Digital Commons Network^™

Effect Of Angiotensin-Converting Enzyme Inhibitor And Angiotensin Receptor Blocker Initiation On Organ Support-Free Days In Patients Hospitalized With Covid-19: A Randomized Clinical Trial, Patrick R Lawler, Lennie P G Derde, Frank L Van De Veerdonk, Bryan J Mcverry, David T Huang, Lindsay R Berry, Elizabeth Lorenzi, Roland Van Kimmenade, Frank Gommans, Muthiah Vaduganathan, David E Leaf, Rebecca M Baron, Edy Y Kim, Claudia Frankfurter, Slava Epelman, Yvonne Kwan, Richard Grieve, Stephen O'Neill, Zia Sadique, Michael Puskarich, John C Marshall, Alisa M Higgins, Paul R Mouncey, Kathryn M Rowan, Farah Al-Beidh, Djillali Annane, Yaseen M Arabi, Carly Au, Abi Beane, Wilma Van Bentum-Puijk, Marc J M Bonten, Charlotte A Bradbury, Frank M Brunkhorst, Aidan Burrell, Adrian Buzgau, Meredith Buxton, Maurizio Cecconi, Allen C Cheng, Matthew Cove, Michelle A Detry, Lise J Estcourt, Justin Ezekowitz, Mark Fitzgerald, David Gattas, Lucas C Godoy, Herman Goossens, Rashan Haniffa, David A Harrison, Thomas Hills, Christopher M Horvat, Nao Ichihara, Francois Lamontagne, Kelsey M Linstrum, Daniel F Mcauley, Anna Mcglothlin, Shay P Mcguinness, Zoe Mcquilten, Srinivas Murthy, Alistair D Nichol, David R J Owen, Rachael L Parke, Jane C Parker, Katrina M Pollock, Luis Felipe Reyes, Hiroki Saito, Marlene S Santos, Christina T Saunders, Christopher W Seymour, Manu Shankar-Hari, Vanessa Singh, Alexis F Turgeon, Anne M Turner, Ryan Zarychanski, Cameron Green, Roger J Lewis, Derek C Angus, Scott Berry, Anthony C Gordon, Colin J Mcarthur, Steve A Webb

Faculty, Staff and Student Publications

IMPORTANCE: Overactivation of the renin-angiotensin system (RAS) may contribute to poor clinical outcomes in patients with COVID-19.

OBJECTIVE: To determine whether angiotensin-converting enzyme (ACE) inhibitor or angiotensin receptor blocker (ARB) initiation improves outcomes in patients hospitalized for COVID-19.

DESIGN, SETTING, AND PARTICIPANTS: In an ongoing, adaptive platform randomized clinical trial, 721 critically ill and 58 non-critically ill hospitalized adults were randomized to receive an RAS inhibitor or control between March 16, 2021, and February 25, 2022, at 69 sites in 7 countries (final follow-up on June 1, 2022).

INTERVENTIONS: Patients were randomized to receive open-label initiation of an ACE inhibitor …

Transition To Distance Learning: Student Experience And Communication During The Covid-19 Pandemic In The United Arab Emirates, Soumaya Abdellatif, Aizhan Shomotova, Safouane Trabelsi, Salwa Husain, Najeh Alsalhi, Mohamed Eltahir

All Works

The COVID-19 pandemic in 2020 prompted higher education institutions in the United Arab Emirates (UAE) to switch to online learning for the safety of their citizens. The main purpose of this study is to determine the relationship between four indicators of digital learning experience and the intensity of student socio-pedagogical communication after the transition to distance learning. The data were collected from Ajman University, a private university in the UAE, during the spring of 2020. The sample consisted of 381 students who were surveyed using an online survey tool or email. First, this study found that the majority of students …

Perceived Feelings And Dyspnea During Maximal Exercise Testing With Different Masks: A Randomized Crossover Study, Rickmann Pluviose, Alejandra Rincon Cortes, Andreas Stamatis Dr., Zacharias Papadakis

International Journal of Exercise Science: Conference Proceedings

The COVID-19 pandemic prompted the widespread use of facemasks. Concerns were raised about their comfort and functionality during exercise. Research on the subjective experiences of exercisers wearing masks during high levels of intensity is scarce. PURPOSE: To examine the sensational perceptions related to facemasks and maximal exercise testing. METHODS: The study utilized a randomized crossover design. Five participants completed a maximum Bruce protocol while wearing a surgical (SM), cloth (CM), N95 (N95), or no mask (NM). Their perceptual responses were collected at a pre-exercise (PRE), Respiratory Exchange Ratio of 1.0 (RER_1.0), and immediately post-exercise (IPE), using Feeling …

Effect Of Last Meal Timing On Sleep Efficiency In College Students During Covid-19, Nicole Hayes, Zacharias Papadakis Facsm, Ali Boolani, Andreas Stamatis Facsm

International Journal of Exercise Science: Conference Proceedings

Sleep efficiency (SE), the proportion of total sleep time to total time spent in bed, has established associations with various health and disease outcomes. Notably, the interval time between the last meal and bedtime has been shown to influence SE. Recent studies indicate that the COVID-19 pandemic has resulted in significant disruptions to the eating and sleeping patterns of college students. PURPOSE: To explore changes in college students’ SE in relation to the timing of their last meal and bedtime during COVID-19. METHODS: We collected data from 123 college students (m_age = 19.3 years, SD = 0.97; 58 …

Screen Time And Mental Work In College Students During Covid-19: Implications For Occupational Therapy, Gabriela Herrera, Zacharias Papadakis Facsm, Ali Boolani, Andreas Stamatis Facsm

International Journal of Exercise Science: Conference Proceedings

Due to stay-at-home orders and remote learning, the COVID-19 crisis has led to increased screen time (ST) on phone/tv among college students. Prolonged ST can negatively impact mental work (MW), which encompasses the mental processes and efforts utilized when performing tasks requiring cognitive effort and attention. During this health crisis, occupational therapists (OTs) have been working with students to improve their mental well-being and cognitive function at school, through activities and exercises designed to enhance mental capacity. Longitudinal research is still needed to fully understand the extent of the relationship between ST and MW and identify interventions that can reduce …

Internet Usage During And Post Covid-19 Pandemic: A Study On The Students Of Information Science And Library Management In The University Of Rajshahi, Bangladesh., Zihadur Rahman, Md. Armanul Haque, Dil Afroz Bente Aziz

Library Philosophy and Practice (e-journal)

Abstract

Purpose

The COVID-19 epidemic significantly impacted daily life and led to the adoption of significant steps to stop the virus's spread. Educational institutions and social gatherings were placed on prolonged lockdown, with people continuing to maintain physical distance. As a result, students of all classes are highly engaged in using the internet. In this article, the usage of the internet of the student's Information Science and Library Management, University of Rajshahi are studied. The aim of the present study was to examine the usage of the internet during the post-pandemic. Furthermore, this research aims to investigate the internet usage …

2023-04-10_Michiganoverview_Covidbedppe, Michigan Department Of Health & Human Services

Michigan COVID-19 Hospital Data

Contains the tables Statewide Hospital Capacity Report for COVID-19, COVID-19 Metrics, Statewide Hospital Available PPE Tracking for COVID-19, as well as the tables PPE Days On Hand and Patient Census.

Last Winter’S Tripledemic: A Multi-Factorial Syndrome Of Respiratory Illness, Kara Hom

URGENT Matters

No abstract provided.

2023-04-07_Michiganoverview_Covidbedppe, Michigan Department Of Health & Human Services

Michigan COVID-19 Hospital Data

Contains the tables Statewide Hospital Capacity Report for COVID-19, COVID-19 Metrics, Statewide Hospital Available PPE Tracking for COVID-19, as well as the tables PPE Days On Hand and Patient Census.

Metabolic Dysregulation Impairs Lymphocyte Function During Severe Sars-Cov-2 Infection, Sanjeev Gurshaney, Anamaria Morales-Alvarez, Kevin Ezhakunnel, Andrew Manalo, Thien-Huong Huynh, Jun-Ichi Abe, Nhat-Tu Le, Daniela Weiskopf, Alessandro Sette, Daniel S Lupu, Stephen J Gardell, Hung Nguyen

Faculty, Staff and Student Publications

Cellular metabolic dysregulation is a consequence of SARS-CoV-2 infection that is a key determinant of disease severity. However, how metabolic perturbations influence immunological function during COVID-19 remains unclear. Here, using a combination of high-dimensional flow cytometry, cutting-edge single-cell metabolomics, and re-analysis of single-cell transcriptomic data, we demonstrate a global hypoxia-linked metabolic switch from fatty acid oxidation and mitochondrial respiration towards anaerobic, glucose-dependent metabolism in CD8+Tc, NKT, and epithelial cells. Consequently, we found that a strong dysregulation in immunometabolism was tied to increased cellular exhaustion, attenuated effector function, and impaired memory differentiation. Pharmacological inhibition of mitophagy with mdivi-1 reduced excess glucose …

Understanding An Urban Black Worldview: A Phenomenological Examination Of 2020, Gershwin Francis Grant

Doctoral Dissertations and Projects

This action research project was designed to surface and codify a worldview that emerged among black people as a result of the traumatic phenomena of 2020. The program sought to help white pastors in New York’s Lower Hudson Valley recognize this new worldview, understand its implications, and desire to intentionally develop their level of Cultural Competence to more effectively counsel and disciple black congregants holding this worldview. The detrimental effects of the phenomena of 2020 exacerbated existing trauma caused by social and institutional racism and resulted in an altered worldview among urban blacks affecting relationships in communities and within church …

A Phenomenological Study Of The Perceived Influence That Generation Z Has On The Revitalization Of A Church, Linda Proctor Mathis

Doctoral Dissertations and Projects

The purpose of this qualitative phenomenological study was to explore the perceived influence that Generation Z had upon the revitalization of a church following its in-person decline as a result of the coronavirus in 2020 (Barna, 2020; Braddy, 2021; Earls, 2020). The theory that guided this study was based on research conducted by Lifeway Research, Pew Research, and Barna Group Research concerning Generation Z and based upon the book, You Lost Me: Why Young Christians Are Leaving Church…And Rethinking Faith, by David Kinnaman of Barna Research. The theories proposed within the books, Essential Church? Reclaiming a Generation of Dropouts by …

A Phenomenological Study Of Parents Accessing And Receiving Professional Care For Their Child With Autism Spectrum Disorder (Asd) During The Covid-19 Outbreak In Washington State, Patrick Michael Barry

Doctoral Dissertations and Projects

COVID-19 changes and restrictions have necessitated a change in the way schools, mental health providers, medical providers, and other educational and therapy services provide for children with autism. This study explores, in-depth, the experience of parents of children with ASD as they have navigated the COVID-19 required changes to professional treatment and services for children with ASD and their families. Research suggests that raising a child with an autism spectrum disorder (ASD) can be an overwhelming experience for parents and families, and greater family burden is positively associated with the number of unmet professional help service needs. As services were …

K-12 Florida Christian Schools In Crisis: A Correlational Study Of Educational Leadership During The Covid-19 Pandemic, Cesar O. Irizarry

Doctoral Dissertations and Projects

K-12 Florida Christian schools were disrupted due to the advent of a global crisis brought about by the COVID-19 pandemic. Flexibility was needed by educational leadership during this time of crisis. For that reason, this study will aim to understand the leadership principles necessary to provide leaders with the flexibility to adapt to extreme circumstances. The literature addresses the leader’s importance of being flexible during a crisis (Ruffner & Huizing, 2016). However, the literature continues to examine the effects of the pandemic on education but has not identified those contingencies that are necessary for leaders in the Christian educational system …

Progressive Muscle Relaxation Exercises In Patients With Covid-19: Systematic Review And Meta-Analysis, Abubeker Alebachew Seid, Ahmed Adem Mohammed, Aragaw Asfaw Hasen

Faculty, Staff and Student Publications

BACKGROUND: Patients with COVID-19 will experience high levels of anxiety and depression and poor levels of sleep and quality of life (QoL) due to isolation treatment and uncertain outcomes. Progressive muscle relaxation (PMR) exercises show promising treatment effects on mental health and sleep problems and overall QoL in COVID-19 patients. This study aimed to evaluate the efficacy and safety of PMR exercises in patients with COVID-19.

METHODS: Both experimental and non-experimental studies related to PMR and COVID-19 were systematically searched in the PubMed, Cochrane Library, PEDro and HINARI databases for studies published from the occurrence of the pandemic to December …

Alcohol-Associated Liver Disease Mortality Rates By Race Before And During The Covid-19 Pandemic In The Us, Neeti S Kulkarni, Divneet K Wadhwa, Fasiha Kanwal, Jagpreet Chhatwal

Faculty, Staff and Students Publications

This cross-sectional study examines the national- and state-level age-adjusted mortality rates for alcohol-associated liver disease in 4 racial groups, with a focus on the American Indian or Alaska Native population.

2023-04-06_Michiganoverview_Misc, Michigan Department Of Health & Human Services

Michigan COVID-19 MIS-C Data

The MIS-C Data page was obtained from Michigan's COVID-19 data page: https://www.michigan.gov/coronavirus/stats/mis-c-reporting.

This report is created by the Michigan Department of Health & Human Services from data self-reported by health care providers and local health departments. Data is updated on the first and third Thursdays of the month.

Multisystem Inflammatory Syndrome in Children (MIS-C) is a condition in children and adolescents under 21 years of age where multiple organ systems become inflamed or dysfunctional which occurs in association with illness. Children with MIS-C may have a fever and various symptoms, including abdominal (gut) pain, vomiting, diarrhea, neck pain, rash, …

Without A Village: Motherhood, Child Care And Covid-19, Bailey Higgins

Social Work Doctoral Dissertations

As part of a feminist hermeneutic phenomenological study, mothers of children who had not yet entered kindergarten and who had used child care outside of the home during the COVID-19 pandemic were interviewed about their experiences of motherhood, use of child care, and COVID-19 after the US lockdown orders were lifted in late 2020. Informed by the matricentric feminist perspective, which promotes the enfranchisement of mothers, the study aimed to inform social work practice for mothers and advocacy for employed mothers of young children.

Exploring the experiences of mothers was completed by collecting narratives utilizing a semi-structured interview. Findings from …

Factor Xa Cleaves Sars-Cov-2 Spike Protein To Block Viral Entry And Infection, Wenjuan Dong, Sean P J Whelan, Et Al.

2020-Current year OA Pubs

Serine proteases (SP), including furin, trypsin, and TMPRSS2 cleave the SARS-CoV-2 spike (S) protein, enabling the virus to enter cells. Here, we show that factor (F) Xa, an SP involved in blood coagulation, is upregulated in COVID-19 patients. In contrast to other SPs, FXa exerts antiviral activity. Mechanistically, FXa cleaves S protein, preventing its binding to ACE2, and thus blocking viral entry and infection. However, FXa is less effective against variants carrying the D614G mutation common in all pandemic variants. The anticoagulant rivaroxaban, a direct FXa inhibitor, inhibits FXa-mediated S protein cleavage and facilitates viral entry, whereas the indirect FXa …

Now What?, David L. Hart Jr, Rebecca J. Armstrong

FDLA Journal

NOW WHAT?

David Hart, Ph.D. and Rebecca Armstrong, Ph.D.

Making the decision to pursue an advanced degree is certainly commendable. To add to one’s knowledge base is ambitious and the results of such a commitment are monumental. However, it goes without saying that in that scheme, life’s challenges are ever-present, and along with other given responsibilities, the concept of time becomes a faded memory. If that is not enough, COVID-19 presented all degree-seekers with issues that seemed insurmountable. Many decided that virtual learning programs would provide an environment that allowed for success in the academic arena despite the forces that …

2023-04-05_Michiganoverview_Covidbedppe, Michigan Department Of Health & Human Services

Michigan COVID-19 Hospital Data

Contains the tables Statewide Hospital Capacity Report for COVID-19, COVID-19 Metrics, Statewide Hospital Available PPE Tracking for COVID-19, as well as the tables PPE Days On Hand and Patient Census.

Cross-Sectional Study To Assess Depression Among Healthcare Workers In Lusaka, Zambia During The Covid-19 Pandemic, Sandra Simbeza, Jacob Mutale, Musunge Mulabe, Lazarus Jere, Chama Bukankala, Kombatende Sikombe, Izukanji Sikazwe, Carolyn Bolton-Moore, Aaloke Mody, Elvin H. Geng, Anjali Sharma, Laura K. Beres, Jake M. Pry

2020-Current year OA Pubs

OBJECTIVES: We sought to assess depression among healthcare workers (HCWs) in the context of COVID-19 in Lusaka Province, Zambia.

DESIGN: This cross-sectional study is nested within a larger study, the Person-Centred Public Health for HIV Treatment in Zambia (PCPH), a cluster-randomised trial to assess HIV care and outcomes.

SETTING: The research was conducted in 24 government-run health facilities from 11 August to 15 October 2020 during the first wave of the COVID-19 pandemic in Lusaka, Zambia.

PARTICIPANTS: We used convenience sampling to recruit HCW participants who were previously enrolled in the PCPH study, had more than 6 months' experience working …

Shifting Into “Neutral”: Evaluating Mediation As A Peaceful Alternative To The Forceful Resolution Of The 2022 Canada–Freedom Convoy Dispute, Teresa (Tessa) Griego

Pepperdine Dispute Resolution Law Journal

In early 2022, the Canadian government found itself confronted by a group of truck drivers—in what came to be known as the “Freedom Convoy”—protesting government-imposed restrictions related to the COVID-19 pandemic. This article evaluates how mediation could—and should—have been used as an effective means for the government and protestors to resolve their dispute. It begins by defining the government health and safety measures that prompted the protests and describing the ensuing protest movement by the Freedom Convoy. The article then discusses the protest’s implications on commerce and on the communities where it was located. Next, the article describes the unilateral …

2023-04-04_Michiganoverview_Covidlongtermcare, Michigan Department Of Health & Human Services

Michigan COVID-19 Long Term Care Data

The COVID Long Term Care Facilities page was obtained from Michigan's COVID-19 data page: https://www.michigan.gov/coronavirus/stats/data-about-places/long-term-care-data.

This report is created by the Michigan Department of Health & Human Services from data self-reported by long-term care facilities into EMResource. Data for all reporting facilities is posted weekly each Monday.

The information below represents COVID-19 data reported directly to MDHHS by licensed and operating Skilled Nursing, Home for the Aged and Adult Foster Care facilities (licensed to serve 13 or more individuals) in Michigan from January 1, 2020. All long-term care facilities additionally have an obligation to report COVID-positive residents and/or staff …

2023-04-04_Michiganoverview_Covidstats, Michigan Department Of Health & Human Services

Cumulative Michigan COVID-19 Data

The COVID Overview page was obtained from Michigan's main COVID-19 page: https://www.michigan.gov/coronavirus/stats.

The State of Michigan is working around the clock to test and treat COVID-19 patients. Below is the most recent data healthcare experts across the state have compiled. COVID case and testing data will be posted once a week on Tuesdays.

This report is provisional and subject to change. City of Detroit and Wayne County are reported separately. MDHHS began tracking probable cases April 5, 2020. FCI indicates federal correctional institute. MDOC indicates Michigan Department of Corrections. Diagnostic tests, including nucleic acid amplification/real-time polymerase chain reaction (NAAT/RT-PCR) …

Blockchain Accelerators And An Application On Covid-19 Contact Tracing, Tao Lu

LSU Doctoral Dissertations

Blockchain technology has been an emerging technology in recent years. Its nature of decentralization and anonymity enables many applications to be built in a trustless environment but can still be validated and agreed upon by all the participants. Ever since the invention of blockchain technology, its concepts and forms are explored extensively, and it has shown the potential to be used in many industries. However, the low efficiency and the poor performance have prevented the technology to be adopted in practical largescale usage. In this dissertation, we present three major works around blockchain technology. The first one is BPU, an …

A Study On The Occurrence Of Hand Dermatitis In Healthcare Workers During The Covid-19 Pandemic Due To Enhanced Hand Hygiene, Abhishree Bs, Kavitha R, Geetha A

Pharmacology and Clinical Pharmacy Research

Hand hygiene measures have increased in the general population and amongst the health care workers since the outbreak of the pandemic. However, enhanced hand hygiene can have an adverse effect on the skin barrier leading to the development of hand dermatitis. The aim of the study was to determine the occurrence of occupational-related contact dermatitis among the health care workers. An observational, questionnaire based cross-sectional study was conducted in 2021 amongst HCWs of a tertiary care hospital. The data were analysed using Microsoft Excel for Windows. The frequency of hand washing had increased to > 5 times in 42% of the …

The Effects Of Racism And Resilience On Black Stroke- Survivor Quality Of Life: Study Protocol And Rationale For A Mixed-Methods Approach, Xiude Fan, Junming Han, Enfa Zhao, Jiansong Fang, Dawei Wang, Yiping Cheng, Yingzhou Shi, Zhen Wang, Zhenyu Yao, Peng Lu, Tianbao Liu, Qihang Li, Kyle L Poulsen, Zhongshang Yuan, Yongfeng Song, Jiajun Zhao

Faculty, Staff and Student Publications

Breakthrough SARS-CoV-2 infections of vaccinated individuals are being reported globally, resulting in an increased risk of hospitalization and death among such patients. Therefore, it is crucial to identify the modifiable risk factors that may affect the protective efficacy of vaccine use against the development of severe COVID-19 and thus to initiate early medical interventions. Here, in population-based studies using the UK Biobank database and the 2021 National Health Interview Survey (NHIS), we analyzed 20,362 participants aged 50 years or older and 2,588 aged 18 years or older from both databases who tested positive for SARS-COV-2, of whom 33.1% and 67.7% …

The Effect Of Lockdowns On The Status Of Women In The World, Angelika B. Magno

Angelo King Institute for Economic and Business Studies (AKI)

Coronavirus disease (COVID-19) is an infectious respiratory illness that causes moderate to severe symptoms that can be fatal to older people or those with other underlying health concerns. Considered a global pandemic, this disease spreads rapidly across the world, calling for a need for the implementation of lockdowns. This study examines the effects of lockdowns on joblessness among women, controlling for household conditions, namely, perceived household responsibility, hours allotted for household chores, and safety at home. Data for lockdowns were sourced from Google’s Community Mobility reports, whereas joblessness among women and household conditions were sourced from Facebook’s Survey on Gender …

2023-04-03_Michiganoverview_Covidbedppe, Michigan Department Of Health & Human Services

Michigan COVID-19 Hospital Data

Contains the tables Statewide Hospital Capacity Report for COVID-19, COVID-19 Metrics, Statewide Hospital Available PPE Tracking for COVID-19, as well as the tables PPE Days On Hand and Patient Census.