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Effects Of Hyperglycemia In Cognition And Sex, Erin E. Mcdonald

Senior Honors Theses

An empirical study tested the effects of Type 1 Diabetes (T1D) on cognitive function in a hyperglycemic mouse model. Strong correlations between mental illnesses, such as major depressive disorder, neuropathologies like Alzheimer’s disease, and diabetes suggest comorbid pathology. Considering the prevalence of both T1D and cognitive decline within the general population, the findings were relevant and aimed to identify early signs of cognitive decline in diabetic patients. Behavioral tests and immunohistochemical staining were utilized to determine the cognitive function of the mice, revealing decline or deterioration caused by hyperglycemia. Data gathered from the hyperglycemic or control mice were analyzed based …

Impact Of Antidiabetic Medication Type On A New Episode Of Depression: A Retrospective Cohort Study In Texas, Usa, Lin-Na Chou, Mukaila A Raji, Holly M Holmes, Yong-Fang Kuo

Faculty, Staff and Student Publications

Objectives: To examine the associations between antidiabetic medication type and a new episode of depression using 100% Texas Medicare database during 2009 and 2018.

Design: A retrospective cohort study.

Setting: A population-based study using the Texas Medicare data.

Interventions: 11 common antihyperglycaemic medication types, alone and in combinations: metformin-only, five non-metformin-containing regimens (dipeptidyl peptidase-4 inhibitor (DPP4i) only, sulfonylureas (SU) only, thiazolidinediones (TZD) only, SU/DPP4i and SU/TZD) and five metformin-containing combination treatments (metformin/DPP4i, metformin/SU, metformin/TZD, metformin/SU/DPP4i and metformin/SU/TZD).

Participants: This study included 59 057 type 2 diabetes (T2D) patients from a cohort of Texas Medicare beneficiaries who were aged ≥66 years, …

Enhancing Provider Knowledge With Phq-9 Education, Laurette Abunaw

Walden Dissertations and Doctoral Studies

Depression represents a significant public health concern that often remains undiagnosed or untreated, primarily due to insufficient systematic screening in primary care settings. The lack of standardized screening tools such as the Patient Health Questionnaire-9 (PHQ-9) elevates patient risks, increasing symptom severity, increasing suicide rates, and delaying interventions. Research studies show that a significant number of individuals with depression go untreated for long durations, with primary care settings recognizing only a small percentage of cases. The PHQ-9 is an effective tool for assessing and monitoring depression in a primary care setting, leading to early detection of symptom severity. Clinical practice …

Multiple Platform Social Media Engagement Correlation With Perceived Depression, Anxiety, And Stress Among Active Church Members, Penny K. Hampton

Doctoral Dissertations and Projects

Social media has remained an area that each person has related to in their everyday experiences. The growth of social media has continued and expanded to include a wide range of varying platform opportunities for users. Given the variances with social media engagements, everyone differs with their resulting overall mental health characteristics. This study explored the relationship between the user engagement on multiple social media platforms and self-reported depression, stress, and anxiety. The variables included the number of social media platforms and the self-reported responses to the Depression, Anxiety, Stress Scale-21 (DASS21). For this study, the participants included 117 individuals …

Understanding The Impact Of Romantic Relationship Satisfaction On Depression In Women Veterans, Rhonda Jean Gaston

Doctoral Dissertations and Projects

Depression is a prevalent and impactful mental health issue worldwide, with a particularly high incidence among women. Previous research has established a positive association between romantic relationship satisfaction and depression in women. However, little attention has been given to the mental health of women veterans, a growing population within the United States military, leading to significant gaps in understanding their unique experiences. This nonexperimental retrospective study was conducted to examine how initial romantic relationship satisfaction predicted the reduction of depression symptoms following psychotherapy. Additionally, it explored how minority status among women veterans influenced post-treatment depression outcomes. Using archival data, between …

Pharmacogenomics-Guided Treatment Of Depression Evidence-Based Practice Scholarly Project, Richard A. Sonnier

Doctoral Dissertations and Projects

Pharmacogenomics is a popular topic in psychiatry today that is poised to replace the outdated trial-and-error paradigm of prescribing psychotropic medications. For patients suffering from a myriad of psychiatric disorders, it has been a frustrating period for those who have struggled with multiple failed trials of medications before finding relief from debilitating depression, anxiety, and many other mood-dysregulating disorders. Often, patients are forced to endure several weeks or months of trying psychotropic agents with poor responses and intolerable side effects before finally finding a medication that yields a desired outcome. In some cases, no therapeutic response is ever achieved. With …

Resilience And Extrication Stories From Female Victims Of Narcissistic Abuse And Intimate Partner Violence During The Covid-19 Pandemic Isolation Period, Kristin A. Musacchio

Doctoral Dissertations and Projects

I studied the prevalence of narcissistic abuse and intimate partner violence during the COVID-19 pandemic’s isolation period. This research provides a nuanced understanding of the tactics and consequences of narcissistic abuse and intimate partner violence during a global health crisis. I uncovered ways in which the COVID-19 pandemic has affected preexisting abusive behaviors while simultaneously providing new opportunities, during the isolation period, for the abusers to control and manipulate their partners. I explored resiliency and religious coping strategies to understand the psychological healing process of female victims of intimate partner violence or narcissistic abuse. A qualitative approach was utilized to …

An Uncharacteristic Case Presentation Of Functional Vision Disorder, Ramandeep Kaur Od, Theresa Zerilli-Zavgorodni Od, Nancy Shenouda-Awad Od

Optometric Clinical Practice

Background: Functional Vision Disorder (FVD), also commonly referred to as functional vision loss (FVL) or non-organic vision loss (NOVL), is defined as a visual acuity (VA) loss and/or visual field (VF) loss, without any identifiable ocular or cortical pathology. Many clinicians look at FVD as a diagnosis of exclusion and while it is imperative to rule out organic pathology, FVD diagnosis must be supported by clinical findings that prove normal visual function. Incorporating supplementary tests specific for demonstrating the integrity of the visual system and the non-organic nature of the symptoms will allow clinicians to be more confident when diagnosing …

Emotional Intelligence As A Moderator Between Depression, Loneliness, And Affect Intensity, Ryan Fleig

Theses and Graduate Projects

Emotional intelligence (EI) is a construct that has been present in psychology in various, non-specific forms for many years. Mayer and Salovey (1997) first created a specific construct of EI that centered on four key skills: emotion-perception; using emotions to facilitate thought; understanding one’s own and other’s emotions; and emotion regulation. Research on EI has largely been regulated to social domains, but some literature has established links between overall EI and specific EI skills and clinical symptoms such as depression and anxiety. The current study sought to further the literature on EI in clinical domains by studying correlations between emotion …

Mental Wellness Of The Saintly, Spiritual, And Secular: Who Has The Edge?, Addison Clevenger, Justin Dyer, Sam Hardy

FHSS Mentored Research Conference

This study examines the relationship between religious/spiritual identity and depression and anxiety levels at comparative baseline levels, and then longitudinally. Gathered from The Family Foundations of Youth Development Project, this study samples parent-child dyads from highly religious parts of the Western United States to determine how the mental health of these individuals is affected by the conjunction of spirituality and religiosity, the lack of either, or one divorced from the other. Results revealed that at baseline levels, participants across all groups who identified as “Spiritual but not Religious” had the highest levels of anxiety and depression, and children who identified …

The Association Of Sleep Quality And Depression On Having Three Vs. All Five Diagnostic Criteria Of Metabolic Syndrome, Nina Pollard

Walden Dissertations and Doctoral Studies

Metabolic syndrome is increasing in prevalence in the United States. To be diagnosed, three of the five diagnostic criteria must be met. There is a higher risk of metabolic syndrome due to lifestyle and social factors, with increased criteria occurring as an individual has unmet social determinants of health. This quantitative quasi-experimental/quasi-comparative study examined the association between education level, with sleep quality and depression as moderators, on a diagnosis of metabolic syndrome with all five criteria versus three criteria using a binary logistic regression while controlling for age, race, gender, income, employment, and marital status. Bronfenbrenner’s social ecological theory served …

An Exploration Of The Relationship Between Age And Disposition In The Juvenile Court Data, Jaden Reign Deblois

Honors Program Theses and Projects

Struggles with depression are prominent among the population of incarcerated individuals. After COVID-19, the impacts of depression became more profound among incarcerated youth. For youth with previous diagnoses, the impacts of depression were more severe. To better understand the scope of the issue, this literature review examines how the field currently understands COVID-19’s impact on the depression of incarcerated youth. Findings suggest that factors such as isolation, physiological social stressors, and prior mental health diagnosis contribute to depression among incarcerated youth. Implications for mental health prevention and treatment for incarcerated youth will be discussed.

Acculturation, Social Support, And Immigration-Related Stressors: Impact On Depression Among Single Mother Immigrants In The United States, Comfort Payne

Walden Dissertations and Doctoral Studies

Depression is a prevalent mental health condition that disproportionately affects immigrant single mothers in the United States, whose risk is heightened by unique vulnerabilities. The interplay between acculturation, social support, and economic burden in this population is underexplored. This quantitative, cross-sectional study examined the relationship between various factors and depression using 2020–2022 National Health Interview Survey data. Inclusion criteria were single immigrant mothers aged 19–60 years, who had lived in the U.S. for at least one year, had one or more dependent children, and self-reported depression status. The socioecological model provided a lens for identifying how individual, interpersonal, and structural …

A Long Non-Coding Erna Forms R-Loops To Shape Emotional Experience-Induced Behavioral Adaptations, Rose Marie Akiki

MUSC Theses and Dissertations

Emotional experiences often evoke neural plasticity that supports adaptive changes in behavior, including maladaptive plasticity associated with mood and substance use disorders. These adaptations are supported in part by experience-dependent activation of immediate-early response genes, such as Npas4. We discovered that a conserved, long non-coding enhancer RNA (lnc-eRNA) transcribed from an activity-sensitive enhancer produces DNA-RNA hybrid R-loop structures that support 3D chromatin-looping of the enhancer and proximal promoter and stimulus-induced, rapid Npas4 gene induction. We also show that this Npas4 lnceRNA and its R-loops are required for the development of behavioral adaptations produced by chronic psychosocial stress or cocaine exposure, …

Safety And Efficacy Of 112 Mg Intranasal Esketamine In Patients With Treatment-Resistant Depression: A Retrospective Observational Study From Outpatient Community Clinics, Kirsten Brinkmeier, Michael Kritzer, Brandon Doan, Cecilia Li, Nicholas Mischel

Medical Student Research Symposium

This retrospective study examined the safety and efficacy of 56, 84, and 112 mg intranasal (IN) esketamine via medical record review of 24 patients with treatment resistant depression (TRD). Doses ranged from 56 mg to 112 mg and were titrated across sessions to maximize individual response while considering tolerability. Treatment response was defined by reduction in average Patient Health Questionnaire-9 (PHQ-9) scores. Tolerability was defined by blood pressures at baseline, 40 minutes after, and 2 hours after drug administration. Patients ranged from 19 to 60 years old (average 38.87), and 15 (62.5%) were female. Patients received an average of 1 …

“They Love Our Rhythm, But Not Our Blues:” An Examination Of The Relationship Between Hip Hop On Depression, Anxiety, And Self-Care Among African American And Hispanic/Latinx Emerging Adults, Richard W. Wiley Jr.

LSU Doctoral Dissertations

Depression and anxiety are among the most common mental health problems for emerging adults of color in higher education. Specifically, African American/Black and Hispanic/Latinx emerging adults on college campuses have poorer mental health than their White counterparts. Considering the systemic oppression and cultural stressors that impact mental health among African American/Black and Hispanic/Latinx students, Critical Race Theory (CRT) and Emerging Adulthood Theory were theoretical frameworks for this study. The purpose of this study was to examine the relationship between Hip Hop music and depression, anxiety, and intentional use as self-care among African American/Black and Hispanic/Latinx emerging adults who were college …

Assessment Of Cognitive Domains In Major Depressive Disorders Using The Cambridge Neuropsychological Test Automated Battery (Cantab): Systematic Review And Meta-Analysis Of Cross-Sectional And Longitudinal Studies, Danilo Arnone, Reshma Ramaraj, Linda Östlundh, Teresa Arora, Syed Javaid, Romona Devi Govender, Emmanuel Stip, Allan H. Young

All Works

Cognitive difficulties are known to persist after remission of symptoms and to affect psychosocial functioning and quality of life. Cognitive function, measured with the Cambridge Neuro-psychological Test Automated Battery (CANTAB), is a reliable approach to measure cognitive function in major depression. This systematic review and meta-analysis appraise cross-sectional and longitudinal studies that used specific CANTAB tests to measure cognitive function in major depression and the effect of treatment (PROSPERO ID: CRD42022355903). 1212 studies were identified and 41 were included, 1793 patients and 1445 healthy controls. Deficits in executive functions were detected with the Stocking Of Cambridge (SOC) ‘number of problems …

Racial Discrimination, Social Support, And Perceived Qualification Differences: Analyzing The Impacts On Work-Related Stress And The Mental Health Of Black Women, Nyasha Chikwinya, Cayla Johnson

2025 Honors College Research Symposium

Through this study, this research looks at how racial discrimination at work that is perceived, has impacts on the mental health of Black women. We tend to focus on major issues such as stress, anxiety, and depression. The main ideas we will be exploring include: 1. Facing racial discrimination at work is stressful. Black women who deal with this can experience more psychological stress, 2. Having access to a support system or mentorship at work can help lessen the bad effects of work-related stress on Black women's health, and 3. When Black women see themselves as inferior to their white …

Racial Discrimination, Social Support, And Perceived Qualification Differences: Analyzing The Impacts On Work-Related Stress And The Mental Health Of Black Women, Cayla Johnson, Nyasha Chikwinya

2025 Honors College Research Symposium

Prior research indicates that racial discrimination greatly affects the mental well-being of Black women in their jobs (Berdahl and Moore, 2006). This matter is vital since the compounded impacts of racial discrimination can intensify job-related stress and lead to persistent mental health issues, such as anxiety and depression (Holder et al, 2015). We propose a study examining how racial discrimination at work is perceived and how it impacts mental health of Black women. Specifically, we hypothesize: H1. Black women who deal with racial discrimination can experience more psychological stress. H2. Having access to a support system or mentorship at work …

The Prevalence Of Depression And Its Clinical Characteristics Among Thalassemic Patients In Baghdad, Riziq Jasim, Mushtaq Hashim

Iraqi Postgraduate Medical Journal

Background: Thalassemia disorder is an inherited blood disorder causes the body to produce less hemoglobin, it’s classified to thalassemia major, thalassemia intermedia and thalassemia minor. Depression is a mood disorder that causes persistent feeling of sadness or emptiness and loss of interest that affects daily living.Aim of the study: to assess the prevalence of depression and its socio-demographic and clinical characteristics factors in sample of thalassemic patients. Methods: a cross-sectional study done with 140 thalassemic patients, from April 2022 to march 2023, the screening of depression done by Beck Depression Inventory scale, the diagnose of depression made according to DSM-5 …

Struggles In Adolescence: A Cross-Group And Multidimensional Analysis On High School Student Depression And Risk Behaviors, Jessica K. Sun, Ayanda Chakawa, Daniel X. Zhang

Manuscripts, Articles, Book Chapters and Other Papers

This study examines the multifaceted relationships between depression and risk behaviours among high school students. It utilizes nearly 1.5 million samples to explore nine broad categories – driving unsafety, weapon-related behaviours, physical fights, suicidality, smoking, alcohol consumption, substance abuse, unhealthy eating, and physical inactivity – encompassing 50 individual components. Employing normalized association tests, logistic regressions, and bootstrapping methods, the analysis evaluates the strength and significance of the depression-risk behaviour association across demographic groups. This study also maps out the multidimensional pattern among intersectional subgroups, offering novel insights into how depression impacts diverse student populations. The results highlight the heterogeneity of …

A Phenomenological Study Of School Staff Perceptions Of The Threat And Prevention Of School Violence, Rebecca Linton

Dissertations

My study addressed the issue of school safety and student mental health in schools in the United States. The purpose of this study was to identify the concerns staff members had about the system and procedures used to track students’ mental health and how staff and students are kept safe within the school environment. The overarching research question for my study was: What are the perceptions of school staff regarding school safety and the support students with mental health issues receive? I used a quantitative research method for my study, collecting data through surveys of teachers and administrators. The survey …

Effects Of Acute Stress On Executive Functions In Depression, Generalised Anxiety And Borderline Personality Disorder, T. M. Scott, Joanne M. Dickson

Research outputs 2022 to 2026

Background: Acute stress adaptively alters executive functions (EFs) essential for emotion regulation. Emerging systems of psychiatric classification, such as the Hierarchical Taxonomy of Psychopathology (HiTOP) and the Research Domain Criteria, emphasise the underlying mechanisms and dimensional nature of psychopathology. Distress disorders—a subfactor within the HiTOP model including major depressive disorder, generalised anxiety disorder and borderline personality disorder—are characterised by altered stress reactivity, impaired emotion regulation, and modest responsiveness to first-line psychotherapies. This systematic review sought to examine whether distress disorders and their related symptoms confer heightened vulnerability to transient EF impairment under conditions of acute stress. Methods: A comprehensive search …

Pandemic-Related Stress Increases Ptsd And Depression Risk In Traumatic Injury Patients: A Comparative Study Of Pre- And Peri-Pandemic Trauma Cases, Juan Pablo Zapata, Carissa W. Tomas, Sydney Timmer-Murillo, Terri A. Deroon-Cassini, Christine Larson, Lucas Torres, Amber Brandolino, Timothy J. Geier, Hason Khan, Andrew T. Schramm

Psychology Faculty Research and Publications

The COVID-19 pandemic significantly impacted the psychological well-being of the general population. However, there are limited studies that examine its mental health effects on patients who have experienced traumatic injuries and tracked their recovery over time. This study aimed to: (1) compare the rates and severity of post-traumatic stress disorder (PTSD) and depression between patients who sustained traumatic injuries before the COVID-19 pandemic (pre-pandemic) and those injured during the pandemic (peri-pandemic); and (2) assess whether the degree of pandemic-related stress (e.g., worry about infection, social isolation, loss of home/job) predicted the severity of PTSD or depression symptoms. Participants (N …

Interpretative Phenomenological Analysis Of Wellbeing Of An International Student With Depression And Suicidality From A Coping Perspective, Rumiko Nakano

Journal of Comparative & International Higher Education

No abstract provided.

Positive Illusions And Their Mental Health Implications, Caleb L. Ashley

SACAD: Scholarly Activities

Positive illusions, defined as overly optimistic self-evaluations, exaggerated perceptions of control, and unrealistically favorable outlooks on the future have been the subject of a breadth of research due to their implications in mental health and resilience. Empirical evidence suggests that, in moderate amounts, positive illusions can help support resilience and persistence and are correlated with overall well-being. However, their benefits may become detrimental if they are absent or excessively pronounced. By synthesizing existing research, this presentation seeks to provide a nuanced understanding of positive illusions and to offer insights into how their existence may inform treatment in clinical settings.

Assessing Nerve Block And Opioid Analgesics On Anxiety And Depression In Patients With Lumbar Radiculopathy, Ashley Deng, Liying Wei, Eduardo Espiridion

Tower Health Research Day

No abstract provided.

Prevalence Of Psychiatric And Sleep Disorders And Their Impact On Quality Of Life In Children With Hypermobile Ehlers-Danlos Syndrome: An Observational Study., Amanda K. Hertel, Jordan T. Jones, Ashley Lytch, Emily Cramer, Ariana Schroeder, William R. Black

Manuscripts, Articles, Book Chapters and Other Papers

Hypermobile Ehlers-Danlos Syndrome (hEDS) is the most common connective tissue disorder. However, few studies exist on psychiatric and sleep disorders in pediatric patients with hEDS. This study aims to describe psychiatric and sleep disorders and evaluate their impact on health-related quality of life (HRQoL) in pediatric patients with hEDS. As part of a longitudinal study, a convenience sample of 123 pediatric patients with hEDS, were recruited at a hEDS multidisciplinary clinic in sequential order over a seven-month period. Patient-reported outcomes were completed (Patient Reported Outcomes Measurement Information System Pediatric Profile Version 2 [PROMIS], Generalized Anxiety Disorder-7 [GAD-7], Adolescent Sleep Wake …

Efficacy And Safety Of Behavioural Activation On Depression In People With Co-Occurring Non-Communicable Diseases: Systematic Review And Meta-Analysis, Engida Yisma, Kuda Muyambi, Sandra Walsh, Shwikar Othman, Richard Gray, Kuan Liung Tan, Mary Steen, Martin Jones

Research outputs 2022 to 2026

Background People with non-communicable diseases (NCDs) have a higher prevalence of comorbid depression than the general population. While previous research has shown that behavioural activation is effective for general depression, its efficacy and safety in treating depression associated with NCDs remains unclear. Aims To compare the efficacy and safety of behavioural activation against comparators in reducing depression symptoms in people with NCDs. Method We searched six databases from inception until 30 March 2023 (updated 23 September 2024) for randomised controlled trials (RCTs) comparing behavioural activation with comparators for depression in people with NCDs. Risk of bias was assessed using the …

The Moderating Role Of Loneliness In The Relation Between Perceived Pressure To Be Thin, Perfectionism, And Internalizing Problems Among Latina Girls, Melissa Lopez

College of Science and Health Theses and Dissertations

Latina girls are at a high risk of depressive symptoms and self-injurious thoughts and behaviors. This study builds on the Perfectionism Social Disconnection Model to identify factors that may influence the development of these internalizing problems (Hewitt et al., 2006). Perceived pressure to be thin, perfectionistic self-presentation, and loneliness have all been linked to internalizing problems, including depressive symptoms in youth. This study focuses on Latina girls, specifically, and the ways that these variables combine to affect their well-being. This study highlights the relation between pressure to be thin and both depressive symptoms and self-injurious thoughts and behaviors and explores …