Digital Commons Network^™

Early Taurine Administration As A Means For Halting The Cytokine Storm Progression In Covid-19 Patients, Alberto Rubio-Casillas, Ramesh C. Gupta, Elrashdy M. Redwan, Vladimir N. Uversky, Raied A. Badierah

Molecular Medicine Faculty Publications

Around the world, more than 6.2 million individuals have died as a result of coronavirus disease 2019 (COVID-19). According to a recent survey conducted among immunologists, epidemiologists, and virologists, this disease is expected to become endemic. This implies that the disease could have a continuous presence and/or normal frequency in the population. Pharmacological interventions to prevent infection, as well as to treat the patients at an early phase of illness to avoid hospitalization are essential additions to the vaccines. Taurine is known to inhibit the generation of all inflammatory mediators linked to the cytokine storm. It can also protect against …

Synthesis, Characterization, Computational Analyses, In Silico Admet Studies, And Inhibitory Action Against Sars-Cov-2 Main Protease (Mpro) Of A Schiff Base, Songül Şahi̇n, Necmi̇ Dege

Turkish Journal of Chemistry

COVID-19 disease caused by the severe acute respiratory syndrome coronavirus (SARS-CoV-2) has struck the whole world and raised severe health, economic, and social problems. Many scientists struggled to find a vaccine or an antiviral drug. Eventually, both vaccines and recommended drugs, repurposed drugs, or drug combinations were found, but new strains of SARS-CoV-2 continue to threaten human life and health. As part of the fight against COVID-19 disease, this study involves an in silico molecular docking analysis on the main protease (Mpro) of SARS-CoV-2. To this aim, a Schiff base compound was synthesized and characterized using spectroscopic techniques, including X-ray, …

Botanicals As Prospective Agents Against Sars-Cov-2 Virus, Vyacheslav Dushenkov, Anna Dushenkov

Publications and Research

The COVID-19 high morbidity and mortality resulted in a worldwide healthcare emergency that triggered accelerated and amplified efforts in the relevant areas of health sciences research and practice. Purpose: To assess the potential role of botanicals as therapeutic agents against the SARS-CoV-2 virus. Methods: This narrative review examined the potential role of botanicals as therapeutic agents against the SARS-CoV-2 virus based on the references limited to the English language and published up to February 2022 and retrieved from common academic search engines using multiple keywords and their combinations. The scientific names of plant species were confirmed using World Flora Online …

Our Thoughts Matter: The Mental Health Of College Students During The Covid-19 Pandemic, Caitlin Zarzeczny

UNF Graduate Theses and Dissertations

This study aimed to explore the mental health of undergraduate college students within the context of COVID-19 pandemic, as well as cognitions about health threat and engagement in protective health behaviors during the COVID-19 pandemic. Participants were (N = 276) undergraduate students attending the University of North Florida. Students completed a SONA systems survey between March 2021 and December 2021. Participants received course credit for completing the survey. Survey questions were taken from the Perceived Effectiveness of COVID-19 Prevention Effectiveness Protocols scale (Prasetyo et al., 2020). Three types of variables were assessed: demographics, perceived threat, and planned action. Correlational …

Social Determinants Of Disease: Hiv And Covid-19 Experiences, Raiza M. Beltran, Ian W. Holloway, Chenglin Hong, Ayako Miyashita, Luisita Cordero, Elizabeth Wu, Katherine Burris, Paula M. Frew

Epidemiology & Biostatistics Faculty Research

Purpose of Review: The differential impact of the COVID-19 and HIV pandemics on marginalized communities has renewed calls for more robust and deeper investigation into structural and social causes of health inequities contributing to these infections, including underlying factors related to systematic racism. Using the Social Determinants of Health (SDOH) framework, we analyzed parallel and divergent factors associated with COVID-19 and HIV/AIDS and the prevalence of disparate disease in diverse communities. We utilized PRISMA guidelines to identify relevant literature (N = 210 articles) that resulted in a review of 125 articles included in our synthesis. Recent Findings: With racial health …

The Role Of Response Efficacy And Risk Aversion In Promoting Compliance During Crisis, Veronica L. Thomas, Hooman Mirahmad, Grace Kemper

Marketing Faculty Publications

This research examines consumers' compliance with behaviors that focus on preventing the spread of COVID‐19. Drawing on Protection Motivation Theory and research on efficacy, we find that, during a pandemic, consumers who have higher perceptions of response efficacy are less likely to engage in risky consumption behaviors (Study 1) and more likely to engage in protective consumption behaviors (Study 2). This effect is moderated by risk aversion, such that as risk aversion increases, COVID‐compliant behaviors increase even when consumers do not believe in their ability to effectuate change. Further, the relationship between response efficacy and COVID‐compliant behaviors is mediated by …

Investigating Public Support For Biosecurity Measures To Mitigate Pathogen Transmission Through The Herpetological Trade, Elizabeth F. Pienaar, Diane J. Episcopio-Sturgeon, Zachary T. Steele

Biological Sciences Faculty Publications

The expanding global trade in herpetofauna has contributed to new infectious disease dynamics and pathways that allow for the rapid spread of pathogens geographically. Improved biosecurity is needed to mitigate adverse biodiversity, economic and human health impacts associated with pathogen transmission through the herpetological trade. However, general lack of knowledge of the pathogen transmission risks associated with the global trade in herpetofauna and public opposition to biosecurity measures are critical obstacles to successfully preventing pathogen transmission. In 2019 we administered a survey to 2,007 members of the public in the United States of America to ascertain their support for interventions …

No-Fault Vaccine Injury Compensation Systems Adopted Pursuant To The Covid-19 Public Health Emergency Response, Sam Halabi, Katherine Ginsbach, Katie Gottschalk, John Monahan, Judith Murungi

Emory International Law Review

No-fault vaccine injury compensation systems have developed over the course of the twentieth century, mostly in the richest countries in the world. Acknowledging that severe reactions to vaccines are rare, but can result in serious and sometimes complex injury, these systems provide financial and social support for those suffering these rare side effects. During the COVID-19 pandemic, and the rapid development and deployment of vaccines using novel technologies, these systems have proliferated not only among wealthy countries, where in their modern form they originated and spread, but also low- and middle-income ones. Adopting varying approaches to funding, eligibility, administration, process, …

Remdesivir Treatment For Patients With Moderate To Severe Covid-19, İmran Hasanoğlu, Hati̇ce Rahmet Güner, İlhami̇ Çeli̇k, Fi̇kret Kanat, Ayşe Batirel, Gülçi̇n Telli̇ Di̇zman, Esma Eryilmaz Eren, Di̇lek Yildiz Sevgi̇, İlkay Bozkurt, Kadri̇ye Kart Yaşar, Sevtap Şenoğlu, Esra Kazak, Ridvan Karaali̇, Aysel Kocagül Çeli̇kbaş, Hüsnü Pullukçu

Turkish Journal of Medical Sciences

Background/aim: Remdesivir, which was first developed for the treatment of Ebola disease but failed to meet expectations, has become hope in the fight against the COVID-19 pandemic. This study aimed to evaluate risk factors for mortality and prognosis of adult moderate/severe COVID-19 patients treated with remdesivir, and safety and tolerability of 5 days of remdesivir treatment. Materials and methods: This multicenter prospective observational study was conducted in 14 centers in Turkey. Pregnancy or breastfeeding, multiorgan failure, or usage of vasopressors for septic shock, ALT > 5 × the upper limit of the normal range, or eGRF

Covid-19, Chronic Stress, And Adolescent Mental Health, Corina Barker

DSW Capstone Projects

The COVID-19 pandemic has had an undeniable impact on adolescent mental health. Though not considered to be high risk when it comes to physically contracting the virus itself, adolescents have shown to be significantly impacted by the indirect effects of the pandemic. Because of the unique and formative time, this is in their lives, adolescents are already vulnerable to the impact of social stressors. Risk factors associated with the COVID-19 pandemic such as social isolation, disruption in routine, uncertainty, fear, and chronic stress have all proven to have a profound negative impact on adolescent mental health and overall well-being. It …

Nutritional Status In Critical Care Of Covid-19 Patients, Dolph Lewis Davis Iii

Theses and Dissertations--Nutrition and Food Systems

Critical care nutrition is a poorly researched, and such a sudden pandemic event requiring manipulation of nutritional status via propofol-induced sedation for mechanical ventilation is potentially impactful on patient outcomes. This paper seeks to provide context to the impact of critical care protocols on the nutritional status of obese patients suffering from COVID-19.

Anthropological Responses To Covid-19 In The Philippines, Gideon Lasco

Development Studies Faculty Publications

This article reflects on the roles anthropologists have played in responding to the COVID-19 pandemic in the Philippines, and identifies the challenges – from the methodological to the political – they faced in fulfilling these roles. Drawing on the author's personal and professional experiences in the country, as well as on interviews with other anthropologists, this article identifies three major roles for anthropologists: conducting ethnographic research; bearing witness to the pandemic through first-person accounts; and engaging various publics. All these activities have contributed to a greater recognition of the role of the social sciences in health crises, even as anthropologists …

‘Loob’ And ‘Labas’: Spatial Constructions Of Safety And Risk Amid The Covid-19 Pandemic In The Philippines, Gideon Lasco, Michael L. Tan, Vincen Gregory Yu

Development Studies Faculty Publications

This article argues that local constructions of risky and safe spaces, as articulated by the notions ‘loob’ (inside) and ‘labas’ (outside), informed popular and political responses to the COVID-19 pandemic in the Philippines, leading to an overemphasis on staying at home and, conversely, a general avoidance or fear of outdoor spaces that was at times reinforced by public health authorities. Practices and policies related to the pandemic response rendered this binary opposition between ‘loob’ and ‘labas’ visible, from regulations concerning the use of personal protective equipment to restrictions of access to outdoor spaces. While this emergent …

An Agent-Centered Approach To Covid-19 Vaccinations, Nila Venkat

CMC Senior Theses

The rise of COVID-19 has dramatically affected the global economy, healthcare systems, and individuals’ daily lives. One of the most controversial attempts to ameliorate the effects of the virus in the United States has been the distribution of COVID-19 vaccinations. In this thesis, I propose a novel agent-centered approach to motivating COVID-19 vaccinations. I begin by exploring the origins and evolution of the virus, along with the growing demographic of “vaccine-hesitant” Americans, to contextualize the debate surrounding vaccinations. I then propose two potential action-based response strategies for vaccine motivation: a vaccine mandate and nudges. Concerning a mandate response strategy, I …

The Influence Of Political Party Affiliation And Park Accessibility On Covid-19 Case Incidence, Sascha Wolf-Sorokin

CMC Senior Theses

This paper examines the joint effect of political party affiliation and the urban landscape, as measured by access to parks, on case rates during the COVID-19 pandemic in the United States. The 2016 and 2020 U.S. Presidential Election returns are used as a proxy for a county’s political party affiliation prior to and during the COVID-19 pandemic. A county population’s spatial relationship to its parks encapsulates the green open space within an urban environment. The data set controls for features of the built environment, socioeconomic and demographic characteristics (race, gender, income, education), COVID-19 government regulations, and presidential election returns. Using …

Reddit As A Source Of Covid-19 Information: A Content Analysis Of R/Coronavirus During The Early Pandemic, Brent Hale, Mark Alberta, Seung Woo Chae

Faculty Publications

Emerging research has begun examining the utility of social media platforms for information dissemination during the COVID-19 pandemic. Following this developing thread, this work examines discourse within r/coronavirus, a Reddit forum (i.e., subreddit) developed to curate COVID-19 information that burgeoned during the early months of the pandemic. Through a content analysis of 226 posts and 2260 corresponding comments generated between February and May, 2020, this study investigated early-pandemic communication patterns in this platform, including what information was deemed important and how users framed causes and solutions. Overall, findings indicate that users of r/coronavirus prioritized information about COVID-19 spread, public health …

Bodily Autonomy And Anti-Vaccine Discourse During The Covid-19 Pandemic, Haley Sherman

Capstone Showcase

This paper explores the relationship between anti-vaccine discourse and ideas about bodily autonomy. I analyze the cyclical nature of vaccine hesitancy and show that it can lead to misinformation and harmful narratives. This paper uses theories of bodily autonomy that identify a concept called moral obligation. This concept, as explored by Alberto Giubilini, is a utilitarian approach in which citizens have a responsibility to their governments to get vaccinated so that, in turn, their governments can fulfill their obligation of protecting other individuals’ health (Giubilini 2020, 54). A discourse analysis of four key players in the anti-vax movement shows that …

Does The Novel Coronavirus Use The Ocular Surface As An Entrance Into The Body Or As An Infection Site?, Remzi Karadag, Alp Kayiran, Christopher J Rapuano

Wills Eye Hospital Papers

This study attempts to review whether the coronavirus disease-2019 (COVID-19) is transmitted through the ocular surface and examine the symptoms and signs of ocular disease. Considering that COVID-19 is transmitted by airborne droplets and close contact with infected individuals, we will also review the conditions to which eye clinics and ophthalmologists should pay attention to prevent the transmission of the disease. Although some researchers have argued that COVID-19 transmission cannot occur through the ocular surface, most of them are of the opinion that the ocular surface is a potential pathway of transmission. Until date, ocular signs and symptoms have been …

Modelling Pretrial Detention, Melissa Hamilton

American University Law Review

Pretrial detention has become normative in contemporary criminal justice, rather than the exception to a rule of release for individuals not convicted of any crime. Even the opportunity for release with a bond amount often eludes the many individuals who are unable to afford, to pay. Defendants detained, pending trial suffer numerous negative consequences to their own legal cases, such as being more likely to feel pressured to plead guilty and to receive a prison sentence. The high numbers of those detained appear to disproportionately impact minorities and. have contributed to mass incarceration. As a. result, of these issues, the …

Shift In Education: The Impact Of Covid-19 On Face-To-Face And Virtual Learning, Donya Jones

Doctor of Education Dissertations

This qualitative study was conducted to investigate the impact COVID-19 had on teachers’ instructional practices, technology preparedness, and social and emotional well-being. The results of this study can be used to inform school leaders, administrators, and teachers about methods to support teachers who teach during a worldwide crisis. The study was conducted utilizing a survey instrument and interviews. The survey and interviews indicated that COVID-19 affected teachers who taught virtually during the COVID-19 pandemic. The survey and interview participants identified supports that teachers needed to have in order to successfully teach virtually during a pandemic, such as technology, professional development …

Outcomes Of Surgical Tracheostomy On Mechanically Ventilated Covid-19 Patients Admitted To A Private Tertiary Hospital In Tanzania, Nadeem Kassam, Ally Zain, Sajida Panjwani, Kamran Hameed, Samina Somji, Hanifa Mbithe, Fatma Bakshi, Bonvetura Mtega, Gloria Kinasa, Blessing Mathew, Harrison Chuwa

Internal Medicine, East Africa

Objectives: The coronavirus disease 2019 (COVID-19) pandemic has resulted in an increase in the number of patients necessitating prolonged mechanical ventilation. Data on patients with COVID-19 undergoing tracheostomy indicating timing and outcomes are very limited. Our study illustrates outcomes for surgical tracheotomies performed on COVID-19 patients in Tanzania.

Methods: This was a retrospective observational study conducted at the Aga Khan Hospital in Dar es Salaam, Tanzania.

Results: Nineteen patients with COVID-19 underwent surgical tracheotomy between 16 th March and 31st December 2021. All surgical tracheostomies were performed in the operating theatre. The average duration of intubation prior to tracheotomy …

A Proportionality-Based Framework For Government Regulation Of Digital Tracing Apps In Times Of Emergency, Sharon Bassan

Dickinson Law Review (2017-Present)

Times of emergency present an inherent conflict between the public interest and the preservation of individual rights. Such times require granting emergency powers to the government on behalf of the public interest and relaxing safeguards against government actions that infringe rights. The lack of theoretical framework to assess governmental decisions in times of emergency leads to a polarized and politicized discourse about potential policies, and often, to public distrust and lack of compliance.

Such a discourse was evident regarding Digital Tracing Apps (“DTAs”), which are apps installed on cellular phones to alert users that they were exposed to people who …

Investigating The Main Protease (Mpro) Of Sars-Cov-2 As A Potential Drug Target, Valerie Giovina Pascetta

Honors Theses and Capstones

The rapid spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of the coronavirus disease 19 (COVID-19) pandemic has claimed the lives of roughly 6.2 million people worldwide as of May 2022. The virus’s main protease (M^pro ) has been identified as an attractive drug target due to the critical role it plays in the viral life cycle. The roughly 34 kDa M^pro cleaves functional viral polypeptides out of two long polyproteins at conserved cut sites, allowing them to fulfill their role in processes like transcription and replication. Here, we have studied the enzymatic activity …

The Case Of Singapore, Hwee Kwan Chow, Kong Weng Ho

Research Collection School of Economics

The economic impact of the Covid-19 pandemic on Singapore was more severe and protracted than the global financial crisis. Singapore responded with easing of the monetary policy stance, reinforcing financial stability, helping individuals to reduce debt obligations, easing business cashflow constraints, adjusting financial regulatory and supervisory protocols to cope with immediate challenges, and enabling the financial sectors to build long-term capabilities. Fiscal responses were unprecedented with four consecutive budgets and two ministerial statements, initially focusing on immediate assistance in respect of jobs, businesses, households, and later refined to providing more sector-specific assistance as the pandemic evolved with more detailed information …

Public Policy (Not The Coronavirus) Should Shape What Endemic Means, Ronald U. Mendoza, Kenneth Hartigan-Go, Alex B. Brillantes, Karl Ev Ruiz, Ivyrose S. Baysic, Sheena A. Valenzuela

Ateneo School of Government Publications

Endemicity is not only a biological and health event but has several inter-dependencies cross-cutting with the management of the economy, including governance and policies. Within the context of the discourse on inequity, what does endemicity mean for poor and low-income families, where policies on social inclusion and social welfare need to be re-calibrated?

What Should Ethical And Strategic Employers Do About Covid-19 Vaccines?, Dale B. Thompson, Susan A. Suspina, Katherina G. Pattit, Dawn R. Swink

University of San Francisco Law Review

No abstract provided.

Adoptive T-Cell Therapies To Overcome T Cell-Dependent Immune Dysregulations In Covid-19, Sevgi̇ Kalkanli Taş, Merve Sai̇de Uzunoğlu, Ayli̇n Seher Uzunoğlu, Duygu Kirkik, Derya Altunkanat, Nevi̇n Kalkanli

Turkish Journal of Biology

Coronavirus disease 2019 (COVID-19) pandemic has been an important global interest that affected millions of people, and it requires a deep investigation of the disease immunology for developing further therapeutic applications. Adoptive T cell therapy promises to address T cell-dependent immune dysregulation in COVID-19 patients by the generation of specific T cell clones against virus-specific antigens. Additionally, targeting B cell-dependent protection through COVID-19 vaccines, which have been developed in the recent year, possessed sufficient prevention for spreading the virus, since the cases and deaths related to COVID-19 tend to decrease after the vaccination. However, adoptive cell therapies are now encouraging …

Development A Novel Multi-Epitope Dna Vaccine Against Human Sars Coronavirus-2: An Immunoinformatics Designing Study, Afshin Samimi Nemati, Sako Mirzaie, Mohammad Reza Masoumian, Fatemeh Sheikhi, Mostafa Jamalan

Turkish Journal of Biology

Human SARS coronavirus 2 (SARS-CoV-2) causes the current global COVID-19 pandemic. The production of an efficient vaccine against COVID-19 is under heavy investigation. In this study, we have designed a novel multiepitope DNA vaccine against SARS-CoV-2 using reverse vaccinology and DNA vaccine approaches. Applying these strategies led to reduce the time and costs of vaccine development and also improve the immune protective characteristics of the vaccine. For this purpose, epitopes of nucleocapsid, membrane glycoprotein, and ORF8 proteins of SARS-CoV-2 chose as targets for B and T-cell receptors. Accordingly, DNA sequences of selected epitopes have optimized for protein expression in the …

Themes And Associations Concerning The Covid-19 Pandemic: Autoethnography, Amber Mcgannon, Ebunoluwa O. Adedeji

Williams Honors College, Honors Research Projects

Per the college of nursing, my proposed project will discuss living during uncertain times and unusual times of change. This APA formatted paper will be an autoethnography, meaning that we will review the perspectives of COVID through the lens of culture, research, and our own perspectives and experiences. Everyone has experienced changes during the COVID-19 pandemic due to self-isolation. Examples of change include changes in learning, working, thinking, teaching, and behaving. Using acquired nursing skills such as critical thinking, reflection, inquiry, and evidenced-based practice; my partner and I will dissect and discuss these changes and how they have affected ourselves, …

Auto- Ethnography With A Deep Dive Into Changes Mental Health During The Pandemic And A Look Into The Way The Pandemic Has Shaped Nursing Protocols For Recent Nursing College Graduates, Audrey Shaffer, Sarah Bereznay

Williams Honors College, Honors Research Projects

In this project we completed a deep dive into how the Covid-19 pandemic reshaped our mental health and has affected our preparation for careers as registered nurses through a series of auto- ethnographic narrative journals using scholarly articles to support this idea. By utilizing personal narratives, we analyzed and reflected upon the cognitive and mental changes we experienced throughout this pandemic. We fulfilled this by comprising two personal narratives with inquiries pertaining to each shared narrative by utilizing the common themes of being nursing students and living through a pandemic. Within these personal narratives, we discussed how the pandemic influenced …