Digital Commons Network^™

Body Mass Index And Postacute Sequelae Of Sars-Cov-2 Infection In Children And Young Adults, Ting Zhou, Chongliang Luo, Et Al.

2020-Current year OA Pubs

IMPORTANCE: Obesity is associated with increased severity of COVID-19. Whether obesity is associated with an increased risk of post-acute sequelae of SARS-CoV-2 infection (PASC) among pediatric populations, independent of its association with acute infection severity, is unclear.

OBJECTIVE: To quantify the association of body mass index (BMI) status before SARS-CoV-2 infection with pediatric PASC risk, controlling for acute infection severity.

DESIGN, SETTING, AND PARTICIPANTS: This retrospective cohort study occurred at 26 US children's hospitals from March 2020 to May 2023 with a minimum follow-up of 179 days. Eligible participants included children and young adults aged 5 to 20 years with …

Hospital Strain During The Covid-19 Pandemic And Outcomes In Older Racial And Ethnic Minority Adults, Laurent G Glance, Karen E Joynt Maddox, Patricia W Stone, E Yoko Furuya, Jingjing Shang, Mark J Sorbero, Ashley Chastain, Stewart J Lustik, Andrew W Dick

2020-Current year OA Pubs

IMPORTANCE: Marginalized populations have been disproportionately affected by the COVID-19 pandemic. Critically ill patients belonging to racial and ethnic minority populations treated in hospitals operating under crisis or near-crisis conditions may have experienced worse outcomes than White individuals.

OBJECTIVE: To examine whether hospital strain was associated with worse outcomes for older patients hospitalized with sepsis and whether these increases in poor outcomes were greater for members of racial and ethnic minority groups compared with White individuals.

DESIGN, SETTING, AND PARTICIPANTS: In this cross-sectional study, multivariable regression analysis was conducted to assess differential changes in all-cause 30-day mortality and major morbidity …

Isolating Microbes From The Surface Of An Introductory Laboratory Halite Hand Sample, Kesley G. Banks, Michael A. Gibson, Matthew A. Pritchett

The Compass: Earth Science Journal of Sigma Gamma Epsilon

Introductory geology labs stress simple physical testing (luster, hardness, etc.) to identify common minerals, using mineral charts to eliminate minerals not exhibiting a particular property. Special properties (magnetism, specific gravity, taste, etc.) for specific minerals narrows mineral identity. Students often express safety concerns about licking minerals, especially when they realize others have previously licked the specimen. As an exercise in medical geology, we cultured microbes from a halite sample used for nearly 25 years and licked by numerous students over that time span (Sample 1), a commercially purchased unused and freshly exposed surface of halite licked by one person (Sample …

High Fat, High Sucrose Diet Promotes Increased Expression Of Ace2 Receptor In The Siv-Infected Host: Implications For Sars-Cov-2 Infection, Elizabeth C. Delery, Danielle E. Levitt, Angela M. Amedee, Patricia E. Molina, Liz Simon

School of Graduate Studies Faculty Publications

Introduction: People with pre-existing conditions, including metabolic comorbidities, are at greater risk for complications of SARS-CoV-2 infection and expression of machinery required for viral entry into host cells may be a contributing factor. This study tested the hypothesis that high fat, high sucrose diet (HFSD) and alcohol use increase expression of angiotensin converting enzyme 2 (ACE2) receptor and transmembrane serine protease 2 (TMPRSS2) in tissues isolated from simian immunodeficiency virus (SIV) infected macaques, the most clinically relevant model for the study of HIV. Methods: Biospecimens obtained from a longitudinal study of SIV-infected, antiretroviral therapy (ART)-treated female rhesus macaques (Macaca mulatta) …

An Exploration Of Turnover Intentions Of Substance Abuse Treatment Rns During The Covid-19 Pandemic: A Qualitative Study, Ciara Patrice Jones

Doctoral Dissertations and Projects

The COVID-19 pandemic has affected nurses working in many different settings. As they were frequently the last personnel left at the frontline during COVID-19, nurses’ experiences provide distinctive narratives in the alcohol and other drug treatment workforce. Since the COVID-19 pandemic, nurses working in a substance abuse treatment setting have experienced significantly increased stressors, including fear and anxiety, the lack of personal protective equipment (PPE), and a lack of workforce sustainability. Therefore, this generic qualitative study explored the perceptions and experiences of nurses working in a substance abuse treatment program on the barriers in their workforce that influence their turnover …

Exploring Barriers To Effective Covid-19 Risk Mitigation, Recovery, And Chronic Disease Self-Management: A Qualitative Multilevel Perspective, Gayenell S. Magwood Phd, Rn, Faha, Faan, Charles Ellis, Chanita Hughes Halbert, Ebony Allen Toussaint, Jewel Scott Phd, Rn, Fnp-C, Lynne S. Nemeth

Publications

INTRODUCTION: Many research activities have focused on SARS-CoV-2 infection and subsequent COVID-19 respiratory illness during the pandemic. However, significant racial inequities emerged months after the COVID-19 pandemic began. The similarity between racial/ ethnic disparities in COVID-19 and those for other diseases raised awareness about the context for risk exposure and healthcare access. The purpose of this study is to examine social and structural determinants of health among COVID-19 survivors, carepartners, and the perspectives of healthcare stakeholders who experienced disruption during the early pandemic. MATERIAL AND METHODS: A purposive sample of interviews (n=9) and focus groups (n=10) were used to collect …

Exploring Barriers To Effective Covid-19 Risk Mitigation, Recovery, And Chronic Disease Self-Management: A Qualitative Multilevel Perspective, Gayenell S. Magwood Phd, Rn, Faha, Faan, Charles Ellis Jr, Chanita Hughes Halbert, Ebony Allen Toussaint, Jewel Scott Phd, Rn, Fnp-C, Lynne S. Nemeth

Faculty Publications

Introduction: Many research activities have focused on SARS-CoV-2 infection and subsequent COVID-19 respiratory illness during the pandemic. However, significant racial inequities emerged months after the COVID-19 pandemic began. The similarity between racial/ ethnic disparities in COVID-19 and those for other diseases raised awareness about the context for risk exposure and healthcare access. The purpose of this study is to examine social and structural determinants of health among COVID-19 survivors, carepartners, and the perspectives of healthcare stakeholders who experienced disruption during the early pandemic.
Material and methods: A purposive sample of interviews (n=9) and focus groups (n=10) were used to collect …

Examining The Influence Of Students’ Mental Health Problems On Their Social And Emotional Health: Perspectives Of Counselors And Mental Health Therapists In A Post-Pandemic World, Brandi Leigh Newsom

Student Theses and Dissertations

Examining the Influence of Students’ Mental Health Problems on Their Social and Emotional Health: Perspectives of Counselors and Mental Health Therapists in a Post-Pandemic World This qualitative phenomenological study explored the influence mental health issues have on social emotional learning in the public-school setting. The problem addressed in this study was the increased need for mental health resources and awareness in the school setting. By assessing the perspectives of school counselors and mental health therapists, awareness and resources can help students who are struggling with social-emotional needs. The guiding theoretical framework that served as the basis for this study was …

News Frames For Covid-19 – A Comparison Of Australian (Australian Broadcasting Corporation) And Vietnamese (Tuoi Tre Online) Online News Services In Two Key Weeks In 2020, Viet T. Le, Lelia Green

Research outputs 2022 to 2026

This article investigates the differences and similarities between the news frames used by online mainstream media in Vietnam and Australia when reporting COVID-19 in the early waves of the pandemic. The project uses constant comparative analysis to interrogate data gathered from two online news sources: ABC Online (Australian Broadcasting Corporation) in Australia, and Tuoi Tre Online in Vietnam. The article concludes that the Australian Broadcasting Corporation coverage focuses more on social, political and economic factors than is the case with Tuoi Tre Online, which foregrounds civic responsibility in response to the COVID-19 epidemic. The Australian Broadcasting Corporation highlights how COVID-19 …

Wstrzymanie Na Podstawie Art. 31za Ustawy Z 2 Marca 2020 R. O Szczególnych Rozwiązaniach Związanych Z Zapobieganiem, Przeciwdziałaniem I Zwalczaniem Covid-19, Innych Chorób Zakaźnych I Wywoływanych Nimi Sytuacji Kryzysowych Biegu Terminów Dokonania Czynności Przez Komisję Nadzoru Finansowego W Ramach Nadzoru Nad Rynkiem Finansowym, Joanna Róg-Dyrda

internetowy Kwartalnik Antymonopolowy i Regulacyjny (internet Quarterly on Antitrust and Regulation)

The aim of this article is to analyze the issue of suspending deadlines for actions to be taken by the Polish Financial Supervision Authority in the area of financial supervision based on Article 31za of the Act of 2 March 2020 on Special Solutions Related to the Prevention, Counteracting and Combating COVID-19, Other Infectious Diseases, and Crisis Situations Caused by them (Covid-19 Act). The article focuses on interpretive doubts that have arisen in jurisprudence and the effects of regulations on legal certainty.

The Il-6 Hypothesis In Covid-19: A Phase 2, Randomised, Double-Blind, Placebo-Controlled Study To Evaluate The Efficacy And Safety Of Free Il-6 Sequestration By The Monoclonal Antibody Sirukumab In Severe And Critical Covid-19, Robert L. Gottlieb, Meredith Clement, Paul Cook, Audra Deveikis, Kap Sum Foong, Philip Robinson, Jihad Slim, Cedric W. Spak, Annemie Buelens, Katleen Callewaert, Sandra De Meyer, Wai Ling Mo, Inge Verbrugge, Liesbeth Van Wesenbeeck, Yanli Zhuang, Jason W. Chien, Magda Opsomer, Erika Van Landuyt

School of Medicine Faculty Publications

Background: Upregulation of IL-6 has been associated with worse prognosis in COVID-19 patients. Impact on IL-6 signalling has mostly been limited to clinical outcomes in IL-6 receptor antagonist trials. Methods: We performed a phase 2, randomised, double-blind, placebo-controlled trial (NCT04380961) of US-based hospitalised adults (< 85 years) with laboratory-confirmed SARS-CoV-2 infection and severe (low levels of supplemental oxygen) or critical disease (high levels of oxygen supplementation). Patients received sirukumab 5 mg/kg or placebo single dose IV on Day 1 plus standard of care. The primary endpoint was time to sustained clinical improvement up to Day 28 based on an ordinal scale. Secondary endpoints included clinical improvement, all-cause mortality, and safety. Following an interim analysis, the protocol was amended to only recruit patients with critical COVID-19. Findings: From May 2020 to March 2021, 209 patients were randomised; 112 had critical disease (72 sirukumab, 40 placebo) at baseline. Median time to sustained clinical improvement in critical patients was 17 and 23 days in the sirukumab and placebo groups (HR, 1∙1; 95% CI, 0∙66–1∙88; p > 0∙05). At Day 28, 59∙4% versus 55∙0% of patients achieved clinical improvement with sirukumab versus placebo and rates of all-cause mortality were 24∙6% versus 30∙0%, respectively. Rates of grade ≥ 3 adverse events were comparable between the sirukumab and placebo groups (25∙9% vs 32∙9%; all patients). Interpretation: In critical COVID-19 patients who received sirukumab, there …

Panel Stacking Is A Threat To Consensus Statement Validity, Kasper P Kepp, Preben Aavitsland, Marcel Ballin, Francois Balloux, Stefan Baral, Kevin Bardosh, Howard Bauchner, Eran Bendavid, Raj Bhopal, Daniel T Blumstein, Paolo Boffetta, Florence Bourgeois, Adam Brufsky, Peter J Collignon, Sally Cripps, Ioana A Cristea, Nigel Curtis, Benjamin Djulbegovic, Oliver Faude, Maria Elena Flacco, Gordon H Guyatt, George Hajishengallis, Lars G Hemkens, Tammy Hoffmann, Ari R Joffe, Terry P Klassen, Despina Koletsi, Dimitrios P Kontoyiannis, Ellen Kuhl, Carlo La Vecchia, Tea Lallukka, John Lambris, Michael Levitt, Spyros Makridakis, Helena C Maltezou, Lamberto Manzoli, Ana Marusic, Clio Mavragani, David Moher, Ben W Mol, Taulant Muka, Florian Naudet, Paul W Noble, Anna Nordström, Peter Nordström, Nikolaos Pandis, Stefania Papatheodorou, Chirag J Patel, Irene Petersen, Stefan Pilz, Nikolaus Plesnila, Anne-Louise Ponsonby, Manuel A Rivas, Andrea Saltelli, Manuel Schabus, Michaéla C Schippers, Holger Schünemann, Marco Solmi, Andreas Stang, Hendrik Streeck, Joachim P Sturmberg, Lehana Thabane, Brett D Thombs, Athanasios Tsakris, Simon N Wood, John P A Ioannidis

Faculty, Staff and Student Publications

Consensus statements can be very influential in medicine and public health. Some of these statements use systematic evidence synthesis but others fail on this front. Many consensus statements use panels of experts to deduce perceived consensus through Delphi processes. We argue that stacking of panel members toward one particular position or narrative is a major threat, especially in absence of systematic evidence review. Stacking may involve financial conflicts of interest, but nonfinancial conflicts of strong advocacy can also cause major bias. Given their emerging importance, we describe here how such consensus statements may be misleading, by analyzing in depth a …

Lessons Learnt From Broad-Spectrum Coronavirus Antiviral Drug Discovery, Andrew A Bolinger, Jun Li, Xuping Xie, Hongmin Li, Jia Zhou

Faculty, Staff and Student Publications

Introduction: Highly pathogenic coronaviruses (CoVs), such as severe acute respiratory syndrome CoV (SARS-CoV), Middle East respiratory syndrome CoV (MERS-CoV), and the most recent SARS-CoV-2 responsible for the COVID-19 pandemic, pose significant threats to human populations over the past two decades. These CoVs have caused a broad spectrum of clinical manifestations ranging from asymptomatic to severe distress syndromes (ARDS), resulting in high morbidity and mortality.

Areas covered: The accelerated advancements in antiviral drug discovery, spurred by the COVID-19 pandemic, have shed new light on the imperative to develop treatments effective against a broad spectrum of CoVs. This perspective discusses strategies and …

A Prospective Cohort Study Of Pregnancy Outcomes Following Antepartum Infection With Sars-Cov-2, James D Doss, Emily Diveley, Fan Zhang, Amy Scheffer, Ruizhi Huang, Daniel Jackson, Nandini Raghuraman, Ebony B Carter, Indira U Mysorekar, Jeannie C Kelly

Faculty, Staff and Students Publications

Objectives: Our study aimed to explore the impact of COVID-19 infection on pregnancy outcomes, accounting for the progression of variants, vaccines, and treatment modalities.

Study design: We performed a prospective longitudinal cohort study at two urban tertiary centers enrolling patients with a confirmed intrauterine singleton pregnancy from December 23, 2020 to July 18, 2022. Patients were evaluated for SARS-CoV-2 infection at enrollment and every trimester using serum antibody testing. The primary outcome was preterm birth. Symptom and treatment data were collected from pregnant patients with COVID-19 infections. Variant strain infection status was determined from local wastewater analysis.

Results: 448 patients …

Covid-19 Infection Wave Mortality From Surveillance Data In The Philippines Using Machine Learning, Julius Migriño Jr, Ani Regina U. Batangan, Rizal Michael R. Abello

Ateneo School of Medicine and Public Health Publications

The Philippines had several COVID-19 infection waves brought about by different strains and variants of SARS-CoV-2. This study aimed to describe COVID-19 outcomes by infection waves using machine learning. A cross-sectional surveillance data review design was employed using the DOH COVID Data Drop dataset as of September 24, 2022. The predominant variant(s) of concern divided the dataset into time intervals representing the infection waves: ancestral (A0), Alpha/Beta (AB), Delta (D), and Omicron (O). Descriptive statistics and machine learning models were generated from each infection. The final data set consisted of 3,896,206 cases wherein 98.39% of cases recovered while 1.61% died. …

The Prospect Of Indonesian Herbal As An Alternative Treatment For Covid-19 Patient: A Literature-Based Study, Hadi Sunaryo, Wahyu Hidayati

Indonesian Journal of Medical Chemistry and Bioinformatics

Coronavirus disease 2019 (COVID-19) is a new disease caused by a novel coronavirus, Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). The disease has several symptoms from mild to severe and could lead to death for comorbidities and the elderly. Therefore, the infections and mortality cases keep growing day by day, moreover many authorities are trying to suppress it by applying several health protocols, including medicines. Several studies were conducted on drug discovery from plants to cure the disease. The article aimed to do a narrative review about the prospect of JAMU becoming an alternative medicine to cure COVID-19 by mapping …

Neutralization Escape, Infectivity, And Membrane Fusion Of Jn1-Derived Sars-Cov-2 Slip, Flirt, And Kp2 Variants, Pei Li, Julia N Faraone, Cheng Chih Hsu, Michelle Chamblee, Yi-Min Zheng, Claire Carlin, Joseph S Bednash, Jeffrey C Horowitz, Rama K Mallampalli, Linda J Saif, Eugene M Oltz, Daniel Jones, Jianrong Li, Richard J Gumina, Kai Xu, Shan-Lu Liu

Faculty, Staff and Student Publications

We investigate JN.1-derived subvariants SLip, FLiRT, and KP.2 for neutralization by antibodies in vaccinated individuals, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-infected patients, or class III monoclonal antibody S309. Compared to JN.1, SLip, KP.2, and especially FLiRT exhibit increased resistance to bivalent-vaccinated and BA.2.86/JN.1-wave convalescent human sera. XBB.1.5 monovalent-vaccinated hamster sera robustly neutralize FLiRT and KP.2 but have reduced efficiency for SLip. All subvariants are resistant to S309 and show decreased infectivity, cell-cell fusion, and spike processing relative to JN.1. Modeling reveals that L455S and F456L in SLip reduce spike binding for ACE2, while R346T in FLiRT and KP.2 strengthens …

Address The Mess: The Role Of Fear Of Covid-19, Indecision, And Reactance In Decluttering Projects, Devki Patel

College of Science and Health Theses and Dissertations

At the start of the pandemic in the United States, government-imposed behavioral restrictions were enacted to reduce transmission of COVID-19. Mandated time at home motivated many to engage in organizing or decluttering projects. For some, restrictions may have increased the experience of psychological reactance, a negative motivational state evoked by a perceived threat to freedom. The proposed research studied decluttering behavior in a community-based sample, yielding insights on what influences disposal decisions in individuals who have clutter but do not consider themselves as having a hoarding problem. Three previously unexplored variables, fear of COVID-19, reactance, and family composition are considered …

The Sharp Edge Of Immunosuppressive Treatments: Infections, Aybegüm Özşahi̇n, Tuba İlgar, Sudem Mahmutoğlu Çolak, Kübra Akyüz, Meli̇h Gaffar Gözükara, Uğur Kostakoğlu, İlknur Esen Yildiz, Ayşe Ertürk

Turkish Journal of Medical Sciences

Background and aim: Different side effects, including infections, are encountered in patients receiving anticytokines used for the treatment of severe coronavirus disease 2019 (COVID-19). The aim of this study was to evaluate the infections and the effects of these infections that develop in this patient group. Materials and Methods: This study included 208 patients who were followed-up with the diagnosis of severe COVID-19 in two different hospitals. Patient data were obtained retrospectively from the hospital information system. Results: Of the 208 patients included, 54 were in the anakinra group, and 154 were in the tocilizumab group. Of these patients, 73 …

Do Patients Infected With Human Coronavirus Before The Covid-19 Pandemic Have Less Risk Of Being Infected With Covid-19?, Gamze Şanlidağ İşbi̇len, Ayça Aydin Uysal, Seli̇n Yi̇ği̇t, Özgür Appak, Hi̇lal Si̇pahi̇, Gülendam Bozdayi, Arzu Sayiner, Candan Çi̇çek, Özlem Güzel Tunçcan, Oğuz Reşat Si̇pahi̇

Turkish Journal of Medical Sciences

Background/aim: Although seasonal human coronaviruses (HCoVs) have long been recognized as respiratory tract viruses, the newly identified SARS-CoV-2 caused a pandemic associated with severe respiratory failure. We aimed to evaluate the incidence of COVID-19 infection in patients diagnosed in three tertiary teaching hospitals, both with and without prior confirmed HCoV infection, and to compare these cohorts in terms of COVID-19 contraction.Materials and methods: In our study, we examined HCoV PCR-positive cases obtained retrospectively between January 2014 and March 2020 from three University Hospital Microbiology Laboratories (Cohort 1), as well as PCR-negative patients detected in the same PCR cycle as the …

Comparison Of Bulut Index-Beta Method And Global Health Security Index: Results From World Countries, Tevfi̇k Bulut, Mehmet Top, Murat Atan, Burkay Genç

Turkish Journal of Medical Sciences

Background/aimThe Global Health Security Index (GHSI), which is used to assess global health security preparedness level of countries, and Bulut Index-Beta (BI-β) method, developed as a multi-criteria decision-making method, were compared in terms of global health security in the context of world countries. Thus, it is aimed to demonstrate feasibility of BI-β method by testing it on GHSI datasets and then to contribute to methodological development of GHSI.Materials and methodsData set of the study consists of the publicly available GHSI data set, which allows for comparative evaluation of countries. BI-β method and GHSI were used to compare countries in terms …

The Effectiveness And Safety Of Stellate Ganglion Block In The Treatment Of Symptoms From Long Covid-19: A Pilot Study, Alexa O Levey, Grant H Chen, Alexandra Ngyuen, Luis Ostrosky-Zeichner, Jamal Hasoon, Sepideh Saroukhani, Matthew Lin

Faculty, Staff and Student Publications

Purpose: Pilot study to evaluate the safety and effectiveness of stellate ganglion blocks in the treatment of symptoms related to long COVID infection.

Materials and methods: A total of 17 patients who underwent stellate ganglion block for the treatment of their long COVID symptoms were included. COMPASS-31, GAD-7, PCL-5, and Fatigue Severity Score (FSS) pre and post intervention surveys and data on baseline heartrate and post- block heart rate recorded in the EMR.

Results: A total of 94% of patients reported moderate-to-severe autonomic dysfunction pre-procedure as measured by COMPASS-31. All patients reported some degree of symptomatic improvement from the block. …

Exploring The Covid-19 Infodemic In Alaska, Emily Maxwell

Interdisciplinary Studies

The onset of the COVID-19 global health crisis coincided with an unprecedented rise in health misinformation and false narratives related to the disease. This simultaneous spread of accurate and inaccurate information, referred to as an infodemic, has had observable impacts on the trajectory of the pandemic and the future of public health. While health misinformation has been a factor in previous outbreaks, the increased prominence of social media as an information platform allowed misinformation to spread more widely and rapidly than ever before. This investigation aims to assess the impacts of COVID-19 misinformation in Alaska using a mixed methods approach. …

Impacts Of Covid-19 And Taliban Takeover On U.S. Afghan Refugee Women’S Mental Health: A Socio-Ecological Approach To Resilience Resources, Atefeh Aghaei

Theses and Dissertations

In response to the escalating global refugee crisis, intensified by ongoing conflicts and environmental changes, this dissertation research focuses on the mental health of Afghan refugee women in the United States (U.S.), particularly in the context of the COVID-19 pandemic and the 2021 Taliban takeover. With over 114 million people displaced globally, Afghan refugees, notably women, encounter heightened mental health risks due to violence, deprivation, systemic persecution, and the challenges of migration. This vulnerability is exacerbated by recent mass traumatic events, including the pandemic and political upheaval in Afghanistan. Our study, conducted through semi-structured interviews with Afghan refugee women and …

What Is The Economic Benefit Of Annual Covid-19 Vaccination From The Adult Individual Perspective?, Sarah M Bartsch, Kelly J O'Shea, Colleen Weatherwax, Ulrich Strych, Kavya Velmurugan, Danielle C John, Maria Elena Bottazzi, Mustafa Hussein, Marie F Martinez, Kevin L Chin, Allan Ciciriello, Jessie Heneghan, Alexis Dibbs, Sheryl A Scannell, Peter J Hotez, Bruce Y Lee

Center for Medical Ethics and Health Policy Staff Publications

Background: With coronavirus disease 2019 (COVID-19) vaccination no longer mandated by many businesses/organizations, it is now up to individuals to decide whether to get any new boosters/updated vaccines going forward.

Methods: We developed a Markov model representing the potential clinical/economic outcomes from an individual perspective in the United States of getting versus not getting an annual COVID-19 vaccine.

Results: For an 18-49 year old, getting vaccinated at its current price ($60) can save the individual on average $30-$603 if the individual is uninsured and $4-$437 if the individual has private insurance, as long as the starting vaccine efficacy against severe …

Pre-Existing Immunocompromising Conditions And Outcomes Of Acute Covid-19 Patients Admitted For Pediatric Intensive Care, Courtney M Rowan, Brenna Labere, Cameron C Young, Laura D Zambrano, Margaret M Newhams, Suden Kucukak, Elizabeth R Mcnamara, Elizabeth H Mack, Julie C Fitzgerald, Katherine Irby, Aline B Maddux, Jennifer E Schuster, Michele Kong, Heda Dapul, Stephanie P Schwartz, Melania M Bembea, Laura L Loftis, Amanda R Kolmar, Christopher J Babbitt, Ryan A Nofziger, Mark W Hall, Shira J Gertz, Natalie Z Cvijanovich, Matt S Zinter, Natasha B Halasa, Tamara T Bradford, Gwenn E Mclaughlin, Aalok R Singh, Charlotte V Hobbs, Kari Wellnitz, Mary A Staat, Bria M Coates, Hillary R Crandall, Mia Maamari, Kevin M Havlin, Adam J Schwarz, Christopher L Carroll, Emily R Levy, Kristin L Moffitt, Angela P Campbell, Adrienne G Randolph, Janet Chou

Faculty, Staff and Students Publications

BACKGROUND: We aimed to determine if pre-existing immunocompromising conditions (ICCs) were associated with the presentation or outcome of patients with acute coronavirus disease 2019 (COVID-19) admitted for pediatric intensive care.

METHODS: Fifty-five hospitals in 30 US states reported cases through the Overcoming COVID-19 public health surveillance registry. Patients(PICU) or high-acuity unit for acute COVID-19 were included.

RESULTS: Of 1274 patients, 105 (8.2%) had an ICC, including 33 (31.4%) hematologic malignancies, 24 (22.9%) primary immunodeficiencies and disorders of hematopoietic cells, 19 (18.1%) nonmalignant organ failure with solid-organ transplantation, 16 (15.2%) solid tumors, and 13 (12.4%) autoimmune disorders. Patients with ICCs were …

Equity-Informed Social Media Covid-19 Risk Communication Strategies: A Scoping Review, Nedra Peter, Lorie Donelle Phd, Rn, Fcan, Catherine George, Anita Kothari

Publications

OBJECTIVES: The COVID-19 pandemic has had devastating worldwide impact but most prominent was its effect on marginalised, underserved and equity-deserving populations. Social media arose as an important platform from which health organisations could rapidly disseminate information to equity-deserving populations about COVID-19 risks and events, provide instructions on how to mitigate those risks, motivate compliance with health directives, address false information, provide the opportunity for engagement and immediate feedback. The objective of this scoping review was to synthesise the academic and grey literature on equity-informed social media risk communication strategies developed during the pandemic. DESIGN: The review followed the Arksey and …

The Experience Of Middle School Special Education Teachers In New Jersey Teaching Virtually During Covid-19, Yolanda Henderson

Doctoral Dissertations and Projects

The purpose of this transcendental phenomenological study is to describe the experiences of middle school special education teachers working remotely in New Jersey during the COVID-19 pandemic. The conceptual framework that guided this study was Schlossberg’s Transition Theory. Schlossberg's Transition Theory refers to events that result in a change of relationships, routines, assumptions, or roles. This theory allowed me to see the various phases such as moving in, through, and out of the COVID-19 pandemic. Recognizing how the pandemic affected the relationships, routines, and roles of teachers made it easy to understand how this theory related directly to the pandemic. …

Safety And Feasibility Of Third-Party Cytotoxic T Lymphocytes For High-Risk Patients With Covid-19, Dolores Grosso, John L. Wagner, Allyson O'Connor, Kaitlyn Keck, Yanping Huang, Zi-Xuan Wang, Hilary Mehler, Benjamin Leiby, Phyllis Flomenberg, Usama Gergis, Neda Nikbakht, Michael Morris, Julie Karp, Alexis R. Peedin, Neal Flomenberg

COVID-19 Papers, Posters, and Presentations

Cytotoxic T lymphocytes (CTLs) destroy virally infected cells and are critical for the elimination of viral infections such as those caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Delayed and dysfunctional adaptive immune responses to SARS-CoV-2 are associated with poor outcomes. Treatment with allogeneic SARS-CoV-2-specific CTLs may enhance cellular immunity in high-risk patients providing a safe, direct mechanism of treatment. Thirty high-risk ambulatory patients with COVID-19 were enrolled in a phase 1 trial assessing the safety of third party, SARS-CoV-2-specific CTLs. Twelve interventional patients, 6 of whom were immunocompromised, matched the HLA-A∗02:01 restriction of the CTLs and received …

Women's Experience Of Cancer Treatment During Covid-19 On The Texas-Mexico Border, Kayla E. Castañeda

Nursing Theses and Dissertations

The COVID-19 pandemic exposed existing racial, ethnic, socioeconomic, geographic, and gender disparities in cancer care and highlighted the need for more research in understudied populations. No studies have elucidated the experience of women living on the Texas-Mexico border receiving cancer treatment during the pandemic. This study explored the lived experience of receiving cancer treatment during the COVID-19 pandemic in 2020 for women living on the Texas-Mexico border and identified participants' self-identified unmet needs while receiving cancer treatment during the COVID-19 pandemic on the Texas-Mexico border. Following IRB approval and informed consent, ten women living on the Texas-Mexico border who received …