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The Role Of Nutrition And Hormone Signaling In Extended Larval Development And Obesity In Starvation-Selected Drosophila Melanogaster, Jennifer M. Clark May 2021

The Role Of Nutrition And Hormone Signaling In Extended Larval Development And Obesity In Starvation-Selected Drosophila Melanogaster, Jennifer M. Clark

UNLV Theses, Dissertations, Professional Papers, and Capstones

Brief periods of starvation are a common stressor that most animals encounter in the wild and must be able to survive in order to maximize their fitness. Starvation resistance of the adult fruit fly, Drosophila melanogaster, is thought to be primarily conferred by adult fat stores, body size, metabolic rate, behavior, and activity levels. Additionally, flies selected for starvation resistance also often show delayed pupariation, which is usually indicative of altered hormone signaling. How starvation selection extends development and if it contributes to adult starvation resistance remains incompletely studied. Identifying the targets of starvation selection that cause extended development and …


College Students' Knowledge Of The Relationship Between Diet And Facial Acne, Caroline Moulton May 2021

College Students' Knowledge Of The Relationship Between Diet And Facial Acne, Caroline Moulton

Honors Theses

A common struggle for many young adults is the infamous acne vulgaris. Americans spend millions of dollars on acne medication, treatments, and dermatology and cosmetic visits each year. One area that is greatly lacking in research is the relation of nutrition and facial skin appearance. In clinical settings this topic is not commonly discussed, but evidence shows diet changes could greatly benefit those struggling with acne. The present study sought to investigate the knowledge of college students regarding various food and beverage items and facial skin appearance by electronically distributing a self-report survey to a sample of 385 college students …


Should I Reduce My Red Meat Consumption?, Joshua Kojiro Bibbee May 2021

Should I Reduce My Red Meat Consumption?, Joshua Kojiro Bibbee

Capstone Projects and Master's Theses

Maintaining and improving the health of 5,000+ county employees is no easy task, but the Monterey County Health Department Employee Wellness (MCHDEW) program’s job is to do just that. There are many parts that fall under the category of health, and one area to research on is red meat consumption. A diet high in red meat can cause some of the health conditions of metabolic syndrome, which is a cluster of health conditions that increase a person’s risk of heart disease. This is relevant because metabolic syndrome is found in one-third of county employees, and this contributes to increased healthcare …


Dietary Factors And Gastric Intestinal Metaplasia Risk Among Us Veterans, Mimi C Tan, Niharika Mallepally, Quynh Ho, Yan Liu, Hashem B El-Serag, Aaron P Thrift May 2021

Dietary Factors And Gastric Intestinal Metaplasia Risk Among Us Veterans, Mimi C Tan, Niharika Mallepally, Quynh Ho, Yan Liu, Hashem B El-Serag, Aaron P Thrift

Faculty, Staff and Students Publications

BACKGROUND: Studies on diet and gastric intestinal metaplasia (GIM) risk are lacking in US populations.

AIM: To determine the associations of dietary factors and risk of GIM among a US population with typical American diet.

METHODS: We analyzed data from a cross-sectional study of veterans attending primary care and endoscopy clinics at the Houston VA Medical Center. Patients completed a 110-item Block Food Frequency Questionnaire then underwent upper endoscopy with gastric mapping biopsies. We compared cases defined by GIM on ≥ 1 non-cardia gastric biopsy to controls without GIM. Associations of dietary factors and GIM were estimated using logistic regression …


Perivascular Adipose Tissue In Relation To Diet, Thermogenesis And Cardiovascular Health, Ginger Paquette, Caitlin Stieber, Ashely Soucy, Benjamin Tero, Lucy Liaw Apr 2021

Perivascular Adipose Tissue In Relation To Diet, Thermogenesis And Cardiovascular Health, Ginger Paquette, Caitlin Stieber, Ashely Soucy, Benjamin Tero, Lucy Liaw

Thinking Matters Symposium

Adipose tissue is a diverse and crucial component to vascular health due to its role in energy storage and heat production. The primary function of white adipose tissue (WAT) is energy storage while the function of mitochondria-rich brown adipose tissue (BAT) is heat production. Perivascular adipose tissue (PVAT), which surrounds blood vessels, contains both WAT and BAT adipocytes. Dietary calorie restriction is associated with increased lifespan with decreased adiposity. Increased prevalence of WAT-like PVAT, due to high-fat diets and obesity, leads to increased metabolic disfunction and cardiovascular-disease. We used a calorie-restriction model in C57BL6/J mice to test the hypothesis that …


A Review: Composition Of Neonatal Meconium Microbiota And Its Role For Potential Probiotic, Devi Oktaviyani, Raden Zulfa 'Alawiyyah, Putri Nusaiba, Amarila Malik Apr 2021

A Review: Composition Of Neonatal Meconium Microbiota And Its Role For Potential Probiotic, Devi Oktaviyani, Raden Zulfa 'Alawiyyah, Putri Nusaiba, Amarila Malik

Pharmaceutical Sciences and Research

Early-life period (≤ 1 month after birth) is critical for determining long- and short-term health of neonates. Composition of neonates’ gut microbiota varies greatly between individuals whose development is influenced by various factors including differences in maternal diet and lifestyle during pregnancy, related to population and ethnicity. Balanced microbial composition can create symbiosis among commensal microbes, immunomodulatory compound production, and subsequent immune response regulation. Unbalanced microbiota composition, characterized by more pathogenic organism, less diversity, and less resistance to disease, is called dysbiosis. Probiotic bacteria are a bacteria group contributing to the balance of neonates’ gut microbiota. Probiotic bacterial strains, such …


Bed And Breakfast: The Role Of Sleep In Breakfast Intake, Ashley R. Macpherson, Natalie D. Dautovich Apr 2021

Bed And Breakfast: The Role Of Sleep In Breakfast Intake, Ashley R. Macpherson, Natalie D. Dautovich

Journal of Social, Behavioral, and Health Sciences

Breakfast intake is associated with numerous positive physical and mental health outcomes, yet skipping breakfast remains common in adults. Sleep behaviors show potential as predictors of breakfast intake; the existing literature, however, has methodological limitations. The current investigation explored the association of means and intraindividual variability of a variety of sleep behaviors (bedtime, midsleep, sleep duration) as predictors of the frequency of eating breakfast and frequency of high-protein breakfast intake. Hierarchical regressions were conducted to assess direct associations between sleep behaviors and breakfast intake frequency. Variability in bedtime was a significant predictor of the frequency of breakfast intake, with greater …


Type 2 Diabetes - A Change For A Better Life, Hilary Greene Apr 2021

Type 2 Diabetes - A Change For A Better Life, Hilary Greene

MSN Capstone Projects

Cardiovascular disease has been known to be the leading cause of mortality in patients with type 2 diabetes. With diabetes on the rise in the United States, it is important to assess changes in these patients to decrease the risk of developing cardiovascular disease or a major cardiovascular event such as a myocardial infarction, stroke, or death. If able to address healthy alternatives to patients to reduce the risks of major cardiovascular events such as a myocardial infarction or stroke, it could potentially save many lives. As a nurse educator, it is important to provide patients with the education they …


Best Practices To Prevent Or Delay Diabetes In Adults With Prediabetes, Aminata Cham Apr 2021

Best Practices To Prevent Or Delay Diabetes In Adults With Prediabetes, Aminata Cham

Nursing DNP Projects

Abstract

Diabetes mellitus is a common disease prevalent in 10.5% of the US population about 34.2 million people and a disproportionate percentage of people of color. An EBP project for people with prediabetes was conducted in a faith-based based setting after institutional review board approval. The purpose of the project was to increase fruits and vegetable intake and increase physical activity in adults with prediabetes. The Chronic Care Model was used to guide the design and implementation of the project. The project was a modified version of the National Diabetes Prevention Program (NDPP) in a series of four 2-hour sessions …


Change In Dietary Inflammatory Index Score Is Associated With Control Of Long-Term Rheumatoid Arthritis Disease Activity In A Japanese Cohort: The Tomorrow Study, Yoshinari Matsumoto, Nitin Shivappa Mbbs, Mph, Ph.D., Yuko Sugioka, Masahiro Tada, Tadashi Okano, Kenji Mamoto, Kentaro Inui, Daiki Habu, James R. Hébert Scd, Tatsuya Koike Apr 2021

Change In Dietary Inflammatory Index Score Is Associated With Control Of Long-Term Rheumatoid Arthritis Disease Activity In A Japanese Cohort: The Tomorrow Study, Yoshinari Matsumoto, Nitin Shivappa Mbbs, Mph, Ph.D., Yuko Sugioka, Masahiro Tada, Tadashi Okano, Kenji Mamoto, Kentaro Inui, Daiki Habu, James R. Hébert Scd, Tatsuya Koike

Faculty Publications

Background: The dietary inflammatory index (DII®), a quantitative measure of the inflammatory potential of daily food and nutrient intake, and associations between a variety of health outcomes have been reported. However, the association between DII score and disease activity of rheumatoid arthritis (RA) is unclear. Therefore, this study was designed to test whether higher DII score contributes to disease activity and as a corollary, y, whether reducing DII score helps to achieve or maintain low disease activity or remission in patients with RA.

Methods: We performed a cross-sectional and longitudinal analysis using 6 years of data (from 2011 to 2017) …


Dietary Intake Is Associated With Neuropsychological Impairment In Women With Hiv, Leah H. Rubin, Deborah R. Gustafson, Lakshmi Warrior, Lila Sheira, Kathryn C. Fitzgerald, Raha Dastgheyb, Kathleen M. Weber, Phyllis C. Tien, Audrey French, Amanda B. Spence, Anjali Sharma, Dionna W. Williams, Cory J. White, Eric C. Seaberg, Edward A. Frongillo Jr., Sheri D. Weiser Apr 2021

Dietary Intake Is Associated With Neuropsychological Impairment In Women With Hiv, Leah H. Rubin, Deborah R. Gustafson, Lakshmi Warrior, Lila Sheira, Kathryn C. Fitzgerald, Raha Dastgheyb, Kathleen M. Weber, Phyllis C. Tien, Audrey French, Amanda B. Spence, Anjali Sharma, Dionna W. Williams, Cory J. White, Eric C. Seaberg, Edward A. Frongillo Jr., Sheri D. Weiser

Faculty Publications

Background

Diet is a modifiable risk factor that may influence cognition in people with HIV.

Objectives

We examined the association between dietary intake and cognition in women with HIV (WWH) and HIV-seronegative women.

Methods

An 18-item dietary National Cancer Institute screener was completed by 729 WWH and 346 HIV-seronegative Women's Interagency HIV Study participants. Daily intake frequencies of processed meats, sweet beverages, fish, whole milk, and vegetables were calculated. Participants completed biennial neuropsychological (NP) testing. NP domains included attention/working memory, executive function, processing speed, memory, learning, fluency, and motor function. NP impairment was defined as demographically adjusted T-scores (mean = …


The Gut Microbiome, Lucy Patterson Mar 2021

The Gut Microbiome, Lucy Patterson

Osmosis Magazine

The gut microbiome is characterized as living microorganisms, including bacteria and viruses, and genetic material found within the gastrointestinal (GI) tract. These microorganisms aid in the digestion and absorption of nutrients in food, and play an active role in the digestive process. However, recent evidence suggests that the gut microbiome is not only helpful in the digestion of food, but also could be linked to mental health and personality.


Milk-Fat Intake And Differences In Abdominal Adiposity And Bmi: Evidence Based On 13,544 Randomly Selected Adults, Klarissa Rae Wilkinson Mar 2021

Milk-Fat Intake And Differences In Abdominal Adiposity And Bmi: Evidence Based On 13,544 Randomly Selected Adults, Klarissa Rae Wilkinson

Theses and Dissertations

The primary objective of this study was to evaluate the relationship between milk-fat intake and obesity, particularly abdominal obesity, in 13,544 U.S. adults. A secondary objective was to determine the extent to which the association was influenced by multiple potential confounding variables. This cross-sectional study used data from the 2011–2016 National Health and Nutrition Examination Survey (NHANES). Level of milk-fat content regularly consumed was the exposure variable. Body mass index (BMI) and sagittal abdominal diameter (SAD), a measure of abdominal obesity, were the outcome variables. SAD correlates strongly with visceral fat, when measured by computed tomography, and has been shown …


Lymphangiography With Lipiodol As A Diagnostic And Therapeutic Approach For Chyle Leak Ascites Following Simultaneous Pancreas-Kidney Transplant, Atta Nawabi, Adam C. Kahle, Perel Baral, Clay D. King, Perwaiz Nawabi Mar 2021

Lymphangiography With Lipiodol As A Diagnostic And Therapeutic Approach For Chyle Leak Ascites Following Simultaneous Pancreas-Kidney Transplant, Atta Nawabi, Adam C. Kahle, Perel Baral, Clay D. King, Perwaiz Nawabi

Student Publications

Chylous ascites (CA) is the leakage of triglyceride-rich fluid into the peritoneal cavity. This most commonly occurs due to trauma of the lymphatic system. Recently, lymphangiography with lipiodol have been used with promising results in managing refractory postoperative CA. We present the case of a 35-year-old man who developed massive refractory CA post simultaneous pancreas-kidney (SPK) transplant. After conservative management with diet modifications failed, the patient underwent lymphangiography and lymph angioembolization using lipiodol. In this case report, we describe the use of lymphangiography as both a diagnostic and therapeutic approach to successfully manage large volume CA following SPK.


Parents’ Perception Of Their Preschool Children’S Weight Status And Diet Quality: How Accurate It Is?, Taraneh Hazhin Mar 2021

Parents’ Perception Of Their Preschool Children’S Weight Status And Diet Quality: How Accurate It Is?, Taraneh Hazhin

Seton Hall University Dissertations and Theses (ETDs)

Childhood obesity is a major public health problem. Parents often have an inaccurate perception of their child’s weight status and diet quality. The purpose of this study was to assess the accuracy of parents’ perception of their 3-5 years old children’s weight status and diet quality; and to explore if there was a relationship between parental weight perception, parental diet perception, and children’s diet quality. A cross-sectional survey design was used to collect data from parents of healthy 3-5 years old preschool children (n=333) through convenient sampling method. Parents’ perception of their preschool children’s weight status was measured using a …


Impact Of A Summer Nutrition And Physical Activity Intervention To Attenuate Obesity In Urban African-American Youth, Jermaine B. Mitchell, Antonio J. Gardner, Zachary Wahl-Alexander, Ben Schwamberger, Douglas Craddock Jr., Carol N. Agomo, Myia C. Lang Mar 2021

Impact Of A Summer Nutrition And Physical Activity Intervention To Attenuate Obesity In Urban African-American Youth, Jermaine B. Mitchell, Antonio J. Gardner, Zachary Wahl-Alexander, Ben Schwamberger, Douglas Craddock Jr., Carol N. Agomo, Myia C. Lang

International Journal of Aquatic Research and Education

Improved eating behaviors and daily participation in physical activity such as swimming might abate the likelihood of African American youth becoming obese. Yet many African American youth neither consume the recommended daily servings of nutritious foods nor know how to swim. The purpose of this study was to investigate the impact of a culturally tailored multicomponent summer intervention to reduce obesity and unintentional drownings among underserved African American youth. Children (n = 145) participated in a three-hour, community-based intervention for four weeks. Measures of children’s attitudes perceived behavioral control, and subjective norms toward swimming, nutrition, and physical fitness were …


Associations Between Dietary Patterns And Inflammatory Markers During Pregnancy: A Systematic Review, Kuan-Lin Yeh, Amber Kautz, Barbara A. Lohse, Susan W. Groth Mar 2021

Associations Between Dietary Patterns And Inflammatory Markers During Pregnancy: A Systematic Review, Kuan-Lin Yeh, Amber Kautz, Barbara A. Lohse, Susan W. Groth

Articles

Elevated inflammation in pregnancy has been associated with multiple adverse pregnancy outcomes and potentially an increased susceptibility to future chronic disease. How maternal dietary patterns influence systemic inflammation during pregnancy requires further investigation. The purpose of this review was to comprehensively evaluate studies that assessed dietary patterns and inflammatory markers during pregnancy. This review was guided by the Preferred Reporting Items for Systematic Review and Meta-Analyses. Included studies were sourced from EMBASE, PubMed, Web of Science, and Scopus and evaluated using The Quality Assessment Tool for Quantitative Studies. Inclusion criteria consisted of human studies published in English between January 2007 …


No Evidence That Salt Water Ingestion Kills Adult Mosquitoes (Diptera: Culicidae), Donald A. Yee, Catherine Dean, Cameron Webb, Jennifer A. Henke, Gabriela Perezchica-Harvey, Gregory S. White, Ary Faraji, Joshua D. Macaluso, Rebecca Christofferson Mar 2021

No Evidence That Salt Water Ingestion Kills Adult Mosquitoes (Diptera: Culicidae), Donald A. Yee, Catherine Dean, Cameron Webb, Jennifer A. Henke, Gabriela Perezchica-Harvey, Gregory S. White, Ary Faraji, Joshua D. Macaluso, Rebecca Christofferson

Faculty Publications

Various products and insecticides are available that purport to reduce wild populations of adult mosquitoes. Recently, several manufacturers and general public comments on the internet have promoted devices that claim that ingestion of salt will significantly reduce populations of wild mosquitoes to near zero; there are no known scientific efficacy data that support these claims. We tested the survival of nine mosquito species of pest and public health importance across four adult diets: Water Only, Sugar Water Only (8.00%), Salt Water Only (1.03%), and Sugar + Salt Water. Species included the following: Aedes aegypti (L.), Aedes albopictus (Skuse), Aedes dorsalis …


Deficiency Of Stat1 In Cd11c+ Cells Alters Adipose Tissue Inflammation And Improves Metabolic Dysfunctions In Mice Fed A High-Fat Diet, Antu Antony, Zeqin Lian, Xiaoyuan Dai Perrard, Jerry Perrard, Hua Liu, Aaron R Cox, Pradip Saha, Lothar Hennighausen, Sean M Hartig, Christie M Ballantyne, Huaizhu Wu Mar 2021

Deficiency Of Stat1 In Cd11c+ Cells Alters Adipose Tissue Inflammation And Improves Metabolic Dysfunctions In Mice Fed A High-Fat Diet, Antu Antony, Zeqin Lian, Xiaoyuan Dai Perrard, Jerry Perrard, Hua Liu, Aaron R Cox, Pradip Saha, Lothar Hennighausen, Sean M Hartig, Christie M Ballantyne, Huaizhu Wu

Faculty, Staff and Students Publications

CD11c+ macrophages/dendritic cells (MDCs) are increased and display the classically activated M1-like phenotype in obese adipose tissue (AT) and may contribute to AT inflammation and insulin resistance. Stat1 is a key transcription factor for MDC polarization into the M1-like phenotype. Here, we examined the role of Stat1 in obesity-induced AT MDC polarization and inflammation and insulin resistance using mice with specific knockout of Stat1 in MDCs (cKO). Stat1 was upregulated and phosphorylated, indicating activation, early and persistently in AT and AT MDCs of wild-type mice fed a high-fat diet (HFD). Compared with littermate controls, cKO mice fed an HFD (16 …


Rural Residents' Perspectives On An Mhealth Or Personalized Health Coaching Intervention: Qualitative Study With Focus Groups And Key Informant Interviews, Nancy Schoenberg, Madeline Dunfee, Hannah Yeager, Matthew Rutledge, Angela Pfammatter, Bonnie Spring Feb 2021

Rural Residents' Perspectives On An Mhealth Or Personalized Health Coaching Intervention: Qualitative Study With Focus Groups And Key Informant Interviews, Nancy Schoenberg, Madeline Dunfee, Hannah Yeager, Matthew Rutledge, Angela Pfammatter, Bonnie Spring

Behavioral Science Faculty Publications

BACKGROUND: Compared with national averages, rural Appalachians experience extremely elevated rates of premature morbidity and mortality. New opportunities, including approaches incorporating personal technology, may help improve lifestyles and overcome health inequities.

OBJECTIVE: This study aims to gather perspectives on whether a healthy lifestyle intervention, specifically an app originally designed for urban users, may be feasible and acceptable to rural residents. In addition to a smartphone app, this program-Make Better Choices 2-consists of personalized health coaching, accelerometer use, and financial incentives.

METHODS: We convened 4 focus groups and 16 key informant interviews with diverse community stakeholders to assess perspectives on this …


Maternal Dietary Quality, Inflammatory Potential And Childhood Adiposity: An Individual Participant Data Pooled Analysis Of Seven European Cohorts In The Alphabet Consortium, Ling-Wei Chen, Adrien M. Aubert, Nitin Shivappa, Jonathan Y. Bernard, Sara M. Mensink-Bout, Aisling A. Geraghty, John Mehegan, Matthew Suderman, Kinga Polanska, Wojciech Hanke, Agnieszka Jankowska, Caroline L. Relton, Sarah R. Crozier, Nicholas C. Harvey, Cyrus Cooper, Mark Hanson, Keith M. Godfrey, Romy Gaillard, Liesbeth Duijts, Barbara Heude, James Hébert Scd, Fionnuala M. Mcauliffe, Cecily Kelleher, Catherine M. Phillips Feb 2021

Maternal Dietary Quality, Inflammatory Potential And Childhood Adiposity: An Individual Participant Data Pooled Analysis Of Seven European Cohorts In The Alphabet Consortium, Ling-Wei Chen, Adrien M. Aubert, Nitin Shivappa, Jonathan Y. Bernard, Sara M. Mensink-Bout, Aisling A. Geraghty, John Mehegan, Matthew Suderman, Kinga Polanska, Wojciech Hanke, Agnieszka Jankowska, Caroline L. Relton, Sarah R. Crozier, Nicholas C. Harvey, Cyrus Cooper, Mark Hanson, Keith M. Godfrey, Romy Gaillard, Liesbeth Duijts, Barbara Heude, James Hébert Scd, Fionnuala M. Mcauliffe, Cecily Kelleher, Catherine M. Phillips

Faculty Publications

Background

Mounting evidence suggests that maternal diet influences pregnancy and birth outcomes, but its contribution to the global epidemic of childhood obesity has not as yet been definitively characterized. We investigated whether maternal whole diet quality and inflammatory potential influence childhood adiposity.

Methods

We harmonized and pooled individual participant data from 16,295 mother-child pairs in seven European birth cohorts. Maternal pre-, early-, late-, and whole-pregnancy (any time during pregnancy) dietary quality and inflammatory potential assessed with the Dietary Approaches to Stop Hypertension (DASH) score and the energy-adjusted Dietary Inflammatory Index (E-DII™) score, respectively. Primary outcome was childhood overweight and obesity …


Influence Of Diet On Metabolic Physiology In People With And Without A Family History Of Type 2 Diabetes, Smaran Marupudi, Yu Lun Tai, Gabriel Figueroa, Saraswathy Nair, Jimmy Gonzalez, Emily Cisneros, Ryan D. Russell Feb 2021

Influence Of Diet On Metabolic Physiology In People With And Without A Family History Of Type 2 Diabetes, Smaran Marupudi, Yu Lun Tai, Gabriel Figueroa, Saraswathy Nair, Jimmy Gonzalez, Emily Cisneros, Ryan D. Russell

International Journal of Exercise Science: Conference Proceedings

Type 2 diabetes (T2D) prevalence in the Rio Grande Valley is ~27% versus the 9% national average. Simply having a family history (FH+) of type 2 diabetes (T2D) increases T2D prevalence by ~40 over those with no family history (FH-). We have shown that FH+ display early markers of cardiometabolic impairment vs FH-, such as blunted microvascular reactivity, and impaired metabolic flexibility. What is not yet known is the degree to which environment vs genetics may contribute to these impairments. PURPOSE: This pilot study seeks to examine normal dietary patterns between FH groups to identify potential patterns in macro- and …


Vertical Sleeve Gastrectomy Confers Metabolic Improvements By Reducing Intestinal Bile Acids And Lipid Absorption In Mice, Lili Ding, Eryun Zhang, Qiaoling Yang, Lihua Jin, Kyle M Sousa, Bingning Dong, Yangmeng Wang, Jui Tu, Xiaoxiao Ma, Jingyan Tian, Hongli Zhang, Zhipeng Fang, Ana Guan, Yixin Zhang, Zhengtao Wang, David D Moore, Li Yang, Wendong Huang Feb 2021

Vertical Sleeve Gastrectomy Confers Metabolic Improvements By Reducing Intestinal Bile Acids And Lipid Absorption In Mice, Lili Ding, Eryun Zhang, Qiaoling Yang, Lihua Jin, Kyle M Sousa, Bingning Dong, Yangmeng Wang, Jui Tu, Xiaoxiao Ma, Jingyan Tian, Hongli Zhang, Zhipeng Fang, Ana Guan, Yixin Zhang, Zhengtao Wang, David D Moore, Li Yang, Wendong Huang

Faculty, Staff and Students Publications

Vertical sleeve gastrectomy (VSG) is a highly effective bariatric surgery that sustainably treats obesity and type 2 diabetes (T2D). However, the underlying mechanisms governing its metabolic benefits remain unclear. In this study, we have used four different genetically modified mouse lines to understand the link between bile acid circulation and metabolic effects of VSG. Instead of directly activating the nuclear bile acid receptor farnesoid X receptor (Fxr) in the liver or intestine, VSG reduces intestinal levels of bile acids, thereby decreasing fat absorption in the intestine. Given the rising popularity of bariatric surgeries to treat obesity and associated T2D, the …


Cancer Survivorship In Hematologic Malignancies: Lifestyle Changes After Diagnosis, Pannaga Malalur, Manas Agastya, Sandhya Wahi-Gururaj, Chad L. Cross, Delva Deauna-Limayo, Edwin C. Kingsley Feb 2021

Cancer Survivorship In Hematologic Malignancies: Lifestyle Changes After Diagnosis, Pannaga Malalur, Manas Agastya, Sandhya Wahi-Gururaj, Chad L. Cross, Delva Deauna-Limayo, Edwin C. Kingsley

School of Medicine Faculty Research

© 2020 The Authors. Cancer Medicine published by John Wiley & Sons Ltd. Background: Studies show that patients make lifestyle changes soon after certain solid tumor diagnoses, suggesting that this may be a teachable moment to motivate and promote healthy behaviors. There is a paucity of data regarding changes made after a diagnosis of a hematologic malignancy. Methods: A cross-sectional study of 116 patients at a community oncology center who completed anonymous questionnaires was performed. Questions addressed lifestyle choices made with respect to smoking, alcohol consumption, recreational drug use, diet, and exercise habits before and after diagnosis of a hematologic …


Fructan-Sensitive Children With Irritable Bowel Syndrome Have Distinct Gut Microbiome Signatures, Bruno P Chumpitazi, Kristi L Hoffman, Daniel P Smith, Ann R Mcmeans, Salma Musaad, James Versalovic, Joseph F Petrosino, Robert J Shulman Feb 2021

Fructan-Sensitive Children With Irritable Bowel Syndrome Have Distinct Gut Microbiome Signatures, Bruno P Chumpitazi, Kristi L Hoffman, Daniel P Smith, Ann R Mcmeans, Salma Musaad, James Versalovic, Joseph F Petrosino, Robert J Shulman

Children’s Nutrition Research Center Staff Publications

Background: Dietary fructans may worsen gastrointestinal symptoms in children with irritable bowel syndrome (IBS).

Aim: To determine whether gut microbiome composition and function are associated with childhood IBS fructan-induced symptoms.

Methods: Faecal samples were collected from 38 children aged 7-17 years with paediatric Rome III IBS, who previously completied a double-blind, randomised, placebo-controlled crossover (fructan vs maltodextrin) trial. Fructan sensitivity was defined as an increase of ≥30% in abdominal pain frequency during the fructan diet. Gut microbial composition was determined via 16Sv4 rDNA sequencing. LEfSe evaluated taxonomic composition differences. Tax4Fun2 predicted microbial fructan metabolic pathways.

Results: At baseline, 17 fructan-sensitive …


Acetic Acid Supplementation: Effect On Resting And Exercise Energy Expenditure And Substrate Utilization, Kolton M. Cobb, Domenico A. Chavez, Jonathan D. Kenyon, Zachary J. Hutelin, Michael Webster Jan 2021

Acetic Acid Supplementation: Effect On Resting And Exercise Energy Expenditure And Substrate Utilization, Kolton M. Cobb, Domenico A. Chavez, Jonathan D. Kenyon, Zachary J. Hutelin, Michael Webster

International Journal of Exercise Science

International Journal of Exercise Science 14(2): 222-229, 2021. The purpose of this study was to investigate the influence of acetic acid (apple cider vinegar; ACV) supplementation on resting and exercise energy expenditure and substrate utilization. Using a randomized, double blind, crossover design, 16 healthy subjects were supplemented for 4 d with either ACV (30-ml/d) mixed in 1 L of a non-nutritive lemon-flavored drink or a placebo (PLA). They were then assessed via indirect calorimetry for resting energy expenditure (REE) and substrate utilization. This was immediately followed by the assessment of steady state cycling exercise energy expenditure at 40 W (EEE-40) …


Diet Of An Important Wetland Resident, The California Killifish, Fundulus Parvipinnis, In A Natural And Created Marsh Habitat In Mission Bay, California, Katie Robinson-Filipp Jan 2021

Diet Of An Important Wetland Resident, The California Killifish, Fundulus Parvipinnis, In A Natural And Created Marsh Habitat In Mission Bay, California, Katie Robinson-Filipp

Theses

The California killifish, Fundulus parvipinnis Girard, is an ecologically important marsh resident. Fundulus parvipinnis is a low-level carnivore, displaying high-site fidelity and occurring in high densities across a range of environmental conditions. Despite the importance of F. parvipinnis to the ecosystem functions of the threatened coastal wetlands of southern California and the Baja California Peninsula, there are critical gaps in our knowledge of this species. In particular, information on their diet and food habits is lacking.

Understanding wetland food web linkages, interactions, and trophic transfer is essential for informing effective habitat management and contributes to our ability to evaluate the …


If We Build It, Will They Come?, Lewis Bollard Jan 2021

If We Build It, Will They Come?, Lewis Bollard

Diet

You know things are going well when Bill Gates is talking up the potential of plant-based meat with Anderson Cooper on 60 Minutes. Gates even told Forbes that beyond Meat and Impossible Foods’ success has given him hope for solving meat’s climate impact.Other investors are equally excited. In just the first seven months of 2020, they invested about $1.5B in alternative protein startups (see chart below). The Good Food Institute now tracks 510 companies working on plant-based, cultivated, or fermented alternatives to animal proteins. Many of these companies are racing to make alternatives as cheap and tasty as animal …


Physical Activity, Dietary Patterns, And Glycemic Management Of Active Individuals With Type 1 Diabetes: An Online Survey, Sheri Colberg, Jihan Kannane, Norou Diawara Jan 2021

Physical Activity, Dietary Patterns, And Glycemic Management Of Active Individuals With Type 1 Diabetes: An Online Survey, Sheri Colberg, Jihan Kannane, Norou Diawara

Human Movement Studies & Special Education Faculty Publications

Individuals with type 1 diabetes (T1D) are able to balance their blood glucose levels while engaging in a wide variety of physical activities and sports. However, insulin use forces them to contend with many daily training and performance challenges involved with fine-tuning medication dosing, physical activity levels, and dietary patterns to optimize their participation and performance. The aim of this study was to ascertain which variables related to the diabetes management of physically active individuals with T1D have the greatest impact on overall blood glucose levels (reported as A1C) in a real-world setting. A total of 220 individuals with T1D …


Nutritional Status, Physical Activity, Sedentary Behavior, Diet, And Lifestyle In Childhood: An Analysis Of Respiratory Diseases In Adolescence, Eduardo Rossato De Victo, Gerson Ferrari, Victor Keihan Rodrigues Matsudo, Carlos André Miranda Pires, Timóteo Leandro Araújo, Peter Todd Katzmarzyk, Dirceu Solé Jan 2021

Nutritional Status, Physical Activity, Sedentary Behavior, Diet, And Lifestyle In Childhood: An Analysis Of Respiratory Diseases In Adolescence, Eduardo Rossato De Victo, Gerson Ferrari, Victor Keihan Rodrigues Matsudo, Carlos André Miranda Pires, Timóteo Leandro Araújo, Peter Todd Katzmarzyk, Dirceu Solé

Population and Public Health Science Faculty Publications

Objective: To evaluate the association between nutritional status, physical activity, sedentary behavior, diet, and lifestyle in childhood with respiratory diseases during adolescence. Methods: Prospective study conducted in Saõ Caetano do Sul, Saõ Paulo-Brazil, as part of the International Study of Childhood Obesity, Lifestyle and the Environment (ISCOLE). During childhood, indicators of lifestyle (body composition, physical activity, sedentary behavior, diet) and family environment were measured in 2012 and 2013. After five years, participants answered the International Study of Asthma and Allergies in Childhood (ISAAC) questionnaire for the diagnosis of respiratory diseases (asthma and/or rhinitis). Analyses were determined by logistic regression. Results: …