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Articles 541 - 570 of 6918
Full-Text Articles in Entire DC Network
Long-Term Symptom Burden In A Young, Ambulatory Cohort After The Omicron Outbreak In China, Simeng Ren, Yumeng Tan, Hongkun Xu, Mian Wang, Rumei Xiang, Jiayue Jin, Baojin Han, Jiaheng Shi, Jingyu Zhang, Jinliang Yang, Xin Tian, Ying Li, Jiaojiao Chen, Wenzheng Zhang, Jingqi Yang, Xin Shelley Wang, Qiuling Shi, Jie Liu
Long-Term Symptom Burden In A Young, Ambulatory Cohort After The Omicron Outbreak In China, Simeng Ren, Yumeng Tan, Hongkun Xu, Mian Wang, Rumei Xiang, Jiayue Jin, Baojin Han, Jiaheng Shi, Jingyu Zhang, Jinliang Yang, Xin Tian, Ying Li, Jiaojiao Chen, Wenzheng Zhang, Jingqi Yang, Xin Shelley Wang, Qiuling Shi, Jie Liu
Faculty, Staff and Student Publications
Introduction: At the end of 2022, an outbreak of the Omicron BF.7 and BA.5.2 subvariants of SARS-CoV-2 occurred in China. In this prospective cohort study, we investigated the pattern of development of major symptom burden and influencing factors in infected Chinese patients.
Methods: First-time infected outpatients were enrolled from December 7, 2022, to January 11, 2023 (N = 355). The prevalence of symptoms was monitored by a repeated patient-reported quantitative symptom survey over nine months.
Results: At the onset of the infection, the most prevalent symptoms (score ≥1 on a 0-10 numeric rating scale) were fatigue (91.8%), cough (91.8%), …
Trends In Science Outreach Research Through Social Media (2000-2023): A Comprehensive Bibliometric Analysis, María Del Pilar Quezada Castro, Marco Antonio Rodríguez Vega, María Del Pilar Castro Arellano, Guillermo Alexander Quezada Castro
Trends In Science Outreach Research Through Social Media (2000-2023): A Comprehensive Bibliometric Analysis, María Del Pilar Quezada Castro, Marco Antonio Rodríguez Vega, María Del Pilar Castro Arellano, Guillermo Alexander Quezada Castro
Health Professions Education
Purpose: Scientific dissemination is key to transmitting specialized knowledge to society, using social networks and digital platforms as essential tools. This study aims to conduct a comprehensive bibliometric analysis to identify trends, key themes, and collaboration networks in scientific outreach research.
Methods: A bibliometric analysis of 1577 papers indexed in the Scopus database between 2000 and 2023 was conducted using advanced tools such as Biblioshiny and VOSviewer. The analysis focused on co-authorship patterns, citation networks, and emerging thematic trends.
Results: The findings showed exponential growth in scientific output over the last four years, shaped by the impact of the COVID-19 …
Quantitatively Assessing The Impact Of The Quality Of Snomed Ct Subtype Hierarchy On Cohort Queries, Xubing Hao, Xiaojin Li, Yan Huang, Jay Shi, Rashmie Abeysinghe, Cui Tao, Kirk Roberts, Guo-Qiang Zhang, Licong Cui
Quantitatively Assessing The Impact Of The Quality Of Snomed Ct Subtype Hierarchy On Cohort Queries, Xubing Hao, Xiaojin Li, Yan Huang, Jay Shi, Rashmie Abeysinghe, Cui Tao, Kirk Roberts, Guo-Qiang Zhang, Licong Cui
Faculty, Staff and Student Publications
Objective: SNOMED CT provides a standardized terminology for clinical concepts, allowing cohort queries over heterogeneous clinical data including Electronic Health Records (EHRs). While it is intuitive that missing and inaccurate subtype (or is-a) relations in SNOMED CT reduce the recall and precision of cohort queries, the extent of these impacts has not been formally assessed. This study fills this gap by developing quantitative metrics to measure these impacts and performing statistical analysis on their significance.
Material and methods: We used the Optum de-identified COVID-19 Electronic Health Record dataset. We defined micro-averaged and macro-averaged recall and precision metrics to assess the …
Trends In Contacts Made By Immigrants To The National Domestic Violence Hotline, Before And During The Covid-19 Pandemic, Sarah Treves-Kagan, Vi D Le, Liris S Berra, Colleen M Ray, Yanet Ruvalcaba, Leila Wood, Denise V D'Angelo, Tatiana M Vera, Lianne Fuino Estefan
Trends In Contacts Made By Immigrants To The National Domestic Violence Hotline, Before And During The Covid-19 Pandemic, Sarah Treves-Kagan, Vi D Le, Liris S Berra, Colleen M Ray, Yanet Ruvalcaba, Leila Wood, Denise V D'Angelo, Tatiana M Vera, Lianne Fuino Estefan
Faculty, Staff and Student Publications
Objectives: Immigrants in the United States are more likely than nonimmigrants to experience risk factors for intimate partner violence (IPV) and problems in getting support. The COVID-19 pandemic and recent incidents of xenophobia and anti-immigrant sentiment may have exacerbated exposure to IPV risk factors. We examined immigrant experiences of IPV before and during the COVID-19 pandemic.
Methods: This study identified changes in characteristics of abuse, services used, referrals, and barriers to services among those who contacted the National Domestic Violence Hotline (NDVH) and identified as immigrants, reported immigration status as a concern, needed immigration support, and/or identified immigration status as …
Changes In The Spatiotemporal Patterns Of Covid-19 In Japan From 2020 Through 2023, Atsuna Tokumoto, Kazuaki Jindai, Tomoki Nakaya, Mayuko Saito, Clive E Sabel, Hitoshi Oshitani
Changes In The Spatiotemporal Patterns Of Covid-19 In Japan From 2020 Through 2023, Atsuna Tokumoto, Kazuaki Jindai, Tomoki Nakaya, Mayuko Saito, Clive E Sabel, Hitoshi Oshitani
School of Geography, Earth and Environmental Sciences
BACKGROUND: The spread of coronavirus disease 2019 (COVID-19) varied among countries. The spatiotemporal trends of COVID-19 in Japan remain understudied. Therefore, this study aimed to conduct a detailed investigation of the spatiotemporal evolution of infections/deaths across prefectures in Japan, to analyze the changing patterns of COVID-19 circulation in metropolitan and nonmetropolitan areas.
METHODS: We extracted data from nationally represented open-source data from January 15, 2020, to May 9, 2023, and we calculated the incidence rate of infection and the mortality. Further the ratios were obtained by dividing those rates in prefectural level by those in national level to make them …
Representative National Survey On Drug Use During The Covid-19 Stay-At-Home Order In The Usa, Soo-Hoon Lee, Bernadette Cullen, Alidon Athey, Calliope Holingue, Michelle R. Kaufman, Paul Nestadt, Jack Samuels, Tracy Vannorsdall, Phillip Phan
Representative National Survey On Drug Use During The Covid-19 Stay-At-Home Order In The Usa, Soo-Hoon Lee, Bernadette Cullen, Alidon Athey, Calliope Holingue, Michelle R. Kaufman, Paul Nestadt, Jack Samuels, Tracy Vannorsdall, Phillip Phan
Management Faculty Publications
Objectives This study explores the drug use behaviour in the US general population in the early days of the COVID-19 pandemic with a focus on the relationship between sociopsychological factors, mobility restrictions from March to June 2020 and mental health conditions.
Design A retrospective anonymous online survey representing a cross-section of the US population in 2020.
Setting A qualified panel of 500 000 Qualtrics participants stratified by gender, race, age and geographical region to represent the US population.
Participants 3340 participants voluntarily consented to respond.
Measures Outcome measure for illicit and non-medical use of prescription drugs based on the National …
Should The X-Minute City Include Commutes? An Evaluation Using Commute And Well-Being Data From The Singapore Life Panel®, Sock Yong Phang, Yen Cong Wong, Stephen Hoskins
Should The X-Minute City Include Commutes? An Evaluation Using Commute And Well-Being Data From The Singapore Life Panel®, Sock Yong Phang, Yen Cong Wong, Stephen Hoskins
Research Collection School Of Economics
Over the past decade, the x-minute city — or “chrono-urbanism” — has gained traction intransport planning, emphasizing residents’ ability to access essential destinations within15-min travel time from their homes. Some cities, including Sydney and Singapore, haveextended this concept to commuting, with Singapore’s Land Transport Authority targetinga “45-min city” for daily commutes by 2040. While well-intentioned, applying time-basedgoals to commuting remains controversial. This study evaluates the validity of thex-minute commute city as a transport planning objective by examining the link betweencommuting duration and well-being. Using high-frequency panel data from 2,535Singapore residents aged 55 to 75, we analyze how commuting affects life …
Woa-Covid-19: Whale Optimization Algorithm For Selection Of Multi-Examination Features Based On Covid-19 Infections, Karrar Hameed Abdulkareem, Mazin Abed Mohammed, Zaid Abdi Alkareem Alyasseri, Dawood Zahi Khutar, Osama Ahmad Alomari
Woa-Covid-19: Whale Optimization Algorithm For Selection Of Multi-Examination Features Based On Covid-19 Infections, Karrar Hameed Abdulkareem, Mazin Abed Mohammed, Zaid Abdi Alkareem Alyasseri, Dawood Zahi Khutar, Osama Ahmad Alomari
Mesopotamian Journal of Computer Science
Since its emergence in late 2019, COVID-19 (Coronavirus Disease 2019) has become one of the most critical global health threats, claiming millions of lives and placing many more at serious risk. The complexity of diagnosing COVID-19 lies in the wide range of clinical and examination features involved, prompting researchers to explore various advanced diagnostic methods. However, one of the main challenges is identifying the most relevant features that can streamline and improve diagnostic accuracy. In this study, we propose a feature selection approach based on the Whale Optimization Algorithm (WOA) to identify key examination indicators associated with COVID-19. We used …
Exploring The Lived Experiences Of Chronic Absenteeism Among Undergraduate Students At A Historically Black University: An Interpretative Phenomenological Analysis, Patrick Whitehead, Ronald Leonhardt, Malisha Mishoe, Dorene Medlin, Emily Woodruff, George Darrisaw
Exploring The Lived Experiences Of Chronic Absenteeism Among Undergraduate Students At A Historically Black University: An Interpretative Phenomenological Analysis, Patrick Whitehead, Ronald Leonhardt, Malisha Mishoe, Dorene Medlin, Emily Woodruff, George Darrisaw
School of Social Work Faculty Publications and Presentations
This research examines chronic absenteeism at an American public, historically Black university. Chronic absenteeism, which became a problem during and following the COVID-19 pandemic, has contributed to rising failure rates and a 34% graduation-to-retention rate among students. Using the interpretative phenomenological analysis (IPA) method, the authors, who are college instructors, interviewed 13 students with histories of absenteeism. Student cases were analyzed separately and together to identify relevant absenteeism themes. Significant themes include life conflicts (such as a flat tire or illness), lack of perceived relevance of courses (such as courses that fall outside of a student's major), and lack of …
Gender-Sexuality Alliance Advisors’ Covid-19 Strategies Inform Future Responses To Sociopolitical Crises, Robert A. Marx, Michael O’Brien, Megan K. Yang, Diana Smith, V. Paul Poteat
Gender-Sexuality Alliance Advisors’ Covid-19 Strategies Inform Future Responses To Sociopolitical Crises, Robert A. Marx, Michael O’Brien, Megan K. Yang, Diana Smith, V. Paul Poteat
Faculty Research, Scholarly, and Creative Activity
In the spring of 2020, the COVID-19 pandemic necessitated a sudden shift to remote learning in schools across the United States, profoundly impacting marginalized communities, including LGBTQ+ students. This qualitative study explores the experiences of Gender and Sexuality Alliance (GSA) advisors during this period. Drawing on interviews with 10 GSA advisors, the research highlights the structural and logistical challenges faced, such as limited access to technology and virtual-meeting fatigue, as well as the innovative solutions and adaptations made to continue supporting LGBTQ+ youth. The study reveals how GSAs leveraged existing resources, maintained group cohesion, and adjusted meeting structures to navigate …
Sex Work And Covid-19: An Intersectional Discussion Of U.S.-Based Sex Worker Experiences During The Pandemic, Sabrina M. Grandia
Sex Work And Covid-19: An Intersectional Discussion Of U.S.-Based Sex Worker Experiences During The Pandemic, Sabrina M. Grandia
Cal Poly Humboldt theses and projects
The COVID-19 pandemic impacted all forms of industry, including that of sex work. Between October 2020 until November 2022, I did field research and interviews with nine U.S.-based sex workers throughout those months of the pandemic. Using a grounded theory approach, I asked open-ended questions about their entrance into the industry, business practices, and personal experiences before and during the pandemic. Their stories allow us to gain insight into the impact the pandemic had on them as individuals and their broader communities. My analysis highlights a prominent influence of anti-trafficking policy, politicization of the virus, and the impact of Black …
Sars-Cov-2 Genomic Surveillance Using Self-Collected Saliva Specimens During Occupational Testing Programs, Andy T. Schnaubelt, David Brett-Major, Janet Williamson, Bailey Barcal, Julie Carstens, Ashley Peer, Michael R. Wiley, M. Jana Broadhurst
Sars-Cov-2 Genomic Surveillance Using Self-Collected Saliva Specimens During Occupational Testing Programs, Andy T. Schnaubelt, David Brett-Major, Janet Williamson, Bailey Barcal, Julie Carstens, Ashley Peer, Michael R. Wiley, M. Jana Broadhurst
Journal Articles: Epidemiology
Continually emerging SARS-CoV-2 variants pose challenges to clinical and public health interventions, necessitating sustainable approaches to real-time variant monitoring. This case study describes an innovative SARS-CoV-2 screening and surveillance program that demonstrates the utility of sequencing-based variant monitoring using self-collected saliva specimens. We conducted saliva-based SARS-CoV-2 screening in occupational settings in Omaha, Nebraska from December 2021 through November 2022. 8,372 saliva specimens collected from 1,480 participants were tested for SARS-CoV-2 RNA by extraction-free PCR, with 334 positive samples referred for whole-genome sequencing analysis. Program utilization, quality metrics, and sequencing outputs were compared across sites. Specimen quality was high across program …
The Development Of A One Pot, Two Reaction Synthetic Preparation Of 1,2,4-Oxadiazole, And Synthesis Of Ataluren, A Novel Drug In The Fight Against Duchenne Muscular Dystrophy. Efforts Towards The Synthesis Of A Potential Protease Inhibitor Against The Main Protease (3clpro) Of Covid-19, Austin J. Carter
Theses and Dissertations
1,2,4-Oxadiazoles are five-membered heterocyclic structures first synthesized by Tiemann and Krüger in 1884. Recent discoveries suggest an array of useful biological properties.In preparation of 1,2,4-oxadiazoles, the most prevalent precursors are amidoximes, which can be created via the reaction of nitriles with hydroxylamine hydrochloride and a base. The amidoximes are reacted with an activated carboxylic acid to yield an acylated intermediate. This intermediate can be exposed to a base to cyclize into the 1,2,4-oxadiazole. This thesis describes the efforts in combining these three steps into a unified one-pot synthesis.
Currently, there are a significant number of commercially available FDA approved and …
The Impact Of Covid-19 Pandemic Demands On By-Law Officer Wellness And Work, Harveen Randhawa
The Impact Of Covid-19 Pandemic Demands On By-Law Officer Wellness And Work, Harveen Randhawa
Theses and Dissertations (Comprehensive)
This research sheds light on how the rapid demand to enforce transitioning pandemic-related (and reopening) mandates impacts the wellness of bylaw officers in the context of resource strain. Ontario bylaw officers are at the forefront of the province’s response, enforcing lockdown rules to ensure community safety. This research is imperative in understanding how bylaw officers maintain their roles in municipal enforcement, while enforcing rapidly shifting COVID-19 regulations and moving forward into a post-lockdown climate. The research focuses on identifying and understanding the demands and resources that currently typify bylaw officers working in Southern Ontario. It further examines how the COVID-19 …
Quantitatively Assessing The Impact Of The Quality Of Snomed Ct Subtype Hierarchy On Cohort Queries, Xubing Hao, Xiaojin Li, Yan Huang, Jay Shi, Rashmie Abeysinghe, Cui Tao, Kirk Roberts, Guo-Qiang Zhang, Licong Cui
Quantitatively Assessing The Impact Of The Quality Of Snomed Ct Subtype Hierarchy On Cohort Queries, Xubing Hao, Xiaojin Li, Yan Huang, Jay Shi, Rashmie Abeysinghe, Cui Tao, Kirk Roberts, Guo-Qiang Zhang, Licong Cui
Faculty, Staff and Student Publications
Objective: SNOMED CT provides a standardized terminology for clinical concepts, allowing cohort queries over heterogeneous clinical data including Electronic Health Records (EHRs). While it is intuitive that missing and inaccurate subtype (or is-a) relations in SNOMED CT reduce the recall and precision of cohort queries, the extent of these impacts has not been formally assessed. This study fills this gap by developing quantitative metrics to measure these impacts and performing statistical analysis on their significance.
Material and methods: We used the Optum de-identified COVID-19 Electronic Health Record dataset. We defined micro-averaged and macro-averaged recall and precision metrics to assess the …
Empathy Unmasked: Patient Perception Of Physician Empathy In An Oncologic Emergency Setting A Randomized Controlled Trial Comparing Personal Protective Equipment Wear Versus Unmasked Video Communication, Kathryn J Burk, John J Stroh, Kelly Larkin, Patrick Chaftari, Denise M Langabeer, Jazmin R Menendez, Jeanie F Woodruff, Jan Hargrave, Hongxu Zhu, James P Long, Sai-Ching J Yeung, Kumar Alagappan, Aiham Qdaisat
Empathy Unmasked: Patient Perception Of Physician Empathy In An Oncologic Emergency Setting A Randomized Controlled Trial Comparing Personal Protective Equipment Wear Versus Unmasked Video Communication, Kathryn J Burk, John J Stroh, Kelly Larkin, Patrick Chaftari, Denise M Langabeer, Jazmin R Menendez, Jeanie F Woodruff, Jan Hargrave, Hongxu Zhu, James P Long, Sai-Ching J Yeung, Kumar Alagappan, Aiham Qdaisat
Faculty, Staff and Student Publications
Background: Amidst the COVID-19 pandemic, telemedicine emerged as an important option that supports and facilitates clinical practice, however, its usefulness in emergency settings that treat patients with cancer is unclear.
Objective: To evaluate patient perception of physician empathy in an emergency oncology setting, comparing video interaction to an in-person with personal protective equipment (PPE) approach.
Methods: In this single-center, prospective, cross-sectional, survey-based randomized controlled trial, patients were randomized 1:1 for the concluding conversation done in-person which included either interacting with physicians wearing PPE or video interaction with physicians without PPE (virtual). Patients' perceptions of the physicians' relational empathy were assessed …
Placentas From Sars-Cov-2 Infection During Pregnancy Exhibit Foci Of Oxidative Stress And Dna Damage, Guilherme M Nobrega, Eliza R Mccoll, Arthur Antolini-Tavares, Renato T Souza, José Guilherme Cecatti, Maria Laura Costa, Indira U Mysorekar
Placentas From Sars-Cov-2 Infection During Pregnancy Exhibit Foci Of Oxidative Stress And Dna Damage, Guilherme M Nobrega, Eliza R Mccoll, Arthur Antolini-Tavares, Renato T Souza, José Guilherme Cecatti, Maria Laura Costa, Indira U Mysorekar
Faculty, Staff and Students Publications
Problem: COVID-19 during pregnancy is linked to increased maternal morbidity and a higher incidence of preterm births (PTBs), yet the underlying mechanisms remain unclear. Cellular senescence, characterized by the irreversible cessation of cell division, is a critical process in placental function, and its dysregulation has been implicated in pregnancy complications like PTB. Senescence can be induced by various stressors, including oxidative stress, DNA damage, and viral infections.
Method of study: In this study, we determined whether COVID-19 had an impact on placental senescence. We examined placentas from women infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (n = 10 …
Long-Term Mortality Following Sars-Cov-2 Infection In Rural Versus Urban Dwellers With Autoimmune Or Inflammatory Rheumatic Disease: A Retrospective Cohort Analysis From The National Covid Cohort Collaborative, A Jerrod Anzalone, Lesley E Jackson, Namrata Singh, Maria I Danila, Elizabeth Reisher, Rena C Patel, Jasvinder A Singh
Long-Term Mortality Following Sars-Cov-2 Infection In Rural Versus Urban Dwellers With Autoimmune Or Inflammatory Rheumatic Disease: A Retrospective Cohort Analysis From The National Covid Cohort Collaborative, A Jerrod Anzalone, Lesley E Jackson, Namrata Singh, Maria I Danila, Elizabeth Reisher, Rena C Patel, Jasvinder A Singh
Faculty, Staff and Students Publications
Objective: Autoimmune or inflammatory rheumatic diseases (AIRDs) increase the risk for poor COVID-19 outcomes. Although rurality is associated with higher post-COVID-19 mortality in the general population, whether rurality elevates this risk among people with AIRD is unknown. We assessed associations between rurality and post-COVID-19 all-cause mortality, up to two years post infection, among people with AIRD using a large nationally sampled US cohort.
Methods: This retrospective study used the National COVID Cohort Collaborative, a medical records repository containing COVID-19 patient data. We included adults with two or more AIRD diagnostic codes and a COVID-19 diagnosis documented between April 2020 and …
Incorporating Individually Defined Brain Health Priorities In Clinical Trial Outcomes: The Electronic Person-Specific Outcome Measure Approach In The United States, Stina Saunders, Ali Jannati, Shane Sheehan, Claudio Toro-Serey, Sean Tobyne, Killian Mcmanus, David Bates, John Showalter, Álvaro Pascual-Leone
Incorporating Individually Defined Brain Health Priorities In Clinical Trial Outcomes: The Electronic Person-Specific Outcome Measure Approach In The United States, Stina Saunders, Ali Jannati, Shane Sheehan, Claudio Toro-Serey, Sean Tobyne, Killian Mcmanus, David Bates, John Showalter, Álvaro Pascual-Leone
Faculty, Staff and Students Publications
Introduction: While a limited number of disease-modifying treatments for Alzheimer's disease (AD) have been approved in the United States, there is caution in adopting these treatments in clinical use. The electronic Person-Specific Outcome Measure (ePSOM) tool was recently developed to establish whether, besides modifying underlying AD pathology, new treatments exerted sufficient beneficial effects in areas that matter the most to an individual.
Methods: We conducted a study to understand how findings from the ePSOM UK study applied in the United States. The ePSOM US survey (May 2023 to January 2024) collected primarily free-text responses in personally defined brain health priorities, …
Baseline Predictors For 28-Day Covid-19 Severity And Mortality Among Hospitalized Patients: Results From The Impacc Study, Jintong Hou, Benjamin Haslund-Gourley, Joann Diray-Arce, Annmarie Hoch, Nadine Rouphael, Patrice M Becker, Alison D Augustine, Al Ozonoff, Leying Guan, Steven H Kleinstein, Bjoern Peters, Elaine Reed, Matt Altman, Charles R Langelier, Holden Maecker, Seunghee Kim, Ruth R Montgomery, Florian Krammer, Michael Wilson, Walter Eckalbar, Steven E Bosinger, Ofer Levy, Hanno Steen, Lindsey B Rosen, Lindsey R Baden, Esther Melamed, Lauren I R Ehrlich, Grace A Mccomsey, Rafick P Sekaly, Joanna Schaenman, Albert C Shaw, David A Hafler, David B Corry, Farrah Kheradmand, Mark A Atkinson, Scott C Brakenridge, Nelson I Agudelo Higuita, Jordan P Metcalf, Catherine L Hough, William B Messer, Bali Pulendran, Kari C Nadeau, Mark M Davis, Ana Fernandez Sesma, Viviana Simon, Monica Kraft, Chris Bime, Carolyn S Calfee, David J Erle, Impacc Network, Lucy F Robinson, Charles B Cairns, Elias K Haddad, Mary Ann Comunale
Baseline Predictors For 28-Day Covid-19 Severity And Mortality Among Hospitalized Patients: Results From The Impacc Study, Jintong Hou, Benjamin Haslund-Gourley, Joann Diray-Arce, Annmarie Hoch, Nadine Rouphael, Patrice M Becker, Alison D Augustine, Al Ozonoff, Leying Guan, Steven H Kleinstein, Bjoern Peters, Elaine Reed, Matt Altman, Charles R Langelier, Holden Maecker, Seunghee Kim, Ruth R Montgomery, Florian Krammer, Michael Wilson, Walter Eckalbar, Steven E Bosinger, Ofer Levy, Hanno Steen, Lindsey B Rosen, Lindsey R Baden, Esther Melamed, Lauren I R Ehrlich, Grace A Mccomsey, Rafick P Sekaly, Joanna Schaenman, Albert C Shaw, David A Hafler, David B Corry, Farrah Kheradmand, Mark A Atkinson, Scott C Brakenridge, Nelson I Agudelo Higuita, Jordan P Metcalf, Catherine L Hough, William B Messer, Bali Pulendran, Kari C Nadeau, Mark M Davis, Ana Fernandez Sesma, Viviana Simon, Monica Kraft, Chris Bime, Carolyn S Calfee, David J Erle, Impacc Network, Lucy F Robinson, Charles B Cairns, Elias K Haddad, Mary Ann Comunale
Faculty, Staff and Students Publications
Introduction: The coronavirus disease 2019 (COVID-19) pandemic threatened public health and placed a significant burden on medical resources. The Immunophenotyping Assessment in a COVID-19 Cohort (IMPACC) study collected clinical, demographic, blood cytometry, serum receptor-binding domain (RBD) antibody titers, metabolomics, targeted proteomics, nasal metagenomics, Olink, nasal viral load, autoantibody, SARS-CoV-2 antibody titers, and nasal and peripheral blood mononuclear cell (PBMC) transcriptomics data from patients hospitalized with COVID-19. The aim of this study is to select baseline biomarkers and build predictive models for 28-day in-hospital COVID-19 severity and mortality with most predictive variables while prioritizing routinely collected variables.
Methods: We analyzed 1102 …
Design And Rationale Of Myoflame-19 Randomised Controlled Trial: Myocardial Protection To Reduce Post-Covid Inflammatory Heart Disease Using Cardiovascular Magnetic Resonance Endpoints, Valentina O Puntmann, Dietrich Beitzke, Andreas Kammerlander, Inga Voges, Dominik D Gabbert, Marcus Doerr, Bishwas Chamling, Biykem Bozkurt, Juan Carlos Kaski, Erica Spatz, Eva Herrmann, Gernot Rohde, Philipp Deleuw, Lenka Taylor, Christine Windemuth-Kieselbach, Cornelia Harz, Marta Santiuste, Laura Schoeckel, Juliana Hirayama, Peter C Taylor, Colin Berry, Eike Nagel
Design And Rationale Of Myoflame-19 Randomised Controlled Trial: Myocardial Protection To Reduce Post-Covid Inflammatory Heart Disease Using Cardiovascular Magnetic Resonance Endpoints, Valentina O Puntmann, Dietrich Beitzke, Andreas Kammerlander, Inga Voges, Dominik D Gabbert, Marcus Doerr, Bishwas Chamling, Biykem Bozkurt, Juan Carlos Kaski, Erica Spatz, Eva Herrmann, Gernot Rohde, Philipp Deleuw, Lenka Taylor, Christine Windemuth-Kieselbach, Cornelia Harz, Marta Santiuste, Laura Schoeckel, Juliana Hirayama, Peter C Taylor, Colin Berry, Eike Nagel
Faculty, Staff and Students Publications
Background: Cardiac symptoms due to postacute inflammatory cardiac involvement affect a broad segment of previously well people with only mild acute coronavirus disease 2019 (COVID-19) illness and without overt structural heart disease. Cardiovascular magnetic resonance (CMR) imaging can identify the underlying subclinical disease process, which is associated with chronic cardiac symptoms. Specific therapy directed at reducing postacute cardiac inflammatory involvement before development of myocardial injury and impairment is missing.
Methods: Prospective multicenter randomized placebo-controlled study of myocardial protection therapy (combined immunosuppressive/antiremodeling) of low-dose prednisolone and losartan. Consecutive symptomatic individuals with a prior COVID-19 infection, no pre-existing significant comorbidities or structural …
Heterologous Prime-Pull Mucosal Vaccination With An Adjuvanted Rbd Vaccine Elicits Robust Iga Production And Protects Against Sars-Cov-2, Allyson H Hirsch, Calder R Ellsworth, William A Lewis, Ryan Craig, Amy E Meyer, Jonatan Maldonado, Frania Ramirez Lopez, Syamala Rani Thimmiraju, James B Mclachlan, Xuebin Qin, Nicholas J Maness, Jeroen Pollet, Ulrich Strych, Maria Elena Bottazzi, Peter J Hotez, Lisa A Morici
Heterologous Prime-Pull Mucosal Vaccination With An Adjuvanted Rbd Vaccine Elicits Robust Iga Production And Protects Against Sars-Cov-2, Allyson H Hirsch, Calder R Ellsworth, William A Lewis, Ryan Craig, Amy E Meyer, Jonatan Maldonado, Frania Ramirez Lopez, Syamala Rani Thimmiraju, James B Mclachlan, Xuebin Qin, Nicholas J Maness, Jeroen Pollet, Ulrich Strych, Maria Elena Bottazzi, Peter J Hotez, Lisa A Morici
Faculty, Staff and Students Publications
Despite the efficacy of approved severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines in preventing severe disease and death, breakthrough infections continue to occur in vaccinated individuals, contributing to further viral mutation and spread. These limitations may be attributable to the poor induction of mucosal immunity by parenteral vaccination. Mucosal adjuvants, such as T-vant, can enhance vaccine-induced immune responses through the generation of antigen-specific antibodies and T cells in the respiratory tract. In this study, we evaluated the protective efficacy of adjuvanted SARS-CoV-2 receptor binding domain (RBD) subunit vaccines administered by homologous and heterologous routes. Immunized mice were challenged with …
Tracing The Impact Of Covid-19 On Early Language And Literacy Development From Pre-K Through First Grade, Elizabeth Hadley, Siyu Liu, Eunsook Kim, Meaghan Mckenna, Katharine Hull
Tracing The Impact Of Covid-19 On Early Language And Literacy Development From Pre-K Through First Grade, Elizabeth Hadley, Siyu Liu, Eunsook Kim, Meaghan Mckenna, Katharine Hull
Language, Literacy, Ed.D., Exceptional Education, and Physical Education Faculty Publications
COVID-19 disrupted early educational experiences for a generation of children, but research on how missing school impacted academic development for young children is limited. This paper investigated the longitudinal impact of COVID-19 on the language and literacy development of children in a Florida school district, specifically following children who were in pre-K in March 2020 through the end of first grade. This COVID-19 cohort (n = 1,167) was compared with a pre-COVID-19 cohort (n = 1,211) using propensity score matching, multilevel regression models, and linear growth modeling. Results indicated that the negative impacts of COVID-19 on language and literacy emerged …
Platypnea-Orthodeoxia And Patent Foramen Ovale In A Patient In The Setting Of Covid-19, Laura Sarmiento, Riyad Kherallah, Guilherme Vianna Silva
Platypnea-Orthodeoxia And Patent Foramen Ovale In A Patient In The Setting Of Covid-19, Laura Sarmiento, Riyad Kherallah, Guilherme Vianna Silva
The Texas Heart Institute Journal
Platypnea-orthodeoxia syndrome is a rare condition characterized by positional dyspnea and hypoxemia, with symptoms presenting in the upright position and improving when recumbent. Hypoxemia in platypnea-orthodeoxia syndrome is defined as a drop in Pao
No Evidence Of Mmr Induced Trained Immunity To Prevent Sars Cov2: Results From A Multi-Centre Rct, Sinead Delany-Moretlwe, George Kyei, Erik Dubberke, Linda Yun, Leon Du Toit, Mary Politi, Ben Swan, Anne Deschryver, Sherry Mckinnon, Ananya Gupta, Shabaana Khader, Michael S Avidan, Et Al.
No Evidence Of Mmr Induced Trained Immunity To Prevent Sars Cov2: Results From A Multi-Centre Rct, Sinead Delany-Moretlwe, George Kyei, Erik Dubberke, Linda Yun, Leon Du Toit, Mary Politi, Ben Swan, Anne Deschryver, Sherry Mckinnon, Ananya Gupta, Shabaana Khader, Michael S Avidan, Et Al.
2020-Current year OA Pubs
BACKGROUND: Measles-containing vaccines (MCV), by training innate immune cells, are hypothesized to prevent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and coronavirus disease 2019 (COVID-19).
METHODS: In this international, double-blind, placebo-controlled trial, we randomly assigned adults, 18 years and older, to receive MCV or saline. The primary outcome was polymerase chain reaction (PCR) confirmed symptomatic COVID-19, up to 60 days after intervention. Secondary outcomes were PCR-confirmed symptomatic COVID-19 and serologically confirmed SARS-CoV-2 infection, up to 150 days after intervention.
RESULTS: Of 3411 randomised participants, the modified intention-to-treat population included 1607 in the MCV and 1545 in the saline group. …
Hubungan Antara Hipertensi Dan Kematian Pasien Covid-19 Di Layanan Rawat Inap Rsud Tarakan Tahun 2022 (Association Between Hypertension And Mortality Of Covid-19 Inpatients At Tarakan Regional General Hospital In 2022), Karina Widyasari, Mondastri Korib Sudaryo
Hubungan Antara Hipertensi Dan Kematian Pasien Covid-19 Di Layanan Rawat Inap Rsud Tarakan Tahun 2022 (Association Between Hypertension And Mortality Of Covid-19 Inpatients At Tarakan Regional General Hospital In 2022), Karina Widyasari, Mondastri Korib Sudaryo
Jurnal Epidemiologi Kesehatan Indonesia
Coronavirus Disease 2019 (COVID-19) is an infectious disease caused by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). COVID-19 was the leading disease in terms of the highest number of hospital admissions and cause of death at the Tarakan Regional General Hospital (RSUD Tarakan) in 2022. COVID-19 patients who received treatment at the hospital were often individuals with underlying conditions, such as hypertension. Therefore, it is important to conduct research on comorbidities, specifically hypertension, and its relationship to COVID-19 mortality at the RSUD Tarakan’s inpatient in 2022, so the hospital can design spesific care plans for COVID-19 patients with hypertension. …
Double-Blind Randomised Trial Of Saline Solution For Gargling And Nasal Rinsing In Sars-Cov-2 Infection, Sebastian R Espinoza, Lexton Trauffler, Amir Shamshirsaz, Alireza Shamshirsaz, Andres Espinoza, Jimmy Espinoza, Alice O'Brien
Double-Blind Randomised Trial Of Saline Solution For Gargling And Nasal Rinsing In Sars-Cov-2 Infection, Sebastian R Espinoza, Lexton Trauffler, Amir Shamshirsaz, Alireza Shamshirsaz, Andres Espinoza, Jimmy Espinoza, Alice O'Brien
Faculty, Staff and Student Publications
Background: Previous studies have shown that hypertonic saline nasal irrigation and gargling reduced the duration of symptoms in upper respiratory infections caused by coronavirus. This study aims to investigate the effects of two saline regimens on symptoms associated with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2).
Methods: Between 2020 and 2022, individuals aged 18-65 years who tested positive for SARS-CoV-2 infection via polymerase chain reaction (PCR) were randomly assigned to either low- or high-saline regimens for 14 days. The low-saline solutions contained 2.13 g of salt dissolved in eight ounces of warm water, while the high-saline solution contained six grams of …
The Experiences Of Nurses Caring For Patients During The Initial Outbreak Of The Covid-19 Pandemic In The Maldives: A Phenomenological Study, Khadiyya Simany, Asiya Ibrahim
The Experiences Of Nurses Caring For Patients During The Initial Outbreak Of The Covid-19 Pandemic In The Maldives: A Phenomenological Study, Khadiyya Simany, Asiya Ibrahim
Manipal Journal of Nursing and Health Sciences
The experience of nurses caring for patients with COVID-19 in the Maldives may have been unique and at the same time similar to the global nursing situation during the initial outbreak of the COVID-19 pandemic. This research aimed to explore nurses’ experiences in providing nursing care for COVID-19 patients in one of the facilities in the Maldives. A descriptive phenomenological approach of inquiry was employed to explore the new phenomenon of the nursing experience during the early COVID-19 pandemic. Using purposive convenience sampling, six nurses were interviewed in depth via semi-structured face‒to-face interviews. The interviews were analysed through modified principles …
Understanding Women, Infant And Children Feeding Decisions In Emergencies: The Case Of Covid-19 And The Formula Shortage, Davida Mensah, Edmund F. Agyemang, Constance Gewa
Understanding Women, Infant And Children Feeding Decisions In Emergencies: The Case Of Covid-19 And The Formula Shortage, Davida Mensah, Edmund F. Agyemang, Constance Gewa
School of Mathematical & Statistical Sciences Faculty Publications
Background: The advantages of breastfeeding and its role in emergencies are undeniable. Studies show that many women in developed countries choose formula over breastmilk, even in emergencies. Nevertheless, no one knows if postpartum women under the Women, Infants and Children (WIC) program turned out to breastfeed or re-lactate their infants during these crises. This study aims to better understand WIC participants' perceptions about breastfeeding their babies in emergencies.
Methods: A chi-square test of independence was used to assess the association between breastfeeding choice and demographic characteristics and potential covariates of respondents. A post hoc analysis using Dunn's multiple comparisons test …
An Intelligent System Using Deep Learning For Healthcare Monitoring In Light Of The Covid-19 And Future Pandemics Based On Iot, Sara Salman Qasim, Rajaa J. Khanjar, Jamal Nasir Hasoon, Baesher Abdullateff Abad, Ali Hussein Fadil, Shajan.M. Alsowaidi
An Intelligent System Using Deep Learning For Healthcare Monitoring In Light Of The Covid-19 And Future Pandemics Based On Iot, Sara Salman Qasim, Rajaa J. Khanjar, Jamal Nasir Hasoon, Baesher Abdullateff Abad, Ali Hussein Fadil, Shajan.M. Alsowaidi
Al-Esraa University College Journal for Engineering Sciences
Recently, the Internet of Things has become a compelling research field as a new topic of research in various disciplines, particularly in the field of healthcare, because the Internet of Things is rebuilding modern healthcare systems by integrating technology, economics, and social perspectives. The development of healthcare systems from traditional to more personalized systems in which patients can be easily diagnosed, monitored and treated and many people can be helped. People are treated and cared for remotely and this is what some people need in the crisis the world has been through like COVID-19. This epidemic is caused by the …