Digital Commons Network^™

The Contribution Of Neutrophil Extracellular Traps To Coagulopathy In Patients With Covid-19-Related Thrombosis, Carolyn Enochs, Gabriela Delevati Colpo, Lucy Couture, Lynae Baskin, Ana E Cahuiche, Eunyoung Angela Lee, Shahid Nimjee, Louise D Mccullough

Faculty, Staff and Student Publications

COVID-19 is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and is associated with hypercoagulability and increased incidence of thrombotic events. In this study, we investigated the levels of neutrophil extracellular trap biomarkers and von Willebrand factor to assess if these could predict the occurrence of a thrombotic event in COVID-19 patients. We enrolled 202 patients hospitalized with symptomatic COVID-19 infection. Of those, 104 patients did not experience any type of thrombotic events before or during their hospitalization. These patients were compared to the other cohort of 98, who experienced thrombotic events before or during their hospitalization. In total, …

Tracking Modifications To Implementation Strategies: A Case Study From Snap - A Hybrid Type Iii Randomized Controlled Trial To Scale Up Integrated Systems Navigation And Psychosocial Counseling For Pwid With Hiv In Vietnam, Minh X Nguyen, Sophia M Bartels, Christopher F Akiba, Teerada Sripaipan, Ha Tt Nong, Linh Th Dang, Ha V Tran, Van Th Hoang, Giang M Le, Vivian F Go, William C Miller, Byron J Powell

2020-Current year OA Pubs

INTRODUCTION: Evaluation of implementation strategies is core to implementation trials, but implementation strategies often deviate from the original plan to adjust to the real-world conditions. The optimal approach to track modifications to implementation strategies is unclear, especially in low-resource settings. Using data from an implementation trial for people who inject drugs (PWID) with HIV in Vietnam, we describe the tracking of implementation strategy modifications and present findings of this process.

METHODS: SNaP (Systems Navigation and Psychosocial Counseling) is a hybrid type-III effectiveness-implementation randomized controlled trial aiming to scale up the evidence-based intervention, integrated systems navigation and psychosocial counseling, for PWID …

Prescription Practices, Anti-Psychotics, And Covid-19: An Intersectional Examination Of The Long-Term Care Home Setting In Canada, Olivia Ramos

Dalhousie Journal of Legal Studies

Public discourse and concern over the state of long-term care homes in Canada has been ongoing over the last two decades. One of the main sources of these concerns is the off-label prescription of anti-psychotic medications to long-term care home residents. Off-label use of pharmaceuticals is common and can be beneficial in certain contexts, however, there is a risk of anti-psychotics being used as an inappropriate means of managing patients chemically in the long-term care home setting. This paper engages in three lines of inquiry: first, the regulatory landscape of on and off-label prescription in Canada; second, the off-label use …

Characterization Of Collaborative Cross Mouse Founder Strain Cast/Eij As A Novel Model For Lethal Covid-19., Candice N Baker, Debra Duso, Nagarama Kothapalli, Tricia Hart, Sean Casey, Tres Cookenham, Larry Kummer, Janine Hvizdos, Kathleen Lanzer, Purva Vats, Priya Shanbhag, Isaac Bell, Mike Tighe, Kelsey Travis, Frank Szaba, Jeffrey M. Harder, Olivia Bedard, Natalie Oberding, Jerrold M Ward, Mark D Adams, Cathleen Lutz, Shelton S Bradrick, William W Reiley, Nadia Rosenthal

Faculty Research 2024

Mutations in SARS-CoV-2 variants of concern (VOCs) have expanded the viral host range beyond primates, and a few other mammals, to mice, affording the opportunity to exploit genetically diverse mouse panels to model the broad spectrum of responses to infection in patient populations. Here we surveyed responses to VOC infection in genetically diverse Collaborative Cross (CC) founder strains. Infection of wild-derived CC founder strains produced a broad range of viral burden, disease susceptibility and survival, whereas most other strains were resistant to disease despite measurable lung viral titers. In particular, CAST/EiJ, a wild-derived strain, developed high lung viral burdens, more …

Aromatase, Testosterone, Tmprss2: Determinants Of Covid-19 Severity, Eric C Mohan, Jude P J Savarraj, Gabriela D Colpo, Diego Morales, Carson E Finger, Alexis Mcalister, Hilda Ahnstedt, Huimahn Choi, Louise D Mccullough, Bharti Manwani

Faculty, Staff and Student Publications

Background: Male sex has been identified as a risk factor for worse COVID-19 outcomes. This sex difference has been mostly attributed to the complex role of sex hormones. Cell surface entry of SARS-CoV-2 is mediated by the transmembrane protease serine 2 (TMPRSS2) which is under transcriptional regulation by androgens. P450 aromatase enzyme converts androgens to estrogens. This study measured concentrations of aromatase enzyme, testosterone, estradiol, and TMPRSS-2 in plasma of hospitalized COVID-19 patients to elucidate the dynamics of sex-linked disparity in COVID-19 and correlate them with disease severity and mortality.

Methods: In this prospective cohort study, a total of 265 …

University Students Speak Out: Suggestions To Improve The Move To Emergency Remote Education, Pauline Howes, Justine E. Pettigrew

Faculty Articles

The 2020 COVID-19 crisis forced universities to make a dramatic shift to emergency remote education (ERE). While the urgency of the pandemic is gone, schools continue implementing ERE, but more often on a short-notice, short-term basis in response to various situations. This research examines students’ suggestions for improving university transitions to ERE and applies them to post-pandemic use of ERE. Qualitative thematic analysis was used to analyze responses to an open-ended survey question answered by 2,751 students at a large Southeastern U.S. university. Responses identified main concerns as Grades and Grading (38%), Better University and Instructor Preparation (23%), Improved Learning …

Exploring Determinants Of Transit Recovery After The Covid-19 Pandemic, Udit Khandelwal

Dissertations and Theses

The COVID-19 pandemic significantly disrupted public transit systems across the US, resulting in substantial declines in ridership and revenue. At the same time, ridership has increased to different levels in cities. This thesis explores the determinants of transit recovery in American cities post-pandemic. It analyzes data from the National Transit Database (NTD) and employs a two-stage least squares (2SLS) regression model first laid out by Taylor et al. (2008) for data from 2000. Similar to the results of that paper, the thesis finds strong correlation between transit ridership and variables for transit supply and urban and demographic characteristics for 2019 …

Micrornas Are Enriched At Covid-19 Genomic Risk Regions, And Their Blood Levels Correlate With The Covid-19 Prognosis Of Cancer Patients Infected By Sars-Cov-2, Simone Anfossi, Faezeh Darbaniyan, Joseph Quinlan, Steliana Calin, Masayoshi Shimizu, Meng Chen, Paola Rausseo, Michael Winters, Elena Bogatenkova, Kim-Anh Do, Ivan Martinez, Ziyi Li, Loredana Antal, Tudor Rares Olariu, Ignacio Wistuba, George A Calin

Faculty, Staff and Student Publications

Background: Cancer patients are more susceptible to an aggressive course of COVID-19. Developing biomarkers identifying cancer patients at high risk of COVID-19-related death could help determine who needs early clinical intervention. The miRNAs hosted in the genomic regions associated with the risk of aggressive COVID-19 could represent potential biomarkers for clinical outcomes.

Patients and methods: Plasma samples were collected at The University of Texas MD Anderson Cancer Center from cancer patients (N = 128) affected by COVID-19. Serum samples were collected from vaccinated healthy individuals (n = 23) at the Municipal Clinical Emergency Teaching Hospital in Timisoara, Romania. An in …

Impacts Of The Covid-19 Pandemic On Intimate Partner Violence And Child Maltreatment Services In Rural Northwest North Carolina, Elisabeth G. Galphin, Adam Hege, Amy Dellinger Page

Journal of Appalachian Health

The current study examined the impact of the COVID-19 pandemic on IPV and child maltreatment services in rural northwestern North Carolina. Qualitative interviews were conducted with eight professionals representing six service organizations across four counties. The findings highlighted challenges these agencies faced throughout the pandemic, new risks for the clients served, and positive outcomes. In addition, it has been a useful learning experience as public health and social service agencies learn to serve their communities more effectively moving forward. This is especially relevant for rural communities, as it has put public health preparedness at the forefront.

Using Public Funeral And Obituary Listings To Identify Spikes In Excess Mortality In One Appalachian County, Allen Archer, Melissa White, Megan Quinn, Randy Wykoff

Journal of Appalachian Health

Introduction: Delays (10-22 months) in availability of official state and county-level mortality data could have significant public health consequences. The COVID-19 pandemic illuminated the need for health officials to access timely death data to identify unexpected increases in mortality in their communities.

Purpose: The purpose of this study is to determine if funeral home listings and/or newspaper obituaries could help identify excess mortality on the local level, prior to the availability of official death records.

Methods: To calculate excess mortality, four years (2017–2020) of data were collected from three sources: the state health department, online funeral home listings, and newspaper …

Refereed Research - Religiosity And Sociality As Sources Of Resilience For Women Subsistence Entrepreneurs During The Pandemic, Rozina Akther

Subsistence Marketplaces

This study examines challenges faced by subsistence women entrepreneurs during COVID-19, the crisis of 2020, and their resilience in addressing the circumstances. The results of qualitative interviews with 13 subsistence marketplace women entrepreneurs in Bangladesh are presented in this article. In the current study, two themes are found to best capture the experiences and resilience of women business owners in the subsistence marketplaces. Furthermore, the study provides important insights from informant interviews, showing how women business owners navigate their operations during a pandemic. It highlights attributes such as relational strength and faith in a higher power that contribute to their …

Role Of Ct-Based Body Composition Parameters In The Course Of Covid-19, Elçi̇n Aydin, Begüm Ergi̇n, Ezgi̇ Güvel Verdi̇, Özge Coşkun, Şükrü Şahi̇n, Ali̇ Haydar Baykan, Hi̇lal Şahi̇n

Turkish Journal of Medical Sciences

Background/aim: A significant correlation is observed between the course of coronavirus disease 2019 (COVID-19) and body composition parameters including visceral fat quantification, muscle mass, and hepatic attenuation. The aim of the study was to investigate the correlation between the extent of lung involvement and various computed tomography (CT) parameters, as well as laboratory findings in COVID-19 patients.Materials and methods: A retrospective analysis was conducted on 72 adult patients with laboratory-confirmed severe acute respiratory syndrome coronavirus 2 infection who underwent two consecutive thorax CT scans at least 2 weeks apart. The patients were divided into two groups, as progressive and nonprogressive, …

Evaluation With Structural Equation Modeling Of Variables Affecting Health-Seeking Behaviors During The Covid-19 Pandemic In İstanbul, Türkiye, Pinar Atali, Seyhan Hidiroğlu, Ali̇can Sarisaltik, Melda Karavuş

Turkish Journal of Medical Sciences

Background/aim: The relation between the demographic characteristics of individuals and their health-seeking behaviors was presented and the effects of health cognitions, healthy lifestyle behaviors, and coronavirus fear levels on health-seeking behaviors during the COVID-19 pandemic were examined.Materials and methods: This descriptive survey study was conducted in the Tuzla District of İstanbul, Türkiye, between March and June 2021. Results: From analysis of the 391 participants, 60.0% were females, 27.1% were between 31 and 40 years of age, 47.0% were healthcare professionals, and the perceived socioeconomic status of 50.9% was above average. According to the results, the women exhibited more health-seeking behavior …

“I Had No Idea”: At-Risk College Student Knowledge Of Financial Aid And Resources, Elizabeth A. Rainey, Zach W. Taylor

Journal of Student Financial Aid

Although research has explored what college students struggle to understand about financial aid, no research has investigated how at-risk students on financial aid probation articulate their financial aid knowledge and the gaps in that knowledge. As a result, this content analysis investigates online discussion board posts from a credit-bearing student success course for at-risk students (GPA < 2.00 or below a 67% completed over attempted credit hours ratio) to learn how these students conceptualized their financial aid knowledge and how prior knowledge could have helped them before reaching probationary financial aid status. This study involved 110 students across three semesters in the midst of the COVID-19 pandemic. Findings suggest students lacked financial aid knowledge to plan their college career, specifically with student loans. They relied on a range of familial resources, but were often unaware that their academic progress was tied to their financial aid. Implications for research, policy, and practice are addressed.

Modern Band Music Teachers' Adoption Of A Community Music Ethos In Online Teaching During The Covid-19 Pandemic, Bryan Powell, Gareth Dylan Smith, Warren Gramm, David Knapp

Visions of Research in Music Education

At intersections of popular music education, music technology, and community music practices, music teachers in the United States adapted to teaching and learning during the COVID-19 pandemic, specifically from March 2020 to March 2021. The purpose of this research was to better understand the perspectives of modern band teachers regarding the opportunities and challenges of teaching music during the pandemic. The researchers interviewed four teachers who taught modern band (popular music) in public schools in geographically and demographically distinct parts of the US and found that each educator adopted a community music ethos in the online environment. An analysis of …

Effect Of Covid-19 Vaccination On Covid-19 Mortality By Age In Georgia, Brennan Bogdanovich, Mckenzie E. Maloney, James Pollock, Lane Langston, Brittany Ange, Jack Yu

Journal of the Georgia Public Health Association

Purpose: The COVID-19 epidemic led to significant morbidity and mortality globally, especially among the elderly. Because SARS-CoV-2 is a novel viral pathogen, there was a lack of preventative and treatment options. Availability of effective vaccines has been an important factor in determining the epidemic trajectory. Analyzing the effects of the vaccines in reducing mortality across age groups is important for guiding future public health responses. The objective of this study was to determine the association between age and COVID-19 mortality pre- and post-vaccination periods amongst Georgians.

Methods: This cross-sectional study used COVID-19 case numbers, COVID-19 deaths, age at time of …

Stemming The Flow: Strategies To Address The Production Arts Skills Shortage Within Australian Theatre And Performance Practice, Tessa Rixon, Anthony Brumpton

Behind the Scenes: Journal of Theatre Production Practice

The lockdown, cancellations, and uncertainties of COVID-19 triggered a large-scale exit of skilled professional technicians, managers, and designers from the Australian arts industry. A significant gap in the national workforce of production artists has since emerged, forcing arts organisations to work with smaller teams and employ younger people with little to no training or knowledge. These pressures are beginning to impact the industry’s ability to meet the post-COVID demand to stage live performances, yet little information has been collected to fully comprehend the issue or to suggest solutions.

Conducted throughout 2023, this research sought to understand the current situation of …

Racial Residential Segregation And Covid-19 Health Outcomes: Evidence From The State Of Georgia, Palak Patel, Simon Medcalfe, Catherine P. Slade

Journal of the Georgia Public Health Association

ABSTRACT

Background:

According to the Georgia Department of Public Health (GDPH), the state of Georgia reported 563,658 cumulative COVID-19 cases and 9,845 total deaths in 2020. Decades of research on racial disparities in health outcomes suggest we should not be surprised with the disproportionate number of cases, hospital visits, and deaths of non-white and Black Georgia residents. Racial disparities in health are often defined by a Social Determinants of Health (SDOH) model. One understudied SDOH is racial residential segregation. In this study we explore the relationship between racial residential segregation and COVID-19 health outcomes. Our paper addresses critical challenges for …

Understanding The Role Of Perceived Racial Discrimination On Adolescent Mental Health During The Covid-19 Pandemic, Jill V. Klosky, Delia Lang, Briana Woods-Jaeger, Julie Gazmararian

Journal of the Georgia Public Health Association

Abstract

Background: Adolescent mental health declined during the COVID-19 pandemic. Racial discrimination, which may negatively affect adolescent mental health, has increased. This study sought to understand whether pre-pandemic reports of racial discrimination predicted changes in adolescent depression, anxiety, and self-esteem from before to during the COVID-19 pandemic.

Methods: Two online surveys were administered at two public high schools in semi-rural, north-central Georgia; one in Spring 2020, just before the closing of public schools due to COVID-19; the other to the same students in Fall 2020.

Results: Most participants were White (62%) and the majority (88%), reported the same or better …

Pandemic Perspectives From Detained Youth During Covid-19: Bridging The Knowledge Gap For Future Safeguards., April Mcneill-Johnson, Zuri Hudson, Brittany Moore, Dumebi Okocha, Megha Ramaswamy, Kimberly Randell

Manuscripts, Articles, Book Chapters and Other Papers

Despite the worsening health disparities among youth in detention during the COVID-19 pandemic, there has been minimal exploration into the pandemic experiences of detained youth and opportunities for pandemic mitigation. This paper analyzes the perspectives of youth in detention on the pandemic, including the effect of the pandemic on their detention experience and their perceptions about COVID-19 vaccination. The study used purposive sampling to recruit 16 participants (aged 14-17 years) from two juvenile detention centers in the urban Midwest. We conducted semi-structured interviews and analyzed verbatim transcripts using a hybrid deductive-inductive approach and thematic analysis. Four themes emerged: 1) personal …

Estimates Of Actual And Potential Lives Saved In The United States From The Use Of Covid-19 Convalescent Plasma, Quigly Dragotakes, Jeffrey P Henderson, Et Al.

2020-Current year OA Pubs

In the Spring of 2020, the United States of America (USA) deployed COVID-19 convalescent plasma (CCP) to treat hospitalized patients. Over 500,000 patients were treated with CCP during the first year of the pandemic. In this study, we estimated the number of actual inpatient lives saved by CCP treatment in the United States of America based on CCP weekly use, weekly national mortality data, and CCP mortality reduction data from meta-analyses of randomized controlled trials and real-world data. We also estimate the potential number of lives saved if CCP had been deployed for 100% of hospitalized patients or used in …

Understanding Long Covid: Navigating The Journey To Recovery, Heather H. Kelley, Rachel Byers, Ty Aller, Timothy Keady

All Current Publications

This fact sheet provides very basic facts on what long COVID is and information on how to navigate the healthcare system and cope with long COVID.

Human Epidemiology And Response To Sars-Cov-2 (Heros): Objectives, Design, And Enrollment Results Of A 12-City Remote Observational Surveillance Study Of Households With Children, Using Direct-To-Participant Methods, Patricia C Fulkerson, Katherine Rivera-Spoljaric, Et Al.

2020-Current year OA Pubs

The Human Epidemiology and Response to SARS-CoV-2 (HEROS) Study is a prospective, multicity, 6-month incidence study conducted from May 2020 to February 2021. The objectives were to identify risk factors for SARS-CoV-2 infection and household transmission among children and people with asthma and allergic diseases, and to use the host nasal transcriptome sampled longitudinally to understand infection risk and sequelae at the molecular level. To overcome challenges of clinical study implementation due to the coronavirus pandemic, this surveillance study used direct-to-participant methods to remotely enroll and prospectively follow eligible children who are participants in other National Institutes of Health-funded pediatric …

Disclosure Patterns Of Opioid Use Disorders In Perinatal Care During The Opioid Epidemic On X From 2019 To 2021: Thematic Analysis, Dezhi Wu, Minnie Ng, Saborny Sen Gupta, Phyllis Raynor Phd, Aprn, Pmhnp-Bc, Youyou Tao, Yang Ren, Peiyin Hung, Shan Qiao, Jiajia Zhang, Jennifer Fillo, Xiaoming Li, Constance Guille, Kacey Eichelberger, Bankole Olatosi

Publications

BACKGROUND: In 2021, the United States experienced a 14% rise in fatal drug overdoses totaling 106,699 deaths, driven by harmful opioid use, particularly among individuals in the perinatal period who face increased risks associated with opioid use disorders (OUDs). Increased concerns about the impacts of escalating harmful opioid use among pregnant and postpartum persons are rising. Most of the current limited perinatal OUD studies were conducted using traditional methods, such as interviews and randomized controlled trials to understand OUD treatment, risk factors, and associated adverse effects. However, little is known about how social media data, such as X, formerly known …

Teacher Retention Challenges: What We Learned Before And After Covid-19, Brenda Morton, Edd., Joel Maresh Edd

Northwest Journal of Teacher Education

The COVID-19 pandemic exacerbated the already elevated stress levels among teachers, leading to contemplation of leaving the profession. As educators were compelled to transition to online teacher, they suddenly found themselves immersed in the households of their students, an entirely novel experience. This newfound proximity granted teachers insight into various aspects of the students’ lives, including family dynamics, home environments, levels of household stress, and the accessibility of essential resources. In addition to the teaching duties, educators were tasked with the development of online curricula, the acquisition of online learning resources, and providing support to parents and families during a …

Sars-Cov-2 Vaccine Improved Hemostasis Of A Patient With Protein S Deficiency: A Case Report, Mohammad A. Mohammad, Alaa Malik, Lekha Thangada, Diana Polanía-Villanueva, Jovanny Zabaleta, Rinku Majumder

School of Medicine Faculty Publications

A 16-year-old patient, while an infant, incurred right-sided hemiparesis and had difficulty breast feeding. She was later diagnosed with a neonatal stroke and her genetic testing showed a missense mutation in her PROS1 (Protein S) gene. Both her grandfather and father, but not her mother, had hereditary Protein S (PS) deficiency. The patient was not prescribed any mediation due to her young age but was frequently checked by her physician. The patient’s plasma was first collected at the age of 13, and the isolated plasma from the patient and her father were analyzed by aPTT, thrombin generation, and enzyme-linked immunosorbent …

Increased Myositis And Possible Myocarditis In Melanoma Patients Treated With Immune Checkpoint Inhibitors In The Covid-19 Era, Allison L. Gradone, Vincent T Ma, Alexi Vasbinder, Leslie A Fecher, Sarah Yentz, Salim S Hayek, Christopher D Lao

Department of Medical Oncology Faculty Papers

BACKGROUND: Immune checkpoint inhibitor (ICI)-mediated myocarditis results in significant morbidity and mortality. At our institution, we noted an increased incidence of ICI-mediated myocarditis cases, leading to further investigation in our database of advanced melanoma patients treated with ICI therapy.

METHODS: A single-center, retrospective cohort analysis of patients with advanced melanoma identified cases of ICI-mediated myocarditis and myositis.

RESULTS: 366 patients with advanced melanoma received a dose of ICI from September 2014 to October 2019. Of these patients, there were 0 cases of ICI-mediated myocarditis (0%, 95% CI 0%-1.0%) and 2 cases of ICI-mediated myositis (0.55%, 95% CI 0.07%-1.96%). From November …

How Have Occupational Therapy Services Been Delivered During The Covid-19 Pandemic?, Hulya Yucel, Selen Aydoner

Internet Journal of Allied Health Sciences and Practice

The provision of traditional healthcare services has encountered obstacles due to the Coronavirus Disease-2019 (COVID-19) pandemic. The inability of healthcare professionals and clients to survive the pandemic and the inadequacy of personal protective equipment have created uncertainties regarding the appropriate practices for addressing individuals' health conditions. Furthermore, the field of rehabilitation, including occupational therapy, has experienced changes in the delivery of traditional practices. Therefore, this review aimed to examine occupational therapy services delivered during the COVID-19 pandemic. As a result of the literature review, the most commonly provided services by occupational therapists during COVID-19 were discussed and a total of …

My Journey With Tinnitus, Jack Curtain

Narrative Medicine: Essays on Health and Care

No abstract provided.

Retrospective Analysis Of Sars-Cov-2 Rna Detection In Pooled Saliva Samples: An Effective Cost Saving Method., Jiraphat Charoenkupt, Arkom Chaiwongkot, Ati Burassakarn, Pokrath Hansasuta

Chulalongkorn Medical Journal

Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a causative agent of coronavirus disease 2019 (COVID-19), first reported in December 2019. The virus rapidly spread throughout the globe. Laboratory investigations play an essential role in the early and effective detection of SARS-CoV-2-infected individuals to prevent transmission.

Objectives: The saliva pooling system to screen SARS-CoV-2 in the population has been applied to increase the surveillance widely and conveniently among healthcare personnel at King Chulalongkorn Memorial Hospital. The Ct-values of positive pools and positive individual samples were compared, and the cost effectiveness was also evaluated.

Methods: The retrospective study was conducted …