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Ccr5 Inhibition In Critical Covid-19 Patients Decreases Inflammatory Cytokines, Increases Cd8 T-Cells, And Decreases Sars-Cov2 Rna In Plasma By Day 14, Bruce K Patterson, Philip A Mudd, Et Al

Open Access Publications

OBJECTIVE: Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is now a global pandemic. Emerging results indicate a dysregulated immune response. Given the role of CCR5 in immune cell migration and inflammation, we investigated the impact of CCR5 blockade via the CCR5-specific antibody leronlimab on clinical, immunological, and virological parameters in severe COVID-19 patients.

METHODS: In March 2020, 10 terminally ill, critical COVID-19 patients received two doses of leronlimab via individual emergency use indication. We analyzed changes in clinical presentation, immune cell populations, inflammation, as well as SARS-CoV-2 plasma viremia before and 14 days after treatment.

RESULTS: Over the …

Black & African American Veteran Entrepreneurs: February 2021, Rosalinda V. Maury, Mirza Tihic, Najla Almissalati

Institute for Veterans and Military Families

This brief provides highlights from the 2020 National Survey of Military-Affiliated Entrepreneurs study focusing on Black and African American veteran entrepreneurs. These findings are based on the data collected from 333 Black and African American veteran entrepreneurs, which represents 21% of the respondents that answered the race/ethnicity question of the 2020 survey. This study monitors trends in the activity, needs, and economic, social, and policy barriers of military-affiliated entrepreneurs in the United States.

Focal St-Segment Elevation Without Coronary Occlusion: Myocardial Infarction With No Obstructive Coronary Atherosclerosis Associated With Covid-19-A Case Report, Casey Meizinger, Bruce D. Klugherz

Division of Cardiology Faculty Papers

Background: While it is understood that coronavirus disease 2019 (COVID-19) is primarily complicated by respiratory failure, more data are emerging on the cardiovascular complications of this disease. A subset of COVID-19 patients present with ST-elevations on electrocardiogram (ECG) yet normal coronary angiography, a presentation that can fit criteria for myocardial infarction with no obstructive coronary atherosclerosis (MINOCA). There is little known about non-coronary myocardial injury observed in patients with COVID-19, and we present a case that should encourage further conversation and study of this clinical challenge.

Case summary: An 86-year-old man presented to our institution with acute hypoxic respiratory failure …

Acute Respiratory Distress Syndrome, George W Williams, Nathaniel K Berg, Alexander Reskallah, Xiaoyi Yuan, Holger K Eltzschig

Faculty, Staff and Student Publications

Acute Respiratory Distress Syndrome (ARDS) is defined as the rapid onset of non-cardiogenic pulmonary edema resulting in respiratory failure and hypoxemia. Efforts over the past 25 years, such as those of the ARDS and Prevention and Early Treatment of Acute Lung Injury (PETAL) Networks, have demonstrated a praiseworthy collaboration to further optimize the management of ARDS. However, improvements have been only moderate and ARDS remains a leading cause of mortality in the perioperative and critical care setting. Recently, the significant morbidity and mortality of ARDS have been emphasized by its high incidence in Coronavirus Disease 2019 (COVID-19) patients. A major …

The George-Anne Daily, Georgia Southern University

George-Anne Media Group: Newsletters & Magazines

No abstract provided.

Student Well-Being In The Time Of Covid: Survey Of Online Students’ Coping, Ellen Catherine Coble

Theses and Dissertations

The emergence of the COVID-19 pandemic has presented the global population with a considerable stressor resulting in significant loss of life, impaired health, disrupted social practices, and economic atrophy. While many have been impacted and are currently being studied, a population less frequently considered in the literature is that of online college students. Previous research has indicated the influence of several factors on college students’ well-being when coping with stress under typical circumstances such as coping strategies (e.g., problem-focused, emotion-focused, and avoidant/dysfunctional), experiential avoidance, and social support. Studies performed in the wake of large-scale crises highlight proximity to the crisis …

Education Of Infectious Diseases Fellows During The Covid-19 Pandemic Crisis: Challenges And Opportunities, Lisa M Chirch, Wendy S Armstrong, Gayle P Balba, Prathit A Kulkarni, Constance A Benson, Victoria Konold, Vera P Luther, Obinna N Nnedu, Sarah Perloff, Raymund R Razonable, Wendy Stead, George R Thompson, Michael T Melia

Faculty, Staff and Students Publications

One of the many challenges that has befallen the Infectious Diseases and Graduate Medical Education communities during the coronavirus disease 2019 (COVID-19) pandemic is the maintenance of continued effective education and training of the future leaders of our field. With the remarkable speed and innovation that has characterized the responses to this pandemic, educators everywhere have adapted existing robust and safe learning environments to meet the needs of our learners. This paper will review distinct aspects of education and training of the Infectious Diseases fellows we believe the COVID-19 pandemic has impacted most, including mentoring, didactics, and wellness. We anticipate …

From Surviving To Thriving: Effective Ministry And Evangelism In The Covid-19 Era And Beyond, S. Joseph Kidder, Willie Edward Hucks Ii

Faculty Publications

No abstract provided.

Covid-19 Infection Outcome In African American Renal Transplant Recipients: Detroit Medical Center, Claudia Jarrin Tejada Md, Mareena Zachariah Md, Angela Cruz Md, Shakir Hussein Md, Elizabeth Wilpula Pharmd, Nicole Meeks, Jeffrey A. Wolff Msn, Agacnp-Bc, Pranatharthi Chandrasekar Md

Medical Student Research Symposium

Background: Transplant recipients are more vulnerable to infections including COVID-19, given their comorbidities and chronic immunosuppression. Most preliminary care series report rapid clinical progression and higher mortality compared to the general population.

Methods: Retrospective study at Harper University Hospital - Detroit Medical Center. Twenty-five renal transplant recipients (RTR) presenting consecutively with COVID-19 symptoms and positive NP swab PCR for SARS-CoV2 between 03/01/2020 - 05/01/2020 were included. Data on demographics, clinical presentation, laboratory findings, management and outcomes were collected.

Results: Patients had a median age of 56, all African American and deceased donor transplant recipients. Most had hypertension …

Elevated Liver Enzymes Portends A Higher Rate Of Complications And Death In Acute Respiratory Syndrome Coronavirus 2 (Sars-Cov-2), Emily E. Currier, Mohamed Dabaja Do, Syed-Mohammed Jafri Md

Medical Student Research Symposium

Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), or COVID-19, has infected millions worldwide since its discovery in December 2019, but little is still known about the disease process. Preliminary research in China notes liver function test (LFTs) abnormalities are common in COVID-19 patients, suggesting decreased hepatic function, and that abnormalities in LFTs are related to complicated disease course and negative outcomes. However, there has been limited large-scale data assessing COVID-19’s association with liver dysfunction and negative outcomes.

Aim: The significance of this research is to investigate how COVID-19 affects the liver function and disease course in patients infected with …

30-Day Mortality And Cardiopulmonary Complication Rates In Patients Undergoing Emergency Surgery With Perioperative Sars-Cov-2 Infection, Akshay Sood Md, Nicholas Corsi, Mohit Butaney Md, Jacob Keeley Ms, Chandler Bronkema, Ziad Affas Md, Guillaume Farah, Michael Chien, Renee Hanna, Stephen Wertheimer, Steven Chang Md, Amarnath Rambhatla Md, Hans Stricker Md, James Peabody Md, Mani Menon Md, Craig Rogers Md, Nikola Rakic, Firas Abdollah Md

Medical Student Research Symposium

INTRODUCTION AND OBJECTIVE: Continued vigilance of operative outcomes in COVID-19 patients is important given the relative novelty of the SARS-CoV-2 infection. We sought to evaluate the 30-day mortality and cardiopulmonary complication rates in patients undergoing emergency surgery with perioperative COVID-19, in comparison to a control group of medically managed COVID-19 patients that did not require a surgical intervention.

METHODS: A retrospective chart review at a single tertiary-care hospital in Michigan was undertaken. Patients who had tested positive for SARS-CoV-2 infection either 7 days before or within 30 days after surgery during March-May 2020 were included in the study (n=52). Propensity …

Complication Rates In Resident Cataract Surgery After Elective Operating Room Shutdown During The Covid-19 Pandemic, Michael Schneider, Christian Mehregan Md, Collin Richards, Shibandri Das Md, Xihui Lin Md

Medical Student Research Symposium

Purpose: To assess the types of cataract surgeries being performed at one large eye institute from before and after the COVID-19 induced shutdown of elective surgeries in Spring 2020.

Methods: This is a retrospective chart review study of operative reports from resident performed cataract surgeries from January 1st, 2020 through July 31st, 2020. Cataract surgeries were categorized into Pre-COVID (Jan – Mar 2020) if they occurred prior to operating room (OR) shutdown on March 18th, 2020 and Post COVID for all cases which occurred after the shutdown orders were lifted (May – July 2020). A resident survey was also used …

Healthcare Protection Policies During The Covid-19 Pandemic: Lessons Towards The Implementation Of The New Egyptian Universal Health Insurance Law, Alaa Ghannam, Ayman Sebae

Faculty Journal Articles

On March 11th 2020, the World Health Organization (WHO) declared the coronavirus a global pandemic. The spread of the virus in many countries has exceeded the capabilities of the traditional healthcare systems and has challenged government plans to contain it.

The COVID-19 pandemic arrived in Egypt at a time when the first steps in the implementation of the newly ratified law on social health insurance were taking place. Law number 2 for the year 2018 saw the first steps of its implementation in Port Said governorate. As the realisation of the law is proceeding in other governorates, the pandemic and …

After Covid-19: Mitigating Domestic Gender-Based Violence In Egypt In Times Of Emergency, Diana Magdy, Hind Ahmed Zaki

Faculty Journal Articles

In times of crises and emergencies, violence against women tends to increase. The outbreak of COVID-19 has resulted in severe precautionary measures such as social isolation, physical distancing, staying at home, curfews and lockdowns, which brought “normal” life to a halt and created a temporary convergence between the public and the private. The pandemic has forced the global community to turn its gaze back to the private, and compelled them to pay attention to the old/new problem of gender-based violence, particularly, domestic violence that spiked during the pandemic. Against such a backdrop, and using a critical feminist lens that analyzes …

2021-01-31_Michiganoverview_Covidsymptoms, Michigan Department Of Health & Human Services

Michigan COVID-19 Syndromic Surveillance System Data

The Syndromic Surveillance System Data report was obtained from Michigan's COVID-19 dashboard, from under the link "​Coronavirus Symptoms": https://www.michigan.gov/coronavirus. Data was compiled by the Michigan Department of Health and Human Services (MDHHS). The information was updated daily.

Syndromic Surveillance System data is obtained from approximately 183 facilities participating in syndromic surveillance (132 Emergency Departments (ED), 51 Urgent Cares) across the State of Michigan. The reporting is based on individuals who present at EDs and may not be representative of the overall population. The coronavirus-like symptoms query searches visit free-text (chief complaint, triage notes, and clinical impression) for fever or …

The Role Of Technology (Social Media) In Increasing The Awareness Of Healthy Life Styles And Strengthening Social Interactions: An Effort To Handle Covid-19 In The Micro Environment, Eko Wijayanto

International Review of Humanities Studies

The COVID-19 pandemic has changed the interaction patterns and culture of society. The pretext of limiting interactions as the key to handle COVID-19 certainly has various challenges in its implementation in society. Regulators have promulgated various global and national policies (in macro level). It is necessary to ascertain whether the policy can be conveyed and implemented correctly at the micro-level in the community, which has various social and cultural characters. Neighborhood Association (known as Rukun Warga in Indonesia), as the smallest community in society, is undoubtedly the spearhead in ensuring all global and national policies can be carried out correctly. …

Employment Security In Egypt In Light Of The Covid-19 Pandemic: Rethinking Policies And Practices, Heba M. Khalil, Kareem Megahed

Faculty Journal Articles

Crises such as COVID-19’s have inequitable impacts on different countries, various population groups and diverse sectors of society and the economy. Areas of work and employment were met with a lot of challenges worldwide, and in particular in countries like Egypt with a large sector of vulnerable and precarious workers. This policy paper addresses the question of employment security both in response to crises such as COVID-19, and on the long term. To do so, the research maps ‘vulnerable work’, including informal labor, labor in the gig economy, self-employed and other types of precarious work. It then assesses Egypt’s policy …

Executive Summary- Social Protection In Egypt: Mitigating The Socio-Economic Effects Of The Covid-19 Pandemic On Vulnerable Employment, Dina Makram-Ebeid, Amr Adly, Nadine Sika, Hania M Sholkamy, Samer Atallah

Faculty Journal Articles

This is the executive summary of an interdisciplinary project between the fields of development economics, political economy, labor sociology, development anthropology and public health. It reviews the social protection available to vulnerable employees and their households in Egypt and suggests ways to adapt them in light of the COVID 19 pandemic. The research focuses on four areas a) employment security b) social assistance c) health insurance d) gendered mitigations. The project will map the impact of the crisis on vulnerable employees and their households and propose policy interventions to alleviate the socio-economic effects of the pandemic through the publication of …

The Immediate And Long-Term Effects Of Covid-19 Stay-At-Home Orders On Domestic Violence Calls For Service Across Six U.S. Jurisdictions, Justin Nix, Tara N. Richards

Criminology and Criminal Justice Faculty Publications

We assessed immediate and long-term trends in calls for police service regarding domestic violence following COVID-19 stay-at-home orders. Using open data from the Police Data Initiative, we performed interrupted time-series analyses of weekly calls for service for domestic violence in New Orleans (LA), Cincinnati (OH), Seattle (WA), Salt Lake City (UT), Montgomery County (MD), and Phoenix (AZ). Results indicate that five of the six jurisdictions experienced an immediate, significant spike in domestic violence calls for service (Cincinnati being the lone exception). As stay-at-home orders were lifted throughout the remainder of 2020, domestic violence calls for service declined in every jurisdiction …

On Mainstreaming Social Thinking In Macroeconomic Policies, Amira Othman, Hania Sholkamy, Chahir Zaki

Faculty Journal Articles

This paper questions the degree to which social thinking is guiding social policy in Egypt. The apparent fluctuations in social spending coupled with the lack of clear purpose and benchmarks for social programs attest to a conceptual and political compromise whereby the social is at the mercy of non-social considerations. The evidence that supports our main contention is derived from an analysis that poses and answers two seminal questions: first, to what extent social policies are mainstreamed in the design of macroeconomic policies and integrated in economic and development cycles; second, to what extent the Ministry of Finance can sustain …

Rediscovering Archaeology Using The Cultural Heritage Of Serang City, Banten Province For Community Recovery During Covid-19 Pandemic, Ali Akbar

International Review of Humanities Studies

Many archaeological researches have been conducted in Serang City, Banten Province for decades so that a significant amount of knowledge has been produced. The Public Archaeology approach, especially museums and cultural resource management, has also been applied. However, these efforts have not been maximized resulting in several problems. Particularly, since 2020, COVID-19 pandemic has affected various fields and sectors, including the cultural sectors related to the preservation and management of cultural heritage in Serang City. The efforts to prevent the transmission of COVID-19 have been carried out by implementing health protocols and large-scale social restriction policies including on the sites …

Prevalence Of Functional Limitation In Covid-19 Recovered Patients Using The Post Covid-19 Functional Status Scale, Pankaj Pant, Aishana Joshi, Babin Basnet, Bibek Man Shrestha, Navindra Raj Bista, Niraj Bam, Santa Kumar Das

Faculty, Staff and Student Publications

INTRODUCTION: COVID-19 is an emerging global health pandemic causing tremendous morbidity and mortality worldwide. Chronic symptoms progressing to poor functional status have been reported in a substantial proportion of COVID-19 patients worldwide. This study aimed to determine the prevalence of functional limitation in COVID-19 recovered patients using the post-COVID-19 functional status scale.

METHODS: A descriptive cross-sectional study was conducted at Tribhuvan University Teaching Hospital. COVID-19 recovered patients with reverse transcription-polymerase chain reaction negative status were included and assessed using the post-COVID-19 functional status scale. Data entry and analysis was done in Statistical Package for the Social Sciences version 20.0. Descriptive …

The News Effect Of Covid-19 On Global Financial Market Volatility, Anasuya Haldar, Narayan Sethi

Bulletin of Monetary Economics and Banking

This study investigates whether the coronavirus (COVID-19) pandemic caused a contagion and negatively affected the stock market. Using data from the 10 worst-hit countries over the period from December 2019 to May 2020 and an EGARCH model, the study shows that market speculations lead to negative stock returns and higher stock market volatility. Further, estimates of both bivariate time-series regression and random-effects panel regression show significant effects of COVID-19 related media coverage on the stock market.

Impact Of Covid-19 On Islamic And Conventional Stocks In Indonesia: A Wavelet-Based Study, Mohsin Ali, Urooj Anwar, Muhammad Haseeb

Bulletin of Monetary Economics and Banking

The recent literature shows that COVID-19 has impacted stock markets around the world in many ways. In this paper, we examine the reaction of the Indonesian stock market to COVID-19. We apply the continuous wavelet coherence methodology to daily COVID-19 related deaths and daily conventional and Islamic stock indices inIndonesia. We find that COVID-19 negatively impacts the returns of both indices and enhances their volatility. We find the Islamic stock index to be more volatile as compared to its conventional counterpart during the COVID-19 outbreak.

The Covid-19 Pandemic And Indian Pharmaceutical Companies: An Event Study Analysis, Chinmaya Behera, Badri Narayan Rath

Bulletin of Monetary Economics and Banking

Although there is a plethora of studies which examine the impact of the COVID-19 pandemic on India’s financial sector, we contribute by investigating the effect of the ongoing COVID-19 pandemic on stock returns of Indian pharmaceutical companies. By employing an event study methodology, our results indicate that the average returns of the pharmaceutical sector are positive during the COVID-19 phase although mixed evidence is found at the firm level. This finding is also robust to alternative model specifications.

Impact Of Covid-19 On A Free Clinic Patient Population, Mitchell Naveh Bs, Tanha Shah Ms, Shravan Morisetty Bs, Amanda Fisher Bs, Alisha Pandit Ba, Tasnim Rahman Bs, Kenan Alhayek Bs, Arthur Orchanian Bs, Andrea Janis Bs, Meredith Hengy Bs, Avinash Ramkissoon Mph, Ralph Williams Ii Md, Dionyssios Tsilimingras Md

Medical Student Research Symposium

The Robert R. Frank Student Run Free Clinic at WSUSOM, surveyed patients to determine the impact of the COVID-19 pandemic on its patient population. The study examined any challenges faced in food, financial status, transportation, and healthcare. A Qualtrics survey was administered with ethnicity, age, and gender as controls, while testing patient responses to social factors using the Likert scale. The survey was targeted to a portion of the clinic’s patient pool (n=33) over a span of three months and responses were analyzed using SPSS 26 regression analysis, ANOVA, and paired sample T-tests. Significant responses were across demographics, categories of …

2021-01-30_Michiganoverview_Covidsymptoms, Michigan Department Of Health & Human Services

Michigan COVID-19 Syndromic Surveillance System Data

The Syndromic Surveillance System Data report was obtained from Michigan's COVID-19 dashboard, from under the link "​Coronavirus Symptoms": https://www.michigan.gov/coronavirus. Data was compiled by the Michigan Department of Health and Human Services (MDHHS). The information was updated daily.

Syndromic Surveillance System data is obtained from approximately 183 facilities participating in syndromic surveillance (132 Emergency Departments (ED), 51 Urgent Cares) across the State of Michigan. The reporting is based on individuals who present at EDs and may not be representative of the overall population. The coronavirus-like symptoms query searches visit free-text (chief complaint, triage notes, and clinical impression) for fever or …

2021-01-30_Michigandaily_Covidmap, Michigan Department Of Health & Human Services

Daily Michigan COVID-19 Update

The "WHERE WE STAND WITH COVID-19" map was obtained from Michigan's main COVID-19 page: https://www.michigan.gov/coronavirus. Data was compiled by the Michigan Department of Health and Human Services (MDHHS). The information was updated daily at 3p.m., Monday - Saturday.

The State of Michigan is working around the clock to test and treat COVID-19 patients. Below is the most recent data healthcare experts across the state have compiled.

The image contained a map, indicating total cases by county, and also provides statistics on Total Confirmed Cases, Total COVID-19 Deaths, Daily Confirmed Cases, and Daily COVID-19 Deaths. There …

2021-01-30_Michiganoverview_Covidstats, Michigan Department Of Health & Human Services

Cumulative Michigan COVID-19 Data

The COVID Overview page was obtained from Michigan's main COVID-19 page: https:/www.michigan.gov/coronavirus/0,9753,7-406-98163-520743--,00.html.

The State of Michigan is working around the clock to test and treat COVID-19 patients. Below is the most recent data healthcare experts across the state have compiled. It is updated Monday - Saturday.
This report is provisional and subject to change. City of Detroit and Wayne County are reported separately. MDHHS began tracking probable cases April 5, 2020. FCI indicates federal correctional institute. MDOC indicates Michigan Department of Corrections. Diagnostic tests, including nucleic acid amplification/real-time polymerase chain reaction (NAAT/RT-PCR) and rapid virus antigen detection point of …

Confronting The Covid-19 Pandemic: A View From The Laboratory, Gary W. Procop

Marshall Journal of Medicine

A retrospective review of salient features of the early-to-mid phases COVID-19 pandemic is provided from the perspective of the clinical laboratory. Lessons learned and possible improvements are opined. These include the importance of maintaining a robust laboratory infrastructure, increased public health funding, the partnership between public health and hospital/commercial laboratories, and the critical importance of sound scientific assessment even during a pandemic crisis.