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Articles 31 - 32 of 32
Full-Text Articles in Entire DC Network
The Effect Of Depression On Bone Mineral Density In College-Aged Females, Caitlin A. Cadematori
The Effect Of Depression On Bone Mineral Density In College-Aged Females, Caitlin A. Cadematori
Senior Honors Projects, 2010-2019
Research regarding the relationship between depression and bone mineral density (BMD) has produced very inconsistent and limited results, especially in younger females. The purpose of this study was to examine the relationship between depression scores and BMD in college-aged female students. Forty-six participants, ages 18-24 (+/-1.0368) completed a 24-hour dietary recall, medical history, Beck’s Depression Inventory and the Depression, Anxiety, and Stress Scale (DASS) and had their femur and sacral vertebrae BMD, z-score, and t-score measured in the Dual X-Ray Absorptiometry (DXA) machine. Participant demographics were analyzed with descriptive statistics and potential variable correlations were analyzed by partial and bipartial …
A Truncation Mutation In Tbc1d4 In A Family With Acanthosis Nigricans And Postprandial Hyperinsulinemia, Satya Dash, Hiroyuki Sano, Justin J. Rochford, Robert K. Semple
A Truncation Mutation In Tbc1d4 In A Family With Acanthosis Nigricans And Postprandial Hyperinsulinemia, Satya Dash, Hiroyuki Sano, Justin J. Rochford, Robert K. Semple
Dartmouth Scholarship
Tre-2, BUB2, CDC16, 1 domain family member 4 (TBC1D4) (AS160) is a Rab-GTPase activating protein implicated in insulin-stimulated glucose transporter 4 (GLUT4) translocation in adipocytes and myotubes. To determine whether loss-of-function mutations in TBC1D4 might impair GLUT4 translocation and cause insulin resistance in humans, we screened the coding regions of this gene in 156 severely insulin-resistant patients. A female presenting at age 11 years with acanthosis nigricans and extreme postprandial hyperinsulinemia was heterozygous for a premature stop mutation (R363X) in TBC1D4. After demonstrating reduced expression of wild-type TBC1D4 protein and expression of the truncated protein in lymphocytes from the proband, …