Digital Commons Network^™

Sars-Cov-2 Nsp13 Interacts With Tead To Suppress Hippo-Yap Signaling, Fansen Meng, Jong Hwan Kim, Chang-Ru Tsai, Jeffrey D Steimle, Jun Wang, Yufeng Shi, Rich G Li, Bing Xie, Vaibhav Deshmukh, Shijie Liu, Xiao Li, James F Martin

Faculty, Staff and Students Publications

The Hippo pathway controls organ development, homeostasis, and regeneration primarily by modulating YAP/TEAD-mediated gene expression. Although emerging studies report Hippo-YAP dysfunction after viral infection, it is largely unknown in the context of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Here, we analyzed RNA sequencing data from human-induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) and SARS-CoV-2-infected human lung samples, and observed a decrease in YAP target gene expression. In screening SARS-CoV-2 nonstructural proteins, we found that nonstructural protein 13 (NSP13), a conserved coronavirus helicase, inhibits YAP transcriptional activity independent of the upstream Hippo kinases LATS1/2. Consistently, introducing NSP13 into mouse cardiomyocytes suppresses …

The Lingering Effects Of The Covid-19 Pandemic On Nurses, Linda H. Yoder, Jacqueline M. Gordon, Noah Zanville

International Nursing Research Congress (INRC)

Background: Posttraumatic growth (PTG) is the experience of positive psychological change after struggling with major life crises, often resulting in a re-evaluation of priorities, greater appreciation for life, and spiritual/existential growth. The purpose of this national study was to measure PTG levels among nurses caring for patients during the ongoing COVID-19 pandemic.

Design: The survey study consisted of 2,077 U.S. based Academy of Medical-Surgical Nurses (AMSN) members and nurses from 23 hospitals in HCA Healthcare. The Posttraumatic Growth Inventory-Expanded (PTGI-X) and a demographic data collection sheet were used to collect data. Descriptive statistics and reliability testing were performed, as well …

Unvaccinated By Doubt: How Covid-19 Governance Sparked A Measles Outbreak, Ellen Black

Law Faculty Scholarship

This Article examines how the erosion of public trust in government and public health institutions during the COVID-19 pandemic has contributed to the resurgence of measles in the United States. It argues that pandemic-era governance—marked by inconsistent scientific messaging, politically charged public health mandates, and the federal government’s coordination with social media platforms to suppress dissenting viewpoints—generated widespread skepticism that continues to undermine vaccination uptake. Through a detailed analysis of lockdown policies, vaccine and mask mandates, and the subsequent revelations regarding governmental influence over online content moderation, the Article demonstrates how conflicting guidance and perceived censorship fostered long-lasting public doubt. …

The Experience Of A Medicalized Hotel Due To Covid-19, Ariadna Barta, Marta Cervera, Joan Escarrabill, Eva Palou, Anna Carbonell, Georgia Narsavage, Faust Feu, Carmen Hernandez

International Nursing Research Congress (INRC)

The emerging pandemic⁽¹⁾ caused by the rapid spread of the new coronavirus Covid-19 required urgent reorganization to respond to care demands of patients with this new disease^(2-4). In Spain, nurses were key contributors to providing out of hospital care. Transforming a hotel into a medical setting was an innovative idea that was able to provide integrated nursing and quality health care for patients recovering from Covid-19^(5,8,9).

Purpose: To examine the experiences and perceived care of patients admitted to a Medicalized Hotel (MH) for Covid-19, from March 25 and May 15, 2020, by asking them …

Adaptive Ensemble Approaches For Face Mask Detection Using Transfer Learning Model, Faisal Alshanketi

University of Bisha Journal for Basic and Applied Sciences

Amidst the Covid-19 pandemic, wearing a mask has become mandatory and remains crucial in the ongoing pandemic. In certain situations and conditions, masks may be required periodically. However, manually monitoring large crowds of people to ensure they are wearing masks in public places or events can be an arduous task that is both time-consuming and difficult to manage. One way to address the challenge of manually monitoring mask-wearing in public places is to adopt machine learning (ML) methods and ICT-based surveillance mechanisms, thereby reducing the need for large numbers of personnel. While previous studies have proposed various machine learning models …

Comparing Regulation With Collective Bargaining: Drawing On Processes Of Change During The Covid-19 Crisis In Israel, Lilach Lurie, Guy Mundlak

Comparative Labor Law & Policy Journal

This article compares two systems of labour market governance: regulation by means of employment standards, and norms that are established in collective bargaining. A comparative framework draws nine criteria, spanning procedural and substantive dimensions, and emphasises the degree of integration between the systems, or “coupling.” The study uses Israel’s response to the COVID-19 crisis as a case study, drawing on a unique dataset of all regulatory provisions and collective agreements concluded from March 2020 to December 2021, supplemented by interviews with key actors. In the public sector, strong coupling was achieved through coordinated regulatory and bargaining processes, resulting in more …

Impact Of Covid-19 On Selected Nurse And Patient Outcomes In Emergency Units Across South Africa, Annette Lucia Pienaar, Siedine Knobloch Coetzee, Alwiena Johanna Blignaut, Marcel Fladimar Mather, Erika Fourie

International Nursing Research Congress (INRC)

There is extensive research on nurse outcomes^1-6 and nurse-reported patient outcomes^7-11 before, during, and after the COVID-19 outbreak . However, there is a notable absence of studies that examine such outcomes in emergency units across South Africa. It is evident that emergency nurses often experience the most adverse nurse outcomes, and the COVID-19 pandemic has exacerbated these negative impacts on emergency nurse outcomes^12-15. Not only is there a scarcity of studies examining the effects of the COVID-19 pandemic on nurse outcomes and nurse-reported patient outcomes in general in South Africa, but minimal research has been conducted …

The Economic Burden Of Covid-19 In A Region With Stringent Response Measures: A Case Study Of Taiwan, Elise Chia-Hui Tan, Fei-Yuan Hsiao, Ming-Chin Yang

Journal of Food and Drug Analysis

The COVID-19 pandemic has imposed a significant economic burden globally, particularly in regions with stringentresponse measures. This study aimed to assess the economic impact of COVID-19 in Taiwan, focusing on both directand indirect costs. A cost-of-illness analysis was conducted, utilizing data from the Taiwan Centers for Disease Control(CDC), national databases, epidemiological studies, and economic surveys. The analysis included both direct costs (e.g.,hospital admissions, outpatient care) and indirect costs (e.g., productivity losses due to long COVID, absenteeism, caregiving duties). The study encompassed Taiwan's population of 23.2 million, with particular attention to age-specific impacts on economic outcomes. The total economic burden of …

Predictors For Different Levels Of Covid-19 Vaccination Among Immigrant And Non-Immigrant Adults, Cheryl Zlotnick, Orit Cohen Castel

International Nursing Research Congress (INRC)

Overview: This study contributes to the literature by examining a comprehensive operationalization of vaccination status among working-age (21-49 years), immigrant and non-immigrant adults.

Background: The commonly used outcome, obtained any vaccination versus not, tends to overestimate COVID-19 vaccination utilization, distorting the associations found with covariates/predictors. More recent studies have used a three-variable COVID-19 status outcome of any, partial or complete vaccinations. However, they lacked a theoretical framework and focused on older and non-immigrant populations. This study examined working-age immigrants and non-immigrants, used the three-variable operationalization of COVID-19 vaccination, and was guided by Andersen’s Behavioral Model with its three factors …

The Lmpact Of The Covid-19 Pandemic On Registered Nurses, Mary Ellen Roberts, Joyce M. Knestrick, Lenore Resick

International Nursing Research Congress (INRC)

Background: The Covid –19 pandemic is a new experience with a substantial impact on the health and well-being of nurses caring for the patients diagnosed with the disease. Increased work and family demands have not been studied in these frontline workers. COVID-19 has altered many US nurses’ career plans. Over the past two years, the researchers have spoken with nurses who consistently, and increasingly, report planning to leave the workforce. This study looks at the impact of COVID-19 on the professional and personal lives of nurses.

Purpose: To understand the effects of COVID-19 a global pandemic on nurses caring for …

Nurses’ Lived Experiences During The Covid-19 Pandemic: A Descriptive Phenomenological Study, Kala Mayer, Jo Anne Bennett, Elizabeth Reifsnider, Jeanie Skibiski, Soojung Jo

International Nursing Research Congress (INRC)

The COVID-19 pandemic presented unprecedented challenges for nurses, including confronting end-of-life decisions, witnessing patient suffering, and burnout. Nevertheless, many nurses demonstrated resilience and personal growth despite adversities. Notable gaps in the literature include limited exploration of the long-term impacts of the pandemic on nurses, variations in experiences based on geographic, gender, and cultural factors, as well as the role of leadership and organizational response. Likewise, how nurses adapted to innovations such as new technologies and the impact of their pandemic experiences on patient outcomes and care quality remain underexplored. This study employed a phenomenological descriptive approach to capture nurses’ lived …

Factors Affecting Work Productivity Loss During The Covid-19 Pandemic: A Meta-Correlation Analysis, Jiyeon Jung, Inhae Cho, Jihyun Moon

International Nursing Research Congress (INRC)

Backgrounds: The COVID-19 pandemic has caused a decline in work productivity across various sectors. Identifying the factors influencing the loss of work productivity during a pandemic can have significant implications for health promotion and management among workers.

Objectives: This study aims to evaluate work productivity loss (including absenteeism and presenteeism) among workers during the COVID-19 pandemic by analyzing potential risk factors, such as demographic, individual, psychosocial, and organizational factors.

Design: We conducted a systematic review and meta-correlation analysis to identify risk factors influencing work productivity loss during the COVID-19 pandemic.

Review methods: Data were comprehensively searched across …

Exploring Cultural Dimensions Of Nurses' Experiences During Covid-19 In The Us And Hungary, Kala Mayer, Judit Staller, Jo Anne Bennett, Zoltán Balogh, Jeanie Skibiski, Anna Jeney, Soojung Jo, Elizabeth Reifsnider

International Nursing Research Congress (INRC)

Both the Hungarian and U.S. public health and care systems were inadequately prepared to manage the COVID-19 pandemic, contributing to significant distress among nurses. The role of geographical, gender, and cultural factors, along with leadership and organizational response during the pandemic between countries, remains underexplored in the literature. Nurses around the world are now more likely than before the pandemic to leave direct patient care roles. Cultural influences and healthcare system structure play crucial roles in shaping nurses' decisions to stay in or leave the profession. To address this research gap, we are using the lens of Hofstede’s Cultural Dimensions …

Corporate Social Responsibility Disclosure And Financial Performance: Empirical Evidence From Vietnam, Nguyen T. Tran, Nhung T. Le, Tung D. Nguyen

Economic and Business Review

This study examines the relationship between corporate social responsibility (CSR) disclosure and firm performance, with particular attention to CSR's role as a mitigating mechanism during periods of economic crisis, notably the COVID-19 pandemic. Utilizing a unique hand-collected dataset comprising CSR disclosures from Vietnamese publicly listed firms in the VNR500 index between 2014 and 2021, the analysis employs both accounting-based (return on equity) and market-based (Tobin's Q) performance indicators. The empirical findings indicate a positive association between CSR disclosure and firm performance across both measures. Disaggregated analysis reveals that governance-related disclosures significantly enhance market valuation, whereas the presence of a …

The Effect Of A Kn95 Mask On High-Intensity Interval Training Performance, Physiological Response, And Perception, David Kenny, Payton Stanziani, Holly Chambers, Madison Vinovrski, Isabel Allocco, Jack Fisher, Morgan Raley, Kyle S. Beyer

International Journal of Exercise Science

International Journal of Exercise Science 18(3): 984-994, 2025. The purpose of this study was to assess the effect of a KN95 mask on the performance, physiological response, and perception of high-intensity interval training (HIIT). Twenty college-aged participants (Male: 10, Female: 10) completed a two-visit, crossover, counterbalanced study. The HIIT workout included four 1-minute “all-out” intervals at 3.5% of body mass with 4-minute rest intervals, performed with or without a KN95 mask. Following HIIT, participants remained on the cycle ergometer for a 15-minute recovery period. For each interval, peak power and average power were recorded. Throughout the HIIT workout and recovery, …

The Impact Of Public Relations Strategies On The Effectiveness Of Epidemic Management In Jordan: A Case Study Of Covid-19, Hazem Jamil Al-Rahahleh

Middle East Journal of Communication Studies

This study aimed to explore the impact of public relations strategies on the effectiveness of epidemic management in Jordan, using the COVID-19 pandemic as a case study. The study employed the descriptive-analytical method, which is based on the systematic description and interpretation of social and media phenomena. The findings revealed that public relations play a pivotal strategic role in managing health crises by building public trust, preparing communication plans, and formulating awareness messages in coordination with relevant authorities. The study recommended the need to enhance the training of public relations personnel in managing communication during health crises, to continue diversifying …

Finding Community: A Thematic Analysis Of Resilience During The Pandemic, Myles Kwitny, Quinn Richards, Grace Digirolamo, Shannon Freedman, Sophie Wenzel

Journal of Appalachian Health

Introduction: The Covid-19 pandemic impacted those within rural Appalachian communities, particularly people with marginalized identities.

Purpose: Through interviewing 44 participants from New River Valley, an Appalachian community in Virginia, this study sought to understand how resilience impacted individuals' experiences during the pandemic.

Methods: Participants belonged to one of the following groups: African American, Hispanic, older adults, or people who use drugs. Participants were required to reside in the New River Valley and be older than 18. Each participant was interviewed either in person, by phone, or over video call. Interviews were recorded, transcribed, then thematically analyzed for themes of resilience. …

Examining Proning Covid-19 Patients With Continuous Enteral Feedings: A Retrospective Study, Michael Legal, Sari Winham, Jennifer Ernst

International Nursing Research Congress (INRC)

The COVID-19 pandemic introduced a unique patient population requiring a triad of therapies: oxygen, nutrition, and patient positioning support. This study investigates the risk of aspiration pneumonia in COVID-19 patients placed in a prone position while receiving continuous enteral nutrition (EN). The retrospective, single-center study reviewed 97 electronic health records (EHR) of patients admitted between March 15, 2020, and June 1, 2022, at a southwest academic medical center. Patients included were diagnosed with COVID-19, aged 18 or older, and received continuous EN via nasogastric or nasoduodenal tubes while on high-flow oxygen support, excluding those on mechanical ventilation.

The study aimed …

Scenario Projections Of Covid-19 Burden In The Us, 2024-2025, Sara L Loo, Sung-Mok Jung, Lucie Contamin, Emily Howerton, Samantha J Bents, Harry Hochheiser, Michael C Runge, Claire P Smith, Erica C Carcelén, Katie Yan, Joseph C Lemaitre, Emily Przykucki, Clifton D Mckee, Koji Sato, Allison L Hill, Matteo Chinazzi, Jessica T Davis, Clara Bay, Alessandro Vespignani, Shi Chen, Rajib Paul, Daniel Janies, Jean-Claude Thill, Sean M Moore, T Alex Perkins, Ajitesh Srivastava, Majd Al Aawar, Kaiming Bi, Shraddha Ramdas Bandekar, Anass Bouchnita, Spencer J Fox, Lauren Ancel Meyers, Przemyslaw Porebski, Srinivasan Venkatramanan, Bryan Lewis, Jiangzhuo Chen, Madhav Marathe, Michal Ben-Nun, James Turtle, Pete Riley, Katriona Shea, Cécile Viboud, Justin Lessler, Shaun Truelove

Faculty, Staff and Student Publications

Importance: COVID-19 remains a disease with high burden in the US, prompting continued debate about optimal targets for annual vaccination.

Objective: To project COVID-19 burden in the US for April 2024 to April 2025 under 6 scenarios of immune escape (20% and 50% per year) and levels of vaccine recommendation (no recommendation, vaccination for individuals at high risk only, vaccination for all eligible groups) and to assess the potential benefit of vaccine recommendations in reducing disease burden.

Design, setting, and participants: For this decision analytical model, the US Scenario Modeling Hub, a collaborative modeling effort, convened 9 teams to provide …

Clinical Testing For Covid-19, Influenza, And Rsv In Hospitalized Youths, 2016-2024., Ariana P. Toepfer, Rachel E. Rutkowski, Leila C. Sahni, Geoffrey A. Weinberg, Marian G. Michaels, Rangaraj Selvarangan, Mary Allen Staat, Natasha Halasa, Janet A. Englund, Julie A. Boom, Peter G. Szilagyi, Jennifer E. Schuster, Elizabeth P P. Schlaudecker, Laura S. Stewart, Eileen J. Klein, Samantha M. Olson, Sascha Ellington, Meredith L. Mcmorrow, Heidi L. Moline, Fatimah S. Dawood, New Vaccine Surveillance Network Collaborators

Manuscripts, Articles, Book Chapters and Other Papers

IMPORTANCE: Studies of COVID-19, influenza, and respiratory syncytial virus (RSV) disease clinical epidemiology, disease burden, and vaccine effectiveness often rely on clinical testing to identify cases, particularly with increasing use of electronic health record data. However, few data are available describing clinical testing practices to inform interpretation of these studies.

OBJECTIVE: To characterize clinical testing frequency for SARS-CoV-2, influenza, and RSV among children and adolescents hospitalized with acute respiratory illness during the 2016 to 2024 respiratory illness seasons by age, intensive care unit admission, and time period (2016-2020 and each season in 2020-2024); estimate the case fraction missed by clinical …

Association Of Covid-19 Status With Maternal And Neonatal Outcomes Among Pregnant Women At Mombasa County Referral Hospital, Kenya, Salome Mghoi Rajab

MSc in Advanced Practice Midwifery

Background: COVID-19 pandemic has raised global concern regarding maternal and neonatal health owing to physiological and immunological changes that may heighten disease severity. Despite the global evidence linking COVID-19 infection with unfavorable pregnancy outcomes, data from Sub-Saharan Africa remain limited. This leaves an essential vacuum in our understanding of how COVID-19 status affects maternal and neonatal outcomes in counties like Mombasa, where health-care system problems may alter risks. Vertical transmission remains a puzzle to be solved.

Aim: To assess the association of COVID-19 status on maternal and neonatal outcomes between March 2020 to March 2022.

Methodology: A …

Differences In Physician Electronic Health Record Use By Telemedicine Intensity: Evidence From 2 Academic Medical Centers, Seunghwan Kim, Robert Thombley, Elise Eiden, Sunny Lou, Julia Adler-Milstein, Thomas Kannampallil, A Jay Holmgren

2020-Current year OA Pubs

OBJECTIVE: Evaluate the association between telemedicine intensity and ambulatory physician electronic health record (EHR) use following the COVID-19 pandemic.

MATERIALS AND METHODS: This retrospective study included ambulatory physicians in 11 specialties at 2 large academic medical centers (Washington University in St Louis [WashU], University of California San Francisco [UCSF]). EHR use measures, including time-based and frequency-based, were analyzed in the post-COVID-19 period (March 1, 2021, through March 7, 2022). Multivariable regression models with 2-way fixed effects were used to assess the association between telemedicine intensity and EHR use.

RESULTS: Fully telemedicine physician-weeks were associated with higher EHR (hours per 8 …

Restricted Social Engagement Is Associated With Depressive Symptoms In Older Chinese Adults: A Nationwide Cross-Sectional Study, Zheng Guo, Yulu Zheng, Yahong Zhu, Huacheng Wang, Jian Geng, Hengrui Liu, Piyong Ma, Lois Balmer, Xingang Li

Research outputs 2022 to 2026

Background and Aims: Social isolation has been linked to depressive symptoms in older adults. Previous studies have shown that greater engagement in social activities is associated with better mental health. However, it remains unclear whether restricted social engagement is related to poorer mental health outcomes. This study examined the association between reduced social activities/networking and the presence of depressive symptoms among community-dwelling older Chinese adults. Methods: During the COVID-19 pandemic, people chose to minimize going out to reduce the risk of infection, creating a natural setting that mimicked a passive intervention of restricted social engagement for community-based individuals. Data were …

Accordance And Conflict Between Religious And Scientific Precautions Against Covid-19 In 27 Societies, T. Samore, D.M.T. Fessler, A.M. Sparks, C. Holbrook, L. Aarøe, C.G. Baeza, M.T. Barbato, P. Barclay, R. Berniūnas, J. Contreras-Garduño, B. Costa-Neves, M.P. Grazioso, P. Elmas, P. Fedor, Li, Norman P., R. Fernández-Morales, L. Garcia-Marques, P. Giraldo-Perez, P. Gul, F. Habacht

Research Collection School of Social Sciences

Meaning-making systems underlie perceptions of the efficacy of threat-mitigating behaviors. Religion and science both offer threat mitigation, yet these meaning-making systems are often considered incompatible. Do such epistemological conflicts swamp the desire to employ diverse precautions against threats? Or do individuals—particularly individuals who are highly reactive to threats—hedge their bets by using multiple threat-mitigating practices despite their potential epistemological incompatibility? Complicating this question, perceptions of conflict between religion and science likely vary across cultures; likewise, pragmatic features of precautions prescribed by some religions make them incompatible with some scientifically-based precautions. The COVID-19 pandemic elicited diverse precautions thus providing an opportunity …

The Psychosocial Impact Of Covid-19 Mitigation Measures On Frontline Staff Providing Sexual Health And Family Planning Services In Kenya: A Mixed-Methods Study, Ferdinand Okwaro, Abdu Mohiddin, Marleen Temmerman

Centre of Excellence in Women and Child Health

Background The recognition of the unintended impact of COVID-19 mitigation measures to the availability of sexual and reproductive health (SRH) services led to the initiation of mitigation and health systems support mechanisms within public health facilities by the Ministry of Health (MoH) in Kenya to maintain pre-Covid-19 levels of SRH service provision. These recovery mechanisms however concentrated on policy and infrastructural elements of service provision with limited attention given to the psychosocial impacts of COVID-19 on health care workers (HCWs). This paper examines the psychosocial impact of COVID-19 on front line family planning (FP) and sexually transmitted infections (STI) management …

Utilization Of Outpatient Mental Health Services During And 2 Years After The Covid-19 Pandemic, Michelle A Hayek, Hye-Chung Kum, Sulki Park, Robert Ohsfeldt, Mark A Lawley, Michelle J Bovin

The Brown Foundation: Institute of Molecular Medicine

Objective: Analyze the impact of COVID-19 on outpatient mental health (OP-MH) utilization patterns, particularly telehealth, across eight different MH conditions with a 2-year follow-up.

Methods: This population-based cohort study uses a 5% random sample of Medicare beneficiaries aged ≥18 and newly diagnosed with one of the eight MH disorders: psychotic, depressive, bipolar, anxiety, trauma-related, substance-use, other MH disorders, and two or more MH disorders. Monthly OP-MH utilization patterns were compared among patients in 2020-2021 newly diagnosed in 2019 to comparable prepandemic cohorts newly diagnosed in 2017. Multiple logistic regression models were conducted to examine differences in telehealth utilization across MH …

Engaging Students And Stakeholders In Times Of Crisis: Hbcus Bridging Social Capital On Facebook While Navigating Physical Distancing, Pamela Peters

Journal of Research Initiatives

COVID-19 placed a strain on colleges that tend to rely on tuition, especially small HBCUs, which traditionally serve a high percentage of underrepresented students. Being away from campus, many stakeholders were experiencing higher levels of stress and anxiety. Social media offers an outlet for schools and stakeholders to stay connected during a crisis. Using social capital, this study examined how small HBCUs bridged social capital on Facebook during the year before and the first two years of the pandemic. A comparative analysis of Facebook posts of 30 HBCUs with a student population of under 2000 was conducted to determine post …

Covid-19 Adolescent Technology Use And Physical Activities: Cluster Analysis For Mental Health, Chunling Niu, Rui Jin, Ashley Love, Sohelia Sadeghi, Loren Cossette, Marissa Molina

Journal of Youth Development

This study examined how COVID-19 disrupted adolescent education, social interactions, and mental health by conducting exploratory cluster analysis to identify distinct profiles of technology use and physical activities, then comparing resulting clusters on demographics, social support, and mental health dimensions. Using the first wave of the longitudinal Oxford Achieving Resilience during COVID-19 (ARC) study of 1,196 United Kingdom adolescents aged 13-18, three clustering algorithms (k-means, k-medoids, and agglomerative hierarchical) identified optimal groupings validated both statistically and empirically. Three distinct clusters emerged: Cluster 1 (n = 380) characterized by low media use and moderate activity; Cluster 2 (n = 153) showing …

2d Speckle Tracking Strain Echocardiography In Multisystem Inflammatory Syndrome In Children: A Multicenter Analysis From The Music Study, Francesca Sperotto, Valiantsina Kazlova, Felicia L Trachtenberg, Dongngan T Truong, Sanjeev Aggarwal, Joseph R Block, Tamara T Bradford, Sujatha Buddhe, Audrey Dionne, Andreea Dragulescu, Kanwal M Farooqi, Daniel E Forsha, Therese M Giglia, Ian F Golding, Keren Hasbani, Pei-Ni Jone, Anita Krishnan, Sean M Lang, Carol A Mcfarland, Elizabeth C Mitchell, Elias Moussi Saad, Todd T Nowlen, Ricardo H Pignatelli, Scott Pletzer, Ryan Serrano, Divya Shakti, Shubhika Srivastava, Thor Thorsson, Jodie K Votava-Smith, Hunter C Wilson, Jane W Newburger, Kevin G Friedman

Faculty, Staff and Students Publications

Background: 2D-speckle tracking echocardiography may help detect subclinical ventricular dysfunction, but data in multisystem inflammatory syndrome in children (MIS-C) are scarce. We investigated left ventricular (LV) strain parameters in MIS-C and their association with outcomes.

Methods: We performed an ambi-directional, 32-center cohort study on hospitalized patients with MIS-C (March 2020-November 2021) with at least 1 echocardiogram read by the Core Lab. Generalized estimating equation modeling was used to test associations between LV strain and a composite in-hospital adverse cardiovascular outcome (vasoactive support, arrhythmias, cardiac arrest, extracorporeal support, death, or heart transplant).

Results: Of 349 patients (median age, 8.7 years [interquartile …

Cmr Findings In The Long-Term Outcomes After Multisystem Inflammatory Syndrome In Children (Music) Study, Sean M Lang, Dongngan T Truong, Andrew J Powell, Valiantsina Kazlova, Jane W Newburger, Jordan D Awerbach, Edem Binka, Tamara T Bradford, Mark Cartoski, Andrew Cheng, Michael P Dilorenzo, Audrey Dionne, Adam L Dorfman, Matthew D Elias, Olukayode Garuba, Jennifer F Gerardin, Keren Hasbani, Pei-Ni Jone, Christopher Z Lam, Nilanjana Misra, Lerraughn M Morgan, Arni Nutting, Jyoti K Patel, Joshua D Robinson, Eleanor L Schuchardt, Kristen Sexson Tejtel, Gautam K Singh, Timothy C Slesnick, Felicia Trachtenberg, Michael D Taylor, Music Study Investigators

Faculty, Staff and Students Publications

Background: Multisystem Inflammatory Syndrome in Children is characterized by high rates of acute cardiovascular involvement with rapid recovery of organ dysfunction. However, information regarding long-term sequelae is lacking. We sought to characterize the systolic function and myocardial tissue properties using cardiac magnetic resonance (CMR) imaging in a multicenter observational cohort of patients with Multisystem Inflammatory Syndrome in Children.

Methods: In this observational cohort study, comprising 32 centers in North America, CMR studies were analyzed by a core laboratory to assess ventricular volumetric data, tissue characterization, and coronary involvement.

Results: A total of 263 CMRs from 255 patients with Multisystem Inflammatory …