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Fall 2013, College Of The Pacific

History News

No abstract provided.

Exploring Heterosexist Bias And Oppressive Bullying In Anti-Bullying Prevention Programs, Shayna Yamashiro

UNLV Theses, Dissertations, Professional Papers, and Capstones

Children in the K-12 school environment who identify in the sexually underrepresented groups experience the effects of heterosexism, which is a manifestation of oppressive bullying. This work explores and analyzes the results of Anti-Bullying Prevention Pilot Program (ABPPP) which is a large-scale three-year evaluation. This study analyzed qualitative data (structured interviews) by utilizing a Consensual Qualitative Research (CQR) and Mixed Methods approach to find the emergent theme of heterosexism. Grounded Theory was then used to code that information. This work found thick descriptions which illustrated the presence of heterosexist bias in the qualitative data. Thus, this writer proposes a model …

Volatile Organic Compound Emissions From Surface Coating Facilities: Characterization Of Facilities, Estimation Of Emission Rates, And Dispersion Modeling Of Off-Site Impacts, Annabrabha Athappan, Sulak Sumitsawan, Roja Haritha Gangupomu, Ketwalee Kositkanawuth, Parthen Parikh, Benjamin Nmai Afotey, Neelesh Sule, Sahithi Raj Kalidindi, Melanie L. Sattler, Yvette Pearson Weatherton

Civil Engineering Faculty Publications - Archive

Surface coating facilities are major sources of volatile organic compounds (VOCs) in urban areas. These VOCs can contribute to ground-level ozone formation, and many are hazardous air pollutants (HAPs), including xylene, ethylbenzene, and toluene. This project was conducted in order to provide information for updating the Texas Commission on Environmental Quality (TCEQ), USA, permit by rule for Surface Coating Facilities. Project objectives were: 1) To develop a database of information regarding surface coating facilities in Texas; 2) To estimate maximum emission rates for various VOC species from surface coating facilities in Texas; 3) To conduct dispersion modeling to estimate off-site …

Volume 8, 2013, Csusb

Scholarship in Action newsletter

What to look for in this issue...

• Faculty Research
  • Bryan Haddock, BRAD p.1
• Awards p.3
• Awards Last 10 years p.5
• Did you Know? p.5
• Presentations, Publications, Exhibitons and Performances p.6
• News from NSF p.21
• Helpful Hints p.22
• Contact Information p.22

Physical, Behavioral, And Psychological Traits Of Gay Men Identifying As Bears, David A. Moskowitz, Jonathan Turrubiates, Hector Lozano, Christopher Hajek

NYMC Faculty Publications

The Bear community exists as a subculture in reaction to the larger gay community. It rejects the normative idealized male beauty revered by mainstream gay men. While qualitative data document such self-identifiers as masculine-acting gay men who weigh more and have more body hair, there has to date been no quantitative analysis of this group's characteristics. In response, we conducted two large-scale studies of gay men identifying as Bears (n = 469) to survey their self-reported physical, behavioral, and psychological traits. Our studies indicated that Bears were more likely to be hairier, heavier, and shorter than mainstream gay men. They …

Resveratrol And Its Metabolites Modulate Cytokine-Mediated Induction Of Eotaxin-1 In Human Pulmonary Artery Endothelial Cells, Joseph M. Wu, Tze-Chen Hsieh, Ching-Jen Yang, Susan C. Olson

NYMC Faculty Publications

Coronary heart disease (CHD) is a leading cause of death in many developed countries. Evidence has long implicated endothelial injury and inflammation as apical events in the pathogenesis of atherosclerosis, the primary cause of CHD. Numerous risk factors contribute to a damaged, inflamed endothelium. Conversely, cardioprotective agents targeting the dysfunctional endothelium have also been identified, notably from dietary sources. We have used cultured human pulmonary artery endothelial cells (HPAECs) to test the diet-mediated cardioprotective hypothesis. In this review, we summarize our recent findings on control of transcription and expression of inflammation biomarker eotaxin-1 in HPAECs exposed to single or combined …

Β-Adrenergic Blockade In Cardiovascular Disease, William H. Frishman

NYMC Faculty Publications

The development and subsequent clinical application of the β-adrenergic receptor blocking drugs represent one of the major advances in human pharmacotherapeutics. No other class of synthetic drugs has demonstrated such widespread therapeutic utility for the treatment and prevention of so many cardiovascular diseases. In addition, these drugs have proven to be molecular probes that have contributed to our understanding of the disease, and on the molecular level, both the structure and function of the 7 transmembrane G protein receptors that mediate the actions of many different hormones, neurotransmitters, and drugs. The evolution of β-blocker drug development has led to refinements …

Transcriptome Profiling Of Hippocampal Ca1 After Early-Life Seizure-Induced Preconditioning May Elucidate New Genetic Therapies For Epilepsy, L K. Friedman, J Mancuso, A Patel, V Kudur, J R. Leheste, S Iacobas, J Botta, D A. Iacobas, D C. Spray

NYMC Faculty Publications

Injury of the CA1 subregion induced by a single injection of kainic acid (1 × KA) in juvenile animals (P20) is attenuated in animals with two prior sustained neonatal seizures on P6 and P9. To identify gene candidates involved in the spatially protective effects produced by early-life conditioning seizures we profiled and compared the transcriptomes of CA1 subregions from control, 1 × KA- and 3 × KA-treated animals. More genes were regulated following 3 × KA (9.6%) than after 1 × KA (7.1%). Following 1 × KA, genes supporting oxidative stress, growth, development, inflammation and neurotransmission were upregulated (e.g. Cacng1, …

Concise Review: Endothelial Stem And Progenitor Cells And Their Habitats, Michael S. Goligorsky, Petri Salven

NYMC Faculty Publications

Recent studies on the stem cell origins of regenerating tissues have provided solid evidence in support of the role of the resident cells, rather than bone marrow-derived or transplanted stem cells, in restoring tissue architecture after an injury. This is also true for endothelial stem and progenitor cells: local pools exist in the vascular wall, and those cells are the primary drivers of vascular regeneration. This paradigm shift offers an opportunity to rethink and refine our understanding of the multiple therapeutic effects of transplanted endothelial progenitor cells, focusing on their secretome, sheddome, intercellular communicational routes, and other potential ways to …

Suny Cortland Handbook 2013 Revisions, State University Of New York At Cortland

SUNY Cortland Handbook

College Handbook Revisions enacted June/July 2013 by College Council

Leadership Considerations For Executive Vice Chairs, New Chairs, And Chairs In The 21st Century., Elisabeth J.S. Kunkel, Jon A. Lehrmann, Michael J. Vergare, Laura Weiss Roberts

Department of Psychiatry and Human Behavior Faculty Papers

The need to fulfill academic goals in the context of significant economic challenges, new regulatory requirements, and ever-changing expectations for leadership requires continuous adaptation. This paper serves as an educational resource for emerging leaders from the literature, national leaders, and other “best practices” in the following domains: 1. Mentorship; 2. Faculty Development; 3. Promotion; 4. Demonstrating value in each of the academic missions; 5. Marketing and communications; and 6. Barriers

Spontaneous Fluctuation Indices Of The Cardiovagal Baroreflex Accurately Measure The Baroreflex Sensitivity At The Operating Point During Upright Tilt, Christopher E. Schwartz, Marvin S. Medow, Zachary Messer, Julian M. Stewart

NYMC Faculty Publications

Spontaneous fluctuation indices of cardiovagal baroreflex have been suggested to be inaccurate measures of baroreflex function during orthostatic stress compared with alternate open-loop methods (e.g. neck pressure/suction, modified Oxford method). We therefore tested the hypothesis that spontaneous fluctuation measurements accurately reflect local baroreflex gain (slope) at the operating point measured by the modified Oxford method, and that apparent differences between these two techniques during orthostasis can be explained by a resetting of the baroreflex function curve. We computed the sigmoidal baroreflex function curves supine and during 70° tilt in 12 young, healthy individuals. With the use of the modified Oxford …

Two Distinct Modes Of Exocytotic Fusion Pore Expansion In Large Astrocytic Vesicles, Hong Peng, Ning Kang, Jun Xu, Patric K. Stanton, Jian Kang

NYMC Faculty Publications

Formation of the fusion pore is a central question for regulated exocytosis by which secretory cells release neurotransmitters or hormones. Here, by dynamically monitoring exocytosis of large vesicles (2-7 μM) in astrocytes with two-photon microscopy imaging, we found that the exocytotic fusion pore was generated from the SNARE-dependent fusion at a ring shape of the docked plasma-vesicular membrane and the movement of a fusion-produced membrane fragment. We observed two modes of fragment movements, 1) a shift fragment that shifted to expand the fusion pore and 2) a fall-in fragment that fell into the collapsed vesicle to expand the fusion pore. …

Vernacular Explanations Of Causation In Lay Health Discourse, Laurel Smith Stvan

Linguistics & TESOL Faculty Publications & Presentations - Archive

Few linguistic works exam vernacular terms for health concepts rather than technical medical terms (cf. Rueda-Baclig & Florencio 2003). The prevalence of conversations on food, sleep, exercise, and illness – and the ordinariness of the words – leads to aspects of lexical misinterpretation remaining understudied. Lay terms with multiple senses are studied here to determine effects on misunderstanding of causality in health discussions.

Possible Treatment Of End-Stage Hyperammonemic Encephalopathy By Inhibition Of Glutamine Synthetase, Arthur J. Cooper

NYMC Faculty Publications

Glutamine synthetase (GS) is highly active in astrocytes, and these cells are physiologically and morphologically compromised by hyperammonemia. Hyperammonemia in end-stage acute liver failure (ALF) is often associated with cerebral edema and astrocyte pathology/swelling. Many studies of animal models of hyperammonemia, and, more recently, nuclear magnetic resonance studies of liver disease patients, have shown that cerebral glutamine is elevated in hyperammonemia, contributing to the edema and encephalopathy. The GS inhibitor L-methionine-S,R-sulfoximine (MSO) is protective in animal models against acute ammonia intoxication. MSO is also an inhibitor of glutamate cysteine ligase, is converted to metabolic products, and causes convulsions at high …

Middle Cerebral O₂ Delivery During The Modified Oxford Maneuver Increases With Sodium Nitroprusside And Decreases During Phenylephrine, Julian M. Stewart, Marvin S. Medow, Andrew Delpozzi, Zachary R. Messer, Courtney Terilli, Christopher E. Schwartz

NYMC Faculty Publications

The modified Oxford maneuver is the reference standard for assessing arterial baroreflex function. The maneuver comprises a systemic bolus injection of 100 μg sodium nitroprusside (SNP) followed by 150 μg phenylephrine (PE). On the one hand, this results in an increase in oxyhemoglobin and total hemoglobin followed by a decrease within the cerebral sample volume illuminated by near-infrared spectroscopy (NIRS). On the other hand, it produces a decrease in cerebral blood flow velocity (CBFv) within the middle cerebral artery (MCA) during SNP and an increase in CBFv during PE as measured by transcranial Doppler ultrasound. To resolve this apparent discrepancy, …

Myelodysplasia: New Approaches, Karen Seiter

NYMC Faculty Publications

The myelodysplastic syndromes (MDS) are a group of clonal hematopoietic disorders characterized by bone marrow failure and a risk of progression to acute myelogenous leukemia (AML). A precise diagnosis is critical, because there is overlap between the clinical and laboratory findings of MDS and other malignant and nonmalignant hematologic disorders. Several prognostic scoring systems (IPSS, WPSS, LR-PSS, and IPSS-R) assess a patient's risk of progression to AML and overall survival. Many patients are elderly, so age and comorbidities are an important consideration. Patients with lower-risk disease are treated with growth factors (erythropoietin stimulating agents and/or G-CSF) and immunomodulatory agents (antithymocyte …

Gene Loss, Thermogenesis, And The Origin Of Birds, Stuart A. Newman, Nadezhda V. Mezentseva, Alexander V. Badyaev

NYMC Faculty Publications

Compared to related taxa, birds have exceptionally enlarged and diversified skeletal muscles, features that are closely associated with skeletal diversification and are commonly explained by a diversity of avian ecological niches and locomotion types. The thermogenic muscle hypothesis (TMH) for the origin of birds proposes that such muscle hyperplasia and the associated skeletal innovations are instead the consequence of the avian clade originating from an ancestral population that underwent several successive episodes of loss of genes associated with thermogenesis, myogenesis, and skeletogenesis. Direct bird ancestors met this challenge with a combination of behavioral strategies (e.g., brooding of nestlings) and acquisition …

Evidence For Novel Aspects Of Nox4 Oxidase Regulation Of Mitochondrial Function And Peroxide Generation In An Endothelial Cell Model Of Senescence, Michael S. Wolin

NYMC Faculty Publications

Observations by Kozieł et al. reported in this issue of the Biochemical Journal suggest the existence of novel regulatory processes associated with new evidence for increased Nox4 (NAPDH oxidase 4) regulation of mitochondrial function in a cultured endothelial cell aging-induced senescence model. Cellular aging appears to promote a Nox4 interaction with mitochondria that disrupts complex I in the electron transport chain and increases the detection of mitochondrial H(2)O(2). Nox4 appears to maintain a highly interconnected mitochondrial network, which may influence mitochondrial fission and/or fusion mechanisms in a manner that could be a contributing factor in the loss of replicative lifespan …

2013 May 7, Faculty Senate Minutes, State University Of New York At Cortland, State Univerity Of New York College At Cortland

Minutes

Faculty Senate Minutes No. 14, May 7, 2013

Reaching Out To Faculty: Leveraging Professional And Social Interactions To Meet Information Needs, Valerie E. Perry

Library Presentations

Objectives: To apply the subject expertise of a life sciences librarian in serving the One Health information needs of the University of Kentucky College of Agriculture faculty and other researchers employing animal research protocols through professional involvement, education, and social activities.

Methods Setting: A large research university with diverse use of animal research across the disciplinary faculties. Population: Researchers in the University of Kentucky College of Agriculture and those in the medical, social, and life sciences--such as dentistry, medicine, pharmacy, biology and psychology--who use animals in their research. Exposure: Provide and promote information resources and services during 2010-2012 through a …

Effect Of Fundamental Frequency At Voice Onset On Vocal Attack Time, Ben C. Watson, R J. Baken, Rick M. Roark, Stephanie Reid, Melissa Ribeiro, Weilyn Tsai

NYMC Faculty Publications

OBJECTIVE: To examine vocal attack time (VAT) values associated with the production of low, mid, and high rates of vocal fold vibration in normal speakers. STUDY DESIGN: Sound pressure (SP) and electroglottographic (EGG) recordings were obtained for eight female and five male subjects while producing multiple tokens of the sustained vowels /ɑ/, /i/, and /u/ at comfortable loudness and at mid, low (-3 semitones), and high (+6 semitones) rates of vocal fold vibration. METHODS: Generalized sinusoidal models of the SP and EGG signals were computed to compare rates of amplitude change. VAT was computed from the time lag of the …

Deconstructing Mtor Complexes In Regulation Of Glioblastoma Multiforme And Its Stem Cells, Meena Jhanwar-Uniyal, Dhruve Jeevan, Jayson Neil, Craig Shannon, Ladislau Albert, Raj Murali

NYMC Faculty Publications

Atypical serine-threonine kinase, mTOR (mechanistic target of Rapamycin; originally coined "mammalian TOR"), exists in two distinct multi-protein complexes termed mTOR complex 1 (mTORC1) and 2 (mTORC2), that senses and integrates a variety of environmental signals to control organism growth and homeostasis via non-overlapping signaling pathways. mTOR belongs to the phosphoinositide 3-kinase (PI3-K)-related kinase family, and an aberrant activation of mTORC1 is a potential contributing factor in uncontrolled cell growth, proliferation, and survival of tumor cells via specific effects on cap-dependent translation initiation, as well as in a more sustained manner via advancing ribosome biogenesis. It is thereby shown to be …

Fulfilling An Institutional And Public Good Mission: A Case Study Of Access, Renee F. Batman

Department of Educational Administration: Dissertations, Theses, and Student Research

Access to higher education has been and remains a critical issue, yet research typically focuses on students and programs which may overlook the role of the faculty. Through an in-depth case study, the perspectives of tenured and tenure-track faculty at a predominately White, Midwestern land-grant, research institution are described as they relate to issues of student access to higher education. The context of the case was instrumental in understanding faculty perspectives of access and centered on the fundamental notion of education as public good and its association with institutional history and mission. The findings suggest that faculty members uphold the …

Relationship Of Cellular Topoisomerase Iiα Inhibition To Cytotoxicity And Published Genotoxicity Of Fluoroquinolone Antibiotics In V79 Cells, Gary M. Williams, Klaus D. Brunnemann, Daniel J. Smart, David Molina, Alan M. Jeffrey, Jian-Dong Duan, Niels Krebsfaenger, Andreas Kampkoetter, Gabriele Schmuck

NYMC Faculty Publications

Fluoroquinolone (FQ) antibiotics are bacteriocidal through inhibition of the bacterial gyrase and at sufficient concentrations in vitro, they can inhibit the homologous eukaryotic topoisomerase (TOPO) II enzyme. FQ exert a variety of genotoxic effects in mammalian systems through mechanisms not yet established, but which are postulated to involve inhibition of TOPO II enzymes. To assess the relationship of inhibition of cell nuclear TOPO II to cytotoxicity and reported genotoxicity, two FQ, clinafloxacin (CLFX) and lomefloxacin (LOFX), having available genotoxicity data showing substantial differences with CLFX being more potent than LOFX, were selected for study. The relative inhibitory activities of these …

Faculty Senate Summarized Minutes, 4/23/2013, Unm Faculty Senate

Faculty Senate Meeting Minutes, 1920 - 2013

No abstract provided.

Celebrating Faculty Creative Works 2012, University Of Texas At Arlington Library, Ut Arlington Office Of The Provost

UTA Libraries Staff Publications - Archive

The University of Texas at Arlington Library and the Office of the Provost are pleased to host the fourth Celebration of Faculty Creative Works, an exhibition that showcases the articles, books, art, music, media, patents, and conference activities made by UT Arlington faculty in 2012, as well as outside awards and honors received.

The Effects Of Disaster On Women’S Reproductive Health In Developing Countries, Ronald J. Swatzyna, Vijayan K. Pillai

Social Work Faculty Publications & Presentations-Archive

No abstract provided.

Mek And The Inhibitors: From Bench To Bedside, Akintunde Akinleye, Muhammad Furqan, Nikhil Mukhi, Pavan Ravella, Delong Liu

NYMC Faculty Publications

Four distinct MAP kinase signaling pathways involving 7 MEK enzymes have been identified. MEK1 and MEK2 are the prototype members of MEK family proteins. Several MEK inhibitors are in clinical trials. Trametinib is being evaluated by FDA for the treatment of metastatic melanoma with BRAF V600 mutation. Selumetinib has been studied in combination with docetaxel in phase II randomized trial in previously treated patients with advanced lung cancer. Selumetinib group had better response rate and progression-free survival. This review also summarized new MEK inhibitors in clinical development, including pimasertib, refametinib, PD-0325901, TAK733, MEK162 (ARRY 438162), RO5126766, WX-554, RO4987655 (CH4987655), GDC-0973 …

The Influence Of Faculty Mentors On Junior Pharmacy Faculty Members’ Career Decisions, Nicholas E. Hagemeier, Matthew M. Murawski, Nicholas G. Popovich

ETSU Faculty Works

Objective. To assess junior faculty members’ perceptions regarding the impact of past faculty-mentoring relationships in their career decisions, including the decision to pursue postgraduate training and ultimately an academic career.

Methods. A mixed-mode survey instrument was developed and an invitation to participate in the survey was sent to 2,634 pharmacy faculty members designated as assistant professors in the American Association of Colleges of Pharmacy (AACP) directory data.

Results. Usable responses were received from 1,059 pharmacy faculty members. Approximately 59% of respondents indicated that they had received encouragement from 1 or more faculty mentors that was very or extremely influential in …