Digital Commons Network^™

Preventing Sudden Cardiac Death In Athletes: In Search Of Evidence-Based, Cost-Effective Screening, Paolo Angelini, Mladen I Vidovich, Christine E Lawless, Macarthur A Elayda, J Alberto Lopez, Dwayne Wolf, James T Willerson

The Texas Heart Institute Journal

Sudden cardiac death in athletes is a recurrent phenomenon at sporting events and during training. Recent studies have associated sudden cardiac death with such cardiovascular conditions as coronary artery anomalies, cardiomyopathies, and electrocardiographic abnormalities, most of which are screenable with modern imaging techniques. We recently inaugurated the Center for Coronary Artery Anomalies at the Texas Heart Institute, which is dedicated to preventing sudden cardiac death in the young and investigating coronary artery anomalies. There, we are conducting 2 cross-sectional studies intended to firmly establish and quantify, in a large group of individuals from a general population, risk factors for sudden …

Micronutrient Fortification Of Food And Its Impact On Woman And Child Health: A Systematic Review, Jai K. Das, Rehana A. Salam, Rohail Kumar, Zulfiqar A. Bhutta

Department of Paediatrics and Child Health

Background: Vitamins and minerals are essential for growth and metabolism. The World Health Organization estimates that more than 2 billion people are deficient in key vitamins and minerals. Groups most vulnerable to these micronutrient deficiencies are pregnant and lactating women and young children, given their increased demands. Food fortification is one of the strategies that has been used safely and effectively to prevent vitamin and mineral deficiencies.
Methods: A comprehensive search was done to identify all available evidence for the impact of fortification interventions. Studies were included if food was fortified with a single, dual or multiple micronutrients and impact …

Influence Of Body Mass Index And Antibiotic Dose On The Risk Of Surgical Site Infections In Pediatric Clean Orthopedic Surgery., Jeffrey J Cies, Shannon Chan, Jobayer Hossain, B Randall Brenn, M Cecilia Di Pentima

Department of Anesthesiology Faculty Papers

OBJECTIVE: To evaluate body mass index (BMI) and antimicrobial dose as risk factors for surgical site infections in pediatric patients.

PATIENTS AND METHODS: Children between 2 and 19 years of age undergoing clean orthopedic procedures and receiving at least one dose of perioperative antibiotics (cefazolin, vancomycin, or clindamycin) were studied. The retrospective case-controlled study was conducted at the Alfred I. duPont Hospital for Children, a 180-bed tertiary-care academic pediatric hospital in Wilmington, DE. Data were collected from January 1, 2002, to December 31, 2005.

RESULTS: Underweight children had a higher risk for SSIs than overweight and normal-weight children. American Society …

Medical Evidence In Cases Of Intrauterine Drug And Alcohol Exposure , Judith Larsen, Robert M. Horowitz, Ira J. Chasnoff

Pepperdine Law Review

No abstract provided.

Pediatric Pharmacogenomics: A Systematic Assessment Of Ontogeny And Genetic Variation To Guide The Design Of Statin Studies In Children., Jonathan B. Wagner, J Steven Leeder

Manuscripts, Articles, Book Chapters and Other Papers

The dose-exposure-response relationship for drugs may differ in pediatric patients compared with adults. Many clinical studies have established drug dose-exposure relationships across the pediatric age spectrum; however, genetic variation was seldom included. This article applies a systematic approach to determine the relative contribution of development and genetic variation on drug disposition and response using HMG-CoA reductase inhibitors as a model. Application of the approach drives the collection of information relevant to understanding the potential contribution of ontogeny and genetic variation to statin dose-exposure-response in children, and identifies important knowledge deficits to be addressed through the design of future studies.

Rice Consumption And Urinary Arsenic Concentrations In U.S. Children, Matthew A. Davis, Todd A. Mackenzie, Kathryn L. Cottingham, Diane Gilbert-Diamond, Tracy Punshon, Margaret R. Karagas

Dartmouth Scholarship

Background: In adult populations, emerging evidence indicates that humans are exposed to arsenic by ingestion of contaminated foods such as rice, grains, and juice; yet little is known about arsenic exposure among children.

Objectives: Our goal was to determine whether rice consumption contributes to arsenic exposure in U.S. children.

Methods: We used data from the nationally representative National Health and Nutrition Examination Survey (NHANES) to examine the relationship between rice consumption (measured in 0.25 cups of cooked rice per day) over a 24-hr period and subsequent urinary arsenic concentration among the 2,323 children (6–17 years of age) who participated in …

25(Oh)D3 And Cardiovascular Risk Factors In Female Nonhuman Primates., Matthew J Jorgensen, Lawrence L Rudel, Matthew Nudy, Jay R Kaplan, Thomas B Clarkson, Nicholas M Pajewski, Peter F Schnatz

Division of Internal Medicine Faculty Papers & Presentations

OBJECTIVE: To determine if interindividual differences in plasma concentrations of 25-hydroxyvitamin D(3) (25(OH)D(3)) have pathophysiologic significance, we evaluated a cohort of female monkeys, seeking to identify associations with clinically relevant cardiovascular risk factors, including age, abdominal obesity (waist circumference), and high-density lipoprotein cholesterol (HDL-C).

METHODS: One hundred fifty-five female vervet monkeys (Chlorocebus aethiops sabaeus) aged 3-25 years consumed a typical western diet for 7-8 weeks that provided a woman's equivalent of approximately 1000 IU/day of vitamin D(3). Measurements of vitamin D(3) and HDL-C concentrations, as well as waist circumference, were obtained.

RESULTS: Among young monkeys (aged 3-5 years), compared to …

Plant Calcium Content: Ready To Remodel, Jian Yang, Tracy Punshon, Mary Lou Guerinot, Kendal D. Hirschi

Dartmouth Scholarship

By identifying the relationship between calcium location in the plant cell and nutrient bioavailability, the plant characteristics leading to maximal calcium absorption by humans can be identified. Knowledge of plant cellular and molecular targets controlling calcium location in plants is emerging. These insights should allow for better strategies for increasing the nutritional content of foods. In particular, the use of preparation-free elemental imaging technologies such as synchrotron X-ray fluorescence (SXRF) microscopy in plant biology may allow researchers to understand the relationship between subcellular location and nutrient bioavailability. These approaches may lead to better strategies for altering the location of calcium …

School Day Segmented Physical Activity Patterns Of High And Low Active Children, Stuart J. Fairclough, Aaron Beighle, Heather Erwin, Nicola D. Ridgers

Kinesiology and Health Promotion Faculty Publications

BACKGROUND: Variability exists in children's activity patterns due to the association with environmental, social, demographic, and inter-individual factors. This study described accelerometer assessed physical activity patterns of high and low active children during segmented school week days whilst controlling for potential correlates.

METHODS: Two hundred and twenty-three children (mean age: 10.7 ± 0.3 yrs, 55.6% girls, 18.9% overweight/obese) from 8 north-west England primary schools wore ActiGraph GT1M accelerometers for 7 consecutive days during autumn of 2009. ActiGraph counts were converted to minutes of moderate (MPA), vigorous (VPA) and moderate-to-vigorous (MVPA) physical activity. Children were classified as high active (HIGH) or …

Oncolog, Volume 57, Number 02, February 2012, Don Norwood, Bryan Tutt

OncoLog MD Anderson's Report to Physicians (All issues) Archives

• Pediatric and Adult Cancer Patients Face Different Issues in Care, Survivorship: The challenges faced by children and adults with cancer can differ markedly, even when they have the same type of cancer
• Palliative Care May Offer Survival Benefits: Recent studies indicate that palliative care, which has been shown to improve quality of life in patients with advanced cancer, may also help patients live longer
• INBRIEF: Targeted Therapy Causes Chronic Lymphocytic Leukemia Remission/Study Finds Acupuncture Can Prevent Radiation-Induced Chronic Dry Mouth
• HOUSE CALL: Understanding the risks, benefits, and purpose of a trial can help cancer patients decide whether to participate

Seeds Of Hope : Improving The Nutritional Environment Of Seaside Middle School, Emily Abrahams

Capstone Projects and Master's Theses

Schools play a crucial role in the development of children. One way schools can be utilized is by positively influencing the eating habits of students. Poor diet has caused many detrimental effects within our society. In order to address the issue of poor nutritional environments in schools, Harvest of the Month (HOTM), a nutritional program provided through Community Alliance with Family Farmers (CAFF), was implemented in a 6th grade class as a pilot program. The program then expanded to 3 more 6th grade classes. Along with implementing the HOTM program, steps to begin a fruit tree orchard were also taken. …

Malaria And Related Outcomes In Patients With Intestinal Helminths: A Cross-Sectional Study, Abraham Degarege, Mengistu Legesse, Girmay Medhin, Abebe Animut, Berhanu Erko

Journal Articles: Epidemiology

BACKGROUND: The effects of helminth co-infection on malaria in humans remain uncertain. This study aimed to evaluate the nature of association of intestinal helminths with prevalence and clinical outcomes of Plasmodium infection.

METHODS: A cross-sectional study involving 1,065 malaria suspected febrile patients was conducted at Dore Bafeno Health Center, Southern Ethiopia, from December 2010 to February 2011. Plasmodium and intestinal helminth infections were diagnosed using Giemsa-stained blood films and Kato-Katz technique, respectively. Haemoglobin level was determined using a haemocue machine.

RESULTS: Among 1,065 malaria suspected febrile patients, 28.8% were positive for Plasmodium parasites (P. falciparum =13.0%, P. vivax =14.5%, P. …

Sensory Processing In Children With Adhd: A Classroom Study And Rational Item Analysis, Jason Mathison

PCOM Psychology Dissertations

In the classroom, distinguishing between sensory modulation disorder (SMD), one proposed subtype of Sensory Processing Disorder, and attention deficit hyperactivity disorder (ADHD) can be difficult given their similar behavioral manifestations. The overlap between these two disorders and the prevelance of rating scales used for gathering diagnostic information warrant a closer look at items on commonly used rating scales to ensure discriminative validity. This pilot study examined specific patterns of SMD in 24 children with ADHD using the Sensory Profile School Companion (SPSC), which includes four components of SMD, namely, Seeking, Avoiding, Registration, and Sensitivity. As hypothesized, the majority of teacher …

Oral Findings In Children With Celiac Disease, Vi̇ldan Erteki̇n, Muhammed Aki̇f Sümbüllü, Mahya Sultan Tosun, Mukadder Ayşe Seli̇moğlu, Mustafa Kara, Ni̇hat Kiliç

Turkish Journal of Medical Sciences

Aim: To investigate whether Turkish children with celiac disease (CD) show dental enamel defects (DEDs), recurrent aphthous stomatitis (RAS), teeth missing, and xerostomia, and to compare the results with age- and sex-matched healthy children. Materials and methods: The oral cavity was explored in 81 patients with CD (mean age 8.7 ± 3.7 years; age range 2.5 to 17 years) and in 20 healthy controls. Enamel defects, teeth missing, RAS, and xerostomia were established. Results: Forty-three (53.1%) celiac patients and 5 (25%) control subjects had enamel defects. Enamel defects occurred more frequently in patients (P = 0.025) compared to controls. Regarding …

Effects Of Early Intervention Services On Adaptive Functioning, Osslyn Sam

PCOM Psychology Dissertations

In 1986, Congress enacted Public Law 99-457, Part H of the Individuals with Disabilities Education Act (IDEA). This law, currently referred to as Part C, was established in response to the growing number of children born with developmental delays. Infants born prematurely, addicted to drugs, or with conditions such as Down Syndrome face challenging lives. Part C allows for eligible infants, ages birth to three years to receive free early intervention services to address their individual delays. Previous studies have shown that children who have participated in early intervention programs have benefited in various areas of their overall development. The …

An Occupational Therapy-Based Education Program For Caregivers Of Individuals With Cerebral Palsy: A Culturally Conscious Perspective, Allison L. Kalb, Diana L. Huettl

Occupational Therapy Capstones

Introduction: Individuals with cerebral palsy (CP) are able to lead functional, productive, and fulfilling lives when provided the opportunity. In the country of Ghana, the prevalence of CP is estimated to be one out of every 300 births (Purple Field Productions [PFP], 2011), however, a lack of education about CP and other disabilities, limited access to healthcare services, and scarce resources hamper the Ghanaian people’s opportunities for habilitation (Reynolds, 2010; Tinney, Chiodo, Haig, & Wiredu, 2007). In addition, cultural beliefs and societal attitudes toward people with disabilities in Ghana pose a barrier for those individuals to fully participate in occupation. …

Maternal Work Hours In Early To Middle Childhood Link To Later Adolescent Diet Quality, Jianghong Li, Therese O'Sullivan, Sarah Johnson, Fiona Stanley, Wendy H. Oddy

Research outputs 2012

Objective: Previous studies on maternal work hours and child diet quality have reported conflicting findings possibly due to differences in study design, lack of a comprehensive measure of diet quality and differing ages of the children under investigation. The present study aimed to prospectively examine the impact of parental work hours from age 1 year to age 14 years on adolescent diet quality.

Design: Multivariate linear regression models were used to examine independent associations between parents' work hours at each follow-up and across 14 years and adolescent diet quality at age 14 years. A diet quality index was based on …

Parent-Led Activity And Nutrition (Plan) For Healthy Living: Design And Methods, William T. Dalton, Karen E. Schetzina, Nicole Holt, Hazel Fulton-Robinson, Ai-Leng Ho, Fred Tudiver, Mathew T. Mcbee, Tiejian Wu

ETSU Faculty Works

Child obesity has become an important public health concern, especially in rural areas. Primary care providers are well positioned to intervene with children and their parents, but encounter many barriers to addressing child overweight and obesity. This paper describes the design and methods of a cluster-randomized controlled trial to evaluate a parent-mediated approach utilizing physician's brief motivational interviewing and parent group sessions to treat child (ages 5–11 years) overweight and obesity in the primary care setting in Southern Appalachia. Specific aims of this pilot project will be 1) to establish a primary care based and parent-mediated childhood overweight intervention program …

Atypical Clinical And Diagnostic Features In Ménétrier's Disease In A Child, Michael Chung, Jaime Pittenger, Deborah Flomenhoft, Jeffrey Bennett, Eun Young Lee, Harohalli Shashidhar

Internal Medicine Faculty Publications

Ménétrier's disease is one of the rarest protein-losing gastropathies in childhood. It is characterized clinically by non-specific gastrointestinal symptoms and edema, biochemically by hypoalbuminemia, and pathologically by enlarged gastric folds. In adults, this disease can be devastating with significant morbidity and mortality. In childhood, it is a self-limiting, transient and benign illness. Its treatment is largely supportive with total parenteral nutrition (TPN) while oral intake is encouraged. Acute onset of vomiting in healthy school age children can be initially explained by acute viral gastroenteritis. However, persistent vomiting associated with hematemesis and severe abdominal pain should warrant further work-up. This case …

Youth Physical Activity Opportunities In Lower And Higher Income Neighborhoods, Richard Suminski, Ding Ding, Rebecca Lee, Linda E. May, Tonya Tota, David Dinius

Faculty and Staff Publications

The presence of youth physical activity opportunities is one of the strongest environmental correlates of youth physical activity. More detailed information about such opportunities is needed to maximize their contributions to physical activity promotion especially in under resourced, lower income areas. The objectives of this study were to construct a comprehensive profile of youth physical activity opportunities and contrast profile characteristics between lower and higher income neighborhoods. Youth physical activity opportunities in eight lower (median household income <$36,000) and eight higher (>$36,000) income neighborhoods were identified and described using interviews, neighborhood tours, site visits, and systematic searches of various sources (e.g., Internet). Lower income …

Identification Of Factors Associated With Good Response To Growth Hormone Therapy In Children With Short Stature: Results From The Answer Program®., Peter A Lee, John Germak, Robert Gut, Naum Khutoryansky, Judith Ross

Department of Pediatrics Faculty Papers

UNLABELLED: ABSTRACT:

OBJECTIVE: To identify factors associated with growth in children on growth hormone (GH) therapy using data from the American Norditropin Studies: Web-enabled Research (ANSWER) Program® registry.

METHODS: GH-naïve children with GH deficiency, multiple pituitary hormone deficiency, idiopathic short stature, Turner syndrome, or a history of small for gestational age were eligible (N = 1,002). Using a longitudinal statistical approach, predictive factors were identified in patients with GHD for change from baseline in height standard deviation score (ΔHSDS) following 2 years of treatment.

RESULTS: Gradual increases in ΔHSDS over time were observed for all diagnostic categories. Significant predictive factors …

Prevalensi Dan Determinan Kelebihan Berat Badan Dan Kegemukan Pada Anak Berusia 5-15 Tahun, Ratu Ayu Dewi Sartika

Kesmas

Kelebihan berat badan dan kegemukan, suatu keadaan lemak tubuh yang berlebihan, merupakan masalah kesehatan di negara-negara maju dan negara-negara berkembang, termasuk Indonesia. Penelitian ini bertujuan untuk mengetahui prevalensi dan determinan kelebihan berat badan dan kegemukan anak usia 5-15 tahun menggunakan data Riset Kesehatan Dasar (Riskesdas) tahun 2007. Ditemukan bahwa prevalensi kelebihan berat badan dan kegemukan pada anak berusia usia 5-15 tahun masing-masing 7,4% dan 8,3%. Jika dikontrol oleh jenis kelamin, tingkat pendidikan, riwayat kegemukan ibu, kebiasaan konsumsi buah mingguan, kebiasaan merokok, dan asupan energi, faktor paling dominan yang berhubungan dengan kelebihan berat badan (> 85% persentil) anak adalah riwayat kegemukan …

Emotional Climate, Feeding Practices, And Feeding Styles: An Observational Analysis Of The Dinner Meal In Head Start Families, Sheryl O Hughes, Thomas G Power, Maria A Papaioannou, Matthew B Cross, Theresa A Nicklas, Sharon K Hall, Richard M Shewchuk

Faculty, Staff and Students Publications

BACKGROUND: A number of studies conducted with ethnically diverse, low-income samples have found that parents with indulgent feeding styles had children with a higher weight status. Indulgent parents are those who are responsive to their child's emotional states but have problems setting appropriate boundaries with their child. Because the processes through which styles impact child weight are poorly understood, the aim of this study was to observe differences in the emotional climate created by parents (including affect, tone of voice, and gestures) and behavioral feeding practices among those reporting different feeding styles on the Caregiver's Feeding Styles Questionnaire. A secondary …

An Evaluation Of The Emerging Interventions Against Respiratory Syncytial Virus (Rsv)-Associated Acute Lower Respiratory Infections In Children, Harish Nair, Vasundhara R. Verma, Evropi Theodoratou, Lina Zgaga, Tanvir Huda, Eric Af Simoes, Peter F. Wright, Igor Rudan, Harry Campbell

Dartmouth Scholarship

Background: Respiratory Syncytial Virus (RSV) is the leading cause of acute lower respiratory infections (ALRI) in children. It is estimated to cause approximately 33.8 million new episodes of ALRI in children annually, 96% of these occurring in developing countries. It is also estimated to result in about 53,000 to 199,000 deaths annually in young children. Currently there are several vaccine and immunoprophylaxis candidates against RSV in the developmental phase targeting active and passive immunization.

Methods: We used a modified CHNRI methodology for setting priorities in health research investments. This was done in two stages. In Stage I, we systematically reviewed …

Weight-Control Practices Reported By Students In A Maine Middle School, Alan Maijka

Journal of Extension

Extension professionals who work with youth are often faced with issues of body weight, diet and/or body image. How we handle these topics has the potential to either help or harm. The goal of the study reported here was to explore the prevalence and types of weight-control methods practiced by middle school students. The majority of students reported practices that have been previously associated with increased risk for becoming overweight. Those who work with children should be careful to avoid contributing to the tendency for children to begin weight-control practices that may paradoxically increase their risk for becoming overweight.

White Potatoes, Including French Fries, Contribute Shortfall Nutrients To Children's And Adolescents' Diets, Marjorie Freedman, Debra Keast

Faculty Publications

To test the hypothesis that white potatoes (WP), oven-baked fries (OBF), and french fries (FF) contribute important nutrients within energy needs to children's and adolescents' diets, secondary analysis of 24-hour dietary recall data from the National Health and Nutrition Examination Survey 2003-2006 was conducted. Potato content of survey foods was determined using US Department of Agriculture recipe databases (Standard Reference (SR)-Link files). Nutrient content of potatoes was determined by linking SR codes to US Department of Agriculture food composition data. Daily nutrient intakes from potatoes were determined by applying the composition database to respondent's recall data. Sample-weighted data were analyzed; …

Asthma Control In Oman : National Results Within The Asthma Insights And Reality In The Gulf & The Near East (Airgne) Study, Nasser Al-Busaidi, Joan B. Soriano

Sultan Qaboos University Medical Journal

Objectives: The Asthma Insights and Reality (AIR) study in the Gulf and Near East (one of a worldwide series of surveys conducted in adults and children to assess asthma control) was conducted in Oman to assess how closely asthma control meets international guidelines recommendations. Methods: From January 2007 to March 2008, asthmatics receiving treatment or currently suffering from asthma symptoms were interviewed among nationals randomly surveyed from the most populated urban areas in Oman (Muscat, Sohar and Nizwa). The standard AIR questionnaire was used to assess symptom severity, health care utilisation, limitation of activity and medication use. Results: From 201 …

Children With Gastroesophageal Reflux Disease: A Guide To Therapeutic And Pharmacological Treatments, Rebecca Mcomie

Occupational Therapy Capstones

Gastroesophageal reflux disease (GERD) is becoming a more common diagnosis with young children and babies (PAGER, 2010). GERD is often misdiagnosed and there is no single test available to determine its presence (Eisen, 2001). The term reflux can be confusing and used to mean different things to different people. Often reflux is linked to colic in babies or may be considered a "normal" part of being a baby. But when a sequalae of symptoms arise in an infant, gastroesophageal reflux becomes a serious issue that needs to be addressed through a variety of interventions and sources (Sondheimer, 2006 ).

In …

A Qualitative Analysis Of Homeless Women With Children In Transitional Housing: What Are Their Needs?, Urmi B. Jani

PCOM Psychology Dissertations

In 2004, the National Law Center on Homelessness and Poverty indicated that approximately 3.5 million people experienced homelessness. The literature indicates that families, specifically female-headed ones, are the fastest growing segment of the homeless population. The development of transitional housing has shown promise by seeking to move these homeless families towards independent living. A qualitative study based in grounded theory was utilized to explore the experiences of 10 female homeless participants at two regional transitional living facilities. Consistent themes that emerged included dissolution of relationships and a lack of personal supports as being the primary pathways that lead to homelessness. …

Obesity In Children And Adolescents And Its Relationship With Hypertension, Dr Vijayanath Itagi, Ramesh Patil

Turkish Journal of Medical Sciences

It is difficult to project the prevalence of obesity and overweight among children in India since there is no nationally representative data from India. We determined the time trends in childhood obesity in a representative sample of schoolchildren from Raichur District, Karnataka and investigated the relationship of obesity with blood pressure. Materials and methods: We used a stratified random cluster sampling method to select the children. Anthropometric data were collected from 23,842 students, 5-16 years of age, during 2005-06. Blood pressure and anthropometric data were collected from 19,263 students during 2007-08. Overweight and obesity were defined by body mass index …