Open Access. Powered by Scholars. Published by Universities.®
- Discipline
-
- Medicine and Health Sciences (11883)
- Medical Specialties (6788)
- Medical Sciences (5239)
- Life Sciences (2840)
- Oncology (2237)
-
- Biomedical Informatics (1967)
- Public Health (1826)
- Bioinformatics (1752)
- Medical Genetics (1638)
- Genetic Phenomena (1342)
- Diseases (1318)
- Pediatrics (1042)
- Social and Behavioral Sciences (908)
- Cardiology (568)
- Neurology (513)
- Obstetrics and Gynecology (511)
- Mental and Social Health (456)
- Neurosciences (406)
- Medical Molecular Biology (391)
- Psychology (381)
- Cardiovascular Diseases (364)
- Surgery (325)
- Endocrinology, Diabetes, and Metabolism (324)
- Internal Medicine (315)
- Epidemiology (309)
- Psychiatry and Psychology (292)
- Health Services Research (265)
- Analytical, Diagnostic and Therapeutic Techniques and Equipment (261)
- Women's Health (256)
- Biological Phenomena, Cell Phenomena, and Immunity (253)
- Institution
-
- The Texas Medical Center Library (5913)
- Washington University School of Medicine (2323)
- Thomas Jefferson University (1222)
- University of Kentucky (600)
- Children's Mercy Kansas City (590)
-
- Western University (385)
- Dartmouth College (288)
- University of Nebraska Medical Center (267)
- University of Plymouth (204)
- The Jackson Laboratory (175)
- Henry Ford Health (168)
- University of New Mexico (138)
- OhioHealth (136)
- Old Dominion University (136)
- Providence (124)
- Edith Cowan University (116)
- Rowan University (102)
- University of South Carolina (87)
- Himmelfarb Health Sciences Library, The George Washington University (78)
- University of Dayton (46)
- Southern Illinois University Carbondale (45)
- Philadelphia College of Osteopathic Medicine (42)
- Wright State University (41)
- University of Malaya (37)
- Walden University (36)
- University of Nevada, Las Vegas (30)
- Parkview Health (29)
- University of South Florida (29)
- Utah State University (29)
- South Dakota State University (28)
- Publication Year
- Publication
-
- Faculty, Staff and Student Publications (3390)
- 2020-Current year OA Pubs (1947)
- Faculty, Staff and Students Publications (1920)
- Manuscripts, Articles, Book Chapters and Other Papers (590)
- Open Access Publications (358)
-
- Dartmouth Scholarship (287)
- The Texas Heart Institute Journal (188)
- Children’s Nutrition Research Center Staff Publications (129)
- Articles, Abstracts, and Reports (124)
- Center for Medical Ethics and Health Policy Staff Publications (112)
- Brain and Mind Institute Researchers' Publications (94)
- Department of Medicine Faculty Papers (90)
- Peninsula Medical School (82)
- Journal Articles: Epidemiology (79)
- Faculty Publications (76)
- Pathology Research and Scholarship (76)
- Research outputs 2014 to 2021 (75)
- Paediatrics Publications (72)
- Pediatrics Faculty Publications (72)
- Department of Medical Oncology Faculty Papers (59)
- Duncan NRI Faculty and Staff Publications (58)
- Psychology Faculty Publications (58)
- School of Psychology (54)
- Theses and Dissertations (54)
- Department of Obstetrics and Gynecology Faculty Papers (53)
- Department of Surgery Faculty Papers (53)
- Department of Neurology Faculty Papers (52)
- Department of Pediatrics Faculty Papers (51)
- Faculty Research 2024 (51)
- Department of Emergency Medicine Faculty Papers (50)
- Publication Type
- File Type
Articles 11311 - 11340 of 14312
Full-Text Articles in Entire DC Network
Care Coordination For Community Transitions For Individuals Post-Stroke Returning To Low-Resource Rural Communities, Patrick H. Kitzman, Keisha Hudson, Violet Sylvia, Frances Feltner, Johnnie Lovins
Care Coordination For Community Transitions For Individuals Post-Stroke Returning To Low-Resource Rural Communities, Patrick H. Kitzman, Keisha Hudson, Violet Sylvia, Frances Feltner, Johnnie Lovins
Physical Therapy Faculty Publications
High rates of hospital readmissions have been shown within 12 months post-discharge from inpatient rehabilitation following stroke. Multiple studies coupled with our previous work indicate a need for care support for stroke survivors’ transitions to the community. The Kentucky Care Coordination for Community Transitions (KC3T) program was developed to provide access to medical, social, and environmental services to support community transitions for individuals with neurological conditions and their caregivers living in Kentucky. This program assessment was conducted to determine the effectiveness of using a specially trained community health worker to support community transitions. Thirty acute stroke survivors were …
Down Syndrome: Age-Dependence Of Pib Binding In Postmortem Frontal Cortex Across The Lifespan, Harry Levine Iii, H. Peter Spielmann, Sergey V. Matveev, Francesca Macchiavello Cauvi, M. Paul Murphy, Tina L. Beckett, Katie Mccarty, Ira T. Lott, Eric Doran, Frederick A. Schmitt, Elizabeth Head
Down Syndrome: Age-Dependence Of Pib Binding In Postmortem Frontal Cortex Across The Lifespan, Harry Levine Iii, H. Peter Spielmann, Sergey V. Matveev, Francesca Macchiavello Cauvi, M. Paul Murphy, Tina L. Beckett, Katie Mccarty, Ira T. Lott, Eric Doran, Frederick A. Schmitt, Elizabeth Head
Sanders-Brown Center on Aging Faculty Publications
Beta-amyloid (Aβ) deposition in brain accumulates as a function of age in people with Down syndrome (DS) with subsequent development into Alzheimer disease neuropathology, typically by 40 years of age. In vivo imaging using the Pittsburgh Compound B (PiB) ligand has facilitated studies linking Aβ, cognition, and dementia in DS. However, there are no studies of PiB binding across the lifespan in DS. The current study describes in vitro 3H-PiB binding in the frontal cortex of autopsy cases with DS compared to non-DS controls. Tissue from 64 cases included controls (N=25) and DS (N=39). In DS, 3H-PiB binding …
Peripheral Administration Of The Soluble Tnf Inhibitor Xpro1595 Modifies Brain Immune Cell Profiles, Decreases Beta-Amyloid Plaque Load, And Rescues Impaired Long-Term Potentiation In 5xfad Mice, Kathryn P. Macpherson, Pradoldej Sompol, George T. Kannarkat, Jianjun Chang, Lindsey Sniffen, Mary E. Wildner, Christopher M. Norris, Malú G. Tansey
Peripheral Administration Of The Soluble Tnf Inhibitor Xpro1595 Modifies Brain Immune Cell Profiles, Decreases Beta-Amyloid Plaque Load, And Rescues Impaired Long-Term Potentiation In 5xfad Mice, Kathryn P. Macpherson, Pradoldej Sompol, George T. Kannarkat, Jianjun Chang, Lindsey Sniffen, Mary E. Wildner, Christopher M. Norris, Malú G. Tansey
Sanders-Brown Center on Aging Faculty Publications
Clinical and animal model studies have implicated inflammation and peripheral immune cell responses in the pathophysiology of Alzheimer’s disease (AD). Peripheral immune cells including T cells circulate in the cerebrospinal fluid (CSF) of healthy adults and are found in the brains of AD patients and AD rodent models. Blocking entry of peripheral macrophages into the CNS was reported to increase amyloid burden in an AD mouse model. To assess inflammation in the 5xFAD (Tg) mouse model, we first quantified central and immune cell profiles in the deep cervical lymph nodes and spleen. In the brains of Tg mice, activated (MHCII …
Lisinopril Or Coreg Cr In Reducing Cardiotoxicity In Women With Breast Cancer Receiving Trastuzumab: A Rationale And Design Of A Randomized Clinical Trial, Maya Guglin, Pamela Munster, Angelina Fink, Jeffrey Krischer
Lisinopril Or Coreg Cr In Reducing Cardiotoxicity In Women With Breast Cancer Receiving Trastuzumab: A Rationale And Design Of A Randomized Clinical Trial, Maya Guglin, Pamela Munster, Angelina Fink, Jeffrey Krischer
Internal Medicine Faculty Publications
Background—Trastuzumab (TZB) is an established therapy for HER2 positive breast cancer. The use of TZB is commonly associated with cardiotoxicity manifesting as asymptomatic decrease in left ventricular ejection fraction (LVEF) or overt heart failure. Several studies demonstrated favorable effects of angiotensin converting enzyme (ACE) inhibitors and beta blockers (BB) in the prevention of chemotherapy-induced cardiotoxicity. We hypothesize that patients, randomized to receive an ACE inhibitor or a beta-blocker during trastuzumab therapy for breast cancer, will maintain a higher LVEF than patients randomized to placebo.
Methods and Results—We designed a prospective, multicenter, randomized, phase II placebo-controlled clinical trial to …
Neurophysiological Capacity In A Working Memory Task Differentiates Dependent From Nondependent Heavy Drinkers And Controls, Michael J. Wesley, Joshua A. Lile, Mark T. Fillmore, Linda J. Porrino
Neurophysiological Capacity In A Working Memory Task Differentiates Dependent From Nondependent Heavy Drinkers And Controls, Michael J. Wesley, Joshua A. Lile, Mark T. Fillmore, Linda J. Porrino
Behavioral Science Faculty Publications
Background—Determining the brain-behavior profiles that differentiate heavy drinkers who are and are not alcohol dependent will inform treatment efforts. Working memory is linked to substance use disorders and can serve as a representation of the demand placed on the neurophysiology associated with cognitive control.
Methods—Behavior and brain activity (via fMRI) were recorded during an N-Back working memory task in controls (CTRL), nondependent heavy drinkers (A-ND) and dependent heavy drinkers (A-D). Typical and novel step-wise analyses examined profiles of working memory load and increasing task demand, respectively.
Results—Performance was significantly decreased in A-D during high working memory load …
Crispr Knockout Of The Hur Gene Causes A Xenograft Lethal Phenotype., Shruti Lal, Edwin C, Cheung, Mahsa Zarei, Ranjan Preet, Saswati N. Chand, Nicole C. Mambelli-Lisboa, Carmella Romeo, Matthew C. Stout, Eric Londin, Austin Goetz, Cinthya Y. Lowder, Avinoam Nevler, Charles Yeo, Paul M. Campbell, Jordan M. Winter, Dan A. Dixon, Jonathan Brody
Crispr Knockout Of The Hur Gene Causes A Xenograft Lethal Phenotype., Shruti Lal, Edwin C, Cheung, Mahsa Zarei, Ranjan Preet, Saswati N. Chand, Nicole C. Mambelli-Lisboa, Carmella Romeo, Matthew C. Stout, Eric Londin, Austin Goetz, Cinthya Y. Lowder, Avinoam Nevler, Charles Yeo, Paul M. Campbell, Jordan M. Winter, Dan A. Dixon, Jonathan Brody
Department of Surgery Faculty Papers
Pancreatic ductal adenocarcinoma (PDA) is the third leading cause of cancer-related deaths in the United States, whereas colorectal cancer is the third most common cancer. The RNA-binding protein HuR (ELAVL1) supports a pro-oncogenic network in gastrointestinal (GI) cancer cells through enhanced HuR expression. Using a publically available database, HuR expression levels were determined to be increased in primary PDA and colorectal cancer tumor cohorts as compared with normal pancreas and colon tissues, respectively. CRISPR/Cas9 technology was successfully used to delete the HuR gene in both PDA (MIA PaCa-2 and Hs 766T) and colorectal cancer (HCT116) cell lines. HuR deficiency has …
Laboratory Analysis Of Risky Driving At 0.05% And 0.08% Blood Alcohol Concentration, Nicholas A. Van Dyke, Mark T. Fillmore
Laboratory Analysis Of Risky Driving At 0.05% And 0.08% Blood Alcohol Concentration, Nicholas A. Van Dyke, Mark T. Fillmore
Psychology Faculty Publications
Background—The public health costs associated with alcohol-related traffic crashes are a continuing problem for society. One harm reduction strategy has been to employ per se limits for blood alcohol concentrations (BACs) at which drivers can legally operate motor vehicles. This limit is currently 0.08% in all 50 US states. Recently, the National Transportation Safety Board proposed lowering the legal limit to 0.05 % (NTSB, 2013). While research has well-validated the ability of alcohol to impair driving performance and heighten crash-risk at these BACs, relatively little is known about the degree to which alcohol might increase drivers’ risk-taking.
Methods—Risk-taking …
Compulsive Buying And Quality Of Life: An Estimate Of The Monetary Cost Of Compulsive Buying Among Adults In Early Midlife, Chenshu Zhang, Judith S. Brook, Carl G. Leukefeld, Mario De La Rosa, David W. Brook
Compulsive Buying And Quality Of Life: An Estimate Of The Monetary Cost Of Compulsive Buying Among Adults In Early Midlife, Chenshu Zhang, Judith S. Brook, Carl G. Leukefeld, Mario De La Rosa, David W. Brook
Behavioral Science Faculty Publications
The aims of this study were to examine the associations between compulsive buying and quality of life and to estimate the monetary cost of compulsive buying for a cohort of men and women at mean age 43. Participants came from a community-based random sample of residents in two New York counties (N=548). The participants were followed from adolescence to early midlife. The mean age of participants at the most recent interview was 43.0 (SD=2.8). Fifty five percent of the participants were females. Over 90% of the participants were white. Linear regression analyses showed that compulsive buying was significantly associated with …
Molecular-Based Recursive Partitioning Analysis Model For Glioblastoma In The Temozolomide Era: A Correlative Analysis Based On Nrg Oncology Rtog 0525., Erica Hlavin Bell, Stephanie L Pugh, Joseph P. Mcelroy, Mark R. Gilbert, Minesh Mehta, Alexander C Klimowicz, Anthony Magliocco, Markus Bredel, Pierre Robe, Anca L. Grosu, Roger Stupp, Walter Curran, Aline P. Becker, Andrea L. Salavaggione, Jill S. Barnholtz-Sloan, Kenneth Aldape, Deborah T. Blumenthal, Paul D. Brown, Jon Glass, Luis Souhami, R. Jeffrey Lee, David Brachman, John Flickinger, Minhee Won, Arnab Chakravarti
Molecular-Based Recursive Partitioning Analysis Model For Glioblastoma In The Temozolomide Era: A Correlative Analysis Based On Nrg Oncology Rtog 0525., Erica Hlavin Bell, Stephanie L Pugh, Joseph P. Mcelroy, Mark R. Gilbert, Minesh Mehta, Alexander C Klimowicz, Anthony Magliocco, Markus Bredel, Pierre Robe, Anca L. Grosu, Roger Stupp, Walter Curran, Aline P. Becker, Andrea L. Salavaggione, Jill S. Barnholtz-Sloan, Kenneth Aldape, Deborah T. Blumenthal, Paul D. Brown, Jon Glass, Luis Souhami, R. Jeffrey Lee, David Brachman, John Flickinger, Minhee Won, Arnab Chakravarti
Department of Neurosurgery Faculty Papers
Importance: There is a need for a more refined, molecularly based classification model for glioblastoma (GBM) in the temozolomide era.
Objective: To refine the existing clinically based recursive partitioning analysis (RPA) model by incorporating molecular variables.
Design, Setting, and Participants: NRG Oncology RTOG 0525 specimens (n = 452) were analyzed for protein biomarkers representing key pathways in GBM by a quantitative molecular microscopy-based approach with semiquantitative immunohistochemical validation. Prognostic significance of each protein was examined by single-marker and multimarker Cox regression analyses. To reclassify the prognostic risk groups, significant protein biomarkers on single-marker analysis were incorporated into an RPA model …
Investigator And Independent Review Committee Exploratory Assessment And Verification Of Tumor Response In A Non-Hodgkin Lymphoma Study, Robert R Ford, Robert W Ford, Michael O'Neal, Brad S Kahl, Ling Chen, Mihaela Munteanu, Bruce D Cheson
Investigator And Independent Review Committee Exploratory Assessment And Verification Of Tumor Response In A Non-Hodgkin Lymphoma Study, Robert R Ford, Robert W Ford, Michael O'Neal, Brad S Kahl, Ling Chen, Mihaela Munteanu, Bruce D Cheson
Open Access Publications
Interpretation of endpoints (e.g. overall response rate) in clinical trials depends on the accurate and reliable measurement and identification of tumors. Regulatory agencies recommend blinded reviews of imaging data by independent review committees (IRCs). Differences in response outcomes that arise between IRCs and site investigators raise regulatory/sponsor concerns. Here, we evaluate discrepant tumor response assessments by the IRC and unblinded investigators (complete versus partial response, respectively) occurring in 52 (13% of 393 IRC-assessed responders) of 447 enrolled patients with treatment-naïve non-Hodgkin lymphoma from a randomized study. The IRC and investigators were 'likely correct' in 73% and 25% of cases, respectively …
Clara's Final Christmas Gift, Gus W Krucke
Clara's Final Christmas Gift, Gus W Krucke
Faculty, Staff and Student Publications
No abstract provided.
White Blood Cell Subtypes Are Associated With A Greater Long-Term Risk Of Death After Acute Myocardial Infarction, Arthur Shiyovich, Harel Gilutz, Ygal Plakht
White Blood Cell Subtypes Are Associated With A Greater Long-Term Risk Of Death After Acute Myocardial Infarction, Arthur Shiyovich, Harel Gilutz, Ygal Plakht
The Texas Heart Institute Journal
We evaluated the association between white blood cell counts and long-term mortality rates in 2,129 patients (mean age, 65.3 ± 13.5 yr; 69% men) who had survived acute myocardial infarction. We obtained white blood cell counts and differential counts of white blood cell subtypes within the first 72 hours of hospital admission. The primary outcome was all-cause death at 1, 5, and 10 years after acute myocardial infarction.
In regard to death in the long term, we found significant negative linear associations (lymphocytes), positive linear associations (neutrophils and the neutrophil-to-lymphocyte ratio), and nonlinear U-shaped associations (basophils, eosinophils, monocytes, and total …
Expanding The Genotypic Spectrum Of Bathing Suit Ichthyosis., Nareh V. Marukian, Rong-Hua Hu, Brittany G. Craiglow, Leonard M. Milstone, Jing Zhou, Amy Theos, Hande Kaymakcalan, Deniz A. Akkaya, Jouni J. Uitto, Hassan Vahidnezhad, Leila Youssefian, Susan J. Bayliss, Amy S. Paller, Lynn M. Boyden, Keith A. Choate
Expanding The Genotypic Spectrum Of Bathing Suit Ichthyosis., Nareh V. Marukian, Rong-Hua Hu, Brittany G. Craiglow, Leonard M. Milstone, Jing Zhou, Amy Theos, Hande Kaymakcalan, Deniz A. Akkaya, Jouni J. Uitto, Hassan Vahidnezhad, Leila Youssefian, Susan J. Bayliss, Amy S. Paller, Lynn M. Boyden, Keith A. Choate
Department of Dermatology and Cutaneous Biology Faculty Papers
Importance: Bathing suit ichthyosis (BSI) is a rare congenital disorder of keratinization characterized by restriction of scale to sites of relatively higher temperature such as the trunk, with cooler areas remaining unaffected. Fewer than 40 cases have been reported in the literature. Bathing suit ichthyosis is caused by recessive, temperature-sensitive mutations in the transglutaminase-1 gene (TGM1). Clear genotype-phenotype correlations have been difficult to establish because several of the same TGM1 mutations have been reported in BSI and other forms of congenital ichthyosis. We identify novel and recurrent mutations in 16 participants with BSI.
Objective: To expand the genotypic spectrum of …
Evaluation Of Chest Pain After Implantable Cardioverter-Defibrillator Placement, Amir Gahremanpour, Mohammad Saeed, Yochai Birnbaum
Evaluation Of Chest Pain After Implantable Cardioverter-Defibrillator Placement, Amir Gahremanpour, Mohammad Saeed, Yochai Birnbaum
The Texas Heart Institute Journal
No abstract provided.
Transcatheter Tricuspid Valve-In-Valve Replacement With An Edwards Sapien 3 Valve, Pranav Loyalka, Angelo Nascimbene, Benjamin Metz, Igor D Gregoric, Ajay Sundara Raman, Biswajit Kar
Transcatheter Tricuspid Valve-In-Valve Replacement With An Edwards Sapien 3 Valve, Pranav Loyalka, Angelo Nascimbene, Benjamin Metz, Igor D Gregoric, Ajay Sundara Raman, Biswajit Kar
The Texas Heart Institute Journal
A few case reports and case series have documented the outcomes in patients with tricuspid bioprosthetic valvular degeneration who underwent transcatheter implantation of the Medtronic Melody and the Edwards Sapien XT and Sapien 3 valves. In this report, we describe the case of a 49-year-old woman with severe bioprosthetic tricuspid valvular stenosis and multiple comorbidities who underwent transcatheter tricuspid valve replacement with a Sapien 3 valve.
Incremental Validity Of The Pid-5 In Relation To The Five Factor Model And Traditional Polythetic Personality Criteria Of The Dsm-5, J Christopher Fowler, Michelle A Patriquin, Alok Madan, Jon G Allen, B Christopher Frueh, John M Oldham
Incremental Validity Of The Pid-5 In Relation To The Five Factor Model And Traditional Polythetic Personality Criteria Of The Dsm-5, J Christopher Fowler, Michelle A Patriquin, Alok Madan, Jon G Allen, B Christopher Frueh, John M Oldham
Staff and Researcher Publications
Background: This study assessed the incremental validity of the Personality Inventory for DSM-5 (PID-5) beyond the impact of demographic, burden of illness, five-factor model of personality, and DSM-5 personality disorder criteria with respect to associations with admission psychiatric symptoms and functional disability.
Methods: Psychiatric inpatients (N = 927) were administered the Big Five Inventory, PID-5, and personality disorder criteria counts. Prior treatment utilization, as well as baseline depression, anxiety, emotion regulation, and functional disability were administered within two days of the personality measures. Hierarchical regression models were used to explore the association of personality functioning with symptom functioning, emotion regulation …
Combination Epigenetic Therapy In Metastatic Colorectal Cancer (Mcrc) With Subcutaneous 5-Azacitidine And Entinostat: A Phase 2 Consortium/Stand Up 2 Cancer Study, Nilofer S. Azad, Douglas Adkins, Joel Picus, Richard Piekarz, Et Al
Combination Epigenetic Therapy In Metastatic Colorectal Cancer (Mcrc) With Subcutaneous 5-Azacitidine And Entinostat: A Phase 2 Consortium/Stand Up 2 Cancer Study, Nilofer S. Azad, Douglas Adkins, Joel Picus, Richard Piekarz, Et Al
Open Access Publications
PURPOSE: Therapy with demethylating agent 5-azacitidine and histone deacetylase inhibitor entinostat shows synergistic re-expression of tumor-suppressor genes and growth inhibition in colorectal (CRC) cell lines and in vivo studies.
EXPERIMENTAL DESIGN: We conducted a phase II, multi-institutional study of the combination in metastatic CRC patients. Subcutaneous azacitidine was administered at 40 mg/m2 days 1-5 and 8-10 and entinostat was given 7 mg orally on days 3 and 10. An interim analysis indicated toxicity crossed the pre-specified safety boundary but was secondary to disease. A 2nd cohort with added eligibility restrictions was accrued: prior therapies were limited to no more than …
Bi-Lateral Compartment Syndrome In Feet And Gastrocnemius-Soleus Complex Of A High School Female Soccer And Lacrosse Player, Cassandra Parise, Jeffery Huston
Bi-Lateral Compartment Syndrome In Feet And Gastrocnemius-Soleus Complex Of A High School Female Soccer And Lacrosse Player, Cassandra Parise, Jeffery Huston
Journal of Sports Medicine and Allied Health Sciences: Official Journal of the Ohio Athletic Trainers Association
In Volume 3, Issue 1 of the JSMAHS you will find Professional research abstracts, as well as Under Graduate student research abstracts, case reports, and critically appraised topics.
Thank you for viewing this 3rd Annual OATA Special Edition.
Serious Mental Illness Among Young Adult Women Who Use Drugs In The Club Scene: Co-Occurring Biopsychosocial Factors, Maayan Lawental, Hilary L. Surratt, Mance E. Buttram, Steven P. Kurtz
Serious Mental Illness Among Young Adult Women Who Use Drugs In The Club Scene: Co-Occurring Biopsychosocial Factors, Maayan Lawental, Hilary L. Surratt, Mance E. Buttram, Steven P. Kurtz
Center for Health Services Research Faculty Publications
Young women who regularly attend nightclubs are at risk for numerous health and social consequences, including mental distress, sexual and physical victimization and substance dependence. This paper uses a biopsychosocial framework to examine co-occurring mental health problems, victimization, substance dependence, sexual risk and physical pain among a sample of young women who use drugs (N = 222) in Miami’s club scene. The majority of women were under 24 years old, Hispanic, and identified as heterosexual. Almost all the women reported past 90-day use of alcohol, ecstasy/MDMA, marijuana, cocaine and prescription opioids and benzodiazepines; 32% of women reported being in a …
The Effects Of Nicotine In The Neonatal Quinpirole Rodent Model Of Psychosis: Neural Plasticity Mechanisms And Nicotinic Receptor Changes, Daniel J. Peterson, W. Drew Gill, John M. Dose, Donald B. Hoover, James R. Pauly, Elizabeth D. Cummins, Katherine C. Burgess, Russell W. Brown
The Effects Of Nicotine In The Neonatal Quinpirole Rodent Model Of Psychosis: Neural Plasticity Mechanisms And Nicotinic Receptor Changes, Daniel J. Peterson, W. Drew Gill, John M. Dose, Donald B. Hoover, James R. Pauly, Elizabeth D. Cummins, Katherine C. Burgess, Russell W. Brown
Pharmaceutical Sciences Faculty Publications
Neonatal quinpirole (NQ) treatment to rats increases dopamine D2 receptor sensitivity persistent throughout the animal’s lifetime. In Experiment 1, we analyzed the role of α7 and α4β2 nicotinic receptors (nAChRs) in nicotine behavioral sensitization and on the brain-derived neurotrophic factor (BDNF) response to nicotine in NQ- and neonatally saline (NS)-treated rats. In Experiment 2, we analyzed changes in α7 and α4β2 nAChR density in the nucleus accumbens (NAcc) and dorsal striatum in NQ and NS animals sensitized to nicotine. Male and female Sprague-Dawley rats were neonatally treated with quinpirole (1 mg/kg) or saline from postnatal days (P)1–21. Animals were given …
A Narrative Study On The Leadership Development Of Female Superintendents In New Jersey, Mitzi N. Morillo
A Narrative Study On The Leadership Development Of Female Superintendents In New Jersey, Mitzi N. Morillo
Seton Hall University Dissertations and Theses (ETDs)
The purpose of this study was to explore, through the lived experiences of 8 women who achieved the superintendency in New Jersey, the intersectionality of gender, social norms, and race and how these women developed as leaders. The study was designed to identify perceived barriers to career ascension in education administration and the successful strategies that female superintendents in New Jersey utilized to overcome those barriers. The study explored strategies that future leaders might utilize to address leadership development and career ascendency for women who aspire to the superintendency. For this study, a narrative research design was best suited to …
Single-Trait And Multi-Trait Genome-Wide Association Analyses Identify Novel Loci For Blood Pressure In African-Ancestry Populations, Jingjing Liang, Thu H. Le, Digna R. Velez Edwards, Bamidele O. Tayo, Kyle J. Gaulton, Jennifer A. Smith, Yingchang Lu, Richard A. Jensen, Guanjie Chen, Lisa R. Yanek, Karen Schwander, Salman M. Tajuddin, Tamar Sofer, Wonji Kim, James Kayima, Colin A. Mckenzie, Ervin Fox, Michael A. Nalls, J. Hunter Young, Yan V. Sun, Jacqueline M. Lane, Sylvia Cechova, Jie Zhou, Hua Tang, Myriam Fornage, Solomon K. Musani, Heming Wang, Juyoung Lee, Adebowale Adeyemo, Albert W. Dreisbach, Donna K. Arnett
Single-Trait And Multi-Trait Genome-Wide Association Analyses Identify Novel Loci For Blood Pressure In African-Ancestry Populations, Jingjing Liang, Thu H. Le, Digna R. Velez Edwards, Bamidele O. Tayo, Kyle J. Gaulton, Jennifer A. Smith, Yingchang Lu, Richard A. Jensen, Guanjie Chen, Lisa R. Yanek, Karen Schwander, Salman M. Tajuddin, Tamar Sofer, Wonji Kim, James Kayima, Colin A. Mckenzie, Ervin Fox, Michael A. Nalls, J. Hunter Young, Yan V. Sun, Jacqueline M. Lane, Sylvia Cechova, Jie Zhou, Hua Tang, Myriam Fornage, Solomon K. Musani, Heming Wang, Juyoung Lee, Adebowale Adeyemo, Albert W. Dreisbach, Donna K. Arnett
Epidemiology and Environmental Health Faculty Publications
Hypertension is a leading cause of global disease, mortality, and disability. While individuals of African descent suffer a disproportionate burden of hypertension and its complications, they have been underrepresented in genetic studies. To identify novel susceptibility loci for blood pressure and hypertension in people of African ancestry, we performed both single and multiple-trait genome-wide association analyses. We analyzed 21 genome-wide association studies comprised of 31,968 individuals of African ancestry, and validated our results with additional 54,395 individuals from multi-ethnic studies. These analyses identified nine loci with eleven independent variants which reached genome-wide significance (P < 1.25×10−8) for either systolic and …
Impact Of Ibrutinib Dose Adherence On Therapeutic Efficacy In Patients With Previously Treated Cll/Sll., Paul M Barr, Jennifer R Brown, Peter Hillmen, Susan O'Brien, Jacqueline C Barrientos, Nishitha M Reddy, Steven Coutre, Stephen P Mulligan, Ulrich Jaeger, Richard R Furman, Florence Cymbalista, Marco Montillo, Claire Dearden, Tadeusz Robak, Carol Moreno, John M Pagel, Jan A Burger, Samuel Suzuki, Juthamas Sukbuntherng, George Cole, Danelle F James, John C Byrd
Impact Of Ibrutinib Dose Adherence On Therapeutic Efficacy In Patients With Previously Treated Cll/Sll., Paul M Barr, Jennifer R Brown, Peter Hillmen, Susan O'Brien, Jacqueline C Barrientos, Nishitha M Reddy, Steven Coutre, Stephen P Mulligan, Ulrich Jaeger, Richard R Furman, Florence Cymbalista, Marco Montillo, Claire Dearden, Tadeusz Robak, Carol Moreno, John M Pagel, Jan A Burger, Samuel Suzuki, Juthamas Sukbuntherng, George Cole, Danelle F James, John C Byrd
Articles, Abstracts, and Reports
Ibrutinib, an oral inhibitor of Bruton's tyrosine kinase (BTK), at a once-daily dose of 420 mg achieved BTK active-site occupancy in patients with chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL) that was maintained at 24 hours. It is unknown if intermittent interruption of ibrutinib therapy contributes to altered clinical outcomes. We therefore evaluated the effect of ibrutinib dose adherence on patient outcomes in the phase 3 RESONATE trial. The overall mean dose intensity (DI) was 95% with median treatment duration of ∼9 months. Pharmacokinetic assessment of ibrutinib exposure at 420-mg dose suggested similar exposure regardless of patient weight or age. …
A Serosurvey Of Selected Cystogenic Coccidia In Spanish Equids: First Detection Of Anti-Besnoitia Spp. Specific Antibodies In Europe, Daniel Gutiérrez-Expósito, Ignacio García-Bocanegra, Daniel K. Howe, Antonio Arenas-Montes, Michelle R. Yeargan, Sallyanne L. Ness, Luis M Ortega-Mora, G. Álvarez-García
A Serosurvey Of Selected Cystogenic Coccidia In Spanish Equids: First Detection Of Anti-Besnoitia Spp. Specific Antibodies In Europe, Daniel Gutiérrez-Expósito, Ignacio García-Bocanegra, Daniel K. Howe, Antonio Arenas-Montes, Michelle R. Yeargan, Sallyanne L. Ness, Luis M Ortega-Mora, G. Álvarez-García
Veterinary Science Faculty Publications
Background: Equine besnoitiosis, caused by Besnoitia bennetti, and equine protozoal myeloencephalitis (EPM), caused by Sarcocystis neurona and Neospora hughesi are relevant equine diseases in the Americas that have been scarcely studied in Europe. Thus, a serosurvey of these cystogenic coccidia was carried out in Southern Spain. A cross-sectional study was performed and serum samples from horses (n = 553), donkeys (n = 85) and mules (n = 83) were included. An in-house enzyme-linked immunosorbent assay (ELISA) was employed to identify a Besnoitia spp. infection and positive results were confirmed by an a posteriori western blot. For Neospora …
Impact Of Sublethal Exposure To A Pyrethroid-Neonicotinoid Insecticide On Mating, Fecundity And Development In The Bed Bug Cimex Lectularius L. (Hemiptera: Cimicidae), Sydney E. Crawley, Jennifer R. Gordon, Katelyn A. Kowles, Michael F. Potter, Kenneth F. Haynes
Impact Of Sublethal Exposure To A Pyrethroid-Neonicotinoid Insecticide On Mating, Fecundity And Development In The Bed Bug Cimex Lectularius L. (Hemiptera: Cimicidae), Sydney E. Crawley, Jennifer R. Gordon, Katelyn A. Kowles, Michael F. Potter, Kenneth F. Haynes
Entomology Faculty Publications
Sublethal exposure to an insecticide may alter insect feeding, mating, oviposition, fecundity, development, and many other life history parameters. Such effects may have population-level consequences that are not apparent in traditional dose-mortality evaluations. Earlier, we found that a routinely used combination insecticide that includes a pyrethroid and a neonicotinoid (Temprid® SC) had deleterious effects on multiple bed bug (Cimex lectularius, L.) behaviors. Here, we demonstrate that sublethal exposure impacts physiology and reproduction as well. We report that sublethal exposure to Temprid SC has variable aberrant effects on bed bugs depending on the strain, including: a reduction in …
Latin American Gender Politics: Examining The Relationship Between Gender And Political Participation, Haley B. Lawrie
Latin American Gender Politics: Examining The Relationship Between Gender And Political Participation, Haley B. Lawrie
Senior Honors Projects, 2010-2019
Political participation highlights a great deal about the political system in a given country and how the system responds in turn. Women have a distinct way of participating in politics, particularly in the culture of machismo in contemporary Latin America. In this thesis, I examine the relationship between gender and political participation within two Latin American countries, Peru and Argentina. Through an analysis of voter turnout, political interest, cabinet participation, and political movements, I examine how gender impacts the political sphere. I ultimately argue that gender by itself is not distinctly tied to levels of participatory action for the average …
Running Comes Before Winning: Explaining The Gender Differential In State Legislatures, Marissa Piccolo
Running Comes Before Winning: Explaining The Gender Differential In State Legislatures, Marissa Piccolo
Honors Scholar Theses
What factors influence the likelihood that a woman runs for, wins, and holds political office across the country? Is it easier to explain why a woman runs in, than that she ultimately represents, a certain district? I compare a series of state-level and district-level independent variables and relate them to two different dependent variables: that a woman ran for a district seat, and that a woman represents a district. I explore what, and how much, political geography and contextual factors can explain. My preliminary findings show that it is easier to explain the probability that a woman runs, than that …
The Effect Of Menstrual Phase And Oral Contraceptive Steroids On Caffeine During Cycling Performance, Annette M. Lemanski
The Effect Of Menstrual Phase And Oral Contraceptive Steroids On Caffeine During Cycling Performance, Annette M. Lemanski
Masters Theses, 2010-2019
PURPOSE: There is evidence that female sex hormones impact caffeine metabolism, with decreased CYP1A2 activity and diminished caffeine clearance in women with higher estrogen levels. Therefore, the objectives of this project were to determine the effects of oral contraceptives and menstrual cycle on the benefits of caffeine supplementation for cycling performance. METHODS: Sixteen recreationally trained female cyclists, oral contraceptive steroid (OCS) users (n=8, age = 21.4 ± 1.4 years, height = 168.4 ± 3.6 cm, weight = 63.6 ± 7.2kg, VO2max = 48.0 ± 4.0 ml/kg/min), and non-users (n=8, age = 20.9 ± 2.1 years, height = 161.0 ± …
The Role Of Refugee Women Narratives In The U.S. Resettlement Process, Alys N. Sink
The Role Of Refugee Women Narratives In The U.S. Resettlement Process, Alys N. Sink
Masters Theses, 2010-2019
Within resettlement scholarship, there exists a distinct absence of direct narratives by refugee women about their resettlement experiences within the United States. This absence of voice has even been noted by refugee women representatives during a 2013 UNHCR dialogue stating that: “We call for a model in which the State, the municipalities, NGOs and refugees work together to learn from each other, hear the voices from the grassroots and together develop comprehensive, coordinated and long-term responses” (Speaking for Ourselves: Hearing Refugee Voices, A Journey Towards Empowerment). This study delves into this absence of voice locally, investigating the ways in which …
Middle Ear Mass Causing Vertigo And Facial Nerve Weakness, Aron Kandinov, Matthew Smith, Syed F. Ahsan
Middle Ear Mass Causing Vertigo And Facial Nerve Weakness, Aron Kandinov, Matthew Smith, Syed F. Ahsan
Otolaryngology Articles
No abstract provided.