosure be approached to HIV-positive and negative children. Participants recommended disclosure as a process starting at …

The Revolving Door Pattern Of Jail Incarceration And Homelessness And Its Influence On Mortality And Morbidity Among New York City Adults, Sungwoo Lim

Dissertations, Theses, and Capstone Projects

Objectives

The purpose of this dissertation study was to identify timing and sequencing of jail incarceration and homelessness by utilizing sequence analysis and to test whether a particular trajectory contributes to mortality risk and discontinuity of HIV care.

Methods

The main data source was an existing matched dataset, constructed using administrative data from the New York City (NYC) Departments of Health and Mental Hygiene, Correction, and Homeless Services. The study cohort consisted of 15,620 NYC adults with recent histories of both jail incarceration and homelessness. Monthly experiences of jail incarceration, homelessness, and community-dwelling in 2001-03 were summarized into trajectory groups …

Hiv And Sti Risk For Young Blacks In High Prevalence Areas: Implications For Health Equity In Communities Hosting Historically Black Colleges And Universities (Hbcus), Tanya Telfair Leblanc, Madeline Y. Sutton, Peter Thomas, Wayne A. Duffus

Journal of Health Disparities Research and Practice

Background

Every year, thousands of young, black, high school graduates who are seeking higher education, attend one of the 105 historically black colleges and universities (HBCUs) located primarily in the south and east. The objective of the research was to examine the geographic proximity of HBCUs to areas of high HIV and STI disease burden among college age people to assess infectivity of potential sex partners in the areas surrounding HBCUs.

Methods

We examined the 14 states reporting the greatest HIV diagnoses burden among persons age 20-24 years old and STI burden among persons age 15 to 24 years old …

Hiv Infection: Solitary Work, Silent Suffering Beliefs About Responsibility For Health And The Ability To Impact Disease Progression, Cynthia A. Frank

Doctoral Dissertations

HIV Infection: Solitary Work, Silent Suffering

Beliefs about Responsibility for Health

and the Ability to Impact Disease Progression

Cynthia Frank, PhD

University of Connecticut 2014

In contemporary Western society, health has become a personal and moral responsibility. People are blamed for their unhealthy or risky behavior and for acquiring certain diseases according to socially and culturally constructed norms. HIV is an infectious disease that is imbued with moral overtones and stigma, often multidimensional, creating an illness in which responsibility (for acquisition, transmission, and viral suppression) is an overarching theme. Thus, it represents a unique vehicle for exploring belief systems related …

Placental Hpv Infection In Hiv Positive And Hiv Negative Zambian Women, Chrispin Chisanga

School of Biological Sciences: Dissertations, Theses, and Student Research

Human papillomaviruses (HPVs) have been reported to infect epithelial trophoblastic cells of the placenta, induce cell death and even cause placental malfunction associated with spontaneous preterm delivery. To date, no study has been conducted to determine the role of HIV on HPV genotype distribution and pathogenesis in the placental compartment. This is despite the evidence that the human immunodeficiency virus (HIV) can decrease the cellular immune response and increase the incidence of malignant cancers in HPV patients. Therefore, in this study, we analyzed 200 genomic DNA (gDNA) samples extracted from paraffin embedded placental tissues of HIV positive and HIV negative …

Dynamic Social Support Networks Of Younger Black Men Who Have Sex With Men With New Hiv Infection, Dexter R. Voisin

Faculty Scholarship

Rising rates of HIV infection among younger black men who have sex with men (YBMSM) in the USA have generated a public health emergency. Living with HIV requires deep and persistent social support often available only from close confidants. Enlisting endogenous support network members into the care of HIV-infected YBMSM may help shape sustainable supportive environments, leading to long-term improvements in mental and HIV-specific health outcomes. The present study examined trends in support network change over time after new HIV diagnoses among 14 YBMSM. Participants completed a social network survey that utilized sociograms to record support confidants (SCs) preceding HIV …

Hiv In The Immune System: The Role Of Specialized Follicular Dendritic Cells In Promoting Viral Disease, Jacob D. Estes, Dr. Gregory F. Burton

Journal of Undergraduate Research

Human Immunodeficiency Virus (HIV) has become a world wild epidemic affecting millions of people across the globe. Even in the face of potent antiviral drugs which are only available in first world countries, HIV continues to evade intervention strategies and eventually destroy the body’s immune system. During the longest stage of HIV disease, clinical latency, much of active infection is confined to the germinal centers of secondary lymphoid tissue (1). Here HIV is trapped on the surface of follicular dendritic cells (FDC) which reside in this region of all secondary lymphoid organs (2). Large amounts of HIV localize on FDC …

Tcd4+ Lymphocyte Are Related To Muscle Strength Parameters In Hiv-1 Positive Adolescents: A Preliminary Study, Erik D. Hanson, Fabio H. Ornellas, Claudio L. Battaglini, Reury F P Bacurau, Alan J P Moraes, Magnus Benetti, Marinella D. Negra, Carmen Lp Lancellotti

International Journal of Exercise Science: Conference Proceedings

Introduction: Catabolism of muscle and loss of function are complications that can occur during the course of HIV infection, and are commonly seen in a majority of adolescents with vertically transmitted Human Immunodeficiency Virus-type 1 (HIV-1). The levels of CD4+ and CD8+ lymphocytes, reference markers for the treatment of vertically transmitted HIV-1, also decline as the disease progresses. Alterations on these reference markers may be associated with neuromuscular force parameters in sedentary adolescents that have potential as prognostic indicators for treatment administration. Objective: To investigate the relationship between maximal isometric muscular contraction force and levels of CD4+ and CD8+ lymphocytes …

Acute Cranial Neuropathies Heralding Neurosyphilis In Human Immunodeficiency Virus-Infected Patient., Saeed Alqahtani

Neurology Faculty Publications

No abstract provided.

Developing Clinical Strength-Of-Evidence Approach To Define Hiv-Associated Malignancies For Cancer Registration In Kenya, Anne Korir, Nathan Mauti, Pamela Moats, Matthew J. Gurka, Geoffrey Mutuma, Christine Metheny, Peter M. Mwamba, Peter O. Oyiro, Melanie Fisher, Leona W. Ayers, Rosemary Rochford, Walter O. Mwanda, Scot C. Remick

Faculty & Staff Scholarship

Background

Sub-Saharan Africa cancer registries are beset by an increasing cancer burden further exacerbated by the AIDS epidemic where there are limited capabilities for cancer-AIDS match co-registration. We undertook a pilot study based on a “strength-of-evidence” approach using clinical data that is abstracted at the time of cancer registration for purposes of linking cancer diagnosis to AIDS diagnosis.

Methods/Findings

The standard Nairobi Cancer Registry form was modified for registrars to abstract the following clinical data from medical records regarding HIV infection/AIDS in a hierarchal approach at time of cancer registration from highest-to-lowest strength-of-evidence: 1) documentation of positive HIV serology; 2) …

Antifibrotic Therapy In Simian Immunodeficiency Virus Infection Preserves Cd4+ T-Cell Populations And Improves Immune Reconstitution With Antiretroviral Therapy, Jacob D. Estes, Cavan Reilly, Charles M. Trubey, Courtney V. Fletcher, Theodore J. Cory, Michael Piatak Jr., Samuel Russ, Jodi Anderson, Thomas G. Reimann, Robert Star, Anthony Smith, Russell P. Tracy, Anna Berglund, Thomas Schmidt, Vicky Coalter, Elena Chertova, Jeremy Smedley, Ashley T. Haase, Jeffrey D. Lifson, Timothy W. Schacker

United States Public Health Resources

Even with prolonged antiretroviral therapy (ART), many human immunodeficiency virus-infected individuals have CD4⁺ T cells/μL, and CD4⁺ T cells in lymphoid tissues remain severely depleted, due in part to fibrosis of the paracortical T-cell zone (TZ) that impairs homeostatic mechanisms required for T-cell survival.We therefore used antifibrotic therapy in simian immunodeficiency virus-infected rhesus macaques to determine whether decreased TZ fibrosis would improve reconstitution of peripheral and lymphoid CD4⁺ T cells. Treatment with the antifibrotic drug pirfenidone preserved TZ architecture and was associated with significantly larger populations of CD4⁺ T cells in peripheral blood and lymphoid tissues. …

Delayed-Type Hypersensitivity And Hepatitis B Vaccine Responses, In Vivo Markers Of Cellular And Humoral Immune Function, And The Risk Of Aids Or Death, Shane B. Patterson, Michael L. Landrum, Jason F. Okulicz

Uniformed Services University of the Health Sciences

Background: Delayed-type hypersensitivity (DTH) test responsiveness is associated with HIV disease progression; however it is unknown whether other immune markers, such as hepatitis B virus (HBV) vaccine seroresponse, also predict HIV outcomes. Methods: Eligible participants received HBV vaccine after HIV diagnosis, had non-anergic DTH testing at the time of last HBV vaccination, and available post-vaccine HBV antibody responses. The risk of progression to AIDS or death from the time of last HBV vaccination was evaluated. Results: Of 369 eligible participants with non-anergic DTH responses, 148 (40%) were HBV vaccine responders. In a multivariate model adjusted for age, CD4 count, …

Residual Disease And Hpv Persistence After Cryotherapy For Cervical Intraepithelial Neoplasia Grade 2/3 In Hiv Positive Women In Kenya, Hugo De Vuyst, Nelly R. Mugo, Silvia Franceschi, Kevin Mckenzie, Vanessa Tenet, Julia Njoroge, Farzana S. Rana, Samah R. Sakr, Peter J.F. Snijders, Michael Chung

Pathology, East Africa

Objective: To assess residual cervical intraepithelial neoplasia (CIN) 2/3 disease and clearance of high-risk (hr) human papillomavirus (HPV) infections at 6 months after cryotherapy among HIV-positive women.

Design: Follow-up study.

Methods: 79 HIV-positive women received cryotherapy for CIN2/3 in Nairobi, Kenya, and underwent conventional cytology 6 months later. Biopsies were performed on high grade cytological lesions and hrHPV was assessed before (cervical cells and biopsy) and after cryotherapy (cells).

Results: At 6 months after cryotherapy CIN2/3 had been eliminated in 61 women (77.2%; 95% Confidence Interval, (CI):66.4–85.9). 18 women (22.8%) had residual CIN2/3, and all these women had hrHPV at …

Identifying Factors Associated With The Uptake Of Prevention Of Mother To Child Hiv Transmission Programme In Tigray Region, Ethiopia: A Multilevel Modeling Approach, Wondwossen Lerebo, Steven Callens, Debra Jackson, Christina Zarowsky, Marleen Temmerman

Obstetrics and Gynaecology, East Africa

Background: Prevention of mother to child HIV transmission (PMTCT) remains a challenge in low and middle-income countries. Determinants of utilization occur – and often interact - at both individual and community levels, but most studies do not address how determinants interact across levels. Multilevel models allow for the importance of both groups and individuals in understanding health outcomes and provide one way to link the traditionally distinct ecological- and individual-level studies. This study examined individual and community level determinants of mother and child receiving PMTCT services in Tigray region, Ethiopia.

Methods: A multistage probability sampling method was used for this …

Medication Use And Patients Co-Infected With Human Immunodeficiency Virus And Hepatitis C Virus : Quantifying The Prevalence And Identifying The Predictors Of Clinically Significant Drug-Drug Interactions Associated With Therapy Containing First Generation Non-Structural 3a Serine Protease Inhibitors, Nimish Patel

Legacy Theses & Dissertations (2009 - 2024)

This dissertation enhances our understanding of clinically significant drug-drug interactions (CSDDIs) and contraindicated drug interactions among patients with human immunodeficiency virus (HIV) and hepatitis C virus (HCV) coinfection before and after the addition of HCV therapy including first generation non-structural (NS) 3A serine protease inhibitors. This is important to understand because the clinical sequelae of untreated chronic HCV infection are devastating yet drug-drug interactions greatly complicate treatment for these patients. The HIV/HCV coinfected population is a population that is particularly vulnerable because they are using a high volume of medications. Specifically, the standard of care for patients with HIV infection …

Maternal Characteristics And Factors Associated With Hepatitis C (Hcv) Infection Among Hiv-Positive Pregnant Women In Ukraine, 2010-2011, Liudmyla Slobodianyk

Legacy Theses & Dissertations (2009 - 2024)

Objective: Determine the association between risk factors for Hepatitis C and hepatitis C (HCV) infection among HIV-positive pregnant women in Ukraine.