Digital Commons Network^™

Smoking And Covid-19: An Analysis Of Demographics, Risk Factors, And Outcomes, Andrew Vrtar, Luca Cucullo, Richard H. Kennedy

Posters

• Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a respiratory pathogen that first emerged in late 20191 and was declared as a pandemic by the World Health Organization (WHO) on March 11, 2020.
• Cigarette use is a significant public health concern throughout the world. Despite reductions in prevalence in recent years, tobacco smoking remains one of the main preventable causes of ill-health and premature death.
• Both tobacco smoking and vaping are phenomena that may increase the vulnerability of these individuals to COVID19 infection.4 Therefore, it is crucial to explore the medical consequences of and …

Assessing The Impact Of The Covid-19 Pandemic On Training At The Md Anderson Cancer Center Anatomical Pathology Fellowship Program, Yiannis P Dimopoulos, Donghyang Kwon, Denái R Milton, Paula I Iaeger, Donna E Hansel, Victor G Prieto, Kareen E Chin, Phyu P Aung

Faculty, Staff and Student Publications

Context: To provide high-quality, safe training during the COVID-19 pandemic, our anatomic pathology fellowship program implemented a hybrid virtual/in-person training model with supplemental digital material.

Objective: To evaluate the impact of this model.

Design: We examined Accreditation Council for Graduate Medical Education survey results and board pass rates for fellows before the pandemic (group 1); during the pandemic peak (group 2); and early and late after the pandemic peak (groups 3 and 4). Additionally, we distributed an online survey, including questions related to performance as attending physicians and fellowship experience, to recent graduates.

Results: Information loss during handover, supervision and …

Correlation Between Il-6 And Age In Covid-19: Insights From A Cross-Sectional Analysis In Malang, Indonesia, Agustin Iskandar, Dearikha Karina Mayashinta, Catur Suci Sutrisnani, Nur Samsu, Agustina Tri Endharti, Edy Widjajanto

Baghdad Science Journal

Interleukin 6 (IL-6) has been identified as a predictor of severity and mortality in COVID-19. Although morbidity and mortality generally increase with age, it remains uncertain whether there is a correlation between age and IL-6 levels, thereby exacerbating the severity of COVID-19 in patients. The objective of this study was to examine the correlation between age and IL-6 levels in COVID-19 patients. The study was cross-sectional, analyzing laboratory and medical records of 3,171 COVID-19 patients who received treatment in 2021 at Saiful Anwar General Hospital. The Data analyzed using Kruskal-Wallis, Dunnett's Post Hoc, and Spearman Correlation tests. The patients were …

Sars-Cov-2 Viral Load In The Nasopharynx At Time Of First Infection Among Unvaccinated Individuals, Leigh H Fisher, Jia Jin Kee, Albert Liu, Claudia M Espinosa, April K Randhawa, James Ludwig, Craig A Magaret, Samuel T Robinson, Peter B Gilbert, Ollivier Hyrien, James G Kublin, Nadine Rouphael, Ann R Falsey, Magdalena E Sobieszczyk, Hana M El Sahly, Beatriz Grinsztejn, Glenda E Gray, Karen L Kotloff, Cynthia L Gay, Brett Leav, Ian Hirsch, Frank Struyf, Lisa M Dunkle, Kathleen M Neuzil, Lawrence Corey, Yunda Huang, Paul A Goepfert, Stephen R Walsh, Lindsey R Baden, Holly Janes, Covid-19 Prevention Network (Covpn)

Faculty, Staff and Student Publications

Importance: SARS-CoV-2 viral load (VL) in the nasopharynx is difficult to quantify and standardize across settings, but it may inform transmission potential and disease severity.

Objective: To characterize VL at COVID-19 diagnosis among previously uninfected and unvaccinated individuals by evaluating the association of demographic and clinical characteristics, viral variant, and trial with VL, as well as the ability of VL to predict severe disease.

Design, setting, and participants: This secondary cross-protocol analysis used individual-level data from placebo recipients from 4 harmonized, phase 3 COVID-19 vaccine efficacy trials sponsored by Moderna, AstraZeneca, Janssen, and Novavax. Participants were SARS-CoV-2 negative at baseline …

The Role Of Cosmopolitan Orientation In Covid-19-Related Attitudes: Perceived Threats And Opportunities, Vaccination Willingness, And Support For Collective Containment Efforts, Angela K. Y. Leung, Brandon Koh, Verity Yu Qing Lua, James H. Liu, Sarah Y. Choi, I-Ching Lee, Michelle Lee, Mei-Hua Lin, Darrin Hodgetts, Sylvia X. Chen

Research Collection School of Social Sciences

Cosmopolitan individuals identify themselves as "citizens of the world." In the present research, we tested the idea that endorsing a cosmopolitan orientation (CO) is adaptive in the COVID-19 crisis. Cosmopolitan individuals more readily transcend national parochialism, show greater concern for all humanity, and prioritize collective interests. In a two-wave multi-region investigation with six samples from China, Hong Kong, Taiwan, Malaysia, Singapore, and the U.S., we first established longitudinal and cross-cultural measurement invariance of the CO scale. Next, we found that people with a higher CO tended to perceive over time a greater threat posed by COVID-19, take more safety measures, …

Factors Associated With The Ability Of Us Nursing Homes To Accept Residents With Severe Obesity, Cynthia Mcmahan, Bianca Shieu, Alison Trinkoff, Nicholas Castle, David G Wolf, Steven Handler, John A Harris

Faculty, Staff and Student Publications

Objectives: Severe obesity in nursing home (NH) residents is associated with specialized care needs, limited mobility, and challenges in daily living. The COVID-19 pandemic strained NH resources and exacerbated staffing shortages. This study aimed to assess the ability of US NHs to accept and care for residents with severe obesity post-COVID, as well as associated NH factors.

Design: Cross-sectional nationwide survey of NH administrators (2021-2022).

Setting and participants: 290 NHs from a national sample (n = 224) and a targeted sample in Massachusetts and New Jersey (n = 66).

Methods: A survey designed to assess how NHs approach admitting and …

Texture-Based Classification To Overcome Uncertainty Between Covid-19 And Viral Pneumonia Using Machine Learning And Deep Learning Techniques, Omar Farghaly, Priya Deshpande

Electrical and Computer Engineering Faculty Research and Publications

The SARS-CoV-2 virus, responsible for COVID-19, often manifests symptoms akin to viral pneumonia, complicating early detection and potentially leading to severe COVID pneumonia and long-term effects. Particularly affecting young individuals, the elderly, and those with weakened immune systems, the accurate classification of COVID-19 poses challenges, especially with highly dimensional image data. Past studies have faced limitations due to simplistic algorithms and small, biased datasets, yielding inaccurate results. In response, our study introduces a novel classification model that integrates advanced texture feature extraction methods, including GLCM, GLDM, and wavelet transform, within a deep learning framework. This innovative approach enables the effective …

Vitamin D Regulates Covid-19 Associated Severity By Suppressing The Nlrp3 Inflammasome Pathway, Bariaa Khalil, Narjes Saheb Sharif-Askari, Shirin Hafezi, Fatemeh Saheb Sharif-Askari, Fatme Al Anouti, Qutayba Hamid, Rabih Halwani

All Works

Background The role of vitamin D3 (VitD3) in modulating innate and adaptive immunity has been reported in different disease contexts. Since the start of the coronavirus disease-2019 (COVID-19) pandemic, the role of VitD3 has been highlighted in many correlational and observational studies. However, the exact mechanisms of action are not well identified. One of the mechanisms via which VitD3 modulates innate immunity is by regulating the NLRP3-inflammasome pathway, being a main underlying cause of SARS-CoV-2-induced hyperinflammation. Aims and main methods Blood specimens of severe COVID-19 patients with or without VitD3 treatment were collected during their stay in the intensive care …

From Form Crisis To Come Back: Reviving Education In The Era Of Covid-19, Ericka Millar

Capstone Projects and Master's Theses

The outbreak of COVID-19 in 2020 had an unprecedented impact on education worldwide. The researcher will use what they have learned to find ways in which we can help students who are falling behind in their education. Learning loss caused by COVID-19 is crucial because it has real, lasting consequences for students, and it's essential to address these issues to ensure their continued success in education. Based on a comprehensive analysis of diverse data sources, including academic literature and interviews, three potential action options emerged to address the ongoing negative repercussions of COVID-19 on upper elementary school students. Based on …

An Examination Of Superintendent Turnover In Kentucky: A Decade Of Data, Kevin Hub, Gill Hunter

Journal of Excellence in College Teaching and Learning

This study makes use of a data set detailing instances of public school superintendent turnover in Kentucky between 2014 and 2023. A quantitative research design was used to analyze descriptive statistics in the sample of 205 superintendent turnovers occurring during the identified decade. The analysis reveals a disparity between females and males selected to fill superintendent vacancies. The research also demonstrates that superintendent turnover in Appalachian and non-Appalachian school districts is proportionally consistent, as is superintendent turnover among the eight geographically-assigned Kentucky Department of Education (KDE) educational cooperatives. The findings demonstrate that applicants for superintendent positions serving as assistant superintendents …

Targeted Accurate Rna Consensus Sequencing (Tarc-Seq) Reveals Mechanisms Of Replication Error Affecting Sars-Cov-2 Divergence, Catherine C Bradley, Chen Wang, Alasdair J E Gordon, Alice X Wen, Pamela N Luna, Matthew B Cooke, Brendan F Kohrn, Scott R Kennedy, Vasanthi Avadhanula, Pedro A Piedra, Olivier Lichtarge, Chad A Shaw, Shannon E Ronca, Christophe Herman

Duncan NRI Faculty and Staff Publications

RNA viruses, like SARS-CoV-2, depend on their RNA-dependent RNA polymerases (RdRp) for replication, which is error-prone. Monitoring replication errors is crucial for understanding the virus’s evolution. Current methods lack the precision to detect rare de novo RNA mutations, particularly in low-input samples such as those from patients. Here, we introduce a new targeted Accurate RNA Consensus sequencing method (tARC-seq) to accurately determine the mutation frequency and types in SARS-CoV-2, both in cell culture and clinical samples. Our findings show an average of 2.68×10−5 new errors per cycle with a C>T bias that cannot be solely attributed to APOBEC …

Burnout And Work Fatigue In Contingent Faculty During The Covid-19 Pandemic, Gina Dimartino

Dissertations

The COVID-19 pandemic and immediate shift to remote learning had a major impact on faculty and students in higher education institutions (HEIs). As a result of the pandemic, many stakeholders in HEIs have experienced burnout and work fatigue, specifically, contingent/adjunct faculty. Contingent/adjunct faculty comprise a majority of faculty who serve students in colleges and universities across the country.

As the needs of students increased during the pandemic, contingent/adjunct faculty experienced increased workloads due to the additional support needed by diverse and challenged students. This further intensified the unique challenges faced by contingent faculty that existed prior to the pandemic in …

The Evolution Of School Leadership In Times Of Crisis, Christopher Butcher, Todd Mccardle

Journal of Excellence in College Teaching and Learning

This case study seeks to address how COVID-19 has affected principals. We approach this study through the lens of Open Systems Theory (Katz & Kahn, 1978), as we attempt to understand how school leaders understand and act during a global pandemic. This research answers the following question: How has the role of a school principal changed since the onset of COVID-19? The data reveal two emerging themes: 1) principals taking on unique caretaker roles and 2) principals increasing their focus on a managerial approach to leadership. The findings support the evolution (and devolution) of leadership approaches that school principals go …

Post-Covid Small Fiber Neuropathy, Implications Of Innate Immunity, And Challenges On Ivig Therapy, Marinos Dalakas

Department of Neurology Faculty Papers

No abstract provided.

A Content Analysis On Emotions Presented In Preschool Children's Television, Sarah Austin

All Graduate Theses and Dissertations, Fall 2023 to Present

Learning about emotions is an essential aspect of early childhood. Because of the increasing access to screen time during the COVID-19 pandemic, children have more resources in their environment to learn from. However, before more can be known about whether children are learning about emotions during their screen time, it is important to know how emotions are being presented to them in their online content. Therefore, this study sought to gather data regarding how four emotions (happiness, sadness, anger, fear) are portrayed verbally and nonverbally among three types of preschool television shows (entertainment, balanced, educational). A sample of 60 preschool …

Computationally Restoring The Potency Of A Clinical Antibody Against Omicron, Thomas A Desautels, Suzanne M Scheaffer, Bradley Whitener, James B Case, Larissa B Thackray, Michael S Diamond, Et Al.

2020-Current year OA Pubs

The COVID-19 pandemic underscored the promise of monoclonal antibody-based prophylactic and therapeutic drugs

Sars-Cov-2 Viral Load In The Nasopharynx At Time Of First Infection Among Unvaccinated Individuals: A Secondary Cross-Protocol Analysis Of 4 Randomized Trials, Leigh H Fisher, Jia Jin Kee, Albert Liu, Claudia M Espinosa, April K Randhawa, James Ludwig, Craig A Magaret, Samuel T Robinson, Peter B Gilbert, Ollivier Hyrien, James G Kublin, Nadine Rouphael, Ann R Falsey, Magdalena E Sobieszczyk, Hana M El Sahly, Beatriz Grinsztejn, Glenda E Gray, Karen L Kotloff, Cynthia L Gay, Brett Leav, Ian Hirsch, Frank Struyf, Lisa M Dunkle, Kathleen M Neuzil, Lawrence Corey, Yunda Huang, Paul A Goepfert, Stephen R Walsh, Lindsey R Baden, Holly Janes, Covid-19 Prevention Network (Covpn)

Faculty, Staff and Students Publications

IMPORTANCE: SARS-CoV-2 viral load (VL) in the nasopharynx is difficult to quantify and standardize across settings, but it may inform transmission potential and disease severity.

OBJECTIVE: To characterize VL at COVID-19 diagnosis among previously uninfected and unvaccinated individuals by evaluating the association of demographic and clinical characteristics, viral variant, and trial with VL, as well as the ability of VL to predict severe disease.

DESIGN, SETTING, AND PARTICIPANTS: This secondary cross-protocol analysis used individual-level data from placebo recipients from 4 harmonized, phase 3 COVID-19 vaccine efficacy trials sponsored by Moderna, AstraZeneca, Janssen, and Novavax. Participants were SARS-CoV-2 negative at baseline …

What Accounts For The Effect Of Sustainability Engagement On Stock Price Crash Risk During The Covid-19 Pandemic—Agency Theory Or Legitimacy Theory?, Junru Zhang, Chen Zheng, Yuan G. Shan

Research outputs 2022 to 2026

In this study, we conduct a textual analysis of the third-party disclosure of corporate sustainability news focused on the Standard and Poor's 500 firms in the United States market during the first and second quarter of 2020. We find a positive relationship between corporate sustainability news release and firm-specific stock price crash risk. This finding is surprising, but it indeed aligns with agency theory. It indicates that the coronavirus disease (COVID-19) pandemic exacerbated the tendency of managers under increasing financial pressure to use the sustainability information release as a mechanism to mask and withhold bad news for extended periods at …

Observational Analysis For Predicting Initial Spikes In Testing Volume Of Cohorts Inside And Outside Of A Regional Covid-19 Screening Program, Adam M. Franks, Seth Bergeron, Tammy Bannister, Justin Spradling, Tamara Lowe, Paris Johnson, Rajan Lamichhane, Stephen M. Petrany

Marshall Journal of Medicine

BACKGROUND Containing the highly contagious SARs-CoV-2 pathogen requires a safe and effective screening program. The aim of this observational cohort study is to analyze a regional testing center and identify factors predicting testing rates that direct supply and staffing needs.

METHODS A drive-through SAR-CoV-2 regional testing facility was created. Number of tests and positive results were collected for eighteen months. Data for testing demand was compared to positive results, percent positive rates (PPR), known external factors, and county PPR. Dissimilarities were contrasted with dynamic time warp and a detailed agreement analysis. The Grainger’s test was utilized to assess the degree …

Covid-19 In The Setting Of Hiv And Severe Hemophilia A: A Case Report, Ryan Wilson, Chae Ko, Rahul Kashyap

HCA Healthcare Journal of Medicine

Introduction

A hyperactive immune response is the driving force behind severe Coronavirus disease 2019 (COVID-19). Complications of severe COVID-19 include acute respiratory distress syndrome, acute respiratory failure, and increased risk of venous thromboembolism (VTE). The management of patients with COVID-19 includes respiratory support, decreasing immune response to the virus to prevent the progression of disease, and anticoagulation to prevent VTE.

Case Presentation

We present the case of a patient with a history of human immunodeficiency virus (HIV) and hemophilia A admitted with COVID-19. This case demonstrates the difficulties present when managing COVID-19 in patients with specific comorbidities. Anticoagulation is a …

Ischemic Colitis In A Middle-Aged Man With Covid-19: Case Report And Review Of Literature, Lara Appiah, Subhasis Misra, Stephen Jones

HCA Healthcare Journal of Medicine

Introduction

Coronavirus disease 2019 (COVID-19) was a pandemic that began in 2019 and continues to have morbid and deadly consequences throughout the world. During the beginning of the pandemic, many considered older adults and immunocompromised younger adults to be the only populations at risk for the severe consequences of COVID-19. Throughout the pandemic, this was proven wrong with several case reports and studies showing that relatively younger adults can also suffer serious consequences from this perplexing virus.

Case Presentation

We report a rare case of ischemic colitis in a 42-year-old obese man who presented to the emergency department with quintessential …

Opioid-Related Emergency Department Visits Before And During Covid-19: Association With Community-Level Factors, Timothy F. Page, Weiwei Chen, François Sainfort, Julie A. Jacko

HCA Healthcare Journal of Medicine

Background

The purpose of the study was to investigate the relationship between community-level variables and emergency department (ED) visit rates before and during COVID-19. The focus was on opioid-related ED visits. Despite large declines in overall ED visits during COVID-19, opioid-related visits increased. While visits for avoidable conditions decreased, the opposite was true for opioid-related visits.

Methods

We combined data from Florida EDs with community-level variables from the 2020 American Community Survey. The outcome measures of the study were quarterly ZIP code tabulation-area-level ED visit rates for opioid-related ED visits as well as visit rates for all other causes. Associations …

Drivers Of Being Unhoused And The Prevalence Of Health Conditions Among Unhoused Individuals In Asheville, Nc, Andrea K. Yontz, Amber Beane, Tessa Frank, Amy Upham, Dustin V. Patil, Dan Pizzo, Steve Buie, Jacqueline R. Halladay

HCA Healthcare Journal of Medicine

Background

During the COVID-19 pandemic, there was an increase in the number of unhoused individuals in Asheville, North Carolina resulting in more tent encampments.

Understanding the physical, mental, and socially determined health characteristics associated with being unhoused can help guide stakeholders with policy development, healthcare program planning, and funding decisions to support unhoused individuals.

Methods

In this study, we used an observational cross-section methodology. Using a convenience sample approach, we interviewed 101 participants who were receiving services from 2 emergency hotel shelters, a day center, and a resource center. Data were analyzed using descriptive statistics, and open-ended responses were collected …

Evaluation Of The Efficacy Of Remdesivir For The Treatment Of Coronavirus Disease 2019, Alexandra Flannery, Anastasia Knecht, Koravangala Sundaresh

HCA Healthcare Journal of Medicine

Background

Coronavirus disease 2019 (COVID-19), caused by a novel coronavirus, SARS-CoV-2, has accounted for more than 1 000 000 deaths in the United States alone. In May 2020, the Food and Drug Administration issued an Emergency Use Authorization to allow the investigational use of intravenous remdesivir for the treatment of suspected or confirmed COVID-19 in hospitalized children and adults. Several other agents, such as hydroxychloroquine, dexamethasone, and tocilizumab have been investigated as potential treatment options; however, dexamethasone is currently the only agent that has been proven to reduce mortality in patients who require supplemental oxygen. The purpose of this study …

Investigation Of The Effect Of The Covid-19 Pandemic On Anxiety Levels And Career Satisfaction Of Dentistry Students, Furkan Kır, Ata Batuhan Bayrak, Mediha Büyükgöze-Dindar

Journal of Dentistry Indonesia

Objective: This study aimed to investigate the effect of the COVID-19 pandemic on the anxiety levels and career satisfaction of dentistry students. Methods: A total of 220 dentistry students were included in the study. A questionnaire was mailed to dentistry students at Trakya University between June 2021 and January 2022. Beck Anxiety Inventory (BAI) was used to evaluate anxiety levels. Data were analyzed, and p < 0.05 was considered statistically significant. Results: The mean BAI scores of the participants were 14.6 ± 13.6. The anxiety levels of the females were significantly higher than the males (p = 0.004). There was a significant relationship …

Incorporating Institutions And Ideology: Why Covid Didn't Change Anything, Cullen Kendrick

Departmental Honors & Graduate Capstone Projects

In this paper, I investigate the aftermath of the COVID-19 pandemic through an economic and philosophical lens to try and understand why government aid was removed. Looking at the problem as solely a structural issue, with Jurgen Habermas’ Between Facts and Norms and Douglas North’s Institutions, Institutional Change, and Economic Performance guiding my understanding, provides useful insights. Namely, how the informal and formal structures of society interact, and their cyclical nature. However, that perspective does not provide a complete picture. And so, I developed an understanding of ideology to investigate the origins of informal societal structures. To do this I …

Association Of School Instructional Mode With Community Covid-19 Incidence During August–December 2020 In Cuyahoga County, Ohio, Pauline D. Terebuh, Jeffrey M. Albert, Jacqueline W. Curtis, Kurt C. Stange, Jill E. Miracle, Wail Yar, Prakash R. Ganesh, Heidi L. Gullett, Johnie Rose

Faculty Scholarship

Remote and hybrid modes of instruction were employed as alternatives to in-person instruction as part of early mitigation efforts in response to the COVID-19 pandemic. We investigated the impact of a public school district’s instructional mode on cumulative incidence and transmission in the surrounding community by employing a generalized estimating equations approach to estimate the association with weekly COVID-19 case counts by zip code in Cuyahoga County, Ohio, from August to December 2020. Remote instruction only (RI) was employed by 7 of 20 school districts; 13 used some non-remote instruction (NRI) (2–15 weeks). Weekly incidence increased in all zip codes …

Sars-Cov-2 Omicron: Viral Evolution, Immune Evasion, And Alternative Durable Therapeutic Strategies, Hailong Guo, Sha Ha, Jason W Botten, Kai Xu, Ningyan Zhang, Zhiqiang An, William R Strohl, John W Shiver, Tong-Ming Fu

Faculty, Staff and Student Publications

Since the SARS-CoV-2 Omicron virus has gained dominance worldwide, its continual evolution with unpredictable mutations and patterns has revoked all authorized immunotherapeutics. Rapid viral evolution has also necessitated several rounds of vaccine updates in order to provide adequate immune protection. It remains imperative to understand how Omicron evolves into different subvariants and causes immune escape as this could help reevaluate the current intervention strategies mostly implemented in the clinics as emergency measures to counter the pandemic and, importantly, develop new solutions. Here, we provide a review focusing on the major events of Omicron viral evolution, including the features of spike …

Impact Of The Covid-19 Pandemic On Remote Learning Among Second-Choice Homeschoolers In West Virginia: A Transcendental Phenomenology, Debra Dingess Brennan

Doctoral Dissertations and Projects

The purpose of this transcendental phenomenological study was to understand the lived experiences of second-choice homeschoolers in West Virginia with forced remote learning and homeschooling during the COVID-19 pandemic. The label second-choice homeschoolers in this research refers to homeschooling families in West Virginia who have first-hand experience with remote learning during the COVID-19 pandemic. The theory guiding this study was Bandura’s social cognitive theory, as it aligned with understanding parental homeschooling experiences by focusing on the impact of environmental events on human behavioral patterns. The central research question guiding this study was: What were the lived experiences of second-choice homeschoolers …

The Impact Of Covid-19 On Student Motivation In Secondary Instrumental Music, Martha Jane Robinson

Doctoral Dissertations and Projects

The purpose of this study was to provide strategies to improve student motivation in band and orchestra programs in Elkhart Community Schools. The problem for band and orchestra teachers was declining enrollment and student participation in outside music activities such as audition opportunities since the COVID-19 pandemic. The rationale for this study was to examine student motivation and provide educators with immediately applicable strategies to improve student participation in instrumental music programs. Educators must understand why students continued to struggle with returning to normalcy by seeking strategies as to how to reach and help these students. Early research following the …