Digital Commons Network^™

Examining Associations Between Social Needs And Mental Health Among Youth And Young Adults With Diabetes, Andrea Danielle Brown

Theses and Dissertations

Household food insecurity (HFI) disproportionally affects people with diabetes living in the United States and is more likely to occur in households with children and in minority race/ethnicity households. Food insecure people with youth-onset diabetes likely have increased risk for poor mental health due to dealing with stress and cost related to diabetes management, especially if facing additional health-related social needs that intersect with HFI. If left untreated, poor mental health among youth and young adults (YYA) with diabetes can lead to diabetes-related complications, increased health care costs, and mortality. Yet few studies have examined associations between HFI and mental …

Exploration Into The Relationship Between Colitis And Depression: A Potential Role For The Aryl Hydrocarbon Receptor, Kasie Lynn Roark

Theses and Dissertations

Inflammatory Bowel Disease (IBD) is a group of chronic gastrointestinal disorders with unclear etiology comprised of two defined disorders – Crohn’s Disease (CD) and Ulcerative Colitis (UC). IBD leads to chronic pain, socially isolating symptoms, and an overall reduction in patient quality of life. There is currently no cure for IBD. Due to decreased mucous production and weakening of the colonic epithelial lining, gut-microbiota and their metabolites can invade the intestinal lamina propria and circulate systemically, a term known as “leaky gut”. Recent studies show a relationship exists between peripheral inflammation, such as IBD, and depression. The gut-brain axis (GBA) …

Exercise And Mental Health Over The Course Of A Semester, Jamie Alexis Whitney

Theses and Dissertations

Introduction and purpose: Anxiety and depression are two of the most common mental health struggles in the United States each year. There has been promising research noting the positive effects of exercise on lowering symptoms of both anxiety and depression. Anxiety and depression are highly prevalent on college campuses, especially during high stress portions of the semester. The purpose of this study was to observe the changes in mental health over the course of the semester and if exercise level mediated any of these changes in the university population. Methods: Participants scanned a QR code or followed a link to …

Covid-19, Olfactory Functioning, And Depressive Symptoms, Kevin Davis Psy.D.

Dissertations

The focus in this study was to investigate whether people who continue to experience a disordered sense of smell after recovering from COVID-19 are more likely to have higher levels of depressive symptoms. Data collection involved two questionnaires: the Patient Health Questionnaire-9 (PHQ-9) to assess depressive symptoms and the Assessment of Self-Reported Olfactory Functioning and Olfaction-Related Quality of Life (ASOF) to assess olfactory functioning. Additionally, general survey questions were asked to evaluate physical and mental health outcomes related to COVID-19. Results showed individuals who did not subjectively return to their baseline sense of smell after recovering from COVID-19 had lower …

Prevalence And Trends Of Depression Among Cyberbullied Adolescents - Youth Risk Behavior Survey, United States, 2011 – 2019, Jason Nicholson, Catherine Marcum, George E. Higgins

International Journal of Cybersecurity Intelligence & Cybercrime

The difference in depression between non-cyberbullied and cyberbullied youth is not well understood. To describe the prevalence and trends in depression among cyberbullied adolescents. Using cross-sectional, nationally-representative data from the YRBS 2011 - 2019, we estimated the prevalence and trends of depression across the total years and within cyberbullied groups that include biological sex and race and ethnicity among adolescents. The results indicated the prevalence of depression was higher among those that were cyberbullied. Within the cyberbullied groups the total trend was higher than the non-cyberbullied, females had a higher prevalence of depression than males, and Hispanics had a higher …

Towards Scalable Mental Health: Leveraging Digital Tools In Combination With Computational Modeling To Aid In Treatment And Assessment Of Major Depressive Disorder, Matthew D. Nemesure

Dartmouth College Ph.D Dissertations

Major depressive disorder (MDD) is a debilitating disorder that impacts the lives of nearly 280 million individuals worldwide, representing 5% of the overall adult population. Unfortunately, these statistics have been both trending upward and are also likely an underestimate. This can be primarily attributed to lack of screening paired with a lack of providers. Worldwide, there are roughly 450 individuals living with MDD per mental health care provider. Adding to this burden, approximately half of affected individuals that do receive care of any kind will fail to remain in remission. The goal of this thesis work is to leverage statistical …

Liberating Self: An Autoethnographic Inquiry Into Black Male Mental Health, Phillip J. Roundtree Sr.

Social Work Doctoral Dissertations

This autoethnography offers a first-person perspective on Black male mental health experiences. It incorporates personal narratives and academic research to explore the intersectionality of race, gender, and mental health, as well as the impact of historical and contemporary systemic racism and discrimination on Black males' psychological and emotional well-being.

The Black Liberation Psychology theoretical framework and Africana Studies Conceptual framework examined how cultural norms, hip-hop culture, stigma, and societal factors, including racism, discrimination, and stereotypes about Black masculinity, shape Black male mental health experiences. The study also highlights Black males' development of coping mechanisms and resilience strategies to navigate these …

Psychosocial Predictors Of Early Postpartum Depressive And Anxious Symptoms In Primiparous Women And Their Partners., Erin J Henshaw, Marie Cooper, Teresa Wood, Stacey N Doan, Sanchita Krishna, Marie Lockhart

OhioHealth Research Institute Articles

BACKGROUND: While the majority of research on postpartum depressive and anxious symptoms has focused on mothers, a growing body of research suggests a need to understand the role of the partner's health and relationship quality as predictors of postpartum maternal depression, while also better understanding correlates of partner or paternal depression in the postpartum period. The purpose of the current study is to evaluate mother and partner stress, anxiety, mood, infant care support, and relationship quality as predictors of perinatal depressive and anxious symptoms in first time mothers and partners during the postpartum hospital stay.

METHODS: First time parent couples …

The Nrf2 Pathway In Depressive Disorders: A Systematic Review Of Animal And Human Studies, Gabriele Sani, Stella Margoni, Andrea Brugnami, Ottavia Marianna Ferrara, Evelina Bernardi, Alessio Simonetti, Laura Monti, Marianna Mazza, Delfina Janiri, Lorenzo Moccia, Georgios D Kotzalidis, Daniela Pia Rosaria Chieffo, Luigi Janiri

Faculty, Staff and Students Publications

There is increasing interest in the involvement of antioxidative systems in protecting from depression. Among these, Nrf2 occupies a central place. We aimed to review the role of Nrf2 in depression. For this reason, we conducted a PubMed search using as search strategy (psychiatr*[ti] OR schizo*[ti] OR psychot*[ti] OR psychos*[ti] OR depress*[ti] OR MDD[ti] OR BD[ti] OR bipolar[ti] OR Anxiety[ti] OR antidepress*[ti] OR panic[ti] OR obsess*[ti] OR compulsio*[ti] OR “mood disord*”[ti] OR phobi*[ti] OR agoraphob*[ti] OR anorex*[ti] OR anorect*[ti] OR bulimi*[ti] OR “eating disorder*”[ti] OR neurodevelopm*[ti] OR retardation[ti] OR autism[ti] OR autistic[ti] OR ASM[ti] OR adhd[ti] OR “attention-deficit”[ti]) AND nrf2, …

Autistic Masking, Joshua Evans, Thalia Markowski, Steven V. Rouse Dr., Elizabeth J. Krumrei-Mancuso Dr.

Seaver College Research And Scholarly Achievement Symposium

This study investigated the relationships between autistic masking and depression, anxiety, gender identity, sexual orientation, social trauma, self-esteem, authenticity, and autistic community involvement. Participants were autistic adults (n=342) recruited through autistic social media groups. The majority of participants (63%) reported being members of sexual minorities. The study found higher self-reported autistic masking behaviors were associated with higher reports of past social trauma (p < .001, b = .26), greater anxiety (p < .001, b = .37) and depression symptoms (p < .001, b = .312), lower self-esteem (p < .001, b = -.25), lower authentic living (p = .005, b = -.16), greater accepting of external influence (p < .001, b= .33), higher self-alienation (p < .001, b = .26), and lower participation within the autistic community (p < .001, b = -.19). Autistic masking was not found to be associated with gender identity or sexual orientation. Participants who reported involvement in previous ABA therapy reported higher past social trauma than participants involved in some other forms of therapy such as cognitive behavior therapy.

Antidepressant Augmentation Versus Switch In Treatment-Resistant Geriatric Depression, Eric J Lenze, Pilar Cristancho, Torie R Gettinger, Emily Lenard, J Philip Miller, Ginger E Nicol, Vy T Pham, Lei Yang, Et Al.

2020-Current year OA Pubs

BACKGROUND: The benefits and risks of augmenting or switching antidepressants in older adults with treatment-resistant depression have not been extensively studied.

METHODS: We conducted a two-step, open-label trial involving adults 60 years of age or older with treatment-resistant depression. In step 1, patients were randomly assigned in a 1:1:1 ratio to augmentation of existing antidepressant medication with aripiprazole, augmentation with bupropion, or a switch from existing antidepressant medication to bupropion. Patients who did not benefit from or were ineligible for step 1 were randomly assigned in step 2 in a 1:1 ratio to augmentation with lithium or a switch to …

The Relationship Among Depression, Motivational Factors, And Diabetes Management In Emerging Adults With Type 1 Diabetes, Sahar Elmenini, April Idalski Carcone, Deborah Ellis

Medical Student Research Symposium

Self-determination theory (SDT) posits intrinsic motivation arises from fulfilling three psychological needs – autonomy, self-efficacy, and relatedness. SDT is useful for understanding the challenges emerging adults (EA, age 18-30) living with a chronic illness, like type 1 diabetes (T1D), face including developing independence, autonomy and new relationships while parental support and involvement decrease. This places EAs at risk for sub-optimal health. Depression can further decrease motivation. The aim of this study is to test the hypothesis that depressive symptoms are associated with motivation (autonomy and self-efficacy) which are associated with diabetes management (DM) in EAs with T1D. Participants (N=52) were …

Replacing Adjunctive Medications For Treatment-Resistant Depression Using Repetitive Transcranial Magnetic Stimulation: Case Report, Anita Vaishampayan Bs, Bassem Saad Md, Daniel Amarasinghe Bs, Carly Brin Lmsw, Richard Balon Md, Nicholas Mischel Mdphd

Medical Student Research Symposium

Repetitive transcranial magnetic stimulation (rTMS) is an effective treatment for depression. As the left prefrontal cortex activity is linked to depression, rTMS induces blood flow in the left dorsolateral prefrontal cortex (dlPFC). Long acting psychostimulants are sometimes prescribed as an adjunctive antidepressant treatment throughout rTMS therapy. We used rTMS to treat resistant depression in a middle-aged male patient over a twelve month period where a psychostimulant medication was also discontinued. He had been consistently taking duloxetine 60 mg BID, clonazepam 0.5 mg BID, and dextroamphetamine-amphetamine extended release 30 mg once daily prior to the onset of rTMS treatment. The patient …

Acupuncture Treatment For Post-Stroke Depression: Intestinal Microbiota And Its Role, Hailun Jiang, Shizhe Deng, Jieying Zhang, Junjie Chen, Boxuan Li, Weiming Zhu, Menglong Zhang, Chao Zhang, Zhihong Meng

Faculty, Staff and Student Publications

Stroke-induced depression is a common complication and an important risk factor for disability. Besides psychiatric symptoms, depressed patients may also exhibit a variety of gastrointestinal symptoms, and even take gastrointestinal symptoms as the primary reason for medical treatment. It is well documented that stress may disrupt the balance of the gut microbiome in patients suffering from post-stroke depression (PSD), and that disruption of the gut microbiome is closely related to the severity of the condition in depressed patients. Therefore, maintaining the balance of intestinal microbiota can be the focus of research on the mechanism of acupuncture in the treatment of …

The Influence Of Child Maltreatment In The Manifestation Of Anxiety And Depressive Symptoms At The Age 18, Maria J. Velasquez

LSU Master's Theses

Child maltreatment affects thousands of children and adolescents every year. This phenomenon is multidimensional, meaning there are different subtypes (i.e., physical abuse, sexual abuse, emotional abuse, and neglect) known to predict various mental health issues, including depression and anxiety. While previous research has investigated mental health outcomes in maltreated youth, results may vary based on the dimensions of abuse considered. This study aims to expand on previous literature to examine how a history of child maltreatment subtypes influences the manifestation of anxiety and depressive symptoms in youth at age 18. The current study uses secondary data analysis of the Longitudinal …

A Participatory Study Of College Students’ Mental Health During The First Year Of The Covid-19 Pandemic, Chulwoo Park, Melissa Mcclure Fuller, Thea Marie Echevarria, Kim Nguyen, Daisy Perez, Hufsa Masood, Tasneem Alsharif, Miranda E. Worthen

Faculty Research, Scholarly, and Creative Activity

Introduction: The COVID-19 pandemic has negatively impacted college students’ mental health and wellbeing. Even before the pandemic, young adults reported high mental health morbidity. During the pandemic, young adult college students faced unprecedented challenges, including campus closure and a pivot to fully online education.

Methods: This study employed a novel participatory approach to a Course-based Undergraduate Research Experience (CURE) in an introductory epidemiology course to examine factors students considered important regarding their experience during the pandemic. Two groups of undergraduate students enrolled in this course (one in Fall 2020 and another in Spring 2021) and participated in the CURE. A …

Preclinical Perspectives On The Mechanisms Underlying The Therapeutic Actions Of Psilocybin In Psychiatric Disorders, Andreas B. Wulff, Charles D. Nichols, Scott M. Thompson

School of Medicine Faculty Publications

Psychedelic compounds have shown extraordinary potential in treating a wide range of neuropsychiatric disorders. Psilocybin, for example, has now been shown in several clinical trials to induce a rapid (within days) and persistent (3–12 months) improvement in human treatment-resistant depression and other neuropsychiatric conditions. Here we review the preclinical models and experimental approaches that have been used to study the neurobiological actions of psychedelic drugs. We further summarize the insights these studies have provided into the possible mechanisms underlying the induction of their therapeutic actions, including the receptors to which psychedelics bind and the second messenger signaling cascades that they …

Affective Depression Mediates Ptsd To Suicide In A Sample Of Treatment-Seeking First Responders, James Whitworth, Jeanine Galusha, Jose Carbajal, Warren Ponder, Donna Schuman

Faculty Publications

Objective: The aim of this study was to examine the associations of comorbid

posttraumatic stress disorder (PTSD), affective or somatic depression, and

suicide among first responders (FRs). Method: We used baseline data from

FRs (N = 232) who sought services at a nonprofit mental health agency specializing

in treating trauma exposed FRs. We conducted two PROCESS simple

mediation models with PTSD as the predictor, affective depression and somatic

depression as the mediators, and suicidality as the dependent variable.

Results: Affective depression significantly mediated the relationship between

PTSD and suicidality, whereas somatic depression did not. The direct effect …

A Two-Night Polysomnography Preliminary Study In Pregnant Women With Insomnia: Suicidal Ideation And Nocturnal Cognitive Arousal Prospectively Predict Objective Nocturnal Wakefulness, David A. Kalmbach, Philip Cheng, Thomas Roth, Cynthia Fellman-Couture, Chaewon Sagong, Christopher L. Drake

Sleep Medicine Articles

STUDY OBJECTIVES: Sleep disruption is common in pregnancy, manifesting as insomnia in half of pregnant women as well as increasing objective nocturnal wakefulness across gestation. Despite potential overlap between insomnia and objective sleep disturbances in pregnancy, objective nocturnal wakefulness and its potential contributing factors remain uncharacterized in prenatal insomnia. The present study described objective sleep disturbances in pregnant women with insomnia and identified insomnia-related predictors of objective nocturnal wakefulness.

METHODS: Eighteen pregnant women with clinically significant insomnia symptoms (n = 12/18 with DSM-5 insomnia disorder) underwent two overnight polysomnography (PSG) studies. Insomnia symptoms (Insomnia Severity Index), depression and suicidal ideation …

The Association Of Emotional Eating With Overweight/Obesity, Depression, Anxiety/Stress, And Dietary Patterns: A Review Of The Current Clinical Evidence, Antonios Dakanalis, Maria Mentzelou, Souzana K. Papadopoulou, Dimitrios Papandreou, Maria Spanoudaki, Georgios K. Vasios, Eleni Pavlidou, Maria Mantzorou, Constantinos Giaginis

All Works

(1) Background: Emotional eating is considered as the propensity to eat in response to emotions. It is considered as a critical risk factor for recurrent weight gain. Such overeating is able to affect general health due to excess energy intake and mental health. So far, there is still considerable controversy on the effect of the emotional eating concept. The objective of this study is to summarize and evaluate the interconnections among emotional eating and overweight/obesity, depression, anxiety/stress, and dietary patterns; (2) Methods: This is a thorough review of the reported associations among emotional eating and overweight/obesity, depression, anxiety/stress, and dietary …

Understanding The Health-Related Quality Of Life Of People Living With Hiv Based On Sexual Orientation, Rico Januar Sitorus, Nyoman Yudi Antara, Reymart Sangalang, Merry Natalia Panjaitan, Nelsensius Klau Fauk

Kesmas

Human immunodeficiency virus (HIV) infection has detrimental impacts on the lives of different population groups living with HIV, including men who have sex with men (MSM). Using the World Health Organization Quality of Life questionnaire, this study aimed to assess the health-related quality of life of men living with HIV with different sexual orientations and to determine the dominant influential factors. This cross-sectional study involved 206 men living with HIV. They were recruited from the Sriwijaya Plus Foundation and a medical facility that provided antiretroviral therapy. The data were analyzed using Chi-square and binomial logistic regression. The analysis showed that …

Symptoms Of Depression And Anxiety And Subsequent Use Of Nicotine And Thc In Electronic Cigarettes, Stephanie Clendennen, Jacob Smith, Aslesha Sumbe, Baojiang Chen, Anna Wilkinson

School of Medicine Publications

Background: This study examines whether symptoms of depression, anxiety, or comorbid depression and anxiety are associated with future use of nicotine or THC in e-cigarettes.

Methods: Data were from an online survey of youth and young adults in urban areas of Texas with complete data (n = 2,307) in spring 2019 (baseline) and spring 2020 (12-month follow-up). Multivariable logistic regression models examined associations between self-reported symptoms of depression, anxiety, or comorbid depression and anxiety at baseline and past 30-day e-cigarette use with nicotine or THC at 12-month follow-up. Analyses adjusted for baseline demographics and baseline past 30-day e-cigarette, combustible tobacco, …

Experiences Of Covid-19-Related Racism And Impact On Depression Trajectories Among Racially/Ethnically Minoritized Adolescents, Sabrina R. Liu, Elysia Poggi Davis, Anton M. Palma, Hal S. Stern, Curt A. Sandman, Laura M. Glynn

Psychology Faculty Articles and Research

Purpose

In 2020, racially/ethnically minoritized (REMD) youth faced the “dual pandemics” of COVID-19 and racism, both significant stressors with potential for adverse mental health effects. The current study tested whether short- and long-term trajectories of depressive symptoms from before to during the COVID-19 pandemic differed between REMD adolescents who did and did not endorse exposure to COVID-19-era-related racism (i.e., racism stemming from conditions created or exacerbated by the COVID-19 pandemic).

Methods

A community sample of 100 REMD adolescents enrolled in an ongoing longitudinal study of mental health was assessed before and during the COVID-19 pandemic. Participants were 51% girls, mean …

Music Education Majors And Mental Health: A Follow-Up Study, Philip D. Payne

Research & Issues in Music Education

Music education majors across the United States (N = 1029) self-reported indicators of depression, anxiety, personality, and stress. According to the results, music education majors are highly busy, and report elevated levels of stress as compared to their peers. Semester enrollment averages include: 18.5 hours (including 0 credit courses) a semester, rehearsing an average of 9.08 hours a week, and a majority of whom work an average of 13-15 hours a week all while reporting high perceived stress levels. Furthermore, 74% of respondents required additional screening on the DSM-V for depression with over 70% exhibiting symptoms of moderate or severe …

Emotional Distress, Self-Management, And Glycemic Control Among Participants Enrolled In The Glycemia Reduction Approaches In Diabetes: A Comparative Effectiveness (Grade) Study, Jeffrey S Gonzalez, Heidi Krause-Steinrauf, Ionut Bebu, Gladys Crespo-Ramos, Claire J Hoogendoorn, Aanand D Naik, Andrea Waltje, Elizabeth Walker, Dominic Ehrmann, Janet Brown-Friday, Andrea Cherrington

Faculty, Staff and Student Publications

OBJECTIVE: We examined emotional distress in relation to metformin adherence, overall diabetes self-management, and glycemic control among adults with early type 2 diabetes (T2DM) enrolled in the GRADE study.

METHODS: Linear regression models examined cross-sectional associations of baseline depression symptoms and diabetes distress with adherence to metformin, self-management, and HbA1c, adjusting for covariates. Cognitive-affective (e.g., sadness) and somatic (e.g., sleep/appetite disturbance) depression symptoms and diabetes distress subscales were also examined.

RESULTS: This substudy of 1,739 GRADE participants (56 % Non-Hispanic White, 18 % Non-Hispanic Black, 17 % Hispanic, 68 % male, mean[SD] age = 57.96[10.22] years, diabetes duration = 4.21[2.81] …

Is A Genetic Diathesis For Poor Nutrition Becoming More Crucial Due To The Uniformity Of Covid Social Stress?, M. Catherine Desoto

Faculty Publications

The important role of nutrition in proper neural functioning and mental health has seen wider acceptance, but is still sadly under recognized given the existent body of research. This Special Issue was designed to unite authoritative information on this topic in one volume. This editorial provides an overview of the issue, and suggests that the combination of social isolation, lack of exercise, and remaining indoors that overtook industrialized societies during 2020 are specific factors expected to change the Gene × Environment interactions for anxiety and depression. Importantly, the recent environmental changes may make biological diatheses for nutritional deficiencies even more …

A Next-Generation Approach To Mental Health Outcomes: Treatment, Time, And Trajectories, Mario Montelongo, Jaehoon Lee, Edward Poa, Robert Boland, Katrina A Rufino, Michelle Patriquin, Hyuntaek Oh

Staff and Researcher Publications

Over the last several decades, inpatient psychiatric length of stay (LOS) has been greatly reduced to the detriment of patients. Latent variable mixture modeling, can be used to improve the quality of care for patients by identifying unobserved subgroups and optimize treatment variables, including LOS. This study had three objectives (1) to replicate the findings made by Oh et al. in a distinct sample, (2) to examine demographic differences related to inpatient treatment trajectories, and (3) to relate additional variables to each trajectory. We collected data on six key mental illness factors and information on felonies, misdemeanors, history of stopping …

Effortful Control Moderates The Relation Between Negative Emotionality And Child Anxiety And Depressive Symptom Severity In Children With Anxiety Disorders, Elizabeth M Raines, Andres G Viana, Erika S Trent, Haley E Conroy, Karina Silva, Michael J Zvolensky, Eric A Storch

Center for Medical Ethics and Health Policy Staff Publications

The present study investigated the interactive effect of reactive (negative emotionality) and regulatory (effortful control) aspects of temperament in the prediction of child anxiety and depressive symptoms. Clinically anxious children and their mothers completed a battery of questionnaires that included self- and mother-ratings of child effortful control, negative emotionality, anxiety, and depressive symptoms. Multiple regression analyses were conducted to examine the moderating effect of effortful control on the relation between negative emotionality and child anxiety and depressive symptom severity. The interaction between negative emotionality and effortful control was statistically significant and simple slopes revealed that as effortful control increased, the …

An Examination Of Discrimination On Stress, Depression, And Oppression-Based Trauma During The Covid-19 Pandemic And The Racial Awakening Of 2020, Ardhys N. De Leon, Jacqueline Woerner, Robert D. Dvorak, Jonathan Cox, Tatiana D. Magri, Emma R. Hayden, Manik Ahuja, Angela M. Haeny

ETSU Faculty Works

Background

Methods

The End Of The “Chemical Imbalance” Theory Of Depression - What Now?, Austin Brown

Population Health Research Brief Series

For decades, those diagnosed with depression have been told they suffer from a “chemical imbalance.” This explanation involves neurotransmitters, such as serotonin, thought to be the main neurochemical responsible for major depressive disorders. Growing research challenges this theory and the need for medication therapies for depressive symptoms. This brief summarizes new findings examining the theory that depression is caused by a chemical imbalance and calls for healthcare professionals and patients to consider the market influences and social structures that impact health.