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The Factors Predicting Pneumonia In Covid-19 Patients: Preliminary Results From Auniversity Hospital In Turkey, Hasan Selçuk Özger, Pinar Aysert Yildiz, Ümmügülsüm Gaygisiz, Asi̇ye Uğraş Di̇kmen, Zehra Demi̇rbaş Gülmez, Mehmet Yildiz, Esi̇n Şenol, Kenan Hizel, Özlem Güzel Tunçcan, Kayhan Çağlar, Gülendam Bozdayi, Nurdan Köktürk, Tansu Ulukavak Çi̇ftçi̇, Şahender Gülbi̇n Aygencel Bikmaz, Melda Türkoğlu

Turkish Journal of Medical Sciences

Background/aim: Pneumonia is the most serious clinical presentation of COVID-19. This study aimed to determine the demographic, clinical, and laboratory findings that can properly predict COVID-19 pneumonia. Materials and methods: This study was conducted in the Gazi University hospital. All hospitalized patients with confirmed and suspected SARS-CoV-2 infection between 16 March 2020 and 30 April 2020 were analyzed retrospectively. COVID-19 patients were separated into two groups, pneumonia and nonpneumonia, and then compared to determine predicting factors for COVID-19 pneumonia. Variables that had a P-value of less than 0.20 and were not correlated with each other were included in the logistic …

Covid-19 Experience Of The Major Pandemic Response Center In The Capital: Results Ofthe Pandemic's First Month In Turkey, Hati̇ce Rahmet Güner, İmran Hasanoğlu, Bi̇rcan Kayaaslan, Adalet Aypak, Ayşe Kaya Kalem, Fatma Eser, Burcu Özdemi̇r, Eli̇f Muki̇me Saricaoğlu, Müge Ayhan, Yeşi̇m Aybar Bi̇li̇r, Işil Özkoçak Turan, Deni̇z Erdem, Nevzat Mehmet Mutlu, Turan Buzğan, Bedi̇a Di̇nç

Turkish Journal of Medical Sciences

Background/aim: The aim of this study is to evaluate the epidemiological and clinical characteristics and parameters that determined the clinical course and prognosis of the COVID-19 patients admitted to Ankara City Hospital during the first month of the pandemic in Turkey. Materials and methods: SARS-CoV-2 PCR positive patients who were hospitalized between March 10 and April 10, 2020 were included. Results: Among 222 patients, mean age was higher in severe acute respiratory illness (SARI)/critical disease group (P < 0.001). Median time from illness onset to admission and presence of comorbidity, especially coronary artery disease and chronic obstructive pulmonary disease, were significantly higher in the SARI/critical disease group (P < 0.05). Cough and fever were the most common symptoms, while anosmia and loss of taste were observed in 8.6% and 7.7% patients, respectively. The mortality rate was 5.4%. A high neutrophil/lymphocyte ratio; low lymphocyte, monocyte, and platelet count; elevated liver enzymes; low GFR; and high levels of muscle enzymes, ferritin, and IL-6 on admission were found to be associated with SARI/critical disease (P < 0.05). Bilateral ground-glass opacity and patchy infiltration were more frequently seen in the SARI/critical disease group (P < 0.001). Patients older than 65 years had an 8-fold increased risk for development of SARI/critical disease. Conclusion: This cohort study regarding COVID-19 cases in Turkey reveals that older age, presence of comorbidity, bilateral infiltration on CT, high neutrophil/lymphocyte ratio, low monocyte and platelet count, elevated liver enzymes, low GFR, high levels of muscle enzymes, and high levels of ferritin and IL-6 on admission are predictors of SARI and severe disease.

Mobilizing The Research Ecosystem For Scientific Advances Towards Positive Impact In Thecontext Of The Covid-19 Pandemic, Hasan Mandal

Turkish Journal of Medical Sciences

This special issue of the Turkish Journal of Medical Sciences is dedicated to providing scientific advances in the process of better understanding the SARS-CoV-2 virus that causes the COVID-19 infection. The special issue is published in a special time in which science-based approaches, cocreation-based collaboration, and the effective utilization and integration of competences have a crucial role during the race against time while combating the COVID-19 pandemic. In this process, the Scientific and Technological Research Council of Turkey (TÜBİTAK), which publishes academic journals including the Turkish Journal of Medical Sciences, has taken rapid action to mobilize the research community. This …

Sars-Cov-2 Epidemiology And Control, Different Scenarios For Turkey, Eskild Petersen, Ayşe Deni̇z Gökengi̇n

Turkish Journal of Medical Sciences

Background/aim: Coronavirus Infectious Disease 2019 (COVID-19) is now a pandemic spreading in most countries including Turkey. Materials and methods: The current knowledge of COVID-19 and the virus causing it, SARS-CoV-2, was reviewed. The epidemiology and control in different countries was compared and the differences discussed. Results: The population attack rates and case fatality rates vary from country to country with Lombardy in northern Italy reporting an attack rate in the general population of 0.37% compared to 0.004% in Hong Kong. The differences are caused by different testing strategies and reporting systems. Conclusion: Turkey is early in the outbreak. Different control …

Understanding Dynamics Of Pandemics, Levent Akin, Mustafa Gökhan Gözel

Turkish Journal of Medical Sciences

Along the centuries, novel strain of virus such as influenza produces pandemics which increase illness, death and disruption in the countries. Spanish flu in 1918, Asian flu in 1957, Hong Kong flu in 1968 and swine flu in 2009 were known pandemic which had various characteristics in terms of morbidity and mortality. A current pandemic is caused by novel corona virus originated from China. COVID-19 pandemic is very similar to Spanish, Hong Kong, Asian and swine influenza pandemics in terms of spreading to world by the mobilized people. Burden of pandemic is considered in terms of disease transmissibility and the …

Coronaviruses And Sars-Cov-2, Mustafa Hasöksüz, Selçuk Kiliç, Fahri̇ye Saraç

Turkish Journal of Medical Sciences

Coronaviruses (CoVs) cause a broad spectrum of diseases in domestic and wild animals, poultry, and rodents, ranging from mild to severe enteric, respiratory, and systemic disease, and also cause the common cold or pneumonia in humans. Seven coronavirus species are known to cause human infection, 4 of which, HCoV 229E, HCoV NL63, HCoV HKU1 and HCoV OC43, typically cause cold symptoms in immunocompetent individuals. The others namely SARS-CoV (severe acute respiratory syndrome coronavirus), MERS-CoV (Middle East respiratory syndrome coronavirus) were zoonotic in origin and cause severe respiratory illness and fatalities. On 31 December 2019, the existence of patients with pneumonia …

Protective Measures For Covid-19 For Healthcare Providers And Laboratory Personnel, Canan Ağalar, Derya Öztürk Engi̇n

Turkish Journal of Medical Sciences

In the COVID-19 pandemic, which affects the whole world, healthcare professionals (HCP) are at high risk of transmission due to their direct contact with patients with COVID-19. Therefore, how to ensure the triage of the patient with acute respiratory symptoms should be determined in advance, the contact distance should be arranged to be at least 2 m, COVID-19 suspect or diagnosed patient should be instructed to wear a surgical mask. During the care of these patients, HCP should wear their personal protective equipment (PPE) in accordance with the procedure and should not neglect hand hygiene. The samples of the patient …

Radiological Approaches To Covid-19 Pneumonia, Müşerref Şule Akçay, Tevfi̇k Özlü, Aydin Yilmaz

Turkish Journal of Medical Sciences

COVID-19 pneumonia has high mortality rates. The symptoms are undiagnostic, the results of viral nucleic acid detection method (PCR) can delay, so that chest computerized tomography is often key diagnostic test in patients with possible COVID-19 pneumonia. In this review, we discussed the main radiological findings of this infection.

Covid-19: Pathogenesis, Genetic Polymorphism, Clinical Features And Laboratory Findings, Recep Öztürk

Turkish Journal of Medical Sciences

COVID-19 caused by a novel agent SARS-CoV-2 progressed to a pandemic condition and resulted in a major public health concern worldwide, leading to social and economic issues at the same time. The pathogenesis of COVID-19 starts with the bonding of the virus to ACE2 receptors expressed in many tissues, and the triggered excessive immune response plays a critical role in the course of the disease. The cytokine storm that occurs upon excessive production of pro-inflammatory cytokines is considered responsible for the severe progression of the disease and the organ damage. However, the accurate pathophysiological mechanism of the disease, which progresses …

Pennsylvania’S Covid-19 Response Vs. Homeland Security Frameworks And Research: Masking The Whole Community, Alexander Siedschlag

Publications

This essay offers an intermediate discussion of select policy, strategic, operational, and tactical issues that demonstrate where and how the Commonwealth of Pennsylvania’s novel coronavirus response on the one hand, and homeland security frameworks and research on the other, converge or—more often so—diverge, and how to narrow this gap. Although typically framed as a pandemic owned by the public health sector, the COVID-19 response falls directly within the homeland security mission space, whose core missions include “Ensuring Resilience to Disasters.” In some respects, Pennsylvania’s response exemplifies best practices suggested by research. In other dimensions, it is neither in line with …

Impact Of The Covid-19 Pandemic On Anaesthesia Trainees And Their Training, John R. Sneyd, Sophie E. Mathoulin, Ellen P. O'Sullivan, Vincent C. So, Fiona R. Roberts, Aaron A. Paul, Luis I. Cortinez, Russell S. Ampofo, Caitlynn J. Miller, Maxine A. Balkisson

More Faculty of Health Research

Coronavirus disease 2019 (COVID-19; severe acute respiratory syndrome coronavirus 2 [SARS-CoV-2] has dislocated clinical services and postgraduate training. To better understand and to document these impacts, we contacted anaesthesia trainees and trainers across six continents and collated their experiences during the pandemic. All aspects of training programmes have been affected. Trainees report that reduced caseload, sub-specialty experience, and supervised procedures are impairing learning. Cancelled educational activities, postponed examinations, and altered rotations threaten progression through training. Job prospects and international opportunities are downgraded. Work-related anxieties about provision of personal protective equipment, and risks to self and to colleagues are superimposed on …

The Value Of Anaesthesiologists In The Covid-19 Pandemic: A Model For Our Future Practice?, Wilton A. Van Klei, Markus W. Hollmann, J. Robert Sneyd

More Faculty of Health Research

No abstract provided.

An Insight Into The Epitope-Based Peptide Vaccine Design Strategy And Studies Against Covid-19, Murat Topuzoğullari, Tayfun Acar, Peli̇n Peli̇t Arayici, Burcu Uçar, Erennur Uğurel, Emrah Şefi̇k Abamor, Tüli̇n Arasoğlu, Di̇lek Balik, Serap Derman

Turkish Journal of Biology

SARS-CoV-2 is a new member of the coronavirus family and caused the pandemic of coronavirus disease 2019 (COVID-19) in 2020. It is crucial to design and produce an effective vaccine for the prevention of rapid transmission and possible deaths wcaused by the disease. Although intensive work and research are being carried out all over the world to develop a vaccine, an effective and approved formulation that can prevent the infection and limit the outbreak has not been announced yet. Among all types of vaccines, epitope-based peptide vaccines outshine with their low-cost production, easy modification in the structure, and safety. In …

Advanced Preparation Makes Research In Emergencies And Isolation Care Possible: The Case Of Novel Coronavirus Disease (Covid-19), David Brett-Major, Elizabeth R. Schnaubelt, Hannah M. Creager, Abigail Lowe, Theodore J. Cieslak, Jacob M. Dahlke, Daniel W. Johnson, Paul D. Fey, Keith F. Hansen, Angela L. Hewlett, Bruce G. Gordon, Andre C. Kalil, Ali S. Khan, Mark G. Kortepeter, Christopher J. Kratochvil, Luann Larson, Deborah A. Levy, James Linder, Sharon J. Medcalf, Mark E. Rupp, Michelle M. Schwedhelm, James N. Sullivan Md, Angela M. Vasa, Michael C. Wadman, Rachel E. Lookadoo, John-Martin J. Lowe, James V. Lawler, M. Jana Broadhurst

Journal Articles: Epidemiology

The optimal time to initiate research on emergencies is before they occur. However, timely initiation of high-quality research may launch during an emergency under the right conditions. These include an appropriate context, clarity in scientific aims, preexisting resources, strong operational and research structures that are facile, and good governance. Here, Nebraskan rapid research efforts early during the 2020 coronavirus disease pandemic, while participating in the first use of U.S. federal quarantine in 50 years, are described from these aspects, as the global experience with this severe emerging infection grew apace. The experience has lessons in purpose, structure, function, and performance …

Criminal Law In Crisis, Benjamin Levin

Scholarship@WashULaw

In this Essay, I offer a brief account of how the COVID-19 pandemic lays bare the realities and structural flaws of the carceral state. I provide two primary examples or illustrations, but they are not meant to serve as an exhaustive list. Rather, by highlighting these issues, problems, or (perhaps) features, I mean to suggest that this moment of crisis should serve not just as an opportunity to marshal resources to address the pandemic, but also as a chance to address the harsh realities of the U.S. criminal system. Further, my claim isn’t that criminal law is in some way …

Responding To The "Unknown Assailant": A Qualitative Exploration With Australian Health And Aged Care Chaplains On The Impact Of Covid-19, Kate Fiona Jones, Jennifer Washington, Matthew Kearney, Megan C. Best

IES Papers and Journal Articles

The global coronavirus pandemic (COVID-19) has brought about physical, psychological and spiritual challenges within health and aged care services across Australia. The aim of this study was to consider the impact of COVID-19 from the perspective of Australian chaplains. Semi-structured interviews were conducted with 17 chaplains. A grounded theory analysis identified three overarching themes: (1) a changing healthcare environment; (2) the impact of the virus; and (3) chaplains responding to the crisis. Increased healthcare restrictions in response to COVID-19 raised levels of fear and anxiety among patients, residents, family members and staff, and generated feelings of isolation and disconnection. Chaplains …

Assessing The Elevation Of Cardiac Biomarkers And The Severity Of Covid-19 Infection: A Meta-Analysis, Cucnhat Walker, Subrata Deb, Hua Ling, Zhe Wang

PCOM Scholarly Works

- Purpose: Since December 2019, coronavirus disease 2019 infection has become a global pandemic. The cases of Coronavirus Disease 2019 (COVID-19)-related acute cardiac injury with unknown pathophysiologic mechanism has become increasingly prevalent. However, it is not yet understood how the extent of cardiac injury differs with the intensity of viral infection. In the current study, we aimed to assess the association between elevated cardiac biomarkers and the severity of COVID-19 infection.

METHODS: A systematic literature search was performed across PubMed and Embase databases from December 1, 2019 to July 10, 2020, to identify studies that reported cardiac biomarkers of troponin …

Law, Structural Racism, And The Covid-19 Pandemic, Ruqaiijah Yearby, Seema Mohapatra

All Faculty Scholarship

Racial and ethnic minorities have always been the most impacted by pandemics because of: disparities in exposure to the virus; disparities in susceptibility to contracting the virus; and disparities in treatment. This article explains how structural racism, the ways in which laws are used to advantage the majority and disadvantage racial and ethnic minorities, has caused these disparities. Specifically, this article focuses on how employment, housing, health care, and COVID-19 relief laws have been manipulated to disadvantage racial and ethnic minorities, making minorities more susceptible to COVID-19 infection and death. This article uses Blumenshine’s 2008 framework to outline how structural …

Covid-19 Risk Among Temporary Protected Status Beneficiaries, Diana Estefania Estrada Alamo

Public Health Theses

The current federal response of the United States to the COVID-19 pandemic has created conditions and resulted in unintended consequences that may be disproportionately increasing the risk of COVID-19 infection and sequelae for immigrant populations. This investigative thesis explores whether states with a greater percentage of Temporary Protected Status beneficiaries experience more COVID-19 related deaths as compared to the rest of the United States. Using a multiple linear regression model for statistical analysis, covariates under consideration include the number of COVID-19 confirmed cases, tests performed, hospitalizations reported, as well as the population density of each state and the proportion of …

Dispute Resolution In Pandemic Circumstances, George A. Bermann

Faculty Scholarship

The peaceful resolution of disputes is among the most important earmarks of a regime attached to the rule of law. Even in countries in which, for one reason or another, courts do not work especially well, civil peace is of paramount importance. The absence of effective institutions for the administration of justice between and among private parties would spell a high degree of social disorder.

Even in the absence of a crisis such as we are experiencing, justice systems face a number of challenges in this day and age. Does a jurisdiction have a sufficient number of persons qualified to …

Unsafe At Any Campus: Don't Let Colleges Become The Next Cruise Ships, Nursing Homes, And Food Processing Plants, Peter H. Huang, Debra S. Austin

Publications

The decision to educate our students via in-person or online learning environments while COVID-19 is unrestrained is a false choice, when the clear path to achieve our chief objective safely, the education of our students, can be done online. Our decision-making should be guided by the overriding principle that people matter more than money. We recognize that lost tuition revenue if students delay or defer education is an institutional concern, but we posit that many students and parents would prefer a safer online alternative to riskier in-person options, especially as we get closer to fall, and American death tolls rise. …

Digital Equity In The Time Of Covid-19: The Access Issue, Jonathan D. Becker, Joy Washington, David Naff, Andrea Woodard, Joan A. Rhodes

MERC Publications

This report is a part of a series of reports on digital equity in the time of COVID-19 written by members of the MERC SY20 study team. MERC launched the SY20 project to provide rapid response, iterative research to help address immediate and enduring needs by school divisions in metropolitan Richmond. The project has the following goals: (1) To convene conversations between scholars and practitioners on critical topics in public education relevant to the moment, (2) To share examples of local efforts that illustrate innovation and best practice, (3) To encourage community engagement and dialogue on our work through broad …

Sars-Cov-2 Updates In A West African Population And Precautionary Measures For Sustaining Quality Antenatal Care Delivery, Emmanuel Komla Senanu Morhe, Enoch Odame Anto, David Anthony Coall, Eric Adua, Alexander Yaw Debrah, Otchere Addai-Mensah, Michael Owusu, William K.B.A. Owiredu, Christian Obirikorang, Emmanuel Akomanin Asiamah, Emmanuel Acheampong, Evan Adu Asamoah, Lydia Abradu, Agartha Odame Anto, Youxin Wang, Haifeng Hou, Wei Wang

Research outputs 2014 to 2021

No abstract provided.

Unintended Impacts On Entrepreneurs During Covid-19 – Pandemic Creates Unforeseeable Opportunities Of A Lifetime, Ryan Matthews

Atlantic Marketing Journal

Select entrepreneurs are successful for a reason. One reason being, they have been able to use their skills to execute during times of chaos and panic, sometimes using these times as an opportunity to identify and exploit new or existing opportunities. Now and then, the external business environment changes in a manner that was never imagined or planned, therefore creating unintended impacts or new opportunities. During times of chaos, will these entrepreneurs pursue newly present opportunities that were not planned, or will they stick to their comfort zone? While several studies have been conducted looking at the characteristics of the …

Misinformation Mayhem: Social Media Platforms’ Efforts To Combat Medical And Political Misinformation, Dawn C. Nunziato

GW Law Faculty Publications & Other Works

Social media platforms today are playing an ever-expanding role in shaping the contours of today’s information ecosystem. The events of recent months have driven home this development, as the platforms have shouldered the burden and attempted to rise to the challenge of ensuring that the public is informed – and not misinformed – about matters affecting our democratic institutions in the context of our elections, as well as about matters affecting our very health and lives in the context of the pandemic. This Article examines the extensive role recently assumed by social media platforms in the marketplace of ideas in …

Turnaround Management Of Airport Service Providers Operating During Covid-19 Restrictions, Bassam Buhusayen, Pi-Shen Seet, Alan Coetzer

Research outputs 2014 to 2021

© 2020 by the authors. Licensee MDPI, Basel, Switzerland. Many sectors worldwide have been impacted by government restrictions resulting from the COVID-19 pandemic. For example, restrictions on travel have resulted in major losses for organizations operating within the aviation sector. This study aims to emphasize the challenges faced by these organizations while they implement turnaround management strategies. The study is based on 30 semi-structured interviews with frontline managers working for airline service providers in three different departments of an airport in Australia. The organization has implemented several turnaround management strategies to survive the crisis caused by COVID-19 restrictions, creating new …

The Assessment Of The Serum Levels Of Tweak And Prostaglandin F2∝ In Covid - 19, Demet Yalçin Kehri̇bar, Mustafa Ci̇hangi̇roğlu, Emi̇ne Sehmen, Bahatti̇n Avci, Mustafa Çapraz, Maruf Boran, Caner Günaydin, Meti̇n Özgen

Turkish Journal of Medical Sciences

Background/aim: It is claimed that aberrant immune response has a more important role than the cytopathic effect of the virus in the morbidity and mortality of the coronavirus disease 2019 (COVID-19). We aimed to investigate the possible roles of tumor necrosis factor-like weak inducer of apoptosis (TWEAK)/Fn14 pathway and leukotrienes (LT) in uncontrolled immune response that occurs in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Materials and methods: This study included 25 asymptomatic patients and 35 patients with lung involvement who were diagnosed with COVID-19 as well as 22 healthy volunteers. Lung involvement was determined using computed-tomography. Serum TWEAK, LTE4, …

Ensuring Access To Emerging Covid-19 Treatments Through Medicare Reimbursement Policy, Rachel Sachs, Adam Sacarny

Scholarship@WashULaw

Effective pharmaceutical treatments for coronavirus disease 2019 (COVID-19) are urgently needed, and there has been an explosion of research into compounds with potential efficacy against the disease. The highest-profile success to date is Gilead Sciences’ antiviral remdesivir, which received an Emergency Use Authorization (EUA) from the US Food and Drug Administration (FDA) after preliminary data showed that it may speed patients’ time to recovery.¹ Gilead is just beginning to sell remdesivir commercially. However, Medicare reimbursement policy is likely to pose challenges for hospitals seeking to administer remdesivir and other COVID-19 drugs to patients. Policy makers ought to think critically …

Covid-19 Sampling From The Middle Ear And Mastoid: A Case Report, George B Wanna, Zachary G Schwam, Vivian F Kaul, Maura K Cosetti, Enrique Perez, Peter Filip, Waleed Javaid, Avi Kandel, Alberto Paniz-Mondolfi, Satish Govindaraj, Eric M Genden

Faculty, Staff and Student Publications

No abstract provided.

States Of Emergency And Human Rights During A Pandemic: A Hungarian Case Study, Megan Cox

Human Rights Brief

No abstract provided.