Digital Commons Network^™

Resilience Of S309 And Azd7442 Monoclonal Antibody Treatments Against Infection By Sars-Cov-2 Omicron Lineage Strains, James Brett Case, Samantha Mackin, John M Errico, Zhenlu Chong, Emily A Madden, Bradley Whitener, Ana Jung, Lindsay Droit, Scott A Handley, Daved H Fremont, Herbert W Virgin, Michael S Diamond, Et Al

2020-Current year OA Pubs

Omicron variant strains encode large numbers of changes in the spike protein compared to historical SARS-CoV-2 isolates. Although in vitro studies have suggested that several monoclonal antibody therapies lose neutralizing activity against Omicron variants, the effects in vivo remain largely unknown. Here, we report on the protective efficacy against three SARS-CoV-2 Omicron lineage strains (BA.1, BA.1.1, and BA.2) of two monoclonal antibody therapeutics (S309 [Vir Biotechnology] monotherapy and AZD7442 [AstraZeneca] combination), which correspond to ones used to treat or prevent SARS-CoV-2 infections in humans. Despite losses in neutralization potency in cell culture, S309 or AZD7442 treatments reduced BA.1, BA.1.1, and …

The Economic Impact Of Covid-19 On Religious Tourism To The Kartarpur Corridor, Farooq Haq, Anita Medhekar

International Journal of Religious Tourism and Pilgrimage

The aim of this paper is to analyse the economic impact of the COVID-19 pandemic on religious tourism in the Kartarpur Gurdwara Corridor between the Punjab States of Pakistan and India. The corridor was opened as a peace building initiative 72 years after the partition of India-Pakistan. In November 2019, thousands of Sikh pilgrims visited Kartarpur and Nankana Sahib in Punjab to celebrate the 550th birth anniversary of the founder of the Sikh religion Guru Nanakji, where he spent last 19 years of his life. The Government of Pakistan invested heavily to build the infrastructure facilities for connecting both borders …

A General Equilibrium Assessment Of Covid-19’S Labor Productivity Impacts On China’S Regional Economies, Xi He, Edward J. Balistreri, Gyu Hyun Kim, Wendong Zhang

Department of Economics: Faculty Publications

This study introduces a database for analyzing COVID-19’s impacts on China’s regional economies. This database contains various sectoral and regional economic outcomes at the weekly and monthly level. In the context of a general equilibrium trade model, we first formulate a mathematical representation of the Chinese regional economy and calibrate the model with China’s multi-regional input-output table. We then utilize the monthly provincial and sectoral value-added and national trade series to estimate COVID-19’s province-by-month labor-productivity impacts from February 2020 to September 2020. As a year-on-year comparison, relative to February 2019 levels, we find an average 39.5% decrease in labor productivity …

Perceptions And Readiness Of Foodservice Establishments At The Onset Of The Covid-19 Pandemic In Metro Manila And Region Iv-A, Philippines, Von Ryan M. Ebron, Irma U. Danao, Marie Faye R. Nguyen- Orca, Anna Teresa O. Orillo, Joyce P. Parco

Journal of Economics, Management and Agricultural Development

The study evaluated the perceptions and readiness of food business operators about COVID-19 through an online survey with respondents from Metro Manila and Region IV-A. Generally, they are knowledgeable about COVID-19 and its transmission, as reflected in their scores. The same is true about their attitude towards “new normal” practices. Years of operation, asset size, and continued operations and delivery services showed significant positive correlation with attitude scores. The resilience of some food business operators may be attributed to having more resources that enabled them to carry the added costs of what the new normal foodservice practices entailed. New normal …

Is Chimpanzee (Pan Troglodytes) Wounding Frequency Affected By The Presence Versus Absence Of Visitors? A Multi-Institutional Study, Robin Elana Salak, Christina Cloutier Barbour

Student Published Works

Visitor effect studies have had inconsistent results, due in part to the inability to control for all confounding variables such as time of day, seasonal weather patterns, and so forth. This study represents the first instance where chimpanzee (Pan troglodytes) wounding frequencies were investigated across extensive time periods in the presence and complete absence of visitors, thus eliminating many visitor-related variables. Additional variables were eliminated through the zoo selection process, based on institutional responses to a 29-question survey, providing a novel approach to the question of visitor effects. The aim of this study was to determine if visitors …

2022-07-01 Michiganoverview_Covidbedppe, Michigan Department Of Health & Human Services

Michigan COVID-19 Hospital Data

Contains the tables Statewide Hospital Capacity Report for COVID-19, COVID-19 Metrics, Statewide Hospital Available PPE Tracking for COVID-19, as well as the tables PPE Days On Hand and Patient Census.

An Investigation Of Anti-Intellectualism Among Nurses, Jamie Davis-Tubbs

Dissertations

Anti-intellectualism is often offered as an explanation for irrational actions, especially in the grips of uncertainty. The effects of the COVID-19 pandemic have uncovered the consequences of anti-intellectualism within the healthcare system. Nurses, the most identifiability trusted healthcare professionals, have been used to illustrate a healthcare paradox regarding COVID-19. The healthcare paradox presents nurses as highly trained healthcare professionals who do not believe in their own science and reject scientific expertise. Furthermore, nursing anti-intellectualism has been used to spread misinformation during a major health crisis. Yet, we do not know the depth in which anti-intellectualism exists within the nursing profession. …

How The Covid-19 Pandemic Has Affected The Mental Health Of Healthcare Workers, Jessica M. Farner

IPS/BAS 495 Undergraduate Capstone Projects

In recent years, healthcare has changed drastically. The outlook healthcare workers have on the environment and the attitudes they carry in their day to day life have been severely affected due to many different reasons, the most recent COVID-19 pandemic being a catalyst. In this paper, I hope to explore and dive more in depth on why this has happened, what can be changed, and the toll it has taken on these front line workers using research found and conducted myself. I located many articles and research studies that discuss the psychological toll the COVID-19 pandemic has taken on healthcare …

Antibody Responses To Sars-Cov-2 After Infection Or Vaccination In Children And Young Adults With Inflammatory Bowel Disease., Joelynn Dailey, Lina Kozhaya, Mikail Dogan, Dena Hopkins, Blaine Lapin, Katherine Herbst, Michael Brimacombe, Kristen Grandonico, Fatih Karabacak, John Schreiber, Bruce Tsan-Liang Liang, Juan C Salazar, Derya Unutmaz, Jeffrey S Hyams

Faculty Research 2022

BACKGROUND: Characterization of neutralization antibodies to SARS-CoV-2 infection or vaccination in children and young adults with inflammatory bowel disease (IBD) receiving biologic therapies is crucial.

METHODS: We performed a prospective longitudinal cohort study evaluating SARS-CoV-2 spike protein receptor binding domain (S-RBD) IgG positivity along with consistent clinical symptoms in patients with IBD receiving infliximab or vedolizumab. Serum was also obtained following immunization with approved vaccines. The IgG antibody to the spike protein binding domain of SARS-CoV-2 was assayed with a fluorescent bead-based immunoassay that takes advantage of the high dynamic range of fluorescent molecules using flow cytometry. A sensitive and …

The Hospitalization Rate Of Cerebral Venous Sinus Thrombosis Before And During Covid-19 Pandemic Era: A Single-Center Retrospective Cohort Study, Maryam Vasaghi Gharamaleki, Maryam Habibagahi, Etrat Hooshmandi, Reza Tabrizi, Shahram Arsang-Jang, Zohreh Barzegar, Nima Fadakar, Vahid Reza Ostovan, Abbas Rahimi-Jaberi, Nahid Ashjazadeh, Peyman Petramfar, Maryam Poursadeghfard, Sadegh Izadi, Masoumeh Nazeri, Hanieh Bazrafshan, Zahra Bahrami, Sedigheh Karimlu, Seyedeh Shaghayegh Zafarmand, Mahnaz Bayat, Mohammad Saied Salehi, Maryam Owjfard, Saeideh Karimi-Haghighi, Anahid Safari, Banafsheh Shakibajahromi, Beng Lim Alvin Chew, Bradford B.G. Worral, Jonathan M. Coutinho, Carlos Garcia-Esperon, Neil Spratt, M Reza Azarpazhooh

Neuroscience Institute Publications

Objectives: There are several reports of the association between SARS-CoV-2 infection (COVID-19) and cerebral venous sinus thrombosis (CVST). In this study, we aimed to compare the hospitalization rate of CVST before and during the COVID-19 pandemic (before vaccination program). Materials and methods: In this retrospective cohort study, the hospitalization rate of adult CVST patients in Namazi hospital, a tertiary referral center in the south of Iran, was compared in two periods of time. We defined March 2018 to March 2019 as the pre-COVID-19 period and March 2020 to March 2021 as the COVID-19 period. Results: 50 and 77 adult CVST …

Covid-19 Infection Enhances Susceptibility To Oxidative Stress-Induced Parkinsonism., Richard Jay Smeyne, Jeffrey B Eells, Debotri Chatterjee, Matthew Byrne, Shaw M Akula, Srinivas Sriramula, Dorcas P O'Rourke, Peter Schmidt

Farber Institute for Neuroscience Faculty Papers

BACKGROUND: Viral induction of neurological syndromes has been a concern since parkinsonian-like features were observed in patients diagnosed with encephalitis lethargica subsequent to the 1918 influenza pandemic. Given the similarities in the systemic responses after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection with those observed after pandemic influenza, there is a question whether a similar syndrome of postencephalic parkinsonism could follow coronavirus disease 2019 infection.

OBJECTIVE: The goal of this study was to determine whether prior infection with SARS-CoV-2 increased sensitivity to a mitochondrial toxin known to induce parkinsonism.

METHODS: K18-hACE2 mice were infected with SARS-CoV-2 to induce mild-to-moderate …

Heart Transplant Recipient 1-Year Outcomes During The Covid-19 Pandemic, Gabriel Esmailian, Nikhil Patel, Jignesh K Patel, Lawrence Czer, Matthew Rafiei, Dominick Megna, Dominic Emerson, Danny Ramzy, Alfredo Trento, Joanna Chikwe, Fardad Esmailian, Jon A Kobashigawa

Faculty, Staff and Student Publications

The COVID-19 pandemic initially brought forth considerable challenges to the field of heart transplantation. To prevent the spread of the virus and protect immunocompromised recipients, our center made the following modifications to post-transplant outpatient management: eliminating early coronary angiograms, video visits for postoperative months 7, 9, and 11, and home blood draws for immunosuppression adjustments. To assess if these changes have impacted patient outcomes, the current study examines 1-year outcomes for patients transplanted during the pandemic. Between March and September 2020, we assessed 50 heart transplant patients transplanted during the pandemic. These patients were compared to patients who were transplanted …

Creating An Effective Social-Emotional Learning Program At The High School Level: A School Improvement Plan, Kassie Bercik

Master's Theses & Capstone Projects

This school improvement plan details the importance of creating an effective social and emotional learning (SEL) program for high school students in the wake of the COVID-19 pandemic and the current mental health crisis among teenagers. Current research points to SEL programs for improvement in nearly all areas for students, whether it be academic achievement, attitude and behavior, resilience, or overall connectedness with peers; furthermore, research also indicates decreases in student aggression and emotional distress. With those findings in mind, this plan was created to focus on the improvement of two specific SEL skills: social awareness and relationship skills. The …

Moral Distress During Covid-19: The Importance Of Perceived Organizational Support For Hospital Nurses, Abigail Latimer, Melanie D. Otis, Gia Mudd-Martin, Debra K. Moser

UK CARES Faculty Publications

Moral distress, or the inability to act congruent with moral beliefs, has been of concern for healthcare professionals especially since the COVID-19 pandemic. Hospital nurses are particularly affected in their roles with mounting administrative pressures and demands. We examined whether general and COVID- specific support in employing healthcare organizations predicted moral distress in a sample of inpatient hospital nurses. A total of 248 nurses completed the Measure of Moral Distress for Healthcare Professionals, Survey of Perceived Organizational Support, COVID Organizational Support survey, and the Hospital Ethical Climate Scale. We found that general and COVID-related organizational support were predictors of moral …

The Covid-19 Pandemic And Associated Increases In Experiences Of Assault Violence Among Black Men With Low Socioeconomic Status Living In Louisiana, Kaylin Beiter, Denise Danos, Erich Conrad, Stephanie Broyles, Jovanny Zabaleta, Jason Mussell, Stephen Phillippi

Population and Public Health Science Faculty Publications

Background: The COVID-19 pandemic has had mental health, social, and economic implications among communities with high levels of social disadvantage; this may have impacted community violence rates. The objective of this study was to characterize overall trends in assault and social disadvantage of patients experiencing assault before and during the COVID-19 pandemic. Methods: All trauma activations at a level one trauma center serving the entire southeast Louisiana region were included during March–August pre-COVID (2018–2019) and during COVID (2020). ICD-10 E-codes were used to identify trauma intent (assault vs. other). Assaults in this context are defined as physical injuries caused by …

The Perfect Storm? Covid-19 And Substance Use Amongst Social Work Students In The Usa, Youn Kyoung Kim, Sung Seek Moon, Mansoo Yu, Mee Young Um, Arati Maleku, Omoshola Kehinde, David Pooler

Faculty Publications

During the COVID-19 pandemic, health risk behaviours related to substance use have been recognised as a significant public health concern amongst university students. Understanding the mechanisms of substance use behaviours, including those used to cope with COVID-19-related stressors, is imperative to curate targeted prevention efforts. To that end, we examined substance use prevalence and its associations with socio-demographic characteristics, preventive behaviours, and mental health amongst US social work students. We collected data from 457 students across all degree levels (BSW, MSW and PhD) from July to August 2020 through an online survey, to examine thirty-day patterns of substance use behaviours …

School Teachers And Principals’ Experiences During Covid-19 In Pakistan, Azra Naseem, Mirat Al Fatima Ahsan, Sohail Ahmad, Tasneem Anwar, Razia Fakir Mohammad

Institute for Educational Development, Karachi

As a result of the COVID-19 pandemic, educational activities were disrupted globally. In Pakistan, schools were also closed, and though some schools had started teaching online, the staff (including principals and teachers) and students' readiness for education during the pandemic remained unexplored. An internet-based survey was conducted to explore the experiences of the teachers and principals during the lockdown. The survey included both open-ended and closed-ended questions. Responses were collected from respondents in different parts of Pakistan, with the majority coming from Sindh and coming from both the private and public sector. While the respondents from private schools reported that …

Impact Of The Covid-19 Pandemic On Daily Life, Mood, And Behavior Of Adults With Down Syndrome, Sigan L. Hartley, Victoria Fleming, Brianna Piro-Gambetti, Annie Cohen, Beau M. Ances, Michael A. Yassa, Adam M. Brickman, Benjamin L. Handen, Elizabeth Head, Mark Mapstone, Bradley T. Christian, Ira T. Lott, Eric Doran, Shahid Zaman, Sharon Krinsky-Mchale, Frederick A. Schmitt, Christy L. Hom, Nicole Schupf

Sanders-Brown Center on Aging Faculty Publications

Background: The Down syndrome population has been disproportionately affected by Coronavirus 2019 (COVID-19) in terms of experiencing severe illness and death. Societal efforts to curb the spread of COVID-19 may also have taken a heavy toll on the daily lives of individuals with Down syndrome.

Objective/hypothesis: The goal of the study was to understand how the COVID-19 pandemic has altered daily life (including residence, employment, and participation in adult disability day programs) and influenced the mood and behavior of adults with Down syndrome.

Methods: Between September 2020 and February 2021, caregivers of 171 adults with Down syndrome (aged …

Culture And Covid-19: Impact Of Cross-Cultural Dimensions On Behavioral Responses, Nisha Nair, Patturaja Selvaraj, Ranjeet Nambudiri

Management Faculty Publications

The global pandemic of COVID-19 has impacted every sphere of human life across all nations of the world. Countries adapted and responded to the crisis in different ways with varied outcomes and different degrees of success in mitigation efforts. Studies have examined institutional and policy-based responses to the pandemic. However, to gain a holistic understanding of the pandemic response strategy and its effectiveness, it is also important to understand the cultural foundations of a society driving its response behavior. Towards that end, this entry focuses on a few key cultural dimensions of difference across countries and proposes that national culture …

Implementation Of A Tier Ii Math Intervention Program, Taylor Torres

Master's Theses & Capstone Projects

The impact of COVID-19 has been detrimental to student success. School closings reduced learning for all students but especially for primary students who missed critical foundational skills. Tier II math interventions within the MTSS framework show evidence of growth for students of all ages and needs. This research-based approach is a logical response to combatting the damage caused by the pandemic. Several successful research studies on mathematics intervention will provide promise of replication in other schools. This school improvement plan will outline actions toward implementing Tier II math interventions in a rural Iowa elementary school.

J Mich Dent Assoc July 2022

The Journal of the Michigan Dental Association

Monthly, The Journal of the Michigan Dental Association brings news, information, and feature articles to our state's oral health community and the MDA's 6,200+ members. No publication reaches more Michigan dentists! In this July 2022 issue, the reader will find the following original content:

• A cover feature on negotiating reimbursement rates with PPO contracts.
• A cover feature on guarding against employee embezzlement.
• A 10-Minute EBD on rampant caries management and prevention with ADHD patients taking stimulant medications.
• A Back Page look at the 2022 MDA award winners.
• News you need: an Editorial, guidance on dental practice cybersecurity, and regular department …

Impact Of The Covid-19 Pandemic On Daily Life, Mood, And Behavior Of Adults With Down Syndrome, Sigan L Hartley, Beau M Ances, Et Al.

2020-Current year OA Pubs

BACKGROUND: The Down syndrome population has been disproportionately affected by Coronavirus 2019 (COVID-19) in terms of experiencing severe illness and death. Societal efforts to curb the spread of COVID-19 may also have taken a heavy toll on the daily lives of individuals with Down syndrome.

OBJECTIVE/HYPOTHESIS: The goal of the study was to understand how the COVID-19 pandemic has altered daily life (including residence, employment, and participation in adult disability day programs) and influenced the mood and behavior of adults with Down syndrome.

METHODS: Between September 2020 and February 2021, caregivers of 171 adults with Down syndrome (aged 22-66 years) …

“Into The Lion’S Den”: Covid-19 Experiences Of Black Adults With Sickle Cell Disease, Nadine Matthie, Dora L. Clayton-Jones, Coretta Jenerette

College of Nursing Faculty Research and Publications

Adults living with sickle cell disease are at risk for experiencing severe illness from coronavirus disease 2019 (COVID-19) due to the complexity of their disease. Additionally, self-management and navigating the healthcare system may be challenging during the COVID-19 pandemic. Therefore, we conducted telephone interviews with 25 participants to explore the experiences of Black adults living with sickle cell disease during the early months of the pandemic in the United States. Three overarching themes characterize their experiences: management of sickle cell disease was further complicated by the pandemic, fear of the virus contributed to physical and social isolation, and employment and …

Association Between The Covid-19 Pandemic And Insurance-Based Disparities In Mortality After Major Surgery Among Us Adults, Laurent G Glance, Andrew W Dick, Ernie Shippey, Patrick J Mccormick, Richard Dutton, Patricia W Stone, Jingjing Shang, Stewart J Lustik, Heather L Lander, Igor Gosev, Karen E Joynt Maddox

2020-Current year OA Pubs

Importance: The COVID-19 pandemic caused significant disruptions in surgical care. Whether these disruptions disproportionately impacted economically disadvantaged individuals is unknown.

Objective: To evaluate the association between the COVID-19 pandemic and mortality after major surgery among patients with Medicaid insurance or without insurance compared with patients with commercial insurance.

Design, Setting, and Participants: This cross-sectional study used data from the Vizient Clinical Database for patients who underwent major surgery at hospitals in the US between January 1, 2018, and May 31, 2020.

Exposures: The hospital proportion of patients with COVID-19 during the first wave of COVID-19 cases between March 1 and …

Worldwide Consequences Of Covid-19 On Research In Stem, Michelle Hoang, Santanu De

Biology Faculty Articles

A global public health emergency like the Coronavirus Infectious Disease 2019 (COVID-19) pandemic requires accurate and timely data collection in the research community. High-impact research in science, technology, engineering, and mathematics (STEM) has been prioritized in the fight against COVID-19. The present study analyzed the consequences of COVID-19 on STEM research and the collaboration between research institutions and industries worldwide. It was noted that COVID19 had caused significant delays in non-COVID-19-related research projects and the onset of several remote studies. Most importantly, researchers in the STEM fields directed their attention and expertise to help mitigate virus transmission, treat patients, and …

Health Inequities As Measured By The Eq-5d-5l During Covid-19: Results From New York In Healthy And Diseased Persons, Erica I. Lubetkin, Di Long, Juanita A. Haagsma, Mathieu F. Janssen, Gouke J. Bonsel

Publications and Research

Introduction: The effects of the COVID-19 pandemic caused considerable psychological and physical effects in healthy and diseased New Yorkers aside from the effects in those who were infected. We investigated the relationship between known risk-enhancing and health-promoting factors (social and medical), comorbidity indicators, and, as the primary outcome, health-related quality of life (HRQoL).

Methods: Between April 22 and May 5, 2020, a market research agency (Dynata) administered a digital survey including the EQ-5D-5L and items related to individual characteristics, social position, occupational and insurance status, living situation, exposures (smoking and COVID-19), detailed chronic conditions, and experienced access to care to …

The Impacts Of Ownership And Covid-19 On Firm Performance-Three Essays, Jian Xu

Theses and Dissertations

This dissertation consists of three essays on finance of ownership and COVID-19. In the first essay, we investigate the effect of residual state ownership, foreign ownership, and the interaction between the two on firms' financing patterns. we find that neither firms with residual state ownership only nor firms with foreign ownership only are positively related with external finance. In comparison, firms with both state and foreign ownerships are associated with higher external finance. The increased external finance for firms with both state and foreign ownerships mainly comes from private banks and new equity. Moreover, we explore the channels through which …

On Precaution Versus Covid-19: Are People Really Complacent?, Renz Adrian T. Calub

DLSU Business & Economics Review

As of this writing, the Philippines is experiencing a surge in COVID-19, a year after implementing nationwide lockdowns and curfews. Although vaccines are being shipped and rolled out, the country appears to be regressing, with hospitals being filled to the brim. Complacency has been the usual suspect, with the government blaming individuals and business establishments for not staying at home and for not observing the minimal health protocols. But are people really complacent? This paper develops a simple game to address such a question.

Universities In And Beyond A Pandemic, Lily Kong, Sovan Patra

Research Collection School of Social Sciences

The impact of the COVID pandemic, and concomitant public health interventions, on university operations and finances is unprecedented in its scope and scale. This chapter provides, firstly, a panorama of the challenges of tertiary teaching and learning in a socially distanced world as well as of the fiscal impact of the pandemic on universities. Secondly, it is an experience-informed personal reflection on the lessons that university instructors, researchers, and leaders can learn from the events of the past year to be more effective in sub-optimal environments, both as individuals and as members of the larger society. Finally, it presents an …

Vaccine Hesitancy And Betrayal Aversion, Abdelaziz Alsharawy, Esha Dwibedi, Jason Aimone, Sheryl Ball

Faculty, Staff and Student Publications

The determinants of vaccine hesitancy remain complex and context specific. Betrayal aversion occurs when an individual is hesitant to risk being betrayed in an environment involving trust. In this pre-registered vignette experiment, we show that betrayal aversion is not captured by current vaccine hesitancy measures despite representing a significant source of unwillingness to be vaccinated. Our survey instrument was administered to 888 United States residents via Amazon Mechanical Turk in March 2021. We find that over a third of participants have betrayal averse preferences, resulting in an 8-26% decline in vaccine acceptance, depending on the betrayal source. Interestingly, attributing betrayal …