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Functional Analysis Of Conserved Motifs In The Mechanosensitive Channel Homolog Mscs-Like2 From Arabidopsis Thaliana, Gregory S. Jensen, Elizabeth S. Haswell Jan 2012

Functional Analysis Of Conserved Motifs In The Mechanosensitive Channel Homolog Mscs-Like2 From Arabidopsis Thaliana, Gregory S. Jensen, Elizabeth S. Haswell

Biology Faculty Research

The Mechanosensitive channel of Small conductance (MscS) of Escherichia coli has become an excellent model system for the structural, biophysical, and functional study of mechanosensitive ion channels. MscS, a complex channel with multiple states, contributes to protection against lysis upon osmotic downshock. MscS homologs are widely and abundantly dispersed among the bacterial and plant lineages, but are not found in animals. Investigation into the eukaryotic branch of the MscS family is in the beginning stages, and it remains unclear how much MscS homologs from eukaryotes resemble E. coli MscS with respect to structure, function, and regulation. Here we test the …

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Mind The Gap: A Comparative Study Of Migratory Behavior In Social Amoebae, Owen M. Gilbert, Jennie J. Kuzdzal-Fick, David C. Queller, Joan E. Strassmann Jan 2012

Mind The Gap: A Comparative Study Of Migratory Behavior In Social Amoebae, Owen M. Gilbert, Jennie J. Kuzdzal-Fick, David C. Queller, Joan E. Strassmann

Biology Faculty Research

Social amoebae aggregate to form a multicellular slug that migrates some distance. Most species produce a stalk during migration, but some do not. We show that Dictyostelium giganteum, a species that produces stalk during migration, is able to traverse small gaps and utilize bacterial resources following gap traversal by shedding live cells. In contrast, we found that Dictyostelium discoideum, a species that does not produce stalk during migration, can traverse gaps only when in the presence of other species’ stalks or other thin filaments. These findings suggest that production of stalk during migration allows traversal of gaps that commonly occurs …

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The Status Of Five State-Listed Tidal Plant Species In New Hampshire With Emphasis On Potential Impacts Of Sea Level Rise, Lauren A. Kras Jan 2012

The Status Of Five State-Listed Tidal Plant Species In New Hampshire With Emphasis On Potential Impacts Of Sea Level Rise, Lauren A. Kras

Master's Theses and Capstones

Tidal habitat in New Hampshire is restricted to 162 miles along coasts and estuaries. Limited area combined with anthropogenic impacts has caused 27 tidal plant species to be listed as threatened or endangered. In 2009 and 2010, the status of four threatened species: Eleocharis parvula, Samolus valerandi, Lilaeopsis chinensis , and Agalinis maritima and one endangered species Salicornia bigelovii was examined. To guide management and conservation, the historic and current distributions were compared and habitat features were determined. All five species were stable; however, S. valerandi and L. chinensis appear threatened by sea level rise and coastal squeeze as they …

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Structured Growth And Genetic Drift Raise Relatedness In The Social Amoeba Dictyostelium Discoideum, Neil J. Buttery, Chandra N. Jack, Boahemaa Adu-Oppong, Kate T. Snyder, Christoper R L Thompson, David C. Queller, Joan E. Strassmann Jan 2012

Structured Growth And Genetic Drift Raise Relatedness In The Social Amoeba Dictyostelium Discoideum, Neil J. Buttery, Chandra N. Jack, Boahemaa Adu-Oppong, Kate T. Snyder, Christoper R L Thompson, David C. Queller, Joan E. Strassmann

Biology Faculty Research

One condition for the evolution of altruism is genetic relatedness between altruist and beneficiary, often achieved through active kin recognition. Here, we investigate the power of a passive process resulting from genetic drift during population growth in the social amoeba Dictyostelium discoideum. We put labelled and unlabelled cells of the same clone in the centre of a plate, and allowed them to proliferate outward. Zones formed by genetic drift owing to the small population of actively growing cells at the colony edge. We also found that single cells could form zones of high relatedness. Relatedness increased at a significantly …

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The Effect Of Superman, Agamous, And Acs-7 Gene Manipulations On Sex Determination In Transgenic Fragaria Vesca 'Hawaii-4', Xin Ding Jan 2012

The Effect Of Superman, Agamous, And Acs-7 Gene Manipulations On Sex Determination In Transgenic Fragaria Vesca 'Hawaii-4', Xin Ding

Master's Theses and Capstones

Sex determination is of interest to plant breeders who transfer useful genes from wild relatives to the cultivated strawberry. The potential roles in sex determination of seven candidate genes, which included five SUPERMAN genes, the AGAMOUS gene, and the ACS-7 gene, were studied by re-introducing them into diploid strawberry as overexpression and RNAi constructs by Agrobacterium-mediated transformation. All of the transgenic calli expressed the GFP fluorescence marker. Among regenerated plants, some AGAMOUS-silenced plants transiently displayed a petalloid stamen or a vestigial petal phenotype, pointing to the AGAMOUS gene as negative regulator of A- and B-class genes according to the widely …

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A Qunanitative Evaluation Of Morphological Changes During Fusion Events In A Colony Of Didemnum Vexillum And Of Polycunum Constellatum, Andrea Frey Jan 2012

A Qunanitative Evaluation Of Morphological Changes During Fusion Events In A Colony Of Didemnum Vexillum And Of Polycunum Constellatum, Andrea Frey

Master's Theses and Capstones

We documented changes in the abundance and distribution patterns of cells involved in the allorecognition response in two species of colonial aplousobranch tunicates lacking a common vascular system. A histological examination of the fusion junction of isogeneic (CIAs) and allogeneic (CAAs) colony assays revealed that tunic cuticles were rapidly regenerated. The underlying tunic matrix fused readily in Didemnum vexillum in all assay and control types, however it did not fuse in CIAs in Polyclinum constellatum. We identified four and five different cell types in P. constellatum and D. vexillum, respectively. Phagocytic cells represented the most abundant cell type in both …

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Evolutionary Genomics And Ecoligical Interactions Of Biofilm Adaptation, Charles C. Traverse Jan 2012

Evolutionary Genomics And Ecoligical Interactions Of Biofilm Adaptation, Charles C. Traverse

Master's Theses and Capstones

How diversity evolves and persists in biofilms is essential for understanding much of microbial life, including the uncertain dynamics of chronic infections. We developed a novel biofilm model enabling long-term selection for daily adherence to and dispersal from a plastic bead in a test tube. Focusing on a pathogen of the cystic fibrosis (CF) lung, Burkholderia cenocepacia, we sequenced clones and metagenomes to unravel the mutations and evolutionary forces responsible for adaptation and diversification of a single biofilm community during 1050 generations of selection. The mutational patterns revealed recurrent evolution of biofilm specialists from generalist types and multiple adaptive alleles …

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Hemoglobin Type, Egg Buoyancy, And Antifreeze Glycoprotein Production As Mechanisms For Adaptive Variation In Gulf Of Maine Atlantic Cod (Gadus Morhua), Amanda R. Clapp Jan 2012

Hemoglobin Type, Egg Buoyancy, And Antifreeze Glycoprotein Production As Mechanisms For Adaptive Variation In Gulf Of Maine Atlantic Cod (Gadus Morhua), Amanda R. Clapp

Master's Theses and Capstones

Three physiological traits were examined to compare captive populations of winter- and spring-spawning cod from the Gulf of Maine, as differences in these traits have been observed in other locally-adapted subpopulations. Daily mean neutral buoyancy of hatchery-spawned eggs was observed at three temperatures (5, 10, and 12°C) and three photoperiods (15:9, 9:15, and 24:0 L: D) at 12°C. Body fluids of larvae held at 0°C for five days were tested for antifreeze glycoproteins (AFGPs) to determine the onset of AFGP production. Juveniles held at 0°C were bled between 20 and 35 days to determine induction time for AFGP production. Hemoglobin …

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Activity Rhythms Expressed By Juvenile American Horseshoe Crabs, Limulus Polyphemus, Elizabeth Anne Dubofsky Jan 2012

Activity Rhythms Expressed By Juvenile American Horseshoe Crabs, Limulus Polyphemus, Elizabeth Anne Dubofsky

Master's Theses and Capstones

The goals of this study were to determine if juvenile horseshoe crabs, Limulus polyphemus, express daily or tidal patterns of activity and how light and tidal cycles influence these patterns. When exposed to a light:dark cycle (n=24), 63% of juveniles exhibit daily patterns of locomotion and 25% of juveniles express circatidal patterns. When subsequently exposed to constant darkness, 17% express circadian rhythms of activity, 25% express a combination of circadian and circatidal patterns, and 46% express circatidal patterns of activity. When exposed to tidal cycles (n=42), 55% of juveniles express tidal patterns of activity, while the remainder exhibit either a …

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An Investigation Of Two Methods For Assessing The Vertical Structure Of Forest Stands, Daniel S. Maynard Jan 2012

An Investigation Of Two Methods For Assessing The Vertical Structure Of Forest Stands, Daniel S. Maynard

Master's Theses and Capstones

In this study we investigate the limitations of two methods for assessing forest structure: vertical point sampling with a camera and laser point quadrat sampling. Vertical point sampling with a camera is a method by which the height squared per unit area of a forest can be quickly estimated. First, we derive the bias incurred for failing to adjust for slope when implementing this sampling method, and we show that slope can generally be ignored as long as the majority of sample points occur on slopes less than 35 degrees. In the second part of this study we outline the …

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Effects Of Nitrogen Fertilization On Fungal Community Structure In A Temperate Hardwood Forest: Implicit Links Between Structure, Function And Resilience, Eric W. Morrison Jan 2012

Effects Of Nitrogen Fertilization On Fungal Community Structure In A Temperate Hardwood Forest: Implicit Links Between Structure, Function And Resilience, Eric W. Morrison

Master's Theses and Capstones

This study documents soil fungal communities at the Harvard Forest Chronic Nitrogen Addition experiment, which was established in 1989 to test the effects of long-term nitrogen fertilization on ecosystem processes. Researchers at this site have observed an accumulation of soil carbon in the nitrogen fertilized plots and a decrease in fungal biomass, ligninolytic enzyme activity, and rates of litter decay. We hypothesized that decreased decomposition rates in nitrogen-fertilized plots were due to changes in the structure of the fungal community, especially Basidiomycetes, the primary decomposers of lignin in this ecosystem. We performed a marker gene study of fungal communities in …

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Spatial And Temporal Variation In Degradation Of Dissolved Organic Carbon On The Main Stem Of The Lamprey River, Lucy Miller Parham Jan 2012

Spatial And Temporal Variation In Degradation Of Dissolved Organic Carbon On The Main Stem Of The Lamprey River, Lucy Miller Parham

Master's Theses and Capstones

Degradation of dissolved organic carbon by microbial and photolytic processes was examined along the main stem of the Lamprey River Watershed located in southeastern New Hampshire. Eight sites were chosen and sampled biweekly throughout the seasonal hydrograph. Lab incubations were employed to assess microbial degradation of dissolved organic carbon (DOC) where one set of samples was exposed to natural sunlight for a day to assess photolytic degradation. Mean biodegradable dissolved organic carbon (BDOC) throughout the study period was 5.8% with no significant variation observed between sites. Temporal variation was found to be a much stronger driver of DOC composition with …

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Lifelines Winter 2012, Southern Adventist University Jan 2012

Lifelines Winter 2012, Southern Adventist University

Lifelines - Biology Department Newsletter

The Winter 2012 issue of Lifelines contains articles on Southern's ancient DNA project, the Pre-dental club, and a pictorial directory of the 2012 biology and allied health graduates.

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Biology And Nursing Students’ Perceptions Of A Web-Based Information Literacy Tutorial, Sharon A. Weiner, Nancy Pelaez, Karen Chang, John M. Weiner Jan 2012

Biology And Nursing Students’ Perceptions Of A Web-Based Information Literacy Tutorial, Sharon A. Weiner, Nancy Pelaez, Karen Chang, John M. Weiner

Libraries Faculty and Staff Scholarship and Research

This study examined the perceptions of two groups of students to obtain different perspectives on the online information literacy tutorial, CORE (Comprehensive Online Research Education, to plan for its update. The CORE tutorial includes seven modules: “Planning Your Project,” “Topic Exploration,” “Types of Information,” “Search Tools,” “Search Strategies,” “Evaluating Sources,” and “Copyright, Plagiarism, and Citing Sources.” First-year students in biology and nursing courses responded to a survey after completing the CORE modules. Students indicated that they liked learning through an online tutorial. However, they thought that the tutorial could be improved with shorter modules and the addition of video and …

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Multi-Protein Detection Of Endothelial Cell Inflammation And Single Cells' Heterogeneity Study, Jingwen Chai Jan 2012

Multi-Protein Detection Of Endothelial Cell Inflammation And Single Cells' Heterogeneity Study, Jingwen Chai

Master's Theses and Capstones

Endothelial inflammation plays major roles in all phases of atherosclerotic process and both innate immunity and endothelial adhesion molecules contribute to endothelial inflammation. In this thesis, there are three main parts regarding the endothelial cell inflammation and multiple protein detection. In the first part, we applied multiple antibodies (Abs) to measure changes in expression levels of six proteins in response to inflammatory stimulation, and we observed different dynamic behaviors in them. In the second part, we applied emission fingerprinting technique provided by Zeiss LSM 510 META detector, and achieved the concurrent detection of ten proteins expressed on the same endothelial …

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Diversity And Dynamics Of Bacterial Communities In Early Life Stages Of The Caribbean Coral Porites Astreoides, Koty H. Sharp, Dan Distel, Valerie J. Paul Jan 2012

Diversity And Dynamics Of Bacterial Communities In Early Life Stages Of The Caribbean Coral Porites Astreoides, Koty H. Sharp, Dan Distel, Valerie J. Paul

Arts & Sciences Faculty Publications

In this study, we examine microbial communities of early developmental stages of the coral Porites astreoides by sequence analysis of cloned 16S rRNA genes, terminal restriction fragment length polymorphism (TRFLP), and fluorescence in situ hybridization (FISH) imaging. Bacteria are associated with the ectoderm layer in newly released planula larvae, in 4-day-old planulae, and on the newly forming mesenteries surrounding developing septa in juvenile polyps after settlement. Roseobacter clade-associated (RCA) bacteria and Marinobacter sp. are consistently detected in specimens of P. astreoides spanning three early developmental stages, two locations in the Caribbean and 3 years of collection. Multi-response permutation procedures analysis …

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Quantifying The Impacts Of Oyster Reef Restoration On Oyster Coverage, Wave Attenuation And Seagrass Fragment Retention In Mosquito Lagoon, Florida, Stephanie Garvis Jan 2012

Quantifying The Impacts Of Oyster Reef Restoration On Oyster Coverage, Wave Attenuation And Seagrass Fragment Retention In Mosquito Lagoon, Florida, Stephanie Garvis

Electronic Theses and Dissertations

The goal of this project was to determine the effects of oyster reef restoration on oyster coverage, wave height dissipation and seagrass recruitment. First, to assess the current versus historical coverage of natural, dead and restored oyster reefs within Mosquito Lagoon, aerial photographs from 2009, provided by Saint Johns River Water Management District, were digitized using ArcGIS software. Live reefs, restored reefs and dead reefs were screen digitized using a reef ‘signature’ in order to estimate the area of each type of reef. The 2009 maps were used as a guide to digitizing the historical aerial photographs (1943, 1951, 1967, …

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Race As A Legal Concept, Justin Deystone Jan 2012

Race As A Legal Concept, Justin Deystone

Publications

Race is a legal concept, and like all legal concepts, it is a matrix of rules. Although the legal conception of race has shifted over time, up from slavery and to the present, one element in the matrix has remained the same: the background rules of race have always taken a view of racial identity as a natural aspect of human biology. To be sure, characterizations of the rule have oftentimes kept pace with developments in race science, and the original invention of race as a rationale for the subordination of certain human populations is now a rationale with little …

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Prey And Plastic Ingestion Of Pacific Northern Fulmars (Fulmarus Glacialis) Collected In Monterey Bay, California, Erica Lynn Donnelly-Greenan Jan 2012

Prey And Plastic Ingestion Of Pacific Northern Fulmars (Fulmarus Glacialis) Collected In Monterey Bay, California, Erica Lynn Donnelly-Greenan

Master's Theses

Marine plastic pollution affects seabirds that mistake it for prey or incidentally ingest it with prey. Northern Fulmars (Fulmarus glacialis) and seabirds that feed at the water's surface ingest the most plastic. This can cause health issues, including satiety that possibly leads to inefficient foraging. The objectives of this study were to examine fulmar body condition, identify cephalopod diet and ingested plastic, predict foraging areas, and determine if prey number and size was correlated with ingested plastics in Pacific Northern Fulmars (Fulmarus glacialis rodgersii). Cephalopod prey were identified, measured, and enumerated; plastic and marine debris were categorized, enumerated, and weighed …

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Brown Treesnakes: A Potential Invasive Species For The United States, Samantha Sue Kahl, Scott E. Henke, Marc A. Hall, David K. Britton Jan 2012

Brown Treesnakes: A Potential Invasive Species For The United States, Samantha Sue Kahl, Scott E. Henke, Marc A. Hall, David K. Britton

Human–Wildlife Interactions

Brown treesnakes (ˆ) are mildly venomous, exotic snakes that have the potential to become an invasive species in North America, Hawaii, and the Commonwealth of the Northern Mariana Islands. The snake is native to northern and eastern Australia, New Guinea, and other islands of northern and western Melanesia. The snakes were first found outside their native range on Guam in 1953. The exact date they reached the island is uncertain, but they are believed to have arrived on military cargo transport vessels some time during or just after World War II. During the years that followed, the population of brown …

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Development Of A New Human Identity Testing Kit For The Simultaneous Amplification Of The 13 Codis Str Loci Plus Amelogenin Using Locus Specific Brackets (Lsbs), Lizmery Suarez Ferguson Jan 2012

Development Of A New Human Identity Testing Kit For The Simultaneous Amplification Of The 13 Codis Str Loci Plus Amelogenin Using Locus Specific Brackets (Lsbs), Lizmery Suarez Ferguson

Graduate Theses, Dissertations, and Problem Reports (ETD)

STR loci consist of short, repetitive sequence elements 2--7 base pairs in length. An STR genotype is typically determined by PCR amplification followed by fragment size estimation with electrophoresis. Commercial multiplex STR amplification kits are available for the 13 CORE loci used in the USA for human identity testing. The genotyping rationale with these multiplex STR amplification kits involves a two-fold calibration analysis: 1) An internal size standard (ISS) labeled with a separate dye establishes the size of the unknown DNA fragment and 2) an allelic ladder which contains most of the common alleles for each locus is also sized …

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From Bacteria To Human: Biophysical Studies Of Inward Rectifying Potassium Channels, Wayland Cheng Jan 2012

From Bacteria To Human: Biophysical Studies Of Inward Rectifying Potassium Channels, Wayland Cheng

All Theses and Dissertations (ETDs)

Inward rectifying potassium: Kir) channels are important in regulating cellular excitability in organs such as the heart, brain and pancreas. Prokaryotic KirBac channels are structurally similar to eukaryotic Kir channels, but distantly related and of unknown function. The goal of this thesis has been to investigate the functional properties of KirBac1.1 and to relate these findings to eukaryotic Kir channels. The approach was to use recombinantly-expressed, purified K+ channels--KirBac1.1, KcsA, Kir2.1 and Kir2.2--in order to integrate findings from functional studies, using liposomal flux assays and patch-clamping, with high-resolution crystal structures. By reconstituting KirBac1.1 into giant liposomes for patch-clamping, I show …

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Joint Functions Of Mett-10 And Dynein In The Caenorhabditis Elegans Germ Line, Maia Dorsett Jan 2012

Joint Functions Of Mett-10 And Dynein In The Caenorhabditis Elegans Germ Line, Maia Dorsett

All Theses and Dissertations (ETDs)

During normal development as well as in diseased states such as cancer, extracellular "niches" often provide cues to proximal cells and activate intracellular pathways. Activation of such signaling pathways in turn instructs cellular proliferation and differentiation. In the C.elegans gonad, GLP-1/Notch signaling instructs germ line stem cells to self renew through mitotic cell division. As germ cells progressively move out of the niche, they differentiate by entering meiosis and eventually form gametes. Using this model system, I uncovered a cooperative role for the METT-10 putative methyltransferase and the dynein motor complex in regulating the balance between germ cell proliferation and …

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The Role Of Autophagy And Il-17 In Bone Resorption, Carl Deselm Jan 2012

The Role Of Autophagy And Il-17 In Bone Resorption, Carl Deselm

All Theses and Dissertations (ETDs)

Osteoclasts are essential for skeletal homeostasis: Teitelbaum, 2000). These macrophage-lineage cells function by generating a polarized microenvironment between themselves and bone wherein skeletal matrix is degraded. This resorptive compartment is isolated from the general extracellular space by an actin ring which encompasses the ruffled border, a convoluted plasma membrane structure formed by its fusion with lysosome-related vesicles containing an electrogenic H+ATPase, a chloride channel, LAMP-1, and cathepsin K. In consequence, resorption of bone reflects secretion of HCl to mobilize mineral, and cathepsin K to degrade the collagen-rich organic matrix, into the resorptive space: Stenbeck, 2002; Zhao et al., 2008). We …

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Atm Deficiency -- A Multifaceted Defect In Lymphocyte Development, Beth Helmink Jan 2012

Atm Deficiency -- A Multifaceted Defect In Lymphocyte Development, Beth Helmink

All Theses and Dissertations (ETDs)

The generation of a functional antigen receptor gene in developing lymphocytes requires that the second exon be assembled through a process known as V(D)J recombination, a process that necessarily involves the generation and repair of DNA double-strand breaks made by the Rag endonuclease. Double strand breaks incurred during G1 of the cell cycle activate ATM, a PI3-kinase-like kinase that, in response to genotoxic DNA damage, is known to phosphorylate hundreds of proteins with unique and diverse functions. Notably, deficiencies in ATM lead to ataxia-telangiectasia, a syndrome characterized by lymphopenia, genomic instability and a predisposition to tumors involving antigen receptor loci …

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Morpholino Gene Knockdown In Adult Fundulus Heteroclitus: Role Of Sgk1 In Seawater Acclimation, Emily G. Notch, Joseph R. Shaw, Bonita A. Coutermarsh, Marisa Dzioba, Bruce A. Stanton Dec 2011

Morpholino Gene Knockdown In Adult Fundulus Heteroclitus: Role Of Sgk1 In Seawater Acclimation, Emily G. Notch, Joseph R. Shaw, Bonita A. Coutermarsh, Marisa Dzioba, Bruce A. Stanton

Dartmouth Scholarship

The Atlantic killifish (Fundulus heteroclitus) is an environmental sentinel organism used extensively for studies on environmental toxicants and salt (NaCl) homeostasis. Previous research in our laboratory has shown that rapid acclimation of killifish to seawater is mediated by trafficking of CFTR chloride channels from intracellular vesicles to the plasma membrane in the opercular membrane within the first hour in seawater, which enhances chloride secretion into seawater, thereby contributing to salt homeostasis. Acute transition to seawater is also marked by an increase in both mRNA and protein levels of serum glucocorticoid kinase 1 (SGK1) within 15 minutes of transfer. …

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Population Status, Habitat Dependence, And Reproductive Ecology Of Bahama Orioles: A Critically Endangered Synanthropic Species, Melissa R. Price, Valerie A. Lee, William K. Hayes Dec 2011

Population Status, Habitat Dependence, And Reproductive Ecology Of Bahama Orioles: A Critically Endangered Synanthropic Species, Melissa R. Price, Valerie A. Lee, William K. Hayes

Faculty Works

Recent elevation of critically endangered Bahama Orioles (Icterus northropi) to species status prompted us to evaluate their population status, habitat use, and breeding ecology. From surveys, we estimated that at least 141 to 254 individuals remain globally, with 90 to 162, 24 to 44, and 27 to 48 individuals remaining on North Andros Island, Mangrove Cay, and South Andros Island, The Bahamas, respectively. Orioles were observed nesting exclusively in anthropogenic habitat (residential and agricultural land), but home ranges also included nearby pine forest and coppice (dry broadleaf forest). Most nests (40 of 46, or 87%) were in nonnative coconut palm …

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Hands-On Labs (Hol): Using Technology And Web-Based Resources To Transform A Traditional Lab-Based Biology Course Into A Distance Learning (Dl) Hybrid Course, Across Schools At Pace University., Erica Kipp Dec 2011

Hands-On Labs (Hol): Using Technology And Web-Based Resources To Transform A Traditional Lab-Based Biology Course Into A Distance Learning (Dl) Hybrid Course, Across Schools At Pace University., Erica Kipp

Cornerstone 3 Reports : Interdisciplinary Informatics

No abstract provided.

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Heat Shock Protein, Hsp90 Plays A Role In Mt1-Mmp's Ability To Activate Substrate Proteins, Theresa Buck Dec 2011

Heat Shock Protein, Hsp90 Plays A Role In Mt1-Mmp's Ability To Activate Substrate Proteins, Theresa Buck

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

Membrane type 1 matrix metalloproteinase (MT1-MMP) plays a major role in cancer invasion and metastasis. The mechanism by which MT1-MMP is trafficked to the plasma membrane where it functions to proteolytically activate its substrate proteins is not fully understood. The gene of heat shock protein (Hsp90alpha) was identified as being upregulated in HT1080 cells treated with concanavalin A (conA), a lectin that promotes proMMP-2 activation and cell migration in HT1080 cells compared to untreated HT1080 cells. To determine the mechanism underlying MT1-MMP substrate degradation and cell migration, biological and biochemical approaches were carried out. Zymography was preformed to examine the …

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The Grizzly, December 1, 2011, Liz Kilmer, Nick Pane, Jacquelyn Heikel, Jenna Yaich, Lisa Jobe, Jordan Demcher, James Noebels, Julia Fox, Sara Sherr, Sarah Bollert, Satchel Summers, Julia Glauberman, Eilish Bennett, Rosemary Clark, Shane Eachus Dec 2011

The Grizzly, December 1, 2011, Liz Kilmer, Nick Pane, Jacquelyn Heikel, Jenna Yaich, Lisa Jobe, Jordan Demcher, James Noebels, Julia Fox, Sara Sherr, Sarah Bollert, Satchel Summers, Julia Glauberman, Eilish Bennett, Rosemary Clark, Shane Eachus

Ursinus College Grizzly Newspaper, 1978 to Present

Former Child Soldier Speaks for Peace • Landscaping Initiative Looks to Keep Campus Fresh • Fulbright Scholar to Join Ursinus This Spring • HIV Couple Speak on Sexual Health in Bomberger Auditorium • FFO Educates Students to Combat Bullying • Whitians' Woman to Watch: Stephanie Nocito, 2012 • Senior Interns with GlaxoSmithKline • UC United Aims to Help with Organization-run Events • Opinion: "Baby Bio" Insults Humanities Majors; Penn State Scandal Could Impact Victims of Sexual Assault; Students Desire an Off-Campus Shuttle Service; UC Provides Alternatives, Prepares for NBA Lockout • Post-Season Honors and Early Season Struggles

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