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An Examination Of Benefits Between Massage Therapy And Mental Health, Alexis Fears May 2024

An Examination Of Benefits Between Massage Therapy And Mental Health, Alexis Fears

University Honors College

Mental health affects millions of people every year, which is why finding effective treatment methods are important. This paper goes into a deep dive into the practice of massage therapy and its promising intervention for treated mental health disorders. Studies on the physiology of psychiatric disorders on the mental and physical states of the body will be reviewed. Following the examination of the effect the disorders have on the body, an examination of the effects of massage therapy on the physical and mental aspects of a psychiatric disorder will be provided. The findings show that massage therapy works to reduce …


A Systematic Review Of Mental Health Of Women In Fragile And Humanitarian Settings Of The Eastern Mediterranean Region, Fauziah Rabbani, Aysha Zahidie, Amna Siddiqui, Sanam Shah, Zul Merali, Khalid Saeed, Mohamed Afifi May 2024

A Systematic Review Of Mental Health Of Women In Fragile And Humanitarian Settings Of The Eastern Mediterranean Region, Fauziah Rabbani, Aysha Zahidie, Amna Siddiqui, Sanam Shah, Zul Merali, Khalid Saeed, Mohamed Afifi

Brain and Mind Institute

Background: The increasing emergencies and humanitarian challenges have worsened the mental health condition of women in the Eastern Mediterranean Region.

Aim: To assess the prevalence, determinants and interventions to address mental health among women in fragile and humanitarian settings in the Eastern Mediterranean Region.

Methods: Using the Preferred Reporting Items for Systematic Review and Meta-analysis guidelines, we reviewed 59 peer-reviewed published studies (PubMed, IMEMR) and grey literature (WHO/IRIS) from January 2001 to February 2023, focusing on women's mental health in the Eastern Mediterranean Region. We then conducted a descriptive analysis of the sociodemographic characteristics.

Results: Among …


Heartache Beyond The Physical: Unraveling The Nexus Between Myocardial Infarction History And Depressive Disorders In Us Adults, Sonika Khanal May 2024

Heartache Beyond The Physical: Unraveling The Nexus Between Myocardial Infarction History And Depressive Disorders In Us Adults, Sonika Khanal

Capstone Experience: Master of Public Health

Objective: To estimate the prevalence of depressive disorders among US adults and explore the association between a history of Myocardial Infarction (MI) and depressive disorders, considering potential risk factors and demographic variables.

Methods: A cross-sectional study was conducted from 2022 Behavioral Risk Factor Surveillance System data, including 390,429 US adults. Logistic regression was used to estimate the association between the history of MI and depressive disorders, adjusting for age, gender, race, smoking status, health insurance, education level, and BMI. Effect modification by age was assessed.

Results: The prevalence of depressive disorders was 21.19%, with 4.46% reporting a …


Role Of Proneurotrophin-P75ntr Signaling In A Mouse Model Of Depression, Kirsten Hodgson May 2024

Role Of Proneurotrophin-P75ntr Signaling In A Mouse Model Of Depression, Kirsten Hodgson

All Graduate Theses and Dissertations, Fall 2023 to Present

Major depressive disorder, or depression, is among the leading causes of disability globally. Despite being a large public health challenge, depression remains difficult to treat as the underlying biology is still unknown and the currently available treatments are limited in effectiveness. This experiment was to test the efficacy of the drug LM11A-31, which works on the signaling pathway of proneurotrophin-p75NTR, a pathway that is not targeted by any currently used antidepressants. Male mice underwent a repeated forced swim, with all the mice receiving saline the first two days and then half the mice receiving saline and half receiving LM11A-31 before …


The Aftermath Of The Pandemic’S Effect On College Student Depression, Lorena Sedano May 2024

The Aftermath Of The Pandemic’S Effect On College Student Depression, Lorena Sedano

Electronic Theses, Projects, and Dissertations

The present study examines how stress from the aftermath of the pandemic has affected college student depression. Using qualitative methods, ten college students voluntarily participated in recorded interviews. During these interviews students shared how the return to normality affected their experiences with depression, and the experiences of other students on campus. The study examined coping mechanisms to their adaptations, student’s individual stories, the effects that were viewed on campus, and their experiences during this transition. Students also completed the PHQ-2 and brief questions from the perceived stress scale. During the completion of the PHQ-2, 60% of students reported to have …


Covid-19, Social Isolation, And Msw Students’ Mental Health, Cassandra Barajas May 2024

Covid-19, Social Isolation, And Msw Students’ Mental Health, Cassandra Barajas

Electronic Theses, Projects, and Dissertations

New literature has found that the COVID-19 pandemic has grown the prevalence of anxiety and depression amongst college students (University Communications, 2021). The purpose of this research study was to further explore how the sudden restrictions and isolation protocols enforced and caused by the COVID-19 pandemic affected the mental health symptoms amongst MSW students. The study sample consisted of social work students who were 18 years old or older and who were enrolled in a Master of Social Work Program at some point in time during the COVID-19 pandemic period.

This study was conducted using a post-positivism approach and by …


An Exploration Of The Efficacy Of Virtual Agents Within Smartphone Mental Health Applications, Stephanie Six May 2024

An Exploration Of The Efficacy Of Virtual Agents Within Smartphone Mental Health Applications, Stephanie Six

All Dissertations

The prevalence of depression in the U.S. has increased over the past decade, leading to an all-time-high during the COVID-19 pandemic (WHO, 2022). With this increase, the number of mental health applications (MHealth apps) on virtual e-stores increases in tandem. Despite this expanding number of MHealth apps, few demonstrate a foundation in empirical research. One design factor that may influence usability and effectiveness is the inclusion of virtual agents. Three studies were conducted to investigate users’ preferences for a variety of characteristics associated with virtual agents. In Experiment 1, users completed a single-session, three-stage CBT-based interaction with virtual characters and …


The Effect Of Crime On Mental Health In South Africa, Magda Tsaneva, Lauren-Kate Laplante May 2024

The Effect Of Crime On Mental Health In South Africa, Magda Tsaneva, Lauren-Kate Laplante

Economics

This paper examines the impact of district-level crime rates in South Africa on individual depression symptoms. We use panel data from the National Income Dynamics Survey collected between 2008 and 2014 and estimate an individual fixed effects regression model, thus controlling for characteristics of the individual's environment that could affect crime and mental health. We find that an increase of one standard deviation in property (violent) crime is associated with a 7.2 (8.7) percentage point increase in the probability of depression symptoms. Analysis of potential mechanisms suggests that indirect exposure to crime likely affects mental health by increasing stress rather …


Navigating Mental Health During Covid-19: Considerations Of Childhood Adversity, Pandemic Stress, And Loneliness, Linnea Rose Swanson May 2024

Navigating Mental Health During Covid-19: Considerations Of Childhood Adversity, Pandemic Stress, And Loneliness, Linnea Rose Swanson

Dissertations and Doctoral Documents, University of Nebraska-Lincoln, 2023–

The purpose of this dissertation study was twofold. First, to determine if the addition of bullying victimization to the Adverse Childhood Experiences (ACEs) Questionnaire (Felitti et al., 1998) would result in a stronger measure of childhood adversity; second to examine the interaction between ACEs, pandemic stress, loneliness, and internalizing symptoms in a sample of young adults living in the United States during the COVID-19 pandemic. ACEs are linked to negative outcomes in adulthood including mental health problems, stress, and loneliness. During the pandemic, increased levels of stress and loneliness were associated with higher rates of internalizing disorders among young adults. …


Mental Health Awareness In Adolescents And The Impact Of Social Media, Vanessa Clark May 2024

Mental Health Awareness In Adolescents And The Impact Of Social Media, Vanessa Clark

Capstone Projects and Master's Theses

This capstone project focuses on informing parents of the effects of social media on adolescents’ mental health. Adolescents are frequent users of social media as they are more likely to explore online content and be unaware of the potential dangers that can pose a threat to their mental health (Rapee et al. 2019). Due to social media being difficult to monitor at all times, along with advances in technology through school curriculums, we want to acknowledge its presence and usage. Social media allows the opportunity to connect with others digitally but there needs to be awareness of the potentially harmful …


A Randomized Trial Of Two Remote Health Care Delivery Models On The Uptake Of Genetic Testing And Impact On Patient-Reported Psychological Outcomes In Families With Pancreatic Cancer: The Genetic Education, Risk Assessment, And Testing (Generate) Study, Nicolette J Rodriguez, C Sloane Furniss, Matthew B Yurgelun, Chinedu Ukaegbu, Pamela E Constantinou, Ileana Fortes, Alyson Caruso, Alison N Schwartz, Jill E Stopfer, Meghan Underhill-Blazey, Barbara Kenner, Scott H Nelson, Sydney Okumura, Alicia Y Zhou, Tara B Coffin, Hajime Uno, Miki Horiguchi, Allyson J Ocean, Florencia Mcallister, Andrew M Lowy, Alison P Klein, Lisa Madlensky, Gloria M Petersen, Judy E Garber, Scott M Lippman, Michael G Goggins, Anirban Maitra, Sapna Syngal May 2024

A Randomized Trial Of Two Remote Health Care Delivery Models On The Uptake Of Genetic Testing And Impact On Patient-Reported Psychological Outcomes In Families With Pancreatic Cancer: The Genetic Education, Risk Assessment, And Testing (Generate) Study, Nicolette J Rodriguez, C Sloane Furniss, Matthew B Yurgelun, Chinedu Ukaegbu, Pamela E Constantinou, Ileana Fortes, Alyson Caruso, Alison N Schwartz, Jill E Stopfer, Meghan Underhill-Blazey, Barbara Kenner, Scott H Nelson, Sydney Okumura, Alicia Y Zhou, Tara B Coffin, Hajime Uno, Miki Horiguchi, Allyson J Ocean, Florencia Mcallister, Andrew M Lowy, Alison P Klein, Lisa Madlensky, Gloria M Petersen, Judy E Garber, Scott M Lippman, Michael G Goggins, Anirban Maitra, Sapna Syngal

Faculty, Staff and Student Publications

Background & aims: Genetic testing uptake for cancer susceptibility in family members of patients with cancer is suboptimal. Among relatives of patients with pancreatic ductal adenocarcinoma (PDAC), The GENetic Education, Risk Assessment, and TEsting (GENERATE) study evaluated 2 online genetic education/testing delivery models and their impact on patient-reported psychological outcomes.

Methods: Eligible participants had ≥1 first-degree relative with PDAC, or ≥1 first-/second-degree relative with PDAC with a known pathogenic germline variant in 1 of 13 PDAC predisposition genes. Participants were randomized by family, between May 8, 2019, and June 1, 2021. Arm 1 participants underwent a remote interactive telemedicine session …


Implementation Of Prenatal And Postpartum Depression Screening For A Telehealth Company, Allison Herrmann, Lori Deibel May 2024

Implementation Of Prenatal And Postpartum Depression Screening For A Telehealth Company, Allison Herrmann, Lori Deibel

Doctor of Nursing Practice Projects

Abstract

Depression is a leading mental health disorder. Depression occurring during the perinatal and postpartum periods has become highly prevalent throughout the world, impacting 5-10% of women during (van de Loo et al., 2018) and 9-23.5% postpartum (Bauman et al., 2020). Proper diagnosis and treatment of perinatal and postpartum depression (PPD) is crucial, as depression can lead to poor outcomes including relationship complications and negatively affect child development (Slomain, 2019). The implementation of screening tools can help identify women at risk based on their signs and symptoms of PPD (Bauman et al., 2020). The primary goal of this project was …


Single Case Experimental Design Examining Cognitive Behavioural Therapy For Post-Stroke Depression, Liam Alexander Mackenzie Myles, Emma Jones Apr 2024

Single Case Experimental Design Examining Cognitive Behavioural Therapy For Post-Stroke Depression, Liam Alexander Mackenzie Myles, Emma Jones

Journal of Mind and Medical Sciences

Background. Post-stroke depression (PSD) is common in older-age adults and is typically treated with cognitive-behavioural therapy (CBT). However, research has ascertained mixed findings regarding the efficacy of CBT for PSD in older-age adults, with limited evidence in people from global majority backgrounds. Materials and Methods. This case study used single case experimental design methodology to examine the effectiveness of CBT for PSD in a black, older-age man. The effects of health conditions, cohort beliefs, transitions in role investments, socio-cultural context and early experiences on the client’s thoughts, emotions, physical sensations and behaviours were formulated, before behavioural activation was used to …


Suicidal Ideation In Malaysian Young Adults: The Role Of Depressive Symptoms And Perceived Problem-Solving Ability, Shin Ling Wu, Yong Chy Sin Apr 2024

Suicidal Ideation In Malaysian Young Adults: The Role Of Depressive Symptoms And Perceived Problem-Solving Ability, Shin Ling Wu, Yong Chy Sin

Makara Journal of Health Research

Background: The escalating suicide rates among young adults, including those in Malaysia, necessitate a deeper understanding of the factors contributing to suicidal ideation. This study investigates the relationship between depressive symptoms and perceived problem-solving ability, including problem-solving confidence, approach-avoidance style, personal control of emotion, and suicidal ideation among Malaysian young adults.

Methods: A total of 231 Malaysian young adults aged 18 to 25 years (Mean = 21.1; SD = 1.38) participated in a cross-sectional survey study. The sample was primarily composed of participants of Chinese ethnicity. Using an online survey, participants completed measures including the Depression, Anxiety, and …


The Effectiveness Of Weighted Blankets As A Sleep Promoting Behavior: A Quasi -Experimental Study, Irish Amalia, Sali R. Asih, Inge U. Wiswanti, Ina Saraswati Apr 2024

The Effectiveness Of Weighted Blankets As A Sleep Promoting Behavior: A Quasi -Experimental Study, Irish Amalia, Sali R. Asih, Inge U. Wiswanti, Ina Saraswati

Psychological Research on Urban Society

Sleep is crucial to the overall well-being of individuals. Sleep deficiency can lead to various physical and mental health issues, including more severe insomnia, anxiety, and depressive symptoms. Improving sleep quality is often emphasized through sleep hygiene. An emerging nonpharmacological intervention is the use of weighted blankets, which apply deep-pressure stimulation to promote feelings of relaxation, comfort, and security similar to a gentle hug. This study explored the effects of weighted blankets on sleep quality and symptoms of insomnia, anxiety, and depression. Thirty participants (M = 33 years, SD = 9.13) used weighted blankets for 14 nights. They completed the …


Nurse Suicide: Examining Depression And Anxiety In Critical Care Settings, Arianna Bernardine Barata Apr 2024

Nurse Suicide: Examining Depression And Anxiety In Critical Care Settings, Arianna Bernardine Barata

Nursing | Student Research Posters

Nurses play a critical role in healthcare, yet the demanding work environment often exposes them to stressors, leading to the development of depression and anxiety. According to the National Library of Medicine (NLM) (2021), 50.8% of nurses have stress, 74% have anxiety, 70.8% have depression, and 79.1% have at least one of them. Burnout, understaffing, COVID fatigue, alarm fatigue, patient ratios, and disrupted sleep patterns are some of the stressors nurses contend with in every shift. While some nurses may cope and overcome these challenges, many face more severe issues, such as suicide. Nurse suicide is an issue that has …


Examining The Effect Of Genes On Depression As Mediated By Smoking And Modified By Sex, Kirsten Voorhies, Julian Hecker, Sanghun Lee, Georg Hahn, Dmitry Prokopenko, Merry-Lynn Mcdonald, Alexander C Wu, Ann Wu, John E Hokanson, Michael H Cho, Christoph Lange, Karin F Hoth, Sharon M Lutz Apr 2024

Examining The Effect Of Genes On Depression As Mediated By Smoking And Modified By Sex, Kirsten Voorhies, Julian Hecker, Sanghun Lee, Georg Hahn, Dmitry Prokopenko, Merry-Lynn Mcdonald, Alexander C Wu, Ann Wu, John E Hokanson, Michael H Cho, Christoph Lange, Karin F Hoth, Sharon M Lutz

Faculty, Staff and Student Publications

Depression is heritable, differs by sex, and has environmental risk factors such as cigarette smoking. However, the effect of single nucleotide polymorphisms (SNPs) on depression through cigarette smoking and the role of sex is unclear. In order to examine the association of SNPs with depression and smoking in the UK Biobank with replication in the COPDGene study, we used counterfactual-based mediation analysis to test the indirect or mediated effect of SNPs on broad depression through the log of pack-years of cigarette smoking, adjusting for age, sex, current smoking status, and genetic ancestry (via principal components). In secondary analyses, we adjusted …


Educational Campaign: Using Exercise To Prevent Postpartum Depression, Ruth Platt Apr 2024

Educational Campaign: Using Exercise To Prevent Postpartum Depression, Ruth Platt

MSN Capstone Projects

Postpartum depression is one of the most common medical ailments surrounding childbirth. It affects up to 20% of postpartum women and has detrimental effects not only on the mother but her infant and family as well (Navas et al., 2021). Currently, the medical community takes a reactive approach to postpartum depression by screening and treating cases of postpartum depression as they occur. An evidence-based search of peer-reviewed articles found that exercise in the perinatal period had a positive effect on maternal mental health and decreased postpartum depression scores. This is especially true for women who have a history of depression …


Exploring How Pentecostals Preach About Depression, Robert D. Mcbain Apr 2024

Exploring How Pentecostals Preach About Depression, Robert D. Mcbain

Salubritas: International Journal of Spirit-Empowered Counseling

A qualitative analysis was completed on twelve sermons into how Pentecostal preachers talk about depression from the pulpit using the Assemblies of God (AG) as a purposive sample. Findings illustrate that preachers talked about faulty thinking as the source of depression and interpreted depression as a transformative journey occurring within the context of a God encounter where the believer fixed their faulty thinking. While the way the preachers interpreted depression is not without critique, the article suggests that preaching about depression as a journey of encounter may help listeners frame their depression experiences within a narrative framework that helps them …


Impact Of Parental Spirituality On Child Depression, Anxiety, And Ptsd After A Surgical Procedure, Ashlee M. Schendel Apr 2024

Impact Of Parental Spirituality On Child Depression, Anxiety, And Ptsd After A Surgical Procedure, Ashlee M. Schendel

Honors Thesis

Higher levels of religiosity and spirituality (R/S) have been associated with lower levels of depressive symptoms (Lucchetti, Koenig, & Lucchetti, 2021; Braam & Koenig, 2019). While it is unknown why the relationship exists, it may be a result of the social support obtained from attending a place of worship (Gwin et al., 2020). The relationship between anxiety and R/S is far more mixed, with studies having found both positive and negative correlations (Lucchetti, Koenig, & Lucchetti, 2021). It is theorized spirituality may be used to cope with anxiety both negatively (e.g., God hates me) and positively (e.g., God wants to …


Evaluating The Efficacy Of Universal Depression Screenings In The High School Setting, Telisha Anthony Msn, Fnp-Bc, Jennifer Thorsen Bsn, Rn, Jackie Sharp Dnp, Pmhnp-Bc, Sharon Little Dnp, Fnp-Bc Apr 2024

Evaluating The Efficacy Of Universal Depression Screenings In The High School Setting, Telisha Anthony Msn, Fnp-Bc, Jennifer Thorsen Bsn, Rn, Jackie Sharp Dnp, Pmhnp-Bc, Sharon Little Dnp, Fnp-Bc

Doctor of Nursing Practice Projects

Purpose/Background

Depression in adolescents is rising each year. Early detection of depression has been shown to result in better health outcomes and success in school. This scoping review aims to evaluate the implementation of universal depression screenings in the high school setting and how this detection of depression and initiation of treatment.

Methods

From August 2022 to November 2023, we used the Medline, PubMed, Elsevier, Google Scholar, and PsycINFO databases, using specific keywords related to depression in adolescents. Of the 38 articles found, 10 were chosen after extensive article critique. The publication dates ranged from 2014-2023, were full-text, and from …


Implementing Universal Adult Depression Screening In A Rural Maine Free Medical Clinic, Karen Hussion Apr 2024

Implementing Universal Adult Depression Screening In A Rural Maine Free Medical Clinic, Karen Hussion

Doctor of Nursing Practice Scholarly Projects

Abstract

BACKGROUND: Depression in adults is a leading cause of disability, morbidity and mortality worldwide with an estimated prevalence of 20% in the US population. Despite estimates that one out of every five Americans suffers from depression, less than 50% of adult primary care patients with depression are identified, and less than 5% of all adult primary care patients are screened. To increase early detection and management of depression, the United States Protective Service Task Force (USPSTF) recommends routine depression screening for adults older than 18 years in primary care settings.

LOCAL PROBLEM: This project site was a rural, free, …


When They Just Don’T Sleep: Differential Impacts Of Reduced Child Sleep On Depression, Anxiety, And Stress Among Caregivers Of Children With And Without Neurogenetic Syndromes, Kimberly Galvez-Ortega, Kristine Marceau, Dan Foti, Bridgette Kelleher Apr 2024

When They Just Don’T Sleep: Differential Impacts Of Reduced Child Sleep On Depression, Anxiety, And Stress Among Caregivers Of Children With And Without Neurogenetic Syndromes, Kimberly Galvez-Ortega, Kristine Marceau, Dan Foti, Bridgette Kelleher

Purdue University Libraries Open Access Publishing Fund

Introduction: Children with neurogenetic syndromes commonly experience significant and pervasive sleep disturbances, however, associations with caregiver mental health remains unclear. Previous studies have linked sleep disturbances with increased caregiver depression in typically developing populations, and heightened caregiver stress among neurogenetic populations. The present study expands on findings by exploring the longitudinal association between child sleep duration and caregiver mental health (depression, anxiety, stress) throughout development (infancy to school-aged children) in dyads with and without a child affected by a neurogenetic syndrome.

Methods: Participants were drawn from the Purdue Early Phenotype Study, including 193 caregivers (Age: M = 34.40 years, SD …


Depression And Other Risk Factors Of Suicide, Mckenna Newnam, Jaeyong Choi Apr 2024

Depression And Other Risk Factors Of Suicide, Mckenna Newnam, Jaeyong Choi

Criminal Justice Student Work

Substance abuse, other mental disorders, and individual characteristics all play a role in the risk of suicide when concurrent with depression. Far more research exists on depression as it effects suicide alone. Future research needs to focus on depression as it effects suicide and explore the other possible factors that can impact the outcome. Understanding the different aspects of depression as it effects suicide will provide a template for scholars and individuals involved in the mental health system to enhance treatment.


Stroke-Related Mental Health Challenges And Interventions: Strategies For Holistic Recovery, Christopher Walsh, Sam Lee Apr 2024

Stroke-Related Mental Health Challenges And Interventions: Strategies For Holistic Recovery, Christopher Walsh, Sam Lee

MOT Student Capstones

This capstone project examines the relationship between post-stroke and mental health. It presents the necessity for a holistic and client-centered approach in the recovery process. Through a mixed-methods approach combining a literature review and empirical research, including surveys of stroke survivors, caregivers, and practitioners, the study shows the prevalence of depression and anxiety post-stroke and the potential benefit of comprehensive mental health support. The findings emphasize the importance of community, spirituality, and proactive education in enhancing mental well-being. The effectiveness of specific interventions for this population was found to be variable, which warrants the use of personalized assessments and intervention …


My Journey In Researching Depression Among Black People: Experiences Of A Researcher In A Sensitive Study, Brightness L. Kgatla Apr 2024

My Journey In Researching Depression Among Black People: Experiences Of A Researcher In A Sensitive Study, Brightness L. Kgatla

The Qualitative Report

The interest in qualitative research on mental health within Black communities is rapidly growing. However, there are still debates on the conceptualization of depression among the Black community. This paper focuses on the researcher’s experiences as a young Black South African experiencing depression, and their reflections on interpretivist qualitative research focused on the realities of Black South African youth experiencing depression. The paper highlights the importance of reflexivity in a qualitative study and how the topics researched by a Black South African experiencing depression which is still considered a taboo within some parts of the Black community. If a researcher …


Effects Of Electrical Exercise On Self-Reported Depression And Quality Of Life In Those With Spinal Cord Injury, Aj Barber, Eric Heidorn, John Mcdaniel, Cody S. Dulaney Apr 2024

Effects Of Electrical Exercise On Self-Reported Depression And Quality Of Life In Those With Spinal Cord Injury, Aj Barber, Eric Heidorn, John Mcdaniel, Cody S. Dulaney

International Journal of Exercise Science: Conference Proceedings

One of the most common psychological disorders that occur as a result of spinal cord injury (SCI) is depression along with reductions in quality of life. Moreover, depression is correlated with quality of life. It is increasingly apparent that exercise offers an accessible and non-pharmacological intervention to ease depressive symptoms and improve quality of life. Unfortunately, access to meaningful exercise options remains challenging to those with mobility impairments such as those seen with SCI. PURPOSE: The purpose of this study was to assess the chronic engagement of home-based electrical stimulation exercise (ESE) on self-reported depression and quality of life …


Individual Differences In Cannabis Use Disorder With Implications For Endocannabinoid Modulation In Therapeutics Development, Erin L. Martin Apr 2024

Individual Differences In Cannabis Use Disorder With Implications For Endocannabinoid Modulation In Therapeutics Development, Erin L. Martin

MUSC Theses and Dissertations

Cannabis use disorder (CUD) is increasingly prevalent in the United States, but there is no effective pharmacological means to treat it. The endocannabinoid (eCB) system has emerged as a candidate therapeutic target demonstrating some evidence of efficacy in treating CUD. However, clinical trials evaluating eCB-modulating therapeutics have historically undervalued individual differences that could contribute to variation in treatment outcome (e.g. sex, comorbid psychiatric illness). To address this gap in the literature, the present set of studies (a) compared plasma eCB tone in groups underrepresented in treatment trials for CUD (females, individuals with comorbid major depressive disorder; MDD/CUD) with males or …


Abnormal Neural Sensitivity To Rewards As A Candidate Process Of High Depression Risk In The Fmr1 Premutation: A Pilot Study, Roslyn Harold, Bridgette Kelleher, Keisha Novak, Wei Siong Neo, Teagan Stump, Taylor Lee, Tessa Garwood, Elizabeth Berry-Kravis, Dan Foti Apr 2024

Abnormal Neural Sensitivity To Rewards As A Candidate Process Of High Depression Risk In The Fmr1 Premutation: A Pilot Study, Roslyn Harold, Bridgette Kelleher, Keisha Novak, Wei Siong Neo, Teagan Stump, Taylor Lee, Tessa Garwood, Elizabeth Berry-Kravis, Dan Foti

Purdue University Libraries Open Access Publishing Fund

The etiological heterogeneity of depression poses a challenge for prevention and intervention efforts. One solution is to map unique etiological pathways for subgroups defined by a singular risk factor. A relevant population for this approach is women who carry the premutation of the fragile X messenger ribonucleoprotein 1 (FMR1) gene, who are at high risk for adult-onset depression. This study explores a candidate neurophysiological marker of depression risk: reduced reward sensitivity, indexed by the reward positivity (RewP). The RewP has been linked to depression risk in the general population, but is unexplored within FMR1 premutation carriers. 16 women with the …


Perioperative Mental Health Intervention For Depression And Anxiety Symptoms In Older Adults Study Protocol: Design And Methods For Three Linked Randomised Controlled Trials, Katherine J Holzer, Kimberly A Bartosiak, Ryan P Calfee, Chet W Hammill, Simon Haroutounian, Benjamin D Kozower, Theresa A Cordner, Emily M Lenard, Kenneth E Freedland, Bethany R Tellor Pennington, J Philip Miller, Mary C Politi, Yi Zhang, Michael D Yingling, Ana A Baumann, Thomas Kannampallil, Julia A Schweiger, Sherry L Mckinnon, Michael S Avidan, Eric J Lenze, Joanna Abraham, Et Al. Apr 2024

Perioperative Mental Health Intervention For Depression And Anxiety Symptoms In Older Adults Study Protocol: Design And Methods For Three Linked Randomised Controlled Trials, Katherine J Holzer, Kimberly A Bartosiak, Ryan P Calfee, Chet W Hammill, Simon Haroutounian, Benjamin D Kozower, Theresa A Cordner, Emily M Lenard, Kenneth E Freedland, Bethany R Tellor Pennington, J Philip Miller, Mary C Politi, Yi Zhang, Michael D Yingling, Ana A Baumann, Thomas Kannampallil, Julia A Schweiger, Sherry L Mckinnon, Michael S Avidan, Eric J Lenze, Joanna Abraham, Et Al.

2020-Current year OA Pubs

INTRODUCTION: Preoperative anxiety and depression symptoms among older surgical patients are associated with poor postoperative outcomes, yet evidence-based interventions for anxiety and depression have not been applied within this setting. We present a protocol for randomised controlled trials (RCTs) in three surgical cohorts: cardiac, oncological and orthopaedic, investigating whether a perioperative mental health intervention, with psychological and pharmacological components, reduces perioperative symptoms of depression and anxiety in older surgical patients.

METHODS AND ANALYSIS: Adults ≥60 years undergoing cardiac, orthopaedic or oncological surgery will be enrolled in one of three-linked type 1 hybrid effectiveness/implementation RCTs that will be conducted in tandem …