Digital Commons Network^™

Longitudinal Associations Of Epigenetic Aging With Cognitive Aging In Hispanic/Latino Adults From The Hispanic Community Health Study/Study Of Latinos, Myriam Fornage, Wassim Tarraf, Rui Xia, Adriana Ordonez, Tamar Sofer, Freddie Márquez, Bharat Thyagarajan, Gregory A Talavera, Linda C Gallo, Charles Decarli, Hector M González

The Brown Foundation: Institute of Molecular Medicine

Due to the paucity of longitudinal DNA methylation data (DNAm), especially among Hispanic/Latino adults, the association between changes in epigenetic clocks over time and cognitive aging phenotypes has not been investigated. This longitudinal study included 2671 Hispanic/Latino adults (57 years; 66% women) with blood DNAm data and neurocognitive function assessed at two visits ~7 years apart. We evaluated the associations of 5 epigenetic clocks and their between-visit change with multiple measures of cognitive aging that included a global and domain-specific cognitive function score at each visit, between-visit change in global and domain-specific cognitive function score, and MCI diagnosis at visit …

Improving The Assessment Of Functional Ability In Older Adults, Aneela Rahman

Dissertations, Theses, and Capstone Projects

Deficits in instrumental activities of daily living (IADL) are a hallmark of dementia, and the unprecedented aging of the population strongly motivates early identification of older adults at-risk for functional decline. In 2015, the White House Conference on Aging emphasized the need to improve detection of diminished capacity across important areas of functioning. To date, there is very limited research on early IADL changes in cognitively unimpaired (CU) individuals and those with subjective cognitive decline (SCD) and mild cognitive impairment (MCI), who may be in early preclinical dementia stages. Additionally, little is known about how changes in functional brain networks …

Heightened Risk: Childhood Trauma And Anticipatory Grief Exacerbate The Impact Of Loneliness On Depressive Symptoms And Lps-Stimulated Cytokines In Dementia Caregivers, Kelly N Brice, Jensine Paoletti-Hatcher, E Lydia Wu-Chung, Vincent D Lai, Daniel L Argueta, Michelle A Chen, Itee Mahant, Bryan T Denny, Charles Green, Luis D Medina, Paul Schulz, Jennifer Stinson, Samantha K Henry, Cobi Heijnen, Christopher P Fagundes

Faculty, Staff and Student Publications

Dementia spousal caregivers are at a disproportionate risk for adverse mental and physical health outcomes. Loneliness is associated with depressive symptoms and proinflammatory cytokine production among caregivers. Additionally, childhood trauma, anticipatory grief, and poor sleep quality are all associated with enhanced stress reactivity. This study used a cross-sectional design to investigate whether loneliness is associated with proinflammatory cytokine production and depressive symptoms in caregivers, and whether these relationships are strongest among caregivers who report high levels of childhood trauma, high amounts of anticipatory grief, or poor sleep quality. A sample of 111 dementia spousal caregivers provided blood samples and completed …

Implementation Of The Montreal Cognitive Assessment (Moca) Tool For Early Detection Of Dementia, Nadege Djeukui

DNP and Student Works

As the population ages, the prevalence of cognitive impairment increases (Hilsabeck et al., 2024). There are about 10 million new cases reported annually, and over 55 million people worldwide are currently living with dementia, a number projected to increase to 78 million by 2030 (WHO, 2023). Dementia is a growing public health concern that is often underdiagnosed in primary care, leading to missed opportunities for early intervention, care coordination, and patient support. Early detection of dementia is crucial for timely intervention, effective care planning, and enhanced patient outcomes. Early identification of cognitive impairment is critical in improving patient outcomes, enhancing …

Is Therapeutic Lying Ethically Justifiable If It Leads To Improved Care?, Deborah Murphy

Journal of Social Care

Problem statement

Although therapeutic lying is used extensively as an intervention in dementia care, its use is ethically controversial, firstly, because lying is usually viewed negatively, and secondly, because people with dementia are an especially vulnerable cohort. It is claimed that therapeutic lying improves wellbeing and supports a person-centred approach to dementia care.

Research Question

Is lying to people with dementia ethically justifiable if it leads to improved care?

Aim

To investigate whether care can be improved using therapeutic lies, to explore the ongoing ethical debate around its justification and to examine whether therapeutic lies support person-centred interventions.

Method

This …

The Global Neurodegeneration Proteomics Consortium: Biomarker And Drug Target Discovery For Common Neurodegenerative Diseases And Aging, Farhad Imam, Rowan Saloner, Jacob W Vogel, Varsha Krish, Gamal Abdel-Azim, Muhammad Ali, Lijun An, Federica Anastasi, David Bennett, Alexa Pichet Binette, Adam L Boxer, Martin Bringmann, Jeffrey M Burns, Carlos Cruchaga, Jeff L Dage, Amelia Farinas, Luigi Ferrucci, Caitlin A Finney, Mark Frasier, Oskar Hansson, Timothy J Hohman, Erik C B Johnson, Mika Kivimaki, Roxanna Korologou-Linden, Agustin Ruiz Laza, Allan I Levey, Inga Liepelt-Scarfone, Lina Lu, Niklas Mattsson-Carlgren, Lefkos T Middleton, Kwangsik Nho, Hamilton Se-Hwee Oh, Ronald C Petersen, Eric M Reiman, Oliver Robinson, Jeffrey D Rothstein, Andrew J Saykin, Artur Shvetcov, Chad Slawson, Bart Smets, Marc Suárez-Calvet, Betty M Tijms, Maarten Timmers, Fernando Vieira, Natalia Vilor-Tejedor, Pieter Jelle Visser, Keenan A Walker, Laura M Winchester, Tony Wyss-Coray, Chengran Yang, Niranjan Bose, Simon Lovestone, The Global Neurodegeneration Proteomics Consortium (Gnpc)

Faculty, Staff and Student Publications

More than 57 million people globally suffer from neurodegenerative diseases, a figure expected to double every 20 years. Despite this growing burden, there are currently no cures, and treatment options remain limited due to disease heterogeneity, prolonged preclinical and prodromal phases, poor understanding of disease mechanisms, and diagnostic challenges. Identifying novel biomarkers is crucial for improving early detection, prognosis, staging and subtyping of these conditions. High-dimensional molecular studies in biofluids ('omics') offer promise for scalable biomarker discovery, but challenges in assembling large, diverse datasets hinder progress. To address this, the Global Neurodegeneration Proteomics Consortium (GNPC)-a public-private partnership-established one of the …

Health Patterns Of Dementia Caregivers With Chronic Pain: Latent Profile Analysis Of The Promis-29 Measure, Shelbie G. Turner, Dakota D. Witzel, Shana Garza, Karl Pillemer, M Carrington Reid

Human Genetics Publications

We identified patterns of health and functioning in a national sample of dementia family caregivers experiencing chronic pain (N = 273). Utilizing latent profile analysis of the 29-item Patient-Reported Outcomes Measurement Information System (PROMIS-29), we identified three discrete groups: an average group (48%), a low health challenges group (30%), and a high health challenges group (22%). Women were more likely to be in the high (vs. low) health challenges group. There are discrete health patterns of caregivers with chronic pain, with over 20% reporting comorbid poor health and functioning that may negatively affect caregiving quality. Screening caregivers for high …

The Experience Of People Living With Dementia (Pwd) In Participating In Virtual Cognitive Stimulation Therapy (Vcst)—A Qualitative Systematic Review, Hau Ying Chan, Heather Bullen

Student Journal of Occupational Therapy

Background: This systematic review aims to explore the experiences of people living with dementia (PwD) participating in virtual cognitive stimulation therapy (vCST). With the global shift of cognitive stimulation therapy (CST) online during the COVID-19 pandemic, little research has explored how PwD experience telehealth interventions. This is the first qualitative systematic review on the experience of PwD participating in vCST.

Methods: Following the Joanna Briggs Institute (JBI) methodology for qualitative systematic reviews, a comprehensive search was conducted across six databases and the grey literature from January 1, 2013, to August 31, 2023.

Conclusion: Two synthesized findings were identified from two …

Computational Thinking As A Novel Framework For Enhancing Cognitive Organization In Older Adults With Cognitive Frailty (Letter To The Editor), Daisuke Akiba

Publications and Research

As aging populations grow, especially in high-income nations, the burden of dementia-related care continues to escalate both economically and socially. In response, this article introduces Computational Thinking (CT) as a novel, non-pharmacological framework to support cognitive organization in older adults experiencing cognitive frailty. Though CT has gained traction in fields like PK-16 education, including special education, for enhancing executive function and problem-solving, it has not yet been applied to geriatric- or memory-care contexts. This perspective proposes that CT’s core components (i.e., decomposition, pattern recognition, abstraction, and algorithmic thinking) may align with residual cognitive strengths in mild-to-moderate dementia, offering a strengths-based, …

The Virtual Kitchen Challenge: Psychometric Validation In Cognitively Healthy And Impaired Older Adults, Ross M. Divers

LSU Doctoral Dissertations

Decline in everyday functioning is core diagnostic criteria for mild cognitive impairment (MCI) and dementia. While historically, MCI was considered a stage of generally persevered everyday functioning, it is now widely accepted that subtle though clinically meaningful changes in everyday function can be observed and are predictive of increased risk of future decline and conversion to dementia. Despite this, self and informant report questionnaires of everyday function largely fail to capture this subtle decline in those with MCI, while performance-based measures that may be able to capture this decline are rarely administered clinically due to their laborious administration. Performance-based measures …

Enhancing Dementia Classification For Diverse Demographic Groups: Using Vision Transformer-Based Continuous Scoring Of Clock Drawing Tests., Mengyao Hu, Yi Lu Murphey, Tian Qin, Edmundo R Melipillán, Laura B Zahodne, Richard Gonzalez, Vicki A Freedman

Faculty, Staff and Student Publications

Objectives: Alzheimer's disease and related dementias significantly affect older adults' quality of life. The clock-drawing test (CDT) is a widely used dementia screening tool due to its ease of administration and effectiveness. However, manual CDT-coding in large-scale studies can be time-intensive and prone to coding errors and is typically limited to ordinal responses. In this study, we developed a continuous CDT score using a deep learning neural network (DLNN) and evaluated its ability to classify participants as having dementia or not.

Methods: Using a nationally representative sample of older adults from the National Health and Aging Trends Study (NHATS), we …

Dementia Care: The Role Of Experiential Learning In Nursing Education, Jeannie Simpson

Wisdom & Compassion: The LUSON Journal

The escalating global prevalence of dementia necessitates enhanced educational strategies to prepare nursing students to care effectively for individuals living with dementia. Traditional methods in nursing education predominantly focus on pharmacological treatments and basic caregiving strategies, often neglecting innovative approaches like the Music & Memory® program, Virtual Dementia Tour®, and Montessori dementia. By including these innovative approaches, future nurses will be better equipped to develop and implement person-centered care for individuals living with dementia to improve their quality of life. The integration of these approaches will also meet the growing demands of dementia care, aligning with global health mandates.

Art, Play, And Neuroplasticity: Advancing Dementia Care Through Art-Enriched Environments, Piper Hutson, James Hutson

Faculty Scholarship

Dementia represents a global public health crisis, characterized not only by progressive memory loss but by a pervasive decline in cognitive flexibility, social functioning, and overall quality of life. Traditional therapeutic modalities, often limited to pharmacological management and cognitive training, have yielded only modest gains in symptom mitigation and patient well-being. Recent advances in neuroscience have illuminated the brain‘s capacity for neuroplasticity—its inherent ability to adapt, reorganize, and form new neural connections even in advanced age and the presence of neurodegenerative conditions. This emerging understanding invites a critical re-evaluation of dementia care strategies, highlighting the potential of non-pharmacological interventions to …

Variation In The Potentially Inappropriate Use Of Antipsychotic And Benzodiazepine Medications Among Individuals Receiving Residential Medication Management Reviews, Mouna J. Sawan, Alexander J. Clough, Jodie Hillen, Andrew R. Zullo, Daniela C. Moga, Natalie Soulsby, Danijela Gnjidic

Epidemiology and Environmental Health Faculty Publications

Objectives To describe the variation in the use of potentially inappropriate antipsychotic and benzodiazepine medications in residents who have received a medication review and to evaluate the extent to which this variation is associated with aged care home (ACH) and resident characteristics. Methods This cross-sectional, retrospective study used pharmacist-extracted data from 15,442 residents across 342 Australian ACHs who had a medication review during 2019. The proportion of residents receiving ≥1 potentially inappropriate antipsychotic and benzodiazepine medication according to Beers criteria were classified into quintiles by facility usage (Q1-Q5). Quintile characteristics were compared using descriptive analysis of facility and resident data. …

The Specialist Dementia Care Program In Australia: Evidence To Date On A Home-Like Model Of Care For People With Very Severe Behaviours And Psychological Symptoms Of Dementia, Mustafa Atee, Srivalli Vilapakkam Nagarajan, Rebecca Lloyd, Stephen Macfarlane, Angela Raguz, Thomas Morris

Research outputs 2022 to 2026

Objectives: Behaviours and psychological symptoms of dementia (BPSD) have a serious impact on care and health outcomes, such as inappropriate pharmacotherapy and impaired quality of life. These symptoms are common across care settings but are more prevalent in residential aged care homes (RACHs). BPSD such as aggression and psychosis may pose a high risk of harm to residents, co-residents, caregivers and families, and the severe forms of these BPSD are linked to RACH premature admission. When people with very severe BPSD in Australia cannot be cared for in mainstream RACHs, the Specialist Dementia Care Program (SDCP) is offered. This article …

Staff Education To Improve Quality Of Life For Patients With Dementia, Vanessa Ann Soda

Walden Dissertations and Doctoral Studies

Dementia is a chronic neurodegenerative disease that is incurable and unpredictable. Patients with dementia experience a decline in functional abilities, communication, and social skills. Fifty-five million people worldwide live with dementia with over 6.9 million people over 65 years of age diagnosed in the United States. The practice problem identified by a 25-bed assisted living facility in the north-central United States was staff’s lack of knowledge of dementia diagnosis, person-centered care approaches, and optimal care strategies supporting a positive quality of life for patients with dementia. The practice-focused question addressed whether an education program consisting of evidence-based practices using the …

The Neuropsychiatric Value Of Expressive Arts Therapy Integrated With Psychedelic-Assisted Therapy In Treating Alzheimer's Disease And Related Disorders (Adrd), Alicia C. Hesse-Cleary

Expressive Therapies Theses

Neurodegenerative conditions, including Alzheimer's disease (AD), Parkinson's disease, and other dementias, are progressive disorders that lead to white matter damage in the brain, resulting in structural and functional consequences that disrupt neuronal pathways and contribute to significant cognitive and behavioral impairments. Alzheimer’s disease is the most common form and a leading cause of death among older adults. Nearly 97% of patients experience neuropsychiatric symptoms, which are incredibly challenging to treat effectively as the disease progresses and, in some cases, may be untreatable with pharmaceuticals. This situation significantly increases caregiver burden and healthcare costs. Traditional pharmacological treatments for these conditions have …

Improving Brain Health: Exercise As A Tool For Enhancing Executive Function And Reducing Stress In Older African Americans, Destiny Ellise Ramos

Theses, Dissertations and Culminating Projects

Older African American (AA) adults face disproportionately higher risk of stress and Alzheimer's Disease and Related Dementias (ADRD) compared to other racial and ethnic groups, yet they remain underrepresented in intervention-based research. Previous research has suggested aerobic exercise may reduce stress and benefit executive functioning, which is among the first cognitive domains to be affected in ADRD; however, no studies to date have directly tested the impact of aerobic vs. non-aerobic exercise in older AAs at high risk for developing ADRD. The current study evaluated the effects of a group-based cardio dance fitness (CDF) exercise intervention versus a strength, flexibility, …

Dabigatran Reduced Acute Microgliosis In A Mouse Model With Tbi, Nicholas R. Eltman, Rashmeena Abbasi, Mary C. Kosciuk, Syed Ahmed, Jose L. Pascual, Randel L. Swanson, Nimish K. Acharya

Rowan-Virtua Research Day

Objective:

The study objective was to investigate the acute anti-inflammatory effects of dabigatran in a preclinical mouse controlled cortical impact (CCI) model of severe traumatic brain injury (TBI).

Design

Mice were separated into three groups: controlled cortical impact (CCI) with dabigatran (drug treatment, n=5), CCI with saline (positive control, n=5), and sham CCI without saline or dabigatran (negative control, n=3). Dabigatran (80mg/kg) or saline was administered orally at 2, 10, 18, 26, 34, and 42 hours following experimental CCI in the drug treatment or positive control groups, respectively. Animals in the negative control group received sham CCI only. 48h following …

Reforming Pensions In Africa: Addressing Coverage, Payout Disparities, And Dementia Outcomes For Sustainable Aging, Cyprian Mostert, Catherine Ajalo, David Andai

Brain and Mind Institute

No abstract provided.

Living In Essex: A Community Needs Assessment, Sue Berger, Ceara Somerville, Caitlin E. Coyle

Center for Social and Demographic Research on Aging Publications

This report describes research undertaken by the Center for Social & Demographic Research on Aging (CSDRA) within the Gerontology Institute at the University of Massachusetts Boston, on behalf of the Town of Essex. The goals of this project were to investigate the needs, interests, preferences, and opinions of Essex residents age 18 or older by engaging the community regarding their experiences and needs relevant to the Council on Aging’s (COA’s) objective to identify and serve the needs of all Essex citizens 60 and older.

Nursing Faculty Experiences Of Teaching Dementia Care: A Transcendental Phenomenological Study, Jeannie Simpson

Doctoral Dissertations and Projects

The purpose of this phenomenological study was to explore the experiences of nursing faculty teaching dementia care to nursing students in Texas. The theory guiding this study was Kolb’s experiential learning theory as it offers a structured framework for examining how experiences lead to learning. This theory also introduced the concept of the Experiential Educator profile, specifically delineating the role of educators in facilitating knowledge acquisition (Kolb, 2014). This study bridged the gap in existing literature regarding the experiences of nursing faculty in teaching dementia care to nursing students and provided a comprehensive look at dementia education in nursing schools. …

Design Solutions For Common Problems In Senior Living Facilities, Mary Schmidt

Senior Honors Theses

With the aging population of the United States, the prevalence of dementia rises along with its challenges for individuals in long-term care facilities. As cognitive function deteriorates, dementia patients face growing difficulties in performing daily activities. Common issues such as wayfinding, wandering, exit attempts, agitation, and a generally low quality of life plague most dementia patients at long-term care facilities. Design features can improve quality of life, safety, and coherence for residents with dementia at assisted living facilities. This paper examines existing research to present various design strategies that can enhance daily life for dementia patients in long-term care facilities. …

Early-Stage Major Neurocognitive Disorder: A Case Study Of The Experiences Of Elder Men Who Attended A Peer-Led Support Group, Laurie Knight Kjoller

Doctoral Dissertations and Projects

The purpose of this qualitative exploratory case study was to understand how elder men ages 65 and older with a diagnosis of early-stage major neurocognitive disorder experienced their participation in a peer-led support group series held at a neurology clinic in Barnstable, Massachusetts. The theory guiding this study asserts elder individuals contending with a chronic and debilitating illness like major neurocognitive disorder need to experience a sense of belonging and psycho-emotional support to attain resilience and quality of life and is found in the works of Hassani, Izadi-Avanji, Rakhshan, & Majd (2017) as it relates to the experience of elder …

Elder Mistreatment Within Stroke Family Caregiving, Carina Katigbak, Wesley R Browning, Sean Savitz, Carolyn E Z Pickering

Faculty, Staff and Student Publications

This secondary data analysis sought to identify characteristics associated with mistreatment among chronic stroke survivors who transition to dementia. We examined baseline data from a multi-time series survey study (n = 453; where caregivers of those with stroke n = 107, and those without stroke, n = 346) on caregiving experiences influencing dementia family caregivers’ abusive or neglectful behaviors. Inferential statistical analysis indicated that baseline mistreatment rates were similar across stroke and non-stroke subgroups, though this finding was not significant. Caregiver depression was significantly associated with mistreatment. Multi-morbidity, prescription medication use, and limited mobility were more common among stroke …

A Comparison Study Of Sensory Processing In Older Adults With And Without Dementia, Medi̇ne Nur Özata Değerli̇, Di̇dem Karaduman, Burcu Balam Doğu, Onur Altuntaş

Turkish Journal of Medical Sciences

Background/aim: Sensory processing is affected by aging, and dementia may lead to changes in sensory processing. This study aimed to examine the differences in sensory processing and sensory modulation between older adults with and without dementia.Materials and methods: This study was designed as a comparative study of community-dwelling older adults aged 65 years and older with and without dementia. Participants and their caregivers were recruited at the occupational therapy clinic of a public hospital. They completed a sociodemographic information form and the Adolescent/Adult Sensory Profile to assess sensory processing and sensory modulation.Results: The study included 120 older adults (60 with …

Predictors Of Bi-Directional Transitions From Mild Cognitive Impairment In A Diverse Cohort, Mitzi M. Gonzales, Roman Fernandez, Sarah Kremen, Zaldy S. Tan, Amy E. Werry, Xueqiu Jian, John Hart, Donald Royall, Gladys Maestre, Sara Espinoza

School of Medicine Publications

Trajectories following a diagnosis of mild cognitive impairment (MCI) are varied and may fluctuate over time. Among diverse ethnic and racial groups, social factors, medical comorbidities, and biases in assessment procedures may contribute to greater heterogeneity in the MCI diagnostic category and affect its prognostic significance for dementia. The study goal was to evaluate the frequency and variables associated with MCI transitions among non-Hispanic White (NHW) and Latinx older adults. Multistate Markov models characterized transitions across diagnostic states (cognitively unimpaired (CU), MCI, dementia) over ten years. Variables associated with transitions were assessed using hazard ratios (HR) and 95% confidence intervals …

Virtual Reality Game-Based Training For Preventing Falls Among Community-Dwelling Older Adults With Mild Cognitive Impairment: A Pilot Randomized Control Trial Study, Benson Ip

School of Health Professions

Using a Virtual Reality (VR) game-based application represents an innovative approach to falls prevention in community aged care service. The study investigated the effects of VR training on falls prevention among community-dwelling older adults with mild cognitive impairment. A pilot randomized controlled trial was conducted to compare the effects of full-immersive VR training with group-based exercise (Baduanjin) training on falls prevention. Eighteen participants were recruited through convenience sampling and were randomly assigned to either the VR group or the non-VR exercise group. Both groups participated in 16 falls prevention training sessions over eight weeks. Participants, identified with mild cognitive impairment …

Occupational Therapy In Caregiver Education And Dementia Care, Sophie Winter

Entry Level Occupational Therapy Doctoral Capstone Projects Class of 2025

The doctoral capstone project addresses education on optimal care for individuals with dementia to increase occupational performance and limit excess disability through training sessions with caregivers. The community program created took place at a community memory care adult day program. The bulk of the project focuses on education for caregivers of those with dementia through creating educational handouts, practicing through trainings, and creating personally tailored activities for cognition maintenance and participation. Caregiver manuals were made to address caregiver burnout, education, and competency. The other major part of this capstone was program development assessing the needs of the population and creating …

Perceived Obligations Of Older Partners In Living-Apart-Together Relationships, Allison M. Martin, Timothy S. Killian

Discovery, The Student Journal of Dale Bumpers College of Agricultural, Food and Life Sciences

Older and middle-aged adults are increasingly in Living-Apart-Together (LAT) relationships characterized by committed romantic relationships without marriage and cohabitation. Because of assumptions that older adults will receive family caregiving as they grow older and need caregiving, it is not clear how people are likely to perceive obligations to provide caregiving assistance. As adults move into old age and incidence rates of Alzheimer’s Disease or Related Dementia (ADRD) increase, questions about the availability of family members to provide needed assistance are complicated by LAT relationships. The purpose of this study was to examine perceived obligations to provide assistance to older adults …