Open Access. Powered by Scholars. Published by Universities.®

Digital Commons Network™

Open Access. Powered by Scholars. Published by Universities.®

Depression

Discipline
Institution
Publication Year
Publication
Publication Type
File Type

Articles 2761 - 2790 of 4413

Full-Text Articles in Entire DC Network

Psychosocial Functioning And The Cortisol Awakening Response: Meta-Analysis, P-Curve Analysis, And Evaluation Of The Evidential Value In Existing Studies, Ian Andres Boggero, Camelia E. Hostinar, Eric A. Haak, Michael L. M. Murphy, Suzanne C. Segerstrom Oct 2017

Psychosocial Functioning And The Cortisol Awakening Response: Meta-Analysis, P-Curve Analysis, And Evaluation Of The Evidential Value In Existing Studies, Ian Andres Boggero, Camelia E. Hostinar, Eric A. Haak, Michael L. M. Murphy, Suzanne C. Segerstrom

Psychology Faculty Publications

Cortisol levels rise immediately after awakening and peak approximately 30-45 minutes thereafter. Psychosocial functioning influences this cortisol awakening response (CAR), but there is considerable heterogeneity in the literature. The current study used p-curve and metaanalysis on 709 findings from 212 studies to test the evidential value and estimate effect sizes of four sets of findings: those associating worse psychosocial functioning with higher or lower cortisol increase relative to the waking period (CARi) and to the output of the waking period (AUCw). All four sets of findings demonstrated evidential value. Psychosocial predictors explained 1%-3.6% of variance in CARi and AUCw …


Effects Of A Collaborative Care For Depression Intervention On Health Service Utilization And Depression Severity, Girlyn Arganza Cachaper Oct 2017

Effects Of A Collaborative Care For Depression Intervention On Health Service Utilization And Depression Severity, Girlyn Arganza Cachaper

Health Services Research Dissertations

Depression is the leading cause of disability worldwide, disproportionately affecting the Medicaid population. Collaborative care programs for depression are transforming primary care to increase access and coordinate physical and behavioral health services. Understanding the relationships between components of collaborative care programs, characteristics of participants, and their effect on outcomes can maximize program effectiveness. A pilot collaborative care for depression program within a Medicaid managed care organization was evaluated using administrative claims and case management data. Participants (n=444) included adults with prior Medicaid coverage and a comparison group identified using one-to-one propensity score-matching. Multivariate logistic regression models estimated the odds of …


Affective Factors Explaining The Association Between Depressive Functioning And Alcohol Outcomes, Peter D. Preonas Oct 2017

Affective Factors Explaining The Association Between Depressive Functioning And Alcohol Outcomes, Peter D. Preonas

Psychology Theses & Dissertations

Depressive symptoms and alcohol use frequently coexist. In college students, the rates of depression and alcohol use are higher than in the general population, making this population at particular risk for co-occurrence of depressive symptoms and drinking. Though research has shown that depressive symptoms precede alcohol use and problems in non-clinical populations, it is unclear what mechanisms contribute to this relationship. Further exploration into how this relationship occurs could inform and improve intervention of depression and alcohol abuse on college campuses. This study sought to (1) assess three potential mediators (i.e., need for affect, distress tolerance, emotion regulation) to the …


Physiological Correlates Of Affective Decision-Making In Anxiety And Depression, Louisa I. Thompson Sep 2017

Physiological Correlates Of Affective Decision-Making In Anxiety And Depression, Louisa I. Thompson

Dissertations, Theses, and Capstone Projects

Improving our understanding of cognitive and physiological profiles in anxiety and depression has the potential to reveal novel ways to target and improve treatments for these prevalent mental health conditions. The present study examined the impact of self-reported anxiety and depression symptoms on three established decision-making measures, the Iowa Gambling Task (IGT; Bechara, Damasio, Damasio, & Anderson, 1994), Balloon Analogue Risk Task (BART; Lejuez et al., 2002), and Game of Dice Task (GDT; Brand et al., 2005), in a diverse sample of 100 college students (age 18 to 35). Physiological measures of tonic heart rate variability and galvanic skin response …


The Role Of Therapeutic Engagement, Oral Language Proficiency, And Core Learning Indicators On The Effects Of Therapy For Youth With Depression, Amanda E. Wagstaff Aug 2017

The Role Of Therapeutic Engagement, Oral Language Proficiency, And Core Learning Indicators On The Effects Of Therapy For Youth With Depression, Amanda E. Wagstaff

College of Science and Health Theses and Dissertations

Youth with depression, particularly ethnic minority youth, have low rates of engagement in mental health services, indicating a large need to better understand the role of engagement in effective treatments for depression (Merikangas et al., 2011). Cognitive behavioral therapy (CBT) is one of the leading psychotherapeutic treatments available for youth with depression (Weisz, McCarty, & Valeri, 2006), but several questions still remain regarding why and in what circumstances this therapy is most appropriate. CBT posits that part of the positive treatment effects is accounted by learning certain cognitive and behavioral skills during and outside of session (i.e., through active homework …


An Examination Of Depression And Social Support Among African American Women In Substance Use Recovery, Jocelyn Rose Droege Aug 2017

An Examination Of Depression And Social Support Among African American Women In Substance Use Recovery, Jocelyn Rose Droege

College of Science and Health Theses and Dissertations

Depression is responsible for widespread functional impairment and disability in 16 million individuals across the United States, as well as societal costs that exceed $36 billion. There are numerous risk factors for depression, such as female gender, ethnic minority status, poverty, incarceration, and comorbid substance use disorders. Thus, low-income, criminal-justice-involved African American women in recovery from substance use problems represent a population that is particularly vulnerable to depression. Social support has been established as a protective factor against depression; however, the relationship between social support and depression has been understudied in such high-risk African American populations. The present study examined …


Recommendations For Developing Video Games To Address Depression Among College Students, John Bodycombe Aug 2017

Recommendations For Developing Video Games To Address Depression Among College Students, John Bodycombe

Graduate School of Professional Psychology: Doctoral Papers and Masters Projects

Depression is a significant problem on college campuses, and the data shows that prevalence is on the rise (The National Survey on Drug Use and Health [NSDUH], 2014; Stewart, Ricci, Chee, Hahn, & Morgenstein, 2003). Depression impacts the well-being of students and puts them at risk for a variety of issues (Leach, 2009; Adams, Wharton, Quilter, & Hirsch, 2008; Serras, Saules, Cranford, & Eisenberg, 2010; Cranford, Eisenberg, & Serras, 2009; Weitzman, 2004). Many students with depression do not receive care (Blanco, Okuda, Wright, Hasin, Grant, Liu, & Olfson, 20008; Eisenburg and Chung, 2012), or receive care that is not minimally …


Care Of Veterans: A Patient With Post Traumatic Stress Disorder And Depression In A Peri-Operative Scenario, Stacey Knight, Kelli M. White, Cynthia Stinson, Mary Ford, Lisa Donnelly, Gloria Morris Green Aug 2017

Care Of Veterans: A Patient With Post Traumatic Stress Disorder And Depression In A Peri-Operative Scenario, Stacey Knight, Kelli M. White, Cynthia Stinson, Mary Ford, Lisa Donnelly, Gloria Morris Green

General Submissions: Presentations (Oral and Poster)

Care of veterans concepts in nursing curriculum is vital for students in all settings to understand the impact that military service has on health (Johnson et al., 2013). Significant physical health issues, behavioral problems, substance abuse, and harmful effects on families have been associated with and exacerbated by multiple deployments (Seal et al., 2009). Although these behaviors are not typical for most service members after deployment, some are clearly at risk for a variety of psychological, behavioral, and neurological health issues resulting from their experiences during direct combat situations (Bush et al., 2011). With only 25% of all veterans taking …


Rwu First Amendment Blog: Jared A. Goldstein's Blog: Ri's Conversion Therapy Ban Protects Lgbtq Youth And It's Constitutional 08-09-2017, Jared A. Goldstein Aug 2017

Rwu First Amendment Blog: Jared A. Goldstein's Blog: Ri's Conversion Therapy Ban Protects Lgbtq Youth And It's Constitutional 08-09-2017, Jared A. Goldstein

Law School Blogs

No abstract provided.


A Meta-Analysis Of The Effect Of Therapist Experience On Outcome For Clients With Internalizing Disorders, Lucia M. Walsh Aug 2017

A Meta-Analysis Of The Effect Of Therapist Experience On Outcome For Clients With Internalizing Disorders, Lucia M. Walsh

Open Access Theses

Despite having the most prevalent group of psychiatric disorders, many people with internalizing disorders do not receive treatment. One factor related to lack of treatment is a shortage of qualified mental health therapists. Task shifting may be one solution to this shortage, but has been relatively unused due to the idea that less experienced therapists may not be able to attain commiserate client outcomes as more experienced therapists. However, a relationship between therapist experience and client internalizing outcomes has never been found, a critical first step in determining if task shifting is a viable option to getting millions of people …


Substance Use Disorders, Violence, Mental Health, And Hiv: Differentiating A Syndemic Factor By Gender And Sexuality, Kiyomi Tsuyuki, Eileen V. Pitpitan, Maria A. Levi-Minzi, Lianne A. Urada, Steven P. Kurtz, Jamila K. Stockman, Hilary L. Surratt Aug 2017

Substance Use Disorders, Violence, Mental Health, And Hiv: Differentiating A Syndemic Factor By Gender And Sexuality, Kiyomi Tsuyuki, Eileen V. Pitpitan, Maria A. Levi-Minzi, Lianne A. Urada, Steven P. Kurtz, Jamila K. Stockman, Hilary L. Surratt

Center for Health Services Research Faculty Publications

This paper measures syndemic substance use disorder, violence, and mental health and compares the syndemic among HIV-infected heterosexual men, heterosexual women, and men who have sex with men (MSM). Data were from a sample of high needs substance-using, HIV-infected people in South Florida between 2010 and 2012 (n = 481). We used confirmatory factor analysis to measure a syndemic latent variable and applied measurement invariance models to identify group differences in the data structure of syndemic co-morbidities among heterosexual men, heterosexual women, and MSM. We found that variables used to measure the syndemic fit each sub-group, supporting that substance use …


Using A Culturally Adapted Learning Tool With Latinos Diagnosed With Depression, Monica Lechuga Aug 2017

Using A Culturally Adapted Learning Tool With Latinos Diagnosed With Depression, Monica Lechuga

Social Work Theses - Archive

Due to stigma, low mental health knowledge, and cultural beliefs a significant number of Latinos do not seek treatment for depression. Interventions and treatment methods that are culturally adapted and consider the patient's cultural perspective are minimal due to the lack of bilingual mental health providers. Using secondary data, this study reviewed a quantitative research study conducted at a community health center. The study conducted by Dr. Sanchez at a community health clinic, utilized a culturally adapted fotonovela as a depression education intervention (DEI) for Latinos diagnosed with depression. The purpose of this review was to analyze the effectiveness of …


Predictive Relationship Of Positive Lifestyle Choices With Emotional Distress Of Undergraduate College Students: An Analysis Of American College Health Association Data, Robin Lockhart Aug 2017

Predictive Relationship Of Positive Lifestyle Choices With Emotional Distress Of Undergraduate College Students: An Analysis Of American College Health Association Data, Robin Lockhart

Nursing Dissertations - Archive

Undergraduate student reports of anxiety and depression have risen each year since 2012 to the most recent report of 17% experiencing anxiety and 14% experiencing depression (ACHA, 2016). The significance of the experience of anxiety and depression in this population is that they are the top-reported factors affecting academic attrition (ACHA, 2016). The purpose of this study was to examine the predictive relationship of three healthy lifestyle behaviors and emotional distress among undergraduate college students. The three healthy lifestyle choices examined were nutrition, exercise and rest. The prevalence of emotional distress and depression within each year of study also was …


Self-Forgiveness In Japanese Adolescents., Tetsuo "Ted" Sato Aug 2017

Self-Forgiveness In Japanese Adolescents., Tetsuo "Ted" Sato

Electronic Theses and Dissertations

The literature of forgiveness has been proliferated the last two decades (Davis et al., 2015b), but it has primarily focused on forgiveness of others and the research of self-forgiveness has just increased in recent years (Worthington & Langberg, 2012). Woodyatt and Wenzel (2013a) proposed a process-oriented approach of self-forgiveness while considering three possible responses to the self (i.e., genuine self-forgiveness, pseudo self-forgiveness, and self-punitiveness) after interpersonally offending others. Self-forgiveness among children and adolescents and in Japanese culture was discussed. The association of self-forgiveness to depressive and anxiety symptoms, and culturally and developmentally unique factors (i.e., fear of negative evaluation and …


Go For A Walk! Monitoring Walking For Depressed Mood, Michael E. Shrake Aug 2017

Go For A Walk! Monitoring Walking For Depressed Mood, Michael E. Shrake

All NMU Master's Theses

Literature suggests that exercise has benefits for health and mood. For people suffering from depression however, even summoning motivation to go for a walk can seem impossible, no matter the alleged benefits. My study builds on current articles suggesting that wearable technology like activity-tracking bracelets can have significant effects on motivation and physical health goals. The current study followed 11 individuals who met the minimum threshold for depression as measured by the Patient Health Questionnaire-9 (PHQ-9) for a period of 28 days and tracked their walking using a Jawbone UP activity bracelet. The results showed that daily activity differed significantly …


Friendship Dissolution In Adolescence: Considering The Factors Surrounding Dissolution And Their Associations With Adjustment, Kaitlin M. Flannery Jul 2017

Friendship Dissolution In Adolescence: Considering The Factors Surrounding Dissolution And Their Associations With Adjustment, Kaitlin M. Flannery

Doctoral Dissertations

Friendships are important relationships in the lives of adolescents. However, about half of adolescent best friendships end across the course of a school year, and very little research has focused on the factors surrounding their dissolution. The current study aimed to examine different aspects of friendship dissolution in adolescence, such as the number of friendship dissolutions experienced, the reasons driving dissolution, and the way that friendships ended in a sample of middle school students (N = 354). Results suggest that dissolutions are incredibly common, reported by 86% of the sample, that conflict/betrayal is the most common reason for friendship …


Neurophysiological Characteristics Of Magnetic Seizure Therapy Vs. Electroconvulsive Therapy In Geriatric Patients With Severe Depression, Monica T. Ly Jul 2017

Neurophysiological Characteristics Of Magnetic Seizure Therapy Vs. Electroconvulsive Therapy In Geriatric Patients With Severe Depression, Monica T. Ly

Master's Theses

Objective: Magnetic seizure therapy (MST) is under development as an alternative to electroconvulsive therapy (ECT), as it offers reduction in depression symptoms with fewer adverse cognitive effects. This study examined the feasibility and efficacy of MST versus ECT in a randomized trial of geriatric patients with severe depression, then compared the neurophysiological characteristics of seizures induced by MST or ECT and investigated potential links between seizure expression and therapeutic response.

Method: Six patients (mean age: 64.8) with severe depression were randomized to receive MST (n=3) or ECT (n=3) until maximal antidepressant effect (mean number of sessions: 14.67). Depression symptoms were …


Depression And Its Predictors In Hemodialysis Patients In Taiwan, Chou-Ping Chiou Jul 2017

Depression And Its Predictors In Hemodialysis Patients In Taiwan, Chou-Ping Chiou

International Nursing Research Congress (INRC)

Background. Depression is a common psychological problem in hemodialysis patients that affects their treatment compliance and lifestyle as well as their quality of life. Previous studies showed that depression and anxiety symptom in older HD patients were significantly higher than that of the age-matched controls. Social support is important for HD patients" treatment as it influences dialysis patients" health.

Aim. The objectives of this study were to investigate depression in hemodialysis patients in Taiwan and the important predictors for depression.

Methods. This study used a correlational cross-sectional design. Data for 150 hemodialysis patients were collected from one hemodialysis center in …


Health Literacy, Depression, Anxiety, And Posttraumatic Stress Disorder As Predictors Of Biological Markers Of Immune Functioning In Youth And Young Adults With Hiv, Courtney A. Lynn Jul 2017

Health Literacy, Depression, Anxiety, And Posttraumatic Stress Disorder As Predictors Of Biological Markers Of Immune Functioning In Youth And Young Adults With Hiv, Courtney A. Lynn

USF Tampa Graduate Theses and Dissertations

Human immunodeficiency virus (HIV) is a virus that affects the body’s immune system (Centers for Disease Control [CDC], 2016a). HIV is a worldwide epidemic and disproportionately impacts youth in the United States. Youth living with HIV (YLWH) face significant mental health problems, namely depression, anxiety, and posttraumatic stress disorder (PTSD) with rates of these disorders discrepant from those in the general population. In addition to psychological difficulties, health literacy is another factor that influences individuals with HIV and is a priority of research with adolescents (Kalichman et al., 2000; Manganello, 2008). The National HIV/AIDS Strategy: Update 2020 (White House Office …


Early Trauma Exposure And Marijuana Use As Well As Dependence From Adolescence To Emerging Adulthood, Ian Andru Marsee Jul 2017

Early Trauma Exposure And Marijuana Use As Well As Dependence From Adolescence To Emerging Adulthood, Ian Andru Marsee

Theses and Dissertations

This study examines the impact of two types of trauma exposure, mistreatment by an adult as a child and exposure to stressful life events as an adolescent, and their impact on marijuana use as an adolescent and emerging adult and marijuana dependence as an adult. This study also investigates the mediating role of depressive symptoms on the relationship between trauma exposure and marijuana use and dependence. The AddHealth dataset, a nationally representative and longitudinal dataset, was used to assess these relationships. Results show that both types of trauma predict marijuana use and dependence. Results also show that there are indirect …


For The Love Of A Game: The Effects Of Pathological Video Game Use On Romantic Relationship Satisfaction, Hailey Elizabeth Holmgren Jul 2017

For The Love Of A Game: The Effects Of Pathological Video Game Use On Romantic Relationship Satisfaction, Hailey Elizabeth Holmgren

Theses and Dissertations

Media use may have the potential to influence romantic relationships, depending on the context of media use. For example, pathological media use, which includes symptoms of addiction such as relapse, withdrawal, and conflict with family and friends over media use, may be particularly damaging to romantic relationships. Additionally, research shows that pathological video game use can negatively influence factors of mental health, including depression. The current study includes 183 heterosexual couples from the Eastern United States. Both members of each couple completed online surveys answering questions regarding pathological media use, depression, and relationship satisfaction. Results showed that male pathological video …


Effectiveness Of Aerobic Exercises On Depression: An Experimental Study On Old Age At Mangalore, Sooraj K Mr, Vinish V Mr Jul 2017

Effectiveness Of Aerobic Exercises On Depression: An Experimental Study On Old Age At Mangalore, Sooraj K Mr, Vinish V Mr

Manipal Journal of Nursing and Health Sciences

Introduction: Old age homes have taken up the traditional role of family for the security of elderly people. Studies have proved that prevalence rate of depression were high among institutionalized elderly. Objective: The aim of this study is to determine the depression status among the inmates, evaluate the effectiveness of aerobic exercises on depression among elderly and to find association between depression score among elderly with selected demographic variables. Methodology: Quantitative evaluative approach with quasi-experimental one group pre-test post-test design was used. Convenience-sampling technique was used to select 50 people above the age of 60 years, residing at a selected …


Insula And Amygdala Resting-State Functional Connectivity Differentiate Bipolar From Unipolar Depression, E Ambrosi, D B Arciniegas, A Madan, K N Curtis, M A Patriquin, R E Jorge, G Spalletta, J C Fowler, B C Frueh, R Salas Jul 2017

Insula And Amygdala Resting-State Functional Connectivity Differentiate Bipolar From Unipolar Depression, E Ambrosi, D B Arciniegas, A Madan, K N Curtis, M A Patriquin, R E Jorge, G Spalletta, J C Fowler, B C Frueh, R Salas

Staff and Researcher Publications

Objective: Distinguishing depressive episodes due to bipolar disorder (BD) or major depressive disorder (MDD) solely on clinical grounds is challenging. We aimed at comparing resting-state functional connectivity (rsFC) of regions subserving emotional regulation in similarly depressed BD and MDD.

Method: We enrolled 76 in-patients (BD, n = 36; MDD, n = 40) and 40 healthy controls (HC). A seed-based approach was used to identify regions showing different rsFC with the insula and the amygdala. Insular and amygdalar parcellations were then performed along with diagnostic accuracy of the main findings.

Results: Lower rsFC between the left insula and the left mid-dorsolateral …


Evaluation Of Psychology Clinicians’ Attitudes Towards Computerized Cognitive Behavior Therapy, For Use In Their Future Clinical Practice, With Regard To Treating Those Suffering From Anxiety And Depression, Nivek Dunne Jul 2017

Evaluation Of Psychology Clinicians’ Attitudes Towards Computerized Cognitive Behavior Therapy, For Use In Their Future Clinical Practice, With Regard To Treating Those Suffering From Anxiety And Depression, Nivek Dunne

Antioch University Dissertations & Theses

Computerized Cognitive Behavioural Therapy (CCBT) is an empirically supported therapeutic modality used in the treatment of anxiety and depression. It is an important area of research considering there is much research lacking in this area, especially regarding trainee and qualified psychology clinicians' attitudes which are informative in terms of uptake and adherence. This study examined trainee and qualified psychology clinicians' attitudes towards CCBT for use in their future clinical practice, with regard treating those suffering from anxiety and depression. Overall, 31 participants took part in the research, which resulted in 31 completed informed consent forms and questionnaires being returned to …


Evaluating An Adjunctive Mobile App To Enhance Psychological Flexibility In Acceptance And Commitment Therapy, Michael E. Levin, Jack Haegar, Benjamin G. Pierce, Rick A. Cruz Jul 2017

Evaluating An Adjunctive Mobile App To Enhance Psychological Flexibility In Acceptance And Commitment Therapy, Michael E. Levin, Jack Haegar, Benjamin G. Pierce, Rick A. Cruz

Psychology Faculty Publications

The primary aims of this study were to evaluate the feasibility and potential efficacy of a novel adjunctive mobile app designed to enhance the acquisition, strengthening, and generalization of acceptance and commitment therapy (ACT) skills being taught in therapy. A sample of 14 depressed/anxious clients receiving ACT used the ACT Daily app for two weeks in a pre-post, open trial design. Participants reported a high degree of program satisfaction. Clients significantly improved over the two-week period on depression and anxiety symptoms as well as a range of psychological inflexibility measures. Analyses of mobile app data indicated effects of …


Making Lifestyle Choices To Reduce Late-Life Depression Risk, Maria C. Norton, Elizabeth B. Fauth, Jessica Weyerman Jul 2017

Making Lifestyle Choices To Reduce Late-Life Depression Risk, Maria C. Norton, Elizabeth B. Fauth, Jessica Weyerman

All Current Publications

Depression is a complex condition involving insufficient levels of brain chemicals, life stressors, thought processes, behaviors, and coping mechanisms. Medications and counseling therapy are effective in treating depression, and research suggests that several lifestyle practices also help to protect us from depression, and speed up our recovery if we do experience it. These behaviors, such as being socially connected, eating healthy and exercising, cost little to nothing but can have profound benefits on our overall quality of life and help us to stay depression-free.


Affective And Cognitive Effects Of Awe In Predicting Hopelessness And Brooding Rumination, Eldita Tarani Jun 2017

Affective And Cognitive Effects Of Awe In Predicting Hopelessness And Brooding Rumination, Eldita Tarani

Master's Theses

This study investigated the effects of awe, as a positive emotion, in ameliorating

depressive symptoms such as hopelessness and rumination. Previous research indicates that awe is unique compared to other positive emotions in that is elicited by information rich-stimuli that facilitate shifts in cognition as one attempts to accommodate this new information to their current frame of reference. In addition, awe was found incite a self- diminishing effect that contrast the inflated significance one places on the self, during negative self-referential thinking (e.g. hopelessness). We hypothesized that exposure to an awe stimuli (video) would prompt subjects to feel less hopeless …


Depression And Inflammatory Changes After Cognitive-Behavioral Stress Management As Predictors Of Survival And Disease Recurrence In Women With Non-Metastatic Breast Cancer, Laura C. Bouchard Jun 2017

Depression And Inflammatory Changes After Cognitive-Behavioral Stress Management As Predictors Of Survival And Disease Recurrence In Women With Non-Metastatic Breast Cancer, Laura C. Bouchard

Open Access Dissertations

Both depression and inflammation are independently associated with breast cancer health outcomes, and multiple studies have shown that depression and inflammatory markers may be linked among women with breast cancer. Studies of cognitive-behavioral based psychosocial interventions have found beneficial intervention effects on time to survival and recurrence in breast cancer patients. However, the mechanisms through which interventions affect clinical health outcomes are less understood. It has been suggested that psychosocial interventions may affect long-term breast cancer clinical disease endpoints via effects on immune and inflammatory processes, but more research is necessary to explore these relationships. The current study examined the …


A Randomized Controlled Pilot Trial Of The Unified Protocol For The Treatment Of Emotional Disorders In Children (Up-C), Sarah Michelle Kennedy Jun 2017

A Randomized Controlled Pilot Trial Of The Unified Protocol For The Treatment Of Emotional Disorders In Children (Up-C), Sarah Michelle Kennedy

Open Access Dissertations

Although cognitive-behavioral therapy (CBT) is a well established treatment for anxiety and depressive disorders in children (Chorpita et al., 2011), a significant proportion of children do not respond to existing CBT protocols, and many protocols do not adequately address high rates of comorbidity among emotional disorders. Transdiagnostic approaches may help to improve treatment response in children, particularly for clinical or sub-clinical comorbid conditions not adequately targeted by disorder-specific CBT, and to prevent the later development of commonly occurring comorbid conditions. The Unified Protocol for the Treatment of Emotional Disorders in Children (UP-C; Ehrenreich-May et al., in press) is a transdiagnostic …


Genome-Wide Association Study Of Borderline Personality Disorder Reveals Genetic Overlap With Bipolar Disorder, Major Depression And Schizophrenia, S. H. Witt, F. Streit, M. Jungkunz, J. Frank, Ney Alliey Rodriguez Jun 2017

Genome-Wide Association Study Of Borderline Personality Disorder Reveals Genetic Overlap With Bipolar Disorder, Major Depression And Schizophrenia, S. H. Witt, F. Streit, M. Jungkunz, J. Frank, Ney Alliey Rodriguez

School of Medicine Publications

Borderline personality disorder (BOR) is determined by environmental and genetic factors, and characterized by affective instability and impulsivity, diagnostic symptoms also observed in manic phases of bipolar disorder (BIP). Up to 20% of BIP patients show comorbidity with BOR. This report describes the first case-control genome-wide association study (GWAS) of BOR, performed in one of the largest BOR patient samples worldwide. The focus of our analysis was (i) to detect genes and gene sets involved in BOR and (ii) to investigate the genetic overlap with BIP. As there is considerable genetic overlap between BIP, major depression (MDD) and schizophrenia (SCZ) …