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Barriers And Facilitating Factors For Covid-19 Vaccination In Rural Appalachia, Kathryn M. Cardarelli, Rachel Gillespie, Anna Goodman Hoover, Diane B. Francis, Marc T. Kiviniemi Dec 2025

Barriers And Facilitating Factors For Covid-19 Vaccination In Rural Appalachia, Kathryn M. Cardarelli, Rachel Gillespie, Anna Goodman Hoover, Diane B. Francis, Marc T. Kiviniemi

Epidemiology and Environmental Health Faculty Publications

Background: Since the onset of the pandemic, COVID-19 mortality has disproportionately impacted populations impacted by health inequities. This study aimed to identify the barriers and facilitators to COVID-19 vaccination uptake in Appalachian Kentucky as a first step to developing vaccination interventions. Methods: Key informant interviews were conducted with 36 community leaders in 14 Appalachian Kentucky counties from January-June 2023. Interviews focused on leaders’ perspectives about their community’s COVID-19 experiences, community impacts of the pandemic, and vaccine facilitators and barriers in their communities. Iterative inductive-deductive coding was used to characterize responses. Results: There were barriers and facilitators at multiple levels of …


Sars-Cov-2 Rna-Binding Protein Suppresses Extracellular Mirna Release, Hyejin Mun, Chang Hoon Shin, Qingxuan Fei, Andrea Estefania Lopez Giraldo, Kyoung-Min Choi, Ji Won Lee, Kyungmin Kim, Kyung-Won Min, Leilei Shi, Mark T Bedford, Dong-Chan Kim, Yoo Lim Chun, Seonghyun Ryu, Dongin Kim, Jeong Ho Chang, Ryan T Westrope, Michelle Shay, Edward Nguyen, Junho K Hur, Abigail Agyenda, Nam Chul Kim, Sung-Ung Kang, Woonghee Lee, Je-Hyun Yoon Dec 2025

Sars-Cov-2 Rna-Binding Protein Suppresses Extracellular Mirna Release, Hyejin Mun, Chang Hoon Shin, Qingxuan Fei, Andrea Estefania Lopez Giraldo, Kyoung-Min Choi, Ji Won Lee, Kyungmin Kim, Kyung-Won Min, Leilei Shi, Mark T Bedford, Dong-Chan Kim, Yoo Lim Chun, Seonghyun Ryu, Dongin Kim, Jeong Ho Chang, Ryan T Westrope, Michelle Shay, Edward Nguyen, Junho K Hur, Abigail Agyenda, Nam Chul Kim, Sung-Ung Kang, Woonghee Lee, Je-Hyun Yoon

Faculty, Staff and Student Publications

SARS-CoV-2 is the betacoronavirus causing the COVID-19 pandemic. Although the SARS-CoV-2 genome and transcriptome were reported previously, the function of individual viral proteins is largely unknown. Utilizing biochemical and molecular biology methods, we identified that four SARS-CoV-2 RNA-binding proteins (RBPs) regulate the host RNA metabolism by direct interaction with mature miRNA let-7b revealed by Nuclear Magnetic Resonance spectroscopy (NMR). SARS-CoV-2 RBP Nsp9 primarily binds mature miRNA let-7b, a direct ligand of the Toll-like Receptor 7 (TLR7), one of the potential SARS-CoV-2 therapeutics. Nsp9 suppresses host gene expression possibly by promoting let-7b-mediated silencing of a cellular RNA polymerase, POLR2D. In addition, …


Decoding Fibrosis In Nonresolvable Covid-19: A Role For Myeloid-Specific Hif1a Deletion, Kemly Philip, Hannah P Thompson, Scott D Collum, Isabella Lefebvre, Bindu Akkanti, Bihong Zhao, Rahat Hussain, Manish Patel, Michael R Blackburn, Tingting W Mills, Harry Karmouty-Quintana Dec 2025

Decoding Fibrosis In Nonresolvable Covid-19: A Role For Myeloid-Specific Hif1a Deletion, Kemly Philip, Hannah P Thompson, Scott D Collum, Isabella Lefebvre, Bindu Akkanti, Bihong Zhao, Rahat Hussain, Manish Patel, Michael R Blackburn, Tingting W Mills, Harry Karmouty-Quintana

Faculty, Staff and Student Publications

A complication of viral lung infections is the development of pulmonary fibrosis. This phenomenon is most evident in patients with COVID-19, where in its most aggressive form patients developed nonresolvable (NR) COVID-19 requiring lung transplantation. NR-COVID-19 was characterized by the presentation of a fulminant fibrotic lung injury that progressed rapidly, even in patients with limited comorbidities. However, the mechanisms that led to this rapidly progressing form of fibrosis are not fully understood. A common clinical manifestation in the most severe cases of COVID-19 was the presence of "silent" hypoxemia. Thus, we hypothesized that a dysfunctional hypoxic response may result in …


Long-Term Illness In Adults Hospitalized For Respiratory Syncytial Virus Disease, United States, February 2022-September 2023, Aleda M Leis, Jennie H Kwon, Et Al. Dec 2025

Long-Term Illness In Adults Hospitalized For Respiratory Syncytial Virus Disease, United States, February 2022-September 2023, Aleda M Leis, Jennie H Kwon, Et Al.

2020-Current year OA Pubs

Respiratory syncytial virus (RSV) can cause severe illness, but little is known about long-term consequences in hospitalized adults. We surveyed adults (>18 years of age) who survived hospitalization for RSV or COVID-19 during February 2022-September 2023 about physical functioning and quality of life; surveys were conducted 6-12 months after hospitalization. We compared outcomes after RSV hospitalization by age (< 60 vs. >60 years) and to those hospitalized for COVID-19 by using multivariable regression models. Among 146 adults hospitalized with RSV, 27.4% reported severe breathlessness and 21.9% poor quality of life at follow-up. Few differences were seen in posthospital illness by age. …


Nurses’ And Midwives’ Job Satisfaction And Retention During Covid-19: A Scoping Review, Laura Hynes, Sadie Geraghty, Sheena Mcchlery, Aisling Smyth, Reeti Brar, Karen Clark-Burg Dec 2025

Nurses’ And Midwives’ Job Satisfaction And Retention During Covid-19: A Scoping Review, Laura Hynes, Sadie Geraghty, Sheena Mcchlery, Aisling Smyth, Reeti Brar, Karen Clark-Burg

Research outputs 2022 to 2026

Background: The COVID-19 pandemic focused attention on the previously well-documented world-wide shortage of nurses and midwives. The pandemic accentuated this crisis, which resulted in nurses and midwives questioning their roles and their careers. The impact of the pandemic on job satisfaction and the intention of nurses and midwives to stay has not been adequately explored. Aim: The aim of this scoping review was to identify and map the literature that describes the intrinsic and extrinsic factors that influenced nurses’ and midwives’ job satisfaction and intent to stay or leave their employment or profession during the COVID-19 pandemic. Method: This scoping …


Reflections On Researching Second-Generation Migrant Youths Amidst Covid-19 And Beyond: Challenges And Lessons For Future Researchers, Betty Chiyangwa Nov 2025

Reflections On Researching Second-Generation Migrant Youths Amidst Covid-19 And Beyond: Challenges And Lessons For Future Researchers, Betty Chiyangwa

The Qualitative Report

The COVID-19 pandemic highlighted the need for researchers to adapt to innovative methodologies in qualitative research. I reflect on my doctoral experiences, examining the challenges I faced and lessons I learned during data collection amidst the COVID-19 pandemic and beyond. I explore the hurdles faced, mitigation measures adopted, and lessons for future researchers, using a reflective qualitative design that integrates my personal narrative and thematic analysis. The analysis included a systematic coding process, underpinned by critical narrative inquiry, reflections, observations and an analysis of my field notes. Six hurdles emerged during the data analysis process amidst COVID-19: (1) experiences of …


The Relationship Between Socioecological Factors And Resilience Among Urban Workers During The Covid-19 Pandemic, Puttaporn Onkhamsee, Sukanya Tantiprasoplap,, Wanna Sanongdej Nov 2025

The Relationship Between Socioecological Factors And Resilience Among Urban Workers During The Covid-19 Pandemic, Puttaporn Onkhamsee, Sukanya Tantiprasoplap,, Wanna Sanongdej

Jurnal Keperawatan Indonesia

The global outbreak occasioned by the coronavirus disease 2019 (COVID-19) has affected people of working age in urban communities, both socially and psychologically, making resilience an important aspect of efforts to cope with such a crisis. Against this backdrop, this study identified and investigated the socioecological factors associated with the resilience of employable urban residents against the COVID-19 pandemic as part of a conceptual framework that encompasses individual, family, and community resilience. This cross-sectional research involved 368 working-age individuals recruited via simple randomization from communities in seven areas in central Bangkok. Data were collected through a questionnaire survey and examined …


Clinical Characteristics And Risk Factors Associated With Acute Kidney Injury Among Hospitalized Primary Covid-19 Infected Patients, Monchai Siribamrungwong, Kamontip Chaikomon Nov 2025

Clinical Characteristics And Risk Factors Associated With Acute Kidney Injury Among Hospitalized Primary Covid-19 Infected Patients, Monchai Siribamrungwong, Kamontip Chaikomon

Chulalongkorn Medical Journal

Background: Coronavirus disease 19 (COVID-19) mainly affects to respiratory system from mild to severe symptoms. Additionally, acute kidney injury (AKI) is an important complication causing substantially high morbidity and mortality. During the pandemic of COVID-19, Public health care in Thailand experienced many cases and complications.

Objectives: This study demonstrated an incidence, clinical characteristic, independent risk factors of AKI and mortality in hospitalized COVID-19 patients with AKI and non-AKI patients.

Methods: A retrospective, observational study was performed in Lesdsin Hospital from August 2021 to August 2022. A total of 576 hospitalized patients with diagnosis of COVID-19 infection were analyzed. AKI was …


How Not To Go Viral? A Covid-19 Handbook For Students Nov 2025

How Not To Go Viral? A Covid-19 Handbook For Students

University press releases and calendars

No abstract provided.


Serum Levels Of Uchl1 And S100b In Covid-19 And Multiple Sclerosis Patients: A Comparative Study In Erbil City, Krg, Iraq, Daldar Fares Jeejo, Mayada Noori Iqbal, Nisreen Sherif Alyasiri Nov 2025

Serum Levels Of Uchl1 And S100b In Covid-19 And Multiple Sclerosis Patients: A Comparative Study In Erbil City, Krg, Iraq, Daldar Fares Jeejo, Mayada Noori Iqbal, Nisreen Sherif Alyasiri

Baghdad Science Journal

Ubiquitin carboxyl-terminal hydrolase L1 (UCHL1) and S100B are proteins involved in neuronal development and damage. Their levels in serum have been proposed as potential biomarkers for various neurological conditions, including COVID-19 and Multiple Sclerosis (MS). The study aimed to compare serum levels of UCHL1 and S100B among COVID-19 patients, MS patients, and healthy controls, and to assess the correlation between these biomarkers in the context of COVID-19. This cross-sectional study included 91 COVID-19 patients, 29 MS patients, and 50 healthy controls from the Kurdistan Region (KRG) of Iraq. Serum levels of UCHL1 and S100B were quantified using enzyme-linked immunosorbent assay …


Experiences Of College Students With Visual Disabilities During The Covid-19, Bhuwan Shankar Bhatt, Kanchan K. Joshi, Purna B. Lamichhane Nov 2025

Experiences Of College Students With Visual Disabilities During The Covid-19, Bhuwan Shankar Bhatt, Kanchan K. Joshi, Purna B. Lamichhane

Journal of Comparative & International Higher Education

This case study explores the experiences of Nepalese college students with visual disabilities during the COVID-19 pandemic, applying Bronfenbrenner’s Ecological Systems Theory as a theoretical framework. Through in-depth interviews with eight students with visual disabilities studying bachelor and master level at a public college, this research describes challenges and chances across five primary domains of the ecological perspective. The study showed the critical role of immediate support circles in academic and social contexts, the needed interactions between parents and educational institutions, observable gaps in institutional support and government policies, and the dual role of the pandemic as a challenge and …


What Covid-19 Taught Extension: Experiences Of Extension County Engagement Specialists Promoting Vaccinations In Meat Processing Plants In Rural Missouri., Wilson Majee, Ifeolu David, Lynelle Phillips, Rachel Buenemann, Kassandra Maturino Nov 2025

What Covid-19 Taught Extension: Experiences Of Extension County Engagement Specialists Promoting Vaccinations In Meat Processing Plants In Rural Missouri., Wilson Majee, Ifeolu David, Lynelle Phillips, Rachel Buenemann, Kassandra Maturino

Journal of Extension

Extension played a significant role, in collaboration with other key community organizations, by disseminating information that debunked COVID-19 myths, and promoting vaccinations at the community level. In this article we present insights from the experiences of Extension faculty at the University of Missouri who were engaged in promoting COVID-19 vaccinations for meat processing plant workers. Findings from this quality improvement project highlight opportunities for leveraging Extension field faculty, and challenges to consider in future public health promotion efforts.


Estimated Impact Of 2022–2023 Influenza Vaccines On Annual Hospital Burden In The United States, Kaiming Bi, Shraddha Ramdas Bandekar, Anass Bouchnita, Annalise Cramer, Spencer J Fox, Rebecca K Borchering, Matthew Biggerstaff, Lauren Ancel Meyers Nov 2025

Estimated Impact Of 2022–2023 Influenza Vaccines On Annual Hospital Burden In The United States, Kaiming Bi, Shraddha Ramdas Bandekar, Anass Bouchnita, Annalise Cramer, Spencer J Fox, Rebecca K Borchering, Matthew Biggerstaff, Lauren Ancel Meyers

Faculty, Staff and Student Publications

During the COVID-19 pandemic early years, infection prevention measures suppressed transmission of seasonal influenza and other respiratory viruses. The early onset and moderate severity of the US 2022-2023 influenza season may have resulted from reduced use of nonpharmaceutical interventions or lower population immunity after 2 y of limited influenza virus circulation. We used a mathematical model of influenza virus transmission that incorporates vaccine-derived protection against both infection and severe disease to estimate the impact of influenza vaccines on healthcare burden. Assuming reported levels of past vaccine effectiveness (VE) against infection and hospitalization, we estimate that influenza vaccines prevented 69,886 (95% …


Utilization Of Antiviral Treatment For Hospitalized Patients With Mild-To-Moderate Covid-19 At High Risk For Disease Progression, Michael P. Iannetti, Katie Barnes, Stephen Varga, Suzanne Kemper, Elaine Davis Mattox Nov 2025

Utilization Of Antiviral Treatment For Hospitalized Patients With Mild-To-Moderate Covid-19 At High Risk For Disease Progression, Michael P. Iannetti, Katie Barnes, Stephen Varga, Suzanne Kemper, Elaine Davis Mattox

Journal of Community Hospital Internal Medicine Perspectives

Clinicians frequently encounter patients in the hospital with mild-to-moderate COVID-19 who are at high risk for disease progression. Antiviral drugs reduce the rate of progression to severe COVID-19 when given to these patients within 5-7 days of symptom onset. To look at the utilization of antiviral medications in hospitalized patients with mild-to-moderate COVID-19, a detailed chart review was conducted of 500 randomly selected patients from the Charleston Area Medical Center COVID-19 Registry. We identified 124 patients with mild-to-moderate COVID-19 who were eligible for antiviral treatment. Only 41 of the 124 patients (33.1%) received antiviral treatment. Providers listed mild symptoms as …


State-Level Progress And Setbacks In Influenza Vaccination Among Adults ≥65: A Fifteen-Season Analysis From 2009/10 To 2023/24, Luigi Russo, Sara Farina, Raffaele Angelo Macri, William Alan Pentecost, Alessandra Maio, Leonardo Villani, Vittorio Maio, Stefania Boccia, Walter Ricciardi Nov 2025

State-Level Progress And Setbacks In Influenza Vaccination Among Adults ≥65: A Fifteen-Season Analysis From 2009/10 To 2023/24, Luigi Russo, Sara Farina, Raffaele Angelo Macri, William Alan Pentecost, Alessandra Maio, Leonardo Villani, Vittorio Maio, Stefania Boccia, Walter Ricciardi

College of Population Health Faculty Papers

INTRODUCTION: Influenza is a contagious respiratory infection with substantial health and economic consequences worldwide. Annual vaccination is the most effective preventive strategy; however, coverage among older adults remains suboptimal and varies considerably across the United States. This study aimed to examine state-level trends in influenza vaccination coverage among adults aged ≥65 years across fifteen influenza seasons (2009/10-2023/24).

METHODS: State-level vaccination coverage data for adults aged ≥65 years were obtained from the CDC FluVaxView platform, which reports annual estimates by influenza season. The analysis covered the 2009/10 through 2023/24 influenza seasons. Joinpoint regression was used to assess temporal trends and estimate …


Analyzing Discipline Rates For Students In Grades 6-12 With Emotional Disturbances: A Comparative Study Of Four Years Before And After The Covid-19 Pandemic., Maegan N. Ramsey Nov 2025

Analyzing Discipline Rates For Students In Grades 6-12 With Emotional Disturbances: A Comparative Study Of Four Years Before And After The Covid-19 Pandemic., Maegan N. Ramsey

Doctoral Dissertations and Projects

This dissertation investigated the trends in discipline rates for students in grades 6-12 with emotional disturbances. It compared data from the four years prior to the COVID-19 pandemic (2016-2019) to the four years following its onset (2021-2024). Emotional disturbances can significantly affect students' behavior, often leading to higher rates of disciplinary actions within school settings. However, the impact of COVID-19 on these students, particularly in terms of remote learning, school closures, and shifts in behavioral norms, has yet to be fully explored. Using archival data from multiple middle and high schools, this study examined variations in suspensions and other disciplinary …


Grief Disrupted: A Phenomenological Study Of How African Americans Experienced Grief Without Traditional Rituals During The Covid-19 Pandemic, Jacqueline Williamson-Webb Nov 2025

Grief Disrupted: A Phenomenological Study Of How African Americans Experienced Grief Without Traditional Rituals During The Covid-19 Pandemic, Jacqueline Williamson-Webb

Doctoral Dissertations and Projects

In recent times, the dominant psychological understanding of grief is as an emotion (Gravesen & Birkelund, 2021; Meiselman, 2021). However, grief is also socially constructed, meaning that the emotions and behaviors labeled as grief have their beginning in the social space. Grief, then, is a performative act shaped by cultural traditions and public rituals (Murrell et al., 2023). Consequently, the purpose of this interpretative phenomenological study is to understand the lived grief experiences of African Americans (AAs) living in New Jersey who experienced a personal loss through the death of another person during the COVID-19 pandemic. Erving Goffman’s dramaturgy guides …


Social Determinants Of Health Patterns In Children With Severe Disease Due To Sars-Cov-2 Infection-An Exploratory Approach, Joshua Prabhu, Sebastian Acosta, Fabio Savorgnan, Ananth V Annapragada, Usha Sethuraman Nov 2025

Social Determinants Of Health Patterns In Children With Severe Disease Due To Sars-Cov-2 Infection-An Exploratory Approach, Joshua Prabhu, Sebastian Acosta, Fabio Savorgnan, Ananth V Annapragada, Usha Sethuraman

Faculty, Staff and Students Publications

Background/Objectives: Research on the association of adverse social determinants of health (SDOH) with severe pediatric coronavirus disease (COVID-19) is limited. We examined associations between SDOH patterns and COVID-19 severity in children.

Methods: We conducted a prospective, observational study of children (< 18 years) with symptomatic SARS-CoV-2 infection evaluated in an urban pediatric emergency department (March 2021-April 2022) in Detroit, Michigan. Caregivers completed a 34-item survey based on the Healthy People 2030 framework. Severe disease was defined as the occurrence of respiratory/cardiac failure or death within four weeks of diagnosis. Continuous and categorical variables were described using medians and percentages, respectively. Associations between disease severity and risk factors were determined using chi-square tests. Association rule mining was used for feature selection, followed by multivariate logistic regression.

Results: We analyzed data from 354 children [6-12 years: 31.1%, Female: 51.1%, Black: 59%, not Hispanic: 84.7%, public insurance: 77.1%, chronic condition: 27.4%]. Of the total, 113 children had severe disease. Most caregivers were 30-44 years old (53.1%), had less than a college degree (70.4%), and income < USD 50,000 (75.2%). Adverse SDOH reported included food/housing insecurity (24.6%), no support (64.7%), unmet childcare needs (35.9%), and lack of transportation (12.7%). After controlling for age, sex, medical history, income, and obesity, severe disease was associated with caregiver use of drugs/alcohol (OR:5.92, p < 0.001) and social discrimination/lack of support (OR: 1.74, p = 0.030).

Conclusions: Two SDOH patterns (caregiver use of drugs/alcohol …


Impact Of Frailty On Inpatient Outcomes Of Covid-19 Patients: Evidence From A Us National Inpatient Sample, Ali Jaan, Priyanshi Shah, Ashish Dhawan, Saria Qaiser, Azka Ali, Hla Myo Thwe, Oluwatosin Abimbolu, Clara Chimuanya Okpara, Michael Rajnik Nov 2025

Impact Of Frailty On Inpatient Outcomes Of Covid-19 Patients: Evidence From A Us National Inpatient Sample, Ali Jaan, Priyanshi Shah, Ashish Dhawan, Saria Qaiser, Azka Ali, Hla Myo Thwe, Oluwatosin Abimbolu, Clara Chimuanya Okpara, Michael Rajnik

Advances in Clinical Medical Research and Healthcare Delivery

Introduction: The global impact of Coronavirus Disease 2019 (COVID-19), caused by severe-acute-respiratory-syndrome coronavirus 2 (SARS-CoV-2), has been profound, claiming the lives of more than 3 million individuals within a year and a half. Among the affected population, heightened vulnerability is observed among older and frailer individuals, leading to more severe symptoms and adverse outcomes compared to their younger, non-frail counterparts. This study to analyze the impact of frailty on the outcomes of adult patients admitted with COVID-19.

Methods: Using the National Inpatient Sample (NIS) database 2020, we identified adult patients admitted with a principal diagnosis of COVID-19. The …


The Impact Of Npo Credibility On Enterprise Brand Image In Cause-Related Marketing: A Study Based On The Mediating Effect Of Perceived Corporate Hypocrisy, Jun Wang, Ling Zheng, Xinyi Li, Chiquan Guo Nov 2025

The Impact Of Npo Credibility On Enterprise Brand Image In Cause-Related Marketing: A Study Based On The Mediating Effect Of Perceived Corporate Hypocrisy, Jun Wang, Ling Zheng, Xinyi Li, Chiquan Guo

Marketing Faculty Publications

In recent years, scandals regarding the malpractices of many nonprofit organizations (NPOs) for selfish ends have eroded public trust in them. Therefore, it is necessary to consider whether the credibility of NPOs, as one of the three key implementers in cause-related marketing (CRM) campaigns, has a transfer effect on enterprise brand image. The aim of the current study is to examine the relationship between NPO credibility and enterprise brand image, along with its underlying mechanism and boundary conditions. Drawing on the affect-transfer model as well as attribution theory, we propose a theoretical model. This model highlights the mediating role of …


A Multiomics Recovery Factor Predicts Long Covid In The Impacc Study, Gisela Gabernet, Jessica Maciuch, Jeremy P Gygi, John F Moore, Annmarie Hoch, Caitlin Syphurs, Tianyi Chu, Naresh Doni Jayavelu, David B Corry, Farrah Kheradmand, Lindsey R Baden, Rafick-Pierre Sekaly, Grace A Mccomsey, Elias K Haddad, Charles B Cairns, Nadine Rouphael, Ana Fernandez-Sesma, Viviana Simon, Jordan P Metcalf, Nelson I Agudelo Higuita, Catherine L Hough, William B Messer, Mark M Davis, Kari C Nadeau, Bali Pulendran, Monica Kraft, Chris Bime, Elaine F Reed, Joanna Schaenman, David J Erle, Carolyn S Calfee, Mark A Atkinson, Scott C Brakenridge, Esther Melamed, Albert C Shaw, David A Hafler, Alison D Augustine, Patrice M Becker, Al Ozonoff, Steven E Bosinger, Walter Eckalbar, Holden T Maecker, Seunghee Kim-Schulze, Hanno Steen, Florian Krammer, Kerstin Westendorf, Bjoern Peters, Slim Fourati, Matthew C Altman, Ofer Levy, Kinga K Smolen, Ruth R Montgomery, Joann Diray-Arce, Steven H Kleinstein, Leying Guan, Lauren Ir Ehrlich Nov 2025

A Multiomics Recovery Factor Predicts Long Covid In The Impacc Study, Gisela Gabernet, Jessica Maciuch, Jeremy P Gygi, John F Moore, Annmarie Hoch, Caitlin Syphurs, Tianyi Chu, Naresh Doni Jayavelu, David B Corry, Farrah Kheradmand, Lindsey R Baden, Rafick-Pierre Sekaly, Grace A Mccomsey, Elias K Haddad, Charles B Cairns, Nadine Rouphael, Ana Fernandez-Sesma, Viviana Simon, Jordan P Metcalf, Nelson I Agudelo Higuita, Catherine L Hough, William B Messer, Mark M Davis, Kari C Nadeau, Bali Pulendran, Monica Kraft, Chris Bime, Elaine F Reed, Joanna Schaenman, David J Erle, Carolyn S Calfee, Mark A Atkinson, Scott C Brakenridge, Esther Melamed, Albert C Shaw, David A Hafler, Alison D Augustine, Patrice M Becker, Al Ozonoff, Steven E Bosinger, Walter Eckalbar, Holden T Maecker, Seunghee Kim-Schulze, Hanno Steen, Florian Krammer, Kerstin Westendorf, Bjoern Peters, Slim Fourati, Matthew C Altman, Ofer Levy, Kinga K Smolen, Ruth R Montgomery, Joann Diray-Arce, Steven H Kleinstein, Leying Guan, Lauren Ir Ehrlich

Faculty, Staff and Students Publications

Background: Following SARS-CoV-2 infection, approximately 10%–35% of patients with COVID-19 experience long COVID (LC), in which debilitating symptoms persist for at least 3 months. Elucidating the biologic underpinnings of LC could identify therapeutic opportunities.

Methods: We utilized machine learning methods on biologic analytes provided over 12 months after hospital discharge from more than 500 patients with COVID-19 in the IMPACC cohort to identify a multiomics “recovery factor,” trained on patient-reported physical function survey scores. Immune profiling data included PBMC transcriptomics, serum O-link and plasma proteomics, plasma metabolomics, and blood mass cytometry by time of flight (CyTOF) protein levels. Recovery factor …


Remaking The Smart City Through The Covid-19 Pandemic: Seoul, Singapore, Taipei, Orlando Woods, I-Chun Catherine Chang, Haeran Shin Nov 2025

Remaking The Smart City Through The Covid-19 Pandemic: Seoul, Singapore, Taipei, Orlando Woods, I-Chun Catherine Chang, Haeran Shin

Research Collection College of Integrative Studies

The COVID-19 pandemic has proven to be a catalysing force for urban innovation in general, and for smart city agendas specifically, throughout the world. From the development of contact tracing technologies and the enforcement of quarantine and safe distancing measures, to the dissemination of public health information and advancement of telehealth rollouts, the promises of “smart” technologies to reveal and govern patterns of socio-spatial contact and mobility can be found at the core of effective city management during the pandemic. Arguably nowhere is this truer than in the cities of Seoul, Singapore and Taipei, where the Asian developmental state was …


Sars-Cov-2 Mrna Vaccines Sensitize Tumours To Immune Checkpoint Blockade, Adam J Grippin, Christiano Marconi, Sage Copling, Nan Li, Chen Braun, Cole Woody, Elliana Young, Priti Gupta, Min Wang, Annette Wu, Seong Dong Jeong, Dhruvkumar Soni, Frances Weidert, Chao Xie, Eden Goldenberg, Andrew Kim, Chong Zhao, Anna Devries, Paul Castillo, Rishabh Lohray, Michael K Rooney, Benjamin R Schrank, Yifan Wang, Yifan Ma, Enoch Chang, Ramez Kouzy, Kyle Dyson, Jordan Jafarnia, Nina Nariman, Gregory Gladish, Jacob New, Ada Argueta, Diana Amaya, Nagheme Thomas, Andria Doty, Joe Chen, Nikhil Copling, Gabriel Alatrash, Julie Simon, Alicia Bea Davies, William Dennis, Richard Liang, Jeff Lewis, Xiong Wei, Waree Rinsurongkawong, Ara A Vaporciyan, Andrew Johns, D3code Team, Jack Lee, Ji-Hyun Lee, Ryan Sun, Padmanee Sharma, Hai Tran, Jianjun Zhang, Don L Gibbons, Jennifer Wargo, Betty Y S Kim, John V Heymach, Hector R Mendez-Gomez, Wen Jiang, Elias J Sayour, Steven H Lin Nov 2025

Sars-Cov-2 Mrna Vaccines Sensitize Tumours To Immune Checkpoint Blockade, Adam J Grippin, Christiano Marconi, Sage Copling, Nan Li, Chen Braun, Cole Woody, Elliana Young, Priti Gupta, Min Wang, Annette Wu, Seong Dong Jeong, Dhruvkumar Soni, Frances Weidert, Chao Xie, Eden Goldenberg, Andrew Kim, Chong Zhao, Anna Devries, Paul Castillo, Rishabh Lohray, Michael K Rooney, Benjamin R Schrank, Yifan Wang, Yifan Ma, Enoch Chang, Ramez Kouzy, Kyle Dyson, Jordan Jafarnia, Nina Nariman, Gregory Gladish, Jacob New, Ada Argueta, Diana Amaya, Nagheme Thomas, Andria Doty, Joe Chen, Nikhil Copling, Gabriel Alatrash, Julie Simon, Alicia Bea Davies, William Dennis, Richard Liang, Jeff Lewis, Xiong Wei, Waree Rinsurongkawong, Ara A Vaporciyan, Andrew Johns, D3code Team, Jack Lee, Ji-Hyun Lee, Ryan Sun, Padmanee Sharma, Hai Tran, Jianjun Zhang, Don L Gibbons, Jennifer Wargo, Betty Y S Kim, John V Heymach, Hector R Mendez-Gomez, Wen Jiang, Elias J Sayour, Steven H Lin

Faculty, Staff and Student Publications

Immune checkpoint inhibitors (ICIs) extend survival in many patients with cancer but are ineffective in patients without pre-existing immunity19. Although personalized mRNA cancer vaccines sensitize tumours to ICIs by directing immune attacks against preselected antigens, personalized vaccines are limited by complex and time-intensive manufacturing processes1014. Here we show that mRNA vaccines targeting SARS-CoV-2 also sensitize tumours to ICIs. In preclinical models, SARS-CoV-2 mRNA vaccines led to a substantial increase in type I interferon, enabling innate immune cells to prime CD8+ T cells that target tumour-associated antigens. Concomitant ICI treatment is required for …


Comparing In-Person And Remote Consent Of People With Dementia Into A Primary Care-Based Cluster Randomised Controlled Trial: Lessons From The Dementia Personalised Care Team (D-Pact) Feasibility Study, T. M. Oh, S. Batool, C. Musicha, L. Greene, H. Wheat, L. Smith, S. Griffiths, A. Gude, L. Weston, H. Shafi, K. Stevens, C. Sutcliffe, W. Taylor, W. Ingram, B. Hussain, P. Clarkson, I. Sherriff, O. C. Ukoumunne, S. Creanor, R. Byng Oct 2025

Comparing In-Person And Remote Consent Of People With Dementia Into A Primary Care-Based Cluster Randomised Controlled Trial: Lessons From The Dementia Personalised Care Team (D-Pact) Feasibility Study, T. M. Oh, S. Batool, C. Musicha, L. Greene, H. Wheat, L. Smith, S. Griffiths, A. Gude, L. Weston, H. Shafi, K. Stevens, C. Sutcliffe, W. Taylor, W. Ingram, B. Hussain, P. Clarkson, I. Sherriff, O. C. Ukoumunne, S. Creanor, R. Byng

Peninsula Medical School

Background: Complex socio-cultural, psychological, geographical, and service-related challenges are faced when recruiting people with dementia for clinical trials. The aim of Phase 1 of the Dementia PersonAlised Care Team (D-PACT) project was to assess the feasibility of recruiting (identifying, approaching and consenting) people with dementia, including those without capacity to consent, to a cluster randomized controlled trial of a primary care-based personalized dementia support intervention in England. COVID-19 necessitated a shift to remote working, creating the opportunity to compare recruitment strategies before and under lockdown constraints. This paper shares the adaptations made to enable remote consent and capacity judgement with …


The Challenge Of Domestic Violence In The Balkan States, Marigona Bajraktaraj, Florent Azemi Oct 2025

The Challenge Of Domestic Violence In The Balkan States, Marigona Bajraktaraj, Florent Azemi

UBT International Conference

Domestic violence is a major social problem that includes physical, sexual, emotional, economic, and psychological forms.It appears as a repeated pattern of behavior aimed at control and domination over the partner, affecting the lives of all family members.The main characteristics are the abuse of power and the violation of the victim’s fundamental rights. The consequences manifest in pain, suffering, and the undermining of the victim’s health and safety.Many victims remain in abusive relationships due to fear and threats of harm.Balkan states have criminalized domestic violence and established penalties for offenders. The phenomenon is also linked to femicide and has worsened …


Labor Rights And Financial Implications For Smes In Kosovo During The Covid-19 Pandemic, Arbnor Hajdari, Bekim Syla Oct 2025

Labor Rights And Financial Implications For Smes In Kosovo During The Covid-19 Pandemic, Arbnor Hajdari, Bekim Syla

UBT International Conference

The COVID-19 pandemic posed unprecedented challenges for developing economies, fundamentally testing the resilience of labor market structures and the adaptability of the workforce. In Kosovo, small and medium-sized enterprises (SMEs), which represent the cornerstone of the national economy, were disproportionately impacted by stringent public health restrictions, limited access to finance, and persistent uncertainty This study seeks to provide a comprehensive analysis of the extent to which labor rights and social protection mechanisms were exercised during the pandemic, as well as to assess the broader financial and socio-economic implications for SMEs. The findings indicate pervasive informality in employment relations, coupled with …


Acute Mastoiditis In Children During The Covid Era: A Systematic Review And Meta-Analysis, Erin Briggs, Isabelle J. Chau, Shaun A. Nguyen, Justin C. Pelic, Erin A. Harvey, Ted A. Meyer Oct 2025

Acute Mastoiditis In Children During The Covid Era: A Systematic Review And Meta-Analysis, Erin Briggs, Isabelle J. Chau, Shaun A. Nguyen, Justin C. Pelic, Erin A. Harvey, Ted A. Meyer

SKMC Student Presentations and Publications

OBJECTIVE: Explore the impact of the COVID-19 pandemic on pediatric acute mastoiditis (AM).

DATA SOURCES: CINAHL, Cochrane Library, PubMed, Scopus.

METHODS: Literature was searched from 2014 to 2025 for articles reporting AM in children. Specific outcomes included clinical presentation, bacterial epidemiology, complications, and management. Primary outcome measures included continuous measures (mean), proportions (%), mean difference (Δ), and relative risk (RR) with 95 % confidence intervals (CI).

RESULTS: There were seven included studies (N = 1001 children) with 632 patients in the pre-COVID cohort and 369 in the COVID-era cohort. There was a significant difference in the proportion of intracranial complications …


University Students’ Condom Use During The Covid-19 Pandemic: Cross-Cultural Differences And What Predict Them, Liam Dacosta, James S. Morandini, Rebecca T. Pinkus, Elien De Caluwé, Lik Sam Chan, Olivine Lo, Saowanee Thongnopakun, Sawitree Visanuyothin, Cheryl Harasymchuk, Samantha Joel, Helen C. Harton, Alyssa Mccoy, Victoria Dale, David L. Rodrigues, Judit Takács, Alexandra Sipos, Veronica M. Lamarche, Racidon Bernarte, Viktorija Čepukienė, Ivana M. Jakšić, Bojana Bodroža, Huỳnh Hồng Mai, Tran Thi Hong, Grace Akello, Ivana Hromatko, Asha Ganesan, Jiawei Zhang, Damian Murray, James Moran, Juan Ramón Barrada, Ángel Castro, Claudia Navarro-Roldan, Kuan-Pin Su, Jane Chang, Matthew B. Ruby, Donya Ziadlou, Shin Nakamine, Yutaka Watanabe, Albert Lee, Richelle-Joy Chia, Ilan Dar-Nimrod Oct 2025

University Students’ Condom Use During The Covid-19 Pandemic: Cross-Cultural Differences And What Predict Them, Liam Dacosta, James S. Morandini, Rebecca T. Pinkus, Elien De Caluwé, Lik Sam Chan, Olivine Lo, Saowanee Thongnopakun, Sawitree Visanuyothin, Cheryl Harasymchuk, Samantha Joel, Helen C. Harton, Alyssa Mccoy, Victoria Dale, David L. Rodrigues, Judit Takács, Alexandra Sipos, Veronica M. Lamarche, Racidon Bernarte, Viktorija Čepukienė, Ivana M. Jakšić, Bojana Bodroža, Huỳnh Hồng Mai, Tran Thi Hong, Grace Akello, Ivana Hromatko, Asha Ganesan, Jiawei Zhang, Damian Murray, James Moran, Juan Ramón Barrada, Ángel Castro, Claudia Navarro-Roldan, Kuan-Pin Su, Jane Chang, Matthew B. Ruby, Donya Ziadlou, Shin Nakamine, Yutaka Watanabe, Albert Lee, Richelle-Joy Chia, Ilan Dar-Nimrod

Faculty Publications

Humans instinctively adopt methods to reduce their risk of encountering harmful pathogens, yet their adherence to preventive health practices can often be erratic. Condoms exemplify one vital preventive tool against sexually transmitted infections (STIs) that, despite their effectiveness, are not consistently utilized. This pattern of behavior appears to persist even during periods of widespread disease transmission, with varied data from the COVID-19 pandemic indicating that condom usage remained inconsistent. The present study aimed to clarify these inconsistencies by examining changes in condom use cross-culturally. Heterosexual participants who were sexually active (N = 3,972 [1,327 men, 2,645 women], Mage= 22.82) across …


Decision-Making During A Crisis: A Case Study Of How A University Responded To The Covid-19 Pandemic, Ryan Joseph Iocco Oct 2025

Decision-Making During A Crisis: A Case Study Of How A University Responded To The Covid-19 Pandemic, Ryan Joseph Iocco

Electronic Theses and Dissertations

Scant research is available on how university leaders make decisions and communicate those decisions to their stakeholders during times of crisis. The purpose of this case study was to better understand the decision-making process used by administrative leaders at a higher education institution during a time of organizational crisis. This study examined decision-making by higher education leaders within and across different functional areas at a single higher education institution between February 2020 and September 2020, following the onset of the COVID-19 pandemic. Data was collected through interviews and document analysis. Although research exists on decision-making during crises, there is limited …


Posttraumatic Growth Experienced By Us Nurses: A National Study, Linda H. Yoder, Jacqueline M. Gordon, Noah R. Zanville Oct 2025

Posttraumatic Growth Experienced By Us Nurses: A National Study, Linda H. Yoder, Jacqueline M. Gordon, Noah R. Zanville

Creating Healthy Work Environments (CHWE)

Post-traumatic growth (PTG) experienced by US nurses who provided care during the COVID-19 pandemic has not been examined. The findings from this multisite study of over 2,000 nurses provide information about the various factors of PTG that were experienced. Recommendations to promote PTG among nurses will be provided.

Detailed abstract attached.