Digital Commons Network^™

The Impact Of Covid-19 On Higher Education Enrollment, Samuel Tanner Mcknight

Student Theses and Dissertations

Impacts to postsecondary institutions’ enrollment and financial positions that resulted from the COVID-19 pandemic were examined in this study. Taking a quantitative observational approach, enrollment trends as they relate to changes in tuition and fee revenue, unrestricted cash on hand, and unrestricted investments held are analyzed to determine the extent of exposure faced by postsecondary institutions caused by the COVID-19 pandemic. Using the results from this statistical analysis, the need for postsecondary institutions to maintain financial contingency funds in the form of liquid reserves are highlighted and emphasized through the lens of Bowen’s revenue theory of cost. The majority of …

Examining The Influence Of Students’ Mental Health Problems On Their Social And Emotional Health: Perspectives Of Counselors And Mental Health Therapists In A Post-Pandemic World, Brandi Leigh Newsom

Student Theses and Dissertations

Examining the Influence of Students’ Mental Health Problems on Their Social and Emotional Health: Perspectives of Counselors and Mental Health Therapists in a Post-Pandemic World This qualitative phenomenological study explored the influence mental health issues have on social emotional learning in the public-school setting. The problem addressed in this study was the increased need for mental health resources and awareness in the school setting. By assessing the perspectives of school counselors and mental health therapists, awareness and resources can help students who are struggling with social-emotional needs. The guiding theoretical framework that served as the basis for this study was …

Teacher Perceptions Of Reading And Mathematics Achievement Gaps Among Elementary Students Resulting From The Covid-19 Pandemic, Kayla Lynn Caprio

Student Theses and Dissertations

The purpose of this descriptive qualitative case study was to discover Second through Fifth Grade rural North Texas teacher perceptions focusing on reading and mathematics student achievement gaps resulting from the COVID-19 pandemic. This study explores how the COVID-19 pandemic shutdown affected students not only academically but also socially as well. Through a qualitative case study design, this study collected qualitative data by interviewing seven-Second through Fifth Grade teachers through semi-structured interviews, a focus group, and MAP data by analyzing MAP data collected in the beginning and middle of the year from the 2019-2023 school years. The social learning theory …

Design Thinking Strategies For Complex Situations: Covid-19 In Western Australia And New South Wales, Terence Love, Paul Cozens, Trudi Cooper

Research outputs 2022 to 2026

This paper outlines an argument for changing the foundation of design thinking practices to include causal feedback loops instead of primarily predicting futures using linear causal relations. The paper suggests for most real-world design situations the traditional linear causal perspective is insufficient and leads to lower value design outcomes. The authors propose instead designers address real-world complex design situations via design methods that include feedback loops, which require different design methods and tools. The discussion in the paper follows the understanding of systems researchers. The authors provide an example of the significant differences in outcomes using a comparative case study …

A Case Study: Do You Address Your Volunteers’ Well-Being Or Mental Health During The Covid-19 Pandemic? If So, How?, Daniel J. Robotham, Suzanna R. Windon, Ann E. Echols

Journal of Extension

The uncertainty caused by the COVID-19 pandemic had a profound negative impact on volunteer mental health and well-being. We surveyed local non-profit organizational leaders about their practices toward addressing volunteer well-being and mental health during the COVID-19 pandemic. Study results indicated that while over a quarter of organizations did nothing to address volunteer well-being, other organizations utilized several approaches, including one-on-one and group meetings, program implementation, office culture investment, task assignment, and information dissemination. These findings provide valuable insight for Extension educators to develop community mental health and well-being programs to assist non-profit organizations' response to future uncertainty.

Applying A Framework Of Epistemic Injustice To Understand The Impact Of Covid-19 On People With Intellectual And Developmental Disabilities, Sarah Lineberry, Matthew Bogenschutz

Developmental Disabilities Network Journal

Epistemic injustice, the theory of unfairness related to knowledge, is a useful framework for understanding the ways in which historic and ongoing marginalization and stereotypes have shaped the ways that people with intellectual and developmental disabilities (IDD) have been impacted by the COVID-19 pandemic. We conducted a scoping review of the literature and divided findings into physical health (cases, hospitalization, and death) and psychosocial outcomes (access to services, mental health symptoms, community participation, etc.). Impacts were then analyzed using the key principles of epistemic injustice. Findings suggest that people with intellectual and developmental disabilities (IDD) experienced high rates of negative …

News Frames For Covid-19 – A Comparison Of Australian (Australian Broadcasting Corporation) And Vietnamese (Tuoi Tre Online) Online News Services In Two Key Weeks In 2020, Viet T. Le, Lelia Green

Research outputs 2022 to 2026

This article investigates the differences and similarities between the news frames used by online mainstream media in Vietnam and Australia when reporting COVID-19 in the early waves of the pandemic. The project uses constant comparative analysis to interrogate data gathered from two online news sources: ABC Online (Australian Broadcasting Corporation) in Australia, and Tuoi Tre Online in Vietnam. The article concludes that the Australian Broadcasting Corporation coverage focuses more on social, political and economic factors than is the case with Tuoi Tre Online, which foregrounds civic responsibility in response to the COVID-19 epidemic. The Australian Broadcasting Corporation highlights how COVID-19 …

Cystic Fibrosis-Related Diabetes Screening At A Large Pediatric Center, Anil K Chokkalla, Pamela Tuley, Miray Kurtca, Herda Ona, Fadel E Ruiz, Sridevi Devaraj

Faculty, Staff and Students Publications

Objective: Cystic Fibrosis Foundation guidelines recommend annual diabetes screening by oral glucose tolerance test (OGTT) in pediatric patients with cystic fibrosis (CF) starting at the age of 10 years. Adherence to these guidelines proves to be challenging, and the nationwide screening rates are still considered suboptimal. The aim of this study was to assess and improve the screening rates at our large pediatric center.

Methods: A 4-year retrospective audit of OGTT completion among pediatric patients with CF of age ≥10 years who are not yet diagnosed with diabetes was conducted. A collaborative working group was formed to identify the barriers …

A Survey Of Early-Career Speech-Language Pathologists: Determining Perceived Readiness For Clinical Management Of Adults With Dysphagia After Completing Graduate School, Christine A. Lee, Ashwini Namasivayam-Macdonald, Zuleikha Wadhwaniya, Juliana Mclaren, Rebecca H. Affoo

Teaching and Learning in Communication Sciences & Disorders

Several studies have identified a recurring trend that speech-language pathologists (S-LPs) in countries such as the United States (Caesar & Kitila, 2020), South Africa (Singh et al., 2015), and Malaysia (Kamal et al., 2012) report lower levels of confidence in dysphagia management, whether in comparison to other practice areas or in certain skill areas within the specialty of dysphagia. No data currently exists exploring self-perceptions of Canadian S-LP graduates with regards to clinical management of adults with dysphagia. Therefore, the purpose of this study was to determine the self-reported readiness of recently graduated Canadian S-LPs who manage dysphagia. Our survey …

The Il-6 Hypothesis In Covid-19: A Phase 2, Randomised, Double-Blind, Placebo-Controlled Study To Evaluate The Efficacy And Safety Of Free Il-6 Sequestration By The Monoclonal Antibody Sirukumab In Severe And Critical Covid-19, Robert L. Gottlieb, Meredith Clement, Paul Cook, Audra Deveikis, Kap Sum Foong, Philip Robinson, Jihad Slim, Cedric W. Spak, Annemie Buelens, Katleen Callewaert, Sandra De Meyer, Wai Ling Mo, Inge Verbrugge, Liesbeth Van Wesenbeeck, Yanli Zhuang, Jason W. Chien, Magda Opsomer, Erika Van Landuyt

School of Medicine Faculty Publications

Background: Upregulation of IL-6 has been associated with worse prognosis in COVID-19 patients. Impact on IL-6 signalling has mostly been limited to clinical outcomes in IL-6 receptor antagonist trials. Methods: We performed a phase 2, randomised, double-blind, placebo-controlled trial (NCT04380961) of US-based hospitalised adults (< 85 years) with laboratory-confirmed SARS-CoV-2 infection and severe (low levels of supplemental oxygen) or critical disease (high levels of oxygen supplementation). Patients received sirukumab 5 mg/kg or placebo single dose IV on Day 1 plus standard of care. The primary endpoint was time to sustained clinical improvement up to Day 28 based on an ordinal scale. Secondary endpoints included clinical improvement, all-cause mortality, and safety. Following an interim analysis, the protocol was amended to only recruit patients with critical COVID-19. Findings: From May 2020 to March 2021, 209 patients were randomised; 112 had critical disease (72 sirukumab, 40 placebo) at baseline. Median time to sustained clinical improvement in critical patients was 17 and 23 days in the sirukumab and placebo groups (HR, 1∙1; 95% CI, 0∙66–1∙88; p > 0∙05). At Day 28, 59∙4% versus 55∙0% of patients achieved clinical improvement with sirukumab versus placebo and rates of all-cause mortality were 24∙6% versus 30∙0%, respectively. Rates of grade ≥ 3 adverse events were comparable between the sirukumab and placebo groups (25∙9% vs 32∙9%; all patients). Interpretation: In critical COVID-19 patients who received sirukumab, there …

A Comparative Study Of Indonesia And Malaysia's Economic Resilience In The Covid-19 Era: An Analysis Of Economic Stability, Muhammad Nur Abdul Latif Nur Latif Al Waroi

Jurnal Kajian Stratejik Ketahanan Nasional

This study analyzes the economic resilience of Indonesia and Malaysia during the COVID-19 pandemic, focusing on economic stability. The research explores pre-pandemic economic conditions, the impact of COVID-19 on GDP, inflation, unemployment, and government debt, as well as recovery efforts through fiscal and monetary policies. Data from Statistics Indonesia, Department of Statistics Malaysia, World Bank, and IMF were used. Results indicate that Indonesia experienced a faster economic recovery, with GDP growth returning to pre-pandemic levels quicker than Malaysia. The economic impact of the pandemic in Indonesia is lower, supported by the National Economic Recovery Program (PEN) and Bank Indonesia's monetary …

Covid-19 Implications On Worksite Wellness Programming, Renee A. Underwood, Angela R. Wood, Ralph J. Wood, Rylie B. Broussard, Stephanie T. Broyles

Population and Public Health Science Faculty Publications

Seven of the top ten leading causes of death in the United States are due to chronic diseases and treating these accounts for 86 percent of our nation's health care costs. The workplace offers an environment to implement chronic disease prevention strategies, such as worksite wellness programs, due to the large amount of time spent at the worksite daily by employees. As a result of COVID-19, many organizations began to change their workdays (i.e., working from home). This research sought to understand what, if any, implications the COVID-19 epidemic had on worksite wellness programming. Semistructured interviews were employed and recorded …

Intimate Partner Violence And Negotiation During Covid-19: Stressors, Resources, And Perception, Victoria P. Diamond

Dissertations, Theses, and Capstone Projects

Intimate partner violence (IPV) is a serious public health concern that affects millions across the globe. The COVID-19 pandemic created unforeseen stress, and necessitated safety policies that required social isolation, often extended exposure to one’s intimate partner, and an inability to access stress-reduction resources. These factors, along with many others, lead to an abrupt increase in IPV in many couples. Using the couple-adapted family stress model (ABCX), the current study examines both previously defined (e.g., emotional dysregulation, stress, unemployment, communication issues) and COVID-19 specific risk (e.g., quarantine, unprecedented social isolation, fear of contracting COVID-19) and protective factors (e.g., meaning in …

Trends In The Incidence Of Hypertensive Disorders Of Pregnancy Among The Medicaid Population Before And During Covid-19, Jessica Lin, Heidi Feng, Ronald Horswell, San Chu, Yun Shen, Gang Hu

Population and Public Health Science Faculty Publications

Importance: Hypertensive disorders of pregnancy (HDP) are a group of high blood pressure disorders during pregnancy that are a leading cause of maternal and infant morbidity and mortality. Data on the trend in the incidence of HDP among the Medicaid population during coronavirus disease of 2019 (COVID-19) are lacking. Objective: To determine the trends in the annual incidence of HDP among pregnant Medicaid-insured women in Louisiana before and during the COVID-19 pandemic (2016–2021). Methods: A total of 113,776 pregnant women aged 15–50 years were included in this study. For multiparous individuals, only the first pregnancy was used in the analyses. …

Changes In Psychological Challenges, Positive Experiences, And Coping Strategies Among International Students In The United States Before And During The Covid-19 Pandemic: A Qualitative Study, Chulwoo Park, Shannon Shimada, Airi Irene Trisnadi, Patricia Angelica

Faculty Research, Scholarly, and Creative Activity

The purpose of this study was to understand how the challenges and coping strategies among international students in the United States changed before and during the COVID-19 pandemic. We conducted a qualitative study through one-on-one in-depth interviews during April–June 2021. A total of 34 international students in the San Francisco Bay Area participated in this study. NVivo was used to analyze the qualitative data. Before COVID-19, the challenges were primarily related to a sense of belonging, such as culture shock, language barriers, and loss of identity. However, some positive experiences from school life and new culture were also found before …

Panel Stacking Is A Threat To Consensus Statement Validity, Kasper P Kepp, Preben Aavitsland, Marcel Ballin, Francois Balloux, Stefan Baral, Kevin Bardosh, Howard Bauchner, Eran Bendavid, Raj Bhopal, Daniel T Blumstein, Paolo Boffetta, Florence Bourgeois, Adam Brufsky, Peter J Collignon, Sally Cripps, Ioana A Cristea, Nigel Curtis, Benjamin Djulbegovic, Oliver Faude, Maria Elena Flacco, Gordon H Guyatt, George Hajishengallis, Lars G Hemkens, Tammy Hoffmann, Ari R Joffe, Terry P Klassen, Despina Koletsi, Dimitrios P Kontoyiannis, Ellen Kuhl, Carlo La Vecchia, Tea Lallukka, John Lambris, Michael Levitt, Spyros Makridakis, Helena C Maltezou, Lamberto Manzoli, Ana Marusic, Clio Mavragani, David Moher, Ben W Mol, Taulant Muka, Florian Naudet, Paul W Noble, Anna Nordström, Peter Nordström, Nikolaos Pandis, Stefania Papatheodorou, Chirag J Patel, Irene Petersen, Stefan Pilz, Nikolaus Plesnila, Anne-Louise Ponsonby, Manuel A Rivas, Andrea Saltelli, Manuel Schabus, Michaéla C Schippers, Holger Schünemann, Marco Solmi, Andreas Stang, Hendrik Streeck, Joachim P Sturmberg, Lehana Thabane, Brett D Thombs, Athanasios Tsakris, Simon N Wood, John P A Ioannidis

Faculty, Staff and Student Publications

Consensus statements can be very influential in medicine and public health. Some of these statements use systematic evidence synthesis but others fail on this front. Many consensus statements use panels of experts to deduce perceived consensus through Delphi processes. We argue that stacking of panel members toward one particular position or narrative is a major threat, especially in absence of systematic evidence review. Stacking may involve financial conflicts of interest, but nonfinancial conflicts of strong advocacy can also cause major bias. Given their emerging importance, we describe here how such consensus statements may be misleading, by analyzing in depth a …

Lessons Learnt From Broad-Spectrum Coronavirus Antiviral Drug Discovery, Andrew A Bolinger, Jun Li, Xuping Xie, Hongmin Li, Jia Zhou

Faculty, Staff and Student Publications

Introduction: Highly pathogenic coronaviruses (CoVs), such as severe acute respiratory syndrome CoV (SARS-CoV), Middle East respiratory syndrome CoV (MERS-CoV), and the most recent SARS-CoV-2 responsible for the COVID-19 pandemic, pose significant threats to human populations over the past two decades. These CoVs have caused a broad spectrum of clinical manifestations ranging from asymptomatic to severe distress syndromes (ARDS), resulting in high morbidity and mortality.

Areas covered: The accelerated advancements in antiviral drug discovery, spurred by the COVID-19 pandemic, have shed new light on the imperative to develop treatments effective against a broad spectrum of CoVs. This perspective discusses strategies and …

Characteristics Of Medically Attended Influenza Infection Across Age Groups Before The Covid-19 Pandemic In Lebanon, Amani Haddara, Zeina Houry, Nada Zahreddine, Mark Atallah, Celina F Boutros, Joseph Tannous, Christian Sadaka, Sarah Wehbe, Tamara Kadi, Ahmad Ibrahim, Rihab Ahmadieh, Tala Kardas, Nadia Soudani, Habib Al Kalamouni, Youssef Zgheib, Noha El Yaman, Sarah Khafaja, Mireille Lteif, Rouba Shaker, Aia Assaf Casals, Yolla Youssef, Nour Youssef, Zeinab El Zein, Sarah Chamseddine, Ahmad Chmaisse, Magda Haj, Danielle Fayad, Shereen Kiblawi, Imad Isaac, Hind Anan, Najwa Radwan, Rima Hanna Wakim, Hassan Zaraket, Souha S Kanj, Ghassan S Dbaibo

Faculty, Staff and Student Publications

Background: Influenza represents a significant global health burden for individuals and society. This study assessed the burden of medically attended influenza at a tertiary medical center in Lebanon to describe the demographics, risk factors, and outcomes prior to the COVID-19 pandemic.

Methods: This was a retrospective review of patients who tested positive for the influenza virus during three seasons between July 1, 2016 to June 30, 2019, at the American University of Beirut Medical Center.

Results: A total of 2049 patients who tested positive for influenza were analyzed. Influenza A accounted for 79.6 % of cases, and influenza B for …

Impact Of Sars-Cov-2 (Covid-19) Infections On Mental Health Diagnoses In Youth With Chronic Illness, Molly Mcvoy, Rina Hung, Irina Bransteter, David W. Miller, Jeffrey A. Dusek, Martha Sajatovic

Faculty Scholarship

Objective: Stressors from the COVID-19 pandemic and limited availability of mental health care services have negatively impacted youth mental health in a significant way. In the first year of the pandemic, global prevalence of anxiety and depression increased by roughly 25% in pediatric populations. While the general trend is clear, this research aimed to explore the added mental health burden of acute COVID-19 on pediatric patients with chronic conditions and describe the differences in mental health outcomes between pediatric patients with 2 common chronic conditions (asthma and diabetes) to better understand specific factors that may increase susceptibility to mental health …

A Prospective Cohort Study Of Pregnancy Outcomes Following Antepartum Infection With Sars-Cov-2, James D Doss, Emily Diveley, Fan Zhang, Amy Scheffer, Ruizhi Huang, Daniel Jackson, Nandini Raghuraman, Ebony B Carter, Indira U Mysorekar, Jeannie C Kelly

Faculty, Staff and Students Publications

Objectives: Our study aimed to explore the impact of COVID-19 infection on pregnancy outcomes, accounting for the progression of variants, vaccines, and treatment modalities.

Study design: We performed a prospective longitudinal cohort study at two urban tertiary centers enrolling patients with a confirmed intrauterine singleton pregnancy from December 23, 2020 to July 18, 2022. Patients were evaluated for SARS-CoV-2 infection at enrollment and every trimester using serum antibody testing. The primary outcome was preterm birth. Symptom and treatment data were collected from pregnant patients with COVID-19 infections. Variant strain infection status was determined from local wastewater analysis.

Results: 448 patients …

Lessons Learned From Ventilated And Proned Patients With Covid-19: A Multisite Retrospective Study To Identify Predictive Factors For Facial Pressure Injuries, Jeanne Hlebichuk, Elissa Buck, Angeline L. Brooker, Julie K. Mackenzie, Maharaj Singh

College of Nursing Faculty Research and Publications

Background

Many patients critically ill with COVID-19 develop acute respiratory distress syndrome (ARDS) necessitating mechanical ventilation and proning. Although proning is lifesaving, it has been linked to the occurrence of facial pressure injuries (PIs).

Objectives

To evaluate the incidence and use of prevention strategies and identify predictors of facial PIs in patients who received ventilator and proning treatments in COVID-designated intensive care units at 2 large quaternary medical centers in the Midwest.

Method

This was a retrospective cohort study using data extracted from an electronic health record between October 2020 and February 2022. Demographics, clinical and care variables, and PI …

Perceived Medical, Social, And Psychological Issues Due To The Covid-19 Pandemic Among Elderly: A Descriptive Analysis, Khushboo Juneja, Kathan Kapoor, Ashwini Kumar, Kundangar Eshwari

Open Access archive

Elderly individuals are more likely to suffer from both short and long-term consequences of COVID19, including exacerbation of existing illnesses, psychological issues, and increased risk of death. This study aimed to understand the medical, perceived psychological, and social health problems faced by the elderly due to the COVID-19 pandemic. This hospital-based study included 225 elderly patients (aged ≥60 years) with chronic health conditions. Hypertension (70.2%) and diabetes mellitus (64.0%) were the most common morbidities among the study participants. At least 34.7% of the participants had one or more symptoms suggestive of psychological problems due to COVID-19 pandemic. Among the participants, …

Covid-19 Infection Wave Mortality From Surveillance Data In The Philippines Using Machine Learning, Julius Migriño Jr, Ani Regina U. Batangan, Rizal Michael R. Abello

Ateneo School of Medicine and Public Health Publications

The Philippines had several COVID-19 infection waves brought about by different strains and variants of SARS-CoV-2. This study aimed to describe COVID-19 outcomes by infection waves using machine learning. A cross-sectional surveillance data review design was employed using the DOH COVID Data Drop dataset as of September 24, 2022. The predominant variant(s) of concern divided the dataset into time intervals representing the infection waves: ancestral (A0), Alpha/Beta (AB), Delta (D), and Omicron (O). Descriptive statistics and machine learning models were generated from each infection. The final data set consisted of 3,896,206 cases wherein 98.39% of cases recovered while 1.61% died. …

Special Supplement Issue On Quality Assurance And Enrichment Of Biological And Biomedical Ontologies And Terminologies, Licong Cui, Ankur Agrawal

Faculty, Staff and Student Publications

Ontologies and terminologies serve as the backbone of knowledge representation in biomedical domains, facilitating data integration, interoperability, and semantic understanding across diverse applications. However, the quality assurance and enrichment of these resources remain an ongoing challenge due to the dynamic nature of biomedical knowledge. In this editorial, we provide an introductory summary of seven articles included in this special supplement issue for quality assurance and enrichment of biological and biomedical ontologies and terminologies. These articles span a spectrum of topics, such as development of automated quality assessment frameworks for Resource Description Framework (RDF) resources, identification of missing concepts in SNOMED …

The Prospect Of Indonesian Herbal As An Alternative Treatment For Covid-19 Patient: A Literature-Based Study, Hadi Sunaryo, Wahyu Hidayati

Indonesian Journal of Medical Chemistry and Bioinformatics

Coronavirus disease 2019 (COVID-19) is a new disease caused by a novel coronavirus, Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). The disease has several symptoms from mild to severe and could lead to death for comorbidities and the elderly. Therefore, the infections and mortality cases keep growing day by day, moreover many authorities are trying to suppress it by applying several health protocols, including medicines. Several studies were conducted on drug discovery from plants to cure the disease. The article aimed to do a narrative review about the prospect of JAMU becoming an alternative medicine to cure COVID-19 by mapping …

Effect Of Covid-19 On Access To Language Services Among Pediatric Hospital Providers In The United States: A Cross-Sectional Survey, Sheela Gavvala, Jessica Gonzalez, Kaleigh Riggs, Raymond Parlar-Chun

Journal of Applied Research on Children: Informing Policy for Children at Risk

Objectives: To survey pediatric hospitalists about their perceptions on 1) access to interpreter services, 2) how the COVID-19 pandemic affected access to interpreter services, and 3) methods and barriers to providing discharge instructions for families who prefer languages other than English (LOE).

Methods:

A cross sectional, observational study was conducted utilizing an online survey via REDCap that was distributed on the Pediatric Hospital Medicine (PHM) LISTSERV® from February 23 to March 23, 2022. Inclusion criteria included faculty and advanced practice providers who practice medicine in a hospital setting greater than 50% of their clinical time as well as medical students, …

Fostering Play In The Covid Crisis: Insights From Infant-Toddler Teachers., Minsun Shin

Department of Teaching and Learning Scholarship and Creative Works

Play is pivotal in supporting young children’s holistic development. The COVID-19 crisis further highlighted the importance of play in supporting children’s well-being and in providing a sense of normalcy. Guided by the phenomenographic method, this study aimed to examine Korean in-service infant-toddler teachers’ experiences in fostering play in early childhood educational classrooms during the COVID-19 crisis. The study involved 10 infant-toddler teachers working with children under the age of three years at a large university-based childcare center. They participated in drawing tasks and in-person focus group interviews. The findings revealed that the pandemic caused and exacerbated barriers to everyday play. …

Editorial: Covid And Autism 2023: Lessons Learnt And Future Directions For Research, Georgina Pérez Liz, Michaela Dubay, Cecilia Montiel-Nava

Psychological Science Faculty Publications

No abstract provided.

Neutralization Escape, Infectivity, And Membrane Fusion Of Jn1-Derived Sars-Cov-2 Slip, Flirt, And Kp2 Variants, Pei Li, Julia N Faraone, Cheng Chih Hsu, Michelle Chamblee, Yi-Min Zheng, Claire Carlin, Joseph S Bednash, Jeffrey C Horowitz, Rama K Mallampalli, Linda J Saif, Eugene M Oltz, Daniel Jones, Jianrong Li, Richard J Gumina, Kai Xu, Shan-Lu Liu

Faculty, Staff and Student Publications

We investigate JN.1-derived subvariants SLip, FLiRT, and KP.2 for neutralization by antibodies in vaccinated individuals, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-infected patients, or class III monoclonal antibody S309. Compared to JN.1, SLip, KP.2, and especially FLiRT exhibit increased resistance to bivalent-vaccinated and BA.2.86/JN.1-wave convalescent human sera. XBB.1.5 monovalent-vaccinated hamster sera robustly neutralize FLiRT and KP.2 but have reduced efficiency for SLip. All subvariants are resistant to S309 and show decreased infectivity, cell-cell fusion, and spike processing relative to JN.1. Modeling reveals that L455S and F456L in SLip reduce spike binding for ACE2, while R346T in FLiRT and KP.2 strengthens …

Creating A Modified Version Of The Cambridge Multimorbidity Score To Predict Mortality In People Older Than 16 Years: Model Development And Validation, Debasish Kar, Kathryn S. Taylor, Mark Joy, Sudhir Venkatesan, Wilhelmine Meeraus, Sylvia Taylor, Sneha N. Anand, Filipa Ferreira, Gavin Jamie, Xuejuan Fan, Simon De Lusignan

Peninsula Medical School

Background: No single multimorbidity measure is validated for use in NHS (National Health Service) England’s General Practice Extraction Service Data for Pandemic Planning and Research (GDPPR), the nationwide primary care data set created for COVID-19 pandemic research. The Cambridge Multimorbidity Score (CMMS) is a validated tool for predicting mortality risk, with 37 conditions defined by Read Codes. The GDPPR uses the more internationally used Systematized Nomenclature of Medicine clinical terms (SNOMED CT). We previously developed a modified version of the CMMS using SNOMED CT, but the number of terms for the GDPPR data set is limited making it impossible to …