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Genetic Variation In Slc6a4 And Cytochrome P450 Enzymes: Implications For Personalized Antidepressant Treatment In Major Depressive Disorder, Claudia Buda

Harriet L Wilkes Honors College Theses 2020 - Present

Depression is one of the most common psychiatric disorders worldwide, with a significant impact on quality of life and global health. Despite the widespread use of selective serotonin reuptake inhibitors (SSRIs) as first-line treatment, individual responses vary significantly due to genetic differences. Variations in the serotonin transporter gene (SLC6A4) and the cytochrome P450 (CYP450) enzyme family have been identified as key factors influencing the efficacy, metabolism, and tolerability of SSRIs. This thesis examines the impact of polymorphisms in SLC6A4 and CYP450 on SSRI pharmacodynamics and pharmacokinetics, explores their potential for guiding personalized antidepressant therapy, and discusses the ethical and practical …

Age Of First Smartphone Ownership With Social Media Access And Its Impact On Mental Health Outcomes, Derrick W. Swandol

Doctoral Dissertations and Projects

The purpose of this quantitative study was to examine the relationship between the age of smartphone ownership with social media access (ASO) and self-esteem and depression symptoms, as well as to determine if the results could be moderated by adverse childhood experiences (ACEs) as an individual transitions from adolescence to adulthood. The study was conducted with n=54 (72% female), of whom 83% first owned a smartphone with social media access ≥ 12 years-of-age. This study was unable to obtain the minimum sample size for a statistically significant study and is considered underpowered due to needing a minimum sample size of …

Lived Experiences Of Individuals With Adverse Childhood Experiences And Mitigating Factors Of Personal Spiritual Disciplines, Carolyn Potts Simoneaux

Doctoral Dissertations and Projects

This qualitative phenomenological study sought to understand the impacts of adverse childhood experiences (ACEs) and what mitigating factors can help alleviate the pain and suffering caused by their residual life-long impacts. A literature review was done, and a gap was found on the subjects of personal spiritual disciplines (PSDs) of prayer, Bible reading/study, public/private worship, repentance and forgiveness as mitigating factors for the impacts of ACEs. This study recruited 15 participants who identified as victims of ACEs and used PSDs as mitigating factors to overcome the lifelong impacts. Interviews were done, using an online forum, to question participants on their …

Mental Health In Relation To Parental Absence: A Systematic Review, Mohammed Barry, Abdulaziz Alyahyawi, Heba Jafar Sabbagh

Saudi Medical Journal

Objective: To evaluate the literature based on the relationship between orphaned children and mental health, compared to non-orphaned children. Mental well-being of orphaned children is a profound intricate topic that connects with broader concerns of childcare. This systematic review aims to evaluate the literature regarding the relationship between mental health and parental absence. Methods: We conducted a systematic search of PubMed, MEDLINE, and Science Direct in October 2025, with 1017 screened studies. Six studies met the inclusion criteria. Independent reviewers performed quality assessments using the Newcastle-Ottawa scale (NOS). Subsequently, a meta-analysis was performed when possible. Results: Findings indicate that orphaned …

Does Mandated Paid Maternity Leave Affect Postpartum Depression?, Amaya S. Hall, Shay Y. Bullwinkel, Loran M. Hurley, Sara Cook

Epsilon Sigma at-Large Research Conference

This project analyzes the effects that paid maternity leave has on postpartum depression. Upon reviewing multiple studies, it has been demonstrated that unpaid maternity leave is associated with postpartum depression. Throughout researching postpartum depression rates, it has been proven to be much higher in unpaid leave compared to paid maternity leave. Mothers that have the burden of staying home with their infants and having to juggle time off work, without being compensated, are at an increased risk of experiencing postpartum depression. It has been shown that when a mother is able to focus on her child and her healing after …

Therapeutic Applications Of Tabletop Role-Playing Games In Treatment Of Depressive And Anxious Symptoms In Young Adults, Dash Degrote

Honors Theses

Tabletop role-playing games (TTRPGs) are played by a large population and involve the engagement of social and emotional skills, with the largest portion of the population playing them being adolescents or young adults. The therapeutic application of TTRPGs in the treatment of depressive and anxious symptoms shows potential with this population. In a literature review, three major themes are identified: TTRPG culture, stakeholder perspectives of TTRPGs, and examples of therapeutically-applied TTRPGs. Overall, evidence suggests that TTRPGs can positively impact the concerned symptoms, though more research is needed for games outside of Dungeons & Dragons as well as stakeholder perspectives.

Helping Others To Help Yourself: Effects Of Prosocial Behavior On Anxiety And Depression, Matheus Muniz Pereira Vargas

Psychology Student Publications

Helping others is a good way to help prevent psychological disorders. The literature reviewed here points towards a protective and mitigating effect on symptoms of anxiety and depression brought upon by prosocial behaviors. Prosocial behavior is associated with higher positive moods in participants with depression (Schacter & Margolin, 2019), it is negatively correlated with feelings of reported rates of depression, anxiety and isolation (Naclerio et al., 2026), and seems to have a protective effect against development and exacerbation of anxiety (Okuyucu et al., 2024). All of that indicates that encouraging these behaviors lead to more positive mental health outcomes without …

Critical Analysis Of Psychiatric Medications, And Their Effects On Patients With Post-Orthostatic Tachycardia Syndrome(Pots), Joshua Lovelock, Michael Gibson, Fernando Izaguirre, Daniel Hong

Research Day

Background: Postural Orthostatic Tachycardia Syndrome (POTS) is a form of autonomic dysfunction defined by an excessive increase in heart rate (>30bpm within 10 minutes) upon standing and symptoms such as lightheadedness, palpitations, and, in some cases, syncope. Because many POTS symptoms overlap with those of anxiety and depression, psychiatric medications are commonly considered, but there’s a risk they may affect the heart rate and blood pressure.

Objective: To summarize how common psychiatric medication classes may impact autonomic function in patients with POTS.

Methods: This project reviewed the autonomic effects of antidepressant classes (SSRIs, SNRIs, TCAs) from peer reviewed articles. …

The Impact Of Traumatic Event Exposure On Ptsd, Depression, And Anxiety Among Veterans, Casie Daum, Emily Rabinowitz, Ken Marfilius, Joseph W. Ditre

Voices of Service Symposium

Background: Psychiatric disorders including post-traumatic stress disorder (PTSD), depression, and anxiety are highly common and debilitating conditions among veterans. Exposure to potentially traumatic events (PTEs) such as active combat, blast exposure, close calls, and witnessing injury or death during military service may be a significant risk factor for the development and maintenance of psychiatric conditions. This analysis sought to examine the extent to which individuals with PTE exposure related to military service had different levels of psychiatric symptoms. Method: A sample of 266 veterans were recruited using Prolific, an online research panel service. Participants completed the Primary Care PTSD Screen …

The Impact Of A Mindfulness Meditation Program On Phq-9 Scores In Eskd Clients At The Dialysis Center, Christi Collins Weaver

Student Scholarly Projects

Practice Problem: Patients undergoing hemodialysis for end-stage kidney disease (ESKD) experience high rates of untreated depressive symptoms, which negatively impact quality of life, treatment adherence, and therefore increased hospitalization and higher mortality rates.

PICOT: In adult patients receiving in-center hemodialysis (P), how does the implementation of a structured mindfulness meditation program (I), compared to usual care (C), affect depressive symptoms as measured by the Patient Health Questionnaire-9 (PHQ-9) (O) over an eight-week period (T)?

Evidence: Current literature demonstrates that depression is highly prevalent among individuals with ESKD and is associated with increased morbidity and decreased treatment adherence. Evidence supports mindfulness …

Amyotrophic Lateral Sclerosis Risk Perceptions And Patient Burden, John William Glisson

Doctoral Dissertations and Projects

This quantitative, non-experimental, cross-sectional correlational study examined relationships among perceived environmental risk factors, depressive symptoms, and functional symptom burden in adults diagnosed with Amyotrophic Lateral Sclerosis (ALS). ALS is a progressive neurodegenerative condition with an unclear etiology, and some individuals attribute the diagnosis to environmental exposures such as pesticides or military service. The purpose of this study was to assess whether environmental risk perceptions were associated with depressive symptoms or functional impairment, and whether depressive symptoms were associated with functional status. Participants were recruited through online ALS support networks and advocacy organizations, resulting in a final sample of 145 adults …

Schema Therapy For The Treatment Of Chronic Depression: A Critical Review Of Evidence-Based Treatment Methods, Trevor Ink

Doctoral Dissertations and Projects

This review explores current evidence-based interventions for the treatment of depression. Many of the current interventions display moderate to high levels of efficacy in decreasing depression severity and are praised for their effectiveness. However, many current front-line interventions fail to address the root cause of depressive symptomology. Schema therapy is an integrative treatment that targets core emotional needs that failed to be met during crucial developmental stages. Originally developed for personality disorders, schema therapy is effective for a myriad of disorders, including chronic depression. By targeting early maladaptive schemas (EMS), schema therapy can be effective for treating chronic depression when …

Balneotherapy For Sleep Improvement And Reducing Depression In Knee Osteoarthritis Patients, Anca Paula Ciurba, Alexandru Bogdan Ilieș, Ionel Haidu, Doriana Ioana Ciobanu, Theodora Ursu, Florin Mihai Marcu, Dorina Ianc

Baltic Journal of Health and Physical Activity

Background: Knee osteoarthritis (OA) is the most common chronic condition and a leading cause of global disability, often associated with pain, depression, and sleep disturbances. The purpose of this study was to investigate the effectiveness of warm mineral water combined with physical therapy on sleep quality, depression and pain intensity in patients with knee osteoarthritis. Materials and Methods: The study involved 101 subjects (68.78±6.92 years) who were assigned to  a control group (CG) or an experimental group (EG). All subjects benefited from physical therapy and electrotherapy for 10 days. The experimental group additionally benefited from therapy with hot mineral water. …

Effect Of Ginseng On Obesity And Neurogenesis, Hayden L. Withers, Claudia A. Grillo, Lawrence P. Reagan, Natalia Maciejewska, Sai V. Nallu, Jennifer L. Woodruff

Senior Theses

Obesity and major depressive disorder are two conditions with high comorbidity as well as overlapping pathophysiological mechanisms, including neuroinflammation, metabolic/endocrine dysfunction, and impaired hippocampal neurogenesis. Panax ginseng, a medicinal herb, is known to demonstrate anti-inflammatory and metabolic regulatory properties. Ginseng has demonstrated its effective antidepressant-like effects within preclinical studies, but its potential to restore neurogenesis in the context of obesity-induced depression is not clear. Within this study, male Sprague-Dawley rats were tested in either a high fat diet (HFD) or control diet (Cont) for 12 weeks and then was treated subsequently with daily intraperitoneal injections of either ginseng or saline …

Behavioral Strategies And Mental Health Reactions To Social Preference Insecurity: The Effect On Social Preference And The Moderating Role Of Machiavellianism, Alexandra Zingarelli

Theses and Dissertations from DePaul University

Adolescents experience insecurity about social preference; however, its role in adolescent behavioral and mental health and subsequent social preference has not been studied. Additionally, individual differences in personality further contribute to adolescent’s behavioral and mental health development and subsequent peer liking. Using a longitudinal and muti-informant design, the present study examined whether social preference insecurity (SPI) predicted social preference through the mediation of aggression and depression and examined whether Machiavellian traits moderated these pathways among 817 adolescents (Age: M=12.19 SD=0.813, Male: n=409, 50%; Female: n=409, 50%) from middle schools in the U.S. Midwestern states. The results showed that Time 1 …

The Impact Of Social Determinants Of Health On The Emotional Well-Being Of Lgbtq Young Adults, Bridget J. Mantooth-Urso

Electronic Theses and Dissertations 2020 - Present

The current study examined whether neighborhood-based social determinants of health (SDOH) were associated with emotional health outcomes among sexual minority young adults ages 18–29, and whether perceived social support mediated this relationship. SDOH refers to the conditions in which individuals are born, grow, live, work, and age, including neighborhood and built environment characteristics that shape access to resources, safety, and well-being. Emotional health in this study was operationalized through self-reported symptoms of depression and anxiety, while social support represented perceived availability and quality of interpersonal resources that may buffer the impact of structural disadvantage. This study utilized a non-experimental, cross-sectional …

Iron Deficiency And Depressive Symptoms: Effects Of Racial And Ethnic Disparity In Two Reproductive-Aged Us Women, Alexis Monkhouse

USF Tampa Graduate Theses and Dissertations

Problem: Reproductive- aged women are one of the populations most at risk for iron deficiency and depression in the United States. While many studies have looked at the relationship between these two illnesses, none have explored it from a biocultural framework, examining how race/ethnicity affects this relationship. Using data from NHANES, this thesis examined the relationship between iron status (total body iron) and depressive symptoms (PHQ-9) among reproductive-aged women in the U.S. and how race/ethnicity affects it. Methods. NHANES survey data from 2005-2010 were pulled. Demographic and laboratory data were used to determine eligibility, total body iron, and depressive scores. …

Behavioral Practice And Homework Completion As Predictors Of Outcome In A Transdiagnostic Brief Behavioral Therapy For Anxiety And Depression In Youth., Araceli Gonzalez, Pauline Goger, Melissa Escobar, Michelle Rozenman, Megan Jeffreys, Giovanna Porta, David A. Brent, Frances L. Lynch, John F. Dickerson, V. Robin Weersing

Department of Psychology Faculty Scholarship and Creative Works

Exposure and behavioral activation have been identified as key therapeutic components in evidence-based treatment for youths with anxiety and depression, respectively. The current study expanded this work to transdiagnostic treatment for youths with anxiety and depression and examined links between (a) amount of in-session exposure/behavioral activation, (b) out-of-session homework completion, and (c) anxiety, depression, and functioning outcomes of youths following a brief behavioral therapy. Therapy data were examined from 95 youths (ages 8-16; 56.8% female; 74.7% non-Hispanic White) with anxiety and/or depressive disorders who completed a transdiagnostic Brief Behavioral Therapy (BBT) as part of a randomized effectiveness trial. Observers recorded …

Moving Towards Wellness: How Exercise Can Ease Depression And Anxiety In Young Adults, Morgan Hartze

Psychology Student Publications

Depression and anxiety are among the most common mental health concerns affecting young adults, impacting mood, motivation, and daily functioning. While therapy and medication can be effective, many young adults continue to experience symptoms, highlighting the need for additional strategies. Research suggests that regular physical activity is an accessible, cost-effective way to improve mental health. Moving your body boosts the “feel good” chemicals, such as serotonin and dopamine, while reducing stress hormones, such as cortisol. Physical activity also provides a healthy distraction from negative thoughts and helps establish routines that support well-being. Even brief amounts of moderate exercise, such as …

The Relationship Between Childhood Adverse Experiences And Adult Depression, Alexander Owens

Psychology Student Publications

This paper explores the current understanding of the linkage between childhood trauma and depression. Before this, childhood trauma and adult depression are described. Overall, there are a few different ways these two constructs can be linked, and they are explored.

Clinically Aligned Long-Context Transformers For Cross-Platform Mental Health Risk Detection, Aditya Tekale, Mohammad Masum

Faculty Research, Scholarly, and Creative Activity

Social media platforms contain rich but noisy narratives of psychological distress, creating opportunities for early mental health risk detection. However, existing datasets capture heterogeneous constructs such as suicide risk severity, depression diagnosis, and DSM-5 symptom presence, and most prior models are trained and evaluated on a single corpus, limiting their clinical alignment and cross-dataset generalizability. In this study, we fine-tune a domain-specific long-document transformer, AIMH/Mental-Longformer-base-4096, for binary mental health risk detection (risk vs. no risk) using two clinically aligned Reddit datasets: the C-SSRS Reddit corpus and the eRisk 2025 depression dataset. To handle long user histories, we introduce an LLM-based …

Collaborative Care For Depression In Chronic Illness: A Narrative Review, Chun Wong, German E. Corso

School of Medicine Publications

Background: Depression commonly coexists with chronic medical illness and is associated with impaired self-management, poor adherence, increased healthcare utilization, and higher mortality.

Objective: To synthesize evidence published between 2000 and late 2025 on the effectiveness of the Collaborative Care Model (CoCM) for depression in adults with chronic medical illness, with particular attention to contemporary U.S. implementation, policy, and equity considerations.

Methods: A narrative review of randomized controlled trials, pragmatic and implementation studies, systematic reviews, and policy analyses was conducted using PubMed, PsycINFO, and Scopus. Evidence addressing collaborative care for depression in adults with chronic medical illness was identified and synthesized …

"Bibliotherapy In Counseling, Spirituality, And Self-Care-How Reading The Right Book Can Heal", Michelle P. Cross

English

Bibliotherapy can be used as an integral component of mental and emotional self-care, spiritual growth, and professional therapy. Reading can be instrumental for sharpening mental acuity, alleviating depression, and furthering spiritual journeys. Bibliotherapy can provide a modicum of treatment to those who cannot access traditional clinics or religious/spiritual centers.

Behind The Jersey: Exploring Athletic Identity And Depression In College Athletes, Matt A. Moore, Lana Loken, Anne Kelly, Mastano Nambiro Woleson Dzimbiri, Payton Bennett, Lawrence W. Judge

Journal of Athlete Development and Experience

A significant increase in mental health concerns among college athletes has fueled interest in the impact of athletic identity on psychological outcomes. Research has produced mixed results regarding the association between athletic identity and mental health. This study sought to clarify this relationship and to improve our understanding of depression among NAIA college athletes, especially those who attach a great degree of importance and strength to the athlete’s role in relation to other activities. Voluntary college athletes aged 18-years-old or older and attending an NAIA member institution participated in the study (n = 361). They completed a web-based instrument that …

Depression And Psychotic Disorders Worsen Perioperative Outcomes And Increase Resource Utilization After Multilevel Lumbar Fusion: Implications For Screening And Perioperative Care, Leonidas E. Mastrokostas, Paul G. Mastrokostas, Luke B. Schwartz, Abigail Razi, Sean Inzerillo, John K. Houten, Arya Varthi, Alex R. Vaccaro, Jad Bou Monsef, Afshin E. Razi, Mitchell K. Ng

Rothman Institute Papers

CONTEXT: Multilevel lumbar fusion use has increased with an aging U.S. population. Depression and psychotic disorders are linked to poorer surgical outcomes, but their effects in this setting are unclear.

AIMS: The aims of this study were to quantify the prevalence of these disorders and evaluate associations with perioperative outcomes and resource use.

SETTINGS AND DESIGN: This was a retrospective cohort study using the National Inpatient Sample from 2016 to 2022.

SUBJECTS AND METHODS: Depression and psychotic disorders were defined using Elixhauser-derived indicators. Outcomes included medical and mechanical complications, discharge disposition, length of stay (LOS), and costs.

STATISTICAL ANALYSIS USED: …

Depression, Belonging, And Self-Censorship About Palestine Among Arab Americans, Ghadir Habeeb, Amanda Jiang, Batool Alderawi, Yara Mekawi, Nadia Al-Dajani

The Cardinal Edge

Background: As a result of exposure to traumatic media depicting the Gaza genocide, many Arab Americans are moved to speak up in support of Palestine. Due to the suppression of pro-Palestinian advocacy, however, many Arab Americans self-censor as a defense mechanism, which can alleviate distress but can also exacerbate depressive symptoms. Belongingness may serve as a protective factor against the negative effects of self-censorship. Centering Arab Americans’ experiences, this study examines the relationship between self-censorship and depression, as well as the role of belongingness in this association.

Method: Arab Americans adults recruited through Qualtrics Survey Panels completed questionnaires assessing self-censorship, …

Obesity And Suicide Behavior In Young Latina Adults Of Mexican Heritage: The Mediating Influences Of Sleep Problems, Health Problems, And Dissatisfaction With Personal Appearance, Joseph D. Hovey, Liza Talavera-Garza, Glenn Gray, Isabella A. Cruz, Nadeen Salhadar, Monica E. Ochoa

Psychological Science Faculty Publications

Although research findings have indicated that obesity is associated with suicide behavior, especially in females, scant research has examined mediators in this relationship. Moreover, although suicides have increased in young Latina adults in the United States, no published studies have examined obesity and suicide risk in young Latina adults. The present study thus examined the relationship of obesity to suicide behavior in young Latina adults and assessed sleep problems, health problems, and dissatisfaction with personal appearance as possible mediators. Participants were 401 female students of Mexican heritage from South Texas who completed the National College Health Assessment II, from which …

Depression In Burn Patients At Al-Diwaniya Teaching Hospital, Ali Al Hamzawi, Inas Hussein Abed, Ahmed Miri Saadoon

Al-Qadisiyah Medical Journal

Background Burn injuries affact on physical and mental status of the victum.  The researchers show different outcome in their articles when they study depression in burned patients. Aim of the study  The study aims are : 1. identify the prevalence rate of depression in burn patients. 2.measure  severity of depression .3. study the  socio-demographic variables of those patients. Methods A case –control study was condefed  on One hunderd patients at the burn unit of AL- Diwaniya Teaching Hospital from a period of April 2nd  2014 to January 2nd 2015. the presence of depression was diagnosed by using a semi –structured …

Depression Intype2 Diabetic Patients In Al-Diwaniyah Teaching Hospital, Aqeel Raheem Hassan, Abdul Zahra Mohammad Al Khafaji, Adil Hammadi

Al-Qadisiyah Medical Journal

Objectives: Depression is commonly found as a comorbid condition in chronic medical illnesses in general, and diabetes mellitus (DM) in particular. Patients with diabetes are twice as likely to suffer from depression as compared to the general population. The aims of the study were to estimate: the prevalence of depression in type 2diabetic patients and its severity, the rate of depression in type 2 diabetes in relation to socio-demographic variables, and to find out the correlation of depression with some diabetes variablesMethods:100 Iraqi patients with type 2 DM compared with 100 persons from general population as control group participated in …

Depression Among Internally Displaced People After February 22,2006 In Al-Diwaniya Governorate, Abdulzahra Mohammed Alkhafaji, Hassan Rajii Jallab, Salah Mahdi Yassien

Al-Qadisiyah Medical Journal

Background Internally displaced persons (IDPs) are those who have been forced from their home but, unlike refugees, remain within the borders of their own countries. Mental health is recognized as a key public health issue for conflict-affected populations. Studies revealed high levels of depression among IDPsAims of the studyThis study aims to identify the prevalence rate of depression among IDPs who left their homes after the bombing of the Al-Askari Shrine in Samara and now are resettled in AL-Diwaniyah governorate.Also to study the prevalence rate of depression in relation with some socio- demographic variables (such as age, sex, marital status, …