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Muscle Specific Nucleus Ambiguus Neurons Isolation And Culturing, Ignacio Hernandez-Morato, Michael J. Pitman, Sansar Sharma

NYMC Faculty Publications

BACKGROUND: Peripheral nerve injury leads to a regenerative state. However, the reinnervation process is highly non-selective. Growing axons are often misrouted and establish aberrant synapsis to abductor or adductor muscles. Determining the complex properties of abductor and adductor motoneurons in a neuron culture, may lay the groundwork for future studies on axon guidance, leading to a clinical treatment for a selective reinnervation. NEW METHOD: In the present study we develop a neuron culture protocol to isolate recurrent laryngeal nerve abductor and adductor motoneurons in order to study their unique properties. Comparison with existing methods the best period to perform the …

Resuscitation Of Potentially Stillborn Periviable Neonates: Who Lives, Who Dies And Who Gets Missed?, Edmund F. La Gamma, J Lena Kim, Shetal Shah

NYMC Faculty Publications

No abstract provided.

Selective Inhibition Of Metabotropic Glutamate Type 1 Alpha Receptor (Mglur1Α) Reduces Cell Proliferation And Migration Following Status Epilepticus In Early Development, L K. Friedman, A Sharma, M Corcia, T Webster, L Qazi, D Simsovits, Y Khalil, S Hu, M Kantrowitz, H Hong

NYMC Faculty Publications

The present study examined whether a single or multiple episode(s) of status epilepticus induced with kainic acid (KA) during the first 3 weeks of postnatal (P) development would aberrantly stimulate proliferation zones that alters migration to potentially injured areas and whether they would be blocked by selective Group I mGluR antagonists. mGluR1α (LY367385) and mGluR5 (MPEP) antagonists were administered 2h following KA-induced status epilepticus and animals were examined after 7days. Proliferating cells of the subventricular zone (SVZ), third ventricle, hippocampus, amygdala cortical complex were analyzed with the proliferative marker, Ki67; and two complementary retrograde dye tracers. Proliferation increased in extrahippocampal …

Delivery Room Hospice, Lyndsey R. Garbi, Shetal Shah, Edmund F. La Gamma

NYMC Faculty Publications

UNLABELLED: Advances in perinatal science over the past five decades have reduced the practical 'threshold of viability' by approximately one week every 10 years such that survivors are expected as early as 22 weeks. Ethical standards regarding treatment of this periviable patient population remain enigmatic. CONCLUSION: We review limitations in the current ethical rationale for caring for these infants in the delivery room and introduce an alternative utilising a delivery room hospice care approach involving the administration of opioids.

The Will To Prevail: Inside The Legal Battle To Save Sweet Briar, William H. Hurd, Ashley L. Taylor Jr., Nancyellen Keane, Stephen C. Piepgrass, C. Reade Jacob Jr., James M. Giudice, J. Westwood Smithers Iii

University of Richmond Law Review

Part I provides an in-depth factual overview, beginning with the Sweet Briar College's founding in the early 1900s. The commentary then turns to the controversial decision to close and discusses the facts and legal theories of the case, the decisions by the circuit court and the Supreme Court of Virginia, and the eventual settlement that kept the school alive.

In Part II, the discussion shifts to the landmark nature of this case, not only for Sweet Briar College, but also for other Virginia colleges and non-profits around the country. The essay analyzes the legal questions arising from the case, including …

Social Participation And Life Satisfaction Among Widowed Older Adults In China, Yawen Li, Ling Xu, Joohong Min, Iris Chi, Bin Xie

Social Work Faculty Publications & Presentations-Archive

Aim: Little is known about how widowed older adults in China adjust during widowhood. This paper examines the relationship between their changes in social participation following spousal loss and their reported life satisfaction. Methods: Using two-wave (2000 and 2006) national representative data from China, we regressed measures of widowhood status, changes of social participation, health function, financial strain as well as living arrangement on life satisfaction after adjusting for baseline life satisfaction and other sociodemographic variables. Results: Increased social participation was related to higher levels of life satisfaction. This study did not find evidence that individuals who experienced widowhood would …

My News

My News (2014-2020)

• Georgia Southern hosts Social Gerontology Conference
• STEM Education explores opportunities in India
• Faculty and alumni present research at 26th Annual EECERA Conference

• Two nursing students awarded the St. Joseph’s/Candler Georgia Southern University Nightingale Scholarship

• History professor wins award for new book on women apparel workers

• BFSDoArt to host several events this month featuring acclaimed professional artists, Manuel Lima and Yoko Sekino­Bové

Chhs News, College Of Health And Human Sciences, Georgia Southern University

College of Health Professions: News & Publications (2012-2023)

No abstract provided.

The Loop (Fall 2016), Taylor University

The Loop (2012-2017)

The late Fall 2016 edition of Taylor University’s The Loop.

The Ep3 Receptor Regulates Water Excretion In Response To High Salt Intake, Shoujin Hao, Annmarie Dellipizzi, Mariana Quiroz-Munoz, Houli Jiang, Nicholas R. Ferreri

NYMC Faculty Publications

The mechanisms by which prostanoids contribute to the maintenance of whole body water homeostasis are complex and not fully understood. The present study demonstrates that an EP3-dependent feedback mechanism contributes to the regulation of water homeostasis under high-salt conditions. Rats on a normal diet and tap water were placed in metabolic cages and given either sulprostone (20 μg·kg·day) or vehicle for 3 days to activate EP3 receptors in the thick ascending limb (TAL). Treatment was continued for another 3 days in rats given either 1% NaCl in the drinking water or tap water. Sulprostone decreased expression of cyclooxygenase 2 (COX-2) …

Changes In Neurotrophic Factors Of Adult Rat Laryngeal Muscles During Nerve Regeneration, Ignacio Hernandez-Morato, Sansar Sharma, Michael J. Pitman

NYMC Faculty Publications

Injury to the recurrent laryngeal nerve (RLN) leads to the loss of ipsilateral laryngeal fold movement, with dysphonia, and occasionally dysphagia. Functional movement of the vocal folds is never restored due to misrouting of regenerating axons to agonist and antagonist laryngeal muscles. Changes of neurotrophic factor expression within denervated muscles occur after nerve injury and may influence nerve regeneration, axon guidance and muscle reinnervation. This study investigates the expression of certain neurotrophic factors in the laryngeal muscles during the course of axonal regeneration using RT-PCR. The timing of neurotrophic factor expression was correlated to the reinnervation of the laryngeal muscles …

Hypocretin/Orexin Peptides Alter Spike Encoding By Serotonergic Dorsal Raphe Neurons Through Two Distinct Mechanisms That Increase The Late Afterhyperpolarization, Masaru Ishibashi, Iryna Gumenchuk, Kenichi Miyazaki, Takafumi Inoue, William N. Ross, Christopher S. Leonard

NYMC Faculty Publications

UNLABELLED: Orexins (hypocretins) are neuropeptides that regulate multiple homeostatic processes, including reward and arousal, in part by exciting serotonergic dorsal raphe neurons, the major source of forebrain serotonin. Here, using mouse brain slices, we found that, instead of simply depolarizing these neurons, orexin-A altered the spike encoding process by increasing the postspike afterhyperpolarization (AHP) via two distinct mechanisms. This orexin-enhanced AHP (oeAHP) was mediated by both OX1 and OX2 receptors, required Ca(2+) influx, reversed near EK, and decayed with two components, the faster of which resulted from enhanced SK channel activation, whereas the slower component decayed like a slow AHP …

Prevalence And Determinants Of Metabolic Syndrome In Qatar: Results From A National Health Survey, Mohamed Al-Thani, Al Anoud M. Al-Thani, Sohaila Cheema, Javaid Sheikh, Ravinder Mamtani, Albert B. Lowenfels, Walaa F. Al-Chetachi, Badria Almalki, Shamseldin A. Hassan Khalifa, Ahmad O. Haj Bakri, Patrick Maisonneuve

NYMC Faculty Publications

OBJECTIVES: To determine optimum measurements for abdominal obesity and to assess the prevalence and determinants of metabolic syndrome in Qatar.

DESIGN: National health survey.

SETTING: Qatar National STEPwise Survey conducted by the Supreme Council of Health during 2012.

PARTICIPANTS: 2496 Qatari citizens aged 18-64 representative of the general population.

PRIMARY AND SECONDARY OUTCOME MEASURES: Measure of obesity (body mass index, waist circumference or waist-to-height ratio) that best identified the presence of at least 2 other factors of metabolic syndrome; cut-off values of waist circumference; frequency of metabolic syndrome.

RESULTS: Waist circumference ≥102 for men and ≥94 cm for women was …

Microrna-140 Is Elevated And Mitofusin-1 Is Downregulated In The Right Ventricle Of The Sugen5416/Hypoxia/Normoxia Model Of Pulmonary Arterial Hypertension, Sachindra Raj Joshi, Vidhi Dhagia, Salina Gairhe, John G. Edwards, Ivan F. Mcmurtry, Sachin A. Gupte

NYMC Faculty Publications

Heart failure, a major cause of morbidity and mortality in patients with pulmonary arterial hypertension (PAH), is an outcome of complex biochemical processes. In this study, we determined changes in microRNAs (miRs) in the right and left ventricles of normal and PAH rats. Using an unbiased quantitative miR microarray analysis, we found 1) miR-21-5p, miR-31-5 and 3p, miR-140-5 and 3p, miR-208b-3p, miR-221-3p, miR-222-3p, miR-702-3p, and miR-1298 were upregulated (>2-fold; P < 0.05) in the right ventricle (RV) of PAH compared with normal rats; 2) miR-31-5 and 3p, and miR-208b-3p were upregulated (>2-fold; P < 0.05) in the left ventricle plus septum (LV+S) of PAH compared with normal rats; 3) miR-187-5p, miR-208a-3p, and miR-877 were downregulated (>2-fold; P < 0.05) in the RV of PAH compared with normal rats; and 4) no miRs were up- or downregulated with >2-fold in LV+S compared with RV of PAH and normal. Upregulation of miR-140 and miR-31 in the hypertrophic RV was further confirmed by quantitative PCR. …

Newsletter, University Of South Florida Retired Faculty And Staff Association, Fall 2016, University Of South Florida St. Petersburg Retired Faculty & Staff Association

USF St. Petersburg Retired Faculty and Staff Association

The Fall 2016 issue of the University of South Florida St. Petersburg's Retired Faculty and Staff Association newsletter.

On Shared Governance, Missed Opportunities, And Student Protests, Nancy B. Rapoport

Nevada Law Journal

No abstract provided.

Colorectal Cancer On The Decline, Albert B. Lowenfels, Patrick Maisonneuve, Ravinder Mamtani

NYMC Faculty Publications

No abstract provided.

Colorectal Cancer On The Decline, Albert B. Lowenfels, Patrick Maisonneuve, Ravi Mamtani

NYMC Faculty Publications

No abstract provided.

Deep Phylogenomics Of A Tandem-Repeat Galectin Regulating Appendicular Skeletal Pattern Formation, Ramray Bhat, Mahul Chakraborty, Tilmann Glimm, Thomas A. Stewart, Stuart A. Newman

NYMC Faculty Publications

BACKGROUND: A multiscale network of two galectins Galectin-1 (Gal-1) and Galectin-8 (Gal-8) patterns the avian limb skeleton. Among vertebrates with paired appendages, chondrichthyan fins typically have one or more cartilage plates and many repeating parallel endoskeletal elements, actinopterygian fins have more varied patterns of nodules, bars and plates, while tetrapod limbs exhibit tandem arrays of few, proximodistally increasing numbers of elements. We applied a comparative genomic and protein evolution approach to understand the origin of the galectin patterning network. Having previously observed a phylogenetic constraint on Gal-1 structure across vertebrates, we asked whether evolutionary changes of Gal-8 could have critically …

Newsroom, Georgia Southern University

Newsroom (2006-2023)

• Campus safety at Georgia Southern is within closer reach with LiveSafe app
• '2016 Faculty Exhibition' Opens at Center for Art & Theatre
• Lecture on immigration detention and human rights defenders on Aug. 18
• Georgia Southern brings renewable energy research to schools in high-need rural Georgia
• Georgia Southern faculty, staff gear up for fall semester

20-Hete Contributes To Ischemia-Induced Angiogenesis, Li Chen, Gregory Joseph, Frank F. Zhang, Huyen Nguyen, Houli Jiang, Katherine H. Gotlinger, John R. Falck, Jing Yang, Michal L. Schwartzman, Austin M. Guo

NYMC Faculty Publications

Angiogenesis is an important adaptation for recovery from peripheral ischemia. Here, we determined whether 20-hydroxyeicosatetraenoic acid (20-HETE) contributes to ischemia-induced angiogenesis and assessed its underlying molecular and cellular mechanisms using a mouse hindlimb-ischemia angiogenesis model. Hindlimb blood flow was measured by Laser Doppler Perfusion Imaging and microvessel density was determined by CD31 and tomato lectin staining. We found that systemic and local administration of a 20-HETE synthesis inhibitor, DDMS, or a 20-HETE antagonist, 6,15-20-HEDGE significantly reduced blood flow recovery and microvessel formation in response to ischemia. 20-HETE production, measured by LC/MS/MS, was markedly increased in ischemic muscles (91±11 vs. 8±2pg/mg …

Pacific Review Fall 2016, Alumni Association Of The University Of The Pacific

Pacific Magazine and Pacific Review

No abstract provided.

Undetected And Unvoiced, University Of Dayton

News Releases

Every minute in the United States, one person will have a heart attack, two will suffer strokes, and three women will nearly bleed to death while giving birth. Behind the statistics from the Centers for Disease Control, Scott and Michelle Hall say there is a need not being met by the health care industry: the emotional toll.

Prefrontal Responses To Stroop Tasks In Subjects With Post-Traumatic Stress Disorder Assessed By Functional Near Infrared Spectroscopy, Amarnath Yennu, Fenghua Tian, Alexa Smith-Osborne, Robert J. Gatchel, Fu Lye Woon, Hanli Liu

Psychology Faculty Publications - Archive

No abstract provided.

Opportunities Abound, University Of Dayton

News Releases

A University of Dayton education means hands-on opportunities for students to transform the world. Nine students from three countries in four departments hope their work someday passes the smell test.

How Challenged And Overwhelmed Faculty Become Supported And Empowered In Curriculum Development, Evaluation And Revision, Meredith L. Roberts

International Nursing Research Congress (INRC)

Session presented on Sunday, July 24, 2016:

Purpose: To discover the perceptions of faculty related to their preparedness and confidence in developing, evaluating, and revising nursing curriculum and to use faculty's constructions to develop a theory (challenged and overwhelmed) and model of understanding (Supported and Empowered) to support faculty's growth and competence in curriculum development, evaluation and revisio.

Methods: Constructivist Grounded Theory explored and compared the perceptions and processes of nursing faculty regarding their preparedness and confidence in developing, evaluating, and revising curriculum and the processes used for preparation. The Excellence in Nursing Education Model (NLN, 2006) assisted in providing …

'In The Family Way:' Linking Dynamics From Family Of Origin With Subsequent Workplace Bullying Experiences, Monica Kennison

International Nursing Research Congress (INRC)

Session presented on Friday, July 22, 2016:

Purpose: Our early family experiences follow us throughout life, influencing our beliefs and values in the long term. As Heidegger intimated, we are our histories. In the context of the workplace, memories of early family experiences--still active in our day-to-day thought processes and emotions--are melded with experiences taking place in real time, yielding a sense of self-as-coworker that incorporates both past and present. Confidence, interpersonal comfort, and feelings of safety and of support from peers and administrators thus evolve as functions of the commingling of personal history and workplace engagement (Anda et al., …

Difficult Dialogues: Faculty Responses To A Gender Bias Literacy Training Program, Carol Isaac, Linda Baier Manwell, Patricia G. Devine, Cecilia Ford, Jennifer T. Sheridan, Molly Carnes

The Qualitative Report

Diversity training is challenging and can evoke strong emotional responses from participants including resistance, shame, confusion, powerlessness, defensiveness, and anger. These responses create complex situations for both presenters and other learners. We observed 3 experienced presenters as they implemented 41 gender bias literacy workshops for 376 faculty from 42 STEMM (science, technology, engineering, mathematics, medicine) departments at one Midwestern university. We recorded questions and answers as well as participants’ non-verbal activity during each 2.5-hour workshop. Employing content analysis and critical incident technique, we identified content that elicited heightened activity and challenging dialogues among presenters and faculty. Results from analysis of …

My News

My News (2014-2020)

• Georgia Southern University welcomes Jaimie Hebert, Ph.D., as 13th president
• Wherever life takes you
• Georgia Southern Multimedia Development Center wins Emmy® Award for Best Live Audio
• Daniel J. Cox, Ph.D., to serve as founding chair of the Department of Manufacturing Engineering
• Georgia Southern faculty continue excellence in 2016
• Georgia Southern student films featured at Cannes