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Pathways To Better Sleep, Mairead E. Moloney, Emily Slade, Joon Chung, Kory Heier, Daniela C. Moga Dec 2025

Pathways To Better Sleep, Mairead E. Moloney, Emily Slade, Joon Chung, Kory Heier, Daniela C. Moga

Sociology Faculty Publications

Background: Rural Appalachia has some the highest rates of sleep and health disparities in the United States. This study investigates the relationship between social support and insomnia severity in rural Appalachian adults, with specific attention to the potential mediating roles of depression, anxiety, and stress. Methods: Participants from 12 rural Eastern Kentucky counties completed validated measures of insomnia severity, social support, depression, anxiety, and perceived stress. Using R, we calculated descriptive statistics and fit mediation models for depressive symptoms, anxiety symptoms, and stress, with social support as the exposure and insomnia severity as the outcome. Results: Aligning with regional demographics, …


Transdiagnostic Links Of Reward Processing In Obsessive-Compulsive Disorder And Depression, Kevin M Wagner, Matti Cervin, Jessica S C Cheng, Jasmine Arriaga, Vanessa Zavala Cruz, Dayan Berrones, Josselyn S Muñoz, Renee M Frederick, Jacey L Anderberg, Belinda E Núñez Bracho, Victor R Adorno, Leonardo F Fontenelle, Andrew D Wiese, Latin American Trans-Ancestry Initiative For Ocd Genomics (Latino), Brazilian Obsessive-Compulsive Spectrum Disorder Working Group (Gttoc), James J Crowley, Eric A Storch Dec 2025

Transdiagnostic Links Of Reward Processing In Obsessive-Compulsive Disorder And Depression, Kevin M Wagner, Matti Cervin, Jessica S C Cheng, Jasmine Arriaga, Vanessa Zavala Cruz, Dayan Berrones, Josselyn S Muñoz, Renee M Frederick, Jacey L Anderberg, Belinda E Núñez Bracho, Victor R Adorno, Leonardo F Fontenelle, Andrew D Wiese, Latin American Trans-Ancestry Initiative For Ocd Genomics (Latino), Brazilian Obsessive-Compulsive Spectrum Disorder Working Group (Gttoc), James J Crowley, Eric A Storch

Faculty, Staff and Students Publications

Objectives: Transdiagnostic models aim to uncover shared mechanisms across mental disorders. Reward responsiveness (the ability to experience pleasure from rewarding stimuli) is a plausible, yet underexplored, transdiagnostic mechanism linking obsessive-compulsive disorder (OCD) and depression. This study used network analysis to (1) examine how key reward responsiveness domains are interlinked in individuals with OCD and (2) explore how each domain is uniquely associated with OCD and depression.

Methods: A total of 1345 individuals with a history of OCD symptoms (ages 18-88, 71 % women) from Latino communities in the United States (including Puerto Rico) and nine Latin American countries completed validated …


Basic Effectiveness Of Group Mindfulness-Based Cognitive Therapy (Gmbct) In The University Setting, John Robert C. Rilveria, Nisseth Clarize S. Carido, April Veronica G. Lansangan, Alaya Gabrielle N. Villaflor, Anna Cristina A. Tuazon, Divine Love A. Salvador, Violeta V. Bautista Dec 2025

Basic Effectiveness Of Group Mindfulness-Based Cognitive Therapy (Gmbct) In The University Setting, John Robert C. Rilveria, Nisseth Clarize S. Carido, April Veronica G. Lansangan, Alaya Gabrielle N. Villaflor, Anna Cristina A. Tuazon, Divine Love A. Salvador, Violeta V. Bautista

Asia-Pacific Social Science Review

The COVID-19 pandemic has reshaped daily life and amplified mental health challenges worldwide, with university students identified as a particularly vulnerable group. To address this need, the present study evaluated the effectiveness of group mindfulness-based cognitive therapy (GMBCT) as an evidence-based intervention for students receiving psychosocial services during the pandemic. Using a pretest–posttest design, data from 34 students randomly assigned to either GMBCT or individual treatment-as-usual (TAU) provided by a university-based clinic were analyzed. To evaluate treatment effects, an analysis of covariance (ANCOVA) was conducted to compare post-treatment outcomes between the two groups while controlling for pre-treatment scores, treatment length, …


Oral Ketamine For Treatment Resistant Depression: A Literature Review, Maeve Buni, Alanna Eisenbeiser Dec 2025

Oral Ketamine For Treatment Resistant Depression: A Literature Review, Maeve Buni, Alanna Eisenbeiser

Physician Assistant Capstones, 2020-current

Objective: Assess the efficacy and safety of oral ketamine as alternative therapy for those with treatment resistant depression (TRD). Design: Literature review. Methods: On November 14, 2024, a search was done in Pubmed and James Madison University’s EBSCO Psychology and Behavioral Sciences Collection for the terms “ketamine” and “treatment resistant depression,” excluding parenteral routes of administration and including only randomized controlled trials in adults published in 2018-2024. Results: Three randomized controlled trials that utilized evidence-based surveys to assess antidepressant effects were analyzed. Conclusion: The antidepressant effects of oral ketamine found in these RCTs were somewhat mixed. Oral ketamine did appear …


Is Hormonal Contraceptive Use Associated With An Increased Incidence Of Depression?, Natalie Montesano, Virginia H. Billings Dec 2025

Is Hormonal Contraceptive Use Associated With An Increased Incidence Of Depression?, Natalie Montesano, Virginia H. Billings

Physician Assistant Capstones, 2020-current

Objective: To investigate the proposed positive association between hormonal contraception (HC) use and depression incidence. Design: Literature review. Method: A search across CINAHL Plus with Full Text and PsycInfo databases was conducted to find three prospective cohort studies with a focus on HC use and depression which were evaluated individually and collectively. Results: Three studies were found that met search criteria: de Wit et al., Johansson T et al., Skovlund et al. Conclusion: All studies found a positive association between depression in adolescent HC users while only two of the three (Skovlund et al., Johansson T et al.) found this …


Psychiatric Comorbidities And Treatment Modalities In Children With Osteogenesis Imperfecta: A Systematic Review Of Mental Health, Julia M Morales, Camille F Villar, Beatriz Varman, Gianna M Colombo, Danqi Li, Sarah J Sadek, Marie-Eve Robinson, Chaya N Murali, Kara Ayers, Jocelyn Gomez, Brendan Lee, V Reid Sutton, Eric A Storch, Andrew D Wiese Dec 2025

Psychiatric Comorbidities And Treatment Modalities In Children With Osteogenesis Imperfecta: A Systematic Review Of Mental Health, Julia M Morales, Camille F Villar, Beatriz Varman, Gianna M Colombo, Danqi Li, Sarah J Sadek, Marie-Eve Robinson, Chaya N Murali, Kara Ayers, Jocelyn Gomez, Brendan Lee, V Reid Sutton, Eric A Storch, Andrew D Wiese

Library Staff Publications

To evaluate the prevalence of psychiatric signs and symptoms and describe psychotherapeutic and psychopharmacological interventions among children with osteogenesis imperfecta (OI). PRISMA guidelines were followed, and the study was registered in PROSPERO (CRD42024588284). Studies (n = 1419) were identified across five databases. Eligible studies, identified by independent reviewers, included peer-reviewed research on psychiatric comorbidities or interventions in children with OI. Data extraction included study design, population characteristics, mental health outcomes, and treatment effectiveness, with all studies assessed for quality and bias. Findings were synthesized to evaluate the prevalence of psychiatric comorbidities and intervention effectiveness. Five articles met inclusion criteria after …


The Association Between Loneliness And Mental Health In Underserved Communities, Ameemah Khan, Yu-Ping Chang Dec 2025

The Association Between Loneliness And Mental Health In Underserved Communities, Ameemah Khan, Yu-Ping Chang

Biennial Convention (CONV)

Background: Loneliness is a distressing emotional state that arises when an individual's actual social relationships do not align with their desired social connections. As loneliness becomes increasingly prevalent among adults, its adverse effects on mental health have grown more evident. Research links loneliness to poor sleep quality, suicidal ideation, severe depressive symptoms, and heightened stress. These effects are particularly pronounced in underserved communities, where social determinants of health disproportionately impact African Americans, contributing to poorer health outcomes. However, limited research explores the relationship between loneliness, sleep, and depression specifically within African American populations.

Purpose: This study aims to determine whether …


Psychological Variables That Best Predict Health Related Behaviors In College Students, Arianna Gamaggio Dec 2025

Psychological Variables That Best Predict Health Related Behaviors In College Students, Arianna Gamaggio

Honors Theses

The present study examined which psychological factors best predicted health behaviors in college students. The psychological factors that were addressed included anxiety, depression, grit, and psychological flexibility. The health behaviors were examined by using a composite variable that included sleep, diet, and exercise. A total of 265 students participated in the study, but only 174 (μ age = 21) met the criteria for inclusion. Participants completed validated self-report measures such as the GAD- 7 (anxiety), PHQ-9 (depression), Short Grit Scale, Psy-Flex-6 (psychological flexibility), as well as health behavior assessments that measured eating behaviors, sleeping, and exercise habits. Correlational analyses indicated …


Cognitive Behavioral Therapy: The Relationship Between Diet, Anxiety, And Depression And The Moderating Effect Of Cbt, Deborah J. Wright Dec 2025

Cognitive Behavioral Therapy: The Relationship Between Diet, Anxiety, And Depression And The Moderating Effect Of Cbt, Deborah J. Wright

Doctoral Dissertations and Projects

This study examined how cognitive behavioral therapy (CBT) techniques including cognitive restructuring and positive affirmations affect the relationship between dietary patterns and depression and anxiety symptoms. Research has established that CBT and diet affect depression and anxiety independently, but less research examines their collective impact. The study included 154 adult participants who filled out the Patient Health Questionnaire-9 and the Generalized Anxiety Disorder-7 alongside a Dietary Habits Checklist and a CBT Engagement Checklist during the previous two weeks. The results from multiple linear regressions showed no statistically significant moderation effects of CBT engagement on the relationship between diet and depression …


Treatment Concerning Grief Disorder After Covid-19: Can Spiritual Care Help?, Tamika Marie Johnson Dec 2025

Treatment Concerning Grief Disorder After Covid-19: Can Spiritual Care Help?, Tamika Marie Johnson

Doctoral Dissertations and Projects

The phenomenological study described the experiences of spiritual care for adults who lost a loved one due to COVID-19 in Texas. The theory guiding the study was Viktor Frankl’s logotherapy, which was humanity’s search for meaning in a finite world governed by spiritual principles (García-Alandete, 2024; Parker, 2022; Seligman & Reichenberg, 2014). Grief was one of the occurrences that grappled with humanity’s understanding of life. Death was a universal phenomenon, and grief occurred as a response to a loss (Fernández & González-González, 2022). Research shows that symptoms of grief dissipate over time. When it was accompanied by prolonged time or …


Elucidating Neurocognitive Mechanisms Underlying Depression-Related Differences In Executive Control Under Stress, Benjamin Swanson Dec 2025

Elucidating Neurocognitive Mechanisms Underlying Depression-Related Differences In Executive Control Under Stress, Benjamin Swanson

Graduate Theses and Dissertations

Executive control under stress has been shown to be a robust predictor of psychopathology, especially Major Depressive Disorder (i.e., depression). However, the underlying neural mechanisms that might explain this association have not been examined. To address this gap, both controls (n = 30) and individuals with current or past depression (n = 30) completed a modified Stroop task under fMRI. Behaviorally, we assessed both participants’ executive control performance and their subjective affect during the task. At the neural level, we examined brain regions related to both executive-related control (e.g., DLPFC) and executive-related affective processes (e.g., amygdala, striatum), as well as …


Social Support And Depression In Latinx Youth: A Meta-Analysis, Dulce Diaz Benitez Dec 2025

Social Support And Depression In Latinx Youth: A Meta-Analysis, Dulce Diaz Benitez

Graduate Theses and Dissertations

Although previous meta-analyses have found significant relationships between social support and youth outcomes, neither has included ethnicity as a moderator or even described the ethnic breakdown in the studies analyzed (Chu et al., 2010; Rueger et al., 2016). Studies that have looked at the relationship between social support and outcomes in Latinx youth have found mixed findings. This study examined the relationship between social support and depression in Latinx youth living in the United States. This study also explored differences in the strength of the relationship between social support and depression in several previously studied moderators (function of social support, …


Exercise As A Treatment For Depression And Anxiety Symptoms In College Students, Ashley J. Fountain Dec 2025

Exercise As A Treatment For Depression And Anxiety Symptoms In College Students, Ashley J. Fountain

ATU Honors Projects

Anxiety and depression have become increasingly prevalent among college students, with rates rising to levels that demand urgent and accessible treatment alternatives. Traditional interventions such as psychotherapy and pharmacological treatments, while effective for many, present limitations including high cost, side effects, and barriers to access. This paper examines exercise as a holistic, evidence-based treatment modality for reducing symptoms of depression and anxiety in college students. Recent research demonstrates that aerobic exercise, resistance training, and yoga each produce meaningful physiological and psychological benefits through mechanisms involving neurotransmitter regulation, reduced cortisol levels, and enhanced self-esteem. Studies comparing exercise with antidepressant medications show …


Temporal Associations Between Social Media Use Frequency And Social Media Addiction And Depressive, Anxiety, And Insomnia Symptoms Among Hispanic Emerging Adults: Moderation By Identity Exploration And Instability And Negativity, Miguel Andres Garcia Dec 2025

Temporal Associations Between Social Media Use Frequency And Social Media Addiction And Depressive, Anxiety, And Insomnia Symptoms Among Hispanic Emerging Adults: Moderation By Identity Exploration And Instability And Negativity, Miguel Andres Garcia

Open Access Theses & Dissertations

The number of social media users has drastically increased in recent years, and rates of social media use are particularly pronounced among emerging adults and Hispanic groups. Furthermore, emerging adults are at risk for poor mental health and report poor sleep health, and Hispanic groups may experience sleep disparities compared to their non-Hispanic White counterparts. Although many studies have assessed the associations between social media use frequency and social media addiction and depressive, anxiety, and insomnia symptoms, fewer have investigated these associations prospectively. Similarly, few studies have assessed potential moderators of these associations. Thus, the current study investigated the temporal …


Associations Between School Experiences And Mental Health Outcomes By Gender Identity In Sexual And Gender Minority Youth In Texas And California, 2022 - 2024, Andrea Susana Yanez Dec 2025

Associations Between School Experiences And Mental Health Outcomes By Gender Identity In Sexual And Gender Minority Youth In Texas And California, 2022 - 2024, Andrea Susana Yanez

Open Access Theses & Dissertations

Background: Depression and anxiety affect populations differently, with diagnoses disproportionately higher among sexual and gender minority groups, including LGBTQ+ youth. School experiences shape mental health; negative environments, bullying, and lack of support worsen outcomes, while affirming policies, peer support, and inclusive curricula are protective. Methods: This secondary analysis of the Family, Housing, and Me (FHAM) Project followed 83 LGBTQ+ youth from South Texas and California's Inland Empire (2022-2024). Data on sociodemographic characteristics, school experiences, and mental health outcomes were collected at baseline and at Waves I and II over 25 months. Analyses included descriptive statistics, monthly comparisons, and bivariate and …


Analyzing The Hidden Impact Of Work Stress On Mental Health, Shaikha Aljabry Dec 2025

Analyzing The Hidden Impact Of Work Stress On Mental Health, Shaikha Aljabry

Theses

Occupational stress and deteriorating mental health constitute an increasing issue in the global community, and the problem of how job demands, personal resources, and cognitive processes interrelate to determine employee well-being is hardly known. This dissertation will study these dynamics by incorporating theory-driven Structural Equation Modeling (SEM) with data-driven Machine Learning (ML) methods that offer explanatory and predictive information. The study examines the influences of job demands, personal resources, effort–reward imbalance (ERI), emotional labor, cognitive appraisal, and social support on the stress and mental health outcomes of a sample of 5,000 employees working in various industries and regions of the …


Quality Improvement Project: The Impact Of Staff Education On Utilization Of The Phq-9 Tool And Follow-Up Management Protocol, Shuntak Jerideau Nov 2025

Quality Improvement Project: The Impact Of Staff Education On Utilization Of The Phq-9 Tool And Follow-Up Management Protocol, Shuntak Jerideau

Doctor of Nursing Practice Projects

Depression is a prevalent mental health disorder that affects daily functioning. Timely screening enables the identification of symptoms, monitoring treatment efficacy, and informs additional treatment such as referrals. The practice site reported low screening rates of patient’s post-psychiatric hospitalization, which was attributed to inadequate knowledge of the PHQ-9 tool. The purpose of this quality improvement project was to evaluate the impact of staff education on the utilization of the PHQ-9 tool and follow-up management protocol in a mental health clinic. A quasi-experimental design method was used in an outpatient mental health clinic. Pretest knowledge of the PHQ-9 was obtained from …


Antidepressant Use In Older Age Bipolar Disorder (Oabd): Results From The Gage-Bd International Consortium, P. J. Chen, Lisa T. Eyler Nov 2025

Antidepressant Use In Older Age Bipolar Disorder (Oabd): Results From The Gage-Bd International Consortium, P. J. Chen, Lisa T. Eyler

Faculty Scholarship

Background Antidepressants are still commonly prescribed in bipolar disorders, despite ongoing controversy of the potential risk of inducing hypomania/mania. There is limited knowledge about the characteristics of antidepressant use in older age bipolar disorder (OABD; age ≥50) in the current literature. Aim To describe antidepressant use, sociodemographic and clinical correlates of a global sample of OABD individuals. Methods The Global Aging and Geriatric Experiments in Bipolar Disorder (GAGE-BD) consortium provided cross-sectional international data on OABD individuals ( n = 746) and younger-age bipolar disorder (YABD, age <50 years; n = 692) regarding antidepressant use. Multivariate logistic regression was employed to assess the association between AD use with demographic and clinical variables. Results Of 1252 participants, 33.1 % of OABD individuals and 38.1 % of YABD individuals were using antidepressants. In multivariable models among OABD, antidepressant use was associated with BD type II (OR = 1.61, 95 % CI: 1.09–2.38), higher depression severity (mild-to-moderate: OR = 1.86, 95 % CI: 1.13–3.06; severe: OR = 4.23, 95 % CI: 2.38–7.50), lower YMRS scores (OR = 0.93, 95 % CI: 0.89–0.97), female sex (OR = 1.37, 95 % CI: 1.00–1.89), lower education (OR = 0.61, 95 % CI: 0.43–0.86), and being unemployed (OR = 0.69, 95 % CI: 0.50–0.96). Antidepressant monotherapy was reported in 18 % of OABD users ( n = 46) and 19 % of YABD users ( n = 51). These findings suggest that both clinical severity and sociodemographic characteristics influence antidepressant prescribing in OABD. Conclusion Antidepressant use was less prevalent in OABD compared to YABD, and associated with female sex, lower education, lack of occupation, type II BD, higher depression severity and lower mania scores. In OABD, antidepressants appear to be used more commonly in contexts where they may be clinically more indicated, such as increased depression severity.


Exploring The Acceptability Of The Kimberley Mum’S Mood Scale For Perinatal Mental Health Screening In Gove District Hospital, North-East Arnhem Land, Tom P. Atkinson, Erica P. Spry, David Atkinson, Julia V. Marley, Emma Carlin Nov 2025

Exploring The Acceptability Of The Kimberley Mum’S Mood Scale For Perinatal Mental Health Screening In Gove District Hospital, North-East Arnhem Land, Tom P. Atkinson, Erica P. Spry, David Atkinson, Julia V. Marley, Emma Carlin

Journal of the Australian Indigenous HealthInfoNet

Objective: Across Australia perinatal mental health challenges disproportionately impact Aboriginal women. Identifying Aboriginal women at risk of adverse mental health outcomes in the perinatal period is an important step in supporting their overall health and wellness. Current screening tools have significant limitations when used with Aboriginal women.

The Kimberley Mums Mood Scale (KMMS) is a culturally secure approach to screening for perinatal mental health disorders in Aboriginal women. It has been validated in the Kimberley region of Western Australia and may be able to improve mental health screening in other regions. In this study the KMMS was trialled at a …


Incorporating Behavioral Health Strategies In Primary Care To Improve Outcomes Of Depressed Patients, Amy L. Brummett Nov 2025

Incorporating Behavioral Health Strategies In Primary Care To Improve Outcomes Of Depressed Patients, Amy L. Brummett

Student Scholarly Projects

Practice Problem: Depression, otherwise known as major depressive disorder, is a mood disorder characterized by persistent feelings of sadness, loss of interest, sleep disturbances, changes to weight (both gain and loss), difficulty concentrating, and in extreme cases, suicidal thoughts, and/or attempts (Mayo Clinic, 2022). An estimated 8.3% or 21.0 million adults in the United States have experienced at least one episode of depression. Primary care clinicians are often the first to recognize the symptoms of depression. Depression was very prevalent in the clinic where this DNP Scholarly project took place. The owner/nurse practitioner found that she was increasingly treating depressed …


Psychological Impact Of Pulmonary Embolism: A Narrative Review., Farooq Hyder, Hina Pervaiz, Fnu Karishma, Daya Kumari, Poonam Kumari, Ali Karim, Hari Vishal Nenwani, Allah Warayo, Kishor Kumari, Muhammad Salman, Abida Parveen, Mubeena Javid, Raveena Bai Bansari Nov 2025

Psychological Impact Of Pulmonary Embolism: A Narrative Review., Farooq Hyder, Hina Pervaiz, Fnu Karishma, Daya Kumari, Poonam Kumari, Ali Karim, Hari Vishal Nenwani, Allah Warayo, Kishor Kumari, Muhammad Salman, Abida Parveen, Mubeena Javid, Raveena Bai Bansari

Journal of Community Hospital Internal Medicine Perspectives

Background: Pulmonary embolism (PE) is a potentially life-threatening thromboembolic condition that demands urgent medical attention. While significant strides have been made in the diagnosis, treatment, and prevention of PE, its long-term psychological consequences remain underexplored. Survivors often face considerable emotional and psychological challenges that can impair recovery and reduce quality of life. This narrative review aims to explore the psychological impact of PE, including common mental health outcomes such as anxiety, depression, post-traumatic stress disorder (PTSD), and health-related fears. It also examines contributing factors such as persistent physical symptoms, anticoagulation therapy, social and occupational disruptions, and gaps in mental health …


A Case Study Exploring Lecanemab Antibody Infusion And Reminiscence Therapy For Early Alzheimer’S Disease, Martina Masry Nov 2025

A Case Study Exploring Lecanemab Antibody Infusion And Reminiscence Therapy For Early Alzheimer’S Disease, Martina Masry

Doctoral Dissertations and Projects

This case study examined whether a 12-month combined therapy (RT-L), which includes reminiscence therapy and lecanemab monoclonal antibody infusion therapy, will clear beta amyloid accumulation in the brain, slow cognitive decline, decrease depression, reduce anxiety, and increase the quality of life in a participant with mild cognitive impairment due to early Alzheimer’s dementia. The sample included one White female (age = 68) with mild cognitive impairment due to early Alzheimer’s disease who is currently being treated by a geriatrician at a facility in the Midwest. The outpatient treatment included a lecanemab antibody infusion of 10mg/kg every two weeks for 12 …


Implementing Pst In Older Adults Facing Major Surgery: A Randomised Controlled Pilot Study, Victoria Tang, Lejla Pepic, Erika Higuchi, Christina Keny, Elizabeth Macias Lopez, Ezenwa C Onyema, Harleen Sandhu, Veronica Yank, Patrick J Raue Nov 2025

Implementing Pst In Older Adults Facing Major Surgery: A Randomised Controlled Pilot Study, Victoria Tang, Lejla Pepic, Erika Higuchi, Christina Keny, Elizabeth Macias Lopez, Ezenwa C Onyema, Harleen Sandhu, Veronica Yank, Patrick J Raue

Faculty, Staff and Student Publications

Introduction: Depressive symptoms are common in the growing geriatric surgical population and are associated with important patient-centred surgical outcomes, including postoperative delirium, discharge to postacute care facility and decline in functional status. Few interventions have been developed to address depressive symptoms in the perioperative setting.

Methods and analysis: We designed a feasibility and acceptability study of a nine-session problem-solving therapy (PST) telehealth perioperative intervention aimed at reducing postoperative functional decline and depressive symptoms among at-risk older adults undergoing major surgical procedures. Acceptability will be evaluated using a patient-centred five-question survey, assessing participant satisfaction and perceived usefulness of the perioperative intervention. …


Metadata Analysis On The Relationship Between Sleep, Depression, And Cognition In Older Adults, Sara Miller, Kristie Stephens, Grayson Harris, Vincent Flegeance Nov 2025

Metadata Analysis On The Relationship Between Sleep, Depression, And Cognition In Older Adults, Sara Miller, Kristie Stephens, Grayson Harris, Vincent Flegeance

Science University Research Symposium (SURS)

Metadata Analysis on the relationship between sleep, depression, and cognition in older adults

Abstract

Previous research has revealed that both sleep and depression play significant roles in influencing memory. Adequate sleep facilitates memory consolidation during rest, ultimately enhancing cognitive performance. In contrast, elevated levels of depression are associated not only with physical symptoms, but also with declines in cognitive functioning. The present study aims to determine whether the cognitive benefits of sufficient sleep duration outweigh the detrimental effects of depression on memory. We hypothesize that sleep duration will have a stronger influence on memory consolidation in older adults than depression. …


Advancing Children's Mental Health In Nevada, Kelliann Beavers, Christopher Kearney Nov 2025

Advancing Children's Mental Health In Nevada, Kelliann Beavers, Christopher Kearney

Lincy Institute Events

Nevada ranks 51st nationally in youth mental health access and services, underscoring persistent shortages and disparities across the state. Nearly one in four youths aged 12–17 (23.5%) experienced a major depressive episode in the past year, and 73% did not receive treatment. Approximately 34,000 Nevada youths have reported suicidal thoughts—an urgent call for prevention and coordinated support.

During the 2024–2025 school year, 31.3% of Clark County School District students were chronically absent (missing 10% or more of school days), a challenge closely linked to mental health struggles and socioeconomic barriers.

This community forum provided an opportunity to generate dialogue and …


Risk Of Late-Onset Depression In Long-Term Survivors Of Breast, Prostate, And Colorectal Cancer, Melissa Taylor, Sarah Westvold, Jessica Long, Terry Hyslop, Andrea Silber, Rebecca Forman, Faiza Yasin, Tendai Kwaramba, Shi-Yi Wang, Michael Leapman, Michael Cecchini, Ira Leeds, Lisa Spees, Stephanie Wheeler, Cary Gross, Kevin Oeffinger, Michaela Dinan Nov 2025

Risk Of Late-Onset Depression In Long-Term Survivors Of Breast, Prostate, And Colorectal Cancer, Melissa Taylor, Sarah Westvold, Jessica Long, Terry Hyslop, Andrea Silber, Rebecca Forman, Faiza Yasin, Tendai Kwaramba, Shi-Yi Wang, Michael Leapman, Michael Cecchini, Ira Leeds, Lisa Spees, Stephanie Wheeler, Cary Gross, Kevin Oeffinger, Michaela Dinan

Kimmel Cancer Center Faculty Papers

IMPORTANCE: The prevalence of depression is higher in cancer survivors than in the general population. As the long-term cancer survivor population increases, it is increasingly important to understand risk factors for late-onset depression.

OBJECTIVE: To identify risk factors associated with late-onset depression in long-term (5-year) survivors of breast, prostate, or colorectal cancer.

DESIGN, SETTING, AND PARTICIPANTS: This retrospective cohort study used 2022 linkage of Surveillance, Epidemiology, and End Results (SEER) and Medicare data to identify 5-year survivors of breast, prostate, or colorectal cancer 66 years or older who were enrolled in fee-for-service Medicare and had no previous depression diagnosis. Long-term …


Opposing Roles Of Microglial And Macrophagic C3ar1 Signaling In Stress-Induced Synaptic And Behavioral Changes, Ashutosh Tripathi, Alona Bartosh, Dania Jose, Jocelyn Mata, Usama Hussein, Fernanda Laezza, Zhongming Zhao, Anilkumar Pillai Nov 2025

Opposing Roles Of Microglial And Macrophagic C3ar1 Signaling In Stress-Induced Synaptic And Behavioral Changes, Ashutosh Tripathi, Alona Bartosh, Dania Jose, Jocelyn Mata, Usama Hussein, Fernanda Laezza, Zhongming Zhao, Anilkumar Pillai

Faculty, Staff and Student Publications

The social deficits following chronic stress conditions are linked to synaptic dysfunction in the brain. Complement system plays a critical role in synapse regulation. Although complement has been implicated in chronic stress-induced behavior deficits the cellular substrates and mechanisms underlying complement-mediated behavior changes under chronic stress conditions are not known. In the present study, we investigated the role of complement component 3a receptor (C3ar1) in microglia and monocytes/macrophages (Mo/MΦ) in chronic unpredictable stress (CUS)-induced synapse loss and behavior deficits in mice. We found that deletion of microglial C3ar1 attenuated stress-induced social behavior deficits and changes in neuroinflammatory as well as …


Depression Polygenicity And Disease Activity And Disability Worsening In Multiple Sclerosis, Ali Manouchehrinia, Kathryn C Fitzgerald, Amber Salter, Ruth Ann Marrie, Lars Alfredsson, Charles N Bernstein, James M Bolton, Gary Cutter, John D Fisk, Lesley A Graff, Carol A Hitchon, Jan Hillert, Ingrid Kockum, Yi Lu, Fred D Lublin, Kyla Mckay, Tomas Olsson, Scott Patten, Amit Patki, Hayley Riel, Klementy Shchetynsky, Pernilla Stridh, Hemant K Tiwari, Jerry S Wolinsky, Kaarina Kowalec Nov 2025

Depression Polygenicity And Disease Activity And Disability Worsening In Multiple Sclerosis, Ali Manouchehrinia, Kathryn C Fitzgerald, Amber Salter, Ruth Ann Marrie, Lars Alfredsson, Charles N Bernstein, James M Bolton, Gary Cutter, John D Fisk, Lesley A Graff, Carol A Hitchon, Jan Hillert, Ingrid Kockum, Yi Lu, Fred D Lublin, Kyla Mckay, Tomas Olsson, Scott Patten, Amit Patki, Hayley Riel, Klementy Shchetynsky, Pernilla Stridh, Hemant K Tiwari, Jerry S Wolinsky, Kaarina Kowalec

Faculty, Staff and Student Publications

Objective: A better understanding of factors associated with multiple sclerosis (MS) disease activity and disability is needed. Given the strong link between comorbid depression and MS disease activity and disability, we aimed to determine whether the depression genetic burden, as modelled using its polygenic score, is associated with MS disease activity and disability worsening.

Methods: In this cohort study, we used samples from neurologist-defined adult people with MS (PwMS) followed in clinical care or during a clinical trial from existing cohorts: Canada, the United States (US), and Sweden with extensive longitudinal phenotypes. We computed the depression polygenic score (PGS) and …


The Interactive Effects Of Negative Life Events, Cortisol Reactivity, And Gender On Psychological Distress Among Emerging Adults, Li Shen Chong, Teresa Mejia, Kate L. Senich, Christy L. Olezeski, Elana B. Gordis Oct 2025

The Interactive Effects Of Negative Life Events, Cortisol Reactivity, And Gender On Psychological Distress Among Emerging Adults, Li Shen Chong, Teresa Mejia, Kate L. Senich, Christy L. Olezeski, Elana B. Gordis

Faculty Research, Scholarly, and Creative Activity

Negative life events are associated with the development of psychological distress, including depression, anxiety, and traumatic stress symptoms. Evidence suggests that individual differences in stress response system activity may alter susceptibility to psychological distress for those with exposure to negative life events. In particular, women experience greater levels of psychological distress than men. Given that emerging adulthood is characterized by stressful, significant life transitions that may constitute risks for psychological distress, this study examined whether hypothalamic-pituitary-adrenal (HPA) axis activity and gender influenced the link between negative life events and psychological distress among emerging adults. Participants ( N = 176; mean …


Post Spinal Cord Injury (Sci) Related Depression And Anxiety, Felecia Marshall Oct 2025

Post Spinal Cord Injury (Sci) Related Depression And Anxiety, Felecia Marshall

Lynchburg Journal of Medical Science

This article aims to examine the prevalence, significant factors, and clinical significance of depression and anxiety in individuals with spinal cord injury (SCI). Depression and anxiety are common after an SCI. These problems are difficult to recover from and, as such, can have a negative impact on a patient’s quality of life. This article stresses the need for early diagnosis and treatment with both cognitive behavioral therapy and pharmacological treatments for those with SCI. Mental health can be improved through this method. A comprehensive search of studies in PubMed was conducted. In 10 peer-reviewed articles, researchers uncovered findings concerning the …