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Reconnaissance Investigation Of Soil-Structure Harmonics And Building Collapse Patterns In The 2024 Noto And 2016 Kumamoto Japan Earthquakes, Nathan Cole Chesnut Apr 2025

Reconnaissance Investigation Of Soil-Structure Harmonics And Building Collapse Patterns In The 2024 Noto And 2016 Kumamoto Japan Earthquakes, Nathan Cole Chesnut

Theses and Dissertations

This study used ambient vibration data collected during a reconnaissance mission to assess whether harmonics between structures and the underlying soil played a significant role in the pattern of buildings that collapsed in the magnitude 7.5 Noto Japan earthquake on January 1, 2024, and the magnitude 6.2 to 7.0 Kumamoto Japan earthquake series that occurred between April 14 and 16, 2016. Portable seismometers were used to measure the natural soil and structural frequencies of vibration under ambient loading at sites in Wajima, a city located on the Noto Peninsula, and in four locations in and around Kumamoto City. Soil frequency …


Annual Report 2025, Lindsey Murry, Estevan Garcia Apr 2025

Annual Report 2025, Lindsey Murry, Estevan Garcia

College of Engineering and Science Annual Reports

As we reflect on the past year and look to the future, we are entering a new era for the College of Engineering and Science (COES) — one marked by renewed vision, fresh leadership, and bold ambition.

With the arrival of Dr. Jim Henderson as Louisiana Tech’s newest president, the energy and momentum across our campus is palpable. Here in COES, we are embracing this spirit of progress with open arms. I am honored to serve as the dean of this incredible college, and I’m joined by a dynamic group of new leaders who are ready to shape the future …


Design And Realization Of Concurrent Cryptosystem For Medical Image Privacy On Reconfigurable Hardware, Vinoth Raj R Mar 2025

Design And Realization Of Concurrent Cryptosystem For Medical Image Privacy On Reconfigurable Hardware, Vinoth Raj R

Theses and Dissertations

The protection of medical image privacy plays a crucial role in maintaining confidentiality for the secure storage and transmission of patient’s sensitive healthcare data. Medical images are the widely used data type in the e-healthcare sector. Traditional cryptographic algorithms have limitations when applied to large-scale medical image datasets due to their high computational requirements. The primary goal of this research work is to design and implement indigenous algorithms to provide confidentiality for grayscale and color DICOM (Digital Imaging and Communications in Medicine) images through an encryption process. The research leverages the benefits of reconfigurable hardware, namely the Field-Programmable Gate Arrays …


Comparison Of Milling Cutting Forces In Synthetic And Biological Cancellous Bone, Matthew Christopher Hartwell Jan 2025

Comparison Of Milling Cutting Forces In Synthetic And Biological Cancellous Bone, Matthew Christopher Hartwell

Masters Theses

In many orthopedic and dental interventions, the cutting and removal of bone is necessary. Therefore, it is of the utmost importance that the tools used during these procedures are designed and tested with biological bone or a bone surrogate material that machines the same way as biological bone. To avoid the cost, hazard, and inconsistency of biological cadaveric bone or animal models, many biological engineering firms use bone surrogate material made of glass fiber filled epoxy and polyurethane foam. Although these materials may mimic the elongation of cortical and cancellous bone, respectively, the match of machinability of the bone is …


Taking The Leap: A Qualitative Study Exploring The Entanglement Of The Vertical Transfer Process And Engineering Identity Development Among Community College Students, Janice Edwards Jan 2025

Taking The Leap: A Qualitative Study Exploring The Entanglement Of The Vertical Transfer Process And Engineering Identity Development Among Community College Students, Janice Edwards

Dissertations of Practice

Taking the Leap: A Qualitative Study Exploring the Entanglement of the Vertical Transfer Process and Engineering Identity Development among Community College Students

Community colleges provide an open access, cost effective pathway to earning a baccalaureate degree in engineering. However, the transfer and degree completion rates remain low. Improved persistence has been linked to a variety of factors including a strong engineering identity. The purpose of this qualitative case study was to expand the understanding of engineering identity development during the vertical transfer process. Each milestone in the process, framed within transfer student capital, was considered to determine what, if any, …


Voltage-Dependent Anion-Selective Channels 1 And 2 Wild Type And Mutant Bh3-Like Domain Peptides: Analysis Of Secondary Structure And Binding Stoichiometry To Recombinant Bax, Geanell C. Adams Jan 2025

Voltage-Dependent Anion-Selective Channels 1 And 2 Wild Type And Mutant Bh3-Like Domain Peptides: Analysis Of Secondary Structure And Binding Stoichiometry To Recombinant Bax, Geanell C. Adams

Electronic Theses and Dissertations

Despite national efforts to increase female participation in science, technology, engineering, and mathematics (STEM), women remain significantly underrepresented in collegiate STEM programs. This pilot study sought to identify pre-collegiate factors that influence female students’ decisions to enroll and persist in STEM collegiate programs at the University of Mississippi, a predominantly white R1 research institution using qualitative methods. Grounded in Bandura’s Social Learning Theory, the research examined the environmental, behavioral, and personal determinants that shape academic pathways for women in STEM.

Data were collected through semi-structured interviews with six sophomore female STEM majors. Thematic analysis revealed that early exposure to structured …


Characterization Of Turbulent Flames In Confined Combustors, Max Fortin Jan 2025

Characterization Of Turbulent Flames In Confined Combustors, Max Fortin

Graduate Thesis and Dissertation post-2024

As industry transitions to a net-zero carbon future, turbulent premixed combustion will remain an integral process for power generating gas turbines and are also desired for aviation engines due to their ability to minimize pollutant emissions. However, accurately predicting the behavior of a turbulent reacting flow field remains a challenge. To better understand the dynamics of premixed reacting flows, this study experimentally investigates the evolution of turbulence in a high-speed bluff-body combustor. The combustor operates across a range of equivalence ratios from 0.7-1 to quantify the role of heat release and flame scales on the evolution of turbulence as the …


Educational Experiences Of Latinas In Space Exploration: Achievement Motivation And Science Identity Development, Roslyn Soto Sanchez Jan 2025

Educational Experiences Of Latinas In Space Exploration: Achievement Motivation And Science Identity Development, Roslyn Soto Sanchez

CGU Theses & Dissertations

For the U.S. to retain a leading role in understanding the solar system and the universe, a diverse and highly skilled STEM workforce is required. This qualitative study of the K-12 and higher education lived experiences of 30 Latinas who have earned STEM degrees and work in space exploration contributes to existing research by (a) offering insight on the types of achievement motivation that drives them to succeed along these challenging academic pathways; (b) providing an understanding of how Latinas in space exploration developed their science identities, and at what point they felt like they belonged as “real” scientists, engineers …


Development And Evaluation Of Machine Learning Models For Early Pediatric Sepsis Prediction, Ancita M. Andrade Jan 2025

Development And Evaluation Of Machine Learning Models For Early Pediatric Sepsis Prediction, Ancita M. Andrade

Browse all Theses and Dissertations

Sepsis is a leading cause of pediatric mortality, claiming more lives in the United States annually than all childhood cancers combined. Early identification in Emergency Departments (EDs) remains challenging, as the current Phoenix criteria establishes an updated international consensus definition for sepsis, however is not designed for use as a screening tool. This study aimed to develop predictive models identifying pediatric patients at risk of sepsis within 24 hours of admission. Multiple tree-based and deep learning models were trained utilizing clinical and laboratory data from the initial four hours of presentation. Both the LightGBM and LSTM architectures demonstrated superior performance, …


Cellular Mechanisms Of Spinal Motoneuron Hypoexcitability Underlying Dynapenia In Aging, Ibrahim Abdul Halim Jan 2025

Cellular Mechanisms Of Spinal Motoneuron Hypoexcitability Underlying Dynapenia In Aging, Ibrahim Abdul Halim

Browse all Theses and Dissertations

Age-related weakness remains poorly understood as the underlying mechanisms remain unclear. While synaptic input and muscular changes have been investigated with age, intrinsic motoneuron excitability alterations are often overlooked. This thesis provides the first direct assessment of intrinsic excitability and ion channel properties of spinal α-MNs from male and female mice across three ages: young, middle aged, and old. Our findings reveal a decline in intrinsic excitability of motoneurons with age in both sexes. Mechanistic analysis shows sex specific differences: female motoneurons exhibit increased dendritic size, hyperpolarized RMP, and SK channel overactivation, whereas males show only SK overactivation with age. …


Wearable Sensor Data Analysis For Machine Learning-Based Detection Of Posture And Autonomic Responses, Chaitanya Vardhini Anumula Jan 2025

Wearable Sensor Data Analysis For Machine Learning-Based Detection Of Posture And Autonomic Responses, Chaitanya Vardhini Anumula

Browse all Theses and Dissertations

This study investigates how Iyengar yoga postures influence autonomic nervous system (ANS) activity by analyzing multimodal physiological signals collected via wearable sensors. The physiological mechanisms underlying Iyengar yoga’s therapeutic effects remain under-explored at the granular, pose-level. Using data collected from 16 participants, this research evaluates whether machine learning models can distinguish between baseline, parasympathetic-dominant, and sympathetic-dominant states based on wrist-worn sensor data. The goals were to explore whether subtle postural variations elicit measurable autonomic responses and to identify which sensor features most effectively capture these changes. Participants performed a sequence of yoga poses while wearing synchronized sensors measuring electrodermal activity …


Impact Of Graph Structures For Rag Outcomes In Llms, Chris Davis Jaldi Jan 2025

Impact Of Graph Structures For Rag Outcomes In Llms, Chris Davis Jaldi

Browse all Theses and Dissertations

Explainability, interpretability and adaptability (EIA) remain three central motivations for next-generation Artificial Intelligence (AI), especially as Large Language Models (LLMs) continue to engage with ever-increasing knowledge bodies. As the landscape pushes toward controllable agentic Retrieval-Augmented Generation (RAG) systems where AI agents engage in iterative, guided reasoning, a critical question arises as to the extent to which the knowledge design itself shapes these models' reasoning behavior. This work conducts a systematic evaluation of how different conceptualizations and representation of the identical knowledge affect an LLM's path-based reasoning capabilities. Through the introduction of controlled variations along graph structural complexity, linguistic and semantic …


Re-Parameterizing Adversarial Reprogramming In Low-Dimensional Subspace For Efficient Software Vulnerability Detection, Hootan Alavizadeh Jan 2025

Re-Parameterizing Adversarial Reprogramming In Low-Dimensional Subspace For Efficient Software Vulnerability Detection, Hootan Alavizadeh

Browse all Theses and Dissertations

Software vulnerabilities are a major cause of security breaches, making effective detection critical. Traditional learning-based methods require large datasets and significant computational resources, which are often impractical due to high annotation costs and data scarcity. To address this, we propose an innovative system, RearVul, which Re-parameterizes adversarial reprogramming in a low-dimensional subspace for software vulnerability detection. Unlike conventional approaches, RearVul repurposes a pre-trained classification model using adversarial reprogramming, enabling detection with minimal modifications. It learns a universal perturbation applied to program representations, preserving the original model’s feature extraction capabilities while adapting it to a new domain. Furthermore, we introduce a …


Subjective Readiness Forecasting Using Supervised Machine Learning And Wearable Device Data, Nathaniel Michael Weiland Jan 2025

Subjective Readiness Forecasting Using Supervised Machine Learning And Wearable Device Data, Nathaniel Michael Weiland

Browse all Theses and Dissertations

Recent advances in wearable technology allow continuous monitoring of physiological and behavioral data, opening new opportunities for real-time assessments of readiness and well-being. However, creating predictive models that generalize across diverse users remains challenging, especially in high-stakes settings like the military, where preventable injuries, illnesses, and stress-related performance declines are frequent. This research assesses the feasibility of using supervised machine learning models trained on wearable device data to predict subjective readiness indicators—recovery, stress, injury, and illness. Data from over 10,000 users in the OHWS (Optimizing the Human Weapons System) program combined daily check ins with physiological metrics from Garmin, Polar, …


Computational Assessment Of Vitrimers Self-Healing For Renewable Energy And Aerospace Structures, Walaaeldin Mohamed Ahmed Derbala Jan 2025

Computational Assessment Of Vitrimers Self-Healing For Renewable Energy And Aerospace Structures, Walaaeldin Mohamed Ahmed Derbala

Browse all Theses and Dissertations

Self-healing polymers, particularly vitrimers, are emerging as promising candidates in the development of advanced materials for renewable energy and aerospace structures. These materials exhibit dynamic covalent bond exchange mechanisms that enable reprocess ability, damage repair, and extended operational lifetime under harsh conditions. This study presents a density functional theory (DFT)-based computational investigation of the mechanistic pathways and energetics of bond exchange reactions in model vitrimer systems. We explore transition states, energy barriers, and thermodynamic features corresponding to associative and dissociative self-healing reactions in vitrimers. The study focuses on Diaminodiphenyl disulfide (AFD), a bifunctional molecule composed of two para-substituted aminophenyl rings …


Ab Initio Simulations For Oxidation Of An Ultra-High Temperature Ceramic (Hfb2), Wesley I. Black Jan 2025

Ab Initio Simulations For Oxidation Of An Ultra-High Temperature Ceramic (Hfb2), Wesley I. Black

Browse all Theses and Dissertations

Ultra-High Temperature Ceramics are a class of ceramics that possess high strength and melting points in excess of 3000°C. These ceramics are promising for aerospace applications, where materials need to endure high-temperature and high-stress environments. Utilizing ab initio simulations, this thesis research focuses on the atomistic details of oxidation for a typical ultra-high temperature ceramic material, namely hafnium diboride. The simulations provide energy barriers for transition from the initial to final structures via transition states on the (0 0 0 1) surface. These result in estimates for reaction rates and other thermodynamic features that are essential for assessing applicability under …


Reinforcement Learning For Adversarial Environments: Multi-Agent Hide And Seek With Multi-Modal Sensing, Christian Alejandro Carrizales Jan 2025

Reinforcement Learning For Adversarial Environments: Multi-Agent Hide And Seek With Multi-Modal Sensing, Christian Alejandro Carrizales

Browse all Theses and Dissertations

The development of intelligent and competitive agents in AI versus AI adversarial environments was explored through the utilization of reinforcement learning techniques with sensing modalities. A Hide-and-Seek simulation environment was developed using the Unity game engine along with the ML-Agents Toolkit. An engagement test campaign with a set of performance metrics was designed. Four AI versus AI adversarial scenarios were considered using the Proximal Policy Optimization (PPO) and Soft Actor-Critic (SAC) multi-agent reinforcement learning algorithms. Furthermore, the impact of sensing modalities on competing agents’ learning performance was investigated by varying the sensing capabilities of the hider and seeker, respectively. Experiments …


Dataset Generation For Routing Policy Study In Ad Hoc Wireless Networks, Vishnu Vishnu Priya Jan 2025

Dataset Generation For Routing Policy Study In Ad Hoc Wireless Networks, Vishnu Vishnu Priya

Browse all Theses and Dissertations

Ad Hoc wireless networks, with their decentralized architecture and dynamic topology, present challenges in reliable and energy-efficient routing. While machine learning (ML) and reinforcement learning (RL) offer promising solutions, progress is limited by the lack of realistic, high-fidelity datasets. This research introduces a simulation-based framework for generating four diverse datasets representing combinations of node mobility (mobile vs. static) and spatial distribution (random vs. clustered). Each dataset captures critical metrics such as Signal-to-Interference-plus-Noise Ratio (SINR), bottleneck rate, and power consumption across multi-hop paths. A lookahead-based greedy routing algorithm with scenario-aware power control is implemented to emulate practical behavior. Supervised ML models, …


Isometric Centroid Encoder (Ice) And Synthetic Data Generation Approaches For Biological Datasets, Prathyusha Kanakamalla Jan 2025

Isometric Centroid Encoder (Ice) And Synthetic Data Generation Approaches For Biological Datasets, Prathyusha Kanakamalla

Browse all Theses and Dissertations

This thesis addressed two main challenges in biological data analysis: structure-preserving dimensionality reduction and synthetic data generation for small sample datasets. I proposed the Isometric Centroid Encoder (ICE), a supervised dimensionality reduction method that preserves pairwise distances between class centroids during dimension reduction. Unlike existing methods like Centroid Encoder and Super Encoder, ICE explicitly maintains geometric relationships between biological classes, achieving nearly perfect structure preservation at C dimensions (where C equals the number of classes) with strong performance even in 2D and 3D spaces. Additionally, I compared three generative models (VAE, LSH-GAN, and scDiffusion) for synthetic data generation on small …


Hydrogen Storage Density And Adsorption Energy Barriers On Li-Decorated Bc3 Nanosheet, Sri Venkat Pavan Upasi Jan 2025

Hydrogen Storage Density And Adsorption Energy Barriers On Li-Decorated Bc3 Nanosheet, Sri Venkat Pavan Upasi

Browse all Theses and Dissertations

Hydrogen is considered an emerging carrier of clean energy with renewable capabilities. Widespread hydrogen energy utilization necessitates efficient storage strategies. Functionalized nanomaterials, such as Li-decorated BC3 nanosheets, are among the primary candidate materials for hydrogen storage. This research investigates the feasibility of hydrogen storage by estimating energy barriers and their dependence on storage density on Li-decorated BC3 nanosheet. Density functional theory (DFT) simulations provide estimates of adsorption energies and saddle points for hydrogen storage and compare corresponding reaction rates. The results are expected to help us understand the advantages and possible shortcomings of hydrogen storage on such nanomaterials.


Leveraging Counterfactuals For Enhanced Natural Language Inference: A Multitask Knowledge Distillation Approach, Brian J. Davis Jan 2025

Leveraging Counterfactuals For Enhanced Natural Language Inference: A Multitask Knowledge Distillation Approach, Brian J. Davis

Browse all Theses and Dissertations

Natural-language inference (NLI) asks whether a hypothesis is entailed by, contradicts, or is neutral with respect to a premise. Modern transformers reach high raw accuracy on benchmarks such as SNLI, MNLI, and ANLI, yet they often rely on brittle lexical shortcuts and provide little insight into their decision process. This thesis shows that counterfactual-augmented knowledge distillation can simultaneously boost robustness and supply faithful, token-level explanations—without scaling model size. Four T5-v1_1 students (60M, 220M, 770M, 3B parameters) are trained under four curricula: (1) standard fine-tuning, (2) fine-tuning with free-text rationales, (3) multi-task distillation with naive counterfactuals, and (4) multi-task distillation with …


Optimizing Cloud Computing Resources For Operational Cost And Application Performance Using Machine Learning, Isaac K. Matthew Jan 2025

Optimizing Cloud Computing Resources For Operational Cost And Application Performance Using Machine Learning, Isaac K. Matthew

Browse all Theses and Dissertations

As AI-driven workloads accelerate the growth of cloud initiatives and spending, resource waste also increases due to persistent inefficiencies in cloud compute and infrastructure management. Overprovisioned resources and suboptimal configurations often lead to operational inefficiencies and unnecessary financial overhead. These challenges arise from the difficulty of anticipating resource demands in dynamic workloads and selecting suitable virtual machines to ensure optimal performance. Our research proposes a holistic, data-driven framework for managing cloud compute resources that reduces costs without compromising application performance. We integrate a predictive, model-driven, threshold-based autoscaling solution for cloud-native applications with an optimized instance right-sizing approach to select cost-effective …


Reducing Operator Training Time Through Virtual Reality: A Case Study On The Lpkf Protomat E44 Machine, Joshua C. Patel Jan 2025

Reducing Operator Training Time Through Virtual Reality: A Case Study On The Lpkf Protomat E44 Machine, Joshua C. Patel

Browse all Theses and Dissertations

This thesis presents the development of an immersive virtual reality (VR) simulation that replicates the operation of the LPKF ProtoMat E44 PCB milling machine. Aimed at reducing operator training time and improving procedural understanding, the simulation offers an interactive and realistic environment where users can safely engage with machine workflows and start-up sequences. The emphasis is on accurate representation, usability, and maintaining immersion to support intuitive learning. Although formal evaluation is outside the scope of this work, the system is designed to serve as a foundation for cost-effective, scalable training in technical and manufacturing contexts, offering a modern alternative to …


Scalable Real-Time Stream Clustering For Unbounded Text Streams, Nathaniel C. Crossman Jan 2025

Scalable Real-Time Stream Clustering For Unbounded Text Streams, Nathaniel C. Crossman

Browse all Theses and Dissertations

Social media, AI systems, IoT sensors, and other platforms generate vast amounts of streaming data. Given this vast volume of information, techniques that can reduce and aggregate data into meaningful topics are essential. One such technique is the two-phase stream clustering approach. In the first, online micro-clustering phase, the system forms micro-clusters from the incoming data stream, incrementally merges new items into related existing micro-clusters, and prunes or fades micro-clusters as they become inactive, producing a constantly updating yet compact set of micro-clusters representing potential topics and subtopics of the stream. In the second, offline macro-clustering phase, these micro-clusters are …


Patient Subset Classification Using Encoded Embeddings And Knowledge Graph Retrieval-Augmented Generation, Benjamin A. Holmes Jan 2025

Patient Subset Classification Using Encoded Embeddings And Knowledge Graph Retrieval-Augmented Generation, Benjamin A. Holmes

Browse all Theses and Dissertations

The widespread adoption of electronic medical records has created a vast reservoir of clinical data that can be leveraged to better understand how interventions relate to patient outcomes. Much of this information, however, exists as unstructured free-text, posing significant challenges for traditional statistical and machine-learning methods. Solving these challenges would allow the extraction of specific patient subpopulations (clinically relevant cohorts of individuals who share overlapping symptoms, risk factors, or diagnostic criteria), which could be used in precision medicine. Despite this promise, extracting these subpopulations from unstructured medical notes is an ongoing challenge due to the variability of clinical language and …


Quantification Of Porosity In Hfb2–20%Sic Using Convolutional Neural Networks, Cameron J. Floyd Jan 2025

Quantification Of Porosity In Hfb2–20%Sic Using Convolutional Neural Networks, Cameron J. Floyd

Browse all Theses and Dissertations

Ultra-high-temperature ceramics, commonly used in aerospace applications, operate in high-temperature oxidizing environments where a surface scale forms and regulates oxy gen access. For hafnium diboride–silicon carbide (HfB2–SiC), that scale consists of a borosilicate glass layer over a porous HfO2 skeleton. Oxygen transport through this poros ity governs the kinetics of mechanistic models, requiring reproducible inputs for accurate pore fraction (PF), pore-size distributions, and ultimately tortuosity. This thesis replaces rule-based SEM thresholding with a convolutional neural network that segments pores and predicts the pore-radius distribution for transport models. The resulting calibrated porosity maps and size distributions transfer within the acquisition domain …


Generative Adversarial Networks (Gans) For High-Dimensional Biological Data, Harigovind Harikumar Jan 2025

Generative Adversarial Networks (Gans) For High-Dimensional Biological Data, Harigovind Harikumar

Browse all Theses and Dissertations

This thesis investigates the application of Generative AI models, mainly Generative Adversarial Network (GAN) models to high dimensional and low sample size biological datasets like Motion Sickness, Breast Cancer, Crohn, and Melanoma. We utilized and compared three generative AI frameworks: Vanilla GAN, Wasserstein GAN (WGAN), Locality-Sensitive Hashing GAN (LSH-GAN) and Omics GAN. To address the challenges associated with high-dimensionality and low sample size, which was leading to very poor outputs of biological synthetic samples, we came up with an approach to stop the model when it reaches its saturation level. That is, we printed the loss plots to see where …


Pixmix Attack: Implementation And Evaluation Of A Novel Pixel Injection On Digital Video Port (Dvp) Interface In Embedded Camera Systems With Pcb Hardware Trojan, Sayed Md Tashfi Nowroz Jan 2025

Pixmix Attack: Implementation And Evaluation Of A Novel Pixel Injection On Digital Video Port (Dvp) Interface In Embedded Camera Systems With Pcb Hardware Trojan, Sayed Md Tashfi Nowroz

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Image sensors are at the heart of machine vision systems in robotics, industrial automation, and surveillance systems which ideally operate with minimal human supervision and only occasional maintenance. The image sensors convert visible light into electrical signals which are locally decoded to image on the printed circuit board (PCB) by an ordinary embedded processor System on Chip (SoC). This thesis investigates a critical vulnerability in such systems, targeting the communication protocol at the signal level during runtime. Specifically, it focuses on a novel attack in the Digital Video Port (DVP) protocol, possible to exploit with PCB-based hardware Trojans, to craft …


A Secure Ml-Assisted Framework For Resilient And Efficient Prediction Of Physiotherapy Sequence In Bilateral Carpal Tunnel Syndrome, Pratik Pandurang Kharat Jan 2025

A Secure Ml-Assisted Framework For Resilient And Efficient Prediction Of Physiotherapy Sequence In Bilateral Carpal Tunnel Syndrome, Pratik Pandurang Kharat

Browse all Theses and Dissertations

Bilateral idiopathic carpal tunnel syndrome (CTS) is a neuromuscular disorder characterized by compression of the median nerve at both wrists, leading to symptoms such as pain, numbness, tingling, and muscle weakness. Unlike unilateral cases, bilateral idiopathic CTS presents distinct therapeutic challenges due to the simultaneous involvement of both hands and the lack of an identifiable underlying cause. This study explores the application of machine learning techniques to predict the optimal sequence of physiotherapeutic interventions Stretching followed by Myofascial Mobilization (S/M) or the reverse (M/S) in female patients with bilateral idiopathic CTS and right hand dominance. Data were drawn from a …


The Impact Of Ahr And Hs1.2 Enhancer Genetic Variations On Igh Expression And Antibody Production In Human B Cells, Mili Santosh Bhakta-Yadav Jan 2025

The Impact Of Ahr And Hs1.2 Enhancer Genetic Variations On Igh Expression And Antibody Production In Human B Cells, Mili Santosh Bhakta-Yadav

Browse all Theses and Dissertations

Antibody production is an essential component of the immune response against pathogens. The immunoglobulin heavy chain (IgH) gene codes for the heavy chain of antibodies. The IgH constant regions Cμ, Cδ, Cγ1-4, Cα1-2, and Cε encode the five major classes of antibodies, i.e., IgM, IgD, IgG1-4, IgA1-2, and IgE, respectively. The transcription of the IgH gene and class switch from IgM to other isotypes is regulated by two 3’ IgH regulatory regions (3’IgHRRs), each of which is a cluster of three enhancer regions (hs3, hs1.2 and hs4). The genetic variations in the hs1.2 enhancer have been identified; a ~53 bp …