Digital Commons Network^™

Longitudinal Host Transcriptional Responses To Sars-Cov-2 Infection In Adults With Extremely High Viral Load, Vasanthi Avadhanula, Chad J Creighton, Laura Ferlic-Stark, Divya Nagaraj, Yiqun Zhang, Richard Sucgang, Erin G Nicholson, Anubama Rajan, Vipin Kumar Menon, Harshavardhan Doddapaneni, Donna Marie Muzny, Ginger A Metcalf, Sara Joan Javornik Cregeen, Kristi Louise Hoffman, Richard A Gibbs, Joseph F Petrosino, Pedro A Piedra

Faculty, Staff and Students Publications

Current understanding of viral dynamics of SARS-CoV-2 and host responses driving the pathogenic mechanisms in COVID-19 is rapidly evolving. Here, we conducted a longitudinal study to investigate gene expression patterns during acute SARS-CoV-2 illness. Cases included SARS-CoV-2 infected individuals with extremely high viral loads early in their illness, individuals having low SARS-CoV-2 viral loads early in their infection, and individuals testing negative for SARS-CoV-2. We could identify widespread transcriptional host responses to SARS-CoV-2 infection that were initially most strongly manifested in patients with extremely high initial viral loads, then attenuating within the patient over time as viral loads decreased. Genes …

Baseline Predictors For 28-Day Covid-19 Severity And Mortality Among Hospitalized Patients: Results From The Impacc Study, Jintong Hou, Benjamin Haslund-Gourley, Joann Diray-Arce, Annmarie Hoch, Nadine Rouphael, Patrice M Becker, Alison D Augustine, Al Ozonoff, Leying Guan, Steven H Kleinstein, Bjoern Peters, Elaine Reed, Matt Altman, Charles R Langelier, Holden Maecker, Seunghee Kim, Ruth R Montgomery, Florian Krammer, Michael Wilson, Walter Eckalbar, Steven E Bosinger, Ofer Levy, Hanno Steen, Lindsey B Rosen, Lindsey R Baden, Esther Melamed, Lauren I R Ehrlich, Grace A Mccomsey, Rafick P Sekaly, Joanna Schaenman, Albert C Shaw, David A Hafler, David B Corry, Farrah Kheradmand, Mark A Atkinson, Scott C Brakenridge, Nelson I Agudelo Higuita, Jordan P Metcalf, Catherine L Hough, William B Messer, Bali Pulendran, Kari C Nadeau, Mark M Davis, Ana Fernandez Sesma, Viviana Simon, Monica Kraft, Chris Bime, Carolyn S Calfee, David J Erle, Impacc Network, Lucy F Robinson, Charles B Cairns, Elias K Haddad, Mary Ann Comunale

Faculty, Staff and Students Publications

Introduction: The coronavirus disease 2019 (COVID-19) pandemic threatened public health and placed a significant burden on medical resources. The Immunophenotyping Assessment in a COVID-19 Cohort (IMPACC) study collected clinical, demographic, blood cytometry, serum receptor-binding domain (RBD) antibody titers, metabolomics, targeted proteomics, nasal metagenomics, Olink, nasal viral load, autoantibody, SARS-CoV-2 antibody titers, and nasal and peripheral blood mononuclear cell (PBMC) transcriptomics data from patients hospitalized with COVID-19. The aim of this study is to select baseline biomarkers and build predictive models for 28-day in-hospital COVID-19 severity and mortality with most predictive variables while prioritizing routinely collected variables.

Methods: We analyzed 1102 …

Placentas From Sars-Cov-2 Infection During Pregnancy Exhibit Foci Of Oxidative Stress And Dna Damage, Guilherme M Nobrega, Eliza R Mccoll, Arthur Antolini-Tavares, Renato T Souza, José Guilherme Cecatti, Maria Laura Costa, Indira U Mysorekar

Faculty, Staff and Students Publications

Problem: COVID-19 during pregnancy is linked to increased maternal morbidity and a higher incidence of preterm births (PTBs), yet the underlying mechanisms remain unclear. Cellular senescence, characterized by the irreversible cessation of cell division, is a critical process in placental function, and its dysregulation has been implicated in pregnancy complications like PTB. Senescence can be induced by various stressors, including oxidative stress, DNA damage, and viral infections.

Method of study: In this study, we determined whether COVID-19 had an impact on placental senescence. We examined placentas from women infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (n = 10 …

Long-Term Anti-Sars-Cov-2 Antibody Trajectories After Neutralizing Monoclonal Antibody Treatment, Elizabeth S Munroe, Greg A Grandits, Robert C Hyzy, Hallie C Prescott, Thomas W Barrett, Robin L Dewar, Nicole Engen, Anna L Goodman, Timothy J Hatlen, Helene Highbarger, Thomas L Holland, Gareth Hughes, Tomas O Jensen, Muhammad A Khan, Ioannis Kalomenidis, Nayon Kang, Sylvain Laverdure, Prasad Manian, Vidya Menon, Ravi Patel, Srikanth Ramachandruni, Tauseef Rehman, Kathryn Shaw-Saliba, Birgit Thorup Røge, David M Vock, Amy C Weintrob, Barnaby E Young, Anne P Frosch, Strive Network And Therapeutics For Inpatients With Covid-19 (Tico) Study Groups

Faculty, Staff and Students Publications

Background: Neutralizing monoclonal antibodies (nMAbs) have been used to treat COVID-19 and are increasingly being used to treat other infections. However, there is concern that by neutralizing the SARS-CoV-2 virus, nMAbs may decrease the availability of antigens to the immune system, potentially impairing the endogenous polyclonal immune response and decreasing long-term immune protection.

Methods: We compared 28 and 90-day anti-SARS-CoV-2 spike protein neutralization activity and anti-SARS-CoV-2 nucleocapsid response for patients hospitalized with COVID-19 infection randomized to receive nMAbs or placebo in the large platform ACTIV-3/TICO trials. We pooled results from four trials of anti-spike nMAbs. For most tested agents, measurements …

Effects Of Interventions For The Prevention And Management Of Maternal Anemia In The Advent Of The Covid-19 Pandemic: Systematic Review And Meta-Analysis, John Kyalo Muthuka, Diana Kageni Mbari-Fondo, Francis Muchiri Wambura, Kelly Oluoch, Japheth Mativo Nzioki, Everlyn Musanga Nyamar, Rosemary Nabaweesi

Faculty Publications

Background:The COVID-19 pandemic presented many unknowns for pregnant women, with anemia potentially worsening pregnancy outcomes due to multiple factors.

Objective:This review aimed to determine the pooled effect of maternal anemia interventions and associated factors during the pandemic.

Methods:Eligible studies were observational and included reproductive-age women receiving anemia-related interventions during the COVID-19 pandemic. Exclusion criteria comprised non-English publications, reviews, editorials, case reports, studies with insufficient data, sample sizes below 50, and those lacking DOIs. A systematic search of PubMed, Scopus, Embase, Web of Science, and Google Scholar identified articles published between December 2019 and August 2022. Risk of bias was evaluated …

Efektivitas Vaksin Covid-19 Mrna Booster Kedua Pada Tenaga Kesehatan Di Rumah Sakit Umum Pusat Nasional Dr. Cipto Mangunkusumo Dan Faktor Yang Memengaruhinya, Siti Taqwa Fitria Lubis, Sukamto Koesnoe, Evy Yunihastuti, Hamzah Shatri, Teguh Harjono Karjadi, Kuntjoro Harimurti, Ceva Wicaksono Pitoyo, Em Yunir

Jurnal Penyakit Dalam Indonesia

Introduction. The emergence of the Omicron variant during the pandemic had an impact on the effectiveness of the COVID-19 vaccine. The spread of Omicron increased rapidly even in populations that had been vaccinated with booster doses, causing a high incidence of infection. This study aimed to determine the effectiveness and factors related to the effectiveness of the second mRNA booster vaccine as well as antibody levels after the second mRNA booster vaccine in healthcare workers at Cipto Mangunkusumo National General Hospital.

Methods. This study used a cohort design. Total sampling of 271 healthcare workers were obtained from previous …

Long Covid Dan Sistem Kardiovaskular, Muhadi Muhadi, Ivan Mardhi Laksmana

Jurnal Penyakit Dalam Indonesia

Even after nasopharyngeal Polymerase Chain Reaction (PCR) swab investigation revealed no COVID-19 infection, some individuals continue to have long COVID symptoms. According to a research published in 2022, 4.5 – 36.6% of patients had symptoms following a COVID-19 infection more than three months. Long COVID symptoms may impact multiple organ systems, including the cardiovascular system. Chest pain, palpitations, arrhythmia, postural orthostatic tachycardia syndrome, and other symptoms are possible appeared in long COVID. D-Dimer, echocardiography, CT scan, cMRI and other supportive test showed meaningful results. Pharmacological treatment can be given based on the concurrent diagnosis found in patients with long COVID. …

Hubungan Antara Hipertensi Dan Kematian Pasien Covid-19 Di Layanan Rawat Inap Rsud Tarakan Tahun 2022 (Association Between Hypertension And Mortality Of Covid-19 Inpatients At Tarakan Regional General Hospital In 2022), Karina Widyasari, Mondastri Korib Sudaryo

Jurnal Epidemiologi Kesehatan Indonesia

Coronavirus Disease 2019 (COVID-19) is an infectious disease caused by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). COVID-19 was the leading disease in terms of the highest number of hospital admissions and cause of death at the Tarakan Regional General Hospital (RSUD Tarakan) in 2022. COVID-19 patients who received treatment at the hospital were often individuals with underlying conditions, such as hypertension. Therefore, it is important to conduct research on comorbidities, specifically hypertension, and its relationship to COVID-19 mortality at the RSUD Tarakan’s inpatient in 2022, so the hospital can design spesific care plans for COVID-19 patients with hypertension. …

The Experiences Of Nurses Caring For Patients During The Initial Outbreak Of The Covid-19 Pandemic In The Maldives: A Phenomenological Study, Khadiyya Simany, Asiya Ibrahim

Manipal Journal of Nursing and Health Sciences

The experience of nurses caring for patients with COVID-19 in the Maldives may have been unique and at the same time similar to the global nursing situation during the initial outbreak of the COVID-19 pandemic. This research aimed to explore nurses’ experiences in providing nursing care for COVID-19 patients in one of the facilities in the Maldives. A descriptive phenomenological approach of inquiry was employed to explore the new phenomenon of the nursing experience during the early COVID-19 pandemic. Using purposive convenience sampling, six nurses were interviewed in depth via semi-structured face‒to-face interviews. The interviews were analysed through modified principles …

Double-Blind Randomised Trial Of Saline Solution For Gargling And Nasal Rinsing In Sars-Cov-2 Infection, Sebastian R Espinoza, Lexton Trauffler, Amir Shamshirsaz, Alireza Shamshirsaz, Andres Espinoza, Jimmy Espinoza, Alice O'Brien

Faculty, Staff and Student Publications

Background: Previous studies have shown that hypertonic saline nasal irrigation and gargling reduced the duration of symptoms in upper respiratory infections caused by coronavirus. This study aims to investigate the effects of two saline regimens on symptoms associated with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2).

Methods: Between 2020 and 2022, individuals aged 18-65 years who tested positive for SARS-CoV-2 infection via polymerase chain reaction (PCR) were randomly assigned to either low- or high-saline regimens for 14 days. The low-saline solutions contained 2.13 g of salt dissolved in eight ounces of warm water, while the high-saline solution contained six grams of …

Understanding Women, Infant And Children Feeding Decisions In Emergencies: The Case Of Covid-19 And The Formula Shortage, Davida Mensah, Edmund F. Agyemang, Constance Gewa

School of Mathematical & Statistical Sciences Faculty Publications

Background: The advantages of breastfeeding and its role in emergencies are undeniable. Studies show that many women in developed countries choose formula over breastmilk, even in emergencies. Nevertheless, no one knows if postpartum women under the Women, Infants and Children (WIC) program turned out to breastfeed or re-lactate their infants during these crises. This study aims to better understand WIC participants' perceptions about breastfeeding their babies in emergencies.

Methods: A chi-square test of independence was used to assess the association between breastfeeding choice and demographic characteristics and potential covariates of respondents. A post hoc analysis using Dunn's multiple comparisons test …

Impacto De La Pandemia De La Covid-19 En Las Familias De Los Jóvenes Universitarios De Las Poblaciones Rurales Mayas Del Estado De Yucatán, Jorge Atocha Pacheco Castro

Journal of Maya Heritage

Abstract. This study examines the impacts of the COVID-19 pandemic on the families of university students from rural Maya communities in Yucatán, Mexico. Utilizing an anthropological framework, the research highlights the interplay of structural vulnerabilities and cultural resilience. It explores how families navigated economic challenges, social interactions, and cultural practices amid the crisis. Key findings include the reliance on traditional subsistence practices such as small-scale agriculture and backyard farming, which provided a safety net during economic downturns. Socially, rural families reported lower stress levels and stronger communal bonds compared to their urban counterparts, owing to expansive living spaces and outdoor …

Rna Structural-Dynamical Hierarchy: Sars-Cov, Sars-Cov-2, And Delta/Omicron Variant S2m Monomers, Kissing Complexes, And Extended Duplexes, Adam Kensinger

Electronic Theses and Dissertations

The power and promise of ribonucleic acid (RNA) molecules are only beginning to be realized in living organisms and pharmaceutical intervention. Specifically, defining the chemical physics of RNA’s heterogenous structural ensemble and dynamics, which has experienced expansive growth over the last few years, is central to a complete understanding, yet continues to be a significant challenge. A 41-nucleotide hairpin called the stem-loop II motif (s2m), present in the viral genomes of severe acute respiratory syndrome (SARS), SARS-coronavirus-2 (SARS-CoV-2), and the Delta and Omicron variants responsible for the COVID-19 pandemic, is a potential antiviral target due to its high sequence conservation …

Fda Greenlights Early-Stage Trial For Investigational Long Covid Treatment: Phase Ii Evaluation Pending, Arin Wade, Maria Nguyen, Allie Honigford, Kennedy Kosikowski, Minhwan Yang, Rebecca Willier, Joshua Honaker, Samantha Mccord, Theresa Hempleman

Pharmacy and Wellness Review

Long coronavirus disease (COVID) is a condition that affects millions of individuals worldwide. Long COVID manifests as persistent symptoms following acute COVID-19. These symptoms can include, but are not limited to, fatigue, cognitive dysfunction, and chronic inflammation often lasting for months and significantly impairing patients' quality of life. As the number of Long COVID cases continues to rise and major global health organizations begin to standardize Long COVID’s mechanisms and diagnosis, there is an increasing demand for effective treatments that can address its complex nature. While some therapies, such as metformin and hyperbaric oxygen therapy (HBOT) have shown promise in …

Priorities To Care Within The Military Health System: A Mixed Methods Study On Military Spouse Access To Care During Covid-19 On Okinawa, Elayne L. Wilson

Theses & Dissertations

Military spouses in Okinawa experienced denial of care at military treatment facilities and off base Japanese healthcare facilities during the COVID-19 pandemic. Over two years of travel restrictions further contributed to difficulties accessing healthcare while stationed on the island with their active-duty spouse. This study examined the implications of a priority-based access system through the TRICARE program implemented due to limited resources during COVID-19 and its impact on military spouses in a scarce medical resource environment. This concurrent mixed-methods research used a survey tool developed by Community First Hawaii to quantify access to healthcare and in-depth interviews to further explore …

The Impact Of The Virginia Department Of Education On Music Education During The Covid-19 Pandemic, Erica S. Denham

Masters Theses

This research was to identify how the Virginia Department of Education handled Music Education during the COVID-19 pandemic. When proper support from the Department of Education is given, music educators can run their programs efficiently without doing much research on their own. By examining the COVID-19 policies and procedures created by the Virginia Department of Education, this qualitative study investigated how much emphasis was put on the unique needs of an education in music. Therefore, this investigation examined these policies and procedures to note in what ways music education was taken into special consideration. This study explored three distinct phases …

Does Work Arrangement Affect Turnover Intention? Investigating The Mediating Role Of Organizational Trust, Perceived Organizational Support, And Work Locus Of Control, Valerie A. Boyd

Doctoral Dissertations and Projects

Countless U.S. employees were shifted to and from different work arrangements both during and after the COVID-19 pandemic. Though previous research has shown links between workplace factors and organizational outcomes, there is a gap in understanding how different post-pandemic work arrangements and individual differences influence employee work attitudes. This study assessed 315 U.S. employees to investigate the relationship between different work arrangements (WA) and turnover intentions (TI), and the mediating effect of organizational trust (OT), perceived organizational support (POS), and work locus of control (WLC). Eligible participants included full-time U.S. employees over the age of 18 that worked in their …

Dance After Lockdown: Living With Paradox, Simon Ellis, Rowan Mclelland, Rosemary Kostic Cisneros

Kritika Kultura

This writing explores the experiences of people in the UK’s contemporary dance sector during the COVID-19 pandemic.1 It draws on qualitative data from a small research project—Dance after Lockdown—to examine how that sector understands their work, and how the language and ideology of the creative industries have shaped the lives and experiences of contemporary dance artists and institutions in the UK. The paper offers a range of diverse voices as one of the goals of the research was to examine the breadth of experiences, which we hope makes a case for the need to have a dance sector that is …

Covid-19: Kritikal Na Pagsusuri Ng Diskurso Ng Kagawaran Ng Kalusugan Sa Unang Yugto Ng Pandemya Sa Pilipinas, Alona Jumaquio-Ardales, Nathaniel Oco

Kritika Kultura

The paper contributed to the literature of COVID-19 in the Philippines by conducting an interdisciplinary study on the discourse of the Department of Health during the early phase of the pandemic in the country. The frame of Critical Discourse Analysis (CDA), the process of Human Language Technology (HLT), and the concept of Crisis Management (CM) were used in analyzing the press conferences and virtual pressers. There were 56 videos selected from 30 January to 30 May 2020 using the technique of Browsing, Linking, Shortlisting, and Focusing (BLSF). The results of the study showed that: (1) Filipino language was the medium …

Slow And Quick Violence: Illnesses And Injuries In America Is In The Heart, Ling Liu

Kritika Kultura

This article aims to offer a new route into the study of Carlos Bulosan’s America Is in the Heart by going beyond the usual sociocultural focus and turning instead to the material, specifically the illnesses and injuries borne by Filipino bodies—tuberculosis, syphilis, hunger, injuries, even death—to learn about their colonial and migrant experiences. In the novel, tuberculosis affects working-class migrant Filipinos disproportionately in both the Philippines and the United States of America. Migrant Filipinos are also constantly haunted by hunger and are always injured, or even shot; and working-class women frequently die from syphilis. Applying ecocritical theories to study the …

Analysis Of The Longitudinal Effect Of Home Advantage In The Brazilian Football Championship – Série A, Werlayne Leite, Marcelo C. Zanetti

Baltic Journal of Health and Physical Activity

Athletes and teams typically obtain an advantage when competing at home, a phenomenon known as home advantage (HA). This study investigates the longitudinal effect of HA in the Brazilian Football Championship (Série A) over 21 seasons, analyzing 8,405 matches from 2003 to 2023. The results showed that the average HA was 35.1 ± 7.7%, while the competitive balance (CB) was 0.838 ± 0.145. A negative, non-significant correlation (r = -0.321, p = 0.157) was found between HA and CB, with CB explaining 10.3% of HA variation in the Brazilian league. HA de-creased over time, likely due to improved logistics, …

The Burden Mothers Bear: Using The Health Belief Model To Understand How U.S. Mothers’ Intersectional Identities Shape Health Decision-Making During Covid-19, Sydney O'Shay, Kaitlin E. Phillips, Marissa J. Sáez

Publications

The disproportionate impact of COVID-19 on people of color and the burden placed on mothers created a need to better understand how mothers of color made health decisions for their families and communicated these decisions with others during the pandemic. This study investigated how this populations’ intersectional identities played a role in their health decision-making processes and overall experiences during COVID-19. Using the health belief model as a sensitizing concept, we conducted qualitative in-depth interviews with mothers of color across the United States about their lived experiences during the pandemic. Our findings suggest a need for health communicators to address …

Abide With Me: A Social Ecological Perspective In Selected Pandemic Poetry, Amany Abdullah Abdelaziz Eldiasty, Eman Ebeida Mansour

Kritika Kultura

This article traces the core principles of the social ecological approach, namely, the interconnectedness of social communities and their integration into the natural world in selected poems written by contemporary poets during the coronavirus pandemic and collected in Poetry in Response to the Pandemic, published in 2020 by St. Michael’s Episcopal Church in Arlington, VA. Applying a qualitative approach that integrates interpretive and analytical readings of the selected poems based on Daniel Stokols’s views on social ecology, it argues that although social networks facilitated community engagements during the pandemic (particularly during the lockdown), virtual reality failed to sustain the social …

Elevated Ambient Temperature Associated With Reduced Infectious Disease Test Positivity Rates: Retrospective Observational Analysis Of Statewide Covid-19 Testing And Weather Across California Counties., Nicholas Wing-Ping Kwok, Joshua Pevnick, Keith Feldman

Manuscripts, Articles, Book Chapters and Other Papers

BACKGROUND: From medication usage to the time of day, a number of external factors are known to alter human body temperature (BT), even in the absence of underlying pathology. In select cases, clinical guidance already suggests the consideration of clinical and demographic factors when interpreting BT, such as a decreased threshold for fever as age increases. Recent work has indicated factors impacting BT extend to environmental conditions including ambient temperature. However, the effect sizes of these relationships are often small, and it remains unclear if such relationships result in a meaningful impact on real-world health care practices.

OBJECTIVE: Temperature remains …

A Potent Pan-Sarbecovirus Neutralizing Antibody Resilient To Epitope Diversification, Laura E Rosen, Zhuoming Liu, Sean P J Whelan, Et Al.

2020-Current year OA Pubs

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) evolution has resulted in viral escape from clinically authorized monoclonal antibodies (mAbs), creating a need for mAbs that are resilient to epitope diversification. Broadly neutralizing coronavirus mAbs that are sufficiently potent for clinical development and retain activity despite viral evolution remain elusive. We identified a human mAb, designated VIR-7229, which targets the viral receptor-binding motif (RBM) with unprecedented cross-reactivity to all sarbecovirus clades, including non-ACE2-utilizing bat sarbecoviruses, while potently neutralizing SARS-CoV-2 variants since 2019, including the recent EG.5, BA.2.86, and JN.1. VIR-7229 tolerates extraordinary epitope variability, partly attributed to its high binding affinity, …

A Phenomenological Study Exploring The Experiences Of University Faculty Navigating The Diverse Environments Of Remote, Office-Based, Or Hybrid Work, Justen Gross

Doctoral Dissertations and Projects

In this phenomenological qualitative analysis, the experiences of university faculty in diverse environments of remote, office-based, or hybrid work were explored. COVID-19 significantly impacted businesses and organizations' ability to function in the traditional office-based environment based on government restrictions and directives. Office-based work and remote work have been in place for some time. Hybrid work was a relatively new phenomenon that required additional exploration as little was known about hybrid working models. This study explored how diverse work environments, personal factors, social factors, and organizational factors influenced job stress and job satisfaction post-COVID-19 with staff and faculty at a large …

Motivation In The Remote Workplace: Basic Psychological Need Satisfaction During The Covid-19 Pandemic, Nina R. Simmons

Doctoral Dissertations and Projects

Due to their essential role in the promotion of employee and organizational effectiveness, internal processes regulating work motivation have been a topic of interest for decades. Influenced by a need-supportive environment, work motivation is at least partially controlled by the organization. However, employee needs and need satisfaction have been largely addressed in research in traditional work settings, leaving a vastly different work arrangement insufficiently explored: remote work. This holds especially true for involuntary remote work - a viable solution for organizations during a crisis. To address this gap in knowledge, a qualitative descriptive study was conducted to examine basic psychological …

A Trivalent Mucosal Vaccine Encoding Phylogenetically Inferred Ancestral Rbd Sequences Confers Pan-Sarbecovirus Protection In Mice, James Brett Case, Shilpa Sanapala, Suzanne M Scheaffer, Déborah Carolina Carvalho Dos Anjos, Lucas J Adams, Nadia Soudani, Chieh-Yu Liang, Baoling Ying, Adrianus C M Boon, Daved H Fremont, Sean P J Whelan, Michael S Diamond, Et Al.

2020-Current year OA Pubs

The continued emergence of SARS-CoV-2 variants and the threat of future Sarbecovirus zoonoses have spurred the design of vaccines that can induce broad immunity against multiple coronaviruses. Here, we use computational methods to infer ancestral phylogenetic reconstructions of receptor binding domain (RBD) sequences across multiple Sarbecovirus clades and incorporate them into a multivalent adenoviral-vectored vaccine. Mice immunized with this pan-Sarbecovirus vaccine are protected in the upper and lower respiratory tracts against infection by historical and contemporary SARS-CoV-2 variants, SARS-CoV, and pre-emergent SHC014 and Pangolin/GD coronavirus strains. Using genetic and immunological approaches, we demonstrate that vaccine-induced protection unexpectedly is conferred principally …

Cura Communitatis In The Time Of Coronavirus, Jeffrey Labelle

Jesuit Higher Education: A Journal

This study conceptualizes cura communitatis as a contemporary bridge between cura personalis and cura apostolica for Jesuit higher educational institutions. A review of related literature suggests this concept as a possible means for Jesuit IHEs to respond to the realities of the coronavirus pandemic and the psychological, social, spiritual, and economic challenges which have resulted from dealing with this global health crisis. The author surfaces the shared desire in AJCU institutions to care for one another and our shared relationships as pilgrims during a global phenomenon that has demanded physical distancing. The study explores the ways in which this desire …

National Parks For Future Generations?: The Covid-19 Pandemic’S Impacts On National Parks And Tourism, Colin Cummings '25

Student Research

This paper explores the complex relationship between tourism and the environment in U.S. National Parks, with a focus on the impact of the COVID-19 pandemic. It examines how increased visitation affects wildlife, the spread of invasive species, and the overall health of natural ecosystems. The author argues for a shift in public perception of national parks, emphasizing education, community engagement, and a deeper understanding of the interconnectedness of nature to ensure the preservation of these areas for future generations. The paper also discusses the role of park rangers and historical interpretations of wildlife and the environment, as well as the …