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Articles 3871 - 3900 of 4831
Full-Text Articles in Entire DC Network
Allergic Diseases And Internalizing Behaviors In Early Childhood., Maya K. Nanda, Grace K. Lemasters, Linda Levin, Marc E. Rothenberg, Amal H. Assa'ad, Nicholas Newman, David Bernstein, Gurjit Khurana-Hershey, James E. Lockey, Patrick H. Ryan
Allergic Diseases And Internalizing Behaviors In Early Childhood., Maya K. Nanda, Grace K. Lemasters, Linda Levin, Marc E. Rothenberg, Amal H. Assa'ad, Nicholas Newman, David Bernstein, Gurjit Khurana-Hershey, James E. Lockey, Patrick H. Ryan
Manuscripts, Articles, Book Chapters and Other Papers
BACKGROUND AND OBJECTIVES: The relationship between allergic diseases and internalizing disorders has not been well characterized with regard to multiple allergic diseases or longitudinal study. The objective of this study was to examine the association between multiple allergic diseases in early childhood with validated measures of internalizing disorders in the school-age years.
METHODS: Children enrolled in the Cincinnati Childhood Allergy and Air Pollution Study underwent skin testing and examinations at ages 1, 2, 3, 4, and 7 years. At age 7, parents completed the Behavior Assessment System for Children, Second Edition (BASC-2), a validated measure of childhood behavior and emotion. …
Dog Walking Among Adolescents: Correlates And Contribution To Physical Activity., Jessa K. Engelberg, Jordan A. Carlson, Terry L. Conway, Kelli L. Cain, Brian E. Saelens, Karen Glanz, Lawrence D. Frank, James F. Sallis
Dog Walking Among Adolescents: Correlates And Contribution To Physical Activity., Jessa K. Engelberg, Jordan A. Carlson, Terry L. Conway, Kelli L. Cain, Brian E. Saelens, Karen Glanz, Lawrence D. Frank, James F. Sallis
Manuscripts, Articles, Book Chapters and Other Papers
PURPOSE: To assess the association of dog walking with adolescents' moderate-to-vigorous physical activity (MVPA) and body mass index (BMI), and identify correlates of dog walking.
METHODS/DESIGN: Participants were 12-17year-olds (n=925) from the Baltimore, MD and Seattle, WA regions. Differences in accelerometer-assessed minutes/day of MVPA and self-reported BMI (percentile) were compared among adolescents (1) without a dog (n=441) and those with a dog who (2) did (≥1days/week, n=300) or (3) did not (n=184) walk it. Correlates of (1) dog walking (any vs. none) among adolescents with dogs (n=484), and (2) days/week of dog walking among dog walkers (n=300) were investigated. Potential …
Women's Professional Sports: A Case Study On Practices That Could Increase Their Profitability, Danielle H. Mcardle
Women's Professional Sports: A Case Study On Practices That Could Increase Their Profitability, Danielle H. Mcardle
Honors Undergraduate Theses
Women’s professional sports leagues have often been considered a risky business endeavor. Critics cite low attendance, lack of sponsorships, lack of media rights deals, and numerous other reasons for why women’s professional sports leagues are not profitable. In analyzing the current landscape of women’s professional sport leagues, this paper uses a case study approach to develop a strategy that will highlight lessons learned from past women’s professional sports leagues, current professional sports leagues, sponsorship agreements, fans, social, digital, and mobile marketing strategies, and management practices to show how the business of women’s sports could be made into a more profitable …
Neighborhood-Level Poverty At Menarche And Prepregnancy Obesity In African-American Women, Andrea E. Cassidy-Bushrow, Rosalind M. Peters, Charlotte Burmeister, Lawrence F. Bielak, Dayna A. Johnson
Neighborhood-Level Poverty At Menarche And Prepregnancy Obesity In African-American Women, Andrea E. Cassidy-Bushrow, Rosalind M. Peters, Charlotte Burmeister, Lawrence F. Bielak, Dayna A. Johnson
Public Health Sciences Articles
Introduction: Menarche is a critical time point in a woman's reproductive system development; exposures at menarche may influence maternal health. Living in a poorer neighborhood is associated with adult obesity; however, little is known if neighborhood factors at menarche are associated with prepregnancy obesity.
Methods: We examined the association of neighborhood-level poverty at menarche with prepregnancy body mass index category in 144 pregnant African-American women. Address at menarche was geocoded to census tract (closest to year of menarche); neighborhood-level poverty was defined as the proportion of residents living under the federal poverty level. Cumulative logistic regression was used to examine …
Placental Epigenetics In Children’S Environmental Health, Carmen Marsit
Placental Epigenetics In Children’S Environmental Health, Carmen Marsit
Dartmouth Scholarship
There is a growing interest in understanding the mechanisms that drive the developmental origins of health and disease, and the role of epigenetic regulation has risen to the forefront of these studies. In particular, the placenta may be a model organ to consider as a mediator of the impact of the environment on developmental programming of children's health, as this organ plays a critical role in directing development and regulating the fetal environment. Several recent studies have begun to examine how environmental toxicant exposures can impact the placental epigenome, focusing on studies of DNA methylation and microRNA expression. This review …
Regional Implementation Of A Pediatric Cardiology Syncope Algorithm Using Standardized Clinical Assessment And Management Plans (Scamps) Methodology, Yvonne Paris, Olga H. Toro‐Salazar, Naomi S. Gauthier, Kathleen Rotondo, Lucy Arnold, Rose Hamershock, David E. Saudek, David R. Fulton, Ashley Renaud, Mark E. Alexander, New England Congenital Cardiology Association (Necca
Regional Implementation Of A Pediatric Cardiology Syncope Algorithm Using Standardized Clinical Assessment And Management Plans (Scamps) Methodology, Yvonne Paris, Olga H. Toro‐Salazar, Naomi S. Gauthier, Kathleen Rotondo, Lucy Arnold, Rose Hamershock, David E. Saudek, David R. Fulton, Ashley Renaud, Mark E. Alexander, New England Congenital Cardiology Association (Necca
Dartmouth Scholarship
Background:
Pediatric syncope is common. Cardiac causes are rarely found. We describe and assess a pragmatic approach to these patients first seen by a pediatric cardiologist in the New England region, using Standardized Clinical Assessment and Management Plans (SCAMPs).
Methods and Results:
Ambulatory patients aged 7 to 21 years initially seen for syncope at participating New England Congenital Cardiology Association practices over a 2.5‐year period were evaluated using a SCAMP. Findings were iteratively analyzed and the care pathway was revised. The vast majority (85%) of the 1254 patients had typical syncope. A minority had exercise‐related or more problematic symptoms. Guideline‐defined …
The Relationship Between “Feeling Fat” And Weight-Gain Feedback In A Non-Eating-Disordered Female Sample: Clinical Perfectionism As A Related Variable, Jenna Dilossi
PCOM Psychology Dissertations
This study investigated the relationship between feeling fat and weight-gain feedback in a sample of 111 non-eating-disordered women between the ages of 18 to 45 years. Specifically, this study examined feeling fat with regard to feedback type (i.e., weight reading or clothing size) and social context (i.e., alone or with peers present). Additionally, perfectionism was examined as a related variable within this relationship. Hypotheses related to social context and perfectionism were supported, whereas hypotheses related to feedback type were not supported. Results indicated a significant main effect for social context on feeling fat scores and an insignificant interaction effect for …
The Impact Of Internet Social Networking On Young Women’S Mood And Body Image Satisfaction: An Experimental Design, Tara Scirrotto Drames
The Impact Of Internet Social Networking On Young Women’S Mood And Body Image Satisfaction: An Experimental Design, Tara Scirrotto Drames
PCOM Psychology Dissertations
In the present study, the impact of viewing various types of female images online was examined to approximate the potential impact of online photo viewing on social-networking sites. Two-hundred forty-one young women between the ages of 18 and 30 years were recruited on social-networking sites to participate. In this randomized-controlled, Internet-based study, participants were randomly assigned to one of the following groups of roughly 50 participants each: (a) very attractive-thin, (b) very attractive-not thin, (c) average-attractive-thin, (d) average attractive-not thin, and (c) control (landscapes). All participants viewed the corresponding images online via a “mock” social networking page created by the …
Cognitive Distortions: Predictors Of Medical Adherence And Health Behaviors Among Women At Risk For Breast Cancer, Amanda Viner
Cognitive Distortions: Predictors Of Medical Adherence And Health Behaviors Among Women At Risk For Breast Cancer, Amanda Viner
PCOM Psychology Dissertations
This study examined the relationship between cognitive distortions and health behaviors among women at risk for breast cancer. Sixty-eight participants completed an online survey consisting of demographic information, the Inventory of Cognitive Distortions (ICD), and the Health Adherence Behavior Inventory (HABIT). Results of the study indicate that health behaviors decrease as thinking becomes more distorted. The data also suggest that various cognitive distortions predict worse adherence, including fortune telling, minimization, and magnification. These findings have implications for the role of clinical psychologists in healthcare settings, and for the utility and implementation of cognitive behavioral interventions to increase early detection and …
Effect Of Tiotropium On Night-Time Awakening And Daily Rescue Medication Use In Patients With Copd, Peter M.A. Calverley, Stephen I. Rennard, Emmanuelle Clerisme-Beaty, Norbert Metzdorf, Valentina Bayer Zubek, Richard Zuwallack
Effect Of Tiotropium On Night-Time Awakening And Daily Rescue Medication Use In Patients With Copd, Peter M.A. Calverley, Stephen I. Rennard, Emmanuelle Clerisme-Beaty, Norbert Metzdorf, Valentina Bayer Zubek, Richard Zuwallack
Journal Articles: Pulmonary & Critical Care Med
BACKGROUND: Several small studies found night-time awakenings due to COPD symptoms were associated with decreased health status. In this study, night-time awakenings in patients with COPD were examined and effects of tiotropium therapy evaluated.
METHODS: This study was a post hoc, exploratory, pooled analysis of twin, multicenter, double-blind, randomized, placebo-controlled, parallel-group trials. Patients with stable moderate-to-severe COPD were randomized to tiotropium HandiHaler® (n = 550) or placebo (n = 371) and followed for 13 weeks. During a 2-week, pre-treatment baseline period and for 13 weeks on treatment, self-reported night-time awakenings due to COPD symptoms, rescue medication (albuterol) use, and morning …
Contextualizing Multilayered Sexual Subjectivities Of Heterosexual Black Female Undergraduate Students At A Predominantly White Institution In The South, Amarachi Rossana Anakaraonye
Contextualizing Multilayered Sexual Subjectivities Of Heterosexual Black Female Undergraduate Students At A Predominantly White Institution In The South, Amarachi Rossana Anakaraonye
Theses and Dissertations
This study uses an intersectional theoretical framework to examine Black college women’s sexual health by focusing on how they engage in sexual decision making within their social contexts. This qualitative study analyzed 20 individual in-depth interviews of Black female undergraduate students, ages 18-22, who attend a predominantly white institution (PWI) in the Southeastern United States. The themes that emerged from qualitative data analysis include Black female undergraduate students’ perceptions of the sexual culture of their campus and the protective strategies they employ to navigate the sexual culture in order to achieve and/or maintain physical, emotional, and social well-being. Key findings …
Early Adverse Experiences And Health: The Transition To College, Kelly B. Filipkowski, Kristin E. Heron, Joshua M. Smyth
Early Adverse Experiences And Health: The Transition To College, Kelly B. Filipkowski, Kristin E. Heron, Joshua M. Smyth
Psychology Faculty Publications
Objective: This study cross-sectionally and prospectively examined the impact of adversity experienced prior to college on the health and well-being of students adjusting to their first college semester. Methods: Two-hundred sixteen (216) first-year students completed measures of adverse life experiences, perceived stress, physical symptoms, and health-related behaviors during the first 2 weeks of college entry and again at the end of the first semester. Results: Reported adversity prior to college predicted greater perceived stress and physical symptoms at college entry and an increase in physical symptoms over the semester; perceived stress mediated the prospective changes. Early adversity …
Effective Combat Leadership: How Do Individual, Social, And Organizational Factors In The U.S. Army Reserve Cultivate Effective Women's Leadership In Dangerous Contexts?, Diana Drita Ellerman
Effective Combat Leadership: How Do Individual, Social, And Organizational Factors In The U.S. Army Reserve Cultivate Effective Women's Leadership In Dangerous Contexts?, Diana Drita Ellerman
Antioch University Dissertations & Theses
This research centered on the experiences of a dozen women who served in U.S. Army Reserve leadership positions. Although they served in dangerous contexts the Army had an exclusionary policy at the time that formally excluded the women from direct combat. The impetus for the research was Secretary of Defense Leon Panetta's announcement in January 2013 that the U.S. military would be eliminating the exclusionary policy. The purpose of this study was to gain insight into what individual, social, and organizational factors support women's effective leadership in dangerous contexts. The research utilized narrative inquiry in order to bring forth the …
Please Do Whatever It Takes To End Our Daughter's Suffering!, Stéphan Clément De Cléty, Marie Friedel, A A Eduard Verhagen, John D. Lantos, Brian S. Carter
Please Do Whatever It Takes To End Our Daughter's Suffering!, Stéphan Clément De Cléty, Marie Friedel, A A Eduard Verhagen, John D. Lantos, Brian S. Carter
Manuscripts, Articles, Book Chapters and Other Papers
What is the best way to care for a child with severe neurologic impairment who seems to be dying and is in intractable pain? Can we give sedation as we remove life support? Is it ethically permissible to hasten death? In the United States, 5 states have legalized assisted suicide (although only for competent adults). In Belgium and the Netherlands, euthanasia is legal for children under some circumstances. We present a case in which parents and doctors face difficult decisions about palliative care. Experts from Belgium, the Netherlands, and the United States then discuss how they would respond to such …
Locations Of Physical Activity As Assessed By Gps In Young Adolescents., Jordan A. Carlson, Jasper Schipperijn, Jacqueline Kerr, Brian E. Saelens, Loki Natarajan, Lawrence D. Frank, Karen Glanz, Terry L. Conway, Kelli L. Cain, James F. Sallis, J E. Chapman
Locations Of Physical Activity As Assessed By Gps In Young Adolescents., Jordan A. Carlson, Jasper Schipperijn, Jacqueline Kerr, Brian E. Saelens, Loki Natarajan, Lawrence D. Frank, Karen Glanz, Terry L. Conway, Kelli L. Cain, James F. Sallis, J E. Chapman
Manuscripts, Articles, Book Chapters and Other Papers
OBJECTIVES: To compare adolescents' physical activity at home, near home, at school, near school, and at other locations.
METHODS: Adolescents (N = 549) were ages 12 to 16 years (49.9% girls, 31.3% nonwhite or Hispanic) from 447 census block groups in 2 US regions. Accelerometers and Global Positioning System devices assessed minutes of and proportion of time spent in moderate to vigorous physical activity (MVPA) in each of the 5 locations. Mixed-effects regression compared MVPA across locations and demographic factors.
RESULTS: Forty-two percent of adolescents' overall MVPA occurred at school, 18.7% at home, 18.3% in other (nonhome, nonschool) locations, and …
Two-Arm Randomized Pilot Intervention Trial To Decrease Sitting Time And Increase Sit-To-Stand Transitions In Working And Non-Working Older Adults., Jacqueline Kerr, Michelle Takemoto, Khalisa Bolling, Andrew Atkin, Jordan A. Carlson, Dori Rosenberg, Katie Crist, Suneeta Godbole, Brittany Lewars, Claudia Pena, Gina Merchant
Two-Arm Randomized Pilot Intervention Trial To Decrease Sitting Time And Increase Sit-To-Stand Transitions In Working And Non-Working Older Adults., Jacqueline Kerr, Michelle Takemoto, Khalisa Bolling, Andrew Atkin, Jordan A. Carlson, Dori Rosenberg, Katie Crist, Suneeta Godbole, Brittany Lewars, Claudia Pena, Gina Merchant
Manuscripts, Articles, Book Chapters and Other Papers
BACKGROUND: Excessive sitting has been linked to poor health. It is unknown whether reducing total sitting time or increasing brief sit-to-stand transitions is more beneficial. We conducted a randomized pilot study to assess whether it is feasible for working and non-working older adults to reduce these two different behavioral targets.
METHODS: Thirty adults (15 workers and 15 non-workers) age 50-70 years were randomized to one of two conditions (a 2-hour reduction in daily sitting or accumulating 30 additional brief sit-to-stand transitions per day). Sitting time, standing time, sit-to-stand transitions and stepping were assessed by a thigh worn inclinometer (activPAL). Participants …
Depressive Symptoms In Children With Chronic Kidney Disease., Amy J. Kogon, Matthew B. Matheson, Joseph T. Flynn, Arlene C. Gerson, Bradley A. Warady, Susan L. Furth, Stephen R. Hooper, Chronic Kidney Disease In Children (Ckid) Study Group
Depressive Symptoms In Children With Chronic Kidney Disease., Amy J. Kogon, Matthew B. Matheson, Joseph T. Flynn, Arlene C. Gerson, Bradley A. Warady, Susan L. Furth, Stephen R. Hooper, Chronic Kidney Disease In Children (Ckid) Study Group
Manuscripts, Articles, Book Chapters and Other Papers
OBJECTIVE: To assess depression in children with chronic kidney disease and to determine associations with patient characteristics, intellectual and educational levels, and health-related quality of life (HRQoL).
STUDY DESIGN: Subjects aged 6-17 years from the Chronic Kidney Disease in Children cohort study completed the Children's Depression Inventory (CDI), Wechsler Abbreviated Scales of Intelligence, Wechsler Individual Achievement Test-II-Abbreviated, and the Pediatric Inventory of Quality of Life Core Scales 4.0. Regression analyses determined associations of CDI score and depression status with subject characteristics, intellectual and educational levels, and HRQoL. A joint linear mixed model and Weibull model were used to determine the …
The Effect Of Dietary Fruits & Vegetable Consumption And Physical Activity On Obesity In African American Adolescent Females., Tanisha Brooks
The Effect Of Dietary Fruits & Vegetable Consumption And Physical Activity On Obesity In African American Adolescent Females., Tanisha Brooks
Walden Dissertations and Doctoral Studies
Obesity is epidemic among Black adolescent females, and adolescent obesity often leads to adult obesity. Previous research suggests that there may be an interaction between physical activity and dietary fruit and vegetable intake on body mass index (BMI) in obese adolescent females in general, but it was unclear whether the same pattern is evident in Black adolescent females, who, on average, tend to have low levels of physical activity and fruit and vegetable intake. Bandura's social learning theory implies the possibility that adolescent females might model their behaviors on the behavior of others in their high school years, including physical …
Bone Health Echo: Telementoring To Improve Osteoporosis Care, E Michael Lewiecki, Matthew F. Bouchonville, David H. Chafey, Arthur Bankhurst, Sanjeev Arora
Bone Health Echo: Telementoring To Improve Osteoporosis Care, E Michael Lewiecki, Matthew F. Bouchonville, David H. Chafey, Arthur Bankhurst, Sanjeev Arora
Project ECHO Bibliography
Extension for Community Healthcare Outcomes creates knowledge networks that enable a transition from centralized specialty care at academic institutions to empowerment of primary care providers to provide more highly skilled care closer to home.
Working Sandwich Generation Women Utilize Strategies Within And Between Roles To Achieve Role Balance, Kiah Evans, J. L. Millsteed, Janet E. Richmond Phd, Marita Falkmer, Torbjorn Falkmer, Sonya Girdler
Working Sandwich Generation Women Utilize Strategies Within And Between Roles To Achieve Role Balance, Kiah Evans, J. L. Millsteed, Janet E. Richmond Phd, Marita Falkmer, Torbjorn Falkmer, Sonya Girdler
Research outputs 2014 to 2021
Increasingly, women simultaneously balance the roles of mother, parental carer and worker. However, individual role balance strategies among these working 'sandwich' generation women have not been thoroughly explored. Eighteen women combining these three roles were interviewed about their individual role balance strategies. Findings were identified through the framework analysis technique, underpinned by the Model of Juggling Occupations. Achieving and maintaining role balance was explained as a complex process accomplished through a range of strategies. Findings revealed the women used six within-role balance strategies: living with integrity, being the best you can, doing what you love, loving what you do, remembering …
The Influence Of The Sex Of And Prior Relationship Between The Perpetrator And Victim On Perceptions Of Stalking: A Qualitative Analysis, Jeff Bath, Adrian J. Scott
The Influence Of The Sex Of And Prior Relationship Between The Perpetrator And Victim On Perceptions Of Stalking: A Qualitative Analysis, Jeff Bath, Adrian J. Scott
Research outputs 2014 to 2021
The sex of and prior relationship between the perpetrator and victim have been shown to influence perceptions of stalking. To explore the ways in which shared assumptions around these factors interact to shape perceptions of stalking, this study analyses the deliberations of mock juries as they attempt to reach a unanimous verdict on a hypothetical stalking case summary. Twelve mock juries comprising between five and six ‘jurors’ (n = 64) were presented with one of three versions of a case summary (stranger, acquaintance, and ex-partner) describing a man stalking a woman or a woman stalking a man. Thematic analysis shows …
Girls And Stem (Science, Technology, Engineering, And Mathematics) In Catholic Schools: A Mixed Methods Exploration Of Interest, Confidence, And Perceptions Of Stem, Rachel Lynn-Pleis Mckenna
Girls And Stem (Science, Technology, Engineering, And Mathematics) In Catholic Schools: A Mixed Methods Exploration Of Interest, Confidence, And Perceptions Of Stem, Rachel Lynn-Pleis Mckenna
Doctoral Dissertations
Over the past decade, there has been a considerable push in emphasizing STEM—an acronym standing for Science, Technology, Engineering, and Math—as an integral aspect of educational curriculums. Even though research suggests that females tend to outperform males in standardized testing in STEM areas, they remain underrepresented in STEM careers and in the achievement of STEM degrees. In preparing this dissertation, therefore, the researcher investigated this issue by looking specifically at 4th- through 8th-grade girls in Catholic schools in the Diocese of San Jose, CA, which covers the Greater Silicon Valley region, one of the world's epicenters for technological innovations. In …
Singaporean Mothers' Perception Of Their Three-Year-Old Child's Weight Status: A Cross-Sectional Study, Tuck Seng Cheng, Et Al., Yee-Man Ivy Lau
Singaporean Mothers' Perception Of Their Three-Year-Old Child's Weight Status: A Cross-Sectional Study, Tuck Seng Cheng, Et Al., Yee-Man Ivy Lau
Research Collection School of Social Sciences
Objective: Inaccurate parental perception of their child's weight status is commonly reported in Western countries. It is unclear whether similar misperception exists in Asian populations. This study aimed to evaluate the ability of Singaporean mothers to accurately describe their three-year-old child's weight status verbally and visually.
Female Fighters Fight Toward Equal Footing, Desiree A. Mathurin, Ryan Wallerson
Female Fighters Fight Toward Equal Footing, Desiree A. Mathurin, Ryan Wallerson
Capstones
A staple in the boxing world met a primary member of the judo world in an octagon ring housed in the MGM Grand on November 15, 2015. Dubbed by some as the biggest upset of the year,Holly Holm faced off against Ronda Rousey for the Women’s UFC Bantamweight championship and delivered the sweet science to Rousey
Exploring The Factors Of Persistence For African American Senior Nursing Students, Yolanda Nelson
Exploring The Factors Of Persistence For African American Senior Nursing Students, Yolanda Nelson
Theses and Dissertations
African American nursing students experience commonalities within their college experience. Often these students may be faced with challenges, barriers, and/or struggles that may place a hindrance on their success in meeting their educational goals. This qualitative study used a phenomenological approach to explore African American female nursing students perceptions of faculty-student relationships and its implications for persistence. Four African American female nursing students and two nursing faculty agreed to participate in this study. This research study offers an examination of past and present research regarding the history of African American nursing students, health disparity, social justice and diversity within the …
A Quantitative Study Of The Variables That Influence Work-Family Conflict Of Female Counselors, Emeline Eckart
A Quantitative Study Of The Variables That Influence Work-Family Conflict Of Female Counselors, Emeline Eckart
LSU New Orleans Theses and Dissertations
The purpose of this study was to determine the relationship between female counselors’ work-family conflict and their demographic (i.e., ethnicity, age, educational level, and annual household income), occupational (i.e., ethnicity, age, educational level, and annual household income), and family (i.e., marital/partner status; number of children at home under the age of 18; age of youngest child; care of elderly, ill, or disabled family members; source of support; and support) characteristics. Super’s (1990) Life-Space Life-Span theory provided a framework to understand female counselors’ engagement in multiple roles in work and family and the conflict that can result in two directions: work …
The Happy Older Latinos Are Active (Hola) Health Promotion And Prevention Study: Study Protocol For A Pilot Randomized Controlled Trial, Daniel E. Jimenez, Charles F. Reynolds, Margarita Alegría, Philip Harvey, Stephen Bartels
The Happy Older Latinos Are Active (Hola) Health Promotion And Prevention Study: Study Protocol For A Pilot Randomized Controlled Trial, Daniel E. Jimenez, Charles F. Reynolds, Margarita Alegría, Philip Harvey, Stephen Bartels
Dartmouth Scholarship
Results of previous studies attest to the greater illness burden of common mental disorders (anxiety and depression) in older Latinos and the need for developing preventive interventions that are effective, acceptable, and scalable. Happy Older Latinos are Active (HOLA) is a newly developed intervention that uses a community health worker (CHW) to lead a health promotion program in order to prevent common mental disorders among at-risk older Latinos. This pilot study tests the feasibility and acceptability of delivering HOLA to older, at-risk Latinos.
Methods/Design: HOLA is a multi-component, health promotion intervention funded by the National Institute of Mental Health (NIMH). …
Effectiveness Of Food-Demos To Increase Nutrition Knowledge, Megan Hemmelgarn
Effectiveness Of Food-Demos To Increase Nutrition Knowledge, Megan Hemmelgarn
Honors Projects
This research investigated the effectiveness of a one-time food-demo at increasing the knowledge and improving the behavior of vegetable and diary consumption in the diets of college-aged females. Participation included a convenience sample of 26 college-aged females living in residence halls at a Bowling Green State University in Northwest Ohio. Testing was delivered before intervention as a baseline of knowledge and diet behavior. Post-testing was delivered immediately after intervention and evaluated any gain in knowledge from the baseline. One-month after intervention, post 2-testing was distributed evaluating retention of knowledge and behavioral change. Overall, participants experienced knowledge gain immediately after intervention …
Isosorbide Mononitrate In Heart Failure With Preserved Ejection Fraction., Margaret M. Redfield, Kevin J. Anstrom, James A. Levine, Gabe A. Koepp, Barry A. Borlaug, Horng H. Chen, Martin M. Lewinter, Susan M. Joseph, Sanjiv J. Shah, Marc J. Semigran, G. Michael Felker, Robert T. Cole, Gordon R. Reeves, Ryan J. Tedford, W.H. Wilson Tang, Steven E. Mcnulty, Eric J. Velazquez, Monica R Shah, Eugene Braunwald
Isosorbide Mononitrate In Heart Failure With Preserved Ejection Fraction., Margaret M. Redfield, Kevin J. Anstrom, James A. Levine, Gabe A. Koepp, Barry A. Borlaug, Horng H. Chen, Martin M. Lewinter, Susan M. Joseph, Sanjiv J. Shah, Marc J. Semigran, G. Michael Felker, Robert T. Cole, Gordon R. Reeves, Ryan J. Tedford, W.H. Wilson Tang, Steven E. Mcnulty, Eric J. Velazquez, Monica R Shah, Eugene Braunwald
Division of Cardiology Faculty Papers
BACKGROUND: Nitrates are commonly prescribed to enhance activity tolerance in patients with heart failure and a preserved ejection fraction. We compared the effect of isosorbide mononitrate or placebo on daily activity in such patients.
METHODS: In this multicenter, double-blind, crossover study, 110 patients with heart failure and a preserved ejection fraction were randomly assigned to a 6-week dose-escalation regimen of isosorbide mononitrate (from 30 mg to 60 mg to 120 mg once daily) or placebo, with subsequent crossover to the other group for 6 weeks. The primary end point was the daily activity level, quantified as the average daily accelerometer …
Silibinin-Mediated Metabolic Reprogramming Attenuates Pancreatic Cancer-Induced Cachexia And Tumor Growth., Surendra K. Shukla, Aneesha Dasgupta, Kamiya Mehla, Venugopal Gunda, Enza Vernucci, Joshua J. Souchek, Gennifer Goode, Ryan King, Anusha Mishra, Ibha Rai, Sangeetha Nagarajan, Nina V. Chaika, Fang Yu, Surendra K. Shukla
Silibinin-Mediated Metabolic Reprogramming Attenuates Pancreatic Cancer-Induced Cachexia And Tumor Growth., Surendra K. Shukla, Aneesha Dasgupta, Kamiya Mehla, Venugopal Gunda, Enza Vernucci, Joshua J. Souchek, Gennifer Goode, Ryan King, Anusha Mishra, Ibha Rai, Sangeetha Nagarajan, Nina V. Chaika, Fang Yu, Surendra K. Shukla
Journal Articles: Eppley Institute
Pancreatic ductal adenocarcinoma (PDAC) is the fourth leading cause of cancer-related deaths in the US. Cancer-associated cachexia is present in up to 80% of PDAC patients and is associated with aggressive disease and poor prognosis. In the present studies we evaluated an anti-cancer natural product silibinin for its effectiveness in targeting pancreatic cancer aggressiveness and the cachectic properties of pancreatic cancer cells and tumors. Our results demonstrate that silibinin inhibits pancreatic cancer cell growth in a dose-dependent manner and reduces glycolytic activity of cancer cells. Our LC-MS/MS based metabolomics data demonstrates that silibinin treatment induces global metabolic reprogramming in pancreatic …