Digital Commons Network^™

Middle Cerebral O₂ Delivery During The Modified Oxford Maneuver Increases With Sodium Nitroprusside And Decreases During Phenylephrine, Julian M. Stewart, Marvin S. Medow, Andrew Delpozzi, Zachary R. Messer, Courtney Terilli, Christopher E. Schwartz

NYMC Faculty Publications

The modified Oxford maneuver is the reference standard for assessing arterial baroreflex function. The maneuver comprises a systemic bolus injection of 100 μg sodium nitroprusside (SNP) followed by 150 μg phenylephrine (PE). On the one hand, this results in an increase in oxyhemoglobin and total hemoglobin followed by a decrease within the cerebral sample volume illuminated by near-infrared spectroscopy (NIRS). On the other hand, it produces a decrease in cerebral blood flow velocity (CBFv) within the middle cerebral artery (MCA) during SNP and an increase in CBFv during PE as measured by transcranial Doppler ultrasound. To resolve this apparent discrepancy, …

Myelodysplasia: New Approaches, Karen Seiter

NYMC Faculty Publications

The myelodysplastic syndromes (MDS) are a group of clonal hematopoietic disorders characterized by bone marrow failure and a risk of progression to acute myelogenous leukemia (AML). A precise diagnosis is critical, because there is overlap between the clinical and laboratory findings of MDS and other malignant and nonmalignant hematologic disorders. Several prognostic scoring systems (IPSS, WPSS, LR-PSS, and IPSS-R) assess a patient's risk of progression to AML and overall survival. Many patients are elderly, so age and comorbidities are an important consideration. Patients with lower-risk disease are treated with growth factors (erythropoietin stimulating agents and/or G-CSF) and immunomodulatory agents (antithymocyte …

Gene Loss, Thermogenesis, And The Origin Of Birds, Stuart A. Newman, Nadezhda V. Mezentseva, Alexander V. Badyaev

NYMC Faculty Publications

Compared to related taxa, birds have exceptionally enlarged and diversified skeletal muscles, features that are closely associated with skeletal diversification and are commonly explained by a diversity of avian ecological niches and locomotion types. The thermogenic muscle hypothesis (TMH) for the origin of birds proposes that such muscle hyperplasia and the associated skeletal innovations are instead the consequence of the avian clade originating from an ancestral population that underwent several successive episodes of loss of genes associated with thermogenesis, myogenesis, and skeletogenesis. Direct bird ancestors met this challenge with a combination of behavioral strategies (e.g., brooding of nestlings) and acquisition …

Evidence For Novel Aspects Of Nox4 Oxidase Regulation Of Mitochondrial Function And Peroxide Generation In An Endothelial Cell Model Of Senescence, Michael S. Wolin

NYMC Faculty Publications

Observations by Kozieł et al. reported in this issue of the Biochemical Journal suggest the existence of novel regulatory processes associated with new evidence for increased Nox4 (NAPDH oxidase 4) regulation of mitochondrial function in a cultured endothelial cell aging-induced senescence model. Cellular aging appears to promote a Nox4 interaction with mitochondria that disrupts complex I in the electron transport chain and increases the detection of mitochondrial H(2)O(2). Nox4 appears to maintain a highly interconnected mitochondrial network, which may influence mitochondrial fission and/or fusion mechanisms in a manner that could be a contributing factor in the loss of replicative lifespan …

Huntsman Students, Faculty, And Staff Recognized For Contributions, Usu Jon M. Huntsman School Of Business, Allie Jeppson

Jon M. Huntsman School of Business News Collection

Utah State University honored three Huntsman students and the Huntsman Scholar Program with Robins Awards this year, recognizing them for their scholarship, contributions, and trips to the end zone.

2013 May 7, Faculty Senate Minutes, State University Of New York At Cortland, State Univerity Of New York College At Cortland

Minutes

Faculty Senate Minutes No. 14, May 7, 2013

Effect Of Fundamental Frequency At Voice Onset On Vocal Attack Time, Ben C. Watson, R J. Baken, Rick M. Roark, Stephanie Reid, Melissa Ribeiro, Weilyn Tsai

NYMC Faculty Publications

OBJECTIVE: To examine vocal attack time (VAT) values associated with the production of low, mid, and high rates of vocal fold vibration in normal speakers. STUDY DESIGN: Sound pressure (SP) and electroglottographic (EGG) recordings were obtained for eight female and five male subjects while producing multiple tokens of the sustained vowels /ɑ/, /i/, and /u/ at comfortable loudness and at mid, low (-3 semitones), and high (+6 semitones) rates of vocal fold vibration. METHODS: Generalized sinusoidal models of the SP and EGG signals were computed to compare rates of amplitude change. VAT was computed from the time lag of the …

Deconstructing Mtor Complexes In Regulation Of Glioblastoma Multiforme And Its Stem Cells, Meena Jhanwar-Uniyal, Dhruve Jeevan, Jayson Neil, Craig Shannon, Ladislau Albert, Raj Murali

NYMC Faculty Publications

Atypical serine-threonine kinase, mTOR (mechanistic target of Rapamycin; originally coined "mammalian TOR"), exists in two distinct multi-protein complexes termed mTOR complex 1 (mTORC1) and 2 (mTORC2), that senses and integrates a variety of environmental signals to control organism growth and homeostasis via non-overlapping signaling pathways. mTOR belongs to the phosphoinositide 3-kinase (PI3-K)-related kinase family, and an aberrant activation of mTORC1 is a potential contributing factor in uncontrolled cell growth, proliferation, and survival of tumor cells via specific effects on cap-dependent translation initiation, as well as in a more sustained manner via advancing ribosome biogenesis. It is thereby shown to be …

The Unfulfilled Promise Of Management Education (Me): The Role, Value And Purposes Of Me, Howard Thomas, Lynne Thomas, Alex Wilson

Research Collection Lee Kong Chian School Of Business

This paper aims to review the evolution of management education primarily over the last 50 years and seeks to identify the challenges and lessons learned in management education and to assess the potential for change. To gain insight into these issues the authors draw on the perspectives of around 40 key individuals from academia, professional bodies, media, business and students.

Perceptions Of Bp: Successes Of Post 2010 Oil Spill Recover Effort, Jordan R. Mathews

Honors Theses

This purpose of this project was to determine peoples’ opinions of BP’s post 2010 oil spill recovery effort. The researcher examined 65 faculty at the University of Southern Mississippi in order to determine their beliefs, attitudes, and intentions concerning different elements of the BP oil spill recovery effort. The researcher found that there is an overall negative opinion concerning the economic, ecological, and overall recovery effort aspects of the spill. This research suggests that BP still has some work to do in order to restore the gulf coast like they promised.

Fulfilling An Institutional And Public Good Mission: A Case Study Of Access, Renee F. Batman

Department of Educational Administration: Dissertations, Theses, and Student Research

Access to higher education has been and remains a critical issue, yet research typically focuses on students and programs which may overlook the role of the faculty. Through an in-depth case study, the perspectives of tenured and tenure-track faculty at a predominately White, Midwestern land-grant, research institution are described as they relate to issues of student access to higher education. The context of the case was instrumental in understanding faculty perspectives of access and centered on the fundamental notion of education as public good and its association with institutional history and mission. The findings suggest that faculty members uphold the …

Relationship Of Cellular Topoisomerase Iiα Inhibition To Cytotoxicity And Published Genotoxicity Of Fluoroquinolone Antibiotics In V79 Cells, Gary M. Williams, Klaus D. Brunnemann, Daniel J. Smart, David Molina, Alan M. Jeffrey, Jian-Dong Duan, Niels Krebsfaenger, Andreas Kampkoetter, Gabriele Schmuck

NYMC Faculty Publications

Fluoroquinolone (FQ) antibiotics are bacteriocidal through inhibition of the bacterial gyrase and at sufficient concentrations in vitro, they can inhibit the homologous eukaryotic topoisomerase (TOPO) II enzyme. FQ exert a variety of genotoxic effects in mammalian systems through mechanisms not yet established, but which are postulated to involve inhibition of TOPO II enzymes. To assess the relationship of inhibition of cell nuclear TOPO II to cytotoxicity and reported genotoxicity, two FQ, clinafloxacin (CLFX) and lomefloxacin (LOFX), having available genotoxicity data showing substantial differences with CLFX being more potent than LOFX, were selected for study. The relative inhibitory activities of these …

Faculty Senate Summarized Minutes, 4/23/2013, Unm Faculty Senate

Faculty Senate Meeting Minutes, 1920 - 2013

No abstract provided.

2013 April 23, Faculty Senate Minutes, State University Of New York At Cortland

Minutes

No abstract provided.

Anderson,Steven Oral History Interview, David Fletcher

Emeriti Society Oral History Collection

Professor of Biology (1970-1996). Topics include: Recruitment to and involvement in Callison College; death of Callison College; initial loss of tenure and restoration of tenure; transfer to Department of Biological Sciences; anecdotes and wry comments; an individual viewpoint regarding events during career at UOP.

Celebrating Faculty Creative Works 2012, University Of Texas At Arlington Library, Ut Arlington Office Of The Provost

UTA Libraries Staff Publications - Archive

The University of Texas at Arlington Library and the Office of the Provost are pleased to host the fourth Celebration of Faculty Creative Works, an exhibition that showcases the articles, books, art, music, media, patents, and conference activities made by UT Arlington faculty in 2012, as well as outside awards and honors received.

Mek And The Inhibitors: From Bench To Bedside, Akintunde Akinleye, Muhammad Furqan, Nikhil Mukhi, Pavan Ravella, Delong Liu

NYMC Faculty Publications

Four distinct MAP kinase signaling pathways involving 7 MEK enzymes have been identified. MEK1 and MEK2 are the prototype members of MEK family proteins. Several MEK inhibitors are in clinical trials. Trametinib is being evaluated by FDA for the treatment of metastatic melanoma with BRAF V600 mutation. Selumetinib has been studied in combination with docetaxel in phase II randomized trial in previously treated patients with advanced lung cancer. Selumetinib group had better response rate and progression-free survival. This review also summarized new MEK inhibitors in clinical development, including pimasertib, refametinib, PD-0325901, TAK733, MEK162 (ARRY 438162), RO5126766, WX-554, RO4987655 (CH4987655), GDC-0973 …

The Influence Of Faculty Mentors On Junior Pharmacy Faculty Members’ Career Decisions, Nicholas E. Hagemeier, Matthew M. Murawski, Nicholas G. Popovich

ETSU Faculty Works

Objective. To assess junior faculty members’ perceptions regarding the impact of past faculty-mentoring relationships in their career decisions, including the decision to pursue postgraduate training and ultimately an academic career.

Methods. A mixed-mode survey instrument was developed and an invitation to participate in the survey was sent to 2,634 pharmacy faculty members designated as assistant professors in the American Association of Colleges of Pharmacy (AACP) directory data.

Results. Usable responses were received from 1,059 pharmacy faculty members. Approximately 59% of respondents indicated that they had received encouragement from 1 or more faculty mentors that was very or extremely influential in …

2013 April 9, Faculty Senate Minutes, State University Of New York At Cortland

Minutes

Faculty Senate Minutes No. 12, April 9, 2013

Bfs News Online, Georgia Southern University

Art: News & Publications (2008-2023)

• Students, Alumni & Faculty Receive ADDY® Awards

Flier, Faculty Research Lightning Talks, April 3, 2013, University Of South Florida St. Petersburg. Nelson Poynter Memorial Library

Poynter Library Events

Flier for faculty research talks held during the University of South Florida St. Petersburg's Research Month. Talks were by Ella Schmidt, Henry Alegria, Amy Robinson, Phil Trocchia, Vivian Fueyo, Varol Kayhan, Tiffany Chenneville, AnnMarie Gunn, Neil Mattheissen, Deanna Michaels, Zheng Chen, Susan Allen, Mark Durand, and Jamie McHale.

The Loop (Early Spring 2013), Taylor University

The Loop (2012-2017)

The early Spring 2013 travel edition of Taylor University’s The Loop.

The Loop (Spring 2013 Travel Edition), Taylor University

The Loop (2012-2017)

The Spring 2013 edition of Taylor University’s The Loop.

The Loop (Late Spring 2013), Taylor University

The Loop (2012-2017)

The late Spring 2013 edition of Taylor University’s The Loop.

Anti-Seizure Medications And Estradiol For Neuroprotection In Epilepsy: The 2013 Update, Libor Velisek, Nino Nebieridze, Tamar Chachua, Jana Veliskova

NYMC Faculty Publications

Current epilepsy therapy is still symptomatic using anti-seizure, rather than anti-epileptic, medications. This therapy may control the seizure activity but does not prevent or even cure epilepsy. Treatment strategies that could interfere with the process leading to epilepsy (epileptogenesis) would have significant benefits over the current approaches. Neuronal damage contributing to remodeling of the neuronal networks (such as in the hippocampus during temporal lobe epilepsy) is one of the significant components of ongoing epileptogenesis. Thus, treatment strategies alleviating seizure-induced neuronal damage and network reorganization may become powerful tools fighting the deteriorating process of epileptogenesis. Current anti-seizure medications, especially valproic acid, …

Pacific Review Spring 2013, Alumni Association Of The University Of The Pacific

Pacific Magazine and Pacific Review

No abstract provided.

[The Great European Georg Friedrich Nicolai: Physician And Pacifist. Berlin, Germany, 1874 - Santiago, Chile, 1964], Felipe Cabello C

NYMC Faculty Publications

Georg Friedrich Nicolai (1874-1964) was a German physician and physiologist whose pacifism during the First World War led him in 1914 to cosign with W. J. Foerster, A. Einstein and O. Bueck a "Manifesto to the Europeans" against the entry of Germany into the war and the invasion of Belgium. As a result of this appeal and his strong pacifism, Nicolai lost his positions as cardiologist to the German royal family, professor at the University of Berlin and chief of laboratory at the Charite hospital also in Berlin, and was sent as a garrison physician in Graundenz, in today's Poland. …

Perceptions Of Creativity Among Faculty In Higher Education, Ellie Melissa Potter

Masters Theses

Higher education instructors do not sufficiently incorporate creativity in the teaching and learning environments within which they operate. While there is a great deal of research available regarding creativity and primary or secondary education, there is little research available regarding creativity and higher education. This study contributes to that gap of knowledge by surveying faculty members in one institution of higher education in order to understand their perspectives regarding creativity, both as it relates to being a creative individual and to teaching others to be creative themselves. There were 358 faculty members who participated in the online survey designed specifically …

Spring 2013, College Of The Pacific

History News

No abstract provided.

Faculty Senate Summarized Minutes, 3/26/2013, Unm Faculty Senate

Faculty Senate Meeting Minutes, 1920 - 2013

No abstract provided.