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Locked Up And Locked Down In The Land Of Free: A Look At The United States' Prisons And Covid-19'S Disproportionate Effect On Black Americans' Right To Health, Zachary Parrish

American University International Law Review

The United States is infamous for having a large percentage of its population in prison. Each year since 2002, the United States has reported a higher incarceration rate than any other country in the world. Another unfortunate but widely prevalent issue that the United States has is systemic racism. The combination of the United States’ struggles with systemic racism and mass incarceration makes for a disproportionately devastating impact on Black Americans. As a result, Black Americans make up a disproportionate amount of the prisoners that fill American prisons.

An Evaluation Of The Results Of Convalescent Plasma Therapy Applied To Pregnant Womendiagnosed As Covid-19- Positive In A Pandemic Center: A Prospective Cohort Study, Seyi̇t Ahmet Erol, Atakan Tanaçan, Hakan Apaydin, Şule Göncü Ayhan, Deni̇z Oluklu, Derya Uyan Hendem, Serpi̇l Ünlü, Abdulsamet Erden, Özlem Moraloğlu Teki̇n, Ahmet Omma, İhsan Ateş, Orhan Küçükşahi̇n, Di̇lek Şahi̇n

Turkish Journal of Medical Sciences

Background/aim: Convalescent plasma (CP) might be an additional treatment modality in COVID-19. The aim of this study was to compare CP-related clinical characteristics and perinatal outcomes in pregnant women with mild or moderate-severe COVID-19. Materials and methods: This prospective cohort study included 36 pregnant women (12 mild and 24 moderate-severe), who underwent CP therapy. The CP obtained from recently recovered donors was transfused to patients together with maximum supportive care and antiviral agents. The groups were then compared in respect of clinical characteristics, laboratory parameters, obstetric complications, and neonatal outcomes. Results: Significant differences were determined between the groups in respect …

The Effect Of Frailty On The Development Of Acute Kidney Injury In Critically-Ill Geriatric Patients With Covid-19, Murat Küçük, Bi̇şar Ergün, Mehmet Nuri̇ Yakar, Özer Ural Çakici, Erdem Yaka, Bi̇lgi̇n Cömert, Ali̇ Necati̇ Gökmen, Begüm Ergan

Turkish Journal of Medical Sciences

Background/aim: Acute kidney injury is strongly associated with mortality in critically ill patients with coronavirus disease 2019 (COVID-19); however, age-related risk factors for acute kidney injury are not clear yet. In this study, it was aimed to evaluate the effects of clinical factors on acute kidney injury development in an elderly COVID-19 patients. Materials and methods: Critically ill patients (?65years) with COVID-19 admitted to the intensive care unit were included in the study. Primary outcome of the study was the rate of acute kidney injury, and secondary outcome was to define the effect of frailty and other risk factors on …

Evaluation Of Metabolic Changes In Fdg Pet/Ct Imaging After Mrna-Based Covid-19 Vaccination, Serkan İşgören, Gi̇zem Köroğlu, Gözde Dağliöz Görür, Hakan Demi̇r

Turkish Journal of Medical Sciences

Background/aim: It isimportant to evaluate the vaccine-related metabolic changes on FDG PET/CT to avoid confusing results. We here aimed to assess the frequency and intensity of regional and systemic metabolic PET/CT changes of patients who received the mRNAbased COVID-19 vaccine (BNT162b2-Pfizer/BioNTech) and to analyze possible factors affecting these changes. Materials and methods: Among the patients who underwent FDG PET/CT for any indication in our department between July 2021 and December 2021, 129 volunteer patients with a history of COVID-19 vaccination were included in this prospective observational study. Bilateral axillary lymph nodes, ipsilateral deltoid muscle, bone marrow, spleen, thyroid, and liver …

A Systematic Review Of Rdrp Of Sars-Cov-2 Through Artificial Intelligence And Machine Learning Utilizing Structure-Based Drug Design Strategy, Fariha Imtiaz, Mustafa Kamal Pasha

Turkish Journal of Chemistry

Since the coronavirus disease has been declared a global pandemic, it had posed a challenge among researchers and raised common awareness and collaborative efforts towards finding the solution. Caused by severe acute respiratory coronavirus syndrome-2 (SARS-CoV-2), coronavirus drug design strategy needs to be optimized. It is understandable that cognizance of the pathobiology of COVID-19 can help scientists in the development and discovery of therapeutically effective antiviral drugs by elucidating the unknown viral pathways and structures. Considering the role of artificial intelligence and machine learning with its advancements in the field of science, it is rational to use these methods which …

Synthesis, Characterization, Computational Analyses, In Silico Admet Studies, And Inhibitory Action Against Sars-Cov-2 Main Protease (Mpro) Of A Schiff Base, Songül Şahi̇n, Necmi̇ Dege

Turkish Journal of Chemistry

COVID-19 disease caused by the severe acute respiratory syndrome coronavirus (SARS-CoV-2) has struck the whole world and raised severe health, economic, and social problems. Many scientists struggled to find a vaccine or an antiviral drug. Eventually, both vaccines and recommended drugs, repurposed drugs, or drug combinations were found, but new strains of SARS-CoV-2 continue to threaten human life and health. As part of the fight against COVID-19 disease, this study involves an in silico molecular docking analysis on the main protease (Mpro) of SARS-CoV-2. To this aim, a Schiff base compound was synthesized and characterized using spectroscopic techniques, including X-ray, …

Guide On Multisectional Responses For The Protection Of Migrants, Refugees, And Internally Displaced Persons During And After The Covid-19 Pandemic, Diego Rodriguez-Pinzon, Claudia Martin

Research Reports & White Papers

The Guide on Multisectoral Responses for the Protection of Migrants, Refugees, and Internally Displaced Persons during and after the COVID19 pandemic is an initiative of the Department of Social Inclusion of the Secretariat for Access to Rights and Equity of the Organization of American States (OAS) that offers a situational analysis and promotes a dialogue on proposals to address the particular needs of migrants, refugees, and internally displaced persons in the face of the emergency generated by COVID-19. It also seeks to define proposals with a post-pandemic perspective that provide multisectoral responses to address the needs of vulnerable populations.

This …

When Exemptions Discriminate: Unlawfully Narrow Religious Exemptions To Vaccination Mandates By Private Colleges And Universities, Ronald J. Colombo

Western New England Law Review

Numerous colleges and universities have imposed COVID-19 vaccination mandates upon their students. Most of these mandates also include language purporting to recognize medical and religious exemptions. With regard to religious exemptions, some are unjustly discriminatory. Most notably, some give preference to students who are members of organized religions over students who are not. And even facially neutral exemptions can be administered in an unjustly discriminatory way by, for example, giving preference to one set of religious denominations over another, or by engaging in “religious profiling” (whereby students of a particular denomination are held completely beholden to the beliefs of that …

Exploring Late Adopter Motivation: A Corona Virus (Covid-19) Vaccine Quality Improvement Project, Brandi D. Giles

MUSC Theses and Dissertations

Lower than ideal COVID-19 vaccination rates are problematic nationally. As of March 4th, 2022 65% of eligible Americans were fully vaccinated (CDC, 2022). South Carolina fell below the national rate with only 57% of eligible South Carolinians were fully vaccinated at the same time period (SCDHEC, 2022). Both rates are below the national goal that was set for nation of 70% of eligible Americans being fully vaccinated by July 4th, 2021. This project aimed at exploring the motivation of individuals who would be considered late adopters. It was found that motivation to become vaccinated was varied and personal. The conclusion …

Characterizing Introductions Of Sars-Cov-2 To The U.S. Virgin Islands Using Pathogen Genomic Surveillance, Kendall Billig

Public Health Theses

Pathogen genomic surveillance systems have proven invaluable throughout the course of the global COVID-19 pandemic. Despite this, genomic surveillance programs are under-resourced or nonexistent in regions with reduced access to advanced public health tools, like the Caribbean. In this study, we documented and evaluated the establishment of a genomic surveillance system in the U.S. Virgin Islands during 2021, and used data from the program to place the story of COVID-19 in the U.S. Virgin Islands in a global context. We constructed a phylogenetic tree and conducted phylogeographic analyses to estimate the timing and geographic origin of the most recent common …

Readability Of Covid-19 Parental Guidance Documents, Amber M. Gordon B.S, Kurustun S. Musick B.S., Alison R. King Ph.D., Ccc-Slp, Lsls Cert. Avt, Erin Stehle Wallace Ph.D., Ccc-Slp

The Journal of Special Education Apprenticeship

The purpose of this study is to examine the readability levels of the state departments of education guidance documents regarding COVID-19 protocols for families of students receiving special education services. The authors searched the 50 states and the District of Columbia’s departments of education websites for their COVID-19, special education, parental guidance documents for the 2020-2021 school year. Parental guidance documents were available from 90% (46/51) of the department of education websites with 61% (31/51) of those documents specifically designed for parents of children receiving special education services. The researchers used the Flesch Reading Ease (FRES) to analyze the reading …

Cultivating Community Stewards: Wellbeing, Belonging, And The Campus Garden, Katherine Clay

West Chester University Master’s Theses

This thesis seeks to prepare college students for adulthood by understanding them as “whole” people, multi-faceted and knowledgeable in their own right. Using the campus garden as a vehicle, participants will engage with surface-level health concepts, the campus environment, and their wider community to develop practical skills, social support systems, and a sense of civic engagement. As participants learn the skills to manage their own wellbeing in times of external stress, they will come to understand themselves as belonging to a community and in turn, develop an investment and commitment to their communities as community stewards. My intervention, The Ivy …

Analyzing The Academic Achievement Of Secondary Virtual Learners During The Covid-19 Pandemic: A Mixed Methods Case Study, Christina Kaye Board

Dissertations and Theses

Secondary students from a mid-sized school district in the rural Midwest who had chosen an asynchronous learning environment during the COVID-19 pandemic were analyzed to determine predictors of academic achievement and perceptions of their learning during the pandemic. An explanatory, mixed methods case study was conducted to sequentially analyze quantitative data and qualitatively analyze their experiences. Archival data from 288 students [F(7, 281) = 20.87, p < .001] was used predict grade point average (GPA) during virtual learning (M = 2.43, SD = 0.89) using a multiple linear regression (R2 = .326). This study was done to determine what factors help educators understand the variables that aide in student achievement while virtual learning. Predictor variables included race/ethnicity, sex, socioeconomic status, grade level, past attendance, past GPA, and number of parents/guardians in the home. Significant predictors were grade level, past GPA (M = 3.05), and sex. The focus of the qualitative research was on access to technology, digital literacy, attitude, motivation, and social connectedness prior to, during, and post-virtual learning. Four themes emerged. Results from this study suggest that schools should consider the type of virtual environment they provide, instructional design that includes social interaction, and professional development for staff prior to implementation of a virtual learning environment to increase achievement.

An Issue Of Concern: Unique Truncated Orf8 Protein Variants Of Sars-Cov-2, Sk. Sarif Hassan, Vaishnavi Kodakandla, Elrashdy M. Redwan, Kenneth Lundstrom, Pabitra Pal Choudhury, Tarek Mohamed El-Aziz, Kazuo Takayama, Ramesh Kandimalla, Amos Lal, Ángel Serrano-Aroca, Gajendra Kumar Azad, Alaa A.A. Aljabali, Giorgio Palù, Gaurav Chauhan, Parise Adadi, Murtaza Tambuwala, Adam M. Brufsky, Wagner Baetas-Da-Cruz, Debmalya Barh, Vasco Azevedo, Nikolas G. Bazan, Bruno Silva Andrade, Raner José Silva, Vladimir N. Uversky

Molecular Medicine Faculty Publications

Open reading frame 8 (ORF8) shows one of the highest levels of variability among accessory proteins in Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), the causative agent of Coronavirus Disease 2019 (COVID-19). It was previously reported that the ORF8 protein inhibits the presentation of viral antigens by the major histocompatibility complex class I (MHC-I), which interacts with host factors involved in pulmonary inflammation. The ORF8 protein assists SARS-CoV-2 in evading immunity and plays a role in SARS-CoV-2 replication. Among many contributing mutations, Q27STOP, a mutation in the ORF8 protein, defines the B.1.1.7 lineage of SARS-CoV-2, engendering the second wave of …

Shell Disorder Models Detect That Omicron Has Harder Shells With Attenuation But Is Not A Descendant Of The Wuhan-Hu-1 Sars-Cov-2, Gerard Kian-Meng Goh, A. Keith Dunker, James A. Foster, Vladimir N. Uversky

Molecular Medicine Faculty Publications

Before the SARS-CoV-2 Omicron variant emergence, shell disorder models (SDM) suggested that an attenuated precursor from pangolins may have entered humans in 2017 or earlier. This was based on a shell disorder analysis of SARS-CoV-1/2 and pangolin-Cov-2017. The SDM suggests that Omicron is attenuated with almost identical N (inner shell) disorder as pangolin-CoV-2017 (N-PID (percentage of intrinsic disorder): 44.8% vs. 44.9%—lower than other variants). The outer shell disorder (M-PID) of Omicron is lower than that of other variants and pangolin-CoV-2017 (5.4% vs. 5.9%). COVID-19-related CoVs have the lowest M-PIDs (hardest outer shell) among all CoVs. This is likely to be …

Would New Sars-Cov-2 Variants Change The War Against Covid-19?, Elrashdy M. Redwan, Fatma Elrashdy, Alaa A.A. Aljabali, Wagner Baetas-Da-Cruz, Debmalya Barh, Adam M. Brufsky, Sk. Sarif Hassan, Kenneth Lundstrom, Ángel Serrano-Aroca, Kazuo Takayama, Murtaza M. Tambuwala, Bruce D. Uhal, Vladimir N. Uversky

Molecular Medicine Faculty Publications

The scientific, private, and industrial sectors use a wide variety of technological platforms available to achieve protection against SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2), including vaccines. However, the virus evolves continually into new highly virulent variants, which might overcome the protection provided by vaccines and may re-expose the population to infections. Mass vaccinations should be continued in combination with more or less mandatory non-pharmaceutical interventions. Therefore, the key questions to be answered are: (i) How to identify the primary and secondary infections of SARS-CoV-2? (ii) Why are neutralizing antibodies not long-lasting in both cases of natural infections and post-vaccinations? …

Bayesian Molecular Dating Analyses Combined With Mutational Profiling Suggest An Independent Origin And Evolution Of Sars-Cov-2 Omicron Ba.1 And Ba.2 Sub-Lineages, Naveen Kumar, Rahul Kaushik, Ashutosh Singh, Vladimir N. Uversky, Kam Y. J. Zhang, Upasana Sahu, Sandeep Bhatia, Aniket Sanyal

Molecular Medicine Faculty Publications

The ongoing evolution of severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) has resulted in the recent emergence of a highly divergent variant of concern (VOC) defined as Omicron or B.1.1.529. This VOC is of particular concern because it has the potential to evade most therapeutic antibodies and has undergone a sustained genetic evolution, resulting in the emergence of five distinct sub-lineages. However, the evolutionary dynamics of the initially identified Omicron BA.1 and BA.2 sub-lineages remain poorly understood. Herein, we combined Bayesian phylogenetic analysis, mutational profiling, and selection pressure analysis to track the virus’s genetic changes that drive the early evolutionary dynamics of …

Non-Verbal Communication, Anxiety, Behavioral Changes Within Covid Regulatory Changes, Sydney Stack, Olivia Mccracken

Communication Senior Capstones

In the current era of education and social communication shifting into a virtual world the students entering the early elementary education system have experienced something that is new to all of us. Within the last two and a half years life as we have known it has vastly shifted. Virtual learning and communication, which is not something that is new, but something that was scarce prior to the Covid-19 pandemic is now the “new normal.” For many of the students affected, this way of learning has shaped much of their educational career. Changes like these are affecting areas of development …

Yoga, Stress, And College Students During The Covid-19 Pandemic: A Mixed Methods Study, Lori Klein

West Chester University Doctoral Projects

College students have experienced exponential increases in stress and mental health concerns that continued to rise during the global coronavirus pandemic. Yoga is a popular, well-regarded method for improving psychological wellbeing, and this study explored how students’ perceived stress improved during a semester-long introductory yoga course upon returning to in-person instruction after a period of remote learning as a result of coronavirus restrictions. This study used an explanatory sequential mixed method design to first measure perceived stress scores and then compare this data to student-reports of wellbeing. College students (n = 121) enrolled in 8 sections of Yoga 1 completed …

The Pandemic Dilemma: A Mixed-Methods Study Of Student-Centered Science Education In The Covid-19 Pandemic, Jennifer Slavick

West Chester University Doctoral Projects

The purpose of this explanatory sequential mixed-methods study was to determine how student-centered instruction shifted and what dilemmas teachers experienced in enacting science instruction as they worked through the COVID-19 pandemic. A modified Draw-A-Science-Teacher-Test was used to examine teachers’ perceived instruction during the Fall of 2019, Fall of 2020, and Fall of 2021. Scores on this modified checklist were compared to determine differences in instruction year-to-year, across grade-bands, and to find trends in instruction concerning student demographics. Interviews were conducted with a subset of teachers in the study to learn more about the dilemmas they faced as their attempted science …

Trauma-Informed Educational Practices In The Middle School Classroom During The Covid-19 Pandemic, Loralynne Yost

West Chester University Doctoral Projects

This collective case study used a mixed methods approach to examine how Trauma-Informed Educational Practices (TIEP) manifest in the middle school classroom. This study is important due to the trauma students experienced during the COVID-19 pandemic. Teacher participants had district training in trauma-informed practices prior to this study.

Teacher participants took an initial survey to capture their conceptualization and perceived usage of the TIEP in the classroom. Teachers then used TIEP in their classrooms for two weeks. Teachers kept a checklist of which of the TIEP they used each day and commented on the context for the use of the …

Distance Education Under Duress: A Case Study Of Exchange Students’ Experience With Online Learning During The Covid-19 Pandemic In The Republic Of Korea, William H. Stewart, Patrick R. Lowenthal

Educational Technology Faculty Publications and Presentations

COVID-19 caused universities around the world to transition overnight to some type of remote learning or online format. The way this occurred, though necessary, was a departure from the standards and norms of traditional distance education and was a drastic change for the majority of faculty and students who had no prior experience with remote, blended, or online learning. This case study was conducted in the Republic of Korea with 15 international exchange students who found themselves forced to take distance education courses on an empty campus during the COVID19 pandemic. Themes of isolation and loneliness, diverse learning experiences, little-to-no …

Transportation Barriers To Care Among Frequent Health Care Users During The Covid Pandemic, Abigail L. Cochran, Noreen C. Mcdonald, Lauren Prunkl, Emma Vinella‑Brusher, Jueyu Wang, Lindsay Oluyede, Mary Wolfe

Community and Regional Planning Program: Faculty Scholarly and Creative Activity

Background: Transportation problems are known barriers to health care and can result in late arrivals and delayed or missed care. Groups already prone to greater social and economic disadvantage, including low-income individuals and people with chronic conditions, encounter more transportation barriers and experience greater negative health care consequences. Addressing transportation barriers is important not only for mitigating adverse health care outcomes among patients, but also for avoiding additional costs to the health care system. In this study, we investigate transportation barriers to accessing health care services during the COVID-19 pandemic among high-frequency health care users.

Methods: A web-based survey was …

School Provided Speech-Language Therapy Plans Amid The Coronavirus Pandemic And Correlating Provider Attitudes, Zabia Evans

OUR Journal: ODU Undergraduate Research Journal

As the Coronavirus pandemic continues to be a threat for those of all ages, schools were a main concern when discussing how we should attempt to return to our “normal” lives. A considerable amount of speech therapy is done in schools, and speech-language pathologists nationwide are also being impacted by the changes during this school year. This research examined many aspects of providing speech therapy during the 2020-2021 school year, beginning with introductory statistics concerning the number of children participating in each session, the instruction styles, and grade levels taught. Respondents answered a set of questions concerning their attitudes towards …

A Lost Generation: Perpetual Education Insecurity Among The Rohingya, Robin E. Al-Haddad, Kendra L. Duran, Saleh Ahmed

Global Studies Faculty Publications and Presentations

Education security exists when every child has equal access to quality education. Rohingya refugee children suffer widespread rates of education insecurity both in their home country, Myanmar and in their host country, Bangladesh. While the right to education is recognized in several human rights instruments, access to education is not ubiquitous, making the ability to achieve this right challenging for many Rohingya. Government restrictions on accredited education, COVID-19 related school closures, failures in launching a pilot of the Myanmar curriculum, and recent government plans to relocate refugees to Bhasan Char Island have created a ‘lost generation’ of Rohingya youth. This …

Using The Protection Motivation Theory To Understand The Mental Health Impact Of Surviving Covid-19, Kaprea Johnson, Angel Spence, Yousef Sherif, Dana Brookover, Adrienne White

Adultspan Journal

Due to the widespread effects of COVID-19, mental health professionals need to understand the lived experiences of survivors. Data were collected from YouTube videos (N = 52), which contained firsthand perspectives from COVID-19 survivors. Survivors understood the high stakes of COVID-19, reported the dual threat to physical and mental health, entered “survival mode,” and had both positive and negative reflections on the experience. Implications for mental health professionals and future research directions are included.

Outcomes Of Sars-Cov-2-Positive Youths Tested In Emergency Departments: The Global Pern-Covid-19 Study, Anna L. Funk, Fahd A. Ahmad, Et Al

Open Access Publications

Importance: Severe outcomes among youths with SARS-CoV-2 infections are poorly characterized.

Objective: To estimate the proportion of children with severe outcomes within 14 days of testing positive for SARS-CoV-2 in an emergency department (ED).

Design, Setting, and Participants: This prospective cohort study with 14-day follow-up enrolled participants between March 2020 and June 2021. Participants were youths aged younger than 18 years who were tested for SARS-CoV-2 infection at one of 41 EDs across 10 countries including Argentina, Australia, Canada, Costa Rica, Italy, New Zealand, Paraguay, Singapore, Spain, and the United States. Statistical analysis was performed from September to October 2021. …

Advances And Gaps In Sars-Cov-2 Infection Models, César Muñoz-Fontela, Michael S. Diamond, Et Al

Open Access Publications

The global response to Coronavirus Disease 2019 (COVID-19) is now facing new challenges such as vaccine inequity and the emergence of SARS-CoV-2 variants of concern (VOCs). Preclinical models of disease, in particular animal models, are essential to investigate VOC pathogenesis, vaccine correlates of protection and postexposure therapies. Here, we provide an update from the World Health Organization (WHO) COVID-19 modeling expert group (WHO-COM) assembled by WHO, regarding advances in preclinical models. In particular, we discuss how animal model research is playing a key role to evaluate VOC virulence, transmission and immune escape, and how animal models are being refined to …

Perceptions Of Risk Of Sars-Cov-2 Transmission In Social And Educational Activities By Infectious Diseases And General Pediatric Healthcare Providers, A Pre-Vaccine Risk Perception Cross-Sectional Survey, Andrew B. Janowski, Philip M. Polgreen, Susan E. Beekmann, Jason G. Newland

Open Access Publications

BACKGROUND: The perception of the transmission risks of SARS-CoV-2 in social and educational settings by US healthcare providers have not been previously quantified.

METHODS: Respondents completed an online survey between September and October 2020 to estimate the risk of SARS-CoV-2 transmission on a scale of 0-10 for different social and educational activities prior to the availability of the SARS-CoV-2 vaccines. Demographic information and experiences during the pandemic were also collected. The risk assessment was emailed to three listservs of healthcare providers, including national listservs of pediatric (PID) and adult infectious diseases (AID) providers, and a listserv of general pediatric practitioners …

Ethical, Regulatory, And Practical Barriers To Covid-19 Research: A Stakeholder-Informed Inventory Of Concerns, Bryan A. Sisk, Kari Baldwin, Meredith Parsons, James M. Dubois

Open Access Publications

INTRODUCTION: SARS-CoV-2 (COVID-19) has caused death and economic injury around the globe. The urgent need for COVID-19 research created new ethical, regulatory, and practical challenges. The next public health emergency could be worse than COVID-19. We must learn about these challenges from the experiences of researchers and Research Ethics Committee professionals responsible for these COVID-19 studies to prepare for the next emergency.

MATERIALS AND METHODS: We conducted an online survey to identify the ethical, oversight, and regulatory challenges of conducting COVID-19 research during the early pandemic, and proposed solutions for overcoming these barriers. Using criterion-based, convenience sampling, we invited researchers …