Digital Commons Network^™

Anti-Sars-Cov-2 Nucleoprotein Iga Is Associated With Worse Disease Severity In Critically Ill Covid-19 Pneumonia Patients, David Brett-Major, Dylan S. George, Eric D. Morrell, Carmen Mikacenic, Julie Carstens, Laura E. Evans, Mark M. Wurfel, Pavan K. Bhatraju, M. Jana Broadhurst

Journal Articles: Epidemiology

While humoral responses to vaccination and infection have largely focused on IgG, there is an evolving literature on ways in which IgA may drive neutrophil activity in lung injury secondary to viral infections, including COVID-19. We evaluated 238 immune-naïve, critically ill patients in the first year of the COVID-19 pandemic. Employing a laboratory-developed, multiplexed antibody testing, clinical history, medical record, and machine learning, we pursued relationships between systemic IgA and disease severity. Individuals with elevated anti-N IgA had 4-fold odds of more severe disease. This work emphasizes the importance of continued work to understand how different elements of the immune …

Qualitative Exploration Of Covid-19 Vaccine Uptake Among Healthcare Workers In Sierra Leone: Do The ‘Trusted Messengers’ Trust The Vaccine?, Ifeolu David, Enid Schatz, Wilson Majee

Population Health Leadership and Analytics Faculty Publications and Presentations

Introduction

Vaccine hesitancy is a global issue, and the important role of healthcare workers in addressing vaccine hesitancy is well documented. However, there is limited theory-guided research on the uptake of COVID-19 vaccinations among healthcare workers in low- and middle-income countries (LMICs). This study examined COVID-19 vaccine uptake among healthcare workers in Sierra Leone and assessed the relevance of the 5C model—which posits that vaccine uptake is shaped by confidence, complacency, constraints, calculation and collective responsibility—in explaining their vaccination attitudes, intentions and behaviours.

Methods

24 indepth interviews were conducted in 2022 with healthcare workers in Freetown, Makeni and Kenema. The …

Viral Misunderstandings: Reddit Posts And The Covid-19 Infodemic, Julia C. Knutson

Scripps Senior Theses

Information epidemics or “infodemics” became the center of misinformation conversations, due to a global increase in information spread surrounding the COVID-19 pandemic. While many academic scholars and institutions, such as the World Health Organization (WHO) attribute the cause of infodemics to anti-science attitudes and the public’s lack of scientific literacy, scholars in Science, Technology, and Society argue that analyzing misinformation within these isolated bounds limits our understanding of its underlying social and historical contexts. Using the COVID-19 pandemic as a case study for misinformation analysis reveals a gap in our current understanding of how people who resonate with or spread …

Facebooking Under Crisis: A Comparative Study Of Online French And American Mutual Aid Organizing During The Covid-19 Pandemic, Clare Reimers-Hejnal

Scripps Senior Theses

This thesis studies the political discussions, practices, and projects that emerged through mutual aid Facebook groups based in France and the United States during the COVID-19 pandemic. Of particular interest is how these online spaces and the Facebook users that comprised them understood their mutual aid organizing in relationship to specific themes, including but not limited to: the COVID-19 pandemic as a "crisis", the role of government presence or absence in the wellbeing of the public, and the concept of collective yet differentiated struggle. Chapter 1 looks at four Facebook pages based in the greater Paris area: Entraide Danube, Clichy …

Understanding Addiction As A Disease: College Students’ Perspectives On Substance Use In The Covid-19 Era, Aditi Rudrashetty

Athena: Undergraduate Research and Literary Journal

This research explores the neurological basis of addiction as a disease and how the exacerbation of external factors has contributed to negative perceptions of addiction. Specifically, it examines the COVID-19 pandemic and contemporary college student experiences as contextual factors influencing attitudes toward substance use disorders. Negative perceptions contribute to stigma, reduce help-seeking behavior, and influence policy responses, hindering effective support and recovery for individuals with substance use disorders. By examining these perceptions, this study contributes to understanding how addiction is conceptualized and potentially addressed in public health and policy contexts. Surveys and semi-structured interviews were conducted with college students to …

Gene Editing And The Accessibility Of Bioterrorism: Rethinking Global Biosecurity In The Post-Covid-19 Era, Nicholas Morales

Graduate Theses/Dissertations

COVID‑19 demonstrated how a single biological event can strain health systems, disrupt supply chains, undermine national security, and erode public trust. This shock occurred as biotechnology became dramatically more accessible: gene editing and synthetic biology tools once limited to specialized laboratories are now widely available through inexpensive equipment, open‑source data, and decentralized expertise.

This expanded access accelerates innovation but also broadens the threat landscape. The ability to reconstruct pathogens using publicly available sequences and mail‑order DNA shows that complex biological synthesis is no longer confined to state programs. These risks are amplified by opaque biotechnology activities in China, Russia, and …

The Differential Impacts Of Internal And External Corporate Social Responsibility Activities On Consumer Trust After Covid-19, Kennadi C. Mccoy

Graduate Theses, Dissertations, and Problem Reports (ETD)

This dissertation explores the strategic role of Corporate Social Responsibility (CSR) in helping small businesses recover from crises, with a specific focus on the COVID-19 pandemic. Different from many traditional studies that highlight the ethical or reputational aspects of CSR, this research will examine its practical effects: how CSR initiatives during crises influence business success by enhancing consumer trust, particularly by examining the differential impact of Internal CSR versus External CSR. The study suggests that, compared with internally focused CSR, external CSR activities will have a greater impact on consumer trust. In addition, the dissertation suggests that this effect is …

If I Only Had The Words (To Tell You): Billy Joel Lyrics In Legal And Medical Scholarship, Seuli Bose Brill, Christian H. Brill

Touro Law Review

Law and medicine are often considered to be among the least accessible professions, partly because of the heavy use of non colloquial jargon. This article examines more than 150 instances in which Billy Joel’s lyrics have been used to improve the accessibility of legal and medical scholarship. Legal and medical professionals have used the words of the “Piano Man” to discuss a variety of topics—everything from civil procedure to property rights and the COVID-19 pandemic to colorectal surgery. Nontraditional communications techniques of this type do not just contribute to the body of legal and medical scholarship; they also help professionals …

Recalibrating Readiness: Pandemic Impact On Ot Admissions, Bridget J. Hahn, Kajol Patel, Jacquelyn A. Siegel, Jessica Rappaport, Michelle Mcfall-Johnsen, Kia A. Burks

Journal of Occupational Therapy Education

This study explored shifts in occupational therapy applicant characteristics across two distinct time periods: pre- and post-COVID-19, while also describing admissions policy changes implemented by an urban Midwestern Occupational Therapy Doctorate (OTD) program. Retrospective data from admissions records from 917 applicants (2017 – 2024) were grouped into pre-COVID (2017 – 2020) and post-COVID (2021 – 2024). Academic, pre-professional, interview, and underrepresented minority (URM) status was compared using independent t-tests and chi-square analyses. Cumulative grade point average (GPA) and research experience increased post-pandemic, while pre-professional experience and interview performance declined. The proportion of URM applicants rose significantly from 8.1% pre-COVID to …

“Black Students Matter”: A Phenomenological Study Of Black Student Experiences At A Predominately White Institution In Appalachia During The Dual Pandemic Of Covid-19 And Systemic Anti-Black Racism, Toni Owens

Graduate Theses, Dissertations, and Problem Reports (ETD)

As the spread of COVID-19 escalated into a global pandemic in 2020, simultaneously, the nationwide media in the United States (U.S.) highlighted coverage of the country’s ongoing incidents of longstanding systemic anti-Black racism in America, another pandemic. In the Summer of 2020, a collective of Black students at West Virginia University (WVU) signed and publicly submitted a petition to the university’s leadership with a list of demands to address their needs as they were further exacerbated by the dual pandemic. This study is guided by the question, “What are the lived experiences of Black Students at West Virginia University during …

How Did Covid-19 Affect Volunteer And Donor Management For Human Services Agencies? What Are The Lessons For Future Response?, Nina Yon

Graduate Studies Theses and Dissertations 2026

The COVID-19 pandemic created unprecedented challenges for human services agencies, disrupting the interdependent systems of volunteer engagement and donor support essential to nonprofit sustainability. This study integrates insights from literature, theory, and empirical analysis to examine how nonprofit organizations adapted their volunteer and donor management strategies during this prolonged crisis. Drawing on Contingency Theory and Resource Dependence Theory (RDT), the research explores how organizational structures and strategies evolved in response to shifting environmental conditions, health mandates, and resource constraints. Using a multiple-case qualitative design, data was collected from semi-structured interviews with 20 leaders representing five Central Florida human services agencies, …

Exploring The Use Of Strategic Influencer Leadership (Sil) In Health Communication: A Cross-Cultural, Multi-Case Study, Katharina Wolf, Catherine Archer, Syafiq B. Assegaff, Joseph Nalloor

Research outputs 2022 to 2026

Purpose This study challenges the social media-centric view of influencers, arguing that health communication benefits from diverse strategic influencers beyond commercial figures. Trust, credibility and cultural resonance are essential for effective public health messaging, yet contemporary approaches often prioritise engagement metrics over strategic influence. Design/methodology/approach This paper employs a multi-case study approach to examine the strategic use of influencers in health communication across Indonesia, the United Arab Emirates and Australia during the COVID-19 pandemic. It explores how health professionals, royal representatives and a politician shaped public health messaging within culturally specific contexts. A mixed-methods approach, incorporating ethnographic research and thematic …

Using Medication Pass Analysis To Examine Longitudinal Changes In Va Inpatient Nurse Staffing And Workload Before And Through The Covid-19 Pandemic: 2019-2022, Melissa K Knox, Chase S Eck, Lynette Dorsey, Paras D Mehta, Christine Yang, Laura A Petersen

Faculty, Staff and Students Publications

Background: The COVID-19 pandemic resulted in extended disruption to the health care system. National-level data-driven comparisons of inpatient nurse staffing and workload before and during the pandemic have been limited.

Objectives: Assess the extent to which registered nurse (RN) staffing and workload changed from prepandemic levels in a national integrated health care system.

Research design: Longitudinal descriptive analysis. Medication pass analysis using bar code medication administration data for the peak-time medication pass (PTM) assessing year-over-year changes from 2019 to 2022. To assess significance of year-over-year changes in means we used the Welch 2-sample t test.

Subjects: Staff (N=42,999) administering PTM …

Karanasan Ng Piling Pamilyang Pilipino Sa Panahon Ng Pandemya: Alaala Ng Enhanced Community Quarantine Sa Metro Manila, Glenda D. Salorsano

Social Sciences and Development Review

The global spread of COVID-19 has become a worldwide phenomenon. Every country faced different challenges brought by the pandemic in which highlighted the strengths and weaknesses of each nation in combating the virus. It not only became a widespread blow to the health sector but also paved the way for the revelation of other social aspects that need attention. This occurrence allowed the concrete identification of other deficiencies in crucial sectors of society that are associated with pandemic response. These include infrastructure, public transportation, public safety, human rights, and access to sufficient and proper food for every family, and financial …

Virtual Teaching During Covid-19: Attitudes, Abilities, And Educational Needs Of Cooperative Extension Staff, Kathryn Yerxa, Kayla L. Parsons, Jennifer Lobley

Journal on Empowering Teaching Excellence

Access the online Pressbooks version of this introduction here.

This study aimed to 1) identify the attitudes and abilities of Cooperative Extension staff regarding the delivery of virtual educational programming based on their characteristics and 2) identify professional development priorities to effectively deliver programming virtually. We disseminated an adapted Faculty Readiness to Teach Online questionnaire to Cooperative Extension staff via Qualtrics. Mean and standard deviation were calculated from complete surveys (n = 67) for each virtual programming competency in the self-reported attitude and ability sections, categorized by position type, years of teaching, and program area. We conducted a MANCOVA to …

Impact Of The Covid-19 Outbreak On The Emotional Responses And Self-Protective Behaviors Of Nursing Students., Banisha Lyngdoh Nonglait, Jyothsna Jennifer Hans, S P Sagar, Gayatri Poojari, Sanju Pant, Maria Pais Dr

Manipal Journal of Nursing and Health Sciences

Background: The COVID-19 pandemic has disrupted nearly every aspect of our society. The higher education sector is no exception. Students face an increasingly unstable environment, impacting their physical and emotional health.

Objectives: The study aims to determine students' emotional responses to the impacts of the COVID-19 outbreak. It also assesses their behavior in protecting themselves from cross-contamination during this period.

Methods: A descriptive survey design was used in this study, which included 61 undergraduate students. To collect data, researchers employed socio-demographic questionnaires alongside a structured attitude survey designed to assess emotional responses and self-protective behaviors related to COVID-19. The reliability …

Public Perception About Covid-19 Vaccine Hesitancy In South Central Nebraska, Rita Nnenne Oparaocha

Biology Theses, Dissertations, and Student Creative Activity

The COVID-19 pandemic created a shift in the trajectory of vaccination hesitancy, altering risk perceptions and vaccination attitudes among individuals in rural communities. The 5C framework highlights confidence, complacency, constraints, calculation, and collective responsibility as influencing factors of vaccine hesitancy. This study assessed the proportion of adults who refused COVID-19 vaccination and identified the individual reasons for hesitancy among those who refused the COVID -19 vaccines in South Central Nebraska. Data was analyzed from a local cross-sectional public health survey administered to 2,034 adult participants over a six-month period (March-August 2024), including 91 respondents who were from outside the seven-county …

The Impact Of The Covid-19 Pandemic On Middle School Educators And The Need For Healthy Coping Techniques: A Transcendental Phenomenological Study, Dionne E. Mitchell

Doctoral Dissertations and Projects

In this transcendental phenomenological study, the researcher investigated how the Coronavirus Disease (COVID-19) pandemic impacted public middle school educators’ mental health and well-being (MHWB) and how they developed effective coping strategies in response. Using Lazarus and Folkman’s transactional stress and coping theory model and the social support theory as frameworks, the study explored the lived experiences of ten middle school instructors from the southeastern United States who taught during the COVID-19 pandemic. Semi-structured interviews, a focus group, and reflective diary entries were implemented as data collection methods. Thematic analysis identified several significant findings. Teachers faced professional challenges as they adapted …

Markets We Thought We Knew, Nicole J. Olynk Widmar, Michael L. Smith, Erin Robinson

Purdue University Press Books

Markets We Thought We Knew explores the evolving nature of markets and how they shape—and are shaped by—consumer behavior. From essential life necessities such as water to everyday commodities and products including locally sourced foods, this book covers a variety of topics and invites readers to examine a diverse range of markets through a reflective lens. By revisiting past market dynamics and real-world examples, readers are encouraged to rethink how preferences are formed, how opinions shift over time, and how value is assigned—sometimes in unexpected ways. What insights might you gather from a deeper understanding of local and global markets, …

Covid-19 Vaccine Acceptance Among People Who Smoke In Rural Southwest Georgia: Perspectives And Influencing Factors, Shadé Owolabi, Helen Singer, Katherine Reilly, Łucja T. Bundy Ma-Edm, J.K. Veluswamy, Carla Berg, Regine Haardörfer, James Hotz, Ajay Gehlot, Michelle Kegler

Journal of the Georgia Public Health Association

Background: The COVID-19 vaccine is a critical tool in reducing COVID-19 related morbidity and mortality. Unfortunately, vaccine hesitancy is an ongoing public health challenge, especially in certain geographic areas and sub-populations. This study assessed factors associated with COVID-19 vaccine uptake and hesitancy among individuals who smoke in rural communities in southwest Georgia, one of the first COVID-19 “hot spots” in the U.S.

Methods: We conducted qualitative interviews (n=23) using a semi-structured interview guide, informed by the Integrated Behavioral Model (IBM), that assessed vaccine-related behavior, intention to be vaccinated, perceived risk, social norms, attitudes, and environmental barriers and facilitators …

The Use Of Storytelling In Covid-19 Vaccine Promotion: A Scoping Review Of Interventions And Campaigns, Suha Ballout, Sabreen A. Darwish, Patricia J. Kelly, Teresa Keller, Ross Shegog, Basil H. Aboul-Enein

College of Nursing Faculty Papers & Presentations

BACKGROUND: The development of the COVID-19 vaccine, a groundbreaking scientific advancement, also fueled vaccine hesitancy mainly due to vaccine misinformation and the limited public understanding of the new technology and its rapid pace of development and deployment. A variety of public health communication strategies have been used that include engaging the community in identifying and developing messages, using culturally appropriate communication methods, applying behavioral health principles, and storytelling. The purpose of this scoping review was to assess the most relevant evidence from the research literature on storytelling interventions to mitigate COVID vaccine hesitancy during the pandemic.

METHODS: A scoping review …

Emergency Lending By The Federal Reserve, Kathryn Judge, Richard Clarida

Faculty Scholarship

The Federal Reserve established an array of innovative emergency lending facilities during the Great Financial Crisis and expanded the scope of its emergency lending yet further in response to the Covid-19 pandemic. This Article provides a retrospective of how the Federal Reserve used its emergency lending authority across these two episodes, identifying patterns and revealing some differences. It sheds light on the conditions that enabled the Federal Reserve to establish the facilities that it did, including the roles played by Congress and Treasury in providing the equity funding that made certain facilities possible. It shows how in each episode, the …

The Impact Of The Covid-19 Pandemic On National Hockey League Fan Attendance, Ramon E. Rivera

Electronic Theses, Projects, and Dissertations

The COVID-19 pandemic struck swiftly around the world, causing several societal functions and normalcies to adapt or shut down completely. This culminating project explores the effects of COVID-19 on arena fan attendance of the National Hockey League (NHL). This project was guided by the following three research questions: Q1 – How did the NHL arena closures affect fan attendance during the COVID-19 pandemic? Q2 – What factors influenced NHL fan arena attendance before the start of the COVID-19 pandemic? Q3 – What factors impacted the NHL arena fan attendance after the conclusion of the COVID-19 pandemic? An empirical model developed …

Public Health Trade-Offs During A Pandemic: Mobility Decline And Hypertension Risk In India, Arpita Khanna, Tomoki Fujii

Research Collection School Of Economics

The Covid pandemic dramatically altered patterns of daily life, particularly through widespread declines in mobility due to lockdowns and social distancing measures. While the economic and epidemiological effects of these restrictions have been widely studied, their broader health implications remain underexplored. This paper investigates the relationship between mobility decline during the Covid pandemic and hypertension outcomes in India. Leveraging district-level variation in mobility from Google Community Mobility Reports and health data from the 2019–2021 Indian Demographic and Health Survey (DHS), we find that a 1 percentage point reduction in mobility over the 30 days prior to interview is associated with …

Sars-Cov-2 Rna-Binding Protein Suppresses Extracellular Mirna Release, Hyejin Mun, Chang Hoon Shin, Qingxuan Fei, Andrea Estefania Lopez Giraldo, Kyoung-Min Choi, Ji Won Lee, Kyungmin Kim, Kyung-Won Min, Leilei Shi, Mark T Bedford, Dong-Chan Kim, Yoo Lim Chun, Seonghyun Ryu, Dongin Kim, Jeong Ho Chang, Ryan T Westrope, Michelle Shay, Edward Nguyen, Junho K Hur, Abigail Agyenda, Nam Chul Kim, Sung-Ung Kang, Woonghee Lee, Je-Hyun Yoon

Faculty, Staff and Student Publications

SARS-CoV-2 is the betacoronavirus causing the COVID-19 pandemic. Although the SARS-CoV-2 genome and transcriptome were reported previously, the function of individual viral proteins is largely unknown. Utilizing biochemical and molecular biology methods, we identified that four SARS-CoV-2 RNA-binding proteins (RBPs) regulate the host RNA metabolism by direct interaction with mature miRNA let-7b revealed by Nuclear Magnetic Resonance spectroscopy (NMR). SARS-CoV-2 RBP Nsp9 primarily binds mature miRNA let-7b, a direct ligand of the Toll-like Receptor 7 (TLR7), one of the potential SARS-CoV-2 therapeutics. Nsp9 suppresses host gene expression possibly by promoting let-7b-mediated silencing of a cellular RNA polymerase, POLR2D. In addition, …

Association Of Area Deprivation Index With Perinatal And Covid-19 Outcomes During The Early Pandemic: A Secondary Analysis Of A Prospective Cohort Study, Abigail Bell, Megan Foeller, Candice Woolfolk, Emily Diveley, Fan Zhang, Amy Scheffer, Ruizhi Huang, Daniel Jackson, Nandini Raghuraman, Ebony Carter, Indira U Mysorekar, Jeannie C Kelly

Center on Aging Staff Publications

Objective: We sought to evaluate the relationship between neighborhood-level deprivation and perinatal outcomes, particularly preterm birth, as well as COVID-19 outcomes among pregnant patients during the early pandemic.

Methods: We performed a secondary analysis of a prospective longitudinal cohort study that investigated the impact of prenatal COVID-19 exposure on perinatal outcomes. Pregnant patients were recruited 12/23/20-7/18/22 and serially assessed for COVID-19 exposure during pregnancy, with serum antibody testing, electronic medical record review, and patient report. For this secondary analysis, address at the time of delivery was used to categorize patients into low ADI (≤50th percentile Area Deprivation Index, indicating low …

Where, How, And How Much? A Multicenter Cohort Study Of The Relationship Across Lupus Decision-Aid Modality, Place Of Administration, Interruption And Viewing Completeness, And Patient-Reported Outcomes, Jasvinder A Singh, Mark Beasley, Larry R Hearld

Faculty, Staff and Students Publications

Objective: We assessed whether shared decision-making (SDM) and patient acceptability, feasibility, and overall satisfaction with a computerized patient decision aid (PtDA) for patients with systemic lupus erythematosus (SLE) differs by PtDA setting, modality, and the viewing experience.

Methods: Patients with SLE were invited to view a self-administered computerized SLE PtDA during regular clinic visits at 15 rheumatology clinics in an implementation trial. Patients completed a survey that included SDM measures including the decision conflict scale (DCS), Preparation for Decision Making (PDM) scale, and CollaboRATE scale, and we measured perceived patient acceptability, feasibility, and satisfaction. Patients viewed the SLE PtDA in …

Modeling Reemergence Of Vaccine-Eliminated Infectious Diseases Under Declining Vaccination In The United States, Mathew V Kiang, Kate M Bubar, Yvonne Maldonado, Peter J Hotez, Nathan C Lo

Faculty, Staff and Students Publications

(Abstracted from JAMA 2025;333(24):2176-2187) The development of childhood vaccine protocols has led to the elimination of many infectious diseases from the United States, including measles, rubella, diphtheria, and polio, by maintaining herd immunity. In recent years, especially since the COVID-19 pandemic, vaccination rates have declined due to policy changes, misinformation, distrust, and broader societal shifts.

Association Of Area Deprivation Index With Perinatal And Covid-19 Outcomes During The Early Pandemic: A Secondary Analysis Of A Prospective Cohort Study, Abigail Bell, Megan Foeller, Candice Woolfolk, Emily Diveley, Fan Zhang, Amy Scheffer, Ruizhi Huang, Daniel Jackson, Nandini Raghuraman, Ebony Carter, Indira U Mysorekar, Jeannie C Kelly

2020-Current year OA Pubs

OBJECTIVE: We sought to evaluate the relationship between neighborhood-level deprivation and perinatal outcomes, particularly preterm birth, as well as COVID-19 outcomes among pregnant patients during the early pandemic.

METHODS: We performed a secondary analysis of a prospective longitudinal cohort study that investigated the impact of prenatal COVID-19 exposure on perinatal outcomes. Pregnant patients were recruited 12/23/20-7/18/22 and serially assessed for COVID-19 exposure during pregnancy, with serum antibody testing, electronic medical record review, and patient report. For this secondary analysis, address at the time of delivery was used to categorize patients into low ADI (≤50

RESULTS: 306 patients were included: 124 …

The Relationship Between Socioecological Factors And Resilience Among Urban Workers During The Covid-19 Pandemic, Puttaporn Onkhamsee, Sukanya Tantiprasoplap,, Wanna Sanongdej

Jurnal Keperawatan Indonesia

The global outbreak occasioned by the coronavirus disease 2019 (COVID-19) has affected people of working age in urban communities, both socially and psychologically, making resilience an important aspect of efforts to cope with such a crisis. Against this backdrop, this study identified and investigated the socioecological factors associated with the resilience of employable urban residents against the COVID-19 pandemic as part of a conceptual framework that encompasses individual, family, and community resilience. This cross-sectional research involved 368 working-age individuals recruited via simple randomization from communities in seven areas in central Bangkok. Data were collected through a questionnaire survey and examined …