Digital Commons Network^™

Autophagy In Dna-Pkcs Knockout Glioblastoma Cancer Stem Cells, Samantha C. Diulus

Honors Capstones

Glioblastoma multiforme (GBM) is a deadly form of brain cancer, with an expected survival of only a few months after diagnosis without therapy. The current standard of care extends life expectancy by a couple of months due to almost universal recurrence of the tumor. Recurrence of GBM is highly dependent on a radiation-resistant subpopulation of GBM, the cancer stem cells (CSCs). CSCs possess an enhanced ability to repair therapy-induced DNA damage, especially DNA double strand breaks (DSBs). To study the role of DNA damage repair in GBM CSCs, our investigations used a knockout (KO) of an enzyme, DNA PKcs, which …

A Review Of The Global Commercial Cephalopod Fishery, With A Focus On Apparent Expansion, Changing Environments, And Management, Corey Clark

HCNSO Student Capstones

Cephalopods are both important predators and prey in many marine environments and important fishery resources in many countries. The global fishery has expanded almost continuously from landings of 580,000 metric tonnes in 1950 to over 4 m.t. in 2007. Cephalopods are ecological opportunists with highly plastic biological characteristics and varied population dynamics. Nearly all commercially harvested species are short-lived and can reproduce quickly, enabling them to evolve more rapidly under high selection pressure relative to many fish competitors and predators. As a result, they may have the biological means to be successful under conditions of long-term global climate change. This …

Bringing Science To Life In The Fifth-Grade Classroom Through Hands-On Learning, Kelly Gately

Honors Program Theses and Projects

Science helps provide insight into the unknown and provides an outlet for exploration of living things. Children are innately curious about how thing work, and they are eager to ask questions. Science is the perfect outlook for students to fully engage in their inquisitiveness, but yet, many classrooms are skipping over science lessons or choosing to heavily focus on other subjects, such as reading and writing. Science is often taught as an elective, integrated with other subjects or it is only focused on for a short period of time. Unfortunately, when this subject does receive attention, lessons are heavily text-book …

The Role Of Oxytocin On Social Behavior Associated With The Formation Of A Social Pair-Bond In The Socially Monogamous Convict Cichlid (Amatitlania Nigrofasciata), Christopher Garcia

Graduate Theses

The mechanisms for monogamy have evolved several times throughout history across various taxa in accordance with selective pressures. In vertebrates, monogamy is facilitated by the formation and the maintenance of social pair-bonds between mates. Social pair-bonds are a form of selective attachment that require complex neurobiological pathways in order to develop and continue. These neurobiological pathways are often regulated by neuroendocrine mechanisms, such as the release of the two neuroendocrine nonapeptides, oxytocin and arginine vasopressin, in specific parts of the brain or body. These neuroendocrine peptides play a big role in social and sexual behaviors. In prairie voles (Microtus ochrogaster) …

Gardner-Webb Honors Students Present Research At Regional Conference, Office Of University Communications

Gardner-Webb NewsCenter Archive

Honors students from Gardner-Webb University recently traveled to Memphis, Tenn., to participate in the Southern Regional Honors Council (SRHC) Conference. The 47th annual meeting was hosted by Northwestern Louisiana State University (Natchitoches). The SRHC promotes and advances honors programs and honors colleges in the Southern United States and has over 100 member institutions.

Bioinformatics Ii, Bio 3352, Course Outline, Eugenia G. Giannopoulou

Open Educational Resources

This course is a continuation of Bioinformatics I. Topics include gene expression, microarrays, next- generation sequencing methods, RNA-seq, large genomic projects, protein structure and stability, protein folding, and computational structure prediction of proteins; proteomics; and protein-nucleic acid interactions. The lab component includes R-based statistical data analysis on large datasets, introduction to big data analysis tools, protein visualization software, internet-based tools and high-level programming languages.

Pyy3-36 Efficacy Is Independent Of Photoperiod But Dependent On Time Of Day, Marissa Maroni

Honors Program Theses and Projects

Approximately 70% of Americans are overweight or obese and studies have shown that poverty-dense American counties are the most prone to obesity (Levine, 2011). Along with diet, the endogenous circadian rhythms have been found to be an important piece of human metabolic health. Circadian disruption in humans, such as jet-lag and shift work, have been linked to metabolic problems such as Type 2 Diabetes Mellitus and Metabolic Syndrome. Since circadian disruption affects many demographics including shift workers and routine business travelers it is imperative to understand the biological mechanism behind the relationship between circadian disruption and weight gain. One potential …

Advanced Cell & Molecular Biology Ii Cmb 502, Michael Cerbo

Library Impact Statements

No abstract provided.

Enhancing The Anti-Tumor Efficacy Of T Cells With Naturally Occurring Plant Stilbenes, Elle Richardson, Andrea Leigh Soles

Undergraduate Publications

Despite advances in treatment options, cancer remains the second leading cause of death in the United States. Many therapies use immune cells, specifically T cells, for cancer therapy. To enhance tumor recognition by T cells, chimeric antigen receptors consisting of signaling domains fused to receptors that recognize tumor antigens can be created and expressed in T cells. One receptor that is a prospective target for a chimeric antigen receptor is PD1 because the ligands for the PD1 receptor are expressed on many cancer types. Our lab has genetically engineered a chimeric PD1 (chPD1) receptor and has shown that chPD1-expressing T …

Advanced Cell And Molecular Biology I Cmb 501, Michael Cerbo

Library Impact Statements

No abstract provided.

04-15-2019 Swosu Biology Students And Chapter Win Awards At Tri Beta, Southwestern Oklahoma State University

THE BARK ARCHIVE 2019

Eleven Southwestern Oklahoma State University biology students recently presented their research findings at the Beta Beta Beta (National Biology Honor Society) South Central Region Convention held in Cedar Hill (TX).

The Vast Wonder Of The World: Biologist Ernest Everett Just, Maryn Wheeler

Children's Book and Media Review

No abstract provided.

Laboratory Rotations In Cell And Molecular Biology, Michael Cerbo

Library Impact Statements

No abstract provided.

How Do Bacteria Handle Microgravity?, Shea Stewart

University of Mississippi News

UM professor's research investigates controlling microorganisms in space

Consistency Is Futile!: Selecting Phycoremediators For Consortia, Tori Spencer

BIO 410 Spring 2019 Research Papers

Bioremediation is the process by which organisms remove and transform toxic compounds in a contaminated source. This is a waste management technique currently used to clean up man-made contamination. Many organisms act as natural remediators; in the case of algae, they are called phycoremediators who perform phycoremediaton. The term algae encompasses a variety of taxonomic groups and their diversity is still being realized; there are over 44,000 named species of the 72,000 species that we have identified. Some estimates calculate that there are over 200,000 diatom species alone. This diversity continues to be difficult to organize, which is problematic for …

Investigating The Effects Of Cancer Mutations On The Activity Of P300, Meghan Hall

Spring Showcase for Research and Creative Inquiry

Investigating the effects of cancer mutations on the activity of p300

An Evaluation Of Elemental Composition Of Soils Associated With Ground Nesting Ants In The Family Formicidae In Somerset County, Maine, Haley H. Depner

All Student Scholarship

Ants are keystone organisms and engineers in many ecosystems, playing an important role in nutrient cycling and rearrangement of organic and inorganic materials through foraging, waste management and, in subterranean species, nest construction and maintenance. In this study, I conducted elemental analysis of soils for calcium, copper, iron, potassium, manganese and zinc in and around the colonies of subterranean nesting ants. The two-step analysis used in this study utilizes the efficiency of X-Ray Fluorescence (XRF) Spectrometry to look for overall trends in elemental composition followed by Flame Atomic Absorbance (AA) to achieve higher resolution of select elements of interest as …

Gwu Research Prepares Student For Career As Clinical Researcher And Practitioner, Office Of University Communications

Gardner-Webb NewsCenter Archive

Born with a weak immune system and no pituitary gland, Damian Chance Hutchins ’19 spent much of his early life in the hospital. The experience gave the Gardner-Webb University senior an appreciation for caring practitioners and a desire to help others. Hutchins, of Cherryville, N.C., is majoring in biology with a concentration in biomedical sciences, and his goal is to become a physician assistant and clinical researcher.

Ability Of Flavonoids To Mimic The Estrogen Receptor To Drive Myeloid Derived Suppressor Cell Differentiation, Megan Bland, Cecilie Elliott, Kathryn Kosiorek

Spring Showcase for Research and Creative Inquiry

Flavonoids are natural compounds found in dietary elements such as soy, grains, and vegetables that have the potential to bind to the estrogen receptor. Activation of the estrogen receptor drives myeloid derived suppressor cell (MDSC) accumulation, cells that increase during cancer, inflammation, and infection. In this study, we are investigating specific flavonoids, such as epigallocatechin-3-gallate (EGCG), kaempferol, naringenin, daidzein, and genistein, for their ability to mimic estrogen. After examination, we expect that MDSC differentiation will decrease upon treatment of the chosen flavonoids, leading to reduced carcinogenic effects.

The Use Hela Derived Telomerase On Nk Cells In The Treatment Of Ovarian Cancer, Juwairyah Gunter

Spring Showcase for Research and Creative Inquiry

A research proposal for a novel immunotherapy for treating ovarian cancer.

Study Guides And Videos For Openstax Biology, Chapters 5-7 (Egsc), Martiana Sega, David Chevalier

Biological Sciences Ancillary Materials

This set of videos and study guides for OpenStax Biology was created under an ALG Mini-Grant for Ancillary Materials Creation and Revision. Two videos on energy coupling and osmosis are included, along with study guides for chapters 5-8:

• Plasma Membrane
• Metabolism
• Cellular Respiration

All files are included in one .zip folder.

Manipulating Light: Creating A Biomimetic Photonic Crystal Material Inspired By The Chameleon, Love L. Richburg

Honors Theses

The purpose of this project is to create a chameleon-inspired biomimetic material using guanine crystals and polydimethylsiloxane (PDMS) to form a tunable photonic crystal and then characterize the material. The method for developing this material is to first synthesize a photonic crystal made of a guanine microsphere lattice. Then embed the guanine lattice in PDMS. Since PDMS is an elastomer, it can be stretched to adjust the spacing between the guanine crystals. This should allow for the photonic crystal to be adjusted similarly to the way that the chameleon adjusts the photonic crystal in its skin by changing the spacing …

Zero Textbook Cost Syllabus For Env 3009/4900 (Conservation Biology And Sustainable Development), Stephen Gosnell

Open Educational Resources

Conservation biology is an interdisciplinary topic that explores how we can protect and maintain natural areas. Due to the resources we take and impacts we have on natural environments, this field is directly related to restoration ecology (restoring natural areas) and sustainable development/natural resource management. We will explore the basis for these related fields from an ecological, social, legal, and cultural perspective, as all conservation and management projects take place in the larger human landscape. We will consider how we measure biodiversity, why it matters, why is it is threatened, and how we can manage (protect, restore, maintain, use) it …

Effective Use Of Self-Education And E-Educational Resources While Raising Competence Of Biology Teachers, X.K Karshibaev, D Togaeva

Bulletin of Gulistan State University

The article discusses the use of self-education elements and creation of e-resources while raising competence of secondary schools teachers of biology.

High Expression Of Osm And Il-6 Are Associated With Decreased Breast Cancer Survival: Synergistic Induction Of Il-6 Secretion By Osm And Il-1Β, Ken Tawara, Hannah Scott, Jacqueline Emathinger, Cody Wolf, Dollie Lajoie, Danielle Hedeen, Laura Bond, Cheryl Jorcyk

Biomedical Research Institute Publications and Presentations

Chronic inflammation has been recognized as a risk factor for the development and maintenance of malignant disease. Cytokines such as interleukin-6 (IL-6), oncostatin M (OSM), and interleukin-1 beta (IL-1β) promote the development of both acute and chronic inflammation while promoting in vitro metrics of breast cancer metastasis. However, anti-IL-6 and anti-IL-1β therapeutics have not yielded significant results against solid tumors in clinical trials. Here we show that these three cytokines are interrelated in expression. Using the Curtis TCGA™ dataset, we have determined that there is a correlation between expression levels of OSM, IL-6, and IL-1β and reduced breast cancer patient …

H/L Ratio As A Measurement Of Immune Function In Terrapene Ornata Species, Vesa Govori

Honors Program: Senior Projects (Public)

White blood cells are a key part of the immune system, and changes in white cell count can reveal the overall state of health and the immune systems functional ability of a species. White blood such as heterophils and lymphocytes are essential for being able to fight off infections. Analyzing different cell ratios has been commonly done before as a way to observe immune function in bird species as well as other species. Understanding that there are different functions between the different white blood cells provides an extra interesting perspective to what could be happening in the immune system function …

03-06-2019 Swosu Biology Student Named Young Ambassador For American Society Of Microbiology, Southwestern Oklahoma State University

THE BARK ARCHIVE 2019

Southwestern Oklahoma State University biology student Jennifer Abshire of McLoud was recently named the American Society of Microbiology (ASM) Young Ambassador for the state of Oklahoma.

Using Motion-Activated Trail Cameras To Study Diet And Productivity Of Cliff-Nesting Golden Eagles, Jordan T. Harrison, Michael N. Kochert, Benjamin P. Pauli, Julie A. Heath

Raptor Research Center Publications and Presentations

Studies of cliff-nesting raptors can be challenging because direct observations of nest contents are difficult. Our goals were to develop a protocol for installing motion-activated trail cameras at Golden Eagle (Aquila chrysaetos) nests to record diet information and productivity, and to estimate prey detection probability using different diet study methods. In 2014 and 2015, we installed cameras at 12 Golden Eagle nests with 18–42-d-old nestlings. Following installation, we monitored adult behavior using direct observation and post-installation image review. At two nests, adult eagles did not return to nests or exhibited behaviors suggesting avoidance of the cameras, but returned …

Gwu Chemistry And Ecology Professors Inspired Alumnus To Study Wildlife Conservation, Office Of University Communications

Gardner-Webb NewsCenter Archive

Two years before Michael Byron, of San Antonio, Texas, was recruited to the men’s basketball program at Gardner-Webb University, he watched the GWU team defeat the Kentucky Wildcats, 84-68, in a televised game. The historic win was on his mind when he decided to visit the GWU campus. “I got along really well with the players and the coaches,” Byron reflected.

Student Perceptions Of Reasons For Lecture And Active Learning, Calan Koch

Honors Program: Senior Projects (Public)

With perceived student resistance to active learning in the classroom, instructors are hesitant to implement such methods into their classroom structure despite how effective they may be. This research seeks to understand student perceptions related to the transition to higher prevalence of active learning techniques. We aimed to find answers to how students perceive the ideal classroom to be structured, what reasons they perceive for lecture and active learning components, and possible explanations to concerns of groupwork during class time. We analyzed 64 interviews with undergraduate biology students at the University of Nebraska- Lincoln, developed coding rubrics from commonly found …