Digital Commons Network^™

Histone Methyltransferase Ash1l Primes Metastases And Metabolic Reprogramming Of Macrophages In The Bone Niche, Chenling Meng, Kevin Lin, Wei Shi, Hongqi Teng, Xinhai Wan, Anna Debruine, Yin Wang, Xin Liang, Javier Leo, Feiyu Chen, Qianlin Gu, Jie Zhang, Vivien Van, Kiersten L Maldonado, Boyi Gan, Li Ma, Yue Lu, Di Zhao

Faculty, Staff and Student Publications

Bone metastasis is a major cause of cancer death; however, the epigenetic determinants driving this process remain elusive. Here, we report that histone methyltransferase ASH1L is genetically amplified and is required for bone metastasis in men with prostate cancer. ASH1L rewires histone methylations and cooperates with HIF-1α to induce pro-metastatic transcriptome in invading cancer cells, resulting in monocyte differentiation into lipid-associated macrophage (LA-TAM) and enhancing their pro-tumoral phenotype in the metastatic bone niche. We identified IGF-2 as a direct target of ASH1L/HIF-1α and mediates LA-TAMs' differentiation and phenotypic changes by reprogramming oxidative phosphorylation. Pharmacologic inhibition of the ASH1L-HIF-1α-macrophages axis elicits …

Leading Through Crisis: San Diego County Schools' Response To The Social Emotional Needs Of All Students, Johana Bielma

Dissertations

The COVID-19 pandemic led to unprecedented school closures, forcing administrators to take decisive action to radically change the educational system. The imperative to switch to remote learning transformed the dynamics of teaching and learning, leading to both immediate and long-term academic and social emotional consequences for all stakeholders. When schools reopened, administrators faced the challenge of reintegrating students into in-person learning while addressing the pandemic’s lasting effects on academics, mental health, and school safety. While academic regression was evident, the extent of students’ emotional struggles was less anticipated. Many students exhibited increased irritability and mental health issues such as depression …

Shifting To A Culture Of Inclusion By Design: Applying A Mixed-Methods Approach To Advance Accessibility Of Public Health Emergency Information & Communication Technology, Jessica L. Franks, Erin Vinoski Thomas

Developmental Disabilities Network Journal

Adults with intellectual and developmental disabilities (IDD) experience inequities in access to timely, accurate, and understandable information and communication technology (ICT), which increases risk for public health emergency (PHE)-related health disparities and impedes opportunities to achieve optimal health. This study assessed federal COVID-19 webpage accessibility levels and explored existing knowledge of and experience with filing accessibility complaints for federal ICT among adults with IDD. Through a mixed-methods approach, we evaluated compliance with accessibility standards for 18 federal agencies’ COVID-19 webpages (study 1) and interviewed 16 adults with IDD about experiences accessing federal webpages and filing accessibility complaints (study 2). We …

Voices Of Leadership: The Perceptions And Lived Experiences Of Principals Amid The Covid-19 Pandemic, Jeri Johnson

Graduate Theses & Dissertations

The COVID-19 pandemic created a crisis in schools. The purpose of this research is to explore the phenomenon and lived experiences of principals as they led their schools during COVID-19. This qualitative research will explore how principals navigated the complexity of leadership to sustain academic achievement. Principals will share how the three levels of crisis, danger and opportunity created a pathway for principal actions of effectiveness. Additionally, this research explored how principals made sense of the crisis to promote community, collaboration and compassion. Principals were asked to describe their perceptions of leadership and to share their lived experiences from March …

Exploring The Public Health Agency Of Canada’S And The Ontario Government’S Vaccine-Related Crisis Communication On X During The Covid-19 Pandemic, Sheraza Burney, Lori Donelle Phd, Rn, Fcan, Anita Kothari

Publications

Crisis communication strategies must be tailored to the unique nature of social media. In response to the COVID-19 pandemic, public health agencies have widely used social media to address vaccine hesitancy and misinformation. This research utilized the social media pandemic communication model to describe the key themes disseminated through the Ontario government and the Public Health Agency of Canada's vaccine-related crisis communication on X (formerly Twitter). Between 27 January 2020 and 6 April 2021, 1271 posts related to COVID-19 vaccination were collected from three official government X accounts—two from the province of Ontario and one from Canada. Posts were analyzed …

The Moderating Effect Of Political Ideology On The Relationship Between Locus Of Control And Covid-19-Related Anxiety And Stress, Sarah Boomhower

Walden Dissertations and Doctoral Studies

The COVID-19 pandemic created a mental health crisis within the United States. Previous research examining locus of control and mental health issues during the pandemic revealed that individuals with an external locus of control exhibited increased mental health symptoms. Research also found that political attitudes played a role regarding COVID-19 with liberal-leaning individuals and Democrats reporting higher levels of emotional distress during the pandemic. The purpose of this quantitative, nonexperimental, correlational study was to determine the extent to which political ideology moderates the relationship between locus of control and COVID-19-related anxiety and stress. Locus of control was the theoretical foundation …

Covid-19 And Related Adverse Neurological Complications, Hannah A. Wasson

Honors Thesis

Abstract

The COVID-19 pandemic changed the world drastically, and its impact was monumental. COVID-19 or SARS-CoV-2, or severe acute respiratory syndrome, was the virus responsible for causing such mayhem. This contagious virus can enter the body via different routes, live on surfaces for hours, and be transmitted through the air, increasing infection risk. Once it enters the body, it can trick the body into replicating the virus. From this reaction within the body, signs and symptoms follow. While the name indicates a respiratory illness, the virus can inflict injury on other parts of the body. Due to the organ systems …

A Virtual Wellness Program To Enhance Well-Being For Pediatric Oncology Staff During The Covid-19 Pandemic, Karen Moody, Maria Swartz, Zachary Gresham, Martha Askins, Laura Cahalan, Pavilia Francis, Christine Geistkemper, Amy Heaton, Ruitao Lin, Melissa Melo, Alakh Rajan, Madeline Smith, Priti Tewari, Keyana R. Williams, Cheng-Han Yang, Rhonda Robert

Advances in Cancer Education and Quality Improvement

In response to the COVID-19 global health crisis and mandated social isolation, Pediatric leadership at MD Anderson Children’s Cancer Hospital was concerned for the psychological impact on its workforce and encouraged wellness programming. A grassroots wellness taskforce was assembled for the Division of Pediatrics. The task force’s primary mission was to promote the well-being of clinicians and non-clinical staff members through a broadly accessible, sustainable, and effective virtual wellness program. Guided by the Stanford Model for Professional Fulfillment, a virtual program entitled, “Weekly Wellness Webex” for Pediatrics staff was launched. Weekly Wellness Webex is a 1-hour live-streamed program with varied …

Non-Ventilated Prone Positioning In The Covid-19 Population, Marie Delouche, Nishant Varghese, Christi Knapp, Jiangzhen Jenny Li, Michael Guffey, Danielle Guffey, Geraldine B. Jones

General Submissions: Clinical Settings Materials

In the population of confirmed COVID-19 positive patients on a telemetry unit, will proning every 2 hours result in a decreased length of stay for the intervention group (patients that prone) as opposed to the control group (patients that receive standard of care) over a period of 9 months (2021-2022)?

Lived Experiences Of Icu Nurses Caring For Critically Ill Patients Infected With Covid-19: A Phenomenological Study In Thailand, Charuedee Putruttanamaneekun, Yaowarat Matchim, Thitiporn Pathomjaruwat, Thanyarat Boontoi, Itsari Srisupha-Olarn, Sukanya Thongbupa, Borwarnluck Thongthawee, Parinya Raetong

Journal of Health Research

Background: COVID-19 is an emerging disease that caused infections and a pandemic worldwide. Intensive care unit (ICU) nurses played an important role in providing care for critically ill patients. Their experiences during the pandemic in Thailand were not well documented. This study explored the lived experiences of ICU nurses caring for critically ill patients infected with COVID-19 in Thailand.

Methods: We conducted a qualitative, phenomenological study guided by Gadamer’s philosophical hermeneutics. Data were collected between December 2021 and March 2023 among fifteen ICU nurses at a university hospital. The partcipants drew pictures reflecting their experiences; they participated in in-depth interviews …

How Did Women In India Fare During The Covid-19 Pandemic? A Study Of Work-Life Balance, Bigi Thomas

Journal of International Women's Studies

The COVID-19 pandemic has significantly impacted women globally, resulting in numerous work-life balance (WLB) challenges. The intersection of paid employment and familial obligations inside the household has compelled Indian women to assume many tasks. Married women encounter heightened stress due to the specific gender roles that society imposes upon them within a patriarchal sociocultural context; these gender roles were exacerbated by the COVID-19 pandemic, hindering Indian women in their management of domestic duties and reconciliation of personal and professional disputes. The pandemic’s fusion of professional and familial domains disrupted Indian women’s transition between home and work environments, leading to indistinct …

Elementary School Counselors Perceived Barriers To Service Delivery Throughout The Covid-19 Pandemic, Kimberly L. Johnson

Walden Dissertations and Doctoral Studies

Elementary school counselors are essential to shaping the foundation of academic, social, and emotional development of children which was negatively impacted by the COVID-19 pandemic. ESCs were required to maintain the same level of engagement despite the pressing circumstances. No one has explored the lived experiences of ESCs as they faced extreme barriers and without this study, stakeholders would be ill-equipped to address their needs. The purpose of this descriptive phenomenological study was to explore ESCs perceived barriers to comprehensive service delivery during the COVID-19 pandemic. Husserl’s descriptive phenomenological research approaches were used, including only ESCs who worked throughout the …

Time And Location: Physical Activity Trends In Parents And Children In A Rural Region During Covid-19, Brooke C. Towner, Robert Broce, Rebecca A. Battista

Journal of Appalachian Health

Introduction: COVID-19 restrictions altered the structure of the school and workday for families with children and led to changes in active transportation. Continued restrictions impacted access to many community locations and led to changes in physical activity (PA) behavior.

Purpose: The objectives of the study were to describe the changes in the 1) amount of PA time per day, 2) frequency of PA, and 3) sitting time. Information about how PA changed for parents and children during the COVID-19 pandemic will have potential implications for education, public health, and recreation management.

Methods: This cross-sectional study enlisted participants via an online …

Doctor Of Physical Therapy Student Performance On The National Physical Therapy Examination And Qualitative Feedback Of Dpt Program Administrators About The Covid-19 Pandemic In The Appalachian Region, Timothy Logan Yost

Ed.D. Dissertations

In this qualitative case study, I aimed to discern the presence of a downward trend in the National Physical Therapy Examination (NPTE) during the COVID-19 pandemic and receive valuable qualitative feedback from Doctor of Physical Therapy program administrators concerning the effects of COVID-19. I first reviewed the available literature, followed by an examination of first-time scores via publicly available data from the Federation of State Board of Physical Therapy (FSBPT). This was followed by the development of a qualitative research methodology, which included a targeted qualitative questionnaire with Doctor of Physical Therapy program administrators within the Appalachian region to gain …

Maternal Depression And Covid-19: A Secondary Analysis Comparing Postnatal Depression Rates During And Before The Covid-19 Pandemic, Amanda A. Berney

2025 Spring Honors Capstone Projects - Archive

The COVID-19 pandemic created increased psychological vulnerability across the globe through isolation, fear of infection, and misinformation from various sources, including social media. Women giving birth during the pandemic, therefore, may be extremely vulnerable psychologically. Per the World Health Organization, the years 2020 to mid 2021were designated as an intense time during the COVID-19 pandemic. Thus, the objective of this secondary analysis was to compare depression scores among women giving birth during these intense years and women giving birth before 2020. However, due to a small window of time and sample size, statistical analysis failed to find a correlation between …

The Value Of Home: The Covid-19 Pandemic’S Influence On Living Space, Mental Well-Being, And Design Adaptability, Grace E. Woodall

2025 Spring Honors Capstone Projects - Archive

Grace Woodall, Architecture

Title: The Value of Home: The COVID-19 Pandemic’s Influence on Living Spaces, Mental Well-Being, and Design Adaptability

Faculty Mentor: Marisa Gomez Nordyke

The COVID-19 pandemic redefined how people worked, learned, socialized, and lived. This study examines how American young adults’ perceptions of home evolved during and after the isolating lockdowns. This work addressed how the COVID-19 experience altered home’s value in young adults, the spatial, mental, and experiential challenges of confined spaces during the lockdowns, and the architectural elements that responded to these shifts. By analyzing post-pandemic housing trends, a literature review of architecture, psychology, home design, …

Examining The Lasting Impacts Of Covid-19 On College Students And Professors, Honor S. Luna, Alexia Angton

Sociology and Criminology Undergraduate Honors Theses

This study analyzes the impact of COVID-19 on the mental health, academic performance, and socialization of college students, as well as college professors’ perceptions of their own mental health, workload, and observed changes in students. University of Arkansas undergraduate students were surveyed online about their pandemic experiences, and faculty members were interviewed on similar topics. Students reported a noticeable decline in mental health, primarily due to isolation, being confined to their homes, and reduced contact with friends. Faculty faced stress from the rapid shift to virtual learning, decreased student engagement, and the challenge of balancing work and family while maintaining …

Student Perceptions Of School Climate And Safety After The Collective Trauma Of Covid-19 And Racial Injustice Syndemic., Amy Catherine Lyons

Electronic Theses and Dissertations

For people in marginalized communities, particularly the Black and African American community, the combined, disproportionate damage and loss from of the pandemic and a cacophony of racial injustices offer cause for labeling the phenomenon a syndemic. Syndemic is defined as “a conceptual framework for understanding diseases or health conditions that arise in populations and that are exacerbated by the social, economic, environmental, and political milieu in which a population is immersed” (Singer et al., 2017, p. 881). The purpose of this study is to explore, describe, and analyze Kentucky students’ perceptions of school climate and safety by demographic groups, racial …

Demographic Groups’ Use Of Agency Intimate Partner Violence (Ipv) Services: A Quality Improvement Project To Identify And Engage Local Underserved Populations, Mia Parker

Capstone Experience: Master of Public Health

This quality improvement project intended to identify populations of adult intimate partner violence (IPV) survivors in Spokane County, Washington, by race/ethnicity and sex who are underserved by a local victim service agency and provide action-oriented, evidence-informed recommendations that the agency may utilize to increase engagement with these local underserved populations. Methods used include secondary data analysis, timeline creation, literature review, and interpretation of quantitative and qualitative data analysis. This was a capstone project designed to demonstrate multiple public health competencies.

Administrative Law And The Pandemic, Gillian E. Metzger

Faculty Scholarship

American administrative law’s relationship to change is, as they say, compli­cated. On the one hand, continual evolution has been an endemic feature of American administrative law. Doctrines such as Chevron deference to agency statutory interpretations were born, grew, and declined in just the period from the 1980s to today. On the other, the United States (US) Supreme Court regularly rejects such common law development in administrative law as illegitimate and insists that federal judges must adhere to the original terms of the 1946 Administrative Procedure Act (APA) and other statutes, unless the Constitution requires otherwise. And to this day scholars …

The Kids Aren’T Alright: Changes In The Mental Health Of Adolescents Post-Covid-19, Tanya Belom

Education (PhD) Dissertations

Mental health is an increasing concern for today’s youth, with one in six U.S. children and adolescents aged 6-17 experiencing a mental health disorder each year, and 50% of all lifetime mental illnesses begin by age 14. The COVID-19 pandemic, which resulted in lockdowns, social isolation, school closures, and ultimately a disruption in everyday life, is believed to have adversely impacted the mental health of children and adolescents. There is limited research available on the impacts of the pandemic on adults, and even less research is available on the impact of the pandemic on youth, specifically as we navigate the …

Mental Health Crisis Of Medical Staffs During The Pandemic – How Has The Covid-19 Impacted Health Care Workers’ Mental Status, Yue Chen

Rowan-Virtua Research Day

The COVID-19 pandemic has waged a relentless battle against humanity, but amidst the physical toll lies a hidden front: the war on the mental health of our healthcare workers (HCWs).

Previous reviews have demonstrated a potential prevalence of mental health problems among HCWs, but these reviews necessitate updating and inclusion of more studies, along with a comparative analysis of pre- and post-pandemic backgrounds. Therefore, the aim of my study is to deliver updated prevalence estimates for mental health concerns among HCWs in the aftermath of the COVID-19 pandemic.

The results show not only a drastic increase in the percentage of …

Motivations And Goals For Combatting Covid-19 Misinformation In Clinical Setting: A Case Study Of Nursing Students., Amarachi H. Okoronkwo

All Theses

The misinformation surrounding COVID-19 disrupted public health efforts to mitigate the virus. This study examined the motivations and goals of nursing students to combat COVID-19 misinformation within clinical settings. Medical professionals are best suited to combat health misinformation due to their expertise and lived experience, but they are not mandated but encouraged to address COVID-19 misinformation. Grounded in qualitative research methods and grounded theory, semi-structured interviews were conducted with nursing students who have had clinical practice after the start of the COVID-19 pandemic. Findings reveal that the key motivations and goals for addressing misinformation include the need to educate patients, …

Risk Communication And Public Health Emergency Responses During Covid-19 Pandemic In Rural Communities In Kenya: A Cross-Sectional Study, Wilberforce Cholo, Fletcher J. Njororai, Walter Ogutu Amulla, Caleb Kogutu Nyaranga

Population Health Leadership and Analytics Faculty Publications and Presentations

Background: The COVID-19 pandemic highlighted the crucial role of community preventive behaviors in controlling the virus’ spread. Studies show that people’s risk perceptions and awareness significantly contribute to the containment and prevention of infections by motivating adoption of desired actions and behaviors. This study aimed at assessing the role of risk communication and factors that influenced responses during the COVID-19 pandemic in rural communities in Western Kenya. Methods: A descriptive cross-sectional study was conducted using a quantitative research approach, collecting data from 806 individuals across Kisumu, Vihiga, and Kakamega counties. Descriptive statistics were used to detail the demographic characteristics of …

An Exploration Of Substance Abuse By Healthcare Workers During The Covid-19 Pandemic: A Scoping Review, Andrew Hills

Capstone Experience: Master of Public Health

Objective

This scoping review aims to identify available literature and research on substance abuse by healthcare workers (HCWs) during the COVID-19 pandemic to examine whether the stress of their duties during the pandemic exacerbated existing issues of substance abuse.

Methods

A literature search using PubMed and Google Scholar using Harzing Publish or Perish identified 100 relevant professionally-authored, peer-reviewed, English-language academic articles published between 2015 and 2025 on substance abuse by HCWs. Exclusions were done via a review of the abstract and then from the full text, reducing the number of articles to three from those three articles which generated an …

Leadership Post Covid-19: Exploring The Lived Experiences Of Public-School Administrators And Support Through Professional Development, Teresa Marie Burr

Electronic Theses, Projects, and Dissertations

This qualitative study aimed to gather knowledge from the lived experiences of public school administrators before, during, and after the COVID-19 pandemic. Questions focused on the support and training received, experiences at school sites and online, and the lessons learned during this time. The literature review focused on issues that school administrators dealt with during this time. Challenges were varied, and solutions and information provided from the review indicated the need for communication, support, and planning. The theoretical framework was Activity Theory and Cultural Historical Activity Theory, which focused on the premise that an activity may be shared and taken …

The Effects Of A Two-Way Dual Language Program On The Educational Trajectory Of Hispanic Emergent Bilingual Students During The Impact Of The Covid-19 Pandemic: A Mixed-Methods Study, Jesus Jacob Villa

Open Access Theses & Dissertations

This explanatory mixed-methods study examines the impact of Dual Language Bilingual Education (DLBE) and Transitional Bilingual Education (TBE) programs on the academic achievement of Hispanic emergent bilingual students during and after the COVID-19 pandemic. With the U.S. Hispanic student population growing significantly, and emergent bilingual students historically underserved, this study addresses critical gaps in educational equity. Conducted in two school districts along the U.S. and Mexico border in Texas and New Mexico, the research explores how DLBE and TBE programs mitigated the pandemic's adverse effects on learning. This study analyzed quantitative data from standardized mathematics and language proficiency assessments for …

The Effects Of The Covid-19 Pandemic On Transit In The San Francisco Bay Area, Richard W. Lee, David B. Reinke, Christopher E. Ferrell, Charles Rivasplata, John M. Eells, Luana Chen

Mineta Transportation Institute

This report presents the findings from our study for the California State Assembly Transportation Committee on the effects of the COVID-19 pandemic on Bay Area Transit. The study consisted of a review of the literature on the effects of the pandemic on transit in the US, a detailed look at changes in ridership and economics for Bay Area transit agencies, comparisons of Bay Area transit ridership changes to those in similar US metropolitan areas, and analysis of possible remedies to restore the financial health of Bay Area transit agencies. Bay Area transit ridership has recovered somewhat from the depths of …

Maternal Drinking, Stress And Use Of Aggressive Parenting Over The Course Of The Covid-19 Pandemic, Jennifer Price Wolf, Bridget Freisthler

Faculty Research, Scholarly, and Creative Activity

Aims: The COVID-19 pandemic had a demonstrated impact on parenting but little is known about how parental drinking, stress, and use of aggressive discipline (a parenting behavior associated with abusive parenting and negative outcomes for children) have changed over time. We examine rates of alcohol use, stress, and aggressive discipline at three time points during the COVID-19 pandemic and investigate what maternal, child, and time-varying factors predict weekly use of aggressive parenting. Methods: We use longitudinal data from the Central Ohio Family Study (COFLS), including women (n = 234) with a child between the ages of 0–12 and recruited via …

School Counselors’ Lived Experiences During The Covid-19 Pandemic, Katie M. Guzman Dunn

Doctoral Dissertations and Projects

The purpose of this phenomenological study was to understand how school counselor perceptions of their roles may have been permanently impacted by the COVID-19 pandemic. Bronfenbrenner’s (1979) Ecological Systems Theory, which relates to the interactions of an individual and the environment around them, guided the study. The study’s central research was: What are public school counselors’ lived experiences regarding their role perception during the COVID-19 pandemic? Data was collected through virtual semi-structured interviews and photo elicitation with 10 school counselors who were members of the Kentucky School Counselor Association. The data collected from the interviews was analyzed using bracketing to …