Digital Commons Network^™

An Audit Of Diabetes-Dependent Quality Of Life And Glycemic Control Among Type 2 Diabetes Patients In A Tertiary Hospital In Bangkok: A Hospital-Based Cross-Sectional Study, Nattaya Tungsirikoon, Nopporn Howteerakul, Nawarat Suwannapong, Petch Rawdaree

Journal of Health Research

Background: This hospital-based cross-sectional study aimed to examine the association between diabetes-specific quality of life (QoL), diabetes-related clinical characteristics and glycemic control among type 2 diabetes (T2DM) patients.

Methods: 335 T2DM patients receiving treatment at the diabetes clinic of a tertiary hospital in Bangkok, Thailand, were recruited into the study. The Audit of Diabetes-Dependent Quality of Life (ADDQoL19) was used to assess QoL. The ADDQoL scores were split into two groups using quartiles. The group in the lower quartile was considered as “having low QoL.” Hemoglobin A1c (A1C) was used as an index of glycemic control.

Results: 67.8% of participants …

The Novel Uncompetitive Nmda Receptor Antagonist Esmethadone (Rel-1017) Has No Meaningful Abuse Potential In Recreational Drug Users, Megan J Shram, Jack E Henningfield, Glen Apseloff, Charles W Gorodetzky, Sara De Martin, Frank L Vocci, Frank L Sapienza, Thomas R Kosten, Jeff Huston, August Buchhalter, Judy Ashworth, Ryan Lanier, Franco Folli, Andrea Mattarei, Clotilde Guidetti, Stefano Comai, Cedric O'Gorman, Sergio Traversa, Charles E Inturrisi, Paolo L Manfredi, Marco Pappagallo

Faculty, Staff and Students Publications

Esmethadone (REL-1017) is the opioid-inactive dextro-isomer of methadone and a low-affinity, low-potency uncompetitive NMDA receptor antagonist. In a Phase 2, randomized, double-blind, placebo-controlled trial, esmethadone showed rapid, robust, and sustained antidepressant effects. Two studies were conducted to evaluate the abuse potential of esmethadone. Each study utilized a randomized, double-blind, active-, and placebo-controlled crossover design to assess esmethadone compared with oxycodone (Oxycodone Study) or ketamine (Ketamine Study) in healthy recreational drug users. Esmethadone 25 mg (proposed therapeutic daily dose), 75 mg (loading dose), and 150 mg (Maximum Tolerated Dose) were evaluated in each study. Positive controls were oral oxycodone 40 mg …

Stress Reactivity After Pediatric Traumatic Brain Injury: Relation With Behavioral Adjustment, Taiane De Azevedo Cardoso, Ritele H Silva, Jessica L Fernandes, Camila O Arent, Graziela Amboni, Laura A Borba, Alex Paulo Z Padilha, Maria Eduarda M Botelho, Amanda L Maciel, Tatiana Barichello, Rodrigo Morales, Silvio José B Soares, Margarete D Bagatini, Claudia Dallagnol, Marta Elisa Brighenti, Zuleide Maria Ignácio, João Quevedo, Luciane B Ceretta, Gislaine Z Réus

Faculty, Staff and Student Publications

BACKGROUND: Although many studies have pointed out a possible relationship between COVID-19 and the presence of psychiatric disorders, the majority of the studies have significant limitations. This study investigates the influence of COVID-19 infection on mental health.

METHODS: This cross-sectional study included an age- and sex-matched sample of adult individuals positive (cases) or negative (controls) for COVID-19. We evaluated the presence of psychiatric conditions and C-reactive protein (CRP).

RESULTS: Findings showed greater severity of depressive symptoms, higher levels of stress, and greater CRP in cases. The severity of depressive and insomnia symptoms, as well as the CRP were more remarkable …

Influence Of Depression And Interpersonal Support On Adherence To Antiretroviral Therapy Among People Living With Hiv, Jerry John Nutor, Akua O. Gyamerah, Robert Kaba Alhassan, Henry Ofori Duah, Rachel G.A. Thompson, Natalie Wilson, Orlando Harris, Jose Gutierrez, Thomas J. Hoffmann, Monica Getahun, Glenn-Milo Santos

College of Nursing Faculty Research and Publications

Background

Poor adherence and under-utilization of antiretroviral therapy (ART) services have been major setbacks to achieving 95-95-95 policy goals in Sub-Saharan Africa. Social support and mental health challenges may serve as barriers to accessing and adhering to ART but are under-studied in low-income countries. The purpose of this study was to examine the association of interpersonal support and depression scores with adherence to ART among persons living with HIV (PLWH) in the Volta region of Ghana.

Methods

We conducted a cross-sectional survey among 181 PLWH 18 years or older who receive care at an ART clinic between November 2021 and …

Improvements In Physical Function And Pain Interference And Changes In Mental Health Among Patients Seeking Musculoskeletal Care, Wei Zhang, Som P Singh, Amdiel Clement, Ryan P Calfee, Janine D Bijsterbosch, Abby L Cheng

2020-Current year OA Pubs

IMPORTANCE: Among patients seeking care for musculoskeletal conditions, there is mixed evidence regarding whether traditional, structure-based care is associated with improvement in patients' mental health.

OBJECTIVE: To determine whether improvements in physical function and pain interference are associated with meaningful improvements in anxiety and depression symptoms among patients seeking musculoskeletal care.

DESIGN, SETTING, AND PARTICIPANTS: This cohort study included adult patients treated by an orthopedic department of a tertiary care US academic medical center from June 22, 2015, to February 9, 2022. Eligible participants presented between 4 and 6 times during the study period for 1 or more musculoskeletal conditions …

Increasing Life Skills While Decreasing Depression, Anxiety, And Stress In Transitional Aged Youth: A Person-Centered Mentorship Approach, Allanah Roberts-Headley

Dissertations

Transitional Aged Youth (TAYs) are young adults between 18-24 who have recently aged out of the foster care system and are now a part of the Extended Foster Care system (EFC). Unfortunately, this population is not guaranteed familial or social support. They have to rely on basic knowledge and skills obtained while in the foster care system to help with navigate their world. Most TAYs end up homeless, unemployed, and incarcerated. There is also a high pregnancy rate among TAYs. Due to the limited assistance they receive upon entering EFC, they are at a higher risk of experiencing mental health …

Experiences And Perspectives Of Children And Young People Living With Childhood-Onset Systemic Lupus Erythematosus—An Integrative Review, Julie Blamires, Mandie Foster, Sara Napier, Annette Dickinson

Research outputs 2022 to 2026

Childhood-onset systemic lupus erythematosus (cSLE) impacts the daily life of children and young people. This study aimed to describe the experiences and perspectives of children and young people living with cSLE. An integrative review guided by Whittemore and Knafl was conducted. Extant empirical research published in peer-reviewed journals from 2000 to 2021 on children’s self-reported experiences living with cSLE was identified from Scopus, CINAHL, Medline via PubMed, and PsycINFO via Ovid databases. Nineteen studies involving over 1400 participants were included. Four themes and fourteen sub-themes were identified: (1) challenging symptoms (disruptions to life and altered self, severity, fatigue, depression, and …

Nurse-Led Post Stroke Depression Screening (Psd) For Patients With Acute Stroke Using Patient Health Questionnaire-9 (Phq9), Stefan Panov

Doctor of Nursing Practice Final Manuscripts

Introduction: This Evidence-Based Practice Doctor of Nursing Practice project aimed to implement a nurse-led post-stroke depression (PSD) screening using Patient Health Queastionnaire-9 (PHQ-9) in a 12-bed progressive care neuro-stroke unit at a tertiary care hospital. The first goal of this project was to detect stroke patients at risk for depression who met specific inclusion criteria. The second goal was to provide depression education, initiate social work and medical referrals, and start pharmacological treatment to reduce the medical and socioeconomic burden associated with untreated PSD before discharge from the hospital.

Background: Globally, stroke is a prominent cause of death and disability. …

Designing A Coloring Book As A Tool To Introduce Mindfulness-Based Stress Reduction (Mbsr), Billie Beth Charles

Critical and Creative Thinking Capstones Collection

This paper explores the design process of developing an illustrated coloring book, as a tool to introduce Mindfulness-Based Stress Reduction (MBSR) techniques to young adults experiencing heightened levels of anxiety, panic, and depression. The MBSR coloring book, is being developed based on a theory, and supporting evidence, that engaging in an artistic activity like coloring, can make MBSR techniques accessible to young adults seeking help for anxiety and panic-related symptoms. The author discusses the challenges young adults face in the current societal context and highlights the need for effective and accessible strategies to manage mental health issues. Through research, experience, …

Exercise As A Prescription For Patients With Depressive Disorders: A Quality Improvement Project, Sydney Roscoe, Rachelle Pace

Doctor of Nursing Practice Final Manuscripts

Purpose: The aim of this Doctor of Nursing Practice project was to increase exercise counseling rates in the treatment of depression by (1) implementing a focused educational training program and (2) understanding factors that impacted utilization of the practice change.

Background: Approximately 280 million individuals suffer globally from depressive disorders. Depression remains the fourth leading cause of disabilities, significantly contributing toward the global burden of disease by increasing morbidity and mortality risk. Psychopharmacology and psychotherapy are current gold standards of treatment; however, providers often overlook the significant role exercise serves in reducing depressive symptoms and severity, as it remains underutilized. …

Writing As A Mode Of Therapy: The Path To Healing And Selfcare, Lolita Joyce Law

Masters Theses

When someone is plunging into a deep depression, they may not know what to do with the next moment in their lives. All they do know is that they would like the pain to stop. There are many modes of therapy used to assist people with healing. However, writing for many has the most rewards. It is an expression that allows the individual writing to dig much deeper than any spoken word could allow. Writing can help clear, evaluate, and purge the mind of negative thoughts before it leads to action. Poetry, journaling, and songwriting are just a few methods …

From Rags To Riches: Examining Teacher Perceptions Of The Influence Of Financial Literacy On The Psychological Well-Being Of Military-Connected Students In Kindergarten Through Grade Twelve, Cynthia Fletcher Davis

Doctoral Dissertations and Projects

The purpose of this quantitative study was to examine teacher perceptions as related to the influence of financial literacy on the psychological well-being of military-connected students in kindergarten through grade twelve. Financial literacy among students serves a vital function in the development of financially literate adults. A lack of financial resources has been linked to depressive symptoms, marital discourse, and suicide. Financial literacy includes the knowledge and skills required to make enlightened and effective decisions with money. The theory guiding this study was Constructivism as formulated by Jean Piaget. Constructivism provides for the incorporation of new information within existing constructs …

The Effects Of Therapeutic Activities On Depression In The Long-Term Care Population, Stephanie Nacole Knowles

Doctoral Dissertations and Projects

Therapeutic activities are activities that encourage social interaction and promote cognitive skills. When these activities are put on hold for an extended period of time it can be detrimental to the Long-Term Care population. Depression related to social isolation has plagued the LongTerm Care population since the onset of COVID, causing increased sickness and in some situations death. The purpose of this integrative review is to determine the effectiveness of therapeutic activities in decreasing depression in the Long-Term Care (LTC) population. Literature was collected from 2018 through 2023 from the CINAHL database and analyzed using the PRISMA model. A total …

A Clinical N Of 1 Time Series On The Efficacy Of Internal Family Systems And Christian Inner Healing Prayer With Adult Survivors Of Childhood Trauma, Kharma K. Parker

Doctoral Dissertations and Projects

Internal Family Systems (IFS) is a non-pathologizing psychospiritual therapeutic model in which “all parts are welcome.” Christian Inner Healing Prayer (CIHP) is an intervention that invites an authentic experience with the Divine to address inner wounds. Both methods are touted as beneficial to clients with trauma histories. However, IFS is an evidenced based treatment while only preliminary research on CIHP has been done. Several efforts to create a Christian cultural accommodation of IFS have been authored; two implicitly reference CIHP. None have been researched. This study is an N of 1 time series study of the efficacy of IFS with …

The Impact Of Changes In Religion On Health Among Sexual Minority Mormons, G. Tyler Lefevor, Samuel J. Skidmore, Kiet D. Huynh, James S. Mcgraw

Psychology Faculty Publications

The current study presents data from the first longitudinal examination of sexual minority (SM) Mormons (n = 132). Over the course of 2 years, SM Mormons reported decreased psychological (e.g., orthodox beliefs), behavioral (e.g., service attendance), and social (interpersonal religious commitment) religiousness. Analyses revealed that, at baseline, service attendance was related to lower levels of meaning in life and higher levels of depression at time 2, while interpersonal religious commitment at baseline was related to higher levels of meaning in life and lower levels of depression. Latent change scores of religiousness suggested that decreases in interpersonal religious commitment over …

Bibliotherapy With Children With Neurodiverse Profiles: A Literature Review, Jessica Piltch-Loeb

Expressive Therapies Capstone Theses

Expressive arts therapy interventions are continuing to gain recognition as a means of healing for individuals with a wide range of diagnoses. Bibliotherapy is a particularly under researched modality of the expressive arts, leaving ample opportunity for future research on both reading and writing interventions. While bibliotherapy may not be a widespread subject of study, preliminary research shows that reading and writing therapies can promote emotional well-being for individuals dealing with mental illness. Children with neurodiverse profiles (NP) are more likely to be diagnosed with psychiatric disorders such as depression, anxiety, bipolar disorder, and schizophrenia, than neurotypical children. Although previous …

The Development Of A Dance/Movement Therapy Method For Social Engagement With Adolescents In A Partial Hospital Program, Kayleah Pensalfini

Expressive Therapies Capstone Theses

Mental health can significantly impede navigating the social domain during adolescence. Research has indicated social development of adolescents may be impacted by psychopathology and emotional development, further hindering one’s formation of self. There is also limited research showing the effectiveness of Dance/Movement Therapy (DMT) with the adolescent population. This writer designed and adapted one DMT session for adolescents to understand this topic better. This capstone will present an adaptable method utilizing a DMT intervention with participants between the ages of 13-17 in a Partial Hospital Program (PHP). This project aimed to examine how DMT can support self-identity and the acquisition …

Mental Health Among D1 Female College Athletes: Prevalance And Links To Athletic And Academic Performance, Mary Goebel

Honors Theses

Background. NCAA Division I female student-athletes are underrepresented in mental health research; existing research among female athletes tends to focus only on disordered eating and body appearance. This study aims to 1) describe the prevalence of mental health issues (i.e., anxiety, depression, and stress) among female Division I college athletes, and 2) assess the association between mental health issues and the student-athlete experience (i.e., athletic and academic performance).

Methods. This was a quantitative, cross-sectional study that used a self-administered online survey. The participants were NCAA Division I female student-athletes, mainly from the University of Mississippi. Demographics and sample characteristics were …

Associations Between Tiktok Use, Mental Health, And Body Image Among College Students, Alexz Carpenter

Honors Theses

Background. Social media use continues to increase globally, and there is a large field of research examining the relationships between social media use with anxiety, depression, and body image. College-aged students are particularly vulnerable to these associations because they are at a unique developmental point of their life. College-aged students also use social media more frequently than almost any other age group, which may put them at increased risk for negative mental health and body image outcomes related to their social media use. TikTok is a relatively new social media app that has exponentially risen in popularity, especially among younger …

Analyzing The Unique Role Of Repetitive Negative Thinking On Insomnia In College Students, Lara Fair

Honors Theses

Repetitive negative thinking is a transdiagnostic construct that conceptually covers worry and rumination, which are strongly associated with anxiety and depression. Worry is typically future oriented, whereas rumination is past oriented. RNT has been posited as a causal and maintaining factor for multiple disorders, including generalized anxiety disorder, depression, and insomnia. The current study aimed to further understand the contribution of RNT in insomnia symptoms, after controlling for anxiety and depression. A self-report battery measuring anxiety, depression, RNT and insomnia was administered to 101 college students. In this sample, 52% of participants endorsed clinical levels of insomnia. Bivariate correlations found …

The Associations Between Adolescent Motives For Social Media Use With Body Dysmorphia, Eating Disorder, And Anxiety And Depression Symptoms, Kaylan Melvin

Honors Theses

Adolescents spend a large amount of time on social media sites. This is notable, as adolescence is a crucial time for body image development. Additionally, recent findings suggest that using image-oriented social media sites, such as Facebook and Instagram, is associated with more body dissatisfaction and disordered eating. Among previous studies, certain social media motivations have been found to have an association with poor body satisfaction and well-being in adolescents. To our knowledge, no studies have directly examined the association between social media motivations and eating disorder, body dysmorphic disorder, and anxiety and depression symptoms in adolescents. The current study …

A Study Of First-Generation College Students At The University Of Mississippi, Brady Suttles

Honors Theses

First-generation college students (FGCS) are a distinct sub-population within higher education. In comparison to their peers, FGCS report increased levels of anxiety, depression, and stress along with lower levels of social support and academic attainment. Considering the unique context and history of the University of Mississippi (UM), it is crucial to understand the specific needs of FGCS enrolled at UM. The aims of this study were to: 1) assess the associations between FGCS status and mental health and academic achievement, and 2) determine whether sense of belonging moderates these associations.

First-generation college students had higher mean levels of depression symptoms …

Effects Of A Virtual Voice-Based Coach Delivering Problem-Solving Treatment On Emotional Distress And Brain Function: A Pilot Rct In Depression And Anxiety, Thomas Kannampallil, Et Al.

2020-Current year OA Pubs

Consumer-based voice assistants have the ability to deliver evidence-based treatment, but their therapeutic potential is largely unknown. In a pilot trial of a virtual voice-based coach, Lumen, delivering problem-solving treatment, adults with mild-to-moderate depression and/or anxiety were randomized to the Lumen intervention (n = 42) or waitlist control (n = 21). The main outcomes included changes in neural measures of emotional reactivity and cognitive control, and Hospital Anxiety and Depression Scale [HADS] symptom scores over 16 weeks. Participants were 37.8 years (SD = 12.4), 68% women, 25% Black, 24% Latino, and 11% Asian. Activation of the right dlPFC (neural region …

The Influence Of Nutrition On The Gut Microbiota And Psychiatric Disorders: A Review, Megha Bhagavan, Francis Jenney

Research Day

The symbiotic harboring of gut microorganisms within the gastrointestinal tract has a profound influence on host physiology, well-being, and disease pathology. More specifically, the gut bacteria are able to interact with dietary components from foods chosen by the host and consequently relay their beneficial or precarious effects locally and systemically. The gut bacteria have the capacity to maintain a healthy gut microbiome or perpetuate intestinal imbalance, known as gut dysbiosis. Gut dysbiosis has both local effects in gastrointestinal pathologies, such as intestinal bowel syndrome (IBS) and intestinal bowel disorder (IBD), as well as systemic pathologies, such as type II diabetes, …

Examining The Relationship Between Misophonia And Depression, Mary Bishop

Honors Theses

Because research on misophonia is in its early stages, few studies have examined correlations with other disorders. Misophonia has been shown to co-occur with a variety of anxiety-related and mood disorders. Understanding the link between depression and misophonia is important because both disorders contribute to significant impairment in daily work, social, and role functioning. This study aims to examine the relation between misophonia and depression in a community sample, which would expand knowledge demonstrated by previous studies using clinical and college samples. We hypothesized that misophonia and depression would have a positive correlation and that women would experience higher levels …

Links Between Mental Health And Employment Outcomes Among Adults With Autism Spectrum Disorder, Emma Atkinson

Honors Theses

Problem: Mental health outcomes related to Autism Spectrum Disorder (ASD) have been extensively researched, although most research in the area is on children with ASD. Studies on adults with ASD are scarcer. More specifically, studies that analyze the association between mental health and work-life balance (WLB) as well as mental health and job satisfaction (JS) among employed adults with ASD is limited. The purpose of this study was to analyze the association between mental health and WLB among adults with ASD, the association between mental health and perceived JS among adults with ASD, and whether or not ASD severity moderates …

College Student Depression Throughout Covid-19: Fall 2019-Spring 2022, Matthew Powless, Zachary Pilot, Valentin Bouvier, Elisabeth Brown, Mikaila Ealum, Lakota Iron Rope

Midwest Social Sciences Journal

The current study examined the trends in depression and emotion regulation for students (n = 899) at one university in the Midwest United States from prior to the COVID-19 pandemic (Fall 2019) through the Spring 2022 semester. An analysis of covariance (ANCOVA) was conducted, controlling for difficulties in emotion regulation and gender identity. The ANCOVA indicated that depression was significantly lower in Fall 2019 than in the remaining five semesters under investigation. Results of these analyses appear to indicate that depression rose significantly in students after the onset of the pandemic and implementation of social restrictions. This negative effect …

Rapid Neuroplasticity Changes And Response To Intravenous Ketamine: A Randomized Controlled Trial In Treatment-Resistant Depression, Jared Kopelman, Timothy A Keller, Benjamin Panny, Angela Griffo, Michelle Degutis, Crystal Spotts, Nicolas Cruz, Elizabeth Bell, Kevin Do-Nguyen, Meredith L Wallace, Sanjay J Mathew, Robert H Howland, Rebecca B Price

Staff and Researcher Publications

Intravenous ketamine is posited to rapidly reverse depression by rapidly enhancing neuroplasticity. In human patients, we quantified gray matter microstructural changes on a rapid (24-h) timescale within key regions where neuroplasticity enhancements post-ketamine have been implicated in animal models. In this study, 98 unipolar depressed adults who failed at least one antidepressant medication were randomized 2:1 to a single infusion of intravenous ketamine (0.5 mg/kg) or vehicle (saline) and completed diffusion tensor imaging (DTI) assessments at pre-infusion baseline and 24-h post-infusion. DTI mean diffusivity (DTI-MD), a putative marker of microstructural neuroplasticity in gray matter, was calculated for 7 regions of …

Cbt Technology Implementation With Pediatric And Adolescent Populations, Tracey W. Kreipe, Heath Gage, Sandra Obiebi

Doctor of Nursing Practice Projects

Abstract

Digital therapy is a growing healthcare intervention improving limited access to specialty care for specific populations and geographic areas. Cognitive Behavioral Therapy (CBT) applications focus on treating anxiety and depression and assist pediatric and adolescent patients in learning behavioral techniques as they wait for 3-6 months or longer to see a mental health provider. Such delays are attributed to the national shortage of mental health practitioners and the further scarcity of fewer psychiatric providers in rural areas, causing the potential for adverse patient outcomes. The setting for this 8-week quality improvement project was a pediatric care clinic that sees …

Improving Depression Remission Screening Compliance, Crystal Wingerter

Doctor of Nursing Practice Projects

Depressive disorders are widespread in the United States and are diagnosed and treated in the primary care setting. In 2019, there were an estimated 19.4 million adults that had at least one major depressive episode. The purpose of this project was to improve follow up and depression remission assessment for patients with a diagnosis of depression at a metropolitan family care practice clinic. The Patient Health Questionnaire (PHQ–9) was utilized for remission assessment. Front desk staff and providers were trained and granted access to the quality information system (QIS) in the electronic medical records (EMR) system which allowed easy identification …