Digital Commons Network^™

Gold & Blue, Summer/Fall 2021, St. Mary's University- San Antonio, Texas

Gold & Blue

This is the Summer/Fall 2021 edition of Gold & Blue which is St. Mary's University's official school publication.

Data-Driven Clustering Identifies Features Distinguishing Multisystem Inflammatory Syndrome From Acute Covid-19 In Children And Adolescents., Alon Geva, Manish M. Patel, Margaret M. Newhams, Cameron C. Young, Mary Beth F. Son, Michele Kong, Aline B. Maddux, Mark W. Hall, Becky J. Riggs, Aalok R. Singh, John S. Giuliano, Charlotte V. Hobbs, Laura L. Loftis, Gwenn E. Mclaughlin, Stephanie P. Schwartz, Jennifer E. Schuster, Christopher J. Babbitt, Natasha B. Halasa, Shira J. Gertz, Sule Doymaz, Janet R. Hume, Tamara T. Bradford, Katherine Irby, Christopher L. Carroll, John K. Mcguire, Keiko M. Tarquinio, Courtney M. Rowan, Elizabeth H. Mack, Natalie Z. Cvijanovich, Julie C. Fitzgerald, Philip C. Spinella, Mary A. Staat, Katharine N. Clouser, Vijaya L. Soma, Heda Dapul, Mia Maamari, Cindy Bowens, Kevin M. Havlin, Peter M. Mourani, Sabrina M. Heidemann, Steven M. Horwitz, Leora R. Feldstein, Mark W. Tenforde, Jane W. Newburger, Kenneth D. Mandl, Adrienne G. Randolph, Overcoming Covid-19 Investigators

Manuscripts, Articles, Book Chapters and Other Papers

Background: Multisystem inflammatory syndrome in children (MIS-C) consensus criteria were designed for maximal sensitivity and therefore capture patients with acute COVID-19 pneumonia.

Methods: We performed unsupervised clustering on data from 1,526 patients (684 labeled MIS-C by clinicians)clusters, followed by recursive feature elimination to identify characteristics of potentially misclassified MIS-C-labeled patients.

Findings: Of 94 clinical features tested, 46 were retained for clustering. Cluster 1 patients (N = 498; 92% labeled MIS-C) were mostly previously healthy (71%), with mean age 7·2 ± 0·4 years, predominant cardiovascular (77%) and/or mucocutaneous (82%) involvement, high inflammatory biomarkers, and mostly SARS-CoV-2 PCR negative (60%). Cluster …

Developing An Innovative Pandemic Treaty To Advance Global Health Security, Lawrence O. Gostin, Benjamin Mason Meier, Barbara Stocking

Georgetown Law Faculty Publications and Other Works

Recognizing marked limitations of global health law in the COVID-19 pandemic, a rising number of states are supporting the development of a new pandemic treaty. This prospective treaty has the potential to clarify state obligations for pandemic preparedness and response and strengthen World Health Organization authorities to promote global health security. Examining the essential scope and content of a pandemic treaty, this column analyzes the policymaking processes and substantive authorities necessary to meet this historic moment.

Relative Risk Of Anxiety And Depression Among Covid-19 Survivor Healthcare Workers From A Tertiary Care Hospital In Pakistan: A Pilot Cohort Study, Farnaz Zahoor, Zahid Nazar, Sarwat Masud, Rehana Rahim

Department of Emergency Medicine

Longitudinal studies for determining the risk of anxiety and depression among COVID-19 survivor healthcare workers are lacking. This study aimed to determine the risk of anxiety and depression among healthcare workers that survived COVID-19 infection through a six-month post-recovery follow-up. This was a cohort study conducted at the Department of Obstetrics and Gynecology, Lady Reading Hospital, Peshawar, from 1st March to 30th August 2020. A total of 64 subjects participated. Hospital Anxiety and Depression Scale (HADS) was used for assessing the anxiety and depression symptoms. HADS has three score cutoff as normal, borderline abnormal and, abnormal anxiety/depression. For the purpose …

Examining Media Dependency And Parasocial Relationship On Protective Action Behaviors During Covid-19, Amy Hyman

Dissertations

The COVID-19 pandemic illuminated the significant role that mass media plays in disseminating messages to the public during disasters and public health crises. Information disseminated during a disaster influences individuals’ decision-making process regarding protective actions, or mitigation behaviors. This study examined the relationship between media dependency theory, parasocial relationship, and media effects (cognitive, affective and behavioral) during the COVID-19 pandemic. A quantitative approach was used with a convenience sample. The sample focused on residents in the state of Arkansas and specific generational cohorts. The results found that the generational cohorts had different media preferences during the height of …

Who Gets To Make A Living? Street Vending In America, Joseph Pileri

Scholarly Articles in Law Reviews & Journals

Street vending has long provided those at the margins of American society with the opportunity for economic advancement. A key segment of the informal economy, street vending has low barriers of entry and attracts entrepreneurs who lack the resources, ability, or desire to start brick-and-mortar businesses or work for someone else. Street vending also contributes to the vitality and safety of urban America.

Despite the pivotal role that street vending plays, cities around the country criminalize vending by treating the violation of street vending regulations as a criminal offense. Recent high-profile vendor arrests in New York City and Washington, DC …

High-Throughput Next-Generation Sequencing Respiratory Viral Panel: A Diagnostic And Epidemiologic Tool For Sars-Cov-2 And Other Viruses, Nikhil S. Sahajpal, Ashis K. Mondal, Allan Njau, Zachary Petty, Jiani Chen, Sudha Ananth, Pankaj Ahluwalia, Colin Williams, Ted M. Ross, Alka Chaubey

Pathology, East Africa

Two serious public health challenges have emerged in the current COVID-19 pandemic namely, deficits in SARS-CoV-2 variant monitoring and neglect of other co-circulating respiratory viruses. Additionally, accurate assessment of the evolution, extent, and dynamics of the outbreak is required to understand the transmission of the virus. To address these challenges, we evaluated 533 samples using a high-throughput next-generation sequencing (NGS) respiratory viral panel (RVP) that includes 40 viral pathogens. The performance metrics revealed a PPA, NPA, and accuracy of 95.98%, 85.96%, and 94.4%, respectively. The clade for pangolin lineage B that contains certain distant variants, including P4715L in ORF1ab, Q57H …

Cognitive Barriers To Covid-19 Vaccine Uptake Among Older Adults, Jonathan L. Chia, Andree Hartanto

Research Collection School of Social Sciences

The COVID-19 pandemic has resulted in tremendous loss of life. As of late-July 2021, there have been more than 191 million confirmed cases and over 4.1 million deaths recorded (1). Although most nations have developed some competency in COVID-19 containment (2–4), there are new challenges. The continual spread of COVID-19 has resulted in new variants (5–7). These new variants are posited to have a significantly higher transmissibility (8–10), with higher fatality rates (11, 12).

Peer Leading Small Group Discussion During Covid-19, A. E. Dreyfuss, Ana Fraiman, Milka O. Montes, Reagan Hudson, Fernando Montalvillo Ortega, Jonathan Muniz, Franziska Piefke, Mikayla Rodriguez, Meinar Sheila, Keyshla Vargas, Nicky Vu

Publications and Research

Peer-led workshops in General Chemistry at the University of Texas Permian Basin (UTPB) were affected by COVID-19 restrictions during the 2020-2021 academic year. Most Peer-Led Team Learning (PLTL) workshops were conducted in person, but with the difference that protocols of distancing had to be observed, and a few were conducted online, so adjustments were necessary to prepare Peer Leaders to conduct their workshops in both types of settings. The facets of the modified PLTL program were supported by the online preparation for facilitation and chemistry content.

The results of an examination of critical incidents are shared here. This qualitative examination …

The Impact Of The Covid-19 Pandemic On People With Rheumatic And Musculoskeletal Diseases: Insights From Patient-Generated Data On Social Media, Katja Reuter, Atul Deodhar, Souzi Makri, Michael Zimmer, Francis Berenbaum, Elena Nikiphorou

Computer Science Faculty Research and Publications

Objectives

During the COVID-19 pandemic, much communication occurred online, through social media. This study aimed to provide patient perspective data on how the COVID-19 pandemic impacted people with rheumatic and musculoskeletal diseases (RMDs), using Twitter-based patient-generated health data (PGHD).

Methods

A convenience sample of Twitter messages in English posted by people with RMDs was extracted between 1 March and 12 July 2020 and examined using thematic analysis. Included were Twitter messages that mentioned keywords and hashtags related to both COVID-19 (or SARS-CoV-2) and select RMDs. The RMDs monitored included inflammatory-driven (joint) conditions (ankylosing spondylitis, RA, PsA, lupus/SLE and gout).

Results …

The Rapid Assessment Of Aggregated Wastewater Samples For Genomic Surveillance Of Sars-Cov-2 On A City-Wide Scale., Eric C. Rouchka, Julia H. Chariker, Kumar Saurabh, Sabine Waigel, Wolfgang Zacharias, Mei Zhang, Daymond Talley, Ian Santisteban, Madeline Puccio, Sarah Moyer, Rochelle H. Holm, Ray A. Yeager, Kevin J. Sokoloski, Joshua Fuqua, Aruni Bhatnagar, Ted Smith

Faculty and Staff Scholarship

Throughout the course of the ongoing SARS-CoV-2 pandemic there has been a need for approaches that enable rapid monitoring of public health using an unbiased and minimally invasive means. A major way this has been accomplished is through the regular assessment of wastewater samples by qRT-PCR to detect the prevalence of viral nucleic acid with respect to time and location. Further expansion of SARS-CoV-2 wastewater monitoring efforts to include the detection of variants of interest/concern through next-generation sequencing has enhanced the understanding of the SARS-CoV-2 outbreak. In this report, we detail the results of a collaborative effort between public health …

Trauma-Informed Supports For Rebuilding School Communities, Nancy S. Stockall, William H. Blackwell

Journal of Human Services: Training, Research, and Practice

This manuscript describes four principles of trauma-informed supports that can guide school leaders in rebuilding school communities that have been fractured by the COVID-19 pandemic. Based on the work of Hobfoll et al. (2007), these principles are: a) promoting a sense of safety, b) addressing safety within behavior support practices, c) building relationships, and d) promoting self-efficacy and instilling hope. As schools slowly reopen, there is a risk that the re-opening will signify that the crisis has ended and schools can return to their previous policies and systems of support. However, the lingering and long-term effects of the isolation and …

Crisis Preparedness In Acute And Intensive Treatment Settings: Lessons Learned From A Year Of Covid-19, Jarrod M Leffler, Cassandra L Esposito, Elisabeth A Frazier, Michelle A Patriquin, Meredith K Reiman, Alysha D Thompson, Carl Waitz

Staff and Researcher Publications

The impact of COVID-19 changed the use and delivery of health care services, requiring an abrupt shift in treatment and staffing models 1,2. This is particularly salient in youth acute and intensive treatment services (AITS), including inpatient psychiatric hospitals (IPH), intensive outpatient programs (IOP), and partial hospitalization programs (PHP), because of challenging issues of maintaining high-quality care and a safe therapeutic milieu during increased demand for acute services,3 all while limiting transmission of COVID-19 on locked units, in close quarters, and for youths traveling back and forth to day-programs. Over the past year, AITS adapted and evolved without the ability …

Environmental Protection And Human Rights In The Pandemic, Maria Antonia Tigre, Sarah C. Slinger, James R. May

Scholarly Works

The Covid-19 outbreak in 2020 took the world by surprise. The virus spread quickly around the globe and death tolls were constantly on the rise at early stages of the pandemic. Although vaccine rollouts have helped halt the number of deaths, inequality in accessing vaccines and effective treatments is still a major issue. From the onset, Covid-19 negatively impacted global well-being and myriad human rights. The present report examines how environmental protection and related human rights have been affected by the Covid-19 pandemic. Based on link between environmental and human health, this report focuses on ecological human rights. The report …

Is Regional Mobility Control Effective In Minimising Covid-19 Spread? Lessons Learned From Jakarta’S Large-Scale Social Restriction, Fisca Rizkiani Azmi, Bevaola Kusumasari

BISNIS & BIROKRASI: Jurnal Ilmu Administrasi dan Organisasi

In times of crisis such as a pandemic, local governments serve a pivotal role as first-hand responders in managing emergencies in local areas, with the expectation of an effective policy to implement. Notwithstanding, there are limited literature studies of emergency management on local governments, concentrating on identifying policy effectiveness by the implementation in the field. This article emphasizes the effectiveness of local policy implementation in managing the emergency of the COVID-19 pandemic in the Jakarta area, with the centralization on Large-Scale Social Restriction as the case study. The objective is to provide lessons related to coronavirus for the government to …

Covid-19 Y Autismo: Impacto En Las Personas Con Autismo Y Sus Familias En Uruguay, Gabriela Garrido, María Cecilia Montenegro, Cecilia Amigo, Daniel Valdez, Natalia Barrios, Sebastián Cukier, Alexia Rattazzi, Analía Rosoli, Ricardo García, Cecilia Montiel-Nava

Psychological Science Faculty Publications

La pandemia de covid-19 y las medidas asociadas determinaron cambios profundos en los individuos con trastorno del espectro autista (TEA) y sus familias. Se busca explorar estos efectos a nivel de las emociones y comportamientos en esta población en Uruguay. Dentro de un estudio multicéntrico de ocho países de Latinoamérica, se utilizó la submuestra de Uruguay para analizar los cambios de los comportamientos exhibidos por los individuos con TEA sobre la base de género y edad. Entre los 269 cuidadores que completaron una encuesta anónima, el 43,9 % reportó mayores problemas de convivencia y el 75,4 % reportó retrocesos. El …

Transmission Event Of Sars-Cov-2 Delta Variant Reveals Multiple Vaccine Breakthrough Infections, Timothy Farinholt, Harsha Doddapaneni, Xiang Qin, Vipin Menon, Qingchang Meng, Ginger Metcalf, Hsu Chao, Marie-Claude Gingras, Vasanthi Avadhanula, Paige Farinholt, Charu Agrawal, Donna M Muzny, Pedro A Piedra, Richard A Gibbs, Joseph Petrosino

Faculty, Staff and Students Publications

BACKGROUND: This study aims to identify the causative strain of SARS-CoV-2 in a cluster of vaccine breakthroughs. Vaccine breakthrough by a highly transmissible SARS-CoV-2 strain is a risk to global public health.

METHODS: Nasopharyngeal swabs from suspected vaccine breakthrough cases were tested for SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) by qPCR (quantitative polymerase chain reaction) for Wuhan-Hu1 and alpha variant. Positive samples were then sequenced by Swift Normalase Amplicon Panels to determine the causal variant. GATK (genome analysis toolkit) variants were filtered with allele fraction ≥80 and min read depth 30x.

RESULTS: Viral sequencing revealed an infection cluster of …

Surgical Stabilization Of Rib Fractures In Symptomatic Covid-19: A Case Report., Jin Wu, Nirvana Saraswat, Kevin Harris, Brent Goslin, William Devoe

Surgery Articles

Severe chest wall injury following trauma is a significant contributing factor to respiratory failure and need for mechanical ventilation in multiply injured patients. Surgical stabilization of rib fractures (SSRF) is increasingly considered to be advantageous in this population. Surgical stabilization has been shown to improve multiple outcomes including ventilator avoidance, liberation from mechanical ventilation, and diminished pulmonary complications in the trauma population, particularly when performed early. During the coronavirus disease 2019 (COVID-19) pandemic, ventilators have become a scarce resource, and conservative strategies have become a critical component of intensive care. We present a report of the perioperative outcome of SSRF …

2021 State Of Nonprofits And Philanthropy Annual Report, Laura Deitrick, Tessa Tinkler, Jon Durnford, Tom Abruzzo, Nallely Manriques, Mehrnoush Jamshidi

State of Nonprofits and Philanthropy in San Diego

The 2021 State of Nonprofits and Philanthropy Annual Report presents findings from ten years of quarterly public opinion polling (San Diego Residents Survey) and nearly 250 survey responses from local nonprofit leaders (Nonprofit Leaders Survey) combined with the latest nonprofit data from the Internal Revenue Service (IRS) and the California Employment Development Department (EDD). Taken together, these data provide a holistic snapshot of San Diego’s nonprofit sector in 2021, summarizing its social and economic contributions to our region, highlighting potential opportunities for greater impact, and drawing our attention to trends which could threaten the nonprofit sector in the future. This …

George-Anne Deep Dive, Georgia Southern University

George-Anne Media Group: Newsletters & Magazines

No abstract provided.

Preparing Nursing Homes For A Second Wave Of Coronavirus Disease 2019 (Covid-19), A Rekha Murthy, Hilary Babcock, Et Al.

2020-Current year OA Pubs

No abstract provided.

Design And Supervision Model Of Group Projects For Active Learning, Yi Meng Lau, Kyong Jin Shim, Swapna Gottipati

Research Collection School Of Computing and Information Systems

This research paper presents a group project framework for a second-year programming course, which was conducted during the COVID-19 pandemic. The framework offers well defined stages of the group project which allow students to work on their choice of a real-world problem, integrate their learnings from previous courses, and present a working solution. In the group project, students actively participate, reflect, and contribute to achieving the goals set in the learning objectives of the course. Our framework incorporates key features from Kolb’s Experiential Learning Theory (1984) and principles of active learning from Barnes (1989) to achieve active and experiential learning …

Perspectives From The Society For Pediatric Research: Advice On Sustaining Science And Mentoring During Covid-19, Catherine S Forster, Suong T Nguyen, Weston T Powell, Daniel J Moore, Jacqueline Ho, Melvin B Heyman, Tara L Wenger, Fernando Gonzalez, Margaret Hostetter, Andrew Nowalk, Caroline E Rassbach, Debra Boyer, Pnina Weiss, Rebecca L Blankenburg, Jordan S Orange, Kate G Ackerman, Audrea M Burns, National Pediatric Physician-Scientist Collaborative Workgroup

Faculty, Staff and Students Publications

The COVID-19 pandemic will leave an indelible mark on the careers of current medical trainees. Given the disruptions to medical education, economic impact on institutions, and the uncertainties around future job prospects, trainees are facing unprecedented challenges. This situation is especially concerning for futures of pediatric physician-scientist trainees, where concerns regarding maintaining the pipeline were well documented prior to the emergence of COVID-19. In this Perspectives article, we leverage the unique expertise of our workgroup to address concerns of physician-scientist trainees and to provide suggestions on how to navigate career trajectories in the post-COVID-19 era. We identified and addressed four …

Neutralisation Of Sars-Cov-2 Lineage P.1 By Antibodies Elicited Through Natural Sars-Cov-2 Infection Or Vaccination With An Inactivated Sars-Cov-2 Vaccine: An Immunological Study, William M Souza, Michael S Diamond, Et Al.

2020-Current year OA Pubs

BACKGROUND: Mutations accrued by SARS-CoV-2 lineage P.1-first detected in Brazil in early January, 2021-include amino acid changes in the receptor-binding domain of the viral spike protein that also are reported in other variants of concern, including B.1.1.7 and B.1.351. We aimed to investigate whether isolates of wild-type P.1 lineage SARS-CoV-2 can escape from neutralising antibodies generated by a polyclonal immune response.

METHODS: We did an immunological study to assess the neutralising effects of antibodies on lineage P.1 and lineage B isolates of SARS-CoV-2, using plasma samples from patients previously infected with or vaccinated against SARS-CoV-2. Two specimens (P.1/28 and P.1/30) …

New Considerations In Designing The Circulation Elements To Reduce Covid 19 Infection, Sara Chamass, Selim Kilani, Anas Mattar

Architecture and Planning Journal (APJ)

As a result of the global pandemic recession of COVID-19, cities have imposed several restrictions to control this outbreak by closing their frontiers and forcing social distancing. The conjecture has arisen as to how architecture could be entirely influenced. This field is involved in finding solutions to reduce the spread of this pandemic which became a new issue. Unfortunately, due to the shortage of the movable and flexible circulation elements, the considerations and architectural preventive measures taken were affected during the planning of the post-pandemic built-environment. This paper, therefore, aims to propose a checklist of new design considerations for the …

Anti-Sars-Cov-2 Monoclonal Antibodies For Early Covid-19: A Real-World Experience, Katherine Belden, Md, Bryan Hess, Md, Caroline Brugger, Crnp, Rachel Carr, Pa, Todd Braun, Md, Joseph Derose, Do, John Zurlo, Md

Division of Infectious Diseases and Environmental Medicine Posters

Higher rates of COVID-19 related hospitalization and death are reported in patients with underlying health conditions and advanced age as compared to the general population.While polyclonal immunity generated by vaccines has demonstrated protection against severe disease, vaccine response takes time and may be inadequate in some high-risk populations.1 Treatment with anti-SARS-CoV-2 neutralizing monoclonal antibodies affords prompt, passive humoral immunity and has been shown in randomized, controlled trials to reduce rates of hospitalization and death from COVID-19 in high-risk ambulatory patients treated early in the course of infection.2,3 The U.S. Food and Drug Administration (FDA) has issued Emergency Use Authorization for …

The Covid-19 Assessment For Survival At Admission (Casa) Index: A 12 Months Observational Study, Gianluca Bagnato, Daniela La Rosa, Carmelo Ioppolo, Alberta De Gaetano, Marianna Chiappalone, Natalia Zirilli, Valeria Viapiana, Maria Concetta Tringali, Simona Tomeo, Caterina Oriana Aragona, Francesca Napoli, Sara Lillo, Natasha Irrera, William Neal Roberts, Egidio Imbalzano, Antonio Micari, Elvira Ventura Spagnolo, Giovanni Squadrito, Sebastiano Gangemi, Antonio Giovanni Versace

Internal Medicine Faculty Publications

Objective: Coronavirus disease 2019 (COVID-19) is a disease with a high rate of progression to critical illness. However, the stratification of patients at risk of mortality is not well defined. In this study, we aimed to define a mortality risk index to allocate patients to the appropriate intensity of care.

Methods: This is a 12 months observational longitudinal study designed to develop and validate a pragmatic mortality risk score to stratify COVID-19 patients aged ≥18 years and admitted to hospital between March 2020 and March 2021. Main outcome was in-hospital mortality.

Results: 244 patients were included in the study (mortality …

Moving Interprofessional Simulation Online: A Lactation Telehealth Virtual Simulation Pilot, Suzanne Hetzel Campbell, Thayanthini Tharmaratnam, Nicole Bernardes, Marianne Brophy, Melanie Willson

General Submissions: Presentations (Oral and Poster)

The pandemic hit the world by surprise, and a continued need for health care professionals meant university programs scrambled for innovative educational options. We will describe the transition to develop and implement a virtual telehealth simulation for interprofessional health care student team.

Covid-19, Policy Responses, And Industrial Productivity Around The Globe, Bernard Njindan Iyke, Susan Sunilla Sharma, Iman Gunadi

Bulletin of Monetary Economics and Banking

We examine whether the COVID-19-induced policy responses by countries moderated the negative impact of the pandemic on industrial productivity. Using a panel of the 50 most affected countries by the pandemic, we show that the policy responses do not only help reduce the spread of COVID-19, but they also moderate its negative impact on industrial productivity and help steer countries back to their growth paths. We demonstrate that, in the absence of the pandemic, some of the policy responses (i.e., lockdowns, travel restrictions, etc.) would have reduced productivity. We further demonstrate that our estimates are robust when considering alternative specifications …

Covid-19 In Silico Drug With Zingiber Officinale Natural Product Compound Library Targeting The Mpro Protein, Renadya Maulani Wijaya, Muhammad Aldino Hafidzhah, Viol Dhea Kharisma, Arif Nur Muhammad Ansori, Arli Aditya Parikesit

Makara Journal of Science

Coronavirus disease 2019 (COVID-19), which is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has become a worldwide pandemic. Ginger (Zingiber officinale) is a rhizome, which is commonly used for culinary and medicinal purposes. In Indonesia, ginger is taken as traditional medicine by processing it into a drink known as jamu. The present study aimed to assess and evaluate the bioactive compounds in ginger that can be used in drug design for treating COVID-19. The crystal structure of the SARS-CoV-2 main protease (M^pro) was generated from a protein sequence database, i.e., Protein Data Bank, …