Digital Commons Network^™

Coagulopathy In Severe Covid-19 Patients: Causes, Concerns And Current Treatment Regimen, Tanusree Sengupta, Arun Luiz, Chennakesavan Suganthi, Samarpan Majumder

School of Graduate Studies Faculty Publications

Elevated D-dimer and fibrinogen level, mild thrombocytopenia, modest prolongation of prothrombin time, and activated partial thromboplastin time, are key indicators of coagulopathy, and have been consistently reported in severely ill COVID-19 patients. Coronavirus disease 2019 (COVID-19)-induced coagulopathy can develop serious venous and arterial thromboembolic complications. Endothelial dysfunction and hypercoagulability, triggered mostly by overproduction of inflammatory cytokines as an immune response to the infection, are the pivotal factors responsible for the above-mentioned coagulation disorder. Thus, low-molecular-weight heparin (LMWH), which has both anticoagulant and anti-inflammatory properties, has been reported to improve disease prognosis. However, there have been increasing reports of venous thromboembolic …

Moral Mobilization In The Digital Space: Seafarers Exercising Agency During The Pandemic, Lijun Tang

Plymouth Business School

The agency of casualized and spatially isolated workers has recently received increased research attention. This paper extends this line of research to seafarers, a traditional but also casualized and spatially isolated workforce. More specifically, it examines cases of collective action by Chinese seafarers on WeChat, a social media platform, in response to problems and grievances caused by COVID-19 control measures during the pandemic. It shows that seafarers, building on the WeChat platform and together with other maritime stakeholders, have established a socio-technological infrastructure that enables them to mobilize their peers to take action when they experience injustice at work. Their …

Covid-19 Convalescent Plasma Therapy Decreases Inflammatory Cytokines: A Randomized Controlled Trial, Feben Habtehyimer, Xianming Zhu, Andrew D Redd, Kelly A Gebo, Alison G Abraham, Eshan U Patel, Oliver Laeyendecker, Thomas J Gniadek, Reinaldo E Fernandez, Owen R Baker, Malathi Ram, Edward R Cachay, Judith S Currier, Yuriko Fukuta, Jonathan M Gerber, Sonya L Heath, Barry Meisenberg, Moises A Huaman, Adam C Levine, Aarthi Shenoy, Shweta Anjan, Janis E Blair, Daniel Cruser, Donald N Forthal, Laura L Hammitt, Seble Kassaye, Giselle S Mosnaim, Bela Patel, James H Paxton, Jay S Raval, Catherine G Sutcliffe, Matthew Abinante, Kevin S Oei, Valerie Cluzet, Marie Elena Cordisco, Benjamin Greenblatt, William Rausch, David Shade, Amy L Gawad, Sabra L Klein, Andrew Pekosz, Shmuel Shoham, Arturo Casadevall, Evan M Bloch, Daniel Hanley, Aaron A R Tobian, David J Sullivan

Faculty, Staff and Student Publications

This study examined the role that cytokines may have played in the beneficial outcomes found when outpatient individuals infected with SARS-CoV-2 were transfused with COVID-19 convalescent plasma (CCP) early in their infection. We found that the pro-inflammatory cytokine IL-6 decreased significantly faster in patients treated early with CCP. Participants with COVID-19 treated with CCP later in the infection did not have the same effect. This decrease in IL-6 levels after early CCP treatment suggests a possible role of inflammation in COVID-19 progression. The evidence of IL-6 involvement brings insight into the possible mechanisms involved in CCP treatment mitigating SARS-CoV-2 severity.

Waiving Snap Interviews During The Covid-19 Pandemic Increased Snap Caseloads, Colleen Heflin, William Clay Fannin, Leonard M. Lopoo, Siobhan O'Keefe

Center for Policy Research

Food insecurity in the United States reached historically high rates during the COVID-19 pandemic, thus substantially increasing demand for the Supplemental Nutrition Assistance Program (SNAP). To facilitate access to SNAP during the pandemic, the federal government granted state SNAP offices the option to waive the interview requirement – an administrative burden associated with the SNAP certification process. This brief summarizes findings from a recent study that used data from SNAP offices across 10 states to examine the impact of SNAP interview waivers on SNAP caseloads from January 5th to April 30th of 2021. Findings reveal that counties that implemented the …

Cost-Effectiveness Analysis Of Favipiravir And Remdesivir As Covid-19 Treatment In South Tangerang, Banten Province - Indonesia, Wahyu G. Putro, Andriani R. Fahriyati, Gilberto A. Julian, Tania R. Amalia, Zaki M. Riski

Pharmacology and Clinical Pharmacy Research

COVID-19 is a contagious ailment primarily attributed to the severe acute respiratory syndrome coronavirus. Indonesia persists in confronting the COVID-19 pandemic, and South Tangerang City has emerged as one of the municipalities in Indonesia that has been significantly affected. There are two categories of medications employed for COVID-19 treatment according to government policies, namely favipiravir and remdesivir. This study aims to as- sess the cost-effectiveness of favipiravir and remdesivir medications at the South Tangerang General Hospital, Indonesia. The present study employs a retrospective research design characterized by a quantitative approach, utilizing cross-sectional methodologies. The analy- sis mostly consists of descriptive …

The Unprecedented Stressors Of Early Childhood Educators During The Covid-19 Pandemic And Post-Pandemic Restoration: A Case Study, Ida Mae Lewis

Doctoral Dissertations and Projects

The purpose of this case study was to describe the unprecedented stressors of early childhood educators (ECE) during the COVID-19 pandemic and the post-pandemic restoration at two early childhood education centers (ECEC) in a midwestern state. The central research question was: How did the COVID-19 pandemic’s unprecedented stressors impact ECE in the post-pandemic era? Data collection included structured interviews with open-ended questions, focus groups, and documents. The three data sources were triangulated for themes, perspectives, and interpretations, and coding was used to help gain a deep understanding of the stressors experienced by early childhood educators. The conceptual framework guiding this …

Assessing Covid-Related Concerns And Their Impact On Antenatal And Delivery Care Among Pregnant Women Living With Hiv In Kenya: A Brief Report., Catherine Wexler, May Maloba, Sharon Mokua, Shadrack Babu, Nicodemus Maosa, Vincent Staggs, Kathy Goggin, Harshdeep Acharya, Emily A. Hurley, Sarah Finocchario-Kessler

Manuscripts, Articles, Book Chapters and Other Papers

BACKGROUND: Some studies indicate that pregnant Kenyan women were concerned about Coronavirus disease 2019 (COVID-19) exposure during maternity care. We assessed concern regarding COVID-19 exposure and any impact on antenatal care (ANC) enrollment and/or hospital delivery among pregnant women living with human immunodeficiency virus (HIV) in Kenya.

METHODS: Data were collected from 1,478 pregnant women living with HIV enrolled in prevention of mother to child transmission of HIV (PMTCT) care at 12 Kenyan hospitals from October 2020 to July 2022. Surveys were conducted when women first presented for PMTCT services at the study hospital and asked demographic questions as well …

Impact Of The Increased Use Of Telehealth On Health Care Management And Administration: The Case Of New Care Management Practices, Immacula Pierre

Doctoral Dissertations and Projects

The COVID-19 pandemic has brought unprecedented challenges to healthcare systems worldwide, forcing them to adapt and implement alternative modes of healthcare delivery quickly. Telehealth, the delivery of healthcare services through telecommunication technologies, has become crucial in providing continuous care while reducing the risk of virus transmission. This qualitative study aimed to explore healthcare managers' perceptions of the use of telehealth and its impact on healthcare practices during the pandemic, particularly in terms of provision and quality control. A purposive sample of 10 healthcare managers from different healthcare settings in the United States participated in semi-structured interviews conducted via video conferencing. …

Systemic Racism And Covid-19: Vulnerabilities With The U.S. Social Safety Net For Immigrants And People Of Color, Adam M. Butz, Jason E. Kehrberg

Journal of Public Management & Social Policy

America has a mythologized reputation as an accommodative “melting pot” nation that welcomes individuals from all races and countries seeking improved quality of life and reduced material hardship. However, our U.S. social welfare system is more broadly characterized as underdeveloped, restrictive, and exclusionary, especially toward immigrants and people of color. Public health benefits (e.g., Medicaid), food assistance programs (e.g., SNAP), rental assistance (e.g., HCV/Section 8), and cash assistance (e.g., TANF) are oftentimes restricted for immigrants and racial minorities, making them more vulnerable to material hardship and more exposed to pandemic conditions under COVID-19. Moreover, these welfare restrictions are oftentimes rooted …

Fitting A Covid-19 Model Incorporating Senses Of Safety And Caution To Local Data From Spartanburg County, South Carolina, D. Chloe Griffin, Amanda Mangum

CODEE Journal

Common mechanistic models include Susceptible-Infected-Removed (SIR) and Susceptible-Exposed-Infected-Removed (SEIR) models. These models in their basic forms have generally failed to capture the nature of the COVID-19 pandemic's multiple waves and do not take into account public policies such as social distancing, mask mandates, and the ``Stay-at-Home'' orders implemented in early 2020. While the Susceptible-Vaccinated-Infected-Recovered-Deceased (SVIRD) model only adds two more compartments to the SIR model, the inclusion of time-dependent parameters allows for the model to better capture the first two waves of the COVID-19 pandemic when surveillance testing was common practice for a large portion of the population. We find …

Effect Of Anti-Interleukin-6 Agents On Psychopathology In A Sample Of Patients With Post-Covid-19 Syndrome: An Observational Study, Alessio Simonetti, Antonio Restaino, Evelina Bernardi, Ottavia Marianna Ferrara, Stella Margoni, Antonio Maria D'Onofrio, Federica Ranieri, Delfina Janiri, Vincenzo Galluzzo, Matteo Tosato, Georgios D Kotzalidis, Francesco Landi, Gabriele Sani

Faculty, Staff and Students Publications

Interleukin 6 (IL-6) receptor inhibitors tocilizumab and sarilumab have recently been approved for severe coronavirus disease 2019 (COVID-19). They also affect mood, even though their effect on the post-COVID-19 syndrome-related psychopathology still has to be investigated. The aim of this study was to investigate their effect on psychopathology in a sample of patients with post-COVID-19 syndrome. We included 246 patients (34% female, 66% male) aged 18–75 years who had been hospitalized for COVID. Patients were split into those who received anti-IL-6 receptor agents (Anti-IL-6-R, N = 88) and those who did not (Ctrl, N = 158). The former group was …

Features Of Acute Covid-19 Associated With Post-Acute Sequelae Of Sars-Cov-2 Phenotypes: Results From The Impacc Study, Al Ozonoff, Naresh Doni Jayavelu, Shanshan Liu, Esther Melamed, Carly E Milliren, Jingjing Qi, Linda N Geng, Grace A Mccomsey, Charles B Cairns, Lindsey R Baden, Joanna Schaenman, Albert C Shaw, Hady Samaha, Vicki Seyfert-Margolis, Florian Krammer, Lindsey B Rosen, Hanno Steen, Caitlin Syphurs, Ravi Dandekar, Casey P Shannon, Rafick P Sekaly, Lauren I R Ehrlich, David B Corry, Farrah Kheradmand, Mark A Atkinson, Scott C Brakenridge, Nelson I Agudelo Higuita, Jordan P Metcalf, Catherine L Hough, William B Messer, Bali Pulendran, Kari C Nadeau, Mark M Davis, Ana Fernandez Sesma, Viviana Simon, Harm Van Bakel, Seunghee Kim-Schulze, David A Hafler, Ofer Levy, Monica Kraft, Chris Bime, Elias K Haddad, Carolyn S Calfee, David J Erle, Charles R Langelier, Walter Eckalbar, Steven E Bosinger, Bjoern Peters, Steven H Kleinstein, Elaine F Reed, Alison D Augustine, Joann Diray-Arce, Holden T Maecker, Matthew C Altman, Ruth R Montgomery, Patrice M Becker, Nadine Rouphael

Faculty, Staff and Students Publications

Post-acute sequelae of SARS-CoV-2 (PASC) is a significant public health concern. We describe Patient Reported Outcomes (PROs) on 590 participants prospectively assessed from hospital admission for COVID-19 through one year after discharge. Modeling identified 4 PRO clusters based on reported deficits (minimal, physical, mental/cognitive, and multidomain), supporting heterogenous clinical presentations in PASC, with sub-phenotypes associated with female sex and distinctive comorbidities. During the acute phase of disease, a higher respiratory SARS-CoV-2 viral burden and lower Receptor Binding Domain and Spike antibody titers were associated with both the physical predominant and the multidomain deficit clusters. A lower frequency of circulating B …

Inpatient Costs Of Treating Patients With Covid-19, Kandice A Kapinos, Richard M Peters, Robert E Murphy, Samuel F Hohmann, Ankita Podichetty, Raymond S Greenberg

Faculty, Staff and Student Publications

IMPORTANCE: With more than 6.2 million hospitalizations due to COVID-19 in the US, recognition of the average hospital costs to provide inpatient care during the pandemic is necessary to understanding the national medical resource use and improving public health readiness and related policies.

OBJECTIVE: To examine the mean cost to provide inpatient care to treat COVID-19 and how it varied through the pandemic waves and by important sociodemographic patient characteristics.

DESIGN, SETTING, AND PARTICIPANTS: This cross-sectional study used inpatient-level data from March 1, 2020, to March 31, 2022, extracted from a repository of clinical, administrative, and financial information covering 97% …

Collateral Effects Of Covid-19 Stay-At-Home Orders On Violence Against Women In The United States, January 2019 To December 2020, Patricia C. Lewis, Yuk F. Cheong, Nadine J. Kaslow, Kathryn M. Yount

Health Science Faculty Publications

Background: The necessary execution of non-pharmaceutical risk-mitigation (NPRM) strategies to reduce the transmission of COVID-19 has created an unprecedented natural experiment to ascertain whether pandemic-induced social-policy interventions may elevate collateral health risks. Here, we assess the efects on violence against women (VAW) of the duration of NPRM measures that were executed through jurisdictional-level orders in the United States. We expect that stay-at-home orders, by reducing mobility and disrupting non-coresident social ties, are associated with higher incident reporting of VAW.

Methods: We used aggregate data from the Murder Accountability Project from January 2019 through December 2020, to estimate count models examining …

Integrated Multi-Omics Analyses Identify Anti-Viral Host Factors And Pathways Controlling Sars-Cov-2 Infection, Jiakai Hou, Yanjun Wei, Jing Zou, Roshni Jaffery, Long Sun, Shaoheng Liang, Ningbo Zheng, Ashley M Guerrero, Nicholas A Egan, Ritu Bohat, Si Chen, Caishang Zheng, Xiaobo Mao, S Stephen Yi, Ken Chen, Daniel J Mcgrail, Nidhi Sahni, Pei-Yong Shi, Yiwen Chen, Xuping Xie, Weiyi Peng

Faculty, Staff and Student Publications

Host anti-viral factors are essential for controlling SARS-CoV-2 infection but remain largely unknown due to the biases of previous large-scale studies toward pro-viral host factors. To fill in this knowledge gap, we perform a genome-wide CRISPR dropout screen and integrate analyses of the multi-omics data of the CRISPR screen, genome-wide association studies, single-cell RNA-Seq, and host-virus proteins or protein/RNA interactome. This study uncovers many host factors that are currently underappreciated, including the components of V-ATPases, ESCRT, and N-glycosylation pathways that modulate viral entry and/or replication. The cohesin complex is also identified as an anti-viral pathway, suggesting an important role of …

Labour Force Participation And Type Of Work Older Persons In Vietnam Before And During Covid-19, Trieu Thi Phuong, Pataporn Sukontamarn

Journal of Demography

Vietnam is ageing rapidly and is predicted to enter an aged society within the next fifteen years, posing a major challenge for a lower middle-income nation with an incomplete social security system. Supporting older persons to continue working can be a reasonable strategy to ensure their life quality and reduce the burden on the national social security system. Our study aims to investigate the determinants of older persons’ participation in the labour force and their type of work. Based on the 2018 and 2020 Vietnam Housing and Living Standard surveys, health problems, pension status, and level of education significantly explain …

The Impact Of Loneliness Post-Pandemic And Immersed In The Upcoming Political Election, Regina M. Luttrell Ph.D., Gwen Pratt, Abigail Kludt, Amy Barone, Kwadwo Osei-Poku, Lihan Wang

Real Chemistry Emerging Insights Lab

The Real Chemistry Emerging Insights Lab emerged with a partnership between Real Chemistry and the Public Relations department at the S.I. Newhouse School of Public Communication and serves as a multidisciplinary research center focusing on analytics, artificial intelligence, digital and emerging media for a number of organizations regarding communications.

Healthcare professionals and organizations are interested in identifying how mental health impacts different U.S. generational groups after the COVID-19 pandemic and the intersectionality of U.S. Politics. Our team focused on two generational cohorts – Generation X (1965-1980) and Generation Z (1997-2012) – as an entry point into navigating the impact of …

Time Series Forecasting Of New Cases For Covid-19 Pandemic In Jordan Using Enhanced Hybrid Emd-Arima, Ahmad M. Awajan, Bilal Al-Hasanat, Elarbi Elkaroui, Ayed Al E’Damat, Remal S. Al-Gounmeein, Abdullah S. Al- Jawarneh

Journal of Statistics Applications & Probability

In this study, the enhanced hybrid empirical mode decomposition with autoregressive integrated moving average (EMD- ARIMA) method is proposed and applied to forecast daily new COVID-19 reported cases in Jordan. The EMD method is applied to decompose the COVID-19 data into a number of IMFs components as a simple time series. Then, the appropriate ARIMA(p,d,q) model is applied to evaluate the forecasting value for the low-frequency components. Then, the forecasting results are collected together. Data for this study are collected from the Jordanian Ministry of Health. Seven forecasting accuracy measures are employed to compare the forecasting results of the proposed …

A Qualitative Case Study Of Disabled Students’ Experiences With Online Course Accessibility During The Covid-19 Pandemic, Jason Altmann

Dissertations of Practice

ABSTRACT

A QUALITATIVE CASE STUDY OF DISABLED STUDENTS’

EXPERIENCES WITH ONLINE COURSE ACCESSIBILITY

DURING THE COVID-19 PANDEMIC

Jason Altmann, Ed.D.

Department of Counseling and Higher Education

Northern Illinois University, 2024

Xiaodan Hu, Director

This dissertation presents a qualitative case study exploring the experiences of disabled students with online course accessibility during the COVID-19 pandemic. The study investigates how the abrupt shift to online learning impacted the accessibility of educational materials and support services for disabled students in a large, suburban community college.

Critical Disability Theory (CDT) framework was utilized to guide interview questions and explore the connection between the initial …

Did The Change In Snap Ebt Benefits In Response To Covid-19 Affect Poverty, Snap Participation, And Food Insecurity Rates?, Paige Thing

2024 Awards for Excellence in Student Research and Creative Activity - Documents

The Supplemental Nutrition Assistance Program, or SNAP, is one of the most important welfare programs the United States government offers. In fiscal year 2015, one in every seven Americans received SNAP assistance. Previously called food stamps as they were first introduced with the passing of the Food and Agriculture Act in 1977, this program has been helping individuals struggling with food insecurity for decades (Ziliak 2016). Benefits are no longer dispersed with physical stamps, restricting what households can and cannot buy. Now benefits are distributed via a debit card-type system. This is where the EBT gets added to the program …

Thymidine Phosphorylase Is A Promising Target In Sars-Cov-2 Spike Protein-Enhanced Thrombosis, Renat Roytenberg

Theses, Dissertations and Capstones

Thrombosis, as an underlying mechanism in cardiovascular diseases, is the leading global cause of death in the 21st century. Infection is a risk factor for thrombosis, and the coronavirus disease 2019 (COVID-19) pandemic has led to a rise in the incidence of thrombosis, thereby increasing mortality. In comparison to previous severe coronavirus outbreaks, rates of thrombosis in COVID-19 have been unprecedented. COVID-19 is caused by the novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The SARS-CoV-2 spike protein (SP), the key used to enter host cells, is implicated in thrombosis pathology, though mechanisms are not fully understood. The SARS-CoV-2 …

Coping With The Covid-19 Pandemic: Examining Meaning-Making In A Socioecological Framework, Emilia Eva Mikrut

Theses and Dissertations

During 2020, the COVID-19 pandemic emerged as a threatening, unpredictable, and uncontrollable stressor. Meaning-making, or one’s ability to make sense of a stressful life event, integrate the event into one’s narrative of the world and meaning in life, and accordingly revise life goals, is a salient intrapsychic process contributing to psychological adjustment in the face of very stressful or traumatic experiences such as chronic health issues, interpersonal grief, and natural and man-made disasters. Early findings provide evidence for the critical role of meaning-making in coping with stressors associated with the COVID-19 pandemic. Though meaning-making is a universal process, one’s capacity …

The Effect Of Reading Fluency After Coronavirus-19 Lockdown, Lauren Balogh

Student Research Poster Presentations 2024

This poster's research discusses the impact of the Coronavirus-19 lockdown on students' reading fluency and the effectiveness of the hybrid method. It also explores the struggles students face in meeting benchmark scores after the lockdown.

Grade Iv Glioma Potentially Disguised As Covid-19 Encephalitis, Austin Patrick Eisenberg, Nicolina Scibelli, Hannah Fischer, Victor Collier

South Atlantic Division GME Research Day 2024

No abstract provided.

Understanding The Importance Of Administrative Mental Health Support For Frontline Nurses Post Covid-19, Sarah Mah

Nursing | Senior Theses

During the peak of the COVID-19 pandemic, intensive care units and critical care units were overwhelmed with the number of patients that were on the floors. It was during this time that nurses were experiencing the most mental health decline.

Several factors can be associated with the rapid decline of nurses’ mental health. However, these issues could ultimately stem from the lack of action taken by healthcare administration. This includes increased workload and the lack of PPE, resources institutional support. Because these units played such a vital role during the pandemic, it is imperative that healthcare administrators do what they …

The Impact Of Censorship On Covid-19 Policy Formation In The United States, Victor Wallis

Faculty Works

No abstract provided.

Pandemic Pathways: An Integrated Approach To Studying The Pandemic’S Employment Impacts On Paid And Unpaid Care Of Children 0 To 11 Years Old, Johanna S. Quinn

Sociology Faculty Publications

The pandemic adversely affected the employment of child caregivers, exacerbating already existing inequalities. The authors offer an integrated framework that considers the interdependencies between unpaid and paid child caregiving and the construction of the childcare sector as a devalued and fractionalized group. The authors outline the prepandemic positioning of mothers, childcare teachers, preschool teachers, and primary school teachers. Then, using cross-sectional and panel data from the Current Population Survey, the authors describe how the pandemic affected these four groups of child caregivers’ employment between January 2018 and December 2022. Black, Brown, and non-college-educated mothers were hit particularly hard during the …

Biophilic Design And Biophilic Cities: An Explainer, Kincaid Brown

Law Librarian Scholarship

The COVID-19 pandemic brought into focus that outdoor activities in natural settings have a positive impact on mental health, and individuals participating in outdoor activity report higher rates of emotional well-being than individuals who do not participate in such activity. Biophilic design is an architectural practice that aims to connect people to nature through design concepts with one of the benefits being psychological. Other benefits of biophilic design include improvements to environmental quality, physical health, support of animal species and habitats, and more resilient and energy-efficient cities.

Between Wages And Wellbeing: Examining The Role Of Employers In Increasing Covid-19 Vaccine Uptake In The State Of West Virginia, Nathaniel Udoh Godwin

Graduate Theses, Dissertations, and Problem Reports (ETD)

The novel coronavirus disease 2019 (COVID-19) stretched public health systems globally, with millions of cases confirmed across all continents of the world. The United States health systems struggled as the country grappled with emerging variants of the virus, differing levels of vaccine acceptance, misinformation, and disparity in health outcomes. As COVID-19 vaccines emerged, the U.S. Government sought to bolster uptake through myriad measures, including announcing vaccine requirements for federal employees, which was met with mixed reactions. Accordingly, some employers and businesses adopted a “no jab, no job” policy, while others stopped short of mandates but encouraged and incentivized vaccine uptake …

Connecting In Crisis: Exploring Online Informal Communications In Florida’S Unemployment Struggle, Anna V. Eskamani

Graduate Thesis and Dissertation 2023-2024

The COVID-19 pandemic led to widespread unemployment, significantly impacting Floridians who faced delays and systemic issues with the state's unemployment system. This study examines crisis communication within a Reddit community, focusing on how individuals used informal communications to navigate the unemployment benefits crisis. Guided by Rhetorical Arena Theory (RAT) and Uses and Gratification Theory (U&G), the research addresses: (1) How did individuals in the active audience discuss challenges faced when trying to access Florida’s unemployment system? (2) What lessons can be drawn from the analysis of informal communications on social media for improving crisis communication strategies during future crises? A …