Digital Commons Network^™

An Intranasal Subunit Vaccine Induces Protective Systemic And Mucosal Antibody Immunity Against Respiratory Viruses In Mouse Models., Aina Karen Anthi, Anette Kolderup, Eline Benno Vaage, Malin Bern, Sopisa Benjakul, Elias Tjärnhage, Fulgencio Ruso-Julve, Kjell-Rune Jensen, Heidrun Elisabeth Lode, Marina Vaysburd, Jeannette Nilsen, Marie Leangen Herigstad, Siri Aastedatter Sakya, Lisa Tietze, Diego Pilati, Mari Nyquist-Andersen, Mirjam Dürkoop, Torleif Tollefsrud Gjølberg, Linghang Peng, Stian Foss, Morten C Moe, Benjamin E. Low, Michael V. Wiles, David Nemazee, Frode L Jahnsen, John Torgils Vaage, Kenneth A Howard, Inger Sandlie, Leo C James, Gunnveig Grødeland, Fridtjof Lund-Johansen, Jan Terje Andersen

Faculty Research 2025

Although vaccines are usually given intramuscularly, the intranasal delivery route may lead to better mucosal protection and limit the spread of respiratory virus while easing administration and improving vaccine acceptance. The challenge, however, is to achieve delivery across the selective epithelial cell barrier. Here we report on a subunit vaccine platform, in which the antigen is genetically fused to albumin to facilitate FcRn-mediated transport across the mucosal barrier in the presence of adjuvant. Intranasal delivery in conventional and transgenic mouse models induces both systemic and mucosal antigen-specific antibody responses that protect against challenge with SARS-CoV-2 or influenza A. When benchmarked …

Mental Health Crisis Of Medical Staffs During The Pandemic – How Has The Covid-19 Impacted Health Care Workers’ Mental Status, Yue Chen

Rowan-Virtua Research Day

The COVID-19 pandemic has waged a relentless battle against humanity, but amidst the physical toll lies a hidden front: the war on the mental health of our healthcare workers (HCWs).

Previous reviews have demonstrated a potential prevalence of mental health problems among HCWs, but these reviews necessitate updating and inclusion of more studies, along with a comparative analysis of pre- and post-pandemic backgrounds. Therefore, the aim of my study is to deliver updated prevalence estimates for mental health concerns among HCWs in the aftermath of the COVID-19 pandemic.

The results show not only a drastic increase in the percentage of …

Is Increased Screen Time Associated With A Higher Prevalence Of Myopia In Elementary-Aged Children Globally?​, Katerina Kasatkin, Sree Gowri Sudharshan, Lakumi Dias, Adira Brenner, Emily Reilly, Maikel Mansour

Rowan-Virtua Research Day

Background: The onset of myopia in children has emerged as a significant public health concern, especially with increased screen time and reduced outdoor activity following the COVID-19 pandemic. The global prevalence of myopia is expected to rise significantly, with children being particularly vulnerable. Various studies have explored how screen time, near-work activities, and outdoor exposure influence the increasing prevalence of myopia in pediatric populations worldwide.

Hypothesis: This paper aims to evaluate whether increased screen time, especially following the COVID-19 pandemic, is associated with a higher prevalence of myopia in young children, providing a more robust understanding of this relationship across …

Assessing The Impact Of The Covid-19 Pandemic On Health Literacy In Patients Presenting To A Student-Run Free Clinic, Sabah Iqbal, Kirsten Carlberg, Krisha S. Patel, Ashlyn Mcclelland, Sarah Marotta, Rebecca Moore

Rowan-Virtua Research Day

Background

Health literacy as defined by the Center for Disease Control and Prevention (CDC), refers to an individual’s ability to find, understand, and use health information and services1. This definition has evolved with the onset of the COVID-19 pandemic and increasing emphasis on preventative healthcare. We aimed to observe the impact of the pandemic on the health literacy of patients in a free community clinic run by medical students.

Hypothesis

This study aims to assess the effect of various demographic and socioeconomic factors and the COVID-19 pandemic on health literacy levels estimated by the NVS assessment in the patient population …

Identifying Barriers To Covid-19 Vaccination In Hispanic Populations, Saul O. Castillo, Kurt R. Wharton

Posters

Vaccination hesitancy has always been an issue within marginalized communities. This is why it came as no surprise when the COVID-19 vaccine was met with resistance upon its release1. However, it has been many years since the FDA approved the first COVID19 vaccine and on some level, COVID-19 has become a part of our daily lives. This means that people have had time to determine how they feel about the COVID19 vaccine and reflect on their decisions to receive or decline the vaccine.

There are many reasons as to why people choose to receive or decline the COVID-19 vaccine. This …

Assessing The Impact Of The Covid-19 Pandemic On Mental Health In Patients Presenting To A Student-Run Free Clinic, Sabah Iqbal, Kirsten Carlberg, Emily Reilly, Jessica Ivanov, Victoria Youssef, Lily Roessler, Maikel Monsour, Nils Brolis

Rowan-Virtua Research Day

Background

Mental health is an important part of patient care, therefore it is imperative to understand how it’s recognized and treated. Socioeconomic status and the COVID19 pandemic contribute to disproportionate incidences of mental illness^{1, 2, 10, 11, 12}. This study uses data from a student-run clinic, the Rowan-Virtua Community Health Center (RVCHC), to examine disparities in mental health needs and screenings among the local population.

Hypothesis

It was hypothesized that underserved populations are at a disadvantage when it comes to both mental health screenings and treatment due to restricted access to healthcare and other unmet needs. Additionally, the …

Risk Communication And Public Health Emergency Responses During Covid-19 Pandemic In Rural Communities In Kenya: A Cross-Sectional Study, Wilberforce Cholo, Fletcher J. Njororai, Walter Ogutu Amulla, Caleb Kogutu Nyaranga

Population Health Leadership and Analytics Faculty Publications and Presentations

Background: The COVID-19 pandemic highlighted the crucial role of community preventive behaviors in controlling the virus’ spread. Studies show that people’s risk perceptions and awareness significantly contribute to the containment and prevention of infections by motivating adoption of desired actions and behaviors. This study aimed at assessing the role of risk communication and factors that influenced responses during the COVID-19 pandemic in rural communities in Western Kenya. Methods: A descriptive cross-sectional study was conducted using a quantitative research approach, collecting data from 806 individuals across Kisumu, Vihiga, and Kakamega counties. Descriptive statistics were used to detail the demographic characteristics of …

The Impact Of The Covid-19 Pandemic On The Curriculum Orientations Of High School Teachers, Matthew G. Howard

Education Doctorate Dissertations

Teacher beliefs, particularly about the aims of education, impact what they teach, how they teach, and how they assess learning. Understanding how those beliefs were impacted by the COVID-19 pandemic offers insights about COVID’s long-term influence on education. This cross-sectional quantitative study utilized Eisner and Vallance’s (1974) curriculum orientations framework to examine the beliefs of high school teachers, as well as their perceived changes in belief after the pandemic. The study utilized the previously validated Survey of Curriculum Orientations (SCO) as an instrument. A total of 305 high school teachers from a large school district in a major metropolitan area …

The Impact Of Covid-19 During The First Two Years: Giving Voice To Pediatric Nurses, Karen S. Gralton, Kathryn J. Malin, Eileen Sherburne, Danielle Smith, Stacy Wenner, Julie Averbeck, Amy Newman, Anita Norton, Genesee Hornung, Karen Kavanaugh

College of Nursing Faculty Research and Publications

Purpose

The purpose of this study was to describe the experiences of pediatric nurses providing direct care in a variety of settings during the first two years of the COVID-19 pandemic.

Design and methods

This was a qualitative descriptive study. Donabedian's Quality Framework for the Evaluation of Healthcare was used to guide the design. Purposive sampling was used to recruit 24 direct care nurses from inpatient and outpatient settings within one healthcare system. Semi-structured, audio-recorded interviews were conducted in-person or via a virtual platform from November 2021 through March 2022.

Results

Four major themes were determined across all settings and …

The Uneven Disruptions Covid-19 Caused To Scholars’ Publication: A Preregistered Study, Marco De Prosperis

Graduate Theses and Dissertations

This proposed, preregistered study investigates the uneven impacts of COVID-19 on scholarly productivity among University of Arkansas faculty, focusing on how demographic and professional factors—such as gender, ethnicity, academic rank, tenure status, field of study, and the presence of children—may have moderated productivity during the pandemic. Utilizing a non-experimental, cross-sectional design, this research will collect data from 160 full-time faculty members through an online survey. Grounded in Role Theory, the study will examine role conflict and enrichment as faculty navigated shifting responsibilities in research, teaching, and caregiving during remote work. This study is particularly relevant as many assistant professors who …

Emotion Analysis And Topic Modelling Of Supply Chain Discussion During The Covid-19 Pandemic, Suhong Li, Fang Chen, Thomas Ngniatedema

American Business Review

This study aims to investigate the supply chain discussion during the COVID-19 pandemic using the supply chain tweets collected between March 2020 and May 2022 globally. The findings reveal an evolving sentiment trajectory: while the users’ sentiment remained neutral in 2020 and 2021, a negative sentiment surged starting in January 2022. Moreover, an emotion analysis indicates a mix of sadness and optimism among Twitter users, with anger gradually intensifying from June 2021 onward. Furthermore, topic modeling reveals distinct themes discussed each year. In 2020, major topics centered around the government’s response to COVID-19, food and medical supply chain crises. By …

Administrative Law And The Pandemic, Gillian E. Metzger

Faculty Scholarship

American administrative law’s relationship to change is, as they say, compli­cated. On the one hand, continual evolution has been an endemic feature of American administrative law. Doctrines such as Chevron deference to agency statutory interpretations were born, grew, and declined in just the period from the 1980s to today. On the other, the United States (US) Supreme Court regularly rejects such common law development in administrative law as illegitimate and insists that federal judges must adhere to the original terms of the 1946 Administrative Procedure Act (APA) and other statutes, unless the Constitution requires otherwise. And to this day scholars …

Working To Death: Labor Law In The 100 Year Life, Kate Andrias

Faculty Scholarship

Without significant changes in labor law, the 100-year life will almost certainly be defined by deep inequities. Working-class people, and workers of color in particular, are least likely to enjoy extended life spans. And if they do live longer, they are unlikely to enjoy a leisurely retirement in which they decide how they spend their extra years. Instead, they will face more toil and precarity. This chapter imagines a different future. It asks: What would the 100-year life look like if working people had a greater hand in shaping it? What would a legal regime look like that gave working …

In Silico Evaluation Of Bisphosphonates Identifies Leading Candidates For Sars-Cov-2 Rdrp Inhibition, Mohammed Muzaffar-Ur-Rehman, Kishor Suryakant Chougule, Ala Chandu, Pranali Vijaykumar Kuthe, Mohit Garg, Murugesan Sankaranarayanan, Seshadri S. Vasan

Research outputs 2022 to 2026

The novel coronavirus disease (COVID-19) pandemic has resulted in 777 million confirmed cases and over 7 million deaths worldwide, with insufficient treatment options. Innumerable efforts are being made around the world for faster identification of therapeutic agents to treat the deadly disease. Post Acute Sequelae of SARS-CoV-2 infection or COVID-19 (PASC), also called Long COVID, is still being understood and lacks treatment options as well. A growing list of drugs are being suggested by various in silico, in vitro and ex vivo models, however currently only two treatment options are widely used: the RNA-dependent RNA polymerase (RdRp) inhibitor remdesivir, and …

The Switch: Determinants Of Family School Modality Choices During The Covid-19 Pandemic, Steicy Dorfi Lopez

Economics Undergraduate Honors Theses

The K-12 system in the United States experienced substantial challenges during the COVID-19 pandemic. This study aims to give an overview of public, private, and homeschooling enrollment decisions during the pandemic, the changes families made between types of schooling and identify familial characteristics associated with the probability of switching in and out of public education. Knowing more about the groups exiting and returning to the public school system can help public school districts better tailor policies to attract and retain their students. Socioeconomic factors influencing a change could be signs of increasing segregation. Using a discrete choice duration model, a …

Motivations And Goals For Combatting Covid-19 Misinformation In Clinical Setting: A Case Study Of Nursing Students., Amarachi H. Okoronkwo

All Theses

The misinformation surrounding COVID-19 disrupted public health efforts to mitigate the virus. This study examined the motivations and goals of nursing students to combat COVID-19 misinformation within clinical settings. Medical professionals are best suited to combat health misinformation due to their expertise and lived experience, but they are not mandated but encouraged to address COVID-19 misinformation. Grounded in qualitative research methods and grounded theory, semi-structured interviews were conducted with nursing students who have had clinical practice after the start of the COVID-19 pandemic. Findings reveal that the key motivations and goals for addressing misinformation include the need to educate patients, …

School Counselors’ Lived Experiences During The Covid-19 Pandemic, Katie M. Guzman Dunn

Doctoral Dissertations and Projects

The purpose of this phenomenological study was to understand how school counselor perceptions of their roles may have been permanently impacted by the COVID-19 pandemic. Bronfenbrenner’s (1979) Ecological Systems Theory, which relates to the interactions of an individual and the environment around them, guided the study. The study’s central research was: What are public school counselors’ lived experiences regarding their role perception during the COVID-19 pandemic? Data was collected through virtual semi-structured interviews and photo elicitation with 10 school counselors who were members of the Kentucky School Counselor Association. The data collected from the interviews was analyzed using bracketing to …

The Burden Of Care: A Phenomenological Inquiry Into The Lived Experiences Of Homeless Shelter Administrators Leading Through The Pandemic And Lasting Implications On Program Operations, Marie Adele Wilson

Doctoral Dissertations and Projects

The theories guiding this study are Maslow's Hierarchy of Needs, conflict theory, and complex systems theory, which explain the relationship between the theory and resource limitations and acquisition, systems, and nature of acquiring human needs. The purpose of this phenomenological study is to describe homeless shelter administrators'/directors' experiences delivering services during the COVID-19 pandemic on the Eastern Coast of the United States and Texas. It further seeks to unravel how the pandemic informed the delivery of services and program administration related to homeless shelters and its impacts. The research questions sought to understand the impact of COVID-19 on delivering services …

Leadership Post Covid-19: Exploring The Lived Experiences Of Public-School Administrators And Support Through Professional Development, Teresa Marie Burr

Electronic Theses, Projects, and Dissertations

This qualitative study aimed to gather knowledge from the lived experiences of public school administrators before, during, and after the COVID-19 pandemic. Questions focused on the support and training received, experiences at school sites and online, and the lessons learned during this time. The literature review focused on issues that school administrators dealt with during this time. Challenges were varied, and solutions and information provided from the review indicated the need for communication, support, and planning. The theoretical framework was Activity Theory and Cultural Historical Activity Theory, which focused on the premise that an activity may be shared and taken …

Demographic Groups’ Use Of Agency Intimate Partner Violence (Ipv) Services: A Quality Improvement Project To Identify And Engage Local Underserved Populations, Mia Parker

Capstone Experience: Master of Public Health

This quality improvement project intended to identify populations of adult intimate partner violence (IPV) survivors in Spokane County, Washington, by race/ethnicity and sex who are underserved by a local victim service agency and provide action-oriented, evidence-informed recommendations that the agency may utilize to increase engagement with these local underserved populations. Methods used include secondary data analysis, timeline creation, literature review, and interpretation of quantitative and qualitative data analysis. This was a capstone project designed to demonstrate multiple public health competencies.

The Kids Aren’T Alright: Changes In The Mental Health Of Adolescents Post-Covid-19, Tanya Belom

Education (PhD) Dissertations

Mental health is an increasing concern for today’s youth, with one in six U.S. children and adolescents aged 6-17 experiencing a mental health disorder each year, and 50% of all lifetime mental illnesses begin by age 14. The COVID-19 pandemic, which resulted in lockdowns, social isolation, school closures, and ultimately a disruption in everyday life, is believed to have adversely impacted the mental health of children and adolescents. There is limited research available on the impacts of the pandemic on adults, and even less research is available on the impact of the pandemic on youth, specifically as we navigate the …

From Epithelium To Therapy: Transitional Cells In Lung Fibrosis, Sarah Y Shin, Jichao Chen, Irit Milman Krentsis, Yair Reisner, Rodeo Abrencillo, Rahat Hussain, Danielle Wu, Harry Karmouty-Quintana

Faculty, Staff and Student Publications

Patients with idiopathic pulmonary fibrosis and lung fibrosis secondary to infections such as influenza A and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have limited treatment options outside of supportive therapy and lung transplantation. Multiple lung stem cell populations have been implicated in the pathogenesis of lung fibrosis, and more progenitor cell populations continue to be discovered and characterized. In this review, we summarize the functions and differentiation pathways of various cells that constitute the lung epithelium. We then focus on two subpopulations of KRT5

Positive And Negative Religious Coping As A Moderator Of The Relationship Between Covid-19 Stressors And Employee Burnout Among Vocational Rehabilitation Counselors, Kristen M. Lewis

Doctoral Dissertations and Projects

During the investigation of this study, no study was located that explores the moderating effects of both positive religious coping (PRC) and negative religious coping (NRC) on the COVID-19 stressor-employee burnout relationship within the vocational rehabilitation counseling (VRCs) profession. Therefore, this study sought out to examine just that. Recruitment emails were sent out to VRCs to obtain 79 participants who were at least 18 years old, have worked at least 6 months as a VRC during the COVID-19 pandemic, and worked an average of 20 hrs/week. Each participant completed a 20-minute online survey containing CIS, PSS, MBI-HSS, Brief RCOPE scales. …

Contagions Of Doubt: Denialism And The Spread Of Medical Conspiracy Theories, Haley Boom

Anthropology

Denialism and conspiratorial thinking have long shaped public perceptions of science and medicine, but the COVID-19 pandemic exposed how rapidly these forces can evolve and spread in a digital age. This thesis examines the historical roots, psychological foundations, and modern amplification of medical conspiracy theories, with a particular focus on vaccine skepticism and COVID-19-related misinformation. As a literature review, it synthesizes existing interdisciplinary research from psychology, public health, and communication studies to explore how medical conspiracy beliefs emerge from complex interactions between cognitive biases, emotional needs, mistrust in institutions, and evolving media environments. The rise of social media, political polarization, …

An Exploration Of Substance Abuse By Healthcare Workers During The Covid-19 Pandemic: A Scoping Review, Andrew Hills

Capstone Experience: Master of Public Health

Objective

This scoping review aims to identify available literature and research on substance abuse by healthcare workers (HCWs) during the COVID-19 pandemic to examine whether the stress of their duties during the pandemic exacerbated existing issues of substance abuse.

Methods

A literature search using PubMed and Google Scholar using Harzing Publish or Perish identified 100 relevant professionally-authored, peer-reviewed, English-language academic articles published between 2015 and 2025 on substance abuse by HCWs. Exclusions were done via a review of the abstract and then from the full text, reducing the number of articles to three from those three articles which generated an …

Evaluating The Test-Negative Design For Covid-19 Vaccine Effectiveness Using Randomized Trial Data: A Secondary Cross-Protocol Analysis Of 5 Randomized Clinical Trials, Leah I B Andrews, M Elizabeth Halloran, Kathleen M Neuzil, Lars Van Der Laan, Yunda Huang, Jessica Andriesen, Mayur Patel, Leigh H Fisher, Holly Janes, Nadine Rouphael, Stephen R Walsh, Deborah A Theodore, Hong-Van Tieu, Magdalena Sobieszczyk, Hana M El Sahly, Lindsey R Baden, Ann R Falsey, Thomas B Campbell, Colleen F Kelley, Catherine Mary Healy, Lilly Immergluck, Benjamin Luft, Ian Hirsch, Guy De Bruyn, Carla Truyers, Frances Priddy, Kelsey M Sumner, Brendan Flannery, Dean Follmann, Peter B Gilbert, Covid-19 Prevention Network (Covpn)

Faculty, Staff and Students Publications

Importance: The test-negative design (TND) has been widely used to assess postmarketing COVID-19 vaccine effectiveness but requires further evaluation for this application.

Objective: To determine whether the TND reliably evaluates vaccine effectiveness against symptomatic COVID-19 using placebo-controlled vaccine efficacy randomized clinical trials (RCTs).

Design, setting, and participants: This secondary cross-protocol analysis constructed TND study datasets from study sites in 16 countries across 5 continents using the blinded phase cohorts of 5 harmonized phase 3 COVID-19 Prevention Network RCTs: COVE (Coronavirus Vaccine Efficacy and Safety), AZD1222, ENSEMBLE, PREVENT-19 (Prefusion Protein Subunit Vaccine Efficacy Novavax Trial COVID-19), and VAT00008. Participants included adults …

The Effects Of The Covid-19 Pandemic On Transit In The San Francisco Bay Area, Richard W. Lee, David B. Reinke, Christopher E. Ferrell, Charles Rivasplata, John M. Eells, Luana Chen

Mineta Transportation Institute

This report presents the findings from our study for the California State Assembly Transportation Committee on the effects of the COVID-19 pandemic on Bay Area Transit. The study consisted of a review of the literature on the effects of the pandemic on transit in the US, a detailed look at changes in ridership and economics for Bay Area transit agencies, comparisons of Bay Area transit ridership changes to those in similar US metropolitan areas, and analysis of possible remedies to restore the financial health of Bay Area transit agencies. Bay Area transit ridership has recovered somewhat from the depths of …

Sensitivity Of Lung Point-Of-Care Ultrasound (Pocus) To Predict Oxygen Requirements In Emerging Viral Infections, Daniel L Theodoro, Di Coneybeare, Penelope Lema, Nicholas Renz, Laura Wallace, Enyo Ablordeppey, Sean Stickles, Alek Rosenthal, Ian Holley, Sirivalli Chamarti, Josie Acuña, James Patterson, Rachel Ancona, Srikar Adhikari

2020-Current year OA Pubs

OBJECTIVES: The prognostic characteristics of lung point-of-care ultrasound (L-POCUS) to predict respiratory decompensation in patients with emerging infections remains unstudied. Our objective was to examine whether scored lung ultrasounds predict hypoxia among a nonhypoxic, ambulatory population of patients with COVID-19.

METHODS: This was a diagnostic case-control study. Three academic emergency departments across the United States collected a convenience sample of nonhypoxic subjects with COVID-19, scored subjects' hemithorax at 7 locations using lung ultrasound, and followed outcomes for 40 days. We defined cases as hypoxia (≤91% by pulse oxygenation) from 2 hours after index presentation to day 40. Follow-up was by …

Maternal Drinking, Stress And Use Of Aggressive Parenting Over The Course Of The Covid-19 Pandemic, Jennifer Price Wolf, Bridget Freisthler

Faculty Research, Scholarly, and Creative Activity

Aims: The COVID-19 pandemic had a demonstrated impact on parenting but little is known about how parental drinking, stress, and use of aggressive discipline (a parenting behavior associated with abusive parenting and negative outcomes for children) have changed over time. We examine rates of alcohol use, stress, and aggressive discipline at three time points during the COVID-19 pandemic and investigate what maternal, child, and time-varying factors predict weekly use of aggressive parenting. Methods: We use longitudinal data from the Central Ohio Family Study (COFLS), including women (n = 234) with a child between the ages of 0–12 and recruited via …

The Effects Of A Two-Way Dual Language Program On The Educational Trajectory Of Hispanic Emergent Bilingual Students During The Impact Of The Covid-19 Pandemic: A Mixed-Methods Study, Jesus Jacob Villa

Open Access Theses & Dissertations

This explanatory mixed-methods study examines the impact of Dual Language Bilingual Education (DLBE) and Transitional Bilingual Education (TBE) programs on the academic achievement of Hispanic emergent bilingual students during and after the COVID-19 pandemic. With the U.S. Hispanic student population growing significantly, and emergent bilingual students historically underserved, this study addresses critical gaps in educational equity. Conducted in two school districts along the U.S. and Mexico border in Texas and New Mexico, the research explores how DLBE and TBE programs mitigated the pandemic's adverse effects on learning. This study analyzed quantitative data from standardized mathematics and language proficiency assessments for …