Digital Commons Network^™

Igg3 Subclass Antibodies Recognize Antigenically Drifted Influenza Viruses And Sars-Cov-2 Variants Through Efficient Bivalent Binding, Marcus J. Bolton, Jefferson J.S. Santos, Claudia P. Arevalo, Trevor Griesman, Megan Watson, Shuk Hang Li, Paul Bates, Holly Ramage, Patrick C. Wilson, Scott E. Hensley

Department of Microbiology and Immunology Faculty Papers

The constant domains of antibodies are important for effector functions, but less is known about how they can affect binding and neutralization of viruses. Here, we evaluated a panel of human influenza virus monoclonal antibodies (mAbs) expressed as IgG1, IgG2, or IgG3. We found that many influenza virus-specific mAbs have altered binding and neutralization capacity depending on the IgG subclass encoded and that these differences result from unique bivalency capacities of the subclasses. Importantly, subclass differences in antibody binding and neutralization were greatest when the affinity for the target antigen was reduced through antigenic mismatch. We found that antibodies expressed …

A Comprehensive Drosophila Resource To Identify Key Functional Interactions Between Sars-Cov-2 Factors And Host Proteins, Annabel Guichard, Shenzhao Lu, Oguz Kanca, Daniel Bressan, Yan Huang, Mengqi Ma, Sara Sanz Juste, Jonathan C Andrews, Kristy L Jay, Marketta Sneider, Ruth Schwartz, Mei-Chu Huang, Danqing Bei, Hongling Pan, Liwen Ma, Wen-Wen Lin, Ankush Auradkar, Pranjali Bhagwat, Soo Park, Kenneth H Wan, Takashi Ohsako, Toshiyuki Takano-Shimizu, Susan E Celniker, Michael F Wangler, Shinya Yamamoto, Hugo J Bellen, Ethan Bier

Faculty, Staff and Students Publications

Development of effective therapies against SARS-CoV-2 infections relies on mechanistic knowledge of virus-host interface. Abundant physical interactions between viral and host proteins have been identified, but few have been functionally characterized. Harnessing the power of fly genetics, we develop a comprehensive Drosophila COVID-19 resource (DCR) consisting of publicly available strains for conditional tissue-specific expression of all SARS-CoV-2 encoded proteins, UAS-human cDNA transgenic lines encoding established host-viral interacting factors, and GAL4 insertion lines disrupting fly homologs of SARS-CoV-2 human interacting proteins. We demonstrate the utility of the DCR to functionally assess SARS-CoV-2 genes and candidate human binding partners. We show that …

Finding Data Pathways Through The ‘Pandemic Pilgrimage Boom’: Embedded-Like Research, Covid-19, And The British Pilgrimage Trust, Eleanor O’Keeffe

International Journal of Religious Tourism and Pilgrimage

This article reviews claims that the United Kingdom experienced a ‘pandemic pilgrimage boom’. It contributes findings from an ‘embedded-like’ research project, which drew on data created by the British Pilgrimage Trust (BPT) – a heritage and wellbeing charity that hosts a website hub to support pilgrimage action in the UK – to debate about the impact of COVID-19 on pilgrimage practice. These findings show how a set of uses and meanings about pilgrimage, particularly its affordances for mental health and emotional wellbeing, have resonated during the pandemic, especially at moments of heightened social stress. This has generated greater social traction …

Understanding Risk Perception And Xenophobic Attitudes During The Coronavirus Disease 2019 (Covid-19) Pandemic In The United States, Sera Yoo, William Eger, Ashley Moore, Emily Miron, Marney A. White

Cooper Rowan Medical Journal

Introduction: There have been over 87 million cases of Coronavirus Disease 2019 (COVID-19) in the United States (US).

Objective: The objective of this study was to develop a novel questionnaire to assess risk perception of COVID-19 and xenophobic attitudes among adults in the US at the beginning of the pandemic.

Methods: An anonymous self-report questionnaire was developed for this study in February 2020, and was distributed using convenience sampling from March 10 to March 25, 2020. The questionnaire assessed knowledge and risk perceptions of COVID-19, as well as attitudes toward individuals of various races and ethnicities.

Results: 662 US adults …

Coping With Covid Through Tangled And Social Media, Maram Alturky

Criterion: A Journal of Literary Criticism

In response to the events of COVID-19 in 2020, social content creators found connections between their lives and the life of Rapunzel as represented in Disney’s 2010 retelling of the Rapunzel tale, Tangled. To show these connections, YouTube videos were made to highlight the similarities between people’s lives under quarantine and Rapunzel’s containment in the tower. While these videos were seemingly made to play on current life events, they illustrate the many ways in which fairy tales have been used to bridge the fantastical and reality when attempting to cope with trauma. This article explores the connections between fairy tales …

Rapid Direct Detection Of Sars-Cov-2 Aerosols In Exhaled Breath At The Point Of Care, Dishit P Ghumra, Nishit Shetty, Kevin R Mcbrearty, Joseph V Puthussery, Benjamin J Sumlin, Woodrow D Gardiner, Brookelyn M Doherty, Jordan P Magrecki, Jane A O'Halloran, Rachel M Presti, Traci L Bricker, Adrianus C M Boon, Carla M Yuede, John R Cirrito, Rajan K Chakrabarty, Et Al.

2020-Current year OA Pubs

Airborne transmission via virus-laden aerosols is a dominant route for the transmission of respiratory diseases, including severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Direct, non-invasive screening of respiratory virus aerosols in patients has been a long-standing technical challenge. Here, we introduce a point-of-care testing platform that directly detects SARS-CoV-2 aerosols in as little as two exhaled breaths of patients and provides results in under 60 s. It integrates a hand-held breath aerosol collector and a llama-derived, SARS-CoV-2 spike-protein specific nanobody bound to an ultrasensitive micro-immunoelectrode biosensor, which detects the oxidation of tyrosine amino acids present in SARS-CoV-2 viral particles. Laboratory …

When Kinship Caregivers Became Teachers: Role Stress And Strain From Remote Learning During Covid-19, Amanda Klein-Cox, Angela Tobin, Ramona Denby

Social Work Faculty Research

For caregivers of school-age children, schooling at home was a significant stressor during the COVID-19 pandemic. Research demonstrates the emotional burden of taking on the role of teacher while trying to balance responsibilities related to work, household, and childcare. Yet little is known about the well-being of kinship caregivers during this time, although this population is at heightened risk for role stress and strain and emotional distress. This article shares the results of focus groups conducted as part of a larger qualitative study, the purpose of which was to understand the factors that influenced the well-being of kinship families during …

The Impact Of Covid-19 On Leadership Development And Burnout Among Korean Immigrant Church Leaders In The United States: A Phenomenological Study, Jinwon Seo

Doctoral Dissertations and Projects

The global outbreak and pandemic of COVID-19 is an unprecedented event that causes many people to experience psychological, spiritual, and social health crises as well as physical crisis. There is limited empirical research existed on the influence of COVID-19 on church leaders, particularly within the Korean immigrant community. A phenomenological approach was adopted, utilizing semi-structured individual interviews with Korean immigrant church leaders to explore their lived experiences during the pandemic. The findings revealed three primary themes: change, support, and burnout. Korean immigrant church leaders demonstrated balanced leadership development in guiding, providing, and protecting roles, but also experienced exhaustion due to …

The Experiences Of Tier 3 Early Reading Intervention Providers Three Years After A School Closure: A Phenomenological Study, Sue Ellen Nilena Washington

Doctoral Dissertations and Projects

The purpose of this transcendental phenomenological study was to describe the lived experiences of Tier 3 early reading intervention providers at the Urban Independent School District in Texas three years after a school closure. The central research question was, what are the lived experiences of Tier 3 early reading intervention providers in the Urban Independent School district three years after a school closure? Sub-questions explored early reading intervention providers’ beliefs, attitudes, mental states, and actions three years after a school closure. This study was guided by two central theories: the Vygotskian sociocultural theory of human learning and Bandura’s self-efficacy theory. …

A Case Study On How Hbcus Use Social Media To Reduce Uncertainty Of Covid-19, Kelsey Anne-Gabrielle Armstrong

Doctoral Dissertations and Projects

This case study aims to understand how HBCUs use social media to deliver crisis communication messages to students about COVID-19 and how the HBCU culture impacts student perspectives. The theory guiding this study is uncertainty reduction theory (Berger & Calabrese, 1974), as it explains the communication strategies used to reduce uncertainty during a crisis. Data collection was conducted using semi-structured interviews and content analysis. Data analysis strategies included deductive and inductive coding and directed content analysis. The study results provide insight into how the HBCU culture impacts the perspective of an HBCUs response to COVID-19 and overall crisis communication messaging …

Remote Learning In Collegiate Instrumental Courses: The Impact Of Remote Learning During The Covid-19 Pandemic And The Future Of Remote Learning, Beverly R. Gard

Doctoral Dissertations and Projects

During the 2020-2022 COVID-19 pandemic, many colleges were required to transition to a remote learning platform. This was a new concept to many professors and proved to impact college courses, including courses that relied on in-person learning and interactions, such as instrumental music courses. Courses were affected because teaching and learning methods that applied to in-person learning were not entirely possible with remote learning due to the mandates of social distancing and the lack of face-to-face instruction. Many music professors were required to make necessary changes to the curriculum, teaching styles, and educational technologies. Courses required new and innovative ways …

Rebuilding The Secondary School Choral Program After The Covid-19 Pandemic: Tools For Teachers And Administrators And Implications For Future Disruptions To Education, Brandon Allan Stroup

Doctoral Dissertations and Projects

Due to the COVID-19 pandemic, many secondary choral music programs suffered in terms of student involvement, performances, the ability to rehearse, and the overall impact on students’ social and emotional health. Choral music educators have been tasked with implementing strategies to rebuild their programs as schools resumed in-person learning. Utilizing explanatory sequential mixed methods, this study considered surveys of choral music educators and disaggregated student perception data, analyzing the specific needs of students, as well as utilized research surrounding the influence of the COVID-19 pandemic on the social and emotional health of students. Guided by student perception surveys, this mixed …

Covid-19 Mortality Rates Were Higher In States That Limited Governments From Enacting Public Health Emergency Orders, Xue Zhang, Mildred E. Warner, Gen Meredith

Population Health Research Brief Series

State and local governments enacted various public health emergency policies during the COVID-19 pandemic, resulting in lower infection and death rates than would have occurred without these policies. However, some states limited the emergency public health authority of state executives, state governors, and other state and local officials during the pandemic. This brief summarizes the results of a study that used data from the Center for Public Health Law Research and Oxford COVID-19 Government Response Tracker to explore which states passed laws that limited emergency public health authority during the COVID-19 pandemic and the effects of those limits on COVID-19 …

Isolated & Impulsive: A Quality Improvement Pilot Survey Of The Perceived Icu Nurse Workload Implementing The A2f Care Bundle For Isolated Covid-19 Patients With Delirium., Ranier Calimlim

College of Science and Health Theses and Dissertations

Background: Existing research focused on A2F Care Bundle efficacy to optimize patient care and improve patient outcomes among ICU patients. Perceived workflow evaluation has been validated for healthcare task analysis endorsed by the Agency for Healthcare Research and Quality. A needs assessment was identified to evaluate nursing challenges with the A2F Care Bundle interventions, inform allocation where support and resources may be necessary when providing patient care for isolated patients with COVID-19 delirium.

Purpose: The purpose of this study was to evaluate the perceived workload of ICU nurses when implementing the A2F Care Bundle among isolated COVID-19 patients with delirium. …

Emotional Distress During Covid-19 By Mental Health Conditions And Economic Vulnerability: Retrospective Analysis Of Survey-Linked Twitter Data With A Semisupervised Machine Learning Algorithm, Michiko Ueda-Ballmer, Kohei Watanabe, Hajime Sueki

Center for Policy Design and Governance

The brief summarizes "Emotional Distress During COVID-19 by Mental Health Conditions and Economic Vulnerability: Retrospective Analysis of Survey-Linked Twitter Data With a Semisupervised Machine Learning Algorithm," co-authored by Michiko Ueda-Ballmer, Kohei Watanabe, and Hajime Sueki in the Journal of Medical Internet Research.

Evaluation Of Local And Systemic Side Effects Of Turkovac Vaccine In Adults, Bülent Nuri̇ Kalayci, Doğu Karahan

Turkish Journal of Medical Sciences

Background/aim: COVID-19 is a respiratory disease that caused a pandemic after reportedly emerging from Wuhan, China, in December 2019. Different types of COVID-19 vaccines such as viral vectors, mRNA, and inactivated vaccines have been produced since the beginning of the pandemic. Turkovac is an inactive COVID-19 vaccine developed and produced in Türkiye. We conducted our study to investigate the local and systemic side effects of the Turkovac vaccine. Materials and methods: A cross-sectional survey-based study was conducted to collect data on the postvaccine side effects in people aged over 18 who were vaccinated with Turkovac, between March and June 2022, …

Impact Of Covid-19 On Service Dog Organizations, Danny Benbassat, Abigail Konopasky, Michael Fox

People and Animals: The International Journal of Research and Practice

The 2019 coronavirus pandemic led to federal, state, and local measures that paralyzed businesses across the nation. Among them were behavioral and mental health nonprofit organizations. The purpose of this study was to understand the impact of the pandemic on nonprofit programs that train and place service dogs with veterans/service members. Six service dog managers completed eight reflection probe questionnaires and participated in three focus groups. This study found that facility shutdown, businesses shutdown, and social distancing resulted in a training bottleneck for both canines and humans. These primary challenges created secondary and tertiary challenges that mirror and lend support …

How Did Latinxs Near The U.S.-Mexico Border Fare During The Covid-19 Pandemic? A Snapshot Of Anxiety, Depression, And Posttraumatic Stress Symptoms, Bianca T. Villalobos, Juventino Hernandez Rodriguez

Psychological Science Faculty Publications

Introduction: The current study documented levels of anxiety, depression, posttraumatic stress, and COVID-19 fears and impacts among Latinxs living near the U.S.-Mexico border during the COVID-19 pandemic.

Methods: Participants of this cross-sectional study were 305 Latinx adults living in the Rio Grande Valley (RGV) who completed an online survey between June and November 2020.

Results: About half of participants scored above the cut-off for anxiety (50.2%; GAD-7 scores ≥10) and depression (48.8%; PHQ-9 scores ≥10), and more than a quarter of participants showed clinical levels of posttraumatic stress (27.3%; PCL-5 scores ≥31). Latinxs reported on average 22 types of negative …

Perspectives On The Doctor Of Public Health (Drph) Education Among Students And Alumni In The United States: A Cross-Sectional National Online Survey., Chulwoo Park, Cindy Delgado, Ans Irfan

Health Sciences Education Research

BACKGROUND: This study explored the current and desired identity of the DrPH degree, focusing on whether the competencies set by the Council on Education for Public Health (CEPH) adequately prepare DrPH graduates for effective public health practice. Additionally, the study investigated the necessity of standardization in DrPH training, referring to a consensus-driven approach that equips future public health practitioners with practical skillsets applicable in real-world scenarios.

METHODS: A national cross-sectional online survey titled "National DrPH leaders & practitioners needs assessment" was conducted from November 2020 to February 2021. The survey was based on a self-report by DrPH students and DrPH …

Covid-19 Mortality Rates Were Higher In States That Limited Governments From Enacting Public Health Emergency Orders, Xue Zhang, Mildred Warner, Gen Meredith

Center for Policy Research

State and local governments enacted various public health emergency policies during the COVID-19 pandemic that resulted in lower infection and death rates than would have occurred without these policies. However, some states limited emergency public health authority of state executives, state governors, and state and local officials during the pandemic. This brief summarizes the results of a study that used data from the Center for Public Health Law Research and Oxford COVID-19 Government Response Tracker to explore which states passed laws that limited emergency public health authority during the COVID-19 pandemic and the effects of those limitations on COVID-19 death …

Automated Lung Ultrasound Pulmonary Disease Quantification Using An Unsupervised Machine Learning Technique For Covid-19, Hersh Sagreiya, Michael A Jacobs, Alireza Akhbardeh

Faculty, Staff and Student Publications

COVID-19 is an ongoing global health pandemic. Although COVID-19 can be diagnosed with various tests such as PCR, these tests do not establish pulmonary disease burden. Whereas point-of-care lung ultrasound (POCUS) can directly assess the severity of characteristic pulmonary findings of COVID-19, the advantage of using US is that it is inexpensive, portable, and widely available for use in many clinical settings. For automated assessment of pulmonary findings, we have developed an unsupervised learning technique termed the calculated lung ultrasound (CLU) index. The CLU can quantify various types of lung findings, such as A or B lines, consolidations, and pleural …

The Impact Of Covid-19 On Collaboration Between School Psychologists And Board-Certified Behavioral Analysts, Taylor Bronaugh

Department of Graduate Psychology - Masters Theses

The aim of this paper is to examine the impact of communication styles brought on by distanced learning and its effect on collaboration for school psychologists and Bord Certified Behavioral Analysts (BCBAs). Prior studies have addressed collaboration habits between these school-based professionals. The current study aims to analyze the impact that COVID-19 had on these practitioners’ collaboration habits and to investigate their current communication and collaboration habits. A mixed methods locally developed anonymous survey was created and used for data collection. Participants were recruited through social-media groups and via word-of-mouth sharing. 20 school-based practitioners shared their perceptions and experiences with …

The Impact Of Covid-19 On Collaboration Between School Psychologists And Board-Certified Behavioral Analysts, Taylor J. Bronaugh

Educational Specialist, 2020-current

The aim of this paper is to examine the impact of communication styles brought on by distanced learning and its effect on collaboration for school psychologists and Bord Certified Behavioral Analysts (BCBAs). Prior studies have addressed collaboration habits between these school-based professionals. The current study aims to analyze the impact that COVID-19 had on these practitioners’ collaboration habits and to investigate their current communication and collaboration habits. A mixed methods locally developed anonymous survey was created and used for data collection. Participants were recruited through social-media groups and via word-of-mouth sharing. 20 school-based practitioners shared their perceptions and experiences with …

Examining Drinking To Cope During The Covid-19 Pandemic As Reinforcement Pathology, Matthew Dwyer

Theses and Dissertations

The COVID-19 pandemic is the largest global public health challenge of this century. Concerns were raised that the rapid changes associated with daily life during the initial months of the pandemic would increase depression and alcohol use. However, changes in population-level alcohol use have been mixed. Behavioral economic theories of addiction, such as the Reinforcer Pathology (RP) model, have been proposed as well suited to identify individuals, and inform interventions, to address these concerns. However, no quantitative research has validated this claim in a sample recruited during the pandemic. The current study extended upon existing research by examining patterns of …

Delayed Discovery: The Covid-19 Pandemic’S Influence On Osteoarthritis Clinical Trials, Nicholas B. Sajjadi, J. Michael Anderson, Griffin K. Hughes, Christena Abraham, Jamal Malik, Micah Hartwell, Matt Vassar

Student Publications

Context: The COVID-19 pandemic disrupted clinical research in many medical and surgical fields, resulting in research waste and loss of treatment for patients. Although other areas have been explored, the extent of the pandemic’s influence on osteoarthritis (OA) trials is currently unknown.

Objectives: This study aims to explore the reasons for termination of clinical trials investigating OA during the COVID-19 pandemic.

Methods: We searched ClinicalTrials.gov for OA trials and characterized their reason for discontinuation, noting where trialists directly cited the COVID-19 pandemic as the reason for trial discontinuation. We also coded other common reasons for trial discontinuation. Descriptive and inferential …

Non-Histaminergic Angioedema Following Infection With Covid-19, Sheza Malik, Basil George Verghese, S Shahzad Mustafa

Advances in Clinical Medical Research and Healthcare Delivery

Non-respiratory manifestations of COVID-19, including dermatological manifestations, have been reported, and although urticaria associated with COVID-19 has been reported, there have been no reports of non-histaminergic angioedema following infection with mild COVID-19. Non-histaminergic angioedema has a gradual onset and is characterized by submucosal swelling without accompanying urticaria or pruritus, and poor response to antihistamines and corticosteroids. We report a case of non-histaminergic angioedema in a 29-year-old woman with a history of mild COVID-19 infection. Our case highlights the fact that early diagnosis of non-histaminergic angioedema in mild COVID-19 patients is crucial for effective treatment and requires a high level of …

Archival Research In The Time Of Coronavirus, Kelly K. Hudson, Heather Gilbert

South Carolina Libraries

Two Special Collections directors explore the challenges and strategies of delivering archival services during a global pandemic at their respective academic repositories: Special Collections at the College of Charleston and the Harry Ransom Center at the University of Texas.

Promotion Strategies In Academic Libraries: Improving The Ability Of Students To Access Information Resources And Services During The Covid-19 Era, Tinyiko Vivian Dube

Library Philosophy and Practice (e-journal)

This article identified the library promotion strategies that distance education academic library services can employ to improve the ability of remote clients to access information resources during the COVID-19 pandemic. Academic libraries operating in a distance education environment in Gauteng Province, South Africa, are currently changing how library and information services are provided to remote clients. The traditional means of promoting library services through posters, banners, flyers, and pamphlets are now in the past. The emergence of COVID-19 facilitated information technologies. The study was anchored by the positivism research paradigm and used a quantitative approach. Microsoft Form was used to …

Time To Transform: Challenges And Opportunities For Teaching Practice During Covid-19 And Beyond, Muhammad Abid Malik Mam, Hina Amin Ha, Saleha Ali Sa

The Qualitative Report

Teaching practice is one of the most significant components of a teacher education program that prepares prospective teachers for a fast-changing and technology-infused world. However, in many developing countries like Pakistan, it has remained stuck in the traditional methods (face-to-face, without proper utilization of technology) which made it vulnerable during COVID-19. This study explores teaching practice methods and strategies used by Pakistani universities before and during COVID-19. It further identifies the causes behind its deficiencies to prepare prospective teachers for the challenges of the current era. Using semi-structured interviews, data was gathered from nine teaching practice supervisors from nine different …

Prevalence Of Symptoms ≤12 Months After Acute Illness, By Covid-19 Testing Status Among Adults — United States, December 2020–March 2023, Juan Carlos C Montoy, James Ford, Huihui Yu, Michael Gottlieb, Dana Morse, Michelle Santangelo, Kelli N O'Laughlin, Kevin Schaeffer, Pamela Logan, Kristin Rising, Mandy J Hill, Lauren E Wisk, Wafah Salah, Ahamed H Idris, Ryan M Huebinger, Erica S Spatz, Robert M Rodriguez, Robin E Klabbers, Kristyn Gatling, Ralph C Wang, Joann G Elmore, Samuel A Mcdonald, Kari A Stephens, Robert A Weinstein, Arjun K Venkatesh, Sharon Saydah, Innovative Support For Patients With Sars-Cov-2 Infections Registry (Inspire) Group

Faculty, Staff and Student Publications

To further the understanding of post-COVID conditions, and provide a more nuanced description of symptom progression, resolution, emergence, and reemergence after SARS-CoV-2 infection or COVID-like illness, analysts examined data from the Innovative Support for Patients with SARS-CoV-2 Infections Registry (INSPIRE), a prospective multicenter cohort study. This report includes analysis of data on self-reported symptoms collected from 1,296 adults with COVID-like illness who were tested for SARS-CoV-2 using a Food and Drug Administration-approved polymerase chain reaction or antigen test at the time of enrollment and reported symptoms at 3-month intervals for 12 months. Prevalence of any symptom decreased substantially between baseline …