Digital Commons Network^™

Symptom Duration And Resolution With Early Outpatient Treatment Of Convalescent Plasma For Coronavirus Disease 2019: A Randomized Trial, Sheriza N. Baksh, Sonya L. Heath, Yuriko Fukuta, David Shade, Barry Meisenberg, Evan M. Bloch, Aaron A R Tobian, Emily S. Spivak, Bela Patel, Jonathan Gerber, Jay S. Raval, Donald Forthal, James Paxton, Giselle Mosnaim, Shweta Anjan, Janis Blair, Edward Cachay, Judith Currier, Piyali Das, Moises Huaman, Catherine Sutcliffe, Anusha Yarava, Arturo Casadevall, David Sullivan, Daniel Hanley, Kelly A Gebo

Pathology Research and Scholarship

BACKGROUND: Coronavirus disease 2019 (COVID-19) convalescent plasma (CCP) reduces hospitalizations among outpatients treated early after symptom onset. It is unknown whether CCP reduces time to symptom resolution among outpatients.

METHODS: We evaluated symptom resolution at day 14 by trial arm using an adjusted subdistribution hazard model, with hospitalization as a competing risk. We also assessed the prevalence of symptom clusters at day 14 between treatments. Clusters were defined based on biologic clustering, impact on ability to work, and an algorithm.

RESULTS: Among 1070 outpatients followed up after transfusion, 381 of 538 (70.8%) receiving CCP and 381 of 532 (71.6%) receiving …

Nutrition In Times Of Crisis: A Qualitative Study In Siargao Island, Philippines, During The Covid-19 Pandemic, Gideon Lasco, Vincen Gregory Yu, Julie Madelo Compra, Phetdavanh Leuangvilay, Rapeepong Suphanchaimat, Yunting Zhang, Charina Javier

Development Studies Faculty Publications

Objectives

Despite the public-health significance of both malnutrition and crises, little has been done to explore the convergence of the two domains and develop ways to improve policies and practices, especially in rural communities. This article remedies that knowledge gap by focusing on nutrition-related changes, responses, and practices during crisis situations in Siargao Island, Philippines, using the COVID-19 pandemic as a backdrop.

Methods

Forty-six (46) semi-structured interviews were conducted among parents, caregivers, local health workers, and local officials of Del Carmen, Siargao Island. Principles of thematic analysis were applied to data analysis using NVivo 12. Afterwards, the preliminary data were …

Symptom Duration And Resolution With Early Outpatient Treatment Of Convalescent Plasma For Coronavirus Disease 2019: A Randomized Trial, Sheriza N Baksh, Sonya L Heath, Yuriko Fukuta, David Shade, Barry Meisenberg, Evan M Bloch, Aaron A R Tobian, Emily S Spivak, Bela Patel, Jonathan Gerber, Jay S Raval, Donald Forthal, James Paxton, Giselle Mosnaim, Shweta Anjan, Janis Blair, Edward Cachay, Judith Currier, Piyali Das, Moises Huaman, Catherine Sutcliffe, Anusha Yarava, Arturo Casadevall, David Sullivan, Daniel Hanley, Kelly A Gebo

Faculty, Staff and Students Publications

BACKGROUND: Coronavirus disease 2019 (COVID-19) convalescent plasma (CCP) reduces hospitalizations among outpatients treated early after symptom onset. It is unknown whether CCP reduces time to symptom resolution among outpatients.

METHODS: We evaluated symptom resolution at day 14 by trial arm using an adjusted subdistribution hazard model, with hospitalization as a competing risk. We also assessed the prevalence of symptom clusters at day 14 between treatments. Clusters were defined based on biologic clustering, impact on ability to work, and an algorithm.

RESULTS: Among 1070 outpatients followed up after transfusion, 381 of 538 (70.8%) receiving CCP and 381 of 532 (71.6%) receiving …

Pandemic Upon Pandemic: Middle-Aged And Older Men Who Have Sex With Men Living With Hiv Coping And Thriving During The Peak Of Covid-19, Sherry Bell, Brandon Ranuschio, John M. Waldron, Lianne Barnes, Nadia Sheik-Yosef, Esmeralda Villalobos, Janelle Wackens, Renato M. Liboro

Psychology Faculty Research

When the COVID-19 pandemic emerged in early 2020, not only did it abruptly impede the progress that was being made toward achieving global targets to end the HIV pandemic, but it also created significant impacts on the physical and mental health of middle-aged and older men who have sex with men living with HIV. Utilizing a qualitative, community-based participatory research approach, we conducted semi-structured, one-on-one interviews with 16 ethnoracially diverse, middle-aged and older men who have sex with men living with HIV residing in Southern Nevada, to examine the different ways the COVID-19 pandemic directly impacted their physical and mental …

Binge Drinking Alcohol And Circadian Misalignment In Night Shift Nurses Is Associated With Decreased Resiliency To Covid-19 Infection, Garth R. Swanson, Benjamin A. Schwartz, Cara Joyce, Ali Keshavarzian

Biostatistics Collaborative Core: Faculty Publications and Other Works

Background: Nurses and other first responders are at high risk of exposure to the SARS-CoV2 virus, and many have developed severe COVID-19 infection. A better understanding of the factors that increase the risk of infection after exposure to the virus could help to address this. Although several risk factors such as obesity, diabetes, and hypertension have been associated with an increased risk of infection, many first responders develop severe COVID-19 without established risk factors. As inflammation and cytokine storm are the primary mechanisms in severe COVID-19, other factors that promote an inflammatory state could increase the risk of COVID-19 in …

Nailfold Videocapillaroscopic Alterations As Markers Of Microangiopathy In Covid-19 Patients, Roberta Gualtierotti, Sharon E. Fox, Fernanda Da Silva Lameira, Andrea Giachi, Luca Valenti, Maria Orietta Borghi, Pier Luigi Meroni, Massimo Cugno, Flora Peyvandi

School of Medicine Faculty Publications

Nailfold videocapillaroscopic alterations have been described in COVID-19, but their correlations with biomarkers of inflammation, coagulation and endothelial perturbation are still unclear, and no information is available on nailfold histopathology. Nailfold videocapillaroscopy was performed on fifteen patients with COVID-19 in Milan, Italy and the signs of microangiopathy were correlated with plasma biomarkers of inflammation (C reactive protein [CRP], ferritin), coagulation (D-dimer, fibrinogen), endothelial perturbation (Von Willebrand factor [VWF]) and angiogenesis (vascular endothelial growth factor [VEGF]) along with genetic drivers of COVID-19 susceptibility. Histopathological analysis of autoptic nailfold excisions was performed on fifteen patients who died for COVID-19 in New Orleans, …

Anxiety And Agitation In Adult Patients Admitted To An Emergency Room During The Covid-19 Pandemic, Doris L. Asombrado

Dissertations

Purpose: The purpose of this retrospective correlational study was to identify the relationship between COVID-19 status and the prevalence of anxiety-agitation with select sociodemographic and clinical characteristics in adults admitted to the ED during the pandemic (03/01/2020 through 12/31/2020).

Background: COVID-19 infections combined with the WHO and CDC recommendations to mitigate spread have had deleterious psychosocial and economic outcomes with the risk of subsequent COVID-19 related mental illness. Studies indicate one in three adults experience anxiety or depression.

Methods: This retrospective correlational study reviewed 2,572 psychiatric admissions from a Southern California ED during the pandemic from March 1, 2020 through …

Measuring Symptom Burden In Patients With Cancer During A Pandemic: The Md Anderson Symptom Inventory For Covid-19 Mdasi-Covid, Loretta A Williams, Meagan S Whisenant, Tito R Mendoza, Angela E Peek, Donna Malveaux, Donna K Griffin, Darcy A Ponce, Bruno Palma Granwehr, Ajay Sheshadri, Katherine A Hutcheson, Sara M Ali, Susan K Peterson, John V Heymach, Charles S Cleeland, Ishwaria M Subbiah

Faculty, Staff and Student Publications

BACKGROUND: Symptom expression in SARS-CoV-2 infection (COVID-19) may affect patients already symptomatic with cancer. Patient-reported outcomes (PROs) can describe symptom burden during the acute and postacute stages of COVID-19 and support risk stratification for levels of care. At the start of the COVID-19 pandemic, our purpose was to rapidly develop, launch through an electronic patient portal, and provide initial validation for a PRO measure of COVID-19 symptom burden in patients with cancer.

METHODS: We conducted a CDC/WHO web-based scan for COVID-19 symptoms and a relevance review of symptoms by an expert panel of clinicians treating cancer patients with COVID-19 to …

The Longitudinal Analysis Of Convergent Antibody Vdj Regions In Sars-Cov-2-Positive Patients Using Rna-Seq, Kate J Liu, Monika A Zelazowska, Kevin M Mcbride

Faculty, Staff and Student Publications

Severe acute respiratory syndrome-related coronavirus-2 (SARS-CoV-2) is an ongoing pandemic that continues to evolve and reinfect individuals. To understand the convergent antibody responses that evolved over the course of the pandemic, we evaluated the immunoglobulin repertoire of individuals infected by different SARS-CoV-2 variants for similarity between patients. We utilized four public RNA-seq data sets collected between March 2020 and March 2022 from the Gene Expression Omnibus (GEO) in our longitudinal analysis. This covered individuals infected with Alpha and Omicron variants. In total, from 269 SARS-CoV-2-positive patients and 26 negative patients, 629,133 immunoglobulin heavy-chain variable region V(D)J sequences were reconstructed from …

Covid-19 In Casinos: Analysis Of Covid-19 Contamination And Spread With Economic Impact Assessment, Anastasia (Stasi) D. Baran, Jason D. Fiege

International Conference on Gambling & Risk Taking

Abstract:

The COVID-19 pandemic caused tremendous disruption for casinos, with the virus causing various lengths of shutdowns, capacity restrictions, and social distancing strategies such as machine removals or section closures. Although most of the world has now eased off these measures, it is important to review lessons learned to understand, and better prepare for similar circumstances in the future. We present Monte Carlo slot floor simulation software customized to simulate players spreading COVID-19 on the slot floor. We simulate the amount of touch surface contamination; the number of potential surface contact exposure events per day, and a proximity exposures statistic …

Telehealth Fraud And Abuse Before And “After” The Pandemic: Are Things Going To Get Better?, Natalia Shamuel

DePaul Journal of Health Care Law

Telehealth and telemedicine have become increasingly useful to both patients and health care providers. The ease and comfort of attending a doctor’s appointment in the comfort of one’s own home made telehealth and telemedicine convenient, safe, and effective options for seeing a doctor during the height of the COVID-19 pandemic. However, with increased usage of telehealth and telemedicine came increased health care fraud and abuse. With increased health care fraud and abuse came increased regulations, both on the federal and state levels. This Note provides a brief analysis of health care fraud and abuse in the telehealth and telemedicine space. …

Danielle Keeton-Olsen, Oral History Interview, 2023, You Li

Collective Memory of Women Journalists in COVID-19

Danielle Keeton-Olsen is a freelance journalist who explores issues in business, human rights, healthcare, and environmental subjects in Cambodia. She has been stationed in Cambodia since 2017. Her work has been published in Forbes, the BBC, South China Morning Post, VOD English, Al Jazeera, and HuffPost, among others.

In this interview, Keeton-Olsen recalled the ground situation in January 2020 and the COVID impact on local communities and businesses in Cambodia. She reviewed her journey of becoming a foreign correspondent. She commented on the business model of Cambodian media, the media environment, government control of media, media relationship with the general …

Pausing For A Pacemaker: Reversible Sinus Node Dysfunction In A Patient With Acute Sars-Cov-2 Pneumonia, Abdulghani Mounir, Tarek Ajam, Michael Barkett, Jacob Morgan, Mahmoud Ali, Andy Kieu, Mohammed Premjee, Atul Bhatia

Scientific Day

No abstract provided.

Impact Of Atrial Fibrillation On Covid-19 Pneumonia Hospitalizations: Analysis Of The National Inpatient Sample 2020, Mouna Kodali, Ramtej Atluri, Ufuk Vardar, Sami Shoura, Sreeram Yalamanchili, Meghana Vallabhaneni

Scientific Day

No abstract provided.

Stefania D'Ignoti, Oral History Interview, 2023, You Li

Collective Memory of Women Journalists in COVID-19

Stefania D'Ignoti from Catania, Italy, is a freelance journalist who covers migration, conflict, women’s rights, and organized crimes in the broader Mediterranean region. She has reported from Sicily, Turkey, Lebanon, Egypt, the Syrian border, Israel and the Palestinian Territories. Her work has appeared in National Geographic, The Economist, Al Jazeera, The Washington Post, the BBC, the Guardian, and more.

D'Ignoti was forced to shift the reporting focus from the Middle East to Coronavirus in Italy overnight after her flight to Iraq was canceled due to a border lockdown. She mostly covered the impact of COVID-19 on migrants and asylum seekers. …

Impact Of The Covid-19 Pandemic On The Education And Procedural Volume Of Fellows In Critical Care Medicine – A Cross-Sectional Survey, Orlando Garner, Kanta Velamuri, Kristen Staggers, Andrea Barbara Braun

Faculty, Staff and Students Publications

BACKGROUND: The COVID-19 pandemic has changed the way medical education is delivered. The purpose of this study was to assess the impact of the COVID-19 pandemic on the education and procedural volume of critical care and pulmonary critical care fellows.

METHODS: We conducted a cross-sectional, internet-based, voluntary, anonymous, national survey of adult critical care fellows and academic attending physicians in critical care and pulmonary critical care fellowship programs in the United States between December 2020 and February 2021. Survey questions covered both didactic and non-didactic aspects of education and procedural volumes. Answers were ranked on a 5-point Likert scale. Survey …

Cripping And Deafening Covid-19- Re-Framing A Pandemic In Higher Education, Wendy S. Harbour

International Journal on Responsibility

This article looks at ways institutions of higher education (IHEs) can use the models of disability, disability studies, and Deaf studies to “crip” and “Deafen” their response to COVID-19. A review of previous epidemics and pandemics, including yellow fever, the 1918 influenza epidemic, polio, and HIV/AIDS disease, disability, and Deafness. Health services, counseling centers, and disability resource centers expanded over time, and IHEs still rely heavily on them for health, disability, and Deaf concerns. By cripping and Deafening COVID-19 responses, higher education can use a more holistic view of the pandemic, making illness, mental health, disability and Deafness the responsibility …

Megan Clement, Oral History Interview, 2023, You Li

Collective Memory of Women Journalists in COVID-19

Megan Clement from Montreuil, France, is a journalist, critic, and editor whose work focuses on gender equality, social policy, migration, human rights, arts, and culture. Her work has appeared in The Guardian, Bloomberg, The Sydney Morning Herald, Al Jazeera, The New Humanitarian, and News Deeply, among other publications.

Clement, an Australian journalist living in Paris, France at the time, traveled across three continents and underwent four quarantines for work and family reasons during the pandemic. She published her quarantine experiences in the first-person voice and raised public attention to the mismanagement of quarantine protocols at hotels and public housing. She …

University Administrators’ Visions For The Recovery Of International Student Exchange In A Post–Covid-19 World, Yusuke Sakurai, Yukiko Ishikura, Ryoko Nakano, Yuki Nabeshima, Yu Sengoku, Akito Okada, Sachihiko Kondo

Higher Learning Research Communications

Objectives: Little is known about how international functions of higher education, such as exchange programmes, can be resumed during recovery from a disruptive global crisis, such as COVID-19. We collected the opinions of administrators of international exchange programmes regarding their plans to resume their exchange programmes in the recovery phase and identified variations in the responses concerning institution type (public vs. private) and the presence or absence of a medical school.

Method: We used multiple-choice survey questions in our study, resulting in 180 valid responses. We examined overall patterns using descriptive statistics and institutional uniqueness using Fisher’s exact test.

Results: …

Participation Of Academic Libraries And Provision Of Covid-19 Information Services During The Pandemic In Nigeria, Flora Orewa

Library Philosophy and Practice (e-journal)

Information was sought on the level of collaboration between academic libraries and known key players championing the prevention and control of COVID-19, the activities carried out in compliance with set protocols, information services offered, and the challenges faced. Results showed moderate level of collaboration and very limited direct synergistic interaction with public health groups, while they provided patrons with an avenue to source updates from library websites. There was high compliance with COVID-19 prevention guidelines; however, there was no specialized COVID-19 information service desk for patrons' inquiries. Libraries participated in the dissemination of COVID-19 information during the pandemic, especially to …

The Translation Of Inclusion/Acceptance, Accessibility, And Empathy With Online Community Engagement, Jessie C. Feng

VA Engage Journal

Service-learning at Virginia Commonwealth University traditionally involves students performing community service to address community needs, coupled with guided reflection for holistic growth. In the spring of 2020 in-person courses were suspended due to the Covid-19 pandemic, necessitating a transition to online classes. This study aimed to determine if online service-learning provided the same benefits as in-person experiences, focusing on students' perceptions of inclusion/acceptance, empathy, and accessibility. Online surveys were administered to students enrolled in service-learning courses during the semester. Results showed reduced levels of support compared to Fall 2019, but increased social activism and awareness. The study noted that remote …

Out-Of-School Stem Program For Students With Visual Impairments: Adaptations And Outcomes During The Covid-19 Pandemic, Sunggye Hong, Irene Topor, Jinseok Park, Tasnim A. Alshuli, Irene L. Topor

Journal of Science Education for Students with Disabilities

Although previous research exists on making adaptations for students with visual impairments in online settings, there is limited research on the teaching and learning dynamics of students with visual impairments during the COVID-19 pandemic. Since responses to the pandemic made it difficult for students with visual impairments to participate in educational opportunities that require hands-on experiences, gaps have been identified in gaining access to educational opportunities. The current project was originally planned with programs based on in-person modes, aimed at increasing motivation and awareness of science, technology, engineering, and math of students with visual impairments. Due to limitations of in-person …

Donepezil-Associated Survival Benefits Among Alzheimer’S Disease Patients Are Retained But Not Enhanced During Covid-19 Infections, Elizabeth A. Edmiston, Taissa A. Bej, Brigid Wilson, Robin L.P. Jump

Faculty Scholarship

Background and Aim: Donepezil is a front-line treatment for Alzheimer’s disease. Donepezil treatment is associated with decreased risk of all-cause mortality. Specific protection is observed in pneumonia and cardiovascular disease. We hypothesized that donepezil treatment would improve mortality among Alzheimer’s patients following infection with COVID-19. The objective of this study is to assess the influence of ongoing donepezil treatment on survival in Alzheimer’s disease patients after polymerase chain reaction (PCR)-confirmed COVID-19 infection. Methods: This is a retrospective cohort study. We conducted a national survey of Veterans with Alzheimer’s disease to assess the influence of ongoing donepezil treatment on survival in …

Positive Changes In Safety Perception Among Blacks With Hiv And Comorbidities: Assessment Of Social Determinants Of Health During Covid‑19, Marc Fleming, Deidra Lee, Chukwuezugo Oranu, Jon C. Schommer, Jennifer M. Cocohoba, Jennifer Cooper, Crystal K. Hodge, Saharnaz Nedjat, Kathleen Borgmann

Pharmacy Faculty Articles and Research

Purpose

This study aimed to examine the impact of the COVID-19 lockdown on social determinants of health (SDOH) among Blacks with HIV and a comorbid diagnosis of hypertension or type 2 diabetes mellitus (T2DM).

Methods

This was a longitudinal survey study. The inclusion criteria were adults ≥ 18 years and the presence of hypertension and/or diabetes, along with a positive HIV diagnosis. This study enrolled patients in the HIV clinics and chain specialty pharmacies in the Dallas-Fort Worth (DFW) area. A survey of ten questions examining SDOH was conducted before, during, and after the lockdown. A proportional odds mixed effects …

Smoking Status, Nicotine Medication, Vaccination, And Covid-19 Hospital Outcomes: Findings From The Covid Ehr Cohort At The University Of Wisconsin (Cec-Uw) Study, Thomas M Piasecki, Li-Shiun Chen, Et Al.

2020-Current year OA Pubs

INTRODUCTION: Available evidence is mixed concerning associations between smoking status and COVID-19 clinical outcomes. Effects of nicotine replacement therapy (NRT) and vaccination status on COVID-19 outcomes in smokers are unknown.

METHODS: Electronic health record data from 104 590 COVID-19 patients hospitalized February 1, 2020 to September 30, 2021 in 21 U.S. health systems were analyzed to assess associations of smoking status, in-hospital NRT prescription, and vaccination status with in-hospital death and ICU admission.

RESULTS: Current (n = 7764) and never smokers (n = 57 454) did not differ on outcomes after adjustment for age, sex, race, ethnicity, insurance, body mass …

Covid-19 Pandemic: Lived Experiences Of Teachers Supporting Students’ Socialemotional Learning Needs Upon Returning To Face-To-Face Instruction, Valerie Cover

Dissertations

Purpose: The purpose of this qualitative phenomenological study was to explore the lived experiences of San Bernardino County elementary school teachers in supporting students' social-emotional learning needs upon returning to face-to-face instruction after the COVID-19 pandemic.

Methodology: This phenomenological study identified and described San Bernardino County elementary school teachers' experiences supporting students' social-emotional needs upon returning to face-to-face instruction after the COVID-19 pandemic. Participants were purposively chosen based on specific criteria of working in a public kindergarten through sixth grade setting within San Bernardino County. The participants answered 15 semi-structured questions. The transcribed data collected by the researcher during the …

Immigration Policy After Covid-19 And Cultural Resistance At The U.S.-Mexico Border, Grace Ayres-Doyle

Senior Theses

What I examine here is how the global COVID-19 pandemic altered asylum and refugee responsibility among Global North countries. In particular, I look at cultural responses to restrictive pandemic policies which speak to the level of intensity of the current humanitarian crisis at the United States southern border with Mexico. The US-Mexico border functions well as a case study because of its highly publicized and discussed nature, along with the strong influence held by the US over the rest of the world. The cultural moment surrounding Title 42 and other pandemic policies represents a shift in public recognition of the …

Impact Of The Covid-19 Pandemic On Stress And Burnout Related Experiences Of The Infection Preventionists In The Greater Houston Area, Tawanna Mcinnis-Cole

MUSC Theses and Dissertations

Objective: With many studies revealing that the pandemic created stress and burnout for physicians and nurses, these same stressors could have created mental and emotional challenges for the Infection Prevention staff at healthcare institutions. Efforts are needed to better understand the stress, anxiety, and burnout-related experiences that the pandemic created for these team members who worked in the greater Houston area between March 2020-September 2022.

Methods: This qualitative study used focus group sessions to obtain data. Two sessions were held in person and two sessions were hosted virtually. All sessions were audio recorded and transcribed. The transcripts were coded using …

Toll-Like Receptors 2, 4, And 9 Modulate Promoting Effect Of Copd-Like Airway Inflammation On K-Ras-Driven Lung Cancer Through Activation Of The Myd88/Nf-ĸb Pathway In The Airway Epithelium, Walter V Velasco, Nasim Khosravi, Susana Castro-Pando, Nelly Torres-Garza, Maria T Grimaldo, Avantika Krishna, Michael J Clowers, Misha Umer, Sabah Tariq Amir, Diana Del Bosque, Soudabeh Daliri, Maria Miguelina De La Garza, Marco Ramos-Castaneda, Scott E Evans, Seyed Javad Moghaddam

Faculty, Staff and Student Publications

INTRODUCTION: Toll-like receptors (TLRs) are an extensive group of proteins involved in host defense processes that express themselves upon the increased production of endogenous damage-associated molecular patterns (DAMPs) and pathogen-associated molecular patterns (PAMPs) due to the constant contact that airway epithelium may have with pathogenic foreign antigens. We have previously shown that COPD-like airway inflammation induced by exposure to an aerosolized lysate of nontypeable

METHODS: In the present study, we have dissected the role of TLRs in this process by knocking out TLR2, 4, and 9 and analyzing how these deletions affect the promoting effect of COPD-like airway inflammation on …

Balancing The Drinking Act: A Grounded Theory Of Youth Drinking, Policy And Covid-19 In Botswana, Tebogo Sebeelo

The Qualitative Report

Stakeholder and consumer participation is generally seen as a critical part of effective alcohol policy making as it has a direct impact on policy implementation. In the advent of COVID-19, the views and experiences of stakeholders and consumers were integral to how countries responded to the virus. The involvement of alcohol stakeholders and consumers raises critical questions about policy making practices. Using Grounded Theory (GT) methods amongst 20 drinkers and six alcohol stakeholders, I examined the views and experiences of stakeholders and alcohol consumers in Botswana during COVID-19. I identified two interrelated core categories of Balancing the Drinking Act and …