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In Silico Drug Repositioning Against Human Nrp1 To Block Sars-Cov-2 Host Entry, Şeref Gül

Turkish Journal of Biology

Despite COVID-19 turned into a pandemic, no approved drug for the treatment or globally available vaccine is out yet. In such a global emergency, drug repurposing approach that bypasses a costly and long-time demanding drug discovery process is an effective way in search of finding drugs for the COVID-19 treatment. Recent studies showed that SARS-CoV-2 uses neuropilin-1 (NRP1) for host entry. Here we took advantage of structural information of the NRP1 in complex with C-terminal of spike (S) protein of SARSCoV- 2 to identify drugs that may inhibit NRP1 and S protein interaction. U.S. Food and Drug Administration (FDA) approved …

The Current State Of Validated Small Molecules Inhibiting Sars-Cov-2 Non-Structural Proteins, Fati̇h Kocabaş, Merve Uslu

Turkish Journal of Biology

The current COVID-19 outbreak has had a profound influence on public health and daily life. Despite all restrictions and vaccination programs, COVID-19 still can lead to fatality due to a lack of COVID-19-specific treatments. A number of studies have demonstrated the feasibility to develop therapeutics by targeting underlying components of the viral proteome. Here we reviewed recently developed and validated small molecule inhibitors of SARS-CoV-2's nonstructural proteins. We described the validation level of identified compounds specific for SARS-CoV-2 in the presence of in vitro and in vivo supporting data. The mechanisms of pharmacological activity, as well as approaches for developing …

Coronavac (Sinovac) Covid-19 Vaccine-Induced Molecular Changes In Healthy Human Serum By Infrared Spectroscopy Coupled With Chemometrics, Ayça Doğan Mollaoğlu, Rafi̇g Gurbanov, Mete Severcan, Feri̇de Severcan

Turkish Journal of Biology

From the beginning of the COVID-19 coronavirus pandemic in December of 2019, the disease has infected millions of people worldwide and caused hundreds of thousands of deaths. Since then, several vaccines have been developed. One of those vaccines is inactivated CoronaVac-Sinovac COVID-19 vaccine. In this proof of concept study, we first aimed to determine CoronaVac-induced biomolecular changes in healthy human serum using infrared spectroscopy. Our second aim was to see whether the vaccinated group can be separated or not from the non-vaccinated group by applying chemometric techniques to spectral data. The results revealed that the vaccine administration induced significant changes …

Covid-19 And The Caregiving Crisis: The Rights Of Our Nation's Social Safety Net And A Doorway To Reform, Leanne Fuith, Susan Trombley

Faculty Scholarship

In March 2020, the United States declared a pandemic due to the global Covid-19 virus. Across the nation and within a matter of days, workplaces, schools, childcare, and eldercare facilities shuttered. People retreated to their homes to shelter-in-place and slow the spread of the virus for what would become a much longer time than most initially anticipated. Now, more than a year into the pandemic, many professional and personal lives have been upended and become inextricably intertwined. Work is now home, and home is now work. Work is completed at all times of day and well into the night. Children …

Overlapping But Disparate Inflammatory And Immunosuppressive Responses To Sars-Cov-2 And Bacterial Sepsis: An Immunological Time Course Analysis, Tyler J Loftus, Ricardo Ungaro, Marvin Dirain, Philip A Efron, Monty B Mazer, Kenneth E Remy, Richard S Hotchkiss, Luer Zhong, Rhonda Bacher, Petr Starostik, Lyle L Moldawer, Scott C Brakenridge

Open Access Publications

Both severe SARS-CoV-2 infections and bacterial sepsis exhibit an immunological dyscrasia and propensity for secondary infections. The nature of the immunological dyscrasias for these differing etiologies and their time course remain unclear. In this study, thirty hospitalized patients with SARS-CoV-2 infection were compared with ten critically ill patients with bacterial sepsis over 21 days, as well as ten healthy control subjects. Blood was sampled between days 1 and 21 after admission for targeted plasma biomarker analysis, cellular phenotyping, and leukocyte functional analysis

Covid-19’S Impact On Human Trafficking: The Invisible Industry In New Hampshire, Brittany Dunkle

Honors Theses and Capstones

Human trafficking is a modern-day form of slavery that operates on the premise of exploitation, such as forced prostitution and labor, and organ trafficking. This is a global industry resulting in billions. Despite the current global pandemic, COVID-19, putting a halt to many livelihoods around the world, human trafficking will persist, but in conditions that are potentially more harmful for the victims. Victims of trafficking are in an increasingly vulnerable position, and it is important to establish possible mechanisms to protect as many victims and potential victims as possible. Typical risk factors (i.e., poverty, state’s interest vs. individual interest, unemployment) …

Influence Of Political Affiliation On Perceived Media Bias And Trustworthiness In The Covid-19 Pandemic, Tabitha Lamberth

College of Graduate Studies: Theses & Dissertations

Partisanship and news source attribution may influence perceived media bias and trust in COVID-19 information. This study aimed to explore how the similarity liking effect relates to political identity and perceived credibility. Our main hypothesis was that individuals would find news sources that shared their political affiliation as more trustworthy than other news sources. To test our hypothesis, 216 undergraduate students participated in a study that measured participants’ trustworthiness of a news article with randomized source attribution from a liberal, conservative, and neutral source. A 2X3 ANOVA tested the relationship between our participants’ political affiliation, measured by the 12-item Social …

Teaching With Passion And Compassion In Challenging Times: A Narrative Inquiry Into Elementary Teachers' Experiences In Georgia, Erin Scroggs

College of Graduate Studies: Theses & Dissertations

This study explores how teachers maintain their passion and compassion for teaching in spite of the impact of work-related challenges and subsequent obstacles upon their personal and professional lives. While much research has been conducted into teacher stress, very little has been done to connect the effects of stress on teachers’ health and passions for teaching. Abby, Nick, Passion, and Anna, four elementary school teachers from different areas, counties, schools, and school districts in the State of Georgia, participated in the study. Theoretically, I draw upon an array of works such as teaching towards freedom (Ayers, 2004, 2010, 2016), teachers …

Predicting College Enrollment During A Global Crisis, Jake Colin Hewins

Honors Theses and Capstones

This paper looks at how the COVID-19 pandemic has affected college enrollment at colleges and universities within New England, how this effect compares to the Great Recession of 2008-2009, and then predict future trends in total enrollment by first identifying the major factors of change in college enrollment during the Great Recession and COVID-19 pandemic. These factors include the perceived value of getting a degree by traditional and nontraditional students, where colleges and universities generate their revenue, and where and how students are enrolling in higher education, and the cost and value of online learning. Based on these factors, questions …

Teleneurology Based Management Of Infantile Spasms During Covid-19 Pandemic: A Consensus Report By The South Asia Allied West Syndrome Research Group, Priyanka Madaan, Jitendra Kumar Sahu, Jithangi Wanigasinghe, Kanij Fatema, Kyaw Linn, Mimi Lhamu Mynak, Nicolás Garófalo Gómez, Pauline Samia, Prakash Poudel, Prem Chand

Department of Paediatrics and Child Health

With telehealth services rescuing patients with chronic neurological disorders during the COVID-19 pandemic, there is a need for simplified teleneurology protocols for neurological disorders in children. Infantile spasms is an epileptic encephalopathy where treatment lag is a significant predictor of outcome. It is one such condition where telemedicine can make a remarkable difference when in-person consultations are delayed or are not possible. However, the adverse effect profile of the first-line therapeutic options, the need for frequent follow-up, underdeveloped telemedicine services, lack of a rational protocol, poor awareness about infantile spasms, a lesser level of parental understanding, and scarcity of pediatric …

Cardio-Pulmonary Sequelae In Recovered Covid-19 Patients: Considerations For Primary Care, Zouina Sarfraz, Azza Sarfraz, Alanna Barrios, Radhika Garimella, Asimina Dominari, Manish Kc, Krunal Pandav, Juan C. Pantoja, Varadha Retnakumar, Ivan Cherrez-Ojeda

Department of Paediatrics and Child Health

Background: Current literature lacks characterization of the post-recovery sequelae among COVID-19 patients. This review characterizes the course of clinical, laboratory, radiological findings during the primary infection period, and the complications post-recovery. Primary care findings are presented for long-COVID care.
Methods: Adhering to PRISMA guidelines, 4 databases were searched (PubMed, Embase, CINAHL Plus, Scopus) through December 5, 2020, using the keywords "COVID-19 and/or recovered and/or cardiovascular and/or long-term and/or sequelae and/or sub-acute and/or complication." We included published peer-reviewed case reports, case series, and cross-sectional studies providing the clinical course of COVID-19 infection, and cardiopulmonary complications of patients who recovered from COVID-19, …

Covid-19 Vaccine-Associated Thrombosis With Thrombocytopenia Syndrome (Tts): A Systematic Review And Post Hoc Analysis, Muhammad Usman Hafeez, Maha Ikram, Zunaira Shafiq, Azza Sarfraz, Zouina Sarfraz, Vikash Jaiswal, Muzna Sarfraz, Ivan Chérrez-Ojeda

Department of Paediatrics and Child Health

Background: A new clinical syndrome has been recognized following the COVID-19 vaccine, termed thrombosis with thrombocytopenia syndrome (TTS). The following systematic review focuses on extrapolating thrombotic risk factors, clinical manifestations, and outcomes of patients diagnosed with TTS following the COVID-19 vaccine.
Methods: We utilized the World Health Organization's criteria for a confirmed and probable case of TTS following COVID-19 vaccination and conducted a systematic review and posthoc analysis using the PRISMA 2020 statement. Data analysis was conducted using SPSS V25 for factors associated with mortality, including age, gender, anti-PF4/heparin antibodies, platelet nadir, D-dimer peak, time to event diagnosis, arterial or …

Videoconference Fatigue? Exploring Changes In Fatigue After Videoconference Meetings During Covid-19, Andrew A. Bennett, Emily D. Campion, Kathleen R. Keeler, Sheila K. Keener

Management Faculty Publications

In response to the COVID-19 global health pandemic, many employees transitioned to remote work, which included remote meetings. With this sudden shift, workers and the media began discussing videoconference fatigue, a potentially new phenomenon of feeling tired and exhausted attributed to a videoconference. In the present study, we examine the nature of videoconference fatigue, when this phenomenon occurs, and what videoconference characteristics are associated with fatigue using a mixed methods approach. Thematic analysis of qualitative responses indicates that videoconference fatigue exists, often in near temporal proximity to the videoconference, and is affected by various videoconference characteristics. Quantitative data was collected …

Assessing Transformation Of Optimizing Ambulatory Surgery Center Services With Telehealth, Kevin Vince Allison Jr.

MUSC Theses and Dissertations

Background: As technology advances and the ability to provide adequate and convenient surgical procedures improves; the usage of telehealth resources in an Ambulatory Surgery Center setting are evermore capable. The current environment of Ambulatory Surgery Center’s provides a baseline of support to alleviate main operating volume and to absorb more of the outpatient procedures with support from technology and telehealth. Objective: To understand how the telehealth abilities can enhance the efficiency and scope of service of Ambulatory Surgery Centers. To explore if telehealth resources can be utilized to strengthen, improve, and combine tasks that delay progress in the current model. …

Impact Of The Sars-Cov-2 Pandemic On Adolescents Living With Hiv In Lima, Peru, Renato A. Errea, Milagros Wong, Liz Senador, Alicia Ramos, Karen Ramos, Jerome T. Galea, Leonid Lecca, Hugo Sánchez, Carlos Benites, Molly F. Franke

Social Work Faculty Publications

Adolescents living with HIV (ALWH) have lower rates of virologic suppression and higher rates of immunologic decline compared to their older counterparts, potentially placing them at high-risk for developing severe SARS-CoV-2 disease. ALWH who are transitioning to adult care face additional challenges to remaining in care and adhering to treatment. In this special section we report the experiences of ALWH in the process of transitioning to adult HIV services during the COVID-19 pandemic. In first place, the government-mandated stay-at-home order has substantially limited access to full HIV care by restricting public transportation, HIV medication stock-outs, and the suspension of routine …

Protocol For Safe, Affordable, And Reproducible 1 Isolation And Quantitation 2 Of Sars-Cov-2 Rna From Wastewater, Monica Trujillo, Kristen Cheung, Anna Gao, Irene Hoxie, Sherin Kannoly, Nanami Kubota, Kaung Myat San, Davida S. Smyth, John J. Dennehy

Publications and Research

The following protocol describes our workflow for processing wastewater with the goal of detecting the genetic signal of SARS-CoV-2. The steps include pasteurization, virus concentration, RNA extraction, and quantification by RT-qPCR. We include auxiliary steps that provide new users with tools and strategies that will help troubleshoot key steps in the process. This protocol is one of the safest, cheapest, and most reproducible approaches for the detection of SARS-CoV-2 RNA in wastewater. Furthermore, the RNA obtained using this protocol, minus the pasteurization step, can be sequenced both using a targeted approach sequencing specific regions or the whole genome. The protocol …

Sentiment Analysis Of Long-Term Social Data During The Covid-19 Pandemic, Sophanna Ek, Marco Curci, Xiaokun Yang, Beiyu Lin, Pinchao Liu, Hailu Xu

Computer Science Faculty Publications

The COVID-19 pandemic has bringing the “infodemic” in the social media worlds. Various social platforms play a significant role in instantly acquiring the latest updates of the pandemic. Social media such as Twitter and Facebook produce vast amounts of posts related to the virus, vaccines, economics, and politics. In order to figure out how public opinion and sentiments are expressed during the pandemic, this work analyzes the long-term social posts from social media and conducts sentiment analysis on tweets within 12 months. Our findings show the trend topics of long-term social communities during the pandemic and express people’s attitudes towards …

The Decision To Play: College Football In The Era Of Covid-19, Jason Tabit

Undergraduate Honors Theses

COVID-19 upended life around the world, including on college campuses across the U.S. where institutions restructured their class modalities, campus life, extracurricular activities, and intercollegiate athletics - including college football. We examine the factors that led universities to make their decisions to play or not play college football during fall 2020, hypothesizing that the decision to play would be consistent with the decision about class modality for health and safety reasons, and that monetary and political motivations would also play a significant role. We collected data for 249 institutions and used logistic regression techniques to test our hypotheses. We ultimately …

The Hr Connection, Georgia Southern University

Human Resources (2010-2023)

• COVID-19 Manager's Guide
• Policy Updates
• Ahead Of Phase 1A+ of Vaccine Administration
• January Wellness Corner
• Introducing Percipio
• State Business Transactions Disclosure Reports

Nigeria’S Petroleum Industry Bill: A Missed Opportunity To Prepare For The Zero-Carbon Future, Solina Kennedy, Martin Dietrich Brauch, Perrine Toledano, Tehtena Mebratu-Tsegaye

Columbia Center on Sustainable Investment Staff Publications

With Nigeria’s National Assembly debating the proposed Petroleum Industry Bill (PIB) in the first quarter of 2021 – after nearly two decades of attempted reform of the country’s petroleum sector – Nigeria has a unique opportunity to rethink the role of the oil and gas industry in Nigeria’s economy and build out the country’s energy sector and economic capacity for the long term. CCSI’s report Equipping the Nigerian National Petroleum Corporation (NNPC) for the Low-Carbon Transition, released before the PIB was publicized, advances suggestions on how to do so. The PIB takes notable steps toward much-needed reform of NNPC’s …

Pandemics, Paid Sick Leaves, And Tax Institutions, Alex Zhang

Faculty Articles

The COVID-19 pandemic is currently ravaging the world, and the United States has been largely unsuccessful at containing the coronavirus. One long-standing policy failure stands out as having exacerbated the pandemic in our country: the lack of a national mandate of paid sick leaves, without which workers face financial and workplace-cultural pressures to attend work while sick, thus spreading the virus to their fellow employees and the public at large.

This Article provides the blueprint for a national, subsidized mandate of paid sick leaves and two additional insights about our tax institutions as mechanisms of effectuating broader societal goals. It …

(Un)Masking The Truth - The Cruel And Unusual Punishment Of Prisoners Amidst The Covid-19 Pandemic, Ariel Berkowitz

Touro Law Review

No abstract provided.

Getting Real: The Maryland Healthcare Ethics Committee Network’S Covid‑19 Working Group Debriefs Lessons Learned, Norton Elson, Howard Gwon, Diane Hoffmann, Adam M. Kelmenson, Ahmed Khan, Joanne F. Kraus, Casmir C. Onyegwara, Gail Povar, Fatima Sheikh, Anita J. Tarzian

Faculty Scholarship

No abstract provided.

Testing Privilege: Coaching Bar Takers Towards "Minimum Competency" During The 2020 Pandemic, Afton Cavanaugh

Faculty Articles

The year 2020 was challenging for the bar exam. The longstanding argument that the bar exam is not a fair measure of the minimum competence of someone to practice law was cast into harsh relief and the truth-that the bar exam tests the privilege of its examinees-became startlingly apparent. Not only did 2020 kick off with a devastating global pandemic, but we also saw the rage against systemic racial injustice reach a boiling point just as we were charged with staying in our homes to avoid contracting COVID-19. With a pandemic raging, overt White supremacy on the rise, and racial …

A Review On Covid-19 Related Research In Leading Information Systems Journals, Yuming He, Wenzhuo Li, Xin Tian, Yunfei Xing

Information Technology & Decision Sciences Faculty Publications

To identify the key challenges, issues and opportunities affecting individuals, organizations, and society on coping with COVID-19, we reviewed extant research related to the COVID-19 pandemic in the leading information systems journals. Six major research themes and representative literature for each theme are identified by content analysis. The six major research themes include digital transformation, data visualization and artificial intelligence, infodemic and cybersecurity, IT governance, digital divide, and IS research direction in the post-pandemic period. Moreover, we discussed the challenges, current research, and opportunities related to each of the themes. The review provides a snapshot of IS literature on the …

Belonging In College: Engagement And Retention At A Hispanic Serving Institution, Alana Joy Olschwang

CGU Theses & Dissertations

The goal of this study was to examine retention for first-year students who attended a large, public Hispanic Serving Institution (HSI). The study examined the extent that belonging influenced involvement and engagement, and the relationship to retention. This was in the context of COVID with the pandemic, social and political unrest, and an emergency remote format for teaching impacting student experiences. The conceptual framework was influenced by theories including validation, belonging, mattering, sociocultural engagement, natural growth, and community cultural wealth. The study included secondary data analysis from the Fall 2019 National Survey of Student Engagement and institutional data for grade …

Mortality Salience And Moral Dilemmas: The Impact Of Stress On Regret In Trolley Problem Decision-Making, Nicolas Perdomo

Master's Theses or Doctor of Nursing Practice

The present study experimentally investigated the effects of stress, in the form of mortality salience, on decision regret in participants presented with the trolley problem. Participants (N = 166) were recruited through Amazon Mechanical Turk and randomly assigned to a mortality salience or threatening control topic (dental pain) writing prompt and either the standard trolley problems (i.e., the "switch" and "footbridge" dilemmas) or an experimental reversal where the default was five people on the tracks instead of the usual one. The effects of mortality salience on affective regret, the trolley reversal on cognitive regret, and the relationship between mortality salience …

The Bake Sale: Fundraising And Social Justice In The 21st Century, Kelly E. Spivey

Electronic Theses and Dissertations

Bake sales have recently come to the forefront of our consciousness as a method of fundraising for social justice but the practice’s history reaches back to the 18th century. A readily available tool for women, baking was put to work to raise money for voting rights in the early 20th century. Less than fifty years later, bake sales appeared as a key fundraising tool for the civil rights movement. The reappearance of bake sales today stems from several factors, including the presidential election of Donald Trump in 2016, the appearance of COVID-19 in the United States in early 2020, and …

Impact Of Mental Health And Financial Status Of Essential And Non-Essential Workers That Continued Working Outside The Home During The Spring 2020 Covid-19 Shutdown, Adrianne Deveira

Theses and Dissertations--Public Health (M.P.H. & Dr.P.H.)

Objective: A global pandemic caused businesses in the United States to shutdown based on essential vs. non-essential criteria. There has been a lot of research discussing the impact of the shutdown on healthcare frontline workers. Little is known about other essential and non-essential workers, that continued working outside the home during the shutdown. The purpose of this paper is to examine the financial and mental health issues encountered by essential and non-essential workers that continued working outside the home during the Spring 2020 shutdown.

Methods: Snowball sampling of an online survey that was available from May 8 – June 6, …

Covid-19 Impact Research Brief: Virtual Exchanges At Community Colleges, Kimberley Cossey, Heidi Fischer

Educational Leadership & Workforce Development Faculty Publications

The COVID-19 pandemic has affected higher education worldwide. Two NAFSA member leaders, Kimberley Cossey, MA, (2021 registrar for Region VIII) and Heidi Fischer, PhD (2021 chair for Region VIII), have coauthored a research brief detailing how the COVID-19 pandemic impacted virtual exchange program development and delivery at community colleges in the United States. The research brief summarizes key takeaways from mixed-methods research (i.e., survey and interviews) with practitioners from U.S. community colleges, requesting information about:

The pandemic's impact on existing virtual exchange programs (VEPs), The impact on developing new VEPs, and New (virtual) models for international education. Key takeaways include …