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Articles 1051 - 1080 of 5698
Full-Text Articles in Entire DC Network
Exploring A Hispanic Community’S Well-Being During The Early Stage Of The Covid-19 Pandemic, Leyla Feize, Michael Machiorlatti, Enedina Enriquez
Exploring A Hispanic Community’S Well-Being During The Early Stage Of The Covid-19 Pandemic, Leyla Feize, Michael Machiorlatti, Enedina Enriquez
Research Symposium
Background: A crisis is a serious and stressful situation that brings instability and uncertainty. Although the COVID-19 crisis includes many characteristics of other crisis, it is unique in some respects. It is a worldwide life-threatening and long-term crisis with unknown consequences. The outcomes of the COVID-19 pandemic are mostly under exploration and investigation. The effects of the pandemic on mental health are incontrovertible. The impact of the COVID-19 pandemic on communities has not been uniform. In the early stage of the pandemic, when the country and the RGV were exhausted with the numbers of those infected with COVID and the …
Neutralizing Anti-Rbd Fraction For Sars-Cov-2 Is Associated With The Interaction Waist Circumference And Sex. An Esfuerso Preliminary Report On University Students, Juan C. Lopez-Alvarenga, Esperanza M. Garcia-Oropeza, Adriana L. Perales-Torres, Alvaro Diaz-Badillo, Lucia M. Perez-Navarro, Estrella Martinez-Lopez, Marisol Rosas-Diaz, Octelina Castillo-Ruiz, Laura Yanneth Ramirez-Quintanilla, Jacquelynne Cervantes, Edda Sciutto, Beatriz Tapia, Leonel Vela, Claudia Munguia-Cisneros, Carlos Ramirez-Pfeiffer
Neutralizing Anti-Rbd Fraction For Sars-Cov-2 Is Associated With The Interaction Waist Circumference And Sex. An Esfuerso Preliminary Report On University Students, Juan C. Lopez-Alvarenga, Esperanza M. Garcia-Oropeza, Adriana L. Perales-Torres, Alvaro Diaz-Badillo, Lucia M. Perez-Navarro, Estrella Martinez-Lopez, Marisol Rosas-Diaz, Octelina Castillo-Ruiz, Laura Yanneth Ramirez-Quintanilla, Jacquelynne Cervantes, Edda Sciutto, Beatriz Tapia, Leonel Vela, Claudia Munguia-Cisneros, Carlos Ramirez-Pfeiffer
Research Symposium
In a previous study we reported that 25% of college students had a family history of type 2 diabetes (T2D), and 39% of hypertension. Interestingly, between 17 to 47% reported not knowing about T2D or hypertension, neither the existing obesity-metabolic problems (ESFUERSO study). The COVID-19 pandemic forced confinement and modifications in food intake, physical activity, and psychological stress. This study aimed to analyze if the immune Ig-G anti-RBD (protective epitope in S protein) response associated with type of vaccination, metabolic risk, perceived stress, and history of COVID-19 contacts.
We included 116 students at the 3th year of follow up in …
Patient And Provider Perceptions Of Rapid Telehealth Implementation During The Covid-19 Pandemic, Ryan G. Seibert, Amanda K. Stephenson, Aubrey K. Podell, Yuxiu K. Lei, Sheri K. Keitz
Patient And Provider Perceptions Of Rapid Telehealth Implementation During The Covid-19 Pandemic, Ryan G. Seibert, Amanda K. Stephenson, Aubrey K. Podell, Yuxiu K. Lei, Sheri K. Keitz
The Lahey Journal
Introduction: Despite unprecedented telehealth adoption during the COVID-19 pandemic, its post-pandemic preservation remains uncertain. Understanding key stakeholders’ perspectives on telehealth during the pandemic can inform evidence-based policies and promote effective, sustainable virtual-based care.
Methods: Patients and providers who completed telehealth visits during the early pandemic in primary care, subspecialty, and surgical outpatient clinics at a large community-based academic medical center in New England were surveyed via telephone interviews or electronic surveys. Thematic analyses of qualitative comments further characterized experiences.
Results: Of 1,729 eligible patients called, 969 were contacted and 778 participated (response rate 80.3% among contacted patients). Among 753 eligible …
Mixed Method Approach Towards The Life Of University Students During The Covid-19 Pandemic, Raihan Khan, Andrew White, Tony Jehi
Mixed Method Approach Towards The Life Of University Students During The Covid-19 Pandemic, Raihan Khan, Andrew White, Tony Jehi
Department of Health Sciences - Faculty Scholarship
Background
The COVID-19 pandemic negatively impacted the higher education system. This mixed-methods study aimed to assess COVID-19 fear, anxiety, and stress among Shenandoah Valley college students.
Methods
An online survey was fielded and completed by n=680 students. Qualitative semi-structured interviews were conducted with 20 students.
Results
The mean participant age was 22.14±5.48 years, and primarily White (81.9%), women (80.4%), and undergraduate (78.0%) students. Approximately 41% were enrolled in health-related majors (41.4%). Women students had significantly higher anxiety, depression, and fear of contracting COVID-19 than men. Undergraduate students had significantly higher depression than graduate students. Qualitative analysis revealed several major themes: …
Examining Cancer Patients' Perceptions Of The Impact Of Covid-19 On Teleoncology: Findings From 15 Nigerian Outpatient Cancer Clinics, Adedayo Joseph, Abdul R. Shour, Nwamaka N. Lasebikan, Mutiu A. Jimoh, Bolanle C. Adegboyega, Emmanuella Nwachukwu, Opeyemi Awofeso, Azeezat Ajose, Abiola Ibraheem, Omolara Aminat Fatiregun, Musa Ali-Gombe, Usman M. Aliyu, Abdallah Elsaid Kotkat, Olusegun Abayomi Biyi-Olutunde, Evaristus Oseiwe Oboh, Ismail H. Zubairu, Mohammad Rifat Haider, Bankole Olatosi Ph.D., David Puthoff, Adedayo A. Onitilo
Examining Cancer Patients' Perceptions Of The Impact Of Covid-19 On Teleoncology: Findings From 15 Nigerian Outpatient Cancer Clinics, Adedayo Joseph, Abdul R. Shour, Nwamaka N. Lasebikan, Mutiu A. Jimoh, Bolanle C. Adegboyega, Emmanuella Nwachukwu, Opeyemi Awofeso, Azeezat Ajose, Abiola Ibraheem, Omolara Aminat Fatiregun, Musa Ali-Gombe, Usman M. Aliyu, Abdallah Elsaid Kotkat, Olusegun Abayomi Biyi-Olutunde, Evaristus Oseiwe Oboh, Ismail H. Zubairu, Mohammad Rifat Haider, Bankole Olatosi Ph.D., David Puthoff, Adedayo A. Onitilo
Faculty Publications
Purpose
To examine cancer patients' perspectives on the impact of COVID-19 on teleoncology in Nigeria.
Methods
Data from a multicenter survey conducted at 15 outpatient clinics to 1,097 patients with cancer from April and July 2020 were analyzed. The study outcome was telemedicine, defined as patients who reported their routine follow-up visits were converted to virtual visits because of COVID-19 (coded yes/no). Covariates included patient age, ethnicity, marital status, income, cancer treatment, service disruption, and cancer diagnosis/type. Stata/SE.v.17 (StataCorp, College Station, TX) was used to perform chi-square and logistic regression analyses. P values ≤ .05 were considered statistically significant.
Results …
Molecular Imaging Of Ace2 Expression In Infectious Disease And Cancer, Zhiyao Li, Abbie Hasson, Lasya Daggumati, Hanwen Zhang, Daniel L J Thorek
Molecular Imaging Of Ace2 Expression In Infectious Disease And Cancer, Zhiyao Li, Abbie Hasson, Lasya Daggumati, Hanwen Zhang, Daniel L J Thorek
2020-Current year OA Pubs
Angiotensin-converting enzyme 2 (ACE2) is a cell-surface receptor that plays a critical role in the pathogenesis of SARS-CoV-2 infection. Through the use of ligands engineered for the receptor, ACE2 imaging has emerged as a valuable tool for preclinical and clinical research. These can be used to visualize the expression and distribution of ACE2 in tissues and cells. A variety of techniques including optical, magnetic resonance, and nuclear medicine contrast agents have been developed and employed in the preclinical setting. Positron-emitting radiotracers for highly sensitive and quantitative tomography have also been translated in the context of SARS-CoV-2-infected and control patients. Together …
Comparative Analysis Of Covid-19 Non-Pharmaceutical Intervention Videos On Facebook: Insights From Nigeria And Benin Republic, Jimme Matyek, Sheba Umbule Tayo-Garbson, Philomena Effiong Umoren Phd, Benmun Paul, Emeka Williams Etumnu
Comparative Analysis Of Covid-19 Non-Pharmaceutical Intervention Videos On Facebook: Insights From Nigeria And Benin Republic, Jimme Matyek, Sheba Umbule Tayo-Garbson, Philomena Effiong Umoren Phd, Benmun Paul, Emeka Williams Etumnu
Library Philosophy and Practice (e-journal)
Facebook has been adopted by public health organisations for health promotion, psychoeducation and behaviour change campaigns. Studies have underscored the potential advantages of non-pharmaceutical interventions (NPIs) in decelerating the transmission of COVID-19 and mitigating its severe health consequences. However, these studies did not content analyse these NPI messages especially on Facebook. This study sought to investigate the phenomenon of NPI COVID-19 videos on Facebook that were viewed by Nigerians and Beninese. This study used quantitative content analysis as the research design and analysed 56 Nigerian videos and 36 Beninese videos totalling 92 on Facebook with an inter-rater reliability of 96%. …
Social Connectedness Between Family Caregivers And Older Adults Living In Long-Term Care Homes In The Context Of Covid-19, Anna Garnett, Hannah Pollock, Natalie Floriancic, Kristin Prentice, Lorie Donelle Phd, Rn, Fcan, Carri Hand, Abe Oudshoorn, Yolanda Babenko-Mould, Cheryl Forchuk
Social Connectedness Between Family Caregivers And Older Adults Living In Long-Term Care Homes In The Context Of Covid-19, Anna Garnett, Hannah Pollock, Natalie Floriancic, Kristin Prentice, Lorie Donelle Phd, Rn, Fcan, Carri Hand, Abe Oudshoorn, Yolanda Babenko-Mould, Cheryl Forchuk
Publications
The coronavirus disease (COVID-19) pandemic and resulting restrictions on physical access to long-term care homes culminated in health declines for older adults living there and their families. Knowledge gaps exist regarding maintaining social connectedness when physically separated. The study aimed to explore family members' perceptions of the impact that restrictions on physical access to long-term care homes had on the experience of social connectedness between family members and older adults living in long-term care. The method used was a qualitative description, using in-depth semi-structured interviews. Themes arising from inductive qualitative content analysis of 21 interviews with family members included: (a) …
The Effect Of Blended Learning And Virtual Learning On Student Performance In High School Physical Education, Frances E. Caulder
The Effect Of Blended Learning And Virtual Learning On Student Performance In High School Physical Education, Frances E. Caulder
Doctoral Dissertations and Projects
The relationship between blended, virtual, and traditional learning on student performance can significantly affect the future of physical education programs’ curriculum and instructional methods. This causal-comparative research design study examines the difference in student performance measured by FitnessGram® scores between ninth-grade female physical education students who participate in an all-online/virtual learning instructional model, a blended learning instructional model, and a traditional face-to-face learning instructional model. Using a random sample of 143 students from six physical education classes from two high schools in a rural South Carolina school district, a one-way ANOVA was conducted to examine the difference in student performance …
Progression Of Comorbidities In Youth With Overweight Or Obesity During The Covid-19 Pandemic., Erica Wee, Ashley K. Sherman, Safa Farrukh, Mark A. Clements, Kelsee Halpin, Yun Yan
Progression Of Comorbidities In Youth With Overweight Or Obesity During The Covid-19 Pandemic., Erica Wee, Ashley K. Sherman, Safa Farrukh, Mark A. Clements, Kelsee Halpin, Yun Yan
Manuscripts, Articles, Book Chapters and Other Papers
BACKGROUND: Childhood obesity rates have continued to increase with the COVID-19 pandemic. However, data are limited on the impact of increasing obesity on associated comorbidities.
METHODS: We evaluated the progression of overweight- or obesity-associated comorbidities by investigating change in laboratory results pre-COVID-19 pandemic and post-COVID-19 pandemic onset in youth with overweight or obesity. We defined progression of comorbidities based on increase in category rather than absolute change in value.
RESULTS: HbA1c progression was seen in 19%, and LDL cholesterol progression was seen in 26%, as defined by categories. HbA1c progression and LDL cholesterol progression were significantly correlated. HbA1c and LDL …
A New Dimension Of International Relations: The Role Of Science Diplomacy In Jordan’S Response To Covid-19, Emad A. Ayasreh
A New Dimension Of International Relations: The Role Of Science Diplomacy In Jordan’S Response To Covid-19, Emad A. Ayasreh
Association of Arab Universities Journal for Arts مجلة اتحاد الجامعات العربية للآداب
Science diplomacy is a rapidly growing field in foreign policy and international relations, gaining even greater importance since the onset of the Covid-19 pandemic. This study explores the substantial role of science diplomacy and international institutions in promoting coordinated efforts during Jordan’s response to the pandemic. It examines science diplomacy within the country and its increasing significance in addressing global challenges, with particular emphasis on its contributions to health diplomacy amid the pandemic. The researcher adopts a qualitative research methodology guided by a case study approach. Data were collected from various resources, including journal articles, official international and domestic reports, …
Machine Learning Techniques For The Identification Of Risk Factors Associated With Food Insecurity Among Adults In Arab Countries During The Covid-19 Pandemic, Radwan Qasrawi, Maha Hoteit, Reema Tayyem, Khlood Bookari, Haleama Al Sabbah, Iman Kamel, Somaia Dashti, Sabika Allehdan, Hiba Bawadi, Mostafa Waly, Mohammed O. Ibrahim, Stephanny Vicuna Polo, Diala Abu Al-Halawa
Machine Learning Techniques For The Identification Of Risk Factors Associated With Food Insecurity Among Adults In Arab Countries During The Covid-19 Pandemic, Radwan Qasrawi, Maha Hoteit, Reema Tayyem, Khlood Bookari, Haleama Al Sabbah, Iman Kamel, Somaia Dashti, Sabika Allehdan, Hiba Bawadi, Mostafa Waly, Mohammed O. Ibrahim, Stephanny Vicuna Polo, Diala Abu Al-Halawa
All Works
BACKGROUND: A direct consequence of global warming, and strongly correlated with poor physical and mental health, food insecurity is a rising global concern associated with low dietary intake. The Coronavirus pandemic has further aggravated food insecurity among vulnerable communities, and thus has sparked the global conversation of equal food access, food distribution, and improvement of food support programs. This research was designed to identify the key features associated with food insecurity during the COVID-19 pandemic using Machine learning techniques. Seven machine learning algorithms were used in the model, which used a dataset of 32 features. The model was designed to …
An Investigation Into The Effect Of Screen Time On Sleep Quality Amongst Third Level Students, Emma Kelly, Sarah Williams, Cliona Sutton
An Investigation Into The Effect Of Screen Time On Sleep Quality Amongst Third Level Students, Emma Kelly, Sarah Williams, Cliona Sutton
International Undergraduate Journal of Health Sciences
This paper aimed to research the effect of screen time on sleep quality based on the opinions of 356 third-level students from various Irish Universities. This study considers factors such as sleep duration, the effect of the COVID-19 pandemic concerning online college and its effect on sleep quality and screen time duration. This study was conducted using an anonymous Google Forms survey consisting of 10 questions and gained ethical approval before distribution.
Most participants (56.1%) slept between 7-9 hours, which is within the recommended guidelines of sleep duration by the Health Service Executive (HSE, 2022). When asked about the effect …
Full Issue: The International Undergraduate Journal Of Health Sciences, Volume 3, Issue 1, September 2023, Sword Mtu
International Undergraduate Journal of Health Sciences
Full Issue: The International Undergraduate Journal of Health Sciences, Volume 3, Issue 1, September 2023
The Covid Games: Resilience In The Shadow Of A Global Pandemic, Taylor D. Bunn
The Covid Games: Resilience In The Shadow Of A Global Pandemic, Taylor D. Bunn
Journal of Multicultural Affairs
This paper explores the student experience in North Texas through current research and interviews with students, parents, educators, and nonprofit leaders who leaned into the work of meeting basic needs in an extremely challenging time. The chapter begins with data on COVID-19 infection rates in the community and publicly available data from school districts and Texas Education Agency on academic achievement, grounding the chapter in quantitative facts. Next, findings from interviews provide context on the human impact of the pandemic. Parents and educators share their perspectives on the challenges students faced, unpacking what they wish they had known early in …
Nutrition-Related Experiences Of Women With Perinatal Depression During The Covid-19 Pandemic: A Qualitative Study, Dahlia Stott, Cynthia Klobodu, Lisa A. Chiarello, Bobbie Posmontier, Mona Egohail, Pamela A. Geller, June Andrews Horowitz, Brandy-Joe Milliron
Nutrition-Related Experiences Of Women With Perinatal Depression During The Covid-19 Pandemic: A Qualitative Study, Dahlia Stott, Cynthia Klobodu, Lisa A. Chiarello, Bobbie Posmontier, Mona Egohail, Pamela A. Geller, June Andrews Horowitz, Brandy-Joe Milliron
College of Nursing Faculty Papers & Presentations
Women with perinatal depression are at a high risk for unhealthy dietary behaviors but whether the coronavirus disease 2019 (COVID-19) pandemic has exacerbated this risk is unknown. Here we report the findings of a qualitative study exploring the impact of the COVID-19 pandemic on nutrition-related experiences of women with perinatal depression. Using a qualitative descriptive approach, in-depth interviews were conducted with 18 women with a history of perinatal depression and 10 healthcare providers. A semistructured format elicited how food and nutrition-related behaviors of women with perinatal depression were affected by the COVID-19 pandemic. Thematic analysis identified 4 themes related to …
The Public Health Impact Of Paxlovid Covid-19 Treatment In The United States, Yuan Bai, Zhanwei Du, Lin Wang, Eric H. Y. Lau, Isaac Fung, Petter Holme, Ben Cowling, Alison Galvani, Robert Krug, Lauren Ancel Meyers
The Public Health Impact Of Paxlovid Covid-19 Treatment In The United States, Yuan Bai, Zhanwei Du, Lin Wang, Eric H. Y. Lau, Isaac Fung, Petter Holme, Ben Cowling, Alison Galvani, Robert Krug, Lauren Ancel Meyers
Biostatistics, Epidemiology & Environmental Health Sciences: Faculty Publications
The antiviral drug Paxlovid has been shown to rapidly reduce viral load. Coupled with vaccination, timely administration of safe and effective antivirals could provide a path towards managing COVID-19 without restrictive non-pharmaceutical measures. Here, we estimate the population-level impacts of expanding treatment with Paxlovid in the US using a multi-scale mathematical model of SARS-CoV-2 transmission that incorporates the within-host viral load dynamics of the Omicron variant. We find that, under a low transmission scenario (Re∼1.2) treating 20% of symptomatic cases would be life and cost saving, leading to an estimated 0.26 (95% CrI: 0.03, 0.59) million hospitalizations averted, 30.61 (95% …
Rehabilitation Interventions For Physical Capacity And Quality Of Life In Adults With Post-Covid-19 Condition: A Systematic Review And Meta-Analysis., Dimitra V Pouliopoulou, Joy C Macdermid, Emily Saunders, Sue Peters, Laura Brunton, Erin Miller, Kieran L Quinn, Tiago V Pereira, Pavlos Bobos
Rehabilitation Interventions For Physical Capacity And Quality Of Life In Adults With Post-Covid-19 Condition: A Systematic Review And Meta-Analysis., Dimitra V Pouliopoulou, Joy C Macdermid, Emily Saunders, Sue Peters, Laura Brunton, Erin Miller, Kieran L Quinn, Tiago V Pereira, Pavlos Bobos
Physical Therapy Publications
IMPORTANCE: Current rehabilitation guidelines for patients with post-COVID-19 condition (PCC) are primarily based on expert opinions and observational data, and there is an urgent need for evidence-based rehabilitation interventions to support patients with PCC.
OBJECTIVE: To synthesize the findings of existing studies that report on physical capacity (including functional exercise capacity, muscle function, dyspnea, and respiratory function) and quality of life outcomes following rehabilitation interventions in patients with PCC.
DATA SOURCES: A systematic electronic search was performed from January 2020 until February 2023, in MEDLINE, Scopus, CINAHL, and the Clinical Trials Registry. Key terms that were used to identify potentially …
How Propaganda Affects Public Opinion In China: Evidence From The First Phase Of The Covid-19 Pandemic, Dan Chen
Political Science Faculty Publications
During a national crisis, can state propaganda shift public opinion, and if so, in what direction? Existing studies show that the effects of state propaganda on public opinion in China are mixed. Analysing data from an online survey experiment conducted during the initial phase of the COVID-19 pandemic in early 2020, this article finds that the Chinese public responded positively to propaganda that promoted Xi Jinping’s leadership, when these messages included text as well as images that showed Xi being compassionate during his visit to Wuhan. However, when textual propaganda focused on familiar narratives, such as Xi’s leadership, international praise …
The Impact Of Covid-19 On Carotid-Femoral Pulse Wave Velocity: A Systematic Review And Meta-Analysis, Iwona Jannasz, Michal Pruc, Mansur Rahnama-Hezavah, Tomasz Targowski, Robert Olszewski, Stepan Feduniw, Karolina Petryka, Lukasz Szarpak
The Impact Of Covid-19 On Carotid-Femoral Pulse Wave Velocity: A Systematic Review And Meta-Analysis, Iwona Jannasz, Michal Pruc, Mansur Rahnama-Hezavah, Tomasz Targowski, Robert Olszewski, Stepan Feduniw, Karolina Petryka, Lukasz Szarpak
Faculty, Staff and Students Publications
COVID-19 is a complex multisystemic disease that can result in long-term complications and, in severe cases, death. This study investigated the effect of COVID-19 on carotid–femoral pulse wave velocity (cfPWV) as a measurement to evaluate its impact on arterial stiffness and might help predict COVID-19-related cardiovascular (CV) complications. PubMed, Web of Science, Embase, and the Cochrane Library were searched for relevant studies, and meta-analysis was performed. The study protocol was registered in PROSPERO (nr. CRD42023434326). The Newcastle–Ottawa Quality Scale was used to evaluate the quality of the included studies. Nine studies reported cfPWV among COVID-19 patients and control groups. The …
Methemoglobinemia In The Setting Of G6pd Deficiency And Sars-Cov-2 Infection, Rinata Azizbayeva, Zachary Drennen, Risha Solanki, Vinay Edlukudige Keshava, Rama Bhagavatula, Meera Sareen, Rahim Ali Jiwani, Yazan Samhouri
Methemoglobinemia In The Setting Of G6pd Deficiency And Sars-Cov-2 Infection, Rinata Azizbayeva, Zachary Drennen, Risha Solanki, Vinay Edlukudige Keshava, Rama Bhagavatula, Meera Sareen, Rahim Ali Jiwani, Yazan Samhouri
Journal of Community Hospital Internal Medicine Perspectives
We report a case of a 58 year old African American male patient with Coronavirus Disease-2019 (COVID-19) in the setting of multiple concomitant hematologic disorders, including Glucose-6-phosphate dehydrogenase deficiency (G6PD deficiency) and sickle cell trait. Typically, G6PD deficiency remains clinically silent, and only a minority of patients will show signs of chronic hemolytic anemia. However, all G6PD deficient patients are at risk of non-immune hemolysis after exposure to a variety of infectious pathogens, including COVID-19. Our patient displayed evidence of methemoglobinemia and subsequent tissue anoxia. We review the theories and mechanisms behind the increased risk of complications and severity of …
Mental Health First Aid Training In Rural Maryland During The Covid-19 Pandemic: Program Implementation Through Virtual Delivery, Jee Hun Yoo, Alexander E. Chan, Stephanie Hutter-Thomas, Mariama Lukulay, Anna Kim, Alyssa K. Lucero, Ghaffar Hurtado Choque, Jinhee Kim
Mental Health First Aid Training In Rural Maryland During The Covid-19 Pandemic: Program Implementation Through Virtual Delivery, Jee Hun Yoo, Alexander E. Chan, Stephanie Hutter-Thomas, Mariama Lukulay, Anna Kim, Alyssa K. Lucero, Ghaffar Hurtado Choque, Jinhee Kim
Journal of Human Sciences and Extension
The growing mental health concerns during COVID-19, particularly among rural residents, is a public health emergency. Rural residents are at an elevated risk, as rurality has been associated with various disparities, including lower accessibility to mental health services. Maryland Rural Opioid Technical Assistance (ROTA; Maryland Extension) aimed to address this issue by delivering evidence-based programs on opioid misuse and mental health to rural community members and practitioners throughout Maryland when the COVID-19 pandemic hit the U.S. and all research activities had to transition to the virtual setting. The current study provides an overview of the implementation process of the Mental …
Safety And Efficacy Of Riluzole In Acute Spinal Cord Injury Study (Riscis): A Multi-Center, Randomized, Placebo-Controlled, Double-Blinded Trial, Michael G Fehlings, Wilson Z Ray, Et Al.
Safety And Efficacy Of Riluzole In Acute Spinal Cord Injury Study (Riscis): A Multi-Center, Randomized, Placebo-Controlled, Double-Blinded Trial, Michael G Fehlings, Wilson Z Ray, Et Al.
2020-Current year OA Pubs
Riluzole is a sodium-glutamate antagonist that attenuates neurodegeneration in amyotrophic lateral sclerosis (ALS). It has shown favorable results in promoting recovery in pre-clinical models of traumatic spinal cord injury (tSCI) and in early phase clinical trials. This study aimed to evaluate the efficacy and safety of riluzole in acute cervical tSCI. An international, multi-center, prospective, randomized, double-blinded, placebo-controlled, adaptive, Phase III trial (NCT01597518) was undertaken. Patients with American Spinal Injury Association Impairment Scale (AIS) A-C, cervical (C4-C8) tSCI, and <12 h from injury were randomized to receive either riluzole, at an oral dose of 100 mg twice per day (BID) for the first 24 h followed by 50 mg BID for the following 13 days, or placebo. The primary efficacy end-point was change in Upper Extremity Motor (UEM) scores at 180 days. The primary efficacy analyses were conducted on an intention to treat (ITT) and completed cases (CC) basis. The study was powered at a planned enrolment of 351 patients. The trial began in October 2013 and was halted by the sponsor on May 2020 (and terminated in April 2021) in the face of the global COVID-19 pandemic. One hundred ninety-three patients (54.9% of the pre-planned enrolment) were randomized with a follow-up rate of 82.7% at 180 days. At 180 days, in the CC population the riluzole-treated patients compared with placebo had a mean gain of 1.76 UEM scores (95% confidence interval: -2.54-6.06) and 2.86 total motor scores (CI: -6.79-12.52). No drug-related serious adverse events were associated with the use of riluzole. Additional pre-planned sensitivity analyses revealed that in the AIS C population, riluzole was associated with significant improvement in total motor scores (estimate: standard error [SE] 8.0; CI 1.5-14.4) and upper extremity motor scores (SE 13.8; CI 3.1-24.5) at 6 months. AIS B patients had higher reported independence, measured by the Spinal Cord Independence Measure score (45.3 vs. 27.3; d: 18.0 CI: -1.7-38.0) and change in mental health scores, measured by the Short Form 36 mental health domain (2.01 vs. -11.58; d: 13.2 CI: 1.2-24.8) at 180 days. AIS A patients who received riluzole had a higher average gain in neurological levels at 6 months compared with placebo (mean 0.50 levels gained vs. 0.12 in placebo; d: 0.38, CI: -0.2-0.9). The primary analysis did not achieve the predetermined end-point of efficacy for riluzole, likely related to insufficient power. However, on pre-planned secondary analyses, all subgroups of cervical SCI subjects (AIS grades A, B and C) treated with riluzole showed significant gains in functional recovery. The results of this trial may warrant further investigation to extend these findings. Moreover, guideline development groups may wish to assess the possible clinical relevance of the secondary outcome analyses, in light of the fact that SCI is an uncommon orphan disorder without an accepted neuroprotective treatment.
Two Stories To Tell: Different Student Outcome Measures Correlate With Different Instructor Adaptations To Covid-19, Quentin Charles Sedlacek, Lily Amador, Emily Beasley, Krysta Malech, Viviana Vigil, Heather Haeger, Corin V. Gray, Corin D. Slown
Two Stories To Tell: Different Student Outcome Measures Correlate With Different Instructor Adaptations To Covid-19, Quentin Charles Sedlacek, Lily Amador, Emily Beasley, Krysta Malech, Viviana Vigil, Heather Haeger, Corin V. Gray, Corin D. Slown
Biology, Agriculture and Chemistry Faculty Publications and Presentations
The coronavirus pandemic severely disrupted college students’ learning experiences. A growing body of research is attempting to examine the impact of faculty efforts to support students during this difficult time. However, different outcomes measures might lead to varying inferences about the impact of instructors’ adaptations to their pedagogy. We explore this potential for varying inferences through a mixed-methods study of 11 courses taught at a Hispanic-Serving Institution in the United States in Spring 2020. First, using qualitative analytical methods, we identify five types of instructional adaptations made by faculty. Second, we use quantitative methods to uncover associations between these instructional …
Recovery Of Lung Function After 149 Days On Extracorporeal Membrane Oxygenation For Covid-19, Orlando R Suero, Sri Kartik Valluri, Mario H Farias-Kovac, Leo Simpson, Gabriel Loor, Diana M Guerra, Jose L Diaz-Gomez, Subhasis Chatterjee
Recovery Of Lung Function After 149 Days On Extracorporeal Membrane Oxygenation For Covid-19, Orlando R Suero, Sri Kartik Valluri, Mario H Farias-Kovac, Leo Simpson, Gabriel Loor, Diana M Guerra, Jose L Diaz-Gomez, Subhasis Chatterjee
The Texas Heart Institute Journal
This report highlights survival and the patient’s perspective after prolonged venovenous extracorporeal membrane oxygenation (ECMO) for COVID-19–related respiratory failure.
A 36-year-old man with COVID-19 presented with fever, anosmia, and hypoxia. After respiratory deterioration necessitating intubation and lung-protective ventilation, he was referred for ECMO. After 3 days of conventional venovenous ECMO, he required multiple creative cannulation configurations. Adequate sedation and recurrent bradycardia were persistent challenges. After 149 consecutive days of ECMO, he recovered native lung function and was weaned from mechanical ventilation.
This represents the longest-duration ECMO support in a survivor of COVID-19 yet reported. Necessary strategies included unconventional cannulation and …
Making Waves: Integrating Wastewater Surveillance With Dynamic Modeling To Track And Predict Viral Outbreaks, Tin Phan, Samantha Brozak, Bruce Pell, Jeremiah Oghuan, Anna Gitter, Tao Hu, Ruy M Ribeiro, Ruian Ke, Kristina D Mena, Alan S Perelson, Yang Kuang, Fuqing Wu
Making Waves: Integrating Wastewater Surveillance With Dynamic Modeling To Track And Predict Viral Outbreaks, Tin Phan, Samantha Brozak, Bruce Pell, Jeremiah Oghuan, Anna Gitter, Tao Hu, Ruy M Ribeiro, Ruian Ke, Kristina D Mena, Alan S Perelson, Yang Kuang, Fuqing Wu
Faculty, Staff and Student Publications
Wastewater surveillance has proved to be a valuable tool to track the COVID-19 pandemic. However, most studies using wastewater surveillance data revolve around establishing correlations and lead time relative to reported case data. In this perspective, we advocate for the integration of wastewater surveillance data with dynamic within-host and between-host models to better understand, monitor, and predict viral disease outbreaks. Dynamic models overcome emblematic difficulties of using wastewater surveillance data such as establishing the temporal viral shedding profile. Complementarily, wastewater surveillance data bypasses the issues of time lag and underreporting in clinical case report data, thus enhancing the utility and …
Cancer Patients' Preferences And Perceptions Of Advantages And Disadvantages Of Telehealth Visits During The Covid-19 Pandemic, Deepika Kumar, Nancy Gordon, Constanza Zamani, Tammy Sheehan, Ernesto Martin, Olga Egorova, Jessica Payne, Tatjana Kolevska, Elad Neeman, Raymond Liu
Cancer Patients' Preferences And Perceptions Of Advantages And Disadvantages Of Telehealth Visits During The Covid-19 Pandemic, Deepika Kumar, Nancy Gordon, Constanza Zamani, Tammy Sheehan, Ernesto Martin, Olga Egorova, Jessica Payne, Tatjana Kolevska, Elad Neeman, Raymond Liu
Faculty, Staff and Student Publications
PURPOSE: We aimed to ascertain oncology patients' perceptions of telehealth versus in-person (IP) visits for different types of clinical encounters.
METHODS: We surveyed adults undergoing cancer treatment at Kaiser Permanente Northern California infusion centers between November 2021 and May 2022 using a self-administered questionnaire. Patients were asked about visit modality preferences (video, phone, and IP) for six types of clinical discussions, overall advantages and disadvantages of telehealth (video or phone) versus IP modalities, and barriers to video visit use.
RESULTS: The 839 patients who completed surveys in English were 63% female; median age 63 years; 64% White; and 73% college-educated …
Current Curricular Trends After The Covid-19 Pandemic: A National Survey Of Psychiatry Residency Programs, Jeff Wang Jin, Kacy Smith, Amanda Helminiak, Vineeth John, Hanjing Emily Wu
Current Curricular Trends After The Covid-19 Pandemic: A National Survey Of Psychiatry Residency Programs, Jeff Wang Jin, Kacy Smith, Amanda Helminiak, Vineeth John, Hanjing Emily Wu
Faculty, Staff and Student Publications
OBJECTIVES: During the COVID-19 pandemic, many psychiatry residencies (academic, community, and hybrid programs) have adopted different learning modalities to preserve a high quality of educational training. There is minimal data on specific program adaptations, related change perspectives, and program type stratification. This study sought to examine trends in curriculum changes in accredited psychiatry residency programs in the United States.
METHODS: Program directors of accredited general psychiatry programs in the United States were surveyed to assess both general program details and changes in educational content, delivery, and perspectives with regard to program curricula.
RESULTS: A total of 63 program directors out …
Pathobiology Of Myocardial Ischemia And Reperfusion Injury: Models, Modes, Molecular Mechanisms, Modulation, And Clinical Applications, L Maximilian Buja
Pathobiology Of Myocardial Ischemia And Reperfusion Injury: Models, Modes, Molecular Mechanisms, Modulation, And Clinical Applications, L Maximilian Buja
Faculty, Staff and Student Publications
This review presents an integrated approach to the analysis of myocardial ischemia and reperfusion injury and the modulating influence of myocardial conditioning during the evolution of acute myocardial infarction (AMI) and other clinical settings. Experimental studies have involved a spectrum of in vitro, ex vivo, and in vivo models, and guidelines have been developed for the conduct of rigorous preclinical studies and for the identification of various forms of cell injury and death in evolving AMI. AMI in vivo is dominated by oncosis (cell injury with swelling) leading to necroptosis and final necrosis of ischemic cardiomyocytes (CMCs), without or with …
Interstitial Lung Abnormalities After Hospitalization For Covid-19 In Patients With Cancer: A Prospective Cohort Study, Sungryong Noh, Christopher Bertini, Isabel Mira-Avendano, Maryam Kaous, Bela Patel, Saadia A Faiz, Vickie R Shannon, Diwakar D Balachandran, Lara Bashoura, Roberto Adachi, Scott E Evans, Burton Dickey, Carol Wu, Girish S Shroff, Joanna-Grace Manzano, Bruno Granwehr, Shannon Holloway, Kodwo Dickson, Alyssa Mohammed, Mayoora Muthu, Hui Song, Caroline Chung, Jia Wu, Lyndon Lee, Ying Jiang, Fareed Khawaja, Ajay Sheshadri
Interstitial Lung Abnormalities After Hospitalization For Covid-19 In Patients With Cancer: A Prospective Cohort Study, Sungryong Noh, Christopher Bertini, Isabel Mira-Avendano, Maryam Kaous, Bela Patel, Saadia A Faiz, Vickie R Shannon, Diwakar D Balachandran, Lara Bashoura, Roberto Adachi, Scott E Evans, Burton Dickey, Carol Wu, Girish S Shroff, Joanna-Grace Manzano, Bruno Granwehr, Shannon Holloway, Kodwo Dickson, Alyssa Mohammed, Mayoora Muthu, Hui Song, Caroline Chung, Jia Wu, Lyndon Lee, Ying Jiang, Fareed Khawaja, Ajay Sheshadri
Faculty, Staff and Student Publications
INTRODUCTION: Survivors of SARS-CoV-2 pneumonia often develop persistent respiratory symptom and interstitial lung abnormalities (ILAs) after infection. Risk factors for ILA development and duration of ILA persistence after SARS-CoV-2 infection are not well described in immunocompromised hosts, such as cancer patients.
METHODS: We conducted a prospective cohort study of 95 patients at a major cancer center and 45 patients at a tertiary referral center. We collected clinical and radiographic data during the index hospitalization for COVID-19 pneumonia and measured pneumonia severity using a semi-quantitative radiographic score, the Radiologic Severity Index (RSI). Patients were evaluated in post-COVID-19 clinics at 3 and …