Digital Commons Network^™

Combining Biology-Based And Mri Data-Driven Modeling To Predict Response To Neoadjuvant Chemotherapy In Patients With Triple-Negative Breast Cancer, Casey E Stowers, Chengyue Wu, Zhan Xu, Sidharth Kumar, Clinton Yam, Jong Bum Son, Jingfei Ma, Jonathan I Tamir, Gaiane M Rauch, Thomas E Yankeelov

Faculty, Staff and Student Publications

Purpose

To combine deep learning and biology-based modeling to predict the response of locally advanced, triple-negative breast cancer before initiating neoadjuvant chemotherapy (NAC).

Materials and Methods

In this retrospective study, a biology-based mathematical model of tumor response to NAC was constructed and calibrated on a patient-specific basis using imaging data from patients enrolled in the MD Anderson A Robust TNBC Evaluation FraMework to Improve Survival trial (ARTEMIS; ClinicalTrials.gov registration no. NCT02276443) between April 2018 and May 2021. To relate the calibrated parameters in the biology-based model and pretreatment MRI data, a convolutional neural network (CNN) was employed. The CNN …

Combining Biology-Based And Mri Data-Driven Modeling To Predict Response To Neoadjuvant Chemotherapy In Patients With Triple-Negative Breast Cancer, Casey E Stowers, Chengyue Wu, Zhan Xu, Sidharth Kumar, Clinton Yam, Jong Bum Son, Jingfei Ma, Jonathan I Tamir, Gaiane M Rauch, Thomas E Yankeelov

Faculty, Staff and Student Publications

Triple-negative breast cancer (TNBC) is an aggressive breast cancer subtype associated with limited targeted treatment options, heterogeneous treatment response, and high risk of early recurrence. Artificial intelligence (AI) has rapidly emerged as a powerful tool to address key clinical challenges in TNBC across diagnosis, treatment response assessment, and prognosis. Diagnostic and staging challenges persist due to variable imaging features in TNBC and limitations in conventional modalities, increasing the risk of delayed detection. Predicting response to neoadjuvant systemic therapy remains difficult, as patient responses are heterogeneous, and existing clinical markers provide limited early predictive value. Prognostication in TNBC is similarly constrained …

Comparison Of Deep Learning Schemes In Grading Non-Alcoholic Fatty Liver Disease Using B-Mode Ultrasound Hepatorenal Window Images With Liver Biopsy As The Gold Standard, Petros Drazinos, Ilias Gatos, Paraskevi F Katsakiori, Stavros Tsantis, Efstratios Syrmas, Stavros Spiliopoulos, Dimitris Karnabatidis, Ioannis Theotokas, Pavlos Zoumpoulis, John D Hazle, George C Kagadis

Faculty, Staff and Student Publications

Background/introduction: To evaluate the performance of pre-trained deep learning schemes (DLS) in hepatic steatosis (HS) grading of Non-Alcoholic Fatty Liver Disease (NAFLD) patients, using as input B-mode US images containing right kidney (RK) cortex and liver parenchyma (LP) areas indicated by an expert radiologist.

Methods: A total of 112 consecutively enrolled, biopsy-validated NAFLD patients underwent a regular abdominal B-mode US examination. For each patient, a radiologist obtained a B-mode US image containing RK cortex and LP and marked a point between the RK and LP, around which a window was automatically cropped. The cropped image dataset was augmented using up-sampling, …

Three-Dimensional Deep Learning Normal Tissue Complication Probability Model To Predict Late Xerostomia In Patients With Head And Neck Cancer, Hung Chu, Suzanne P M De Vette, Hendrike Neh, Nanna M Sijtsema, Roel J H M Steenbakkers, Amy Moreno, Johannes A Langendijk, Peter M A Van Ooijen, Clifton D Fuller, Lisanne V Van Dijk

Faculty, Staff and Student Publications

Purpose: Conventional normal tissue complication probability (NTCP) models for patients with head and neck cancer are typically based on single-value variables, which, for radiation-induced xerostomia, are baseline xerostomia and mean salivary gland doses. This study aimed to improve the prediction of late xerostomia by using 3-dimensional information from radiation dose distributions, computed tomography imaging, organ-at-risk segmentations, and clinical variables with deep learning (DL).

Methods and materials: An international cohort of 1208 patients with head and neck cancer from 2 institutes was used to train and twice validate DL models (deep convolutional neural network, EfficientNet-v2, and ResNet) with 3-dimensional dose distribution, …

Overview Of The Ciciot2023 Dataset For Internet Of Things Intrusion Detection Systems, Wisam Ali Hussein Salman, Chan Huah Yong

Mesopotamian Journal of Big Data

The rapid expansion of the use of the Internet of Things (IoT) has encouraged many attackers to exploit the vulnerabilities in these networks to violate data privacy or disrupt service; they are easy targets due to the diversity of devices within the network, which has led to the loss of unified security standards. intrusion detection system (IDS) play a pivotal role in securing IoT networks by monitoring inbound and outbound traffic to these networks and issuing a security alarm when there is an attack; moreover, they respond directly to these security threats to prevent them from harming the network and …

Ai-Driven Smart Contract Vulnerability Detection: A Systematic Review Of Methods, Challenges, And Future Prospects, Saad Al Azzam, Raenu Al Kolandaisamy, Ghassan Al Dharhani

Mesopotamian Journal of Big Data

Smart contracts (SCs) have become an essential component in the world of decentralized applications, automating transactions across blockchain networks without the need for intermediaries, and with this rise in adoption, the technology has also brought forth growing concern due to security vulnerabilities, which have led to serious financial damage, and the problem is far from being solved. Traditional auditing methods often struggle to capture the more intricate vulnerabilities hidden within smart contract logic, particularly owing to the irreversible nature of blockchain transactions. Given these challenges, researchers have been actively exploring more advanced detection techniques. Despite progress, many existing studies tend …

A Deep Learning Approach For Identifying Malicious Activities In The Industrial Internet Of Things, Mohammed Amin Almaiah, Fuad Ali El-Qirem, Rami Shehab, Khaled Sulieman Momani

Mesopotamian Journal of Computer Science

Data-driven decision-making, real-time connectivity, and automation have transformed industrial operations with the Industrial Internet of Things. However, the integration also introduces substantial cybersecurity vulnerabilities, making IIoT networks a prime target for malicious activities. Cyber threats are evolving and becoming more sophisticated, which makes traditional security mechanisms inadequate. An approach using deep learning to detect malicious activities in IIoT environments is examined. It is investigated whether Deep Feed Forward neural networks, autoencoders, and convolutional neural networks are effective at detecting anomalies and mitigating cyber threats. NSL-KDD and UNSW-NB15 benchmark datasets are used to evaluate the proposed model's accuracy, precision, and detection …

Self-Attention Enhanced Dual Bigru For Arabic Fake News Detection, Baqer M. Merzah, Jafar Razmara, Jaber Karimpour

Mesopotamian Journal of Computer Science

The rapid proliferation of social media platforms has greatly amplified the dissemination of fake news, representing significant obstacles to public trust and evidence-based decision-making, particularly for the Arabic-speaking population. Meeting the challenge of Arabic fake news detection is a problem compounded by the complex morphological nature of the language, as well as limited resources. This study presents a hybrid deep learning framework that integrates two Bidirectional Gated Recurrent Units (BiGRUs) along with an attention mechanism for efficiently detecting misinformation in Arabic news. The method leverages FastText word embeddings for disambiguating the intricate semantics of the Arabic language. The model is …

Delineating Underground Geological Formations: An Integrated Lidar And Camera-Based Approach For Enhanced Feature Identification In Poorly Lit Mining Environments, Timothy James Batchler

Graduate Theses, Dissertations, and Problem Reports (ETD)

Underground mining environments present challenges in accurately identifying geological formations and potential hazards due to poor lighting conditions and confined spaces. Traditional imaging methods often fall short, making it difficult to detect critical geological features such as limestone, shale, and other rock formations. This research addresses these challenges by integrating camera imagery with Light Detection and Ranging (LiDAR) data to improve geological formation detection in poorly lit mining settings.

LiDAR, with its ability to generate high-resolution three-dimensional models in low-light or dark conditions, offers a promising solution to these limitations. By combining LiDAR’s precise 3D models with camera imagery, the …

The Representation Of Feminine Beauty In Generative Artificial Intelligence Models, Haley R. Stacy

Murray State Theses and Dissertations

As Artificial Intelligence (AI) technology advances, its influence on media and societal perceptions becomes increasingly significant. This dissertation explores how popular generative visual AI models represent women and the implications for racial and body type inclusivity. This study examines women’s perceptions of AI-generated representations. Two primary research questions are being explored: (1) How do AI-generated algorithms represent women in visual outputs when prompted with broad beauty-related keywords? (2) How do women perceive their representation in these AI-generated visual outputs? Through a detailed analysis of AI-generated imagery, the research uncovers implicit and explicit biases within these systems. The research also gathered …

Leveraging Deep Learning Models And Social Media Data For Enhanced Situation Awareness In Disaster Management, Ademola Abdulganiyu Adesokan

Doctoral Dissertations

"In recent years, social media has become a crucial source of real-time data for disaster management, supporting emergency responses when traditional channels like 911 are overcrowded and overwhelmed. It offers authorities valuable data for developing effective strategies, especially when swift actions are essential to save lives. However, the informal language, ambiguous meanings, and irrelevant content on social media pose challenges to accurate classification and hinder the efficient extraction of disaster-relevant information, leading to inefficiencies in emergency response efforts.

This research focuses on seven key questions: i) How can we detect, classify, and analyze hate and offensive tweet emotions during large-scale …

Time Series Forecasting With Lstm: An Extensive Content Analysis, Andri Pranolo, Xiaofeng Zhou, Yingchi Mao

Knowledge Engineering and Data Science

This paper presents a comprehensive bibliometric and content review of the trend, architecture, and application of long short-term memory (LSTM) models for time series forecasting. The study aims to provide insights into the overall statistics and distribution of papers focused on LSTM for forecasting. Additionally, the research questions address the most highly cited papers based on LSTM approaches in forecasting, the most productive journals in this field, and identifying trends, gaps, summary tasks and their performance, datasets availability, and future research directions for LSTM in forecasting. This paper is a comprehensive review of LSTM for forecasting from 2017 to 2023 …

Deep Learning For Uav Classification: Impact Of Noise And Multipath Fading In Rf Signals, Prajoy Podder, Maciej Jan Zawodniok, Sanjay Kumar Madria

Electrical and Computer Engineering Faculty Research & Creative Works

The increasing presence of unmanned aerial vehicles (UAVs) raises serious security concerns, particularly regarding unauthorized drone operations. Recent U.S. security statistics report a sharp rise in unauthorized UAV activities, with the Federal Aviation Administration (FAA) receiving over 100 monthly reports of illegal drone operations near airports. In 2024 alone, Dedrone records 1.19 million unauthorized drone flights across major U.S. cities, highlighting the need for robust UAV detection and classification systems. In this work, a lightweight Convolutional Neural Network (CNN) model is proposed for RF-based UAV classification under noisy and multipath fading conditions. The proposed CNN consists of multiple convolutional blocks, …

Leveraging Artificial Intelligent For Optimized Crop Production: An Ann-Based Approach, Yahya Layth Khaleel, Fadya A. Habeeb, Mustafa Abdulfattah Habeeb, Fatimah N. Ameen

Mesopotamian Journal of Computer Science

To incite modern day crop production and ensure sustainability, exact crop recommendations are key to the process. This study pays significant attention to the need for the use of big data tools in studies involving comprehensive data sets that contain information on soil and other environmental characteristics. The set of data used in this research includes Nitrogen, Phosphorus, and Potassium content coordinated with Temperature, Humidity, pH Value, and Rainfall. Knowing these factors is to make a favorable decision about improving agricultural products yield, availability and management of the resources, as well as general well-being of the crops. Specialized advisory on …

Enhancing Cybersecurity In Smart Education With Deep Learning And Computer Vision: A Survey, Guma Ali, Aziku Samuel, Maad M. Mijwil, Kholoud Al-Mahzoum, Malik Sallam, Ioannis Adamopoulos, Ayodeji Olalekan Salau, Indu Bala, Klodian Dhoska, Engin Melekoglu

Mesopotamian Journal of Computer Science

The rapid digital transformation of education, driven by the widespread adoption of smart devices and online platforms, has ushered in the era of smart education. While this shift enhances learning experiences, it also introduces significant cybersecurity risks that threaten the confidentiality, integrity, and availability of educational resources, student data, and institutional systems. This survey examines how deep learning (DL) and computer vision (CV) techniques can enhance cybersecurity in smart education environments. By reviewing 202 peer-reviewed research papers published between January 2022 and June 2025 across leading publishers such as ACM Digital Library, Frontiers, Wiley Online Library, IGI Global, Nature, Springer, …

Haze-Image-Dataset: A Large-Scale Benchmark For Image Dehazing In Variable Fog And Low-Light Conditions, Mustafa J. Shahbaz, Ali A.D. Al-Zuky

Mesopotamian Journal of Computer Science

To enhance image dehazing and visual recognition in real-world conditions, we introduce HAZE-IMAGE-DATASET, a large-scale dataset comprising nearly 42,000 images. It is constructed from 1,532 clean images sourced globally and captured using a Samsung smartphone, covering diverse natural and urban scenes. The dataset includes synthetic and real haze variations. Synthetic haze was generated using MATLAB-based atmospheric scattering models with depth maps for 10 fog levels. Colored haze was created using alpha blending (α = 0.4) in six colors: red, green, blue, yellow, white, and black. Low-light conditions were simulated via uniform darkening at 10 levels. Also, 616 real haze images …

Generalizing Medical Image Segmentation Task With Efficient Deep Learning Models, Abel A. Reyes-Angulo

Dissertations, Master's Theses and Master's Reports

Medical Image Segmentation is a critical task in the field of medical imaging, playing a crucial role in diagnostics, treatment planning, and disease monitoring. The emergence of Deep Learning (DL) has ushered in a new era in Artificial Intelligence (AI), propelling remarkable advancements in key domains like language translation, object recognition, and recommendation systems. This evolution has been accompanied by continuous enhancements in computational efficiency and improvements in predictive accuracy. The introduction of sophisticated algorithms, such as convolutional neural networks (CNNs) and transformers, exemplifies these advancements. DL algorithms have demonstrated exceptional efficacy in medical image segmentation tasks, showcasing the potential …

Application Of Artificial Intelligence Techniques To Improve Leadership Decision Making With Uncertainty, Michael David Parrish

Doctoral Dissertations

"Every good leader is a good manager, but not every good manager is a good leader. The difference between the leader and the manager is critical decision-making. Today’s decision-making environment is characterized as Volatile, Uncertain, Complex, and Ambiguous (VUCA). With the exponential increase in the technical capabilities of systems, the human has become the weakest link in the use of such systems. To remain relevant, good leaders must continuously adapt to new advances in technology and processes.

The research contributions of this work provide several unique and novel solutions for leaders to utilize artificial intelligence tools to improve and optimize …

Deep Learning And Adaptive Clustering Approaches For Flood Prediction And Efficient Sensor Placement In Missouri, Fahimeh Sharafkhani

Doctoral Dissertations

Floods represent formidable natural calamities, posing a significant threat to communities and infrastructure due to their unpredictable and often devastating consequences. The occurrence of floods is influenced by a convergence of meteorological, hydrological, and geographical factors, resulting in changes to the patterns of rising water levels. Machine learning models have emerged as favored tools in recent times for modeling water levels and enhancing the precision of flood predictions. This research employs both supervised and unsupervised machine learning models, with the main objective of improving the accuracy of flood predictions and sensor placement. Four distinct deep learning models are used to …

Deep Learning Architecture Design For Nano-Satellite Image Super-Resolution, William Everette Symolon

Doctoral Dissertations

Increasing threats to U.S. national security satellite constellations have resulted in an increased interest in constellation resilience and satellite redundancy. NanoSats have contributed to commercial, scientific and government applications in remote sensing, communications, navigation, and research. They also have the potential to enhance satellite constellation resilience. However, the inherent size, weight, and power limitations of NanoSats enforce constraints on imaging hardware; the small lenses and short focal lengths result in imagery with low spatial resolution, which limits the utility of CubeSat images for military planning purposes and national intelligence applications. This research proposed a deep learning architecture capable of enhancing …

Assessing The Cardioprotective Effects Of Exercise In Apoe Mouse Models Using Deep Learning And Photon-Counting Micro-Ct, Alex J Allphin, Rohan Nadkarni, Zay Y Han, Darin P Clark, Ketan B Ghaghada, Alexandra Badea, Cristian T Badea

Faculty, Staff and Students Publications

Background: The allelic variations of the apolipoprotein E (APOE) gene play a critical role in regulating lipid metabolism and significantly impact cardiovascular disease risk (CVD). This study aimed to evaluate the impact of exercise on cardiac structure and function in mouse models expressing different APOE genotypes using photon-counting computed tomography (PCCT) and deep learning-based segmentation.

Methods: A total of 140 mice were grouped based on APOE genotype (APOE2, APOE3, APOE4), sex, and exercise regimen. All mice were maintained on a controlled diet to isolate the effects of exercise. Low dose cardiac photon counting micro-CT imaging with intrinsic gating was performed …

Enhancing Image Classification Using A Convolutional Neural Network Model, Zena M. Saadi, Ahmed T. Sadiq, Omar Z. Akif, Marwa M. Eid

Journal of Soft Computing and Computer Applications

In recent years, with the rapid development of the current classification system in digital content identification, automatic classification of images has become the most challenging task in the field of computer vision. As can be seen, vision is quite challenging for a system to automatically understand and analyze images, as compared to the vision of humans. Some research papers have been done to address the issue in the low-level current classification system, but the output was restricted only to basic image features. However, similarly, the approaches fail to accurately classify images. For the results expected in this field, such as …

Quantifying Interpretation Reproducibility In Vision Transformer Models With Tavac., Yue Zhao, Dylan Agyemang, Yang Liu, J Matthew Mahoney, Sheng Li

Faculty Research 2024

Deep learning algorithms can extract meaningful diagnostic features from biomedical images, promising improved patient care in digital pathology. Vision Transformer (ViT) models capture long-range spatial relationships and offer robust prediction power and better interpretability for image classification tasks than convolutional neural network models. However, limited annotated biomedical imaging datasets can cause ViT models to overfit, leading to false predictions due to random noise. To address this, we introduce Training Attention and Validation Attention Consistency (TAVAC), a metric for evaluating ViT model overfitting and quantifying interpretation reproducibility. By comparing high-attention regions between training and testing, we tested TAVAC on four public …

Modelling V-Band Atmospheric Loss With Deep Learning, Ralph Lyndon Gesner

Electrical and Computer Engineering ETDs

Modelling atmospheric loss is fundamental to implementation of future mm-wave terrestrial and earth space communication links. Atmospheric losses have traditionally been estimated by calculating the contributions of individual weather phenomena through in-situ meteorological measurements and statistically derived models for estimating localized atmospheric water content. Collecting data for all points along the propagation path and calculating the physical effects of gases, clouds, and precipitation individually is both time consuming and impractical for large-scale use cases.

In response to these present limitations, this work proposes the use of novel deep learning models for estimating atmospheric losses from tabular meteorological sensor data and …

Real-Time Feedback-Driven Framework For Automated Cybersickness Mitigation, Md Jahirul Islam

Master's Theses

As technologies are becoming more advanced day by day, the embracement of virtual reality (VR) technology among users is also increasing in daily activities for various purposes, and subsequently, the barrier between the real and virtual world is fading. Despite the versatile uses, cybersickness (CS) is a major problem which is induced among users due to the immersive VR experience. There is a plethora of research findings and methods to measure the users’ CS such as virtual reality sickness questionnaire (VRSQ), simulator sickness questionnaire (SSQ), fast motion scale questionnaire (FMS), and others. Recently, machine learning approaches have also been adopted …

Identifying Subject Bias In Wifi-Based Human Activity Recognition Evaluation Methods, Amany Elkelany, Robert J. Ross, Susan Mckeever

Conference papers

WiFi-based Human Activity Recognition (HAR) has emerged as a promising approach for monitoring and analysing human activities in a non-intrusive manner, leveraging WiFi signals for activity classification. Despite advancements, existing WiFi-based HAR research lacks consideration of subject (human) bias. This results in learning models performing well on individuals used in the training samples but failing to generalise to new/unseen subjects, in contrast to known good practices in machine learning. In this paper, we address this oversight directly by systematically examining the evaluation methodology for the WiFi-based HAR context. Specifically, we investigate the impact of Leave-One-Subject-Out Cross-Validation (LOSOCV) in a hybrid …

Automated Segmentation Of Mri White Matter Hyperintensities In 8421 Patients With Acute Ischemic Stroke, Hosung Kim, Wi-Sun Ryu, Dawid Schellingerhout, Jonghyeok Park, Jinyong Chung, Sang-Wuk Jeong, Dong-Seok Gwak, Beom Joon Kim, Joon-Tae Kim, Keun-Sik Hong, Kyung Bok Lee, Tai Hwan Park, Jong-Moo Park, Kyusik Kang, Yong-Jin Cho, Byung-Chul Lee, Kyung-Ho Yu, Mi Sun Oh, Soo Joo Lee, Jae-Kwan Cha, Dae-Hyun Kim, Jun Lee, Man Seok Park, Hee-Joon Bae, Dong-Eog Kim

Faculty, Staff and Student Publications

Background and purpose: To date, only a few small studies have attempted deep learning-based automatic segmentation of white matter hyperintensity (WMH) lesions in patients with cerebral infarction; this issue is complicated because stroke-related lesions can obscure WMH borders. We developed and validated deep learning algorithms to segment WMH lesions accurately in patients with cerebral infarction using multisite data sets involving 8421 patients with acute ischemic stroke.

Materials and methods: We included 8421 patients with stroke from 9 centers in Korea. 2D UNet and squeeze-and-excitation (SE)-UNet models were trained using 2408 FLAIR MRIs from 3 hospitals and validated using 6013 FLAIR …

A Machine Learning Approach For Estimating Evapotranspiration For Urban Landscaping Vegetation In Semi-Arid Regions, Damian Lorenzo Gallegos Espinoza

Open Access Theses & Dissertations

Water management is important for residents in semi-arid urban areas due to increasing demand, water scarcity, and rising costs. It is estimated that in semi-arid regions, 40-70% of the household water consumption is used in landscaping. Therefore, urban landscaping water use can substantially contribute to water conservation. This work aims to estimate the water needs of urban landscaping vegetation to inform residents in semi-arid regions.Evapotranspiration indicates water and energy exchange between the atmosphere, soil, and vegetation. This interaction depends on solar radiation, evaporation, transpiration, and other biophysical parameters. Evapotranspiration has become a reference for water management in agriculture (e.g., crop …

Physics-Informed Deep Learning For Pilot Parameter Estimation And Pilot-Induced Oscillation Characterization, Stephen A. Brutch

Doctoral Dissertations and Master's Theses

This thesis investigates the issue of loss-of-control in flight which is a driving contributor to fatal aviation accidents. The two main contributors tackled in this research are human pilot error and categories of pilot-induced-oscillations. The primary objective is to develop models that can capture the mathematical parameters that relate to human pilot control under the widely used McRuer Mathematical pilot model. The goal is that if the mathematical parameters that relate to human pilot control can be monitored during flight then the pilot’s input to the control system and pilot-induced-oscillations (PIO) can be monitored during flight to avoid loss-of-control. This …

Cmos-Based Rotational Spectroscopy: Massive Spectral Fingerprint Generation And Molecular Detection With Deep Learning, Yasamin Fozouni

Computer Science and Engineering Theses and Dissertations

Rotational Spectroscopy is a powerful spectral fingerprinting approach that can be used for identifying different gas molecules in a sample. Gas molecules are free to rotate, with inertia, in fixed states of quantized energy. In Rotational Spectroscopy, radiative beams are shown onto a sample to cause an energy-based transition between quantized rotational states. By sweeping the frequency of the radiative beams and monitoring the absorption with a sensor, one can profile the different rotational states, monitoring for energy based transitions. These transitions are dependent on unique properties of the molecules, thus presenting a unique molecular identification fingerprint (in the form …